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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/micad/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-micad-lrg.png" alt="Cover of Molecular Imaging and Contrast Agent Database (MICAD)" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Molecular Imaging and Contrast Agent Database (MICAD) [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK23602_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK23602_dtls__"><div>Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>; 2004-2013.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/micad/">Contents</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/micad/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/RM1-DOTA-111In/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/DPC11870In111/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK23602_"><span class="title" itemprop="name"><sup>111</sup>In-DOTA-Re(Cys<sup>3,4,10</sup>,<span class="small-caps">d</span>-Phe<sup>7</sup>,Arg<sup>11</sup>)αMSH<sub>3-13</sub></span></h1><div itemprop="alternativeHeadline" class="subtitle whole_rhythm"><sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)CCMSH</div><p class="contrib-group"><span itemprop="author">Kenneth T. Cheng</span>, PhD, <span itemprop="author">Zhen Cheng</span>, PhD, and <span itemprop="author">Thomas P. Quinn</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK23602_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK23602_ai__"><div class="contrib half_rhythm"><span itemprop="author">Kenneth T. Cheng</span>, PhD<div class="affiliation small">
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||
National Center for Biotechnology Information, NLM, NIH, Bethesda, MD,
|
||
<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@dacim" class="oemail">vog.hin.mln.ibcn@dacim</a>
|
||
</div></div><div class="contrib half_rhythm"><span itemprop="author">Zhen Cheng</span>, PhD<div class="affiliation small">
|
||
Molecular Imaging Program, Department of Radiology and Bio-X Program, Stanford University, CA,
|
||
<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ude.drofnats@gnehz" class="oemail">ude.drofnats@gnehz</a>
|
||
</div></div><div class="contrib half_rhythm"><span itemprop="author">Thomas P. Quinn</span>, PhD<div class="affiliation small">
|
||
Department of Biochemistry, University of Missouri-Columbia, Columbia, MO, Corresponding Author,
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<span class="before-email-separator"></span><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ude.iruossim@tnniuq" class="oemail">ude.iruossim@tnniuq</a>
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</div></div></div><p class="small">Created: <span itemprop="datePublished">September 1, 2007</span>; Last Update: <span itemprop="dateModified">December 17, 2007</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="CCMSH111In.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK23602/table/CCMSH111In.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__CCMSH111In.T1_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Chemical name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)(Cys<sup>3,4,10</sup>,<span class="small-caps">d</span>-Phe<sup>7</sup>)-αMSH<sub>3-13</sub></td><td rowspan="9" colspan="1" style="text-align:left;vertical-align:middle;">
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<div class="graphic"><img src="/books/NBK23602/bin/CCMSH111In.jpg" alt="Image CCMSH111In.jpg" /></div>
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</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Abbreviated name:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)CCMSH</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Synonym:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-α-MSH, <sup>111</sup>In-labeled α-melanocyte–stimulating hormone peptides</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Agent Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Peptide</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Melanocortin-1 (MC-1) receptor</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Target Category:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Peptide-receptor binding</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Method of detection:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Single-photon emission computed tomography (SPECT) or gamma planar imaging</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Source of signal:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Activation:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No</td></tr><tr><td rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
