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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/pdqcis/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" alt="Cover of PDQ Cancer Information Summaries" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>PDQ Cancer Information Summaries [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK83984_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK83984_dtls__"><div>Bethesda (MD): <a href="http://www.cancer.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Cancer Institute (US)</a>; 2002-.</div></div><div class="half_rhythm"></div><div class="bk_noprnt"><form method="get" action="/books/n/pdqcis/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK83984_"><span class="title" itemprop="name">Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®)</span></h1><div class="subtitle whole_rhythm">Patient Version</div><p class="contrib-group"><span itemprop="author">PDQ Integrative, Alternative, and Complementary Therapies Editorial Board</span>.</p><p class="small">Published online: June 17, 2021.</p><p class="small">Created: <span itemprop="datePublished">February 1, 2012</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><p id="CDR0000719565__470">This PDQ cancer information summary has current information about the use of nutrition and dietary supplements for reducing the risk of developing prostate cancer or for treating prostate cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p><p id="CDR0000719565__471">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change. The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board.</p></div><div id="CDR0000719565__1"><h2 id="_CDR0000719565__1_">Introduction</h2><p id="CDR0000719565__33">Men in the United States get <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a> more than any other type of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> except <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445084/" class="def">skin cancer</a>. It occurs mainly in older men. In the United States, about 1 in every 9 men will be <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnosed</a> with prostate cancer during his lifetime. Most men with prostate cancer do not die of it.</p><p id="CDR0000719565__57"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044964/" class="def">Complementary and alternative medicine</a> (CAM) is a form of treatment used in addition to (complementary) or instead of (alternative) <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044930/" class="def">standard treatments</a>. </p><p id="CDR0000719565__34">CAM use among men with prostate cancer is common. Studies of why men with prostate cancer decide to use CAM show that their choice is based on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000689078/" class="def">medical history</a>, beliefs about the safety and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> of CAM compared to standard treatments, and a need to feel in control of their treatment.</p><p id="CDR0000719565__702">CAM treatments used by men with prostate cancer include certain foods, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000463714/" class="def">herbs</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044744/" class="def">vitamins</a>, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045787/" class="def">minerals</a>.</p><p id="CDR0000719565__705">Different types of research have been done to study the use of CAM in prostate cancer. These study types include the following:</p><ul id="CDR0000719565__706"><li class="half_rhythm"><div>Combined study: A combined study analyzes data from more than one study done on the same topic, such as the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">response</a> to a dietary supplement, risk of getting cancer, or treatment of cancer. The results of a combined study are usually stronger than the results of any study by itself. A combined study is also called a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000691484/" class="def">meta-analysis</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000561718/" class="def">Population study</a>: A population study looks at a group of people who are part of the general population and share a common characteristic, such as age, sex, or health <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a>. This group of people may be studied for different reasons, such as their response to a dietary supplement or risk of getting cancer. A population study is also called an epidemiologic study.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">Clinical trial</a>: A clinical trial looks at how well new medical approaches work in people. These studies may test new methods of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046171/" class="def">screening</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevention</a>, diagnosis, or treatment of cancer. Clinical trials with a small number of people or when the treatment is not <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000322881/" class="def">randomly</a> assigned are not included in this summary. See the clinical trial sections of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on clinical trials done using <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044697/" class="def">nutrients</a> or supplements.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">Laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a>: In laboratory studies, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> are used to test a substance to find out if it is likely to have any anticancer effects. In animal studies, tests are done to see if a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000348921/" class="def">drug</a>, procedure, or treatment is safe and effective in animals. Laboratory and animal studies are done before a substance is tested in people.</div></li></ul><p id="CDR0000719565__707">CAM treatments have been studied to see if their use lowers the risk of getting prostate cancer, kills prostate cancer cells, or lowers the risk that cancer will come back after treatment. Most of these studies use <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046540/" class="def">prostate-specific antigen</a> (PSA) levels as an indirect measure of whether the treatment was effective. This is a weaker measure of how well the treatment works than direct measures, such as fewer new cases of prostate cancer, or a smaller tumor size or lower rate of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045861/" class="def">recurrence</a> after treatment for prostate cancer.