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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]" /><meta name="citation_title" content="Lecanemab" /><meta name="citation_publisher" content="National Institute of Diabetes and Digestive and Kidney Diseases" /><meta name="citation_date" content="2023/02/10" /><meta name="citation_pmid" content="36862819" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK589468/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Lecanemab" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Diabetes and Digestive and Kidney Diseases" /><meta name="DC.Date" content="2023/02/10" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK589468/" /><meta name="description" content="Lecanemab is a human monoclonal antibody to amyloid beta which has been approved for use in Alzheimer disease. Lecanemab has not been associated with serum enzyme elevations during therapy and or linked to instances of clinically apparent liver injury." /><meta name="og:title" content="Lecanemab" /><meta name="og:type" content="book" /><meta name="og:description" content="Lecanemab is a human monoclonal antibody to amyloid beta which has been approved for use in Alzheimer disease. Lecanemab has not been associated with serum enzyme elevations during therapy and or linked to instances of clinically apparent liver injury." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK589468/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/livertox/Lecanemab/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK589468/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="All Drug Records" href="/books/n/livertox/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" alt="Cover of LiverTox" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK589468_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK589468_dtls__"><div>Bethesda (MD): <a href="https://www.niddk.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Diabetes and Digestive and Kidney Diseases</a>; 2012-.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/livertox/">Drug Records</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/livertox/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/livertox/Lavender/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/livertox/Lefamulin/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK589468_"><span class="title" itemprop="name">Lecanemab</span></h1><p class="small">Last Update: <span itemprop="dateModified">February 10, 2023</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="Lecanemab.OVERVIEW"><h2 id="_Lecanemab_OVERVIEW_">OVERVIEW</h2><div id="Lecanemab.Introduction"><h3>Introduction</h3><p>Lecanemab is a human monoclonal antibody to amyloid beta which has been approved for use in Alzheimer disease. Lecanemab has not been associated with serum enzyme elevations during therapy and or linked to instances of clinically apparent liver injury.</p></div><div id="Lecanemab.Background"><h3>Background</h3><p>Lecanemab (lek an’ e mab) is a human monoclonal IgG1 antibody directed against aggregated forms of amyloid beta (β), which was developed as a potential therapy for Alzheimer disease, based upon the theory that the dementia and neurological decline in Alzheimer disease are caused by accumulation of amyloid β oligomers and fibrils in the frontal lobes of the brain. Studies in animal models and in humans demonstrated that the monoclonal antibody causes a decrease in amyloid β accumulation as shown by advanced imaging techniques. In a large, randomized controlled trial, lecanemab therapy was found to decrease the rate of cognitive decline in adults with early Alzheimer disease. Therapy did not reverse or stop cognitive impairment, and the long term, clinical benefit of the amount of benefit found in the trials of lecanemab remains uncertain. Lecanemab was given approval for use in early Alzheimer disease in 2023. It is available in single dose vials of 200 mg in 2 mL and 500 mg in 5 mL (both 100 mg/mL) under the brand name Leqembi. The recommended dose is 10 mg per kilogram body weight given intravenously (over approximately 1 hour) once every 2 weeks with regularly scheduled evaluations for efficacy and safety. Common side effects include infusion reactions, headache, falls, and amyloid related imaging abnormalities (ARIA) in the brain. Uncommon, potentially severe adverse reactions include hypersensitivity reactions and severe ARIA with edema, effusions or microhemorrhage.