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<b>Studies:</b>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" />
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<i>In vitro</i>
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</div></li></ul>
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<ul class="simple-list"><li class="half_rhythm"><div>
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<img alt="Checkbox" src="/corehtml/pmc/css/bookshelf/2.26/img/studies.checkbox.png" /> Rodents
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</div></li></ul>
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</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><sup>111</sup>In-DOTA- Re(Arg<sup>11</sup>)CCMSH.<br />Click on <a href="/entrez/viewer.fcgi?db=protein&val=27477129" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">protein</a>, <a href="/entrez/viewer.fcgi?db=nucleotide&val=27477128" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">nucleotide</a> (RefSeq), and <a href="/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=4157" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">gene</a> for more information about the melanocortin-1 receptor.</td></tr></tbody></table></div></div><div id="CCMSH111In.Background"><h2 id="_CCMSH111In_Background_">Background</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%2899mTc-%20and%20111In-labeled%20alpha-melanocyte-stimulating%20hormone%20peptides%29%20OR%20%28radiolabeled-alpha-MSH%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p><sup>111</sup>In-DOTA-[Cys<sup>3,4,10</sup>,<span class="small-caps">d</span>-Phe<sup>7</sup>,Arg<sup>11</sup>]αMSH<sub>3-13</sub> (<sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)CCMSH) is a radioligand developed as an imaging probe for single-photon emission computed tomography (SPECT) of primary and metastatic melanoma (<a class="bk_pop" href="#CCMSH111In.EXTYLES.1">1</a>, <a class="bk_pop" href="#CCMSH111In.EXTYLES.2">2</a>). <sup>111</sup>In is a gamma emitter with a physical half-life (<i>t</i><sub>½</sub>) of 2.8 days.</p><p>Malignant melanoma is the sixth most common cancer in the United States (<a class="bk_pop" href="#CCMSH111In.EXTYLES.2">2</a>). Early diagnosis and prompt surgical removal is the best approach for treatment (<a class="bk_pop" href="#CCMSH111In.EXTYLES.2">2</a>, <a class="bk_pop" href="#CCMSH111In.EXTYLES.3">3</a>). The melanocortin (MC) system is the best characterized neuropeptide network of the skin, and it is involved in pigmentation regulation, cortisol production, and many other physiological processes (<a class="bk_pop" href="#CCMSH111In.EXTYLES.4">4</a>). Most cutaneous cell types express MC receptors, proopiomelanocortin (POMC), and prohormone convertases, and they also release MCs. Five MC receptors (MC-1 to MC-5) have been cloned and characterized as receptors that belong to the G-protein–coupled receptor superfamily. The melanocyte-stimulating hormones (MSHs) α-, β-, and γ-MSH are derived from POMC by the proteolytic action of prohormone convertases. α-MSH (Ac-Ser<sup>1</sup>-Tyr<sup>2</sup>-Ser<sup>3</sup>-Met<sup>4</sup>-Glu<sup>5</sup>-His<sup>6</sup>-Phe<sup>7</sup>-Arg<sup>8</sup>-Trp<sup>9</sup>-Gly<sup>10</sup>-Lys<sup>11</sup>-Pro<sup>12</sup>-Val<sup>13</sup>-NH<sub>2</sub>), composed of 13 amino acids, is the most potent naturally occurring melanotropic peptide (<a class="bk_pop" href="#CCMSH111In.EXTYLES.5">5</a>). The biologic effects of α-MSH are mediated <i>via</i> MC receptors.</p><p>Although positron emission tomography imaging with [<sup>18</sup>F]fluoro-2-deoxy-2-<span class="small-caps">d</span>-glucose ([<sup>18</sup>F]FDG) is effective in the detection of melanoma, it is not melanoma-specific and some melanoma cells do not take up [<sup>18</sup>F]FDG (<a class="bk_pop" href="#CCMSH111In.EXTYLES.6">6</a>, <a class="bk_pop" href="#CCMSH111In.EXTYLES.7">7</a>). Radiolabeled α-MSH peptide analogs have been shown to specifically bind to MC-1 receptors that are overexpressed on human and mouse melanoma cells (<a class="bk_pop" href="#CCMSH111In.EXTYLES.8">8-11</a>). Giblin et al. (<a class="bk_pop" href="#CCMSH111In.EXTYLES.12">12</a>) used metal cyclization to