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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="All Drug Records" href="/books/n/livertox/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" alt="Cover of LiverTox" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK548348_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK548348_dtls__"><div>Bethesda (MD): <a href="https://www.niddk.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Diabetes and Digestive and Kidney Diseases</a>; 2012-.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/livertox/">Drug Records</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/livertox/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/livertox/Repaglinide/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/livertox/Reslizumab/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK548348_"><span class="title" itemprop="name">Reserpine</span></h1><p class="small">Last Update: <span itemprop="dateModified">May 21, 2018</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="Reserpine.OVERVIEW"><h2 id="_Reserpine_OVERVIEW_">OVERVIEW</h2><div id="Reserpine.Introduction"><h3>Introduction</h3><p>Reserpine is an oral antihypertensive medication that acts through inhibitor of alpha-adrenergic transmission and was one of the first antihypertensive agents introduced into clinical practice. Despite widescale use for many years, reserpine has not been shown to cause clinically apparent liver injury.</p></div><div id="Reserpine.Background"><h3>Background</h3><p>Reserpine (re ser' peen) was one of the first antihypertensive agents developed for use in humans. It is an alkaloid extract of the Rauwolifia serpentine (thus its name) which is a climbing shrub found in India. Reserpine is thought to act by binding to adrenergic storage vesicles in neurons, inhibiting their capacity to concentrate and store norepinephrine and dopamine. The antihypertensive effect of reserpine correlates with the depletion of sympathetic amines in both the central nervous system and periphery. Reserpine is effective in lowering blood pressure and can be used alone or in combination with other antihypertensive medications. Reserpine was approved for use in the United States in 1955 but is currently rarely used, largely because of its central nervous system effects and the availability of many better tolerated and more potent antihypertensive medications. Reserpine continues to be available in generic forms as tablets of 0.1 and 0.25 mg. The typical maintenance dose in adults is 0.05 to 0.25 mg once daily. Side effects are common and include sedation, difficulty concentrating, fatigue, depression, dry mouth, headaches, dizziness, postural hypotension, male impotence and gastrointestinal upset.</p></div><div id="Reserpine.Hepatotoxicity"><h3>Hepatotoxicity</h3><p>Serum aminotransferase elevations during reserpine therapy are uncommon, but specific rates of such elevations in comparison to placebo treatment have not been reported. Despite many decades of use, reserpine has been implicated in few instances of clinically apparent acute liver injury, and none of them were particularly convincing. Published cases were marked by jaundice and abdominal pain arising a year after starting reserpine, but in combination with other known hepatotoxic agents (dihydrazine, phenobarbital, quinidine). The few cases that have been reported were self-limiting and resolved within a few months of stopping therapy. The last case of suspected reserpine associated liver injury was published more than 50 years ago.</p><p><a class="def" href="/books/n/livertox/glossary/def-item/glossary.likelihood-score/">Likelihood score</a>: E (unlikely cause of clinically apparent liver injury).</p></div><div id="Reserpine.Mechanism_of_Injury"><h3>Mechanism of Injury</h3><p>Reserpine is metabolized by the cytochrome P450 (CYP) system to a major degree but neither induces or inhibits CYP activity, which may account in part for its relative lack of hepatotoxicity.</p><p>Drug Class: <a href="/books/n/livertox/AntihypertensiveAgen/">Antihypertensive Agents</a></p></div></div><div id="Reserpine.PRODUCT_INFORMATION"><h2 id="_Reserpine_PRODUCT_INFORMATION_">PRODUCT INFORMATION</h2><div id="Reserpine.BPI" class="box"><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Reserpine – Generic</p><p>
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<b>DRUG CLASS</b>
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</p><p>Antihypertensive Agent</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=reserpine" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div></div><div id="Reserpine.CHEMICAL_FORMULA_AND_STRUCTURE"><h2 id="_Reserpine_CHEMICAL_FORMULA_AND_STRUCTURE_">CHEMICAL FORMULA AND STRUCTURE</h2><div id="Reserpine.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK548348/table/Reserpine.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Reserpine.T1_lrgtbl__"><table><thead><tr><th id="hd_h_Reserpine.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">DRUG</th><th id="hd_h_Reserpine.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">CAS REGISTRY NUMBER</th><th id="hd_h_Reserpine.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">MOLECULAR FORMULA</th><th id="hd_h_Reserpine.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">STRUCTURE</th></tr></thead><tbody><tr><td headers="hd_h_Reserpine.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">Reserpine</td><td headers="hd_h_Reserpine.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134971500" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">50-55-5</a>