</p></div><div id="Lecanemab.Hepatotoxicity"><h3>Hepatotoxicity</h3><p>Serum aminotransferase elevations were infrequent (less than 1%) in patients receiving lecanemab in the large controlled trials in Alzheimer disease, and they occurred in a similar rate in placebo recipients. The serum <a class="def" href="/books/n/livertox/glossary/def-item/glossary.alanine-aminotransferase-alt-/">ALT</a> and <a class="def" href="/books/n/livertox/glossary/def-item/glossary.aspartate-aminotransferase-ast-/">AST</a> elevations were generally mild-to-moderate in severity, transient and asymptomatic. In the preregistration trials there were no instances of clinically apparent liver injury or severe hepatic adverse events attributed to lecanemab. Clinical use outside of randomized controlled trials has been limited so far.</p><p><a class="def" href="/books/n/livertox/glossary/def-item/glossary.likelihood-score/">Likelihood score</a>: E (unlikely cause of clinically apparent acute liver injury).</p></div><div id="Lecanemab.Mechanism_of_Injury"><h3>Mechanism of Injury</h3><p>The possible mechanisms by which lecanemab might cause liver injury are unclear. Monoclonal antibodies and immunoglobulins are generally taken up and metabolized intracellularly to short peptides and amino acids. There is no evidence to suggest that inhibition of amyloid β accumulation or increase in its clearance would trigger liver injury or autoimmune liver conditions.</p><p>Drug Class: <a href="/books/n/livertox/MonoclonalAntibodies/">Monoclonal Antibodies</a>, <a href="/books/n/livertox/AlzheimersDrugs/">Alzheimer Disease Agents</a></p><p>Other Alzheimer Monoclonal Antibodies: <a href="/books/n/livertox/Aducanumab/">Aducanumab</a></p></div></div><div id="Lecanemab.PRODUCT_INFORMATION"><h2 id="_Lecanemab_PRODUCT_INFORMATION_">PRODUCT INFORMATION</h2><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Lecanemab – Leqembi®</p><p>
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<b>DRUG CLASS</b>
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</p><p>Alzheimer Disease Agents</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Lecanemab" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div><div id="Lecanemab.CHEMICAL_FORMULA_AND_STRUCTURE"><h2 id="_Lecanemab_CHEMICAL_FORMULA_AND_STRUCTURE_">CHEMICAL FORMULA AND STRUCTURE</h2><div id="Lecanemab.Tc" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK589468/table/Lecanemab.Tc/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Lecanemab.Tc_lrgtbl__"><table><thead><tr><th id="hd_h_Lecanemab.Tc_1_1_1_1" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DRUG</th><th id="hd_h_Lecanemab.Tc_1_1_1_2" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CAS REGISTRY NO.</th><th id="hd_h_Lecanemab.Tc_1_1_1_3" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MOLECULAR FORMULA</th><th id="hd_h_Lecanemab.Tc_1_1_1_4" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">STRUCTURE</th></tr></thead><tbody><tr><td headers="hd_h_Lecanemab.Tc_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lecanemab</td><td headers="hd_h_Lecanemab.Tc_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/381126790" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">1260393-98-3</a>
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</td><td headers="hd_h_Lecanemab.Tc_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Monoclonal Antibody</td><td headers="hd_h_Lecanemab.Tc_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not Available</td></tr></tbody></table></div></div></div><div id="Lecanemab.ANNOTATED_BIBLIOGRAPHY"><h2 id="_Lecanemab_ANNOTATED_BIBLIOGRAPHY_">ANNOTATED BIBLIOGRAPHY</h2><p>References updated: 10 February 2023</p><p>Abbreviations: ARIA-E, amyloid related imaging abnormalities with edema, effusions or microhemorrhage.</p><ul class="first-line-outdent"><li><div class="bk_ref" id="Lecanemab.REF.roberson.2018">Roberson ED. Alzheimer Disease. Treatment of central nervous system degenerative disorders. In, Brunton LL, Hilal-Danan R, Knollman BC, eds. Goodman & Gilman's the pharmacological basis of therapeutics. 13th ed. New York: McGraw-Hill, 2018, pp. 333-5.<div><i>(Textbook of pharmacology and therapeutics).</i></div></div></li><li><div class="bk_ref" id="Lecanemab.REF.fda">FDA. <a href="https://www.accessdata.fda.gov/drugsatfda_docs/nda/2023/761269Orig1s000MedR.pdf" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>.accessdata<wbr style="display:inline-block"></wbr>.fda.gov/drugsatfda_docs<wbr style="display:inline-block"></wbr>/nda/2023/761269Orig1s000MedR.pdf</a>.<div><i>(Multidisciplinary FDA review of lecanemab in support of its approval for use in Alzheimer disease in the US with discussion of safety mentions that the laboratory findings from the prelicensure studies did not reveal a “safety signal for hepatic related events”).</i></div></div></li><li><div class="bk_ref" id="Lecanemab.REF.selkoe.2016.595">Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. <span><span class="ref-journal">EMBO Mol Med. </span>2016;<span class="ref-vol">8</span>:595–608.</span> [<a href="/pmc/articles/PMC4888851/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4888851</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27025652" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27025652</span></a>]<div>
