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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="All Drug Records" href="/books/n/livertox/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" alt="Cover of LiverTox" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK548721_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK548721_dtls__"><div>Bethesda (MD): <a href="https://www.niddk.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Diabetes and Digestive and Kidney Diseases</a>; 2012-.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/livertox/">Drug Records</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/livertox/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/livertox/Mepolizumab/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/livertox/Mercaptopurine/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK548721_"><span class="title" itemprop="name">Meprobamate</span></h1><p class="small">Last Update: <span itemprop="dateModified">January 21, 2020</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="Meprobamate.OVERVIEW"><h2 id="_Meprobamate_OVERVIEW_">OVERVIEW</h2><div id="Meprobamate.Introduction"><h3>Introduction</h3><p>Meprobamate is a sedative used for anxiety and insomnia first made available in the 1950s when it became very popular, but which is now rarely used. Meprobamate therapy was not associated with liver enzyme elevations and has not been linked to instances of clinically apparent liver injury.</p></div><div id="Meprobamate.Background"><h3>Background</h3><p>Meprobamate (me" proe bam' ate) is a bis-carbamate ester which was found to have antianxiety activity and was introduced into medical use in the 1950s. Meprobamate rapidly became one of the most widely used psychotropic agents, being considered a “tranquillizer”. Commonly known by its brand name Miltown, it was approved for use in anxiety, but was widely used as a sedative and for insomnia. The sedative effects of meprobamate resemble those of the benzodiazepines, and it is known to bind to the GABA-A receptor. However, the precise mechanism of action of meprobamate is unclear. Meprobamate also has major abuse potential and many cases of dependency, habituation and overdose have been described. Withdrawal can lead to hallucinations and seizures. Meprobamate was approved for use in generalized anxiety disorders in the United States in 1955, but it is currently rarely used and is classified as a Schedule IV controlled substance because of its potential for abuse and dependency. Nevertheless, meprobamate remains available in several generic forms as 200 and 400 mg tablets. In addition, the muscle relaxant carisoprodol is a prodrug of meprobamate and is clinically available, although now it is also classified as a Schedule IV controlled substance [January 2012]. The recommended dosage of meprobamate is 1200 to 1600 mg daily in three or four divided doses. Side effects may include diarrhea, nausea, flatulence, drowsiness, ataxia, dizziness, headache, weakness, nervousness, euphoria, overstimulation and physical dependence. Uncommon but potentially severe adverse reactions include hypersensivity reactions including Stevens Johnson syndrome, embryo-fetal toxicity, addiction and dependence, stupor, coma and death from overdose.</p></div><div id="Meprobamate.Hepatotoxicity"><h3>Hepatotoxicity</h3><p>Rates of serum enzyme elevations during meprobamate therapy have not been reported. While instances of clinically apparent liver injury due to meprobamate have been mentioned in review articles, no cases with specific information on clinical features have appeared in the published literature. Thus, meprobamate may be capable of causing clinically apparent liver injury, but it must be rare. Meprobamate is metabolized in the liver via the cytochrome P450 system and has major potential for drug-drug interactions. Meprobamate can exacerbate symptoms of porphyria. Serious allergic reactions to meprobamate have been reported including Stevens Johnson syndrome. In cases of meprobamate overdose, the cause of death has been respiratory suppression and not liver failure, although liver histology was not well defined.</p><p><a class="def" href="/books/n/livertox/glossary/def-item/glossary.likelihood-score/">Likelihood score</a>: E* (unproven but suspected cause of liver injury).</p><p>Drug Class: <a href="/books/n/livertox/Sedatives_Hypnotics/">Sedatives and Hypnotics</a>, Miscellaneous</p></div></div><div id="Meprobamate.PRODUCT_INFORMATION"><h2 id="_Meprobamate_PRODUCT_INFORMATION_">PRODUCT INFORMATION</h2><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Meprobamate – Generic</p><p>
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<b>DRUG CLASS</b>