</p><p id="CDR0000719565__55">This <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044271/" class="def">PDQ</a> summary has sections about the use of specific foods and dietary supplements to prevent or treat prostate cancer:</p><ul id="CDR0000719565__234"><li class="half_rhythm"><div><a href="#CDR0000719565__446">Calcium</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__175">Green Tea</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__3">Lycopene</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__61">Modified Citrus Pectin</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__79">Pomegranate</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__250">Selenium</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__95">Soy</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__295">Vitamin D</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__269">Vitamin E</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__447">Combination Therapies</a></div></li><li class="half_rhythm"><div><a href="#CDR0000719565__347">Other Prostate Health Supplements</a></div></li></ul><p id="CDR0000719565__672">Each section includes the following information for each food or dietary supplement:</p><ul id="CDR0000719565__36"><li class="half_rhythm"><div>How it is given or taken.</div></li><li class="half_rhythm"><div>Results of studies done in people.</div></li><li class="half_rhythm"><div>Side effects or risks.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">Food and Drug Administration</a> (FDA) information.</div></li></ul></div><div id="CDR0000719565__56"><h2 id="_CDR0000719565__56_">Overview of CAM Use in Prostate Cancer</h2><p id="CDR0000719565__37">Studies of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044384/" class="def">CAM</a> use to treat <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a> have shown the following:</p><ul id="CDR0000719565__42"><li class="half_rhythm"><div>Men who have prostate cancer are more likely to take <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a> and eat certain foods than men who do not have prostate cancer.</div></li><li class="half_rhythm"><div>Men who have prostate cancer and who have healthy eating habits (for example, eating lots of fish rich in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045809/" class="def">omega-3 fatty acids</a> and vegetables) are more likely to take dietary supplements.</div></li><li class="half_rhythm"><div>Men who have prostate cancer use CAM treatments to help boost the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046356/" class="def">immune system</a>, improve <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045417/" class="def">quality of life</a>, and lower the risk of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> coming back, but only half of them tell their doctors about their use of CAM.</div></li></ul><p id="CDR0000719565__43">Studies of CAM use to lower prostate cancer risk or to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevent</a> it from coming back have shown the following:</p><ul id="CDR0000719565__44"><li class="half_rhythm"><div>A study of men with a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000302456/" class="def">family history</a> of prostate cancer found that over half used <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044744/" class="def">vitamins</a> or other dietary supplements for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046539/" class="def">prostate</a> health or to prevent cancer.</div></li><li class="half_rhythm"><div>A study of men at a prostate cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046171/" class="def">screening</a> clinic found that over half took multivitamins and some took <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000560646/" class="def">herbal supplements</a>.</div></li><li class="half_rhythm"><div>A study of prostate cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000450125/" class="def">survivors</a> found that up to one-third took vitamins or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045787/" class="def">minerals</a>.</div></li></ul><p id="CDR0000719565__691">See the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044271/" class="def">PDQ</a> summary on <a href="/books/n/pdqcis/CDR0000062853/">Prostate Cancer Prevention</a> for
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more information on prostate cancer prevention.</p></div><div id="CDR0000719565__446"><h2 id="_CDR0000719565__446_">Questions and Answers About Calcium</h2><ol id="CDR0000719565__409"><li id="CDR0000719565__410" class="half_rhythm"><div class="half_rhythm"><b>What is calcium?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045632/" class="def">Calcium</a> is a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045787/" class="def">mineral</a> that is needed for basic <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045020/" class="def">blood vessel</a>, muscle, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373935/" class="def">nerve</a> functioning, for sending signals from <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cell</a> to cell, and for releasing <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045713/" class="def">hormones</a>. It is the most common mineral in the body. The body stores calcium mainly in bone <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a>. </div></li><li id="CDR0000719565__411" class="half_rhythm"><div class="half_rhythm"><b>How is calcium given or taken?</b></div><div class="half_rhythm">The main sources of calcium are in foods and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a>. About one-third of dietary calcium comes from milk and milk products like cheese and yogurt. Vegetable sources include Chinese cabbage, kale, and broccoli. Foods may have calcium added, such as fruit juices and drinks, tofu, and cereals. </div><div class="half_rhythm">Most research about calcium and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a> risk has studied calcium in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044660/" class="def">diet</a> and not calcium in supplements. </div></li><li id="CDR0000719565__412" class="half_rhythm"><div class="half_rhythm"><b>Have any laboratory or animal studies
