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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Molecular Imaging and Contrast Agent Database (MICAD) [Internet]" /><meta name="citation_title" content="111In-Capromab pendetide" /><meta name="citation_publisher" content="National Center for Biotechnology Information (US)" /><meta name="citation_date" content="2008/05/24" /><meta name="citation_author" content="Kam Leung" /><meta name="citation_pmid" content="20641439" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK23237/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="111In-Capromab pendetide" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Center for Biotechnology Information (US)" /><meta name="DC.Contributor" content="Kam Leung" /><meta name="DC.Date" content="2008/05/24" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK23237/" /><meta name="description" content="Prostate-specific membrane antigen (PSMA) is a unique type II, transmembrane-bound glycoprotein that is overexpressed on prostate tumor cells and in the neovasculature of most of the solid tumors, but not in the vasculature of normal tissues (1, 2). 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK23237_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK23237_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/Z1907-BZ-DPTA111In/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/Mindin19G9-111In/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK23237_"><span class="title" itemprop="name"><sup>111</sup>In-Capromab pendetide </span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"><sup>111</sup>In-CYT-356</div><p class="contrib-group"><span itemprop="author">Kam Leung</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK23237_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK23237_ai__"><div class="contrib half_rhythm"><span itemprop="author">Kam Leung</span>, PhD<div class="affiliation small">
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National Center for Biotechnology Information, NLM, NIH, Bethesda, MD,
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<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a>
|
||
</div></div></div><p class="small">Created: <span itemprop="datePublished">October 5, 2005</span>; Last Update: <span itemprop="dateModified">May 24, 2008</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="Capromab111In.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK23237/table/Capromab111In.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Capromab111In.T1_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-Capromab pendetide</td><td rowspan="9" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-CYT-356, <sup>111</sup>In-GYK-DTPA-7E11-C5.3, <sup>111</sup>In-DTPA-7E11-C5.3, <sup>111</sup>In-7E11-C5.3</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ProstaScint®</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antibody</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
|
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Prostate-specific membrane antigen (PSMA)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target Category:</b>
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||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antibody-antigen binding</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
|
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SPECT</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
||
<b>Source of signal:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
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<b>Activation:</b>
|
||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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||
</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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||
|
||
</div></li></ul>
|
||
<ul class="simple-list"><li class="half_rhythm"><div>
|
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
|
||
</div></li></ul>
|
||
<ul class="simple-list"><li class="half_rhythm"><div>
|
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Humans
|
||
</div></li></ul>
|
