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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/epacctetscapocpv/fm-ack/" title="Next page in this title">Next ></a></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=349776&Lab=CCTE&showcriteria=2&keyword=CCTE&timstype=PUBLISHED+REPORT&timssubtypeid=&epanumber=&ombcat=Any&datebeginpublishedpresented=10/28/2010&dateendpublishedpresented=&datebeginupdated=&dateendupdated=&deid=&personname=&personid=&role=Any&journalname=&journalid=&publishername=&publisherid=&sortby=pubDate&count=25" title="U.S. Environmental Protection Agency" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-epacctetscapocpv-lrg.png" alt="Cover of A Proof-of-Concept Case Study Integrating Publicly Available Information to Screen Candidates for Chemical Prioritization under TSCA" /></a><div class="icnblk_cntnt"><h1 id="_NBK605713_"><span itemprop="name">A Proof-of-Concept Case Study Integrating Publicly Available Information to Screen Candidates for Chemical Prioritization under TSCA</span></h1><div class="half_rhythm">Washington (DC): <a href="https://www.epa.gov/aboutepa/about-center-computational-toxicology-and-exposure-ccte" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">U.S. Environmental Protection Agency</span></a>; <span itemprop="datePublished">2021 Jun</span>.<div class="small">Report No.: EPA/600/R-21-106</div></div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK605713" data-jigconfig="modal:true">Copyright and
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For more information, see the <a href="/books/about/copyright/">Bookshelf Copyright Notice</a>.</div></div><div class="bk_noprnt"><form method="get" action="/books/n/epacctetscapocpv/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK605713_toc_fm-ack" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK605713_toc_fm-ack"><a class="toc-item" href="/books/n/epacctetscapocpv/fm-ack/">Acknowledgements</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_fm-ch1"><a class="toc-item" href="/books/n/epacctetscapocpv/fm-ch1/">Disclaimer</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_fm-ch2"><a class="toc-item" href="/books/n/epacctetscapocpv/fm-ch2/">Reviewers</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_abb"><a class="toc-item" href="/books/n/epacctetscapocpv/abb/">List of Abbreviations and Acronyms</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch1"><a class="toc-item" href="/books/n/epacctetscapocpv/ch1/">1. Executive Summary</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch2"><a class="toc-item" href="/books/n/epacctetscapocpv/ch2/">2. Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch3"><a class="toc-item" href="/books/n/epacctetscapocpv/ch3/">3. Background</a><ul id="toc_lst_NBK605713_toc_ch3" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch3_s1"><a class="toc-item" href="/books/n/epacctetscapocpv/ch3/#ch3.s1">3.1. Development and Implementation of New Approach Methods Under TSCA</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch3_s2"><a class="toc-item" href="/books/n/epacctetscapocpv/ch3/#ch3.s2">3.2. Evaluating Existing Chemicals Under TSCA</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch3_s3"><a class="toc-item" href="/books/n/epacctetscapocpv/ch3/#ch3.s3">3.3. Public Engagement</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch4"><a class="toc-item" href="/books/n/epacctetscapocpv/ch4/">4. Public Information Curation and Synthesis (PICS) Approach</a><ul id="toc_lst_NBK605713_toc_ch4" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch4_s1"><a class="toc-item" href="/books/n/epacctetscapocpv/ch4/#ch4.s1">4.1. Overview of the PICS Approach</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch4_s2"><a class="toc-item" href="/books/n/epacctetscapocpv/ch4/#ch4.s2">4.2. What the PICS Approach is Intended to Accomplish</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch4_s3"><a class="toc-item" href="/books/n/epacctetscapocpv/ch4/#ch4.s3">4.3. What the PICS Approach is Not Intended to Accomplish</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch5"><a class="toc-item" href="/books/n/epacctetscapocpv/ch5/">5. A Proof-of-Concept Case Study</a><ul id="toc_lst_NBK605713_toc_ch5" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch5_s1"><a class="toc-item" href="/books/n/epacctetscapocpv/ch5/#ch5.s1">5.1. Chemical Substance Selection, Curation and Quality Control</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch5_s2"><a class="toc-item" href="/books/n/epacctetscapocpv/ch5/#ch5.s2">5.2. Scientific Domain Metric Assessment</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch5_s3"><a class="toc-item" href="/books/n/epacctetscapocpv/ch5/#ch5.s3">5.3. Scientific Domain Metric Calculation</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch5_s4"><a class="toc-item" href="/books/n/epacctetscapocpv/ch5/#ch5.s4">5.4. Information Availability Metric</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch5_s5"><a class="toc-item" href="/books/n/epacctetscapocpv/ch5/#ch5.s5">5.5. Results of the Proof-of-Concept Analysis</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch5_s6"><a class="toc-item" href="/books/n/epacctetscapocpv/ch5/#ch5.s6">5.6. Overall Limitations and Long-term Options</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch6"><a class="toc-item" href="/books/n/epacctetscapocpv/ch6/">6. Summary</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_ch7"><a class="toc-item" href="/books/n/epacctetscapocpv/ch7/">7. Conclusion</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_appa"><a class="toc-item" href="/books/n/epacctetscapocpv/appa/">Appendix A. Proof-of-Concept (POC) Subset of the Non-confidential TSCA Active Inventory</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_appb"><a class="toc-item" href="/books/n/epacctetscapocpv/appb/">Appendix B. Detailed Information on Data Sources used in the PICS Approach</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_appc"><a class="toc-item" href="/books/n/epacctetscapocpv/appc/">Appendix C. Quality Assurance Recommendations to Efficiently Review Datasets to Support Candidate Chemical Identification for TSCA</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_appd"><a class="toc-item" href="/books/n/epacctetscapocpv/appd/">Appendix D. Definition of Exposure Pathways for Calculating the Susceptible Population Domain Metric</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_appe"><a class="toc-item" href="/books/n/epacctetscapocpv/appe/">Appendix E. Public Information Curation and Synthesis (PICS) Output for Proof-of-Concept (POC) Subset of the Non-confidential TSCA Active Inventory</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_appf"><a class="toc-item" href="/books/n/epacctetscapocpv/appf/">Appendix F. Comparison of Individual Scientific Domain Metrics for the POC238 and Non-confidential TSCA Active Inventory</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_appg"><a class="toc-item" href="/books/n/epacctetscapocpv/appg/">Appendix G. Information Availability Metric Calculation</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_app1"><a class="toc-item" href="/books/n/epacctetscapocpv/app1/">PEER REVIEW PLAN</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_app2"><a class="toc-item" href="/books/n/epacctetscapocpv/app2/">EPA Response to External Peer Review of A Proof-of-Concept Case Study Integrating Publicly Available Information to Screen Candidates for Chemical Pre- Prioritization under TSCA (TSCA POC)</a></li><li class="half_rhythm" id="toc_itm_NBK605713_toc_app3"><a class="toc-item" href="/books/n/epacctetscapocpv/app3/">Peer Review Report</a></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div><h4 class="inline">Suggested citation:</h4><p>USEPA 2021. A Proof-of-Concept Case Study Integrating Publicly Available Information to Screen Candidates for Chemical Pre-Prioritization under TSCA. June 2021. U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention and Office of Research and Development, Washington, DC. EPA/600/R-21-106.</p></div></div></div>
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