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</td><td headers="hd_h_Reserpine.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">C33-H40-N2-O9</td><td headers="hd_h_Reserpine.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">
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<div class="graphic"><img src="/books/NBK548348/bin/Reserpine_Structure.jpg" alt="Reserpine Chemical Structure" /></div>
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</td></tr></tbody></table></div></div></div><div id="Reserpine.ANNOTATED_BIBLIOGRAPHY"><h2 id="_Reserpine_ANNOTATED_BIBLIOGRAPHY_">ANNOTATED BIBLIOGRAPHY</h2><p>References updated: 21 May 2018</p><ul class="first-line-outdent"><li><div class="bk_ref" id="Reserpine.R1">Zimmerman HJ. Drugs used in cardiovascular disease. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott, 1999, pp. 639-71.<div><i>(Expert review of hepatotoxicity published in 1999; reserpine rarely causes significant liver injury, only two case reports having been published despite its wide use).</i></div></div></li><li><div class="bk_ref" id="Reserpine.R2">De Marzio DH, Navarro VJ. Hepatotoxicity of cardiovascular and antidiabetic drugs: antihypertensives. In, Kaplowitz N, DeLeve LD, eds. Drug-induced liver disease. 3rd ed. Amsterdam: Elsevier, 2013, pp. 519-40.<div><i>(Review of hepatotoxicity of hypertensive agents; reserpine is not discussed).</i></div></div></li><li><div class="bk_ref" id="Reserpine.R3">Michel T, Hoffman BB. Therapy of myocardial ischemia and hypertension. In, Brunton LL, Lazo JS, Parker KL, eds. Goodman & Gilman’s the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill, 2011, pp. 745-88.<div><i>(Textbook of pharmacology and therapeutics; “reserpine was the first drug that was found to interfere with the function of the sympathetic nervous system in human beings, and its use began the modern era of effective pharmacotherapy of hypertension”).</i></div></div></li><li><div class="bk_ref" id="Reserpine.R4">Nagler A, Enat R. [Liver damage due to reserpine hypersensitivity]. Harefuah 1984; 107: 130-1. Hebrew. [<a href="https://pubmed.ncbi.nlm.nih.gov/6510817" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6510817</span></a>]<div><i>(52 year old woman developed jaundice 1 year after starting combination of dihydralazine and reserpine for hypertension [bilirubin 8 mg/dL, AST 480 U/L, Alk P 263 U/L], resolving within 1 month of stopping and recurring after 1 month of restarting both; may have been due to dihydralazine, but positive in vitro reactions occurred with reserpine alone).</i></div></div></li><li><div class="bk_ref" id="Reserpine.R5">Moeckel W. [On the clinical picture of jaundice with intrahepatic cholestasis caused by drugs]. Med Klin 1965; 60: 294-8. German. [<a href="https://pubmed.ncbi.nlm.nih.gov/14258124" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14258124</span></a>]<div><i>(Five cases of drug induced cholestatic hepatitis; case 3 was 66 year old man who developed jaundice after being on reserpine, phenobarbital and quinidine for one year [bilirubin 17.4 mg/dL, Alk P 2 times ULN, eosinophils 12%]; while phenobarbital and quinidine can also cause liver injury, the case was attributed to reserpine on the basis of in vitro stimulation tests).</i></div></div></li><li><div class="bk_ref" id="Reserpine.R6">Drugs for hypertension. Treat Guidel Med Lett 2009; 7: 1-10. [<a href="https://pubmed.ncbi.nlm.nih.gov/19107095" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19107095</span></a>]<div><i>(Brief overview of currently available drugs for hypertension with guidelines on their use and information on prices and toxicities: “Reserpine is an effective antihypertensive, but is seldom used now because in doses much higher than currently recommended, it can cause severe depression”). </i></div></div></li><li><div class="bk_ref" id="Reserpine.R7">Hernández N, Bessone F, Sánchez A, di Pace M, Brahm J, Zapata R, A Chirino R, et al. Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports. Ann Hepatol 2014; 13: 231-9. [<a href="https://pubmed.ncbi.nlm.nih.gov/24552865" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24552865</span></a>]<div><i> (Systematic review of literature of drug induced liver injury in Latin American countries published from 1996 to 2012 identified 176 cases; no cases were attributed to reserpine).</i></div></div></li><li><div class="bk_ref" id="Reserpine.R8">Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, et al.; United States Drug Induced Liver Injury Network. Features and outcomes of 899 patients with drug-induced liver injury: The DILIN Prospective Study. Gastroenterology 2015; 148: 1340-52.e7. [<a href="/pmc/articles/PMC4446235/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4446235</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25754159" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25754159</span></a>]<div><i>(Among 899 cases of drug induced liver injury enrolled in a US prospective study between 2004 and 2013, 39 [4%] were due to antihypertensive agents but none were believed to be due to reserpine).