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Click on <a href="/entrez/viewer.fcgi?db=protein&val=4758398" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a>, <a href="/entrez/viewer.fcgi?db=nucleotide&val=4758397" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> (RefSeq), and <a href="/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=2346" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gene</a> for more information about PSMA.</td></tr></tbody></table></div></div><div id="Capromab111In.Background"><h2 id="_Capromab111In_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28Capromab%20Pendetide%20or%20cyt-356%20or%207e11%29%20and%20Indium" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Prostate-specific membrane antigen (PSMA) is a unique type II, transmembrane-bound glycoprotein that is overexpressed on prostate tumor cells and in the neovasculature of most of the solid tumors, but not in the vasculature of normal tissues (<a class="bk_pop" href="#Capromab111In.REF.1">1</a>, <a class="bk_pop" href="#Capromab111In.REF.2">2</a>). This unique expression of PSMA makes it an important biomarker as well as a large extracellular target of imaging agents (<a class="bk_pop" href="#Capromab111In.REF.3">3</a>, <a class="bk_pop" href="#Capromab111In.REF.4">4</a>). 7E11-C5, a monoclonal antibody against the cytoplasmic domain of PSMA, was found to be specific to prostate tumor tissues in humans when conjugated with glycyl-tyrosyl-(<i>N</i>-ε-diethylenetriamine pentacetic acid)-lysine (GYK-DTPA). Tumors often contain dying or necrotic cells with permeable membranes, allowing the binding of antibodies to the intracellular epitope of PSMA. The antibody conjugate (Capromab pendetide or CYT-365) was radiolabeled with <sup>111</sup>Indium. <sup>111</sup>In-CYT-356 was approved by the US Food and Drug Administration in 1996 for the detection of prostate carcinoma and soft tissue metastases in prostate cancer patients. Newer antibodies against the extracellular domain of PSMA are being developed for immunotherapy of prostate cancer (<a class="bk_pop" href="#Capromab111In.REF.5">5</a>, <a class="bk_pop" href="#Capromab111In.REF.6">6</a>).</p></div><div id="Capromab111In.Synthesis"><h2 id="_Capromab111In_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28Capromab%20Pendetide%20or%20cyt-356%20or%207e11%29%20and%20Indium%20and%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Purified monoclonal antibody 7E11-C5.3 was coupled with GYK-DTPA by site-specifically generated reactive aldehyde groups on the oligosaccharides found on the heavy chain of the antibody (<a class="bk_pop" href="#Capromab111In.REF.7">7</a>). A mixture of <sup>111</sup>InCl<sub>3</sub> (37 MBq, 1 mCi) and the conjugated antibody (100 μg) was incubated for 1 h at 37ºC. <sup>111</sup>In-CYT-356 was purified by high performance chromatography (<a class="bk_pop" href="#Capromab111In.REF.8">8</a>). The specific activity was 55.5-210.9 MBq/mg (1.5-5.7 mCi/mg).</p><p><sup>111</sup>In-CYT-356 can be easily prepared from a commercially available kit consisting of two vials to be mixed: 1) a sterile solution of 185 MBq/ml (5 mCi/ml) <sup>111</sup>In-choride in sodium acetate buffer; and 2) a sterile solution of 0.5 mg of CYT-356. The mixture was incubated at room temperature for 30 min and filtered through a 0.22-μm filter.</p></div><div id="Capromab111In.In_Vitro_Studies_Tes"><h2 id="_Capromab111In_In_Vitro_Studies_Tes_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28Capromab%20Pendetide%20or%20cyt-356%20or%207e11%29%20and%20Indium%20and%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>LNCaP human prostate cancer cells were reported to have a <i>K</i><sub>d</sub> of 6.69 n<span class="small-caps">m</span> with [<sup>131</sup>I]7E11-C5 and <i>B</i><sub>max</sub> of 95,000 sites/cell in saturation binding studies (<a class="bk_pop" href="#Capromab111In.REF.9">9</a>) using intact cells. The binding was accounted for by a subpopulation of permeated cells produced when the cells were trypsinized and washed. Little internalization of the tracer was found over a period of 48 h at 37ºC. When permeated cells were used, the number of binding sites/cell was similar to [<sup>131</sup>I]J591, an antibody against the extracellular domain of PSMA. Using nonpermeated cells, [<sup>131</sup>I]J591 has a <i>K</i><sub>d</sub> of 1.83 n<span class="small-caps">m</span> and a <i>B</i><sub>max</sub> of 600,000-800,000 sites/cell.</p><p>Various immunohistochemical studies indicate that 7E11-C5 reacts weakly with normal prostate epithelial cells and strongly with malignant prostate epithelial cells but does not react with non-prostate tumors or most normal tissues (<a class="bk_pop" href="#Capromab111In.REF.8">8</a>, <a class="bk_pop" href="#Capromab111In.REF.10">10-14</a>). It also stains endothelial cells in solid tumors, such as lung, renal, colon, and breast carcinomas but not in normal vascular endothelial cells (<a class="bk_pop" href="#Capromab111In.REF.15">15</a>, <a class="bk_pop" href="#Capromab111In.REF.16">16</a>).