design a new class of α-MSH peptide analogs that are resistant to chemical and proteolytic degradation <i>in vivo</i>. α-MSH analogs were cyclized through site-specific rhenium (Re) metal coordination to form Re[(Cys<sup>3,4,10</sup>,<span class="small-caps">d</span>-Phe<sup>7</sup>)αMSH<sub>3-13</sub> (ReCCMSH). ReCCMSH displayed a receptor-binding affinity of 2.9 nM, 25-fold higher than the Re-CMSH analog. Additional studies have reported successful use of 1,4,7,10-tetraazacyclodecane-<i>N</i>,<i>N'</i>,<i>N''</i>,<i>N'''</i>-tetraacetic acid (DOTA) coupled to the cyclic ReCCMSH peptide analogs (<a class="bk_pop" href="#CCMSH111In.EXTYLES.1">1</a>, <a class="bk_pop" href="#CCMSH111In.EXTYLES.13">13</a>) and linear α-MSH analogs (<a class="bk_pop" href="#CCMSH111In.EXTYLES.14">14-16</a>) for radiolabeling. These α-MSH derivatives (DOTA-α-MSH) were labeled with a variety of radionuclides (<a class="bk_pop" href="#CCMSH111In.EXTYLES.3">3</a>, <a class="bk_pop" href="#CCMSH111In.EXTYLES.12">12</a>, <a class="bk_pop" href="#CCMSH111In.EXTYLES.13">13</a>, <a class="bk_pop" href="#CCMSH111In.EXTYLES.16">16-19</a>). Cheng et al. (<a class="bk_pop" href="#CCMSH111In.EXTYLES.1">1</a>) showed that the kidney uptake of a rhenium cyclized DOTA-α-MSH analog [DOTA-Re(Arg<sup>11</sup>)CCMSH] could be considerably reduced and tumor uptake could be enhanced significantly by substitution the Lys<sup>11</sup> residue with Arg<sup>11</sup> in order to delocalize the charge of the Lys<sup>11</sup> residue. <sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)CCMSH showed favorable tumor imaging properties in mice bearing murine melanoma (<a class="bk_pop" href="#CCMSH111In.EXTYLES.2">2</a>). Miao et al. (<a class="bk_pop" href="#CCMSH111In.EXTYLES.11">11</a>) also replaced the Lys<sup>11</sup> with Arg<sup>11</sup> in the ReCCMSH analog to form Re(Arg<sup>11</sup>)CCMSH in an effort to reduce nonspecific kidney uptake and minimize the kidney radiation dose. Linear MSH analogs, conjugated with DOTA, also demonstrated melanoma tumor targeting. Chen et al. (<a class="bk_pop" href="#CCMSH111In.EXTYLES.14">14</a>) demonstrated moderate tumor uptake of the MSH analog <sup>111</sup>In-DOTA-NDP. Eberle and Froidevaux (<a class="bk_pop" href="#CCMSH111In.EXTYLES.15">15</a>) prepared a minimal α-MSH analog <sup>111</sup>In-DOTA-MSH<sub>OCT</sub> that showed good <i>in vitro</i> and <i>in vivo</i> targeting properties. Froidevaux et al. (<a class="bk_pop" href="#CCMSH111In.EXTYLES.16">16</a>) changed the location of DOTA conjugation to Lys<sup>11</sup> yielding DOTA-NAPamide with reduced kidney uptake by neutralizing the charge of the Lys residue. While these linear DOTA-MSH analogs exhibited tumor uptake and rapid clearance, they did not achieve the percent dose per gram and retention time of the cyclic DOTA-MSH peptides.</p></div><div id="CCMSH111In.Synthesis"><h2 id="_CCMSH111In_Synthesis_">Synthesis</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%2899mTc-%20and%20111In-labeled%20alpha-melanocyte-stimulating%20hormone%20peptides%29%20OR%20%28radiolabeled-alpha-MSH%29%20AND%20synthesis" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Cheng et al (<a class="bk_pop" href="#CCMSH111In.EXTYLES.1">1</a>) and Miao et al. (<a class="bk_pop" href="#CCMSH111In.EXTYLES.17">17</a>) reported the synthesis of the DOTA-(Arg<sup>11</sup>)CCMSH using the standard fluorenylmethoxycarbonyl (Fmoc)/HBTU chemistry on amide resin. A solid-phase peptide synthesizer was used. DOTA-tri-<i>t</i>-butyl ester was coupled to the <i>N</i>-terminus of the peptide during the terminal round of synthesis. The peptide was deprotected and cleaved from the resin by a mixture of trifluoroacetic acid, thioanisol, ethanedithiol, and water at room temperature for 3 h. DOTA-Re(Arg<sup>11</sup>)CCMSH was cyclized by site-specific Re coordination. DOTA-Re(Arg<sup>11</sup>)CCMSH and ReOCl<sub>3</sub>(Me<sub>2</sub>S)(OPPh<sub>3</sub>) were dissolved in 60% methanol aqueous solution (1:1.5 molar ratio). The pH was adjusted to ~8, and the mixture was incubated at 70ºC for 1 h. DOTA-Re(Arg<sup>11</sup>)CCMSH was collected by centrifugation and purified by high-performance liquid chromatography (HPLC) (<a class="bk_pop" href="#CCMSH111In.EXTYLES.13">13</a>). Radiolabeling with <sup>111</sup>In was performed by mixing <sup>111</sup>In-chloride in ammonium acetate with 10 μg peptide and incubating at 70ºC for 45 min. <sup>111</sup>In-DOTA-(Arg<sup>11</sup>)CCMSH was purified by HPLC. The specific activity was reported to be 8.1164 × 10<sup>8</sup> MBq/g (2.1936 × 10<sup>7</sup> mCi/g). On the basis of the peptide molecular weight of ~1990, the specific activity was ~1.6152 × 10<sup>10</sup> MBq/μmol (4.3654 × 10<sup>8</sup> mCi/ μmol).