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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]" /><meta name="citation_title" content="Neomycin" /><meta name="citation_publisher" content="National Institute of Diabetes and Digestive and Kidney Diseases" /><meta name="citation_date" content="2019/04/12" /><meta name="citation_pmid" content="31643210" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK547874/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Neomycin" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Diabetes and Digestive and Kidney Diseases" /><meta name="DC.Date" content="2019/04/12" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK547874/" /><meta name="description" content="Neomycin is a broad spectrum aminoglycoside antibiotic whose current use is limited to oral and topical administration. Neomycin has minimal oral absorption and its use has not been linked to instances of acute liver injury." /><meta name="og:title" content="Neomycin" /><meta name="og:type" content="book" /><meta name="og:description" content="Neomycin is a broad spectrum aminoglycoside antibiotic whose current use is limited to oral and topical administration. Neomycin has minimal oral absorption and its use has not been linked to instances of acute liver injury." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK547874/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/livertox/Neomycin/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK547874/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="All Drug Records" href="/books/n/livertox/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" alt="Cover of LiverTox" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK547874_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK547874_dtls__"><div>Bethesda (MD): <a href="https://www.niddk.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Diabetes and Digestive and Kidney Diseases</a>; 2012-.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/livertox/">Drug Records</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/livertox/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/livertox/Nelfinavir/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/livertox/Neratinib/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK547874_"><span class="title" itemprop="name">Neomycin</span></h1><p class="small">Last Update: <span itemprop="dateModified">April 12, 2019</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="Neomycin.OVERVIEW"><h2 id="_Neomycin_OVERVIEW_">OVERVIEW</h2><div id="Neomycin.Introduction"><h3>Introduction</h3><p>Neomycin is a broad spectrum aminoglycoside antibiotic whose current use is limited to oral and topical administration. Neomycin has minimal oral absorption and its use has not been linked to instances of acute liver injury.</p></div><div id="Neomycin.Background"><h3>Background</h3><p>Neomycin (nee" oh mye' sin) is an aminoglycoside with a broad spectrum of activity against both gram positive and gram negative organisms. Like other aminoglycosides, neomycin is thought to act by binding to bacterial ribosomes and inhibiting protein synthesis. Neomycin has activity against many aerobic gram negative and gram positive bacteria, including the major E. coli species resident in the colon as well as the enteropathogenic forms of E. coli known to cause traveler’s diarrhea. Like other aminoglycosides, neomycin is poorly absorbed orally. The lack of absorption from the gastrointestinal tract is the basis of the main use of neomycin, as an oral agent to suppress intestinal bacterial flora. Oral neomycin is indicated for treatment of infectious diarrhea, for suppression of intestinal bacterial flora in patients undergoing colorectal surgery, and as a means of decreasing colonic bacteria and production of ammonia in hepatic encephalopathy. Topical neomycin is used for burns, wounds and ulcerations and as otic suspensions for external otitis. Neomycin is available in multiple generic forms including oral tablets of 500 mg. The typical adult dose of neomycin is 1 to 3 grams daily in four divided doses. Long term therapy should be avoided because of the possibility of some systemic absorption and the high rate of oto- and nephrotoxicity associated with neomycin use. Other adverse events include nausea, diarrhea, and <i>Clostridium difficile</i> related colitis.</p></div><div id="Neomycin.Hepatotoxicity"><h3>Hepatotoxicity</h3><p>Oral and topical therapy with neomycin has not been linked serum alkaline phosphatase or aminotransferase elevations, and no convincing cases of symptomatic or icteric hepatotoxicity due to oral neomycin have been published. The poor absorption of neomycin makes it unlikely that systemic levels of the drug that might cause liver injury could be achieved. Furthermore, the ototoxicity of absorbed neomycin is likely to supervene before liver toxicity would occur.</p><p>References to the safety and potential hepatotoxicity of neomycin are provided in the Overview section on the Aminoglycosides.</p><p>Drug Class: <a href="/books/n/livertox/Aminoglycosides/">Aminoglycosides</a></p><p>Other Drugs in the Class: <a href="/books/n/livertox/Amikacin/">Amikacin</a>, <a href="/books/n/livertox/Gentamicin/">Gentamicin</a>, <a href="/books/n/livertox/Plazomicin/">Plazomicin</a>, <a href="/books/n/livertox/Streptomycin/">Streptomycin</a>,
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<a href="/books/n/livertox/Tobramycin/">Tobramycin</a></p></div></div><div id="Neomycin.PRODUCT_INFORMATION"><h2 id="_Neomycin_PRODUCT_INFORMATION_">PRODUCT INFORMATION</h2><div id="Neomycin.BPI" class="box"><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Neomycin – Generic</p><p>
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<b>DRUG CLASS</b>