</p></div><div id="Capromab111In.Animal_Studies"><h2 id="_Capromab111In_Animal_Studies_">Animal Studies</h2><div id="Capromab111In.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28Capromab%20Pendetide%20or%20cyt-356%20or%207e11%29%20and%20Indium%20and%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Biodistribution of <sup>111</sup>In-CYT-356 was studied in LNCaP tumor-bearing nude mice by <i>ex vivo</i> tissue radioactivity measurements (<a class="bk_pop" href="#Capromab111In.REF.8">8</a>). <sup>111</sup>In-CYT-356 uptake in tumor was high with 14% injected dose/g (ID/g) on day 1 after injection of 11.7 μg of the tracer (0.59 MBq, 16 μCi). It increased to 30% ID/g on days 3 and 7. Tumor image was visible by scintigraphic scan on day 4. Uptake in the lung, spleen, liver, and kidney was 4-6% ID/g, whereas the muscle showed an uptake of <1% ID/g. Uptake in non-tumor organs was similar in tumor-bearing mice and normal mice. <sup>111</sup>In-CYT-356 did not accumulate in PC-3 and Du-145 prostate tumor lines (PSMA negative). Furthermore, <sup>111</sup>In-labeled GYK-DTPA-conjugated, nonspecific antibody did not localize to the LNCaP tumor.</p></div><div id="Capromab111In.Other_NonPrimate_Mam"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28Capromab%20Pendetide%20or%20cyt-356%20or%207e11%29%20and%20Indium%20and%20%28dog%20or%20pig%20or%20rabbit%20or%20sheep%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="Capromab111In.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28Capromab%20Pendetide%20or%20cyt-356%20or%207e11%29%20and%20Indium%20and%20%28primate%20not%20human%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="Capromab111In.Human_Studies"><h2 id="_Capromab111In_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28Capromab%20Pendetide%20or%20cyt-356%20or%207e11%29%20and%20Indium%20and%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Human dosimetry of <sup>111</sup>In-CYT-356 was estimated in 25 prostate cancer patients (<a class="bk_pop" href="#Capromab111In.REF.17">17</a>). Dynamic whole-body positron emission tomography (PET) scans were acquired after the injection of 185 MBq (5 mCi) of <sup>111</sup>In-CYT-356 over a 7-10-day period. The organ that received the highest absorbed dose was the liver (1.0 mGy/MBq or 3.7 rad/mCi), followed by the spleen (0.88 mGy/MBq or 3.3 rad/mCi), and the kidneys (0.67 mGy/MBq or 2.5 rad/mCi). The prostate was estimated at 0.44 mGy/MBq (1.63 rad/mCi). The effective dose was calculated as 0.25-0.29 mSv/MBq (0.93-1.07 rem/mCi).</p><p>In one of the pivotal studies, <sup>111</sup>In-CYT-356 scans (152 patients with prostate cancer) had a sensitivity, specificity, and overall accuracy of 62, 72, and 68%, respectively (<a class="bk_pop" href="#Capromab111In.REF.18">18</a>). The sensitivity of computed tomography (CT) and magnetic resonance imaging (MRI) was 4% and 15%, respectively.</p><p>Sodee et al. (<a class="bk_pop" href="#Capromab111In.REF.19">19</a>) reported the results of a retrospective study of 2,290 <sup>111</sup>In-CYT-356 scans of 2,154 patients with prostate cancer performed at 15 institutions. <sup>111</sup>In-CYT-356 scans identified positive uptake in the prostate or fossa (70.4%), pelvic nodes (31.5%), pelvic and extrapelvic nodes (23.9%), and extrapelvic nodes only (11.0%). In patients with newly diagnosed prostate cancer (<i>n</i> = 487), there was a significant correlation (<i>p</i> < 0.001) of prostate-specific antigen (PSA) level with positive <sup>111</sup>In-CYT-356 scans in the prostate bed and pelvic metastases. The association between PSA level and positive <sup>111</sup>In-CYT-356 scans in the fossa recurrence was weaker (<i>p</i> < 0.033) in patients after surgery (<i>n</i> = 1,225) and was not significant for pelvic and extrapelvic metastases. There was no association between PSA level and <sup>111</sup>In-CYT-356 scans in patients with radiation therapy (<i>n</i> = 340) or hormonal therapy (<i>n</i> = 238).