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been done using calcium?</b></div><div class="half_rhythm">See the <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__513">Laboratory/Animal/Preclinical Studies</a> section of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a> done using calcium.</div></li><li id="CDR0000719565__413" class="half_rhythm"><div class="half_rhythm"><b>Have any studies of calcium been done in people?</b></div><div class="half_rhythm">Studies of people in many parts of the world have been done to find out if there is a link between dairy products, calcium, and prostate cancer risk. The results of these studies have been mixed. Some studies have shown that calcium has an effect on the overall risk of developing prostate cancer or on stopping <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> from coming back after treatment, and others have not. Several studies have suggested that eating a large amount of calcium may increase the risk of having <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000478743/" class="def">advanced</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044058/" class="def">metastatic</a> prostate cancer.</div><div class="half_rhythm"><b>Combined studies</b><ul id="CDR0000719565__709"><li class="half_rhythm"><div>A 2005 review found a possible link between an increased risk of prostate cancer and a diet high in dairy products and calcium. </div></li><li class="half_rhythm"><div>A review of studies published between 1996 and 2006 found that milk and dairy products in the diet increased the risk of prostate cancer.</div></li><li class="half_rhythm"><div>A 2008 review of 45 studies found no link between dairy products and the risk of prostate cancer.</div></li><li class="half_rhythm"><div>A 2013 review for the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000753859/" class="def">U.S. Preventive Services Task Force</a> found that taking <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000427253/" class="def">vitamin D</a> and/or calcium supplements showed no overall effect on rates of cancer or deaths from cancer, including prostate cancer.</div></li><li class="half_rhythm"><div>A 2015 review of 32 studies found that high amounts of milk, low-fat milk, cheese, total dietary calcium, and dairy calcium in the diet may increase the risk of prostate cancer. Calcium supplements and non-dairy calcium were not linked with an increased risk of prostate cancer. </div></li></ul></div><div class="half_rhythm"><b>Population studies</b><ul id="CDR0000719565__695"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000561718/" class="def">Population studies</a> of dairy products, dietary calcium, and prostate cancer risk have shown mixed results. Age, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000455136/" class="def">body mass index</a> (BMI), and other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044697/" class="def">nutrients</a> in dairy products may affect study results.</div></li></ul></div><div class="half_rhythm"><b>Clinical trials</b><ul id="CDR0000719565__696"><li class="half_rhythm"><div>In a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045858/" class="def">randomized clinical trial</a> reported in 2005, men were given calcium or a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046688/" class="def">placebo</a> for 4 years and were followed for 12 years. During the first 6 years of the study, there were fewer cases of prostate cancer in the calcium group than in the placebo group. But after 10 years, there was no difference in the number of prostate cancers between the two groups.</div></li></ul></div></li><li id="CDR0000719565__415" class="half_rhythm"><div class="half_rhythm"><b>Is calcium approved by the U.S. Food and Drug Administration (FDA)
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for use as a cancer treatment in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of calcium as a treatment for cancer.</div><div class="half_rhythm">The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of calcium supplements may not be the same.</div></li></ol><div id="CDR0000719565__416"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_416_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__175"><h2 id="_CDR0000719565__175_">Questions and Answers About Green Tea</h2><ol id="CDR0000719565__176"><li id="CDR0000719565__177" class="half_rhythm"><div class="half_rhythm"><b>What is green tea?</b></div><div class="half_rhythm">Tea comes from the <i>Camellia sinensis</i> plant. The way tea leaves are processed determines whether green tea, black tea, or oolong tea is made. Green tea leaves are steamed and dried. </div><div class="half_rhythm">The health benefits studied in green tea are thought to be from <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000422394/" class="def">compounds</a> called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000256573/" class="def">polyphenols</a>. Polyphenols are a group of plant <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000643008/" class="def">chemicals</a> that include <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000686469/" class="def">catechins</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000043997/" class="def">antioxidants</a> that help protect <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> from damage). Catechins make up most of the polyphenols in green tea. </div><div class="half_rhythm">Catechins in green tea can vary widely, depending on the source of the tea leaves and the way they are processed. This makes it hard to identify most of the chemical factors linked to the health benefits of green tea. </div><div class="half_rhythm">Some studies suggest that green tea may protect against <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000748138/" class="def">heart</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045020/" class="def">blood vessel</a> disease.</div></li><li id="CDR0000719565__180" class="half_rhythm"><div class="half_rhythm"><b>How is green tea given or taken?</b></div><div class="half_rhythm">People usually drink green tea or take it as a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplement</a>.