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</p><p>Sedatives and Hypnotics</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Meprobamate" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div><div id="Meprobamate.CHEMICAL_FORMULA_AND_STRUCTU"><h2 id="_Meprobamate_CHEMICAL_FORMULA_AND_STRUCTU_">CHEMICAL FORMULA AND STRUCTURE</h2><div id="Meprobamate.Tc" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK548721/table/Meprobamate.Tc/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Meprobamate.Tc_lrgtbl__"><table><tbody><tr><th id="hd_b_Meprobamate.Tc_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DRUG</th><th id="hd_b_Meprobamate.Tc_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CAS REGISTRY NUMBER</th><th id="hd_b_Meprobamate.Tc_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MOLECULAR FORMULA</th><th id="hd_b_Meprobamate.Tc_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">STRUCTURE</th></tr><tr><td headers="hd_b_Meprobamate.Tc_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meprobamate</td><td headers="hd_b_Meprobamate.Tc_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134971019" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">57-53-4</a>
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</td><td headers="hd_b_Meprobamate.Tc_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">C9-H18-N2-O4</td><td headers="hd_b_Meprobamate.Tc_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134971019" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134971019" alt="image 134971019 in the ncbi pubchem database" /></a>
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</td></tr></tbody></table></div></div></div><div id="Meprobamate.ANNOTATED_BIBLIOGRAPHY"><h2 id="_Meprobamate_ANNOTATED_BIBLIOGRAPHY_">ANNOTATED BIBLIOGRAPHY</h2><p>References updated: 21 January 2020</p><ul class="first-line-outdent"><li><div class="bk_ref" id="Meprobamate.REF.zimmerman.1999">Zimmerman HJ. Psychotropic and anticonvulsant agents. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott, 1999, pp. 483-516.<div><i>(Expert review of hepatotoxicity published in 1999; mentions that there have been three reported instances of liver injury attributed to meprobamate, but clinical features are not specifically discussed).</i></div></div></li><li><div class="bk_ref" id="Meprobamate.REF.kanel.2007">Kanel GC. Histopathology of drug-induced liver disease. In, Kaplowitz N, DeLeve LD, eds. Drug-induced liver disease. 2nd ed. New York: Informa Healthcare USA, 2007, p. 284.<div><i>(Meprobamate is listed as causing cholestasis with inflammation, but is not specifically discussed).</i></div></div></li><li><div class="bk_ref" id="Meprobamate.REF.mihic.2018">Mihic SJ, Mayfield J, Harris RA. Hypnotics and sedatives. In, Brunton LL, Chabner BA Hillal-Dandan R, Knollman BC, eds. Goodman & Gilman's the pharmacological basis of therapeutics. 13th ed. New York: McGraw-Hill, 2018, pp. 339-54.<div><i>(Textbook of pharmacology and therapeutics).</i></div></div></li><li><div class="bk_ref" id="Meprobamate.REF.selling.1955.1594">Selling LS. Clinical study of a new tranquilizing drug; use of miltown(2-methyl-2-n-propyl-1,3-propanediol dicarbamate). <span><span class="ref-journal">J Am Med Assoc. </span>1955;<span class="ref-vol">157</span>:1594–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14367012" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14367012</span></a>]<div>
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<i>(Among 187 patients with anxiety treated with meprobamate in a private practice, 64 recovered, 88 were improved, 35 were not improved and 3 patients developed allergic reactions; states that meprobamate "is not habit forming", but does not mention liver complications).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.friedman.1956.628">Friedman HT, Marmelzat WL. Adverse reactions to meprobamate. <span><span class="ref-journal">J Am Med Assoc. </span>1956;<span class="ref-vol">162</span>:628–30.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/13366645" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 13366645</span></a>]<div>
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<i>(Description of 7 cases of severe adverse events due to meprobamate, including rash [n=5], ocular palsy and severe diarrhea; no mention of liver injury).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.ewing.1957.76">Ewing JA, Fullilove RE. Addiction to meprobamate. <span><span class="ref-journal">N Engl J Med. </span>1957;<span class="ref-vol">257</span>:76–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/13452049" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 13452049</span></a>]<div>