</p><p><sup>111</sup>In-CYT-356 imaging has been studied in the detection of nodal metastases, detection of recurrent prostate cancer, detection of occult extraprostatic fossa, and evaluation before definitive therapy in patients with prostate cancer [<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28Capromab%20Pendetide%20or%20cyt-356%20or%207e11%29%20and%20Indium%20and%20human%20and%20review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]. Fusion studies of <sup>111</sup>In-CYT-356 scans with CT or MRI improve the prediction of lymph node metastases in patients for definitive local therapy (<a class="bk_pop" href="#Capromab111In.REF.20">20</a>, <a class="bk_pop" href="#Capromab111In.REF.21">21</a>).</p></div><div id="Capromab111In.references"><h2 id="_Capromab111In_references_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="Capromab111In.REF.1">Feneley M.R. , Jan H. , Granowska M. , Mather S.J. , Ellison D. , Glass J. , Coptcoat M. , Kirby R.S. , Ogden C. , Oliver R.T. , Badenoch D.F. , Chinegwundoh F.I. , Nargund V.H. , Paris A.M. , Britton K.E. Imaging with prostate-specific membrane antigen (PSMA) in prostate cancer. <span><span class="ref-journal">Prostate Cancer Prostatic Dis. </span>2000;<span class="ref-vol">
|
||
<strong>3</strong>
|
||
</span>(1):47–52.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12497162" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12497162</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="Capromab111In.REF.2">Ghosh A. , Heston W.D. Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. <span><span class="ref-journal">J Cell Biochem. </span>2004;<span class="ref-vol">
|
||
<strong>91</strong>
|
||
</span>(3):528–39.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14755683" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14755683</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="Capromab111In.REF.3">Nanus D.M. , Milowsky M.I. , Kostakoglu L. , Smith-Jones P.M. , Vallabahajosula S. , Goldsmith S.J. , Bander N.H. Clinical use of monoclonal antibody HuJ591 therapy: targeting prostate specific membrane antigen. <span><span class="ref-journal">J Urol. </span>2003;<span class="ref-vol">
|
||
<strong>170</strong>
|
||
</span>(6 Pt 2):S84–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14610416" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14610416</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="Capromab111In.REF.4">Nargund V. , Al Hashmi D. , Kumar P. , Gordon S. , Otitie U. , Ellison D. , Carroll M. , Baithun S. , Britton K.E. Imaging with radiolabelled monoclonal antibody (MUJ591) to prostate-specific membrane antigen in staging of clinically localized prostatic carcinoma: comparison with clinical, surgical and histological staging. <span><span class="ref-journal">BJU Int. </span>2005;<span class="ref-vol">
|
||
<strong>95</strong>
|
||
</span>(9):1232–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15892807" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15892807</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="Capromab111In.REF.5">Bander N.H. , Trabulsi E.J. , Kostakoglu L. , Yao D. , Vallabhajosula S. , Smith-Jones P. , Joyce M.A. , Milowsky M. , Nanus D.M. , Goldsmith S.J. Targeting metastatic prostate cancer with radiolabeled monoclonal antibody J591 to the extracellular domain of prostate specific membrane antigen. <span><span class="ref-journal">J Urol. </span>2003;<span class="ref-vol">
|
||
<strong>170</strong>
|
||
</span>(5):1717–21.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14532761" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14532761</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="Capromab111In.REF.6">Smith-Jones P.M. , Vallabhajosula S. , Navarro V. , Bastidas D. , Goldsmith S.J. , Bander N.H. Radiolabeled monoclonal antibodies specific to the extracellular domain of prostate-specific membrane antigen: preclinical studies in nude mice bearing LNCaP human prostate tumor. <span><span class="ref-journal">J Nucl Med. </span>2003;<span class="ref-vol">
|
||
<strong>44</strong>
|
||
</span>(4):610–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12679407" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12679407</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="Capromab111In.REF.7">Rodwell J.D. , Alvarez V.L. , Lee C. , Lopes A.D. , Goers J.W. , King H.D. , Powsner H.J. , McKearn T.J. Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations. <span><span class="ref-journal">Proc Natl Acad Sci U S A. </span>1986;<span class="ref-vol">
|
||
<strong>83</strong>
|
||