</p></div><div id="CCMSH111In.In_Vitro_Studies_Tes"><h2 id="_CCMSH111In_In_Vitro_Studies_Tes_"><i>In Vitro</i> Studies: Testing in Cells and Tissues</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%2899mTc-%20and%20111In-labeled%20alpha-melanocyte-stimulating%20hormone%20peptides%29%20OR%20%28radiolabeled-alpha-MSH%29%29%20AND%20in%20vitro" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Cheng et al. (<a class="bk_pop" href="#CCMSH111In.EXTYLES.1">1</a>) performed <i>in vitro</i> quantitative receptor-binding assays of unlabeled CCMSH on B16/F1 murine melanoma cells. The inhibition constant (<i>K</i><sub>i</sub>) was determined to be 7.6 × 10−<sup>9</sup> M. Chen et al. (<a class="bk_pop" href="#CCMSH111In.EXTYLES.13">13</a>) determined the 50% inhibiton concentration IC<sub>50</sub> of unlabeled DOTA-ReCCMSH to be 1.2 ± 0.3 nmol/liter. In comparison, the IC<sub>50</sub> of unlabeled ReCCMSH was 2.9 ± 0.3 nmol/liter (<a class="bk_pop" href="#CCMSH111In.EXTYLES.12">12</a>).</p></div><div id="CCMSH111In.Animal_Studies"><h2 id="_CCMSH111In_Animal_Studies_">Animal Studies</h2><div id="CCMSH111In.Rodents"><h3>Rodents</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%2899mTc-%20and%20111In-labeled%20alpha-melanocyte-stimulating%20hormone%20peptides%29%20OR%20%28radiolabeled-alpha-MSH%29%29%20AND%20rodentia" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>Biodistribution and SPECT imaging studies with <sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)CCMSH were conducted in C57 mice bearing B16/F1 (flank melanoma tumors) (<a class="bk_pop" href="#CCMSH111In.EXTYLES.1">1</a>, <a class="bk_pop" href="#CCMSH111In.EXTYLES.2">2</a>) and B16/F10 (pulmonary metastatic melanoma tumors) tumors (<a class="bk_pop" href="#CCMSH111In.EXTYLES.2">2</a>). Each mouse received 20.35 MBq (0.55 mCi) of <sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)CCMSH by intravenous administration. The radioactivity levels as percentage injected dose per g (% ID/g) in the flank tumors (<i>n</i> = 4) were 17.29 ± 2.49 (2 h), 17.41 ± 5.63 (4 h), and 8.19 ± 1.63 (24 h). The tumor/muscle ratios were 576.33 (2 h), 193.44 (4 h), and 58.50 (24 h). The critical organ appeared to be the kidneys with 8.72 ± 1.34 (2 h), 7.73 ± 1.13 (4 h), and 5.64 ± 0.52 (24 h). The tumor/kidney ratios were 1.98 (2 h), 2.36 (4 h), and 1.45 (24 h). Approximately 90% ID/g was cleared from the body in 4 h. The other major organ radioactivity levels (% ID/g) at 2 h were 0.40 ± 0.04 (intestines), 0.23 ± 0.05 (stomach), 0.38 ± 0.04 (liver), 0.30 ± 0.09 (lung), 0.35 ± 0.18 (skin), 0.07 ± 0.09 (heart), 0.03 ± 0.04 (brain), 0.03 ± 0.03 (muscle), and 0.21 ± 0.08 (blood). <sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)CCMSH appeared to exhibit faster whole-body clearance and significantly higher 24-h tumor radioactivity level than <sup>99m</sup>Tc-(Arg<sup>11</sup>)CCMSH.</p><p>In the pulmonary metastatic tumor model, the radioactivity levels (% ID/g) of <sup>111</sup>In-DOTA-Re(Arg<sup>11</sup>)CCMSH in the lung metastases (<i>n</i> = 4) were 9.10 ± 2.86 (2 h) and 7.75 ± 3.66 (4 h) (<a class="bk_pop" href="#CCMSH111In.EXTYLES.2">2</a>). The radioactivity levels (% ID/g) in the normal lung were 0.23 ± 0.05 (2 h) and 0.08 ± 0.03 (4 h). The lung metastases/normal lung ratios were 39.57 and 96.88 at 2 h and 4 h, respectively. The lung metastases/muscle ratios were 130.00 and 193.75 at 2 h and 4 h, respectively. In the imaging studies that fused SPECT images with images of computed tomography, the flank melanoma tumors were visualized clearly at 2 h. The pulmonary metastatic melanoma lesions were also clearly imaged at 2 h, and distinct metastatic focal deposits were visible.