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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="All Drug Records" href="/books/n/livertox/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" alt="Cover of LiverTox" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK548776_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK548776_dtls__"><div>Bethesda (MD): <a href="https://www.niddk.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Diabetes and Digestive and Kidney Diseases</a>; 2012-.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/livertox/">Drug Records</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/livertox/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/livertox/glossary/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/livertox/disclaimer/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK548776_"><span class="title" itemprop="name">DILI Information Resources</span></h1><p class="small">Last Update: <span itemprop="dateModified">April 1, 2021</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="resource.Contents"><h2 id="_resource_Contents_">Contents</h2><ul><li class="half_rhythm"><div>Featured Resources</div></li><li class="half_rhythm"><div>Monitoring Systems</div></li><li class="half_rhythm"><div>Bibliographic</div></li><li class="half_rhythm"><div>Registries and Research</div></li><li class="half_rhythm"><div>Factual</div></li><li class="half_rhythm"><div>Select Review Articles</div></li><li class="half_rhythm"><div>Imaging</div></li><li class="half_rhythm"><div>Promotional Brochure</div></li></ul></div><div id="resource._Featured_Resources"><h2 id="_resource__Featured_Resources_">< Featured Resources ></h2><ul class="first-line-outdent"><li><div class="bk_ref" id="resource.REF.hoofnagle.2019.264">Hoofnagle JH, Björnsson ES. Drug-induced liver injury – types and phenotypes. <span><span class="ref-journal">N Engl J Med. </span>2019;<span class="ref-vol">381</span>(3):264–73.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/31314970" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31314970</span></a>]</div></li><li><div class="bk_ref" id="resource.REF.devarbhavi.2021">Devarbhavi H, Aithal G, Treeprasertsuk S, Takikawa H, Mao Y, Shasthry SM, Hamid S, Tan SS, et al. Asia Pacific Association of Study of Liver. Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines. <span><span class="ref-journal">Hepatol Int. </span>2021 Feb 27;</span> Epub ahead of print. [<a href="https://pubmed.ncbi.nlm.nih.gov/33641080" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33641080</span></a>]</div></li></ul></div><div id="resource.Bibliographic"><h2 id="_resource_Bibliographic_">Bibliographic</h2><ul><li class="half_rhythm"><div><a href="https://pubmed.ncbi.nlm.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubMed – Bibliographic citations and full text from the world's biomedical literature</a><br />National Center for Biotechnology Information, National Library of Medicine</div></li><li class="half_rhythm"><div><a href="https://pubmed.ncbi.nlm.nih.gov/?term=tox%20%5Bsubset%5D%20AND%20" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">TOXLINE – Toxicology focused citations and full text from the world's biomedical literature</a><br />National Center for Biotechnology Information, National Library of Medicine</div></li></ul></div><div id="resource.Factual"><h2 id="_resource_Factual_">Factual</h2><ul><li class="half_rhythm"><div><b>FDA DILI Conference –</b>
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<i>See</i>
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<a href="/books/n/livertox/alert/"><b>Meetings and News</b></a>
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<i>in the LiverTox Sidebar</i><br />The US Food and Drug Administration, Center for Drug Evaluation and Research (FDA/CDER) sponsors an annual Drug-Induced Liver Injury Conference.</div></li><li class="half_rhythm"><div><a href="https://chem.nlm.nih.gov/chemidplus/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ChemIDplus Advanced – Chemical substance information, plus substructure and similarity search capability</a><br />National Library of Medicine, NIH</div></li><li class="half_rhythm"><div><a href="https://dailymed.nlm.nih.gov/dailymed/index.cfm" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">DailyMed – Medication labeling (package inserts) and related product information</a>
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<br />National Library of Medicine, NIH</div></li><li class="half_rhythm"><div><a href="https://www.nccih.nih.gov/health/herbsataglance" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCCIH Herbs at a Glance – Fact sheets about specific herbs or botanicals</a><br />National Center for Complementary and Integrative Health, NIH</div></li><li class="half_rhythm"><div><a href="https://naturalmedicines.therapeuticresearch.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Natural Medicines Comprehensive Database – Evidence-based information on natural medicines</a><br />Therapeutic Research Center, Natural Medicines</div></li><li class="half_rhythm"><div><a href="https://ods.od.nih.gov/factsheets/list-all/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ODS Dietary Supplement Fact Sheets</a><br />Office of <a class="def" href="/books/n/livertox/glossary/def-item/glossary.dietary-supplements/">Dietary Supplements</a>, NIH</div></li></ul></div><div id="resource.Imaging"><h2 id="_resource_Imaging_">Imaging</h2><ul><li class="half_rhythm"><div><a href="https://medpics.ucsd.edu/index.cfm" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MedPics – Clinical, hematology, histology and pathology image and text database system</a><br />University of California San Diego, School of Medicine</div></li><li class="half_rhythm"><div><a href="https://medpix.nlm.nih.gov/home" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MedPix – Arrayed radiographic image and text database, including patient profiles</a>
