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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/epaccteetapstdmeth/abb/" title="Next page in this title">Next ></a></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=360671&Lab=CCTE&showcriteria=2&keyword=CCTE&timstype=PUBLISHED+REPORT&timssubtypeid=&epanumber=&ombcat=Any&datebeginpublishedpresented=10/28/2010&dateendpublishedpresented=&datebeginupdated=&dateendupdated=&deid=&personname=&personid=&role=Any&journalname=&journalid=&publishername=&publisherid=&sortby=pubDate&count=25" title="U.S. Environmental Protection Agency" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-epaccteetapstdmeth-lrg.png" alt="Cover of Standard Methods for Development of EPA Transcriptomic Assessment Products (ETAPs)" /></a><div class="icnblk_cntnt"><h1 id="_NBK606191_"><span itemprop="name">Standard Methods for Development of EPA Transcriptomic Assessment Products (ETAPs)</span></h1><p class="contrib-group"><span itemprop="author">Scott Auerbach</span>, <span itemprop="author">Warren Casey</span>, <span itemprop="author">Dan Chang</span>, <span itemprop="author">John Cowden</span>, <span itemprop="author">Sarah Davidson-Fritz</span>, <span itemprop="author">Jeffry Dean</span>, <span itemprop="author">Mike DeVito</span>, <span itemprop="author">Logan Everett</span>, <span itemprop="author">Alison H. Harrill</span>, <span itemprop="author">Susan Hester</span>, <span itemprop="author">Michael Hughes</span>, <span itemprop="author">Jason Lambert</span>, <span itemprop="author">Lucina Lizarraga</span>, <span itemprop="author">Roman Mezencev</span>, <span itemprop="author">Grace Patlewicz</span>, <span itemprop="author">Kristina Thayer</span>, <span itemprop="author">Russell S. Thomas</span>, <span itemprop="author">Kelsey Vitense</span>, and <span itemprop="author">Leah Wehmas</span>.</p><a data-jig="ncbitoggler" href="#__NBK606191_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK606191_ai__"><p class="contrib-group"><h4>Authors</h4><span itemprop="author">Scott Auerbach</span>,<sup>1</sup> <span itemprop="author">Warren Casey</span>,<sup>2</sup> <span itemprop="author">Dan Chang</span>,<sup>3</sup> <span itemprop="author">John Cowden</span>,<sup>4</sup> <span itemprop="author">Sarah Davidson-Fritz</span>,<sup>5</sup> <span itemprop="author">Jeffry Dean</span>,<sup>6</sup> <span itemprop="author">Mike DeVito</span>,<sup>7</sup> <span itemprop="author">Logan Everett</span>,<sup>8</sup> <span itemprop="author">Alison H. Harrill</span>,<sup>9</sup> <span itemprop="author">Susan Hester</span>,<sup>10</sup> <span itemprop="author">Michael Hughes</span>,<sup>11</sup> <span itemprop="author">Jason Lambert</span>,<sup>12</sup> <span itemprop="author">Lucina Lizarraga</span>,<sup>13</sup> <span itemprop="author">Roman Mezencev</span>,<sup>14</sup> <span itemprop="author">Grace Patlewicz</span>,<sup>15</sup> <span itemprop="author">Kristina Thayer</span>,<sup>16</sup> <span itemprop="author">Russell S. Thomas</span>,<sup>17</sup> <span itemprop="author">Kelsey Vitense</span>,<sup>18</sup> and <span itemprop="author">Leah Wehmas</span><sup>19</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup> NTP/DTT/NIEHS/NIH</div><div class="affiliation"><sup>2</sup> NTP/DTT/NIEHS/NIH</div><div class="affiliation"><sup>3</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>4</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>5</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>6</sup> EPA/ORD/CPHEA</div><div class="affiliation"><sup>7</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>8</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>9</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>10</sup> EPA/ORD/CCTE (retired)</div><div class="affiliation"><sup>11</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>12</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>13</sup> EPA/ORD/CPHEA</div><div class="affiliation"><sup>14</sup> EPA/ORD/CPHEA</div><div class="affiliation"><sup>15</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>16</sup> EPA/ORD/CPHEA</div><div class="affiliation"><sup>17</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>18</sup> EPA/ORD/CCTE</div><div class="affiliation"><sup>19</sup> EPA/ORD/CCTE</div></div><div class="half_rhythm">Washington (DC): <a href="https://www.epa.gov/aboutepa/about-center-computational-toxicology-and-exposure-ccte" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">U.S. Environmental Protection Agency</span></a>; <span itemprop="datePublished">2024 Mar</span>.</div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK606191" data-jigconfig="modal:true">Copyright and