</p></div><div id="CCMSH111In.Other_NonPrimate_Mam"><h3>Other Non-Primate Mammals</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%2899mTc-%20and%20111In-labeled%20alpha-melanocyte-stimulating%20hormone%20peptides%29%20AND%20%28dog%20OR%20rabbit%20OR%20pig%20OR%20sheep%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="CCMSH111In.NonHuman_Primates"><h3>Non-Human Primates</h3><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%2899mTc-%20and%20111In-labeled%20alpha-melanocyte-stimulating%20hormone%20peptides%29%20OR%20%28radiolabeled-alpha-MSH%29%29%20AND%20%28primate%20NOT%20human%29" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div></div><div id="CCMSH111In.Human_Studies"><h2 id="_CCMSH111In_Human_Studies_">Human Studies</h2><p>[<a href="/entrez/query.fcgi?cmd=PureSearch&db=pubmed&details_term=%28%2899mTc-%20and%20111In-labeled%20alpha-melanocyte-stimulating%20hormone%20peptides%29%20OR%20%28radiolabeled-alpha-MSH%29%29%20AND%20human" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed</a>]</p><p>No publication is currently available.</p></div><div id="CCMSH111In.NIH_Support"><h2 id="_CCMSH111In_NIH_Support_">NIH Support</h2><p>NCI R41 A85106, P50-CA-130130</p></div><div id="CCMSH111In.references"><h2 id="_CCMSH111In_references_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.1">Cheng Z. , Chen J. , Miao Y. , Owen N.K. , Quinn T.P. , Jurisson S.S. Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues. <span><span class="ref-journal">J Med Chem. </span>2002;<span class="ref-vol">
|
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<strong>45</strong>
|
||
</span>(14):3048–56.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12086490" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12086490</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.2">Miao Y. , Benwell K. , Quinn T.P. 99mTc- and 111In-labeled alpha-melanocyte-stimulating hormone peptides as imaging probes for primary and pulmonary metastatic melanoma detection. <span><span class="ref-journal">J Nucl Med. </span>2007;<span class="ref-vol">
|
||
<strong>48</strong>
|
||
</span>(1):73–80.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17204701" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17204701</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.3">Miao Y. , Hylarides M. , Fisher D.R. , Shelton T. , Moore H. , Wester D.W. , Fritzberg A.R. , Winkelmann C.T. , Hoffman T. , Quinn T.P. Melanoma therapy via peptide-targeted {alpha}-radiation. <span><span class="ref-journal">Clin Cancer Res. </span>2005;<span class="ref-vol">
|
||
<strong>11</strong>
|
||
</span>(15):5616–21.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16061880" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16061880</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.4">Bohm M. , Luger T.A. , Tobin D.J. , Garcia-Borron J.C. Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. <span><span class="ref-journal">J Invest Dermatol. </span>2006;<span class="ref-vol">
|
||
<strong>126</strong>
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||
</span>(9):1966–75.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16912693" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16912693</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.5">Catania A. , Airaghi L. , Garofalo L. , Cutuli M. , Lipton J.M. The neuropeptide alpha-MSH in HIV infection and other disorders in humans. <span><span class="ref-journal">Ann N Y Acad Sci. </span>1998;<span class="ref-vol">
|
||
<strong>840</strong>
|
||
</span>:848–56.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/9629310" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9629310</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.6">Dimitrakopoulou-Strauss A. , Strauss L.G. , Burger C. Quantitative PET studies in pretreated melanoma patients: a comparison of 6-[18F]fluoro-L-dopa with 18F-FDG and (15)O-water using compartment and noncompartment analysis. <span><span class="ref-journal">J Nucl Med. </span>2001;<span class="ref-vol">
|
||
<strong>42</strong>
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||
</span>(2):248–56.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11216523" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11216523</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.7">Weiner R.E. , Thakur M.L. Radiolabeled peptides in oncology: role in diagnosis and treatment. <span><span class="ref-journal">BioDrugs. </span>2005;<span class="ref-vol">
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||
<strong>19</strong>
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||
</span>(3):145–63.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15984900" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15984900</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.8">Tatro J.B. , Reichlin S. Specific receptors for alpha-melanocyte-stimulating hormone are widely distributed in tissues of rodents. <span><span class="ref-journal">Endocrinology. </span>1987;<span class="ref-vol">