</i></div></div></li><li><div class="bk_ref" id="Reserpine.R9">Drugs for hypertension. Med Lett Drugs Ther 2017; 59 (1516): 41-8. [<a href="https://pubmed.ncbi.nlm.nih.gov/28263286" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28263286</span></a>]<div><i>(Concise overview of the currently available drugs for hypertension with guidelines on their use and information on prices and toxicities; reserpine is not discussed).</i></div></div></li></ul></div><div id="bk_toc_contnr"></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK548348/?report=reader">PubReader</a></li><li><a href="/books/NBK548348/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK548348" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK548348" style="display:none" title="Cite this Page"><div class="bk_tt">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. 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<a href="https://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&pubmedfilters=true&term=(reserpine/AE)+AND+Human%5BMH%5D+AND+(drug+induced+liver+injury+OR+jaundice/CI+OR+bile+duct+diseases/CI+OR+liver/DE+OR+liver+diseases/CI)+AND+(%221900/1/1%22%5BEDat%5D%3A%222999/12/31%22%5BEDat%5D)" ref="pagearea=document-links&targetsite=external&targetcat=link&targettype=uri">Recent References on Reserpine: from PubMed.gov</a>
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<a href="https://clinicaltrials.gov/ct2/results?term=Reserpine" ref="pagearea=document-links&targetsite=external&targetcat=link&targettype=uri">Trials on Reserpine: from ClinicalTrials.gov</a>
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</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pmc&DbFrom=books&Cmd=Link&LinkName=books_pmc_refs&IdsFromResult=4863542" ref="log$=recordlinks">PMC</a><div class="brieflinkpop offscreen_noflow">PubMed Central citations</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pcsubstance&DbFrom=books&Cmd=Link&LinkName=books_pcsubstance&IdsFromResult=4863542" ref="log$=recordlinks">PubChem Substance</a><div class="brieflinkpop offscreen_noflow">Related PubChem Substances</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pubmed&DbFrom=books&Cmd=Link&LinkName=books_pubmed_refs&IdsFromResult=4863542" ref="log$=recordlinks">PubMed</a><div class="brieflinkpop offscreen_noflow">Links to PubMed</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/14076165" ref="ordinalpos=1&linkpos=1&log$=relatedarticles&logdbfrom=pubmed">OBSERVATIONS ON THE ANTIHYPERTENSIVE AND SEDATIVE EFFECTS OF MEBUTAMATE, MEPROBAMATE AND RESERPINE.</a><span class="source">[Can Med Assoc J. 1963]</span><div class="brieflinkpop offscreen_noflow">OBSERVATIONS ON THE ANTIHYPERTENSIVE AND SEDATIVE EFFECTS OF MEBUTAMATE, MEPROBAMATE AND RESERPINE.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">MORIN Y, TURMEL L, GRANTHAM H, FORTIER J. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Can Med Assoc J. 1963 Nov 9; 89(19):980-2. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/2869634" ref="ordinalpos=1&linkpos=2&log$=relatedarticles&logdbfrom=pubmed">Modification of reserpine induced rigidity by dopaminergic and alpha-adrenergic drugs.</a><span class="source">[Acta Neurol Scand. 1985]</span><div class="brieflinkpop offscreen_noflow">Modification of reserpine induced rigidity by dopaminergic and alpha-adrenergic drugs.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Anderson RJ. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Acta Neurol Scand. 1985 Dec; 72(6):584-9. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/2564288" ref="ordinalpos=1&linkpos=3&log$=relatedarticles&logdbfrom=pubmed">The thermogenic actions of alpha 2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic alpha 2-adrenoceptor mechanism.</a><span class="source">[Br J Pharmacol. 1989]</span><div class="brieflinkpop offscreen_noflow">The thermogenic actions of alpha 2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic alpha 2-adrenoceptor mechanism.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Bill DJ, Hughes IE, Stephens RJ. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Br J Pharmacol. 1989 Jan; 96(1):133-43. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/14156239" ref="ordinalpos=1&linkpos=4&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [ACUTE ADRENERGIC INSUFFICIENCY].</a><span class="source">[Laval Med. 1964]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> [ACUTE ADRENERGIC INSUFFICIENCY].<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">DERY R. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Laval Med. 1964 May; 35:501-4. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/14076003" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> ADRENERGIC MECHANISMS IN THE TREATMENT OF ESSENTIAL HYPERTENSION.</a><span class="source">[Am J Cardiol. 1963]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> ADRENERGIC MECHANISMS IN THE TREATMENT OF ESSENTIAL HYPERTENSION.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">ABRAMS WB, MOE RA, BATES H, WALLEN M, ODZE M, CREWS A, POCELINKO R. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Am J Cardiol. 1963 Nov; 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