</span>(8):2632–6.</span> [<a href="/pmc/articles/PMC323353/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC323353</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/3458222" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3458222</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="Capromab111In.REF.8">Lopes A.D. , Davis W.L. , Rosenstraus M.J. , Uveges A.J. , Gilman S.C. Immunohistochemical and pharmacokinetic characterization of the site-specific immunoconjugate CYT-356 derived from antiprostate monoclonal antibody 7E11-C5. <span><span class="ref-journal">Cancer Res. </span>1990;<span class="ref-vol">
|
||
<strong>50</strong>
|
||
</span>(19):6423–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/1698122" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1698122</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="Capromab111In.REF.9">Smith-Jones P.M. , Vallabahajosula S. , Goldsmith S.J. , Navarro V. , Hunter C.J. , Bastidas D. , Bander N.H. In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen. <span><span class="ref-journal">Cancer Res. </span>2000;<span class="ref-vol">
|
||
<strong>60</strong>
|
||
</span>(18):5237–43.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11016653" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11016653</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="Capromab111In.REF.10">Horoszewicz J.S. , Kawinski E. , Murphy G.P. Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients. <span><span class="ref-journal">Anticancer Res. </span>1987;<span class="ref-vol">
|
||
<strong>7</strong>
|
||
</span>(5B):927–35.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2449118" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2449118</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="Capromab111In.REF.11">Murphy G.P. , Elgamal A.A. , Troychak M.J. , Kenny G.M. Follow-up ProstaScint scans verify detection of occult soft-tissue recurrence after failure of primary prostate cancer therapy. <span><span class="ref-journal">Prostate. </span>2000;<span class="ref-vol">
|
||
<strong>42</strong>
|
||
</span>(4):315–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10679761" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10679761</span></a>]</div></dd><dt>12.</dt><dd><div class="bk_ref" id="Capromab111In.REF.12">Silver D.A. , Pellicer I. , Fair W.R. , Heston W.D. , Cordon-Cardo C. Prostate-specific membrane antigen expression in normal and malignant human tissues. <span><span class="ref-journal">Clin Cancer Res. </span>1997;<span class="ref-vol">
|
||
<strong>3</strong>
|
||
</span>(1):81–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9815541" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9815541</span></a>]</div></dd><dt>13.</dt><dd><div class="bk_ref" id="Capromab111In.REF.13">Sweat S.D. , Pacelli A. , Murphy G.P. , Bostwick D.G. Prostate-specific membrane antigen expression is greatest in prostate adenocarcinoma and lymph node metastases. <span><span class="ref-journal">Urology. </span>1998;<span class="ref-vol">
|
||
<strong>52</strong>
|
||
</span>(4):637–40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9763084" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9763084</span></a>]</div></dd><dt>14.</dt><dd><div class="bk_ref" id="Capromab111In.REF.14">Troyer J.K. , Beckett M.L. , Wright G.L. Detection and characterization of the prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. <span><span class="ref-journal">Int J Cancer. </span>1995;<span class="ref-vol">
|
||
<strong>62</strong>
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</span>(5):552–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7665226" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7665226</span></a>]</div></dd><dt>15.</dt><dd><div class="bk_ref" id="Capromab111In.REF.15">Liu H. , Moy P. , Kim S. , Xia Y. , Rajasekaran A. , Navarro V. , Knudsen B. , Bander N.H. Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. <span><span class="ref-journal">Cancer Res. </span>1997;<span class="ref-vol">
|
||
<strong>57</strong>
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||
</span>(17):3629–34.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9288760" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9288760</span></a>]</div></dd><dt>16.</dt><dd><div class="bk_ref" id="Capromab111In.REF.16">Chang S.S. , O'Keefe D.S. , Bacich D.J. , Reuter V.E. , Heston W.D. , Gaudin P.B. Prostate-specific membrane antigen is produced in tumor-associated neovasculature. <span><span class="ref-journal">Clin Cancer Res. </span>1999;<span class="ref-vol">
|
||
<strong>5</strong>
|
||