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<i>(32 year old man taking 4 to 8 g of meprobamate daily developed headaches, muscle twitching, anxiety and somatic complaints during withdrawal).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.haizlip.1958.1181">Haizlip TM, Ewing JA. Meprobamate habituation: a controlled clinical study. <span><span class="ref-journal">N Engl J Med. </span>1958;<span class="ref-vol">258</span>:1181–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/13552940" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 13552940</span></a>]<div>
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<i>(75 residents of a State mental hospital were given meprobamate [3.2 and 6.4 g daily] or placebo for 40 days and then "surreptitiously" switched to placebo; withdrawal symptoms included insomnia, anxiety, tremors, nausea, hallucinations, acute psychosis and convulsions; no hepatic complications mentioned).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.cowger.1965.88">Cowger ML, Labbe RF. Contraindications of biological-oxidation inhibitors in the treatment of porphyria. <span><span class="ref-journal">Lancet. </span>1965;<span class="ref-vol">1</span>(7376):88–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14234213" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14234213</span></a>]<div>
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<i>(Mentions that clinical relapses of acute intermittent porphyria have occurred with drugs other than barbiturates, including chlordiazepoxide and meprobamate).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.ayd.1964.82">Ayd FJ Jr. Meprobamate: A decade of experience. <span><span class="ref-journal">Psychosomatics. </span>1964;<span class="ref-vol">5</span>:82–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14130886" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14130886</span></a>]<div>
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<i>(Review of the safety and efficacy of meprobamate after a decade of its wide scale clinical use; states "that meprobamate is free from hepatotoxicity is incontrovertible").</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.maddock.1967.999">Maddock RK Jr, Bloomer HA. Meprobamate overdosage. Evaluation of its severity and methods of treatment. <span><span class="ref-journal">JAMA. </span>1967;<span class="ref-vol">201</span>:999–1003.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/6072491" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6072491</span></a>]<div>
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<i>(10 patients with meprobamate overdose [1.6 to 30 g], ages 16 to 48 years, 7 women, 8 in coma, 1 died; plasma levels correlated with coma state and there was rapid renal clearance; no mention of liver injury).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.schwartz.1976.1177">Schwartz HS. Acute meprobamate poisoning with gastrotomy and removal of a drug-containing mass. <span><span class="ref-journal">N Engl J Med. </span>1976;<span class="ref-vol">295</span>:1177–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/980021" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 980021</span></a>]<div>
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<i>(56 year old woman developed coma and respiratory failure after overdose of 36 g of meprobamate, with persistent high levels in serum, gastroscopy demonstrating a mass of undigested meprobamate tablets in the stomach, ultimately requiring surgical removal; no mention of liver injury).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.crome.1977.698">Crome P, Higgenbottom T, Elliott JA. Severe meprobamate poisoning: successful treatment with haemoperfusion. <span><span class="ref-journal">Postgrad Med J. </span>1977;<span class="ref-vol">53</span>:698–9.</span> [<a href="/pmc/articles/PMC2496842/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2496842</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/593997" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 593997</span></a>]<div>
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<i>(56 year old woman with meprobamate overdose developed coma and respiratory depression, improved by hemoperfusion with charcoal column; no mention of liver injury).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.kintz.1988.139">Kintz P, Tracqui A, Mangin P, Lugnier AA. Fatal meprobamate self-poisoning. <span><span class="ref-journal">Am J Forensic Med Pathol. </span>1988;<span class="ref-vol">9</span>:139–40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/3381792" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3381792</span></a>]<div>