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</div></li><li id="CDR0000719565__182" class="half_rhythm"><div class="half_rhythm"><b>Have any laboratory or animal studies
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been done using green tea?</b></div><div class="half_rhythm">See the <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__185">Laboratory/Animal/Preclinical Studies</a> section of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a> done using green tea.
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</div></li><li id="CDR0000719565__183" class="half_rhythm"><div class="half_rhythm"><b>Have any studies of green tea been done in people?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000561718/" class="def">Population studies</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a> have been done to find out if green tea can <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevent</a> or treat <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a>. Results have been mixed; some studies have shown a short-term decrease in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046540/" class="def">prostate-specific antigen</a> (PSA) level or a lower risk of having prostate cancer, and others have not. There is not enough evidence to know whether green tea can prevent or treat prostate cancer.</div><div class="half_rhythm"><b>Population studies</b><ul id="CDR0000719565__697"><li class="half_rhythm"><div>Overall, population studies suggest that green tea may help protect against prostate cancer in Asian populations. Prostate cancer deaths in Asia are among the lowest in the world. </div></li></ul></div><div class="half_rhythm"><b>Clinical trials</b><ul id="CDR0000719565__698"><li class="half_rhythm"><div>In two <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045858/" class="def">randomized clinical trials</a> in men at high risk of prostate cancer (high-grade <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044345/" class="def">prostatic intraepithelial neoplasia</a> [HGPIN]), those treated with green tea catechins had lower rates of prostate cancer than those treated with a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046688/" class="def">placebo</a>. A 2017 randomized clinical trial in men with HGPIN found that those treated with green tea catechins for 1 year had decreased PSA levels, though no decrease in rates of prostate cancer, compared with the placebo group. Overall, findings suggest that green tea catechins lower PSA levels and may lower the risk of prostate cancer in men at high risk for the disease.</div></li></ul>
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</div></li><li id="CDR0000719565__184" class="half_rhythm"><div class="half_rhythm"><b>Have any side effects or risks been reported from green tea?</b></div><div class="half_rhythm">A trial of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044068/" class="def">oral</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000389271/" class="def">green tea extract</a> in patients with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045301/" class="def">solid tumors</a> reported that drinking 7 to 8 Japanese-style cups (equal to 3 ½ to 4 cups U.S.) of tea consumed 3 times a day for 6 months was a safe <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044664/" class="def">dose</a>. </div><div class="half_rhythm">Clinical trials have reported on the safety of long-term use of green tea compounds to prevent prostate cancer. In a United States trial, men at risk of prostate cancer were given green tea extract or a placebo for 1 year. There were more <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> in the group receiving the green tea extract than in the group receiving the placebo.</div><div class="half_rhythm">In safety studies of green tea for men with prostate cancer, short-term green tea use for up to 90 days was well tolerated. One study found that the most reported side effects of green tea were headache, chest pain, or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045692/" class="def">gastrointestinal</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>, such as <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390302/" class="def">nausea</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000306496/" class="def">diarrhea</a>. These were mild except for two reports of trouble breathing and severe <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044103/" class="def">anorexia</a>. In men with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000478743/" class="def">advanced</a> prostate cancer, side effects reported include <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044043/" class="def">insomnia</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000450096/" class="def">confusion</a>, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000321374/" class="def">fatigue</a>. In rare cases, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046312/" class="def">liver</a> problems have occurred.