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<i>(Analysis of the role of amyloid-β in the etiology of Alzheimer disease supported by findings that the dominant mutations in amyloid precursor protein [APP] or the protease that metabolizes presenilin and generates amyloid-β are associated with early onset dementia, suggesting that imbalance of generation and clearance of amyloid-β is the early and perhaps initiating factor in Alzheimer disease and that monoclonal antibody therapy by increasing clearance might help correct the dyshomeostasis).</i>
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</div></div></li><li><div class="bk_ref" id="Lecanemab.REF.sevigny.2016.50">Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. <span><span class="ref-journal">Nature. </span>2016;<span class="ref-vol">537</span>:50–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/27582220" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27582220</span></a>]<div>
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<i>(Among 165 patients with early Alzheimer disease treated with 1 of 4 doses of aducanumab [1, 3, 6, or 10 mg/kg] or placebo monthly for one year, those treated with the higher doses showed evidence of decrease in brain amyloid-β accumulation and a trend for clinical improvement, but also higher rates of vasogenic edema [37% to 40%] compared with placebo [5%]; ALT elevations arose in 4 of 125 [3.2%] on aducanumab vs none of 40 on placebo).</i>
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</div></div></li><li><div class="bk_ref" id="Lecanemab.REF.logovinsky.2016.14">Logovinsky V, Satlin A, Lai R, Swanson C, Kaplow J, Osswald G, Basun H, et al. Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selective Aβ antibody. <span><span class="ref-journal">Alzheimers Res Ther. </span>2016;<span class="ref-vol">8</span>:14.</span> [<a href="/pmc/articles/PMC4822297/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4822297</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27048170" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27048170</span></a>]<div>
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<i>(Among 60 patients with mild or moderate Alzheimer disease treated with one of 4 different doses of lecanemab or placebo for 12 months, treatment emergent adverse events were mild or moderate and similar to placebo with no symptomatic episodes of ARIA and the incidence of “out-of-range values in…clinical chemistry…parameters was comparable between different doses …and placebo”).</i>
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</div></div></li><li><div class="bk_ref" id="Lecanemab.REF.swanson.2021.80">Swanson CJ, Zhang Y, Dhadda S, Wang J, Kaplow J, Lai RYK, Lannfelt L, et al. A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody. <span><span class="ref-journal">Alzheimers Res Ther. </span>2021;<span class="ref-vol">13</span>:80.</span> [<a href="/pmc/articles/PMC8053280/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8053280</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/33865446" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33865446</span></a>]<div>
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<i>(Among 854 adults with early Alzheimer disease treated with one of 5 dose regimens of lecanemab or placebo for 18 months, a dose of 10 mg/kg given intravenously every 2 weeks yielded the optimal results in decreasing the decline in cognitive impairment and in decreasing amyloid beta burden with only mild-to-moderate adverse events including infusion related reactions in 20% [vs 3% with placebo], ARIA-E in 10% [vs 0.8% with placebo] and with “no relative changes between lecanemab and placebo in labs”).</i>
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</div></div></li><li><div class="bk_ref" id="Lecanemab.REF7">The Lancet. Lecanemab for Alzheimer's disease: tempering hype and hope. <span><span class="ref-journal">Lancet. </span>2022;<span class="ref-vol">400</span>(10367):1899.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/36463893" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 36463893</span></a>]<div>
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<i>(Editorial on the status of lecanemab therapy for Alzheimer disease stresses the promise of the evolving studies, but that the difference of 0.45 point [of a total of 18 points] in the progression of cognitive decline between lecanemab and placebo therapy is of unclear clinical significance and long term studies will be needed to establish the its role in management of Alzheimer disease).</i>