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<i>(35 year old man found dead with lethal levels of meprobamate in blood; no description of liver histology).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.littrell.1993.133">Littrell RA, Sage T, Miller W. Meprobamate dependence secondary to carisoprodol (Soma) use. <span><span class="ref-journal">Am J Drug Alcohol Abuse. </span>1993;<span class="ref-vol">19</span>:133–4.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8438828" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8438828</span></a>]<div>
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<i>(37 year old woman was found to have meprobamate on urine screening after a motor vehicle accident, but denied taking meprobamate, but did admit to use of carisoprodol which she was later found to regularly abuse).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.bailey.2002.396">Bailey DN, Briggs JR. Carisoprodol: an unrecognized drug of abuse. <span><span class="ref-journal">Am J Clin Pathol. </span>2002;<span class="ref-vol">117</span>:396–400.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11888078" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11888078</span></a>]<div>
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<i>(Over a 6 month period, 19 patients were found to have carisoprodol in urine on comprehensive drug screens, 12 with decrease in level of consciousness; liver injury not mentioned).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.buire.2009.126">Buire AC, Vitry F, Hoizey G, Lamiable D, Trenque T. Overdose of meprobamate: plasma concentration and Glasgow Coma Scale. <span><span class="ref-journal">Br J Clin Pharmacol. </span>2009;<span class="ref-vol">68</span>:126–7.</span> [<a href="/pmc/articles/PMC2732949/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2732949</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19660012" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19660012</span></a>]<div>
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<i>(Among 59 cases of meprobamate overdose, plasma levels correlated roughly with degree of coma; only one patient died).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.chalasani.2008.1924">Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J., Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. <span><span class="ref-journal">Gastroenterology. </span>2008;<span class="ref-vol">135</span>:1924–34.</span> [<a href="/pmc/articles/PMC3654244/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3654244</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18955056" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18955056</span></a>]<div>
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<i>(Among 300 cases of drug induced liver disease in the US collected from 2004 to 2008, none were attributed to meprobamate).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.fathallah.2011.404">Fathallah N, Zamy M, Slim R, Fain O, Hmouda H, Bouraoui K, Ben Salem C, Biour M. Acute pancreatitis in the course of meprobamate poisoning. <span><span class="ref-journal">JOP. </span>2011;<span class="ref-vol">12</span>:404–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21737904" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21737904</span></a>]<div>
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<i>(43 year old woman took an overdose of meprobamate [60 g] and was admitted in stupor and found to have pancreatitis [bilirubin 1.0 mg/dL, ALT 65 U/L, Alk P 115 U/L, lipase 21.3 times ULN], resolving with temporary ventilator support and hydration).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.herzberg.2011.415">Herzberg D. Blockbusters and controlled substances: Miltown, Quaalude, and consumer demand for drugs in postwar America. <span><span class="ref-journal">Stud Hist Philos Biol Biomed Sci. </span>2011;<span class="ref-vol">42</span>:415–26.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/22035715" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22035715</span></a>]<div>
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<i>(History of discovery, approval, marketing and subsequent wide scale use and abuse of meprobamate).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.reeves.2012.619">Reeves RR, Burke RS, Kose S. Carisoprodol: update on abuse potential and legal status. <span><span class="ref-journal">South Med J. </span>2012;<span class="ref-vol">105</span>:619–23.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/23128807" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23128807</span></a>]<div>
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<i>(Review of the clinical features and frequency of carisoprodol abuse which increased between 2001 and 2008 and decreased with the introduction of restrictions on its sale; carisoprodol was classified as a schedule IV controlled substance in the US starting in January 2012).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.hern_ndez.2014.231">Hernández N, Bessone F, Sánchez A, di Pace M, Brahm J, Zapata R, A, Chirino R, et al. Profile of idiosyncratic drug induced liver injury in Latin America: an analysis of published reports. <span><span class="ref-journal">Ann Hepatol. </span>2014;<span class="ref-vol">13</span>:231–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24552865" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24552865</span></a>]<div>