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<br />Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH</div></li></ul></div><div id="resource.Monitoring_Systems"><h2 id="_resource_Monitoring_Systems_">Monitoring Systems</h2><ul><li class="half_rhythm"><div><a href="https://www.fda.gov/drugs/questions-and-answers-fdas-adverse-event-reporting-system-faers/fda-adverse-event-reporting-system-faers-public-dashboard" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">FAERS/FDA Adverse Event Reporting System – Postmarketing adverse drug event reporting</a>
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<br />Center for Drug Evaluation and Research, Food and Drug Administration</div></li><li class="half_rhythm"><div><a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MedWatch – FDA Postmarketing product safety reporting program</a><br />Center for Drug Evaluation and Research, Food and Drug Administration</div></li></ul></div><div id="resource.Registries_and_Research"><h2 id="_resource_Registries_and_Research_">Registries and Research</h2><ul><li class="half_rhythm"><div><a href="https://www.utsouthwestern.edu/labs/acute-liver/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ALF/Acute Liver Failure Study Group – Registry for all forms of liver failure</a><br />University of Texas Southwestern Medical Center at Dallas</div></li><li class="half_rhythm"><div><a href="https://www.clinicaltrials.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ClinicalTrials – Registry of federally and privately supported clinical research</a><br />National Library of Medicine, NIH</div></li><li class="half_rhythm"><div><a href="https://dilin.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">DILIN/Drug-Induced Liver Injury Network – Registry, analysis of cases of drug-induced liver injury</a>
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<br />National Institute of Diabetes and Digestive and Kidney Diseases; Duke Clinical Research Institute; Consortium of nine clinical centers</div></li><li class="half_rhythm"><div><a href="https://www.fda.gov/science-research/bioinformatics-tools/endocrine-disruptor-knowledge-base" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EDKB/Endocrine Disruptor Knowledge Base – For computational predictive toxicology models</a><br />National Center for Toxicological Research, Food and Drug Administration</div></li><li class="half_rhythm"><div><a href="https://www.fda.gov/science-research/bioinformatics-tools/liver-toxicity-knowledge-base-ltkb" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">LTKB/Liver Toxicity Knowledge Base </a>– Resources for understanding drug-induced liver injury</div></li><li class="half_rhythm"><div>
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||
<a href="https://www.fda.gov/science-research/liver-toxicity-knowledge-base-ltkb/ltkb-benchmark-dataset" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">LTKB/Liver Toxicity Knowledge Base Benchmark Dataset</a>
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</div></li><li class="half_rhythm"><div><a href="https://www.fda.gov/science-research/liver-toxicity-knowledge-base-ltkb/liver-toxicity-knowledge-base-publications" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">LTKB/Liver Toxicity Knowledge Base Publications</a><br />National Center for Toxicological Research, Food and Drug Administration</div></li><li class="half_rhythm"><div><a href="https://www.chop.edu/pages/pediatric-acute-liver-failure-study-group" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PALF/Pediatric Acute Liver Failure Study Group – Registry for all forms of pediatric liver failure</a><br />University of Pittsburgh</div></li></ul></div><div id="resource.Select_Review_Articles_Recent_4"><h2 id="_resource_Select_Review_Articles_Recent_4_">Select Review Articles [Recent 4 Years]</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="resource.REF.1">Hey-Hadavi J, Seekins D, Palmer M, Coffey D, Caminis J, Abdullaev S, Patwardhan M, et al. Overview of causality assessment for drug-induced liver injury (DILI) in clinical trials. <span><span class="ref-journal">Drug Saf. </span>2021 Mar 16;</span> Epub ahead of print. [<a href="/pmc/articles/PMC8184702/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8184702</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/33725335" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33725335</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="resource.REF.2">Devarbhavi H, Aithal G, Treeprasertsuk S, Takikawa H, Mao Y, Shasthry SM, Hamid S, Tan SS, et al. Asia Pacific Association of Study of Liver. Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines. <span><span class="ref-journal">Hepatol Int. </span>2021 Feb 27;</span> Epub ahead of print. [<a href="https://pubmed.ncbi.nlm.nih.gov/33641080" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33641080</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="resource.REF.3">Liu A, Walter M, Wright P, Bartosik A, Dolciami D, Elbasir A, Yang H, Bender A. Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure. <span><span class="ref-journal">Biol Direct. </span>2021;<span class="ref-vol">16</span>(1):6.</span> [<a href="/pmc/articles/PMC7814730/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7814730</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/33461600" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33461600</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="resource.REF.4">Takemura A, Ito K. <span><span class="ref-journal">Nihon Yakurigaku Zasshi. </span>2020;<span class="ref-vol">155</span>(6):401–5.</span> [The trends in predicting drug-induced liver injury] Japanese. [<a href="https://pubmed.ncbi.nlm.nih.gov/33132258" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33132258</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="resource.REF.5">Apel K, Pütz K, Tolkach Y, Canbay A, Drebber U. Drug-induced liver injury – Stellenwert der Pathologie. <span><span class="ref-journal">Pathologe. </span>2020;<span class="ref-vol">41</span>(5):457–70.</span> [Drug-induced liver injury–significance of pathology] German. [<a href="https://pubmed.ncbi.nlm.nih.gov/32813127" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32813127</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="resource.REF.6">Low EXS, Zheng Q, Chan E, Lim SG. Drug induced liver injury: East versus West – a systematic review and meta-analysis. <span><span class="ref-journal">Clin Mol Hepatol. </span>2020;<span class="ref-vol">26</span>(2):142–54.</span> [<a href="/pmc/articles/PMC7160354/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7160354</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31816676" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31816676</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="resource.REF.7">Gasmi B, Kleiner DE. Liver histology: diagnostic and prognostic features. <span><span class="ref-journal">Clin Liver Dis. </span>2020;<span class="ref-vol">24</span>(1):61–74.</span> [<a href="/pmc/articles/PMC6986808/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6986808</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31753251" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31753251</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="resource.REF.8">Watkins PB. Quantitative systems toxicology approaches to understand and predict drug-induced liver injury. <span><span class="ref-journal">Clin Liver Dis. </span>2020;<span class="ref-vol">24</span>(1):49–60.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/31753250" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31753250</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="resource.REF.9">Thakkar S, Li T, Liu Z, Wu L, Roberts R, Tong W. Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity. <span><span class="ref-journal">Drug Discov Today. </span>2020;<span class="ref-vol">25</span>(1):201–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/31669330" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31669330</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="resource.REF.10">Andrade RJ, Robles-Díaz M. Diagnostic and prognostic assessment of suspected drug-induced liver injury in clinical practice. <span><span class="ref-journal">Liver Int. </span>2020;<span class="ref-vol">40</span>(1):6–17.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/31578817" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31578817</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="resource.REF.11">Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, et al. Drug-induced liver injury. <span><span class="ref-journal">Nat Rev Dis Primers. </span>2019;<span class="ref-vol">5</span>(1):58.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/31439850" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31439850</span></a>]</div></dd><dt>12.</dt><dd><div class="bk_ref" id="resource.REF.12">Hoofnagle JH, Björnsson ES. Drug-induced liver injury – types and phenotypes. <span><span class="ref-journal">N Engl J Med. </span>2019;<span class="ref-vol">381</span>(3):264–73.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/31314970" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31314970</span></a>]</div></dd><dt>13.</dt><dd><div class="bk_ref" id="resource.REF.13">Uetrecht J. Mechanisms of idiosyncratic drug-induced liver injury. <span><span class="ref-journal">Adv Pharmacol. </span>2019;<span class="ref-vol">85</span>:133–63.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/31307585" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31307585</span></a>]</div></dd><dt>14.</dt><dd><div class="bk_ref" id="resource.REF.14">Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, et al. APASL ACLF Research Consortium (AARC) for APASL ACLF working Party. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. <span><span class="ref-journal">Hepatol Int. </span>2019;<span class="ref-vol">13</span>(4):353–90.</span> Erratum in: Hepatol Int 2019; 13(6): 826-8. [<a href="/pmc/articles/PMC6728300/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6728300</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31172417" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31172417</span></a>]</div></dd><dt>15.