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</div></li><li id="CDR0000719565__185" class="half_rhythm"><div class="half_rhythm"><b>Is green tea approved by the U.S. Food and Drug Administration (FDA)
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for use as a cancer treatment in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of green tea as a treatment for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> or any other medical <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a>.</div><div class="half_rhythm">The FDA Division of Drug Oncology Products recommends that green tea extract be taken with food by participants in clinical trials and that <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390293/" class="def">liver function tests</a> be considered during treatment.
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</div><div class="half_rhythm">Green tea is available in the United States in food products and dietary supplements. The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of green tea supplements may not be the same.</div></li></ol><div id="CDR0000719565__236"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_236_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__3"><h2 id="_CDR0000719565__3_">Questions and Answers About Lycopene</h2><ol id="CDR0000719565__4"><li id="CDR0000719565__5" class="half_rhythm"><div class="half_rhythm"><b>What is lycopene?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044909/" class="def">Lycopene</a> is a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046132/" class="def">carotenoid</a> (a natural red coloring made by plants). It mixes with or dissolves in fats. Lycopene protects plants from light-related stress and helps them use the energy of the sun to make <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044697/" class="def">nutrients</a>. Lycopene is found in fruits and vegetables like tomatoes, apricots, guavas, and watermelons.</div><div class="half_rhythm">The main source of lycopene in the United States is tomato-based products. Lycopene is easier for the body to use when it is eaten in processed tomato products like tomato paste and tomato puree than in raw tomatoes. </div><div class="half_rhythm"> Lycopene has been studied for its role in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevention</a> of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000748138/" class="def">heart</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045020/" class="def">blood vessel</a> disease. </div></li><li id="CDR0000719565__6" class="half_rhythm"><div class="half_rhythm"><b>How is lycopene given or taken?</b></div><div class="half_rhythm">
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Lycopene may be eaten in food or taken in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a>. </div></li><li id="CDR0000719565__7" class="half_rhythm"><div class="half_rhythm"><b>Have any laboratory or animal studies
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been done using lycopene?</b></div><div class="half_rhythm">See the <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__9">Laboratory/Animal/Preclinical Studies</a> section of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a> done using lycopene.</div></li><li id="CDR0000719565__8" class="half_rhythm"><div class="half_rhythm"><b>Have any studies of lycopene been done in people?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000561718/" class="def">Population studies</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a> have been done to find out if lycopene can prevent or treat <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a>. Clinical trials have shown mixed results; some studies have shown a lower risk of having prostate cancer or a decrease in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046540/" class="def">prostate-specific antigen</a> (PSA) level, and others have not. There is not enough evidence to know whether lycopene can prevent or treat prostate cancer.</div><div class="half_rhythm"><b>Population and combined studies</b>
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<ul id="CDR0000719565__22"><li class="half_rhythm"><div>Some population studies in men have found that high amounts of lycopene in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044660/" class="def">diet</a> are linked with a lower risk of developing prostate cancer. </div></li><li class="half_rhythm"><div>Some studies have shown that lycopene levels in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a> of people with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> are lower than in those who do not have cancer. However, other studies have not shown this.</div></li><li class="half_rhythm"><div>Reviews done in 2015 and 2017 of combined studies analyzed lycopene in the diet and lycopene levels in the blood. Both reviews found that higher lycopene intake and higher blood levels of lycopene were linked with lower prostate cancer risk.</div></li><li class="half_rhythm"><div>A 2006 study done in men who took part in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044266/" class="def">National Cancer Institute's</a> Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial found no link between lycopene and tomatoes in the diet and prostate cancer risk in men with no <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000302456/" class="def">family history</a> of prostate cancer. However, in men with a family history of the disease, higher amounts of lycopene in the diet were linked with a lower risk of developing prostate cancer. </div></li></ul>