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</p><p>Aminoglycosides</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Neomycin" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div></div><div id="Neomycin.CHEMICAL_FORMULA_AND_STRUCTURE"><h2 id="_Neomycin_CHEMICAL_FORMULA_AND_STRUCTURE_">CHEMICAL FORMULA AND STRUCTURE</h2><div id="Neomycin.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK547874/table/Neomycin.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Neomycin.T1_lrgtbl__"><table><thead><tr><th id="hd_h_Neomycin.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">DRUG</th><th id="hd_h_Neomycin.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">CAS REGISTRY NO.</th><th id="hd_h_Neomycin.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">MOLECULAR FORMULA</th><th id="hd_h_Neomycin.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">STRUCTURE</th></tr></thead><tbody><tr><td headers="hd_h_Neomycin.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">Neomycin</td><td headers="hd_h_Neomycin.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134980501" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">1404-04-2</a>
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</td><td headers="hd_h_Neomycin.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">Unspecified</td><td headers="hd_h_Neomycin.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">
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<div class="graphic"><img src="/books/NBK547874/bin/Neomycin_structure.jpg" alt="Neomycin chemical structure" /></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK547874/?report=reader">PubReader</a></li><li><a href="/books/NBK547874/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK547874" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK547874" style="display:none" title="Cite this Page"><div class="bk_tt">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. 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<a href="https://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&pubmedfilters=true&term=neomycin/AE+AND+Human%5BMH%5D+AND+(%20drug-induced+liver+injury+OR+jaundice/CI+OR+bile+duct+diseases/CI+OR+liver/DE+OR+liver+diseases/CI)+AND+(%221900/1/1%22%5BEDat%5D%3A%222999/12/31%22%5BEDat%5D)" ref="pagearea=document-links&targetsite=external&targetcat=link&targettype=uri">Recent References on Neomycin: from PubMed.gov</a>
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Epub 2016 Oct 29.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/33456155" ref="ordinalpos=1&linkpos=2&log$=relatedarticles&logdbfrom=pubmed">Systemic contact dermatitis following oral neomycin therapy.</a><span class="source">[Proc (Bayl Univ Med Cent). 2020]</span><div class="brieflinkpop offscreen_noflow">Systemic contact dermatitis following oral neomycin therapy.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Carnicle JM, Tran TV, McKissack SS. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Proc (Bayl Univ Med Cent). 2020 Aug 24; 34(1):89-90. Epub 2020 Aug 24.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/11039868" ref="ordinalpos=1&linkpos=3&log$=relatedarticles&logdbfrom=pubmed">Topical aminoglycoside ototoxicity: attempting to protect the cochlea.</a><span class="source">[Acta Otolaryngol. 2000]</span><div class="brieflinkpop offscreen_noflow">Topical aminoglycoside ototoxicity: attempting to protect the cochlea.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Conlon BJ, Smith DW. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Acta Otolaryngol. 2000 Aug; 120(5):596-9. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/35636122" ref="ordinalpos=1&linkpos=4&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Targeted modifications of neomycin and paromomycin: Towards resistance-free antibiotics?</a><span class="source">[Bioorg Chem. 2022]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Targeted modifications of neomycin and paromomycin: Towards resistance-free antibiotics?<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Obszynski J, Loidon H, Blanc A, Weibel JM, Pale P. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Bioorg Chem. 2022 Sep; 126:105824. Epub 2022 May 12.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/31643858" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Plazomicin.</a><span class="source">[LiverTox: Clinical and Researc...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Plazomicin.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012</em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed_reviews&uid=31643210" ref="ordinalpos=1&log$=relatedreviews_seeall&logdbfrom=pubmed">See reviews...</a><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=31643210" ref="ordinalpos=1&log$=relatedarticles_seeall&logdbfrom=pubmed">See all...</a></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Recent Activity</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="Shutter"></a></div><div class="portlet_content"><div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" id="HTDisplay" class=""><div class="action"><a href="javascript:historyDisplayState('ClearHT')">Clear</a><a href="javascript:historyDisplayState('HTOff')" class="HTOn">Turn Off</a><a href="javascript:historyDisplayState('HTOn')" class="HTOff">Turn On</a></div><ul id="activity"><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c8e099f4a390645e313afe">Nelfinavir - LiverTox</a><div class="ralinkpop offscreen_noflow">Nelfinavir - LiverTox<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c8e099b15b832ebc0fa3e9">Neomycin - LiverTox</a><div class="ralinkpop offscreen_noflow">Neomycin - LiverTox<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c8e098ab82281a803c415a">Nelarabine - LiverTox</a><div class="ralinkpop offscreen_noflow">Nelarabine - LiverTox<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c8e097ab82281a803c3dad">Nefazodone - LiverTox</a><div class="ralinkpop offscreen_noflow">Nefazodone - LiverTox<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67c8e096a68b6b5afc74268c">Necitumumab - LiverTox</a><div class="ralinkpop offscreen_noflow">Necitumumab - LiverTox<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li></ul><p class="HTOn">Your browsing activity is empty.</p><p class="HTOff">Activity recording is turned off.</p><p id="turnOn" class="HTOff"><a href="javascript:historyDisplayState('HTOn')">Turn recording back on</a></p><a class="seemore" href="/sites/myncbi/recentactivity">See more...</a></div></div></div>
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