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||
<strong>121</strong>
|
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</span>(5):1900–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2822378" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2822378</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.9">Siegrist W. , Solca F. , Stutz S. , Giuffre L. , Carrel S. , Girard J. , Eberle A.N. Characterization of receptors for alpha-melanocyte-stimulating hormone on human melanoma cells. <span><span class="ref-journal">Cancer Res. </span>1989;<span class="ref-vol">
|
||
<strong>49</strong>
|
||
</span>(22):6352–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/2804981" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2804981</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.10">Chen J. , Cheng Z. , Hoffman T.J. , Jurisson S.S. , Quinn T.P. Melanoma-targeting properties of (99m)technetium-labeled cyclic alpha-melanocyte-stimulating hormone peptide analogues. <span><span class="ref-journal">Cancer Res. </span>2000;<span class="ref-vol">
|
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<strong>60</strong>
|
||
</span>(20):5649–58.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11059756" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11059756</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.11">Miao Y. , Whitener D. , Feng W. , Owen N.K. , Chen J. , Quinn T.P. Evaluation of the human melanoma targeting properties of radiolabeled alpha-melanocyte stimulating hormone peptide analogues. <span><span class="ref-journal">Bioconjug Chem. </span>2003;<span class="ref-vol">
|
||
<strong>14</strong>
|
||
</span>(6):1177–84.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14624632" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14624632</span></a>]</div></dd><dt>12.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.12">Giblin M.F. , Wang N. , Hoffman T.J. , Jurisson S.S. , Quinn T.P. Design and characterization of alpha-melanotropin peptide analogs cyclized through rhenium and technetium metal coordination. <span><span class="ref-journal">Proc Natl Acad Sci U S A. </span>1998;<span class="ref-vol">
|
||
<strong>95</strong>
|
||
</span>(22):12814–8.</span> [<a href="/pmc/articles/PMC23606/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC23606</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/9788997" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9788997</span></a>]</div></dd><dt>13.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.13">Chen J. , Cheng Z. , Owen N.K. , Hoffman T.J. , Miao Y. , Jurisson S.S. , Quinn T.P. Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties. <span><span class="ref-journal">J Nucl Med. </span>2001;<span class="ref-vol">
|
||
<strong>42</strong>
|
||
</span>(12):1847–55.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11752084" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11752084</span></a>]</div></dd><dt>14.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.14">Chen J. , Cheng Z. , Miao Y. , Jurisson S.S. , Quinn T.P. <span class="ref-title">Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting </span><span class="ref-journal">Cancer</span> 2002<strong>94</strong>Suppl4:1196–201. [<a href="https://pubmed.ncbi.nlm.nih.gov/11877745" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11877745</span></a>]</div></dd><dt>15.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.15">Eberle A.N. , Froidevaux S. Radiolabeled alpha-melanocyte-stimulating hormone analogs for receptor-mediated targeting of melanoma: from tritium to indium. <span><span class="ref-journal">J Mol Recognit. </span>2003;<span class="ref-vol">
|
||
<strong>16</strong>
|
||
</span>(5):248–54.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14523936" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14523936</span></a>]</div></dd><dt>16.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.16">Froidevaux S. , Calame-Christe M. , Tanner H. , Eberle A.N. Melanoma targeting with DOTA-alpha-melanocyte-stimulating hormone analogs: structural parameters affecting tumor uptake and kidney uptake. <span><span class="ref-journal">J Nucl Med. </span>2005;<span class="ref-vol">
|
||
<strong>46</strong>
|
||