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</div><div class="half_rhythm">Sources and types of lycopene, types of diets, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046391/" class="def">genetic</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045873/" class="def">risk factors</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000527371/" class="def">obesity</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439432/" class="def">tobacco</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000463134/" class="def">alcohol</a> use, and other factors, may play a part in mixed study results. Most research has studied the effects of lycopene on the risk of all prostate cancers, and has not studied effects of lycopene on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000386213/" class="def">low-grade</a> prostate cancer compared with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000386205/" class="def">high-grade</a> prostate cancer.</div><div class="half_rhythm">There are other trials of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000688810/" class="def">combination therapies</a> that include lycopene in the <a href="#CDR0000719565__447">Combination Therapies</a> section of this summary.</div></li><li id="CDR0000719565__9" class="half_rhythm"><div class="half_rhythm"><b>Have any side effects or risks been reported from lycopene?</b></div><div class="half_rhythm">Lycopene has been given in many clinical trials with very few <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a>. Side effects, such as <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000306496/" class="def">diarrhea</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390302/" class="def">nausea</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390324/" class="def">vomiting</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476585/" class="def">bloating</a>, gassiness, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046604/" class="def">stomach</a> irritation have been reported. In one study, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a> went away when lycopene was taken with meals. </div></li><li id="CDR0000719565__10" class="half_rhythm"><div class="half_rhythm"><b>Is lycopene approved by the U.S. Food and Drug Administration (FDA)
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for use to prevent or treat cancer in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of lycopene as a treatment for cancer or any other medical <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a>.</div><div class="half_rhythm">Lycopene is deemed Generally Recognized as Safe by the FDA.</div><div class="half_rhythm">Lycopene is available in the United States in food products and dietary supplements. The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of lycopene supplements may not be the same.</div></li></ol><div id="CDR0000719565__149"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_149_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__61"><h2 id="_CDR0000719565__61_">Questions and Answers About Modified Citrus Pectin</h2><ol id="CDR0000719565__62"><li id="CDR0000719565__63" class="half_rhythm"><div class="half_rhythm"><b>What is modified citrus pectin?</b></div><div class="half_rhythm">Pectin is a substance made of small sugar <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045065/" class="def">molecules</a> that are linked together. Pectin is found in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cell</a> wall of most plants and has gel-like qualities that are useful in making many types of food and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000482419/" class="def">medicine</a>.</div><div class="half_rhythm">Citrus pectin is found in the peel and pulp of citrus fruits such as oranges, grapefruit, lemons, and limes. Citrus pectin can be modified (changed) during manufacturing so that it can be dissolved in water and absorbed by the body. This changed citrus pectin is called modified citrus pectin (MCP).
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</div></li><li id="CDR0000719565__66" class="half_rhythm"><div class="half_rhythm"><b>How is MCP given or taken?</b></div><div class="half_rhythm">
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MCP may be taken by mouth in powder or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000455334/" class="def">capsule</a> form.</div></li><li id="CDR0000719565__68" class="half_rhythm"><div class="half_rhythm"><b>Have any laboratory or animal studies
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been done using MCP?</b></div><div class="half_rhythm">See the <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__65">Laboratory/Animal/Preclinical Studies</a> section of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a> done using MCP.
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</div></li><li id="CDR0000719565__72" class="half_rhythm"><div class="half_rhythm"><b>Have any studies
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of MCP been done in people?</b></div><div class="half_rhythm">Few studies have been done in men with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a>. There is not enough evidence to know whether MCP has any effect on prostate cancer.