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<i>(Among 176 reports of drug induced liver injury from Latin America published between 1996 and 2012, none were attributed to meprobamate).</i>
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</div></div></li><li><div class="bk_ref" id="Meprobamate.REF.chalasani.2015.1340">Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, et al. United States Drug Induced Liver Injury Network. Features and outcomes of 899 patients with drug-induced liver injury: The DILIN Prospective Study. <span><span class="ref-journal">Gastroenterology. </span>2015;<span class="ref-vol">148</span>:1340–52.e7.</span> [<a href="/pmc/articles/PMC4446235/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4446235</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25754159" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25754159</span></a>]<div>
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<i>(Among 899 cases of drug induced liver injury enrolled in a US prospective study between 2004 and 2013, none were attributed to sedatives, meprobamate or carisoprodol).</i>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK548721/?report=reader">PubReader</a></li><li><a href="/books/NBK548721/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK548721" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK548721" style="display:none" title="Cite this Page"><div class="bk_tt">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Meprobamate. [Updated 2020 Jan 21].<span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK548721/pdf/Bookshelf_NBK548721.pdf">PDF version of this page</a> (99K)</li><li><a href="#" class="toggle-glossary-link" title="Enable/disable links to the glossary">Disable Glossary Links</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>New and Updated</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22LiverTox%22+AND+pmcbook&sort=date&size=200" ref="pagearea=source-links&targetsite=external&targetcat=link&targettype=uri">In PubMed</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Bulk Download</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="https://ftp.ncbi.nlm.nih.gov/pub/litarch/29/31/" ref="pagearea=source-links&targetsite=external&targetcat=link&targettype=uri">Bulk download LiverTox data from FTP</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Overviews</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/n/livertox/intro/">Introduction</a></li><li><a href="/books/n/livertox/ClinicalCourse/">Clinical Course</a></li><li><a href="/books/n/livertox/ClinicalOutcome/">Clinical Outcomes</a></li><li><a href="/books/n/livertox/ImmuneFeatures/">Immune Features</a></li><li><a href="/books/n/livertox/Phenotypes_intro/">Phenotypes</a></li><li><a href="/books/n/livertox/Causality/">Causality</a></li><li><a href="/books/n/livertox/DrugCategory/">Likelihood Scale</a></li><li><a href="/books/n/livertox/Severity/">Severity Grading</a></li><li><a href="/books/n/livertox/CaseReport/">Writing a Case Report</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Support Links</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/n/livertox/">LiverTox Homepage</a></li><li><a href="/books/n/livertox/masterlistintro/">Master List of LiverTox Drugs [with Metadata]</a></li><li><a href="/books/n/livertox/drugliverinjury/">LiverTox Drugs by Drug Class</a></li><li><a href="/books/n/livertox/aboutus/">About LiverTox</a></li><li><a href="/books/n/livertox/editorsandreviewers/">Editors and Review Committee</a></li><li><a href="/books/n/livertox/alert/">Meetings and News</a></li><li><a href="/books/n/livertox/abbreviation/">Abbreviations Used</a></li><li><a href="/books/n/livertox/glossary/">Glossary</a></li><li><a href="/books/n/livertox/resource/">Information Resources</a></li><li><a href="/books/n/livertox/disclaimer/">User/Medical Advice Disclaimer</a></li><li><a href="/books/n/livertox/Contactus/">Contact Us</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>OTHER REFERENCE LINKS</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li>
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<a href="https://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&pubmedfilters=true&term=(Meprobamate/AE)+AND+Human%5BMH%5D+AND+(drug+induced+liver+injury+OR+jaundice/CI+OR+bile+duct+diseases/CI+OR+liver/DE+OR+liver+diseases/CI)+AND+(%221900/1/1%22%5BEDat%5D:%222999/12/31%22%5BEDat%5D)" ref="pagearea=document-links&targetsite=external&targetcat=link&targettype=uri">Recent References on Meprobamate: from PubMed.gov</a>