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</div></div></li><li><div class="bk_ref" id="Lecanemab.REF.van_dyck.2023.9">van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, Kanekiyo M, et al. Lecanemab in early Alzheimer's disease. <span><span class="ref-journal">N Engl J Med. </span>2023;<span class="ref-vol">388</span>:9–21.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/36449413" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 36449413</span></a>]<div>
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<i>(Among 1795 adults with early Alzheimer disease treated with lecanemab or placebo intravenously every two weeks for 18 months, there was less progression of cognitive decline and greater reduction in brain amyloid burden with lecanemab therapy, which was associated with a slightly higher total [89% vs 82%] and serious adverse events [14% vs 11%], most commonly infusion related reactions [26% vs 7%], ARIA-E [12.6% vs 1.7%], headache [11% vs 8%] and falls 10.4% vs 8.1%]; no mention of ALT elevations or hepatotoxicity).</i>
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</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pmc&DbFrom=books&Cmd=Link&LinkName=books_pmc_refs&IdsFromResult=5428954" ref="log$=recordlinks">PMC</a><div class="brieflinkpop offscreen_noflow">PubMed Central citations</div></li><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=pubmed&DbFrom=books&Cmd=Link&LinkName=books_pubmed_refs&IdsFromResult=5428954" ref="log$=recordlinks">PubMed</a><div class="brieflinkpop offscreen_noflow">Links to PubMed</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/37902139" ref="ordinalpos=1&linkpos=1&log$=relatedarticles&logdbfrom=pubmed">Novel anti-amyloid-beta (Aβ) monoclonal antibody lecanemab for Alzheimer's disease: A systematic review.</a><span class="source">[Int J Immunopathol Pharmacol. ...]</span><div class="brieflinkpop offscreen_noflow">Novel anti-amyloid-beta (Aβ) monoclonal antibody lecanemab for Alzheimer's disease: A systematic review.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Chowdhury S, Chowdhury NS. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Int J Immunopathol Pharmacol. 2023 Jan-Dec; 37:3946320231209839. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/36449413" ref="ordinalpos=1&linkpos=2&log$=relatedarticles&logdbfrom=pubmed">Lecanemab in Early Alzheimer's Disease.</a><span class="source">[N Engl J Med. 2023]</span><div class="brieflinkpop offscreen_noflow">Lecanemab in Early Alzheimer's Disease.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, Kanekiyo M, Li D, Reyderman L, Cohen S, et al. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">N Engl J Med. 2023 Jan 5; 388(1):9-21. Epub 2022 Nov 29.</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/37334596" ref="ordinalpos=1&linkpos=3&log$=relatedarticles&logdbfrom=pubmed">The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes.</a><span class="source">[J Alzheimers Dis. 2023]</span><div class="brieflinkpop offscreen_noflow">The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Kepp KP, Sensi SL, Johnsen KB, Barrio JR, Høilund-Carlsen PF, Neve RL, Alavi A, Herrup K, Perry G, Robakis NK, et al. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">J Alzheimers Dis. 2023; 94(2):497-507. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/34251780" ref="ordinalpos=1&linkpos=4&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Aducanumab.</a><span class="source">[LiverTox: Clinical and Researc...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Aducanumab.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/39475512" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Donanemab.</a><span class="source">[LiverTox: Clinical and Researc...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Donanemab.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012</em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed_reviews&uid=36862819" ref="ordinalpos=1&log$=relatedreviews_seeall&logdbfrom=pubmed">See reviews...</a><a class="seemore" href="/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=36862819" ref="ordinalpos=1&log$=relatedarticles_seeall&logdbfrom=pubmed">See all...</a></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Recent Activity</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="Shutter"></a></div><div class="portlet_content"><div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" id="HTDisplay" class=""><div class="action"><a href="javascript:historyDisplayState('ClearHT')">Clear</a><a href="javascript:historyDisplayState('HTOff')" class="HTOn">Turn Off</a><a href="javascript:historyDisplayState('HTOn')" class="HTOff">Turn On</a></div><ul id="activity"><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67c8e00ab15b832ebc0cb057">Lecanemab - 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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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