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</div></li><li id="CDR0000719565__75" class="half_rhythm"><div class="half_rhythm"><b>Have any side effects or risks been reported from MCP?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">Side effects</a> that have been reported include itching, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046604/" class="def">stomach</a> upset, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046684/" class="def">abdominal</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476584/" class="def">cramps</a>, gassiness, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000306496/" class="def">diarrhea</a>.
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</div></li><li id="CDR0000719565__77" class="half_rhythm"><div class="half_rhythm"><b>Is MCP approved by the U.S. Food and Drug Administration (FDA)
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for use to prevent or treat cancer in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of MCP as a treatment for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> or any other medical <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a>.</div><div class="half_rhythm">MCP is available in the United States in food products and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a>. The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of MCP supplements may not be the same.</div></li></ol><div id="CDR0000719565__158"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_158_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__79"><h2 id="_CDR0000719565__79_">Questions and Answers About Pomegranate</h2><ol id="CDR0000719565__80"><li id="CDR0000719565__81" class="half_rhythm"><div class="half_rhythm"><b>What is pomegranate?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000321386/" class="def">pomegranate</a> is a fruit grown in Asia and in the Mediterranean, East Indies, Africa, and the United States. Pomegranate has been used as <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000482419/" class="def">medicine</a> for hundreds of years.</div><div class="half_rhythm">The pomegranate is made up of the following:<ul id="CDR0000719565__83"><li class="half_rhythm"><div>The peel, which makes up half the fruit and contains <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000256573/" class="def">polyphenols</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045787/" class="def">minerals</a>.</div></li><li class="half_rhythm"><div>The seeds.</div></li><li class="half_rhythm"><div>The aril (the layer between the peel and the seeds), which contains phenolics and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000330168/" class="def">flavonoids</a> including anthocyanins, which give the pomegranate fruit and juice a red color.</div></li></ul></div></li><li id="CDR0000719565__84" class="half_rhythm"><div class="half_rhythm"><b>How is pomegranate given or taken?</b></div><div class="half_rhythm">
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Pomegranate fruit and juice may be taken as food, drink, or a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplement</a>.</div></li><li id="CDR0000719565__86" class="half_rhythm"><div class="half_rhythm"><b>Have any laboratory or animal studies
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been done using pomegranate?</b></div><div class="half_rhythm">See the <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__85">Laboratory/Animal/Preclinical Studies</a> section of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a> done using pomegranate.
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</div></li><li id="CDR0000719565__89" class="half_rhythm"><div class="half_rhythm"><b>Have any studies of pomegranate been done in people?</b></div><div class="half_rhythm">In a 2015 study, 183 men with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045862/" class="def">recurrent</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a> were <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000322881/" class="def">randomly</a> assigned to receive either pomegranate juice, pomegranate extract, or a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046688/" class="def">placebo</a>. The study found no difference in how fast the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046540/" class="def">prostate-specific antigen</a> (PSA) level rose between the 3 groups. There is not enough evidence to know whether pomegranate can <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevent</a> or treat prostate cancer.
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</div></li><li id="CDR0000719565__91" class="half_rhythm"><div class="half_rhythm"><b>Have any side effects or risks been reported from pomegranate?</b></div><div class="half_rhythm">No serious <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> have been reported from the use of pomegranate.
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</div></li><li id="CDR0000719565__93" class="half_rhythm"><div class="half_rhythm"><b>Is pomegranate approved by the U.S. Food and Drug Administration (FDA)
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for use to prevent or treat cancer in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of pomegranate as a treatment for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> or any other medical <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a>.
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</div><div class="half_rhythm">Pomegranate is available in the United States in food products and dietary supplements. The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of pomegranate supplements may not be the same.</div></li></ol><div id="CDR0000719565__152"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_152_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__250"><h2 id="_CDR0000719565__250_">Questions and Answers About Selenium</h2><ol id="CDR0000719565__251"><li id="CDR0000719565__252" class="half_rhythm"><div class="half_rhythm"><b>What is selenium?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045113/" class="def">Selenium</a> is a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045787/" class="def">mineral</a> that is essential to humans in tiny amounts. Selenium is needed for many body functions, including reproduction and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000468803/" class="def">immunity</a>. Food sources of selenium include meat, vegetables, and nuts. The amount of selenium found in the food depends on the amount of selenium in the soil where the food grows. Selenium is stored in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044751/" class="def">thyroid gland</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046312/" class="def">liver</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046254/" class="def">pancreas</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046229/" class="def">pituitary gland</a>, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046325/" class="def">kidneys</a>.