</span>(10):2674–81.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10537328" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10537328</span></a>]</div></dd><dt>17.</dt><dd><div class="bk_ref" id="Capromab111In.REF.17">Mardirossian G. , Brill A.B. , Dwyer K.M. , Kahn D. , Nelp W. Radiation absorbed dose from indium-111-CYT-356. <span><span class="ref-journal">J Nucl Med. </span>1996;<span class="ref-vol">
|
||
<strong>37</strong>
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||
</span>(9):1583–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8790224" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8790224</span></a>]</div></dd><dt>18.</dt><dd><div class="bk_ref" id="Capromab111In.REF.18">Manyak M.J. , Hinkle G.H. , Olsen J.O. , Chiaccherini R.P. , Partin A.W. , Piantadosi S. , Burgers J.K. , Texter J.H. , Neal C.E. , Libertino J.A. , Wright G.L. , Maguire R.T. Immunoscintigraphy with indium-111-capromab pendetide: evaluation before definitive therapy in patients with prostate cancer. <span><span class="ref-journal">Urology. </span>1999;<span class="ref-vol">
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<strong>54</strong>
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</span>(6):1058–63.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10604708" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10604708</span></a>]</div></dd><dt>19.</dt><dd><div class="bk_ref" id="Capromab111In.REF.19">Sodee D.B. , Malguria N. , Faulhaber P. , Resnick M.I. , Albert J. , Bakale G. Multicenter ProstaScint imaging findings in 2154 patients with prostate cancer. The ProstaScint Imaging Centers. <span><span class="ref-journal">Urology. </span>2000;<span class="ref-vol">
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<strong>56</strong>
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</span>(6):988–93.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11113745" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11113745</span></a>]</div></dd><dt>20.</dt><dd><div class="bk_ref" id="Capromab111In.REF.20">Schettino C.J. , Kramer E.L. , Noz M.E. , Taneja S. , Padmanabhan P. , Lepor H. Impact of fusion of indium-111 capromab pendetide volume data sets with those from MRI or CT in patients with recurrent prostate cancer. <span><span class="ref-journal">AJR Am J Roentgenol. </span>2004;<span class="ref-vol">
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<strong>183</strong>
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</span>(2):519–24.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15269050" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15269050</span></a>]</div></dd><dt>21.</dt><dd><div class="bk_ref" id="Capromab111In.REF.21">Wong T.Z. , Turkington T.G. , Polascik T.J. , Coleman R.E. ProstaScint (capromab pendetide) imaging using hybrid gamma camera-CT technology. <span><span class="ref-journal">AJR Am J Roentgenol. </span>2005;<span class="ref-vol">
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<strong>184</strong>
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</span>(2):676–80.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15671397" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15671397</span></a>]</div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK23237</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/20641439" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">20641439</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/Z1907-BZ-DPTA111In/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/Mindin19G9-111In/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK23237/?report=reader">PubReader</a></li><li><a href="/books/NBK23237/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK23237" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK23237" style="display:none" title="Cite this Page"><div class="bk_tt">Leung K. 111In-Capromab pendetide. 2005 Oct 5 [Updated 2008 May 24]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK23237/pdf/Bookshelf_NBK23237.pdf">PDF version of this page</a> (139K)</li><li><a href="/books/n/micad/toc/bin/micad.csv">MICAD summary (CSV file)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#Capromab111In.Background" ref="log$=inpage&link_id=inpage">Background</a></li><li><a href="#Capromab111In.Synthesis" ref="log$=inpage&link_id=inpage">Synthesis</a></li><li><a href="#Capromab111In.In_Vitro_Studies_Tes" ref="log$=inpage&link_id=inpage"><i>In Vitro</i> Studies: Testing in Cells and Tissues</a></li><li><a href="#Capromab111In.Animal_Studies" ref="log$=inpage&link_id=inpage">Animal Studies</a></li><li><a