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class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-handbook-lrg.png" alt="Cover of The NCBI Handbook" /></a></div><div class="bkr_bib"><h1 id="_NBK21101_"><span itemprop="name">The NCBI Handbook</span></h1><div>Editors:</div><div class="contrib half_rhythm"><span itemprop="editor">Jo McEntyre</span></div><div class="contrib half_rhythm"><span itemprop="editor">Jim Ostell</span></div><div class="affiliation small">National Center for Biotechnology Information</div><div class="half_rhythm">Bethesda (MD): <a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Center for Biotechnology Information (US)</span></a>; <span itemprop="datePublished">2002</span>-.</div><div><a href="/books/about/copyright/">Copyright Notice</a></div><a class="btn wsprkl bkr_rd" href="/books/n/handbook/Part1.bxml/?report=reader">Read</a></div><div class="bkr_clear"></div></div><div class="bkr_bottom_sep bkr_bottom_margin body-content whole_rhythm"><div itemprop="description"><p>Bioinformatics consists of a computational approach to biomedical information management
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and analysis. It is being used increasingly as a component of research within both
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academic and industrial settings and is becoming integrated into both undergraduate and
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postgraduate curricula. The new generation of biology graduates is emerging with
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experience in using bioinformatics resources and, in some cases, programming skills.</p><p>The National Center for Biotechnology Information (NCBI) is one of the world's premier
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Web sites for biomedical and bioinformatics research. Based within the National Library
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of Medicine at the National Institutes of Health, USA, the NCBI hosts many databases
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used by biomedical and research professionals. The services include PubMed, the
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bibliographic database; GenBank, the nucleotide sequence database; and the BLAST
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algorithm for sequence comparison, among many others.</p><p>Although each NCBI resource has online help documentation associated with it, there is no
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cohesive approach to describing the databases and search engines, nor any significant
|
|
information on how the databases work or how they can be leveraged, for bioinformatics
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research on a larger scale. The NCBI Handbook is designed to address this information
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gap.</p><p>All of our users know how to execute a straightforward PubMed or BLAST search. However,
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feedback from help desk personnel and booth staff at scientific meetings suggests that
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people often want to know how to use our resources in a more sophisticated manner and
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are frequently unaware of less well-known databases that might be helpful to them. The
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intended audience for The NCBI Handbook is, therefore, the growing number of scientists
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and students who would like a more in-depth guide to NCBI resources—powerusers
|
|
and aspiring powerusers.</p><p>The NCBI Handbook is focused on the relatively stable information about each resource; it
|
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is not a point-and-click user guide (this type of information can be found in the online
|
|
help documents, referred to frequently but not repeated, in the Handbook). Each chapter
|
|
is devoted to one service; after a brief overview on using the resource, there is an
|
|
account of how the resource works, including topics such as how data are included in a
|
|
database, database design, query processing, and how the different resources relate to
|
|
each other. For example, the BLAST chapter briefly describes what to use BLAST for, the
|
|
various varieties of the BLAST algorithm, and BLAST statistics, before discussing output
|
|
formats, query processing, and tips for setting up a BLAST database. A certain amount of
|
|
biological knowledge is assumed.</p><p>The online content will be updated when necessary, although major changes are not
|
|
expected to occur more than once every few years. (For example, PubMed query processing
|
|
does not change dramatically year after year.) We hope that The NCBI Handbook will
|
|
provide a valuable reference for anyone who wants to use our resources more
|
|
effectively.</p></div></div></div><div class="fm-sec"><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK21101</span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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