</span>(5):887–95.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15872364" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15872364</span></a>]</div></dd><dt>17.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.17">Miao Y. , Owen N.K. , Whitener D. , Gallazzi F. , Hoffman T.J. , Quinn T.P. In vivo evaluation of 188Re-labeled alpha-melanocyte stimulating hormone peptide analogs for melanoma therapy. <span><span class="ref-journal">Int J Cancer. </span>2002;<span class="ref-vol">
|
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<strong>101</strong>
|
||
</span>(5):480–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12216078" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12216078</span></a>]</div></dd><dt>18.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.18">Froidevaux S. , Calame-Christe M. , Schuhmacher J. , Tanner H. , Saffrich R. , Henze M. , Eberle A.N. A gallium-labeled DOTA-alpha-melanocyte- stimulating hormone analog for PET imaging of melanoma metastases. <span><span class="ref-journal">J Nucl Med. </span>2004;<span class="ref-vol">
|
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<strong>45</strong>
|
||
</span>(1):116–23.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14734683" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14734683</span></a>]</div></dd><dt>19.</dt><dd><div class="bk_ref" id="CCMSH111In.EXTYLES.19">Miao Y. , Hoffman T.J. , Quinn T.P. Tumor-targeting properties of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues in a murine melanoma model. <span><span class="ref-journal">Nucl Med Biol. </span>2005;<span class="ref-vol">
|
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<strong>32</strong>
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</span>(5):485–93.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15982579" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15982579</span></a>]</div></dd></dl></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><div>This MICAD chapter is not included in the Open Access Subset, because it was authored / co-authored by one or more investigators who was not a member of the MICAD staff.</div></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK23602</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/20641798" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">20641798</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/micad/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/micad/RM1-DOTA-111In/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/micad/DPC11870In111/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK23602/?report=reader">PubReader</a></li><li><a href="/books/NBK23602/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK23602" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK23602" style="display:none" title="Cite this Page"><div class="bk_tt">Cheng KT, Cheng Z, Quinn TP. 111In-DOTA-Re(Cys3,4,10,d-Phe7,Arg11)αMSH3-13. 2007 Sep 1 [Updated 2007 Dec 17]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. <span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK23602/pdf/Bookshelf_NBK23602.pdf">PDF version of this page</a> (407K)</li><li><a href="/books/n/micad/toc/bin/micad.csv">MICAD summary (CSV file)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#CCMSH111In.Background" ref="log$=inpage&link_id=inpage">Background</a></li><li><a href="#CCMSH111In.Synthesis" ref="log$=inpage&link_id=inpage">Synthesis</a></li><li><a href="#CCMSH111In.In_Vitro_Studies_Tes" ref="log$=inpage&link_id=inpage"><i>In Vitro</i> Studies: Testing in Cells and Tissues</a></li><li><a href="#CCMSH111In.Animal_Studies" ref="log$=inpage&link_id=inpage">Animal Studies</a></li><li><a href="#CCMSH111In.Human_Studies" ref="log$=inpage&link_id=inpage">Human Studies</a></li><li><a href="#CCMSH111In.NIH_Support" ref="log$=inpage&link_id=inpage">NIH Support</a></li><li><a href="#CCMSH111In.references" ref="log$=inpage&link_id=inpage">References</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Search MICAD</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-application" id="Shutter"></a></div><div class="portlet_content"><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmSearch" method="get" action="/books/NBK5330/" id="frmSearch"><script type="text/javascript" src="/corehtml/pmc//js/bookshelf/micad.js">/**/</script><label class="offscreen_noflow" for="txtfield">Search term</label><input id="txtfield" type="text" name="f1_term" size="22" onKeyPress="KeyPress('micad',event,'/books/NBK5330/','')" /><button name="f1_search" type="submit">Go</button><button