</dt><dd><div class="bk_ref" id="resource.REF.15">He S, Zhang C, Zhou P, Zhang X, Ye T, Wang R, Sun G, Sun X. Herb-induced liver injury: phylogenetic relationship, structure-toxicity relationship, and herb-ingredient network analysis. <span><span class="ref-journal">Int J Mol Sci. </span>2019;<span class="ref-vol">20</span>(15):3633.</span> [<a href="/pmc/articles/PMC6695972/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6695972</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31349548" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31349548</span></a>]</div></dd><dt>16.</dt><dd><div class="bk_ref" id="resource.REF.16">McGill MR, Jaeschke H. Biomarkers of drug-induced liver injury. <span><span class="ref-journal">Adv Pharmacol. </span>2019;<span class="ref-vol">85</span>:221–39.</span> [<a href="/pmc/articles/PMC7351790/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7351790</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31307588" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31307588</span></a>]</div></dd><dt>17.</dt><dd><div class="bk_ref" id="resource.REF.17">Real M, Barnhill MS, Higley C, Rosenberg J, Lewis JH. Drug-induced liver injury: highlights of the recent literature. <span><span class="ref-journal">Drug Saf. </span>2019;<span class="ref-vol">42</span>(3):365–87.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/30343418" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30343418</span></a>]</div></dd><dt>18.</dt><dd><div class="bk_ref" id="resource.REF.18">García-Cortés M, Ortega-Alonso A, Lucena MI, Andrade RJ., Spanish Group for the Study of Drug-Induced Liver Disease. (Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos GEHAM). Drug-induced liver injury: a safety review. <span><span class="ref-journal">Expert Opin Drug Saf. </span>2018;<span class="ref-vol">17</span>(8):795–804.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/30059261" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30059261</span></a>]</div></dd><dt>19.</dt><dd><div class="bk_ref" id="resource.REF.19">Roytman MM, Poerzgen P, Navarro V. Botanicals and Hepatotoxicity. <span><span class="ref-journal">Clin Pharmacol Ther. </span>2018;<span class="ref-vol">104</span>(3):458–69.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/29920648" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29920648</span></a>]</div></dd><dt>20.</dt><dd><div class="bk_ref" id="resource.REF.20">Ortega-Alonso A, Andrade RJ. Chronic liver injury induced by drugs and toxins. <span><span class="ref-journal">J Dig Dis. </span>2018;<span class="ref-vol">19</span>(9):514–21.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/29808546" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29808546</span></a>]</div></dd><dt>21.</dt><dd><div class="bk_ref" id="resource.REF.21">Kleiner DE. Recent advances in the histopathology of drug-induced liver injury. <span><span class="ref-journal">Surg Pathol Clin. </span>2018;<span class="ref-vol">11</span>(2):297–311.</span> [<a href="/pmc/articles/PMC5953206/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5953206</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29751876" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29751876</span></a>]</div></dd><dt>22.</dt><dd><div class="bk_ref" id="resource.REF.22">Thakkar S, Chen M, Fang H, Liu Z, Roberts R, Tong W. The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury. <span><span class="ref-journal">Expert Rev Gastroenterol Hepatol. </span>2018;<span class="ref-vol">12</span>(1):31–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/28931315" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28931315</span></a>]</div></dd><dt>23.</dt><dd><div class="bk_ref" id="resource.REF.23">Brown AC. Liver toxicity related to herbs and dietary supplements: Online table of case reports. Part 2 of 5 series. <span><span class="ref-journal">Food Chem Toxicol. </span>2017;<span class="ref-vol">107</span>:472–501.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/27402097" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27402097</span></a>]</div></dd><dt>24.</dt><dd><div class="bk_ref" id="resource.REF.24">Navarro VJ, Khan I, Björnsson E, Seeff LB, Serrano J, Hoofnagle JH. Liver injury from herbal and dietary supplements. <span><span class="ref-journal">Hepatology. </span>2017;<span class="ref-vol">65</span>(1):363–73.</span> [<a href="/pmc/articles/PMC5502701/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5502701</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27677775" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27677775</span></a>]</div></dd></dl></div><div id="resource.LiverTox_Promotional_Handout"><h2 id="_resource_LiverTox_Promotional_Handout_">LiverTox Promotional Handout</h2><ul><li class="half_rhythm"><div>Users of LiverTox are encouraged to reproduce the <a href="/books/NBK548776/bin/LiverToxBrochure.pdf">LiverTox Handout</a> for distribution at relevant professional/scientific meetings.</div></li></ul></div><div id="bk_toc_contnr"></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK548776/?report=reader">PubReader</a></li><li><a href="/books/NBK548776/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK548776" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK548776" style="display:none" title="Cite this Page"><div class="bk_tt">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. 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