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</div><div class="half_rhythm">Selenium may play a role in many diseases, including <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>. Results of the large <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044266/" class="def">National Cancer Institute</a>-sponsored Selenium and Vitamin E Cancer Prevention Trial (SELECT) suggest that men with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a> should not take selenium supplements.</div></li><li id="CDR0000719565__259" class="half_rhythm"><div class="half_rhythm"><b>How is selenium given or taken?</b></div><div class="half_rhythm">
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Selenium may be eaten in food or taken in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a>.
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</div></li><li id="CDR0000719565__261" class="half_rhythm"><div class="half_rhythm"><b>Have any laboratory or animal studies
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been done using selenium?</b></div><div class="half_rhythm">See the <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__294">Laboratory/Animal/Preclinical Studies</a> section of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a> done using selenium.
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</div></li><li id="CDR0000719565__263" class="half_rhythm"><div class="half_rhythm"><b>Have any studies of selenium been done in people?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000561718/" class="def">Population studies</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a> have been done to find out if selenium can <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevent</a> or treat prostate cancer. The results of these studies have been mixed, but the results of a large, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045858/" class="def">randomized clinical trial</a> showed selenium had no effect on the prevention of prostate cancer.<b>Combined studies</b><ul id="CDR0000719565__736"><li class="half_rhythm"><div>A review combined fifteen studies and found that <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a> selenium levels and levels of selenium measured in toenail clippings were linked to a decreased risk of prostate cancer.</div></li></ul></div><div class="half_rhythm"><b>Population studies</b><ul id="CDR0000719565__704"><li class="half_rhythm"><div>One study tracking men for up to 10 years found that those who had high levels of selenium in their blood had a lower risk of prostate cancer. However, a 2009 study found that men with high selenium levels were at greater risk of being <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnosed</a> with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046053/" class="def">aggressive</a> prostate cancer. These differences may be due to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046391/" class="def">genetic</a> factors.</div></li><li class="half_rhythm"><div>The Health Professionals Follow-Up Study included 4,459 men diagnosed with prostate cancer that had not spread to other parts of the body. The study found that taking selenium supplements after diagnosis may increase the risk of death from prostate cancer. The study investigators recommended that men with prostate cancer use caution in taking selenium supplements.</div></li></ul></div><div class="half_rhythm"><b>The Selenium and Vitamin E Cancer Prevention Trial (SELECT)</b></div><div class="half_rhythm"> The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a large clinical trial begun by the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044266/" class="def">National Cancer Institute</a> in 2001 to study the effects of selenium and/or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045023/" class="def">vitamin E</a> on the development of prostate cancer. Over 35,000 men, aged 50 years and older, were <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000322881/" class="def">randomly</a> assigned to receive one of the following combinations daily for 7 to 12 years:<ul id="CDR0000719565__349"><li class="half_rhythm"><div>Vitamin E and a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046688/" class="def">placebo</a>.</div></li><li class="half_rhythm"><div>Selenium and a placebo.</div></li><li class="half_rhythm"><div>Vitamin E and selenium.</div></li><li class="half_rhythm"><div>Two placebos.</div></li></ul></div><div class="half_rhythm">Early results of SELECT reported in 2009 found no difference in the rate of developing prostate cancer among the 4 groups. In the selenium alone group, there was a slight increase in the rate of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044129/" class="def">diabetes mellitus</a>. Even though this change was not clearly shown to be due to the supplement, the men in the study were advised to stop taking the study supplements. </div><div class="half_rhythm">