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For more information, see the <a href="/books/about/copyright/">Bookshelf Copyright Notice</a>.</div></div><div class="bk_noprnt"><form method="get" action="/books/n/epaccteetapstdmeth/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK606191_toc_abb" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK606191_toc_abb"><a class="toc-item" href="/books/n/epaccteetapstdmeth/abb/">ABBREVIATIONS</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_fm-ch1"><a class="toc-item" href="/books/n/epaccteetapstdmeth/fm-ch1/">CONTRIBUTORS | REVIEWERS</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch1"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch1/">1. PURPOSE AND APPLICABILITY</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch2"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch2/">2. OVERVIEW AND PRINCIPLES OF THE METHOD</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/">3. METHODS</a><ul id="toc_lst_NBK606191_toc_ch3" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3_s1"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/#ch3.s1">3.1. CANDIDATE SUBSTANCE INITIAL SCREENING</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3_s2"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/#ch3.s2">3.2. SYSTEMATIC EVIDENCE MAP DEVELOPMENT</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3_s3"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/#ch3.s3">3.3. EVIDENCE MAP REVIEW AND PRE-STUDY EVALUATION</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3_s4"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/#ch3.s4">3.4. 5-DAY <i>IN VIVO</i> TRANSCRIPTOMIC STUDIES AND ANALYSIS</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3_s5"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/#ch3.s5">3.5. HUMAN EQUIVALENT DOSE</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3_s6"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/#ch3.s6">3.6. TRANSCRIPTOMIC REFERENCE VALUES</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3_s7"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/#ch3.s7">3.7. ETAP REPORTING</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch3_s8"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch3/#ch3.s8">3.8. INTERNAL AND EXTERNAL REVIEW OF ETAPs</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_ch4"><a class="toc-item" href="/books/n/epaccteetapstdmeth/ch4/">4. COMPARISON OF TRANSCRIPTOMIC REFERENCE VALUES WITH TRADITIONAL RfDs</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_rl_r1"><a class="toc-item" href="/books/n/epaccteetapstdmeth/rl.r1/">5. REFERENCES</a></li><li class="half_rhythm" id="toc_itm_NBK606191_toc_app1"><a class="toc-item" href="/books/n/epaccteetapstdmeth/app1/">6. APPENDIX – STANDARD TEMPLATE</a></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div><p>Final Report</p></div><div><p>Contributors</p><p>Reeder Sams</p><p>CCTE Deputy Center Director</p><p>Sid Hunter</p><p>CCTE/BCTD Division Director</p><p>Wayne Cascio</p><p>CPHEA Center Director</p><p>Kay Holt</p><p>CPHEA Deputy Center Director</p><p>Samantha Jones</p><p>CPHEA Associate Director</p><p>Ravi Subramaniam</p><p>CPHEA/CPAD/TEABD Branch Chief</p><p>Glenn Rice</p><p>CPHEA/CPAD/TEABC Branch Chief</p><p>John Bucher</p><p>NTP/DTT/NIEHS/NIH</p><p>Timothy Buckley</p><p>EPA/ORD/CCTE</p><p>Peter Egeghy</p><p>EPA/ORD/CCTE</p><p>Katie Paul-Friedman</p><p>EPA/ORD/CCTE</p><p>Joshua Harrill</p><p>EPA/ORD/CCTE</p><p>Sid Hunter</p><p>EPA/ORD/CCTE</p><p>Kristin Isaacs</p><p>EPA/ORD/CCTE</p><p>Richard Judson</p><p>EPA/ORD/CCTE</p><p>Jonathan Kaiser</p><p>EPA/ORD/CPHEA</p><p>Scott Masten</p><p>NTP/DTT/NIEHS/NIH</p><p>Fred Parham</p><p>NTP/DTT/NIEHS/NIH</p><p>Dan Petersen</p><p>EPA/ORD/CPHEA</p><p>Allison Phillips</p><p>EPA/ORD/CPHEA</p><p>Jon Sobus</p><p>EPA/ORD/CCTE</p><p>Daniel Villeneuve</p><p>EPA/ORD/CCTE</p><p>Paul White</p><p>EPA/ORD/CPHEA</p><p>Antony Williams</p><p>EPA/ORD/CCTE</p><p>George Woodall</p><p>EPA/ORD/CPHEA</p><p>Jay Zhao</p><p>EPA/ORD/CPHEA</p></div><div><p><b>DISCLAIMER</b>: This document has been reviewed in accordance with the U.S. Environmental Protection Agency’s (EPA) peer and administrative review policies and approved for publication. Peer review was performed by the EPA Board of Scientific Counselors and was subject to public comment. Any mention of trade names, products, or services does not imply an endorsement by the U.S. government or the EPA. EPA does not endorse any commercial products, services, or enterprises.</p></div></div></div>
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