onclick="this.form.reset();" type="reset">Clear</button><p><b>Limit my Search:</b></p><div class="clearfix"><label for="detection">Method of detection:</label><div class="right"><select name="detection" id="detection" style="width:200px"><option value="" selected="selected">Any</option><option value="(MRI OR "Magnetic resonance imaging" OR MRS)">MRI</option><option value="Multimodal">Multimodal imaging</option><option value="Optical">Optical imaging</option><option value="PET">PET</option><option value="Photoacoustic">Photoacoustic imaging</option><option value="(SPECT OR planar)">SPECT</option><option value="Ultrasound">Ultrasound</option><option value="(x-ray OR ct)">X-ray, CT</option></select></div></div><div class="clearfix"><label for="signal">Source of signal/contrast:</label><div class="right"><select name="signal" id="signal" style="width:200px"><option value="" selected="selected">Any</option><optgroup label="MRI agents"><option value="(Copper OR Cu)">Copper</option><option value="(Europium OR Eu3+)">Europium</option><option value="(Fluorine OR 19F)">Fluorine</option><option value="(Gadolinium OR Gd3+)">Gadolinium</option><option value=""Hyperpolarized 13C"">Hyperpolarized 13C</option><option value=""Iron oxide"">Iron oxide</option><option value=""Nitroxide radicals"">Nitroxide radicals</option><option value="(Oxygen OR 17O)">Oxygen</option><option value="Thulium">Thulium</option></optgroup><optgroup label="Multimodal agents"><option value="((Gadolinium OR Gd3+) AND Optical)">Gadolinium and optical</option><option value="((Gadolinium OR Gd3+) AND (Gold OR Au))">Gadolinium and Gold</option><option value="("Iron oxide" AND (64Cu OR 124I OR 111In))">Iron oxide and
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/><label for="__micad_btn_6">Any</label></div></form><form xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="frmGo" method="get" action="javascript:alert('frmGo:_@action_was_not_set')" id="frmGo"><input name="term" value="." type="hidden" /></form></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pmc&DbFrom=books&Cmd=Link&LinkName=books_pmc_refs&IdsFromResult=1509140" ref="log$=recordlinks">PMC</a><div class="brieflinkpop offscreen_noflow">PubMed Central citations</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" 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offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (99m)Tc-[Cys(3,4,10),d-Phe(7),Arg(11)]α-MSH(3-13).<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT, Quinn TP. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641691" ref="ordinalpos=1&linkpos=2&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (99m)Tc-[Ac-CCEHdFRWCKPV-NH(2)].</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (99m)Tc-[Ac-CCEHdFRWCKPV-NH(2)].<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641724" ref="ordinalpos=1&linkpos=3&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [(18)F]FB-(Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH(2)).</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [(18)F]FB-(Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH(2)).<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT, Gambhir S, Cheng Z. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641555" ref="ordinalpos=1&linkpos=4&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [NIe(4),Asp(5),d-Phe(7), (67)Ga/(68)Ga-1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-1,4,7,10-tetraacetic acid-Lys(11)]-α-MSH(4-11).</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [NIe(4),Asp(5),d-Phe(7), (67)Ga/(68)Ga-1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-1,4,7,10-tetraacetic acid-Lys(11)]-α-MSH(4-11).<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular Imaging and Contrast Agent Database (MICAD). 2004</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/20641698" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (64)Cu-[Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys(1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid)-NH(2)].</a><span class="source">[Molecular Imaging and Contrast...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> (64)Cu-[Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys(1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid)-NH(2)].<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Cheng KT, Gambhir S, Cheng Z. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Molecular 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