href="#Capromab111In.Human_Studies" ref="log$=inpage&link_id=inpage">Human Studies</a></li><li><a href="#Capromab111In.references" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Search MICAD</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-application" id="Shutter"></a></div><div class="portlet_content"><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmSearch" method="get" action="/books/NBK5330/" id="frmSearch"><script type="text/javascript" src="/corehtml/pmc//js/bookshelf/micad.js">/**/</script><label class="offscreen_noflow" for="txtfield">Search term</label><input id="txtfield" type="text" name="f1_term" size="22" onKeyPress="KeyPress('micad',event,'/books/NBK5330/','')" /><button name="f1_search" type="submit">Go</button><button onclick="this.form.reset();" type="reset">Clear</button><p><b>Limit my Search:</b></p><div class="clearfix"><label for="detection">Method of detection:</label><div class="right"><select name="detection" id="detection" style="width:200px"><option value="" selected="selected">Any</option><option value="(MRI OR "Magnetic resonance imaging" OR MRS)">MRI</option><option value="Multimodal">Multimodal imaging</option><option value="Optical">Optical imaging</option><option value="PET">PET</option><option value="Photoacoustic">Photoacoustic imaging</option><option value="(SPECT OR planar)">SPECT</option><option value="Ultrasound">Ultrasound</option><option value="(x-ray OR ct)">X-ray, CT</option></select></div></div><div class="clearfix"><label for="signal">Source of signal/contrast:</label><div class="right"><select name="signal" id="signal" style="width:200px"><option value="" selected="selected">Any</option><optgroup label="MRI agents"><option value="(Copper OR Cu)">Copper</option><option value="(Europium OR Eu3+)">Europium</option><option value="(Fluorine OR 19F)">Fluorine</option><option value="(Gadolinium OR Gd3+)">Gadolinium</option><option value=""Hyperpolarized 13C"">Hyperpolarized 13C</option><option value=""Iron oxide"">Iron oxide</option><option value=""Nitroxide radicals"">Nitroxide radicals</option><option value="(Oxygen OR 17O)">Oxygen</option><option value="Thulium">Thulium</option></optgroup><optgroup label="Multimodal agents"><option value="((Gadolinium OR Gd3+) AND Optical)">Gadolinium and optical</option><option value="((Gadolinium OR Gd3+) AND (Gold OR Au))">Gadolinium and Gold</option><option value="("Iron oxide" AND (64Cu OR 124I OR 111In))">Iron oxide and
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<div class="row">
|
||
<div class="col-lg-12 centered-lg">
|
||
<nav class="bottom-links">
|
||
<ul class="mt-3">
|
||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
|
||
</li>
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||
<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
</ul>
|
||
</nav>
|
||
</div>
|
||
</div>
|
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</div>
|
||
</section>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
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<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
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</div>
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||
</div>
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||
</div>
|
||
<!--/.page-->
|
||
</div>
|
||
<!--/.wrap-->
|
||
</div><!-- /.twelve_col -->
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||
</div>
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||
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||
|
||
<span class="PAFAppResources"></span>
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||
|
||
<!-- BESelector tab -->
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||
|
||
|
||
|
||
<noscript><img alt="statistics" src="/stat?jsdisabled=true&ncbi_db=books&ncbi_pdid=book-part&ncbi_acc=NBK23237&ncbi_domain=micad&ncbi_report=record&ncbi_type=fulltext&ncbi_objectid=&ncbi_pcid=/NBK23237/&ncbi_pagename=111In-Capromab pendetide - Molecular Imaging and Contrast Agent Database (MICAD) - NCBI Bookshelf&ncbi_bookparttype=chapter&ncbi_app=bookshelf" /></noscript>
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<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
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<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3879255/4121861/3501987/4008961/3893018/3821238/4062932/4209313/4212053/4076480/3921943/3400083/3426610.js" snapshot="books"></script></body>
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