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<a href="https://clinicaltrials.gov/ct2/results?term=Meprobamate" ref="pagearea=document-links&targetsite=external&targetcat=link&targettype=uri">Trials on Meprobamate: from ClinicalTrials.gov</a>
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</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pmc&DbFrom=books&Cmd=Link&LinkName=books_pmc_refs&IdsFromResult=4864304" ref="log$=recordlinks">PMC</a><div class="brieflinkpop offscreen_noflow">PubMed Central citations</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pcsubstance&DbFrom=books&Cmd=Link&LinkName=books_pcsubstance&IdsFromResult=4864304" ref="log$=recordlinks">PubChem Substance</a><div class="brieflinkpop offscreen_noflow">Related PubChem Substances</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pubmed&DbFrom=books&Cmd=Link&LinkName=books_pubmed_refs&IdsFromResult=4864304" ref="log$=recordlinks">PubMed</a><div class="brieflinkpop offscreen_noflow">Links to PubMed</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/14076165" ref="ordinalpos=1&linkpos=1&log$=relatedarticles&logdbfrom=pubmed">OBSERVATIONS ON THE ANTIHYPERTENSIVE AND SEDATIVE EFFECTS OF MEBUTAMATE, MEPROBAMATE AND RESERPINE.</a><span class="source">[Can Med Assoc J. 1963]</span><div class="brieflinkpop offscreen_noflow">OBSERVATIONS ON THE ANTIHYPERTENSIVE AND SEDATIVE EFFECTS OF MEBUTAMATE, MEPROBAMATE AND RESERPINE.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">MORIN Y, TURMEL L, GRANTHAM H, FORTIER J. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Can Med Assoc J. 1963 Nov 9; 89(19):980-2. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/14087491" ref="ordinalpos=1&linkpos=2&log$=relatedarticles&logdbfrom=pubmed">[MEPROBAMATE IN OBSTETRICS].</a><span class="source">[Dia Med. 1963]</span><div class="brieflinkpop offscreen_noflow">[MEPROBAMATE IN OBSTETRICS].<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">BALLAS R. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Dia Med. 1963 Sep 2; 35:1370-1. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/14141975" ref="ordinalpos=1&linkpos=3&log$=relatedarticles&logdbfrom=pubmed">[ANXIETY AND INSOMNIA. APROPOS OF A NEW MEDICAMENTOUS COMBINATION: LE FH 040-3].</a><span class="source">[Lyon Med. 1964]</span><div class="brieflinkpop offscreen_noflow">[ANXIETY AND INSOMNIA. APROPOS OF A NEW MEDICAMENTOUS COMBINATION: LE FH 040-3].<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">PONT M, CHAPUY A, VEDRINNE J. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Lyon Med. 1964 Feb 23; 211:465-9. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/31644179" ref="ordinalpos=1&linkpos=4&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Hops.</a><span class="source">[LiverTox: Clinical and Researc...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Hops.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/31643352" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Passionflower.</a><span class="source">[LiverTox: Clinical and Researc...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Passionflower.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012</em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed_reviews&uid=31644030" ref="ordinalpos=1&log$=relatedreviews_seeall&logdbfrom=pubmed">See reviews...</a><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=31644030" ref="ordinalpos=1&log$=relatedarticles_seeall&logdbfrom=pubmed">See all...</a></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Recent Activity</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="Shutter"></a></div><div class="portlet_content"><div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" id="HTDisplay" class=""><div class="action"><a href="javascript:historyDisplayState('ClearHT')">Clear</a><a href="javascript:historyDisplayState('HTOff')" class="HTOn">Turn Off</a><a href="javascript:historyDisplayState('HTOn')" class="HTOff">Turn On</a></div><ul id="activity"><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c8e052ab82281a803adb86">Meprobamate - LiverTox</a><div class="ralinkpop offscreen_noflow">Meprobamate - LiverTox<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67c8e050f4a390645e2fe1b5">Mepolizumab - LiverTox</a><div class="ralinkpop offscreen_noflow">Mepolizumab - LiverTox<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67c8e04fab82281a803ad149">Meperidine - LiverTox</a><div class="ralinkpop offscreen_noflow">Meperidine - LiverTox<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67c8e04ea68b6b5afc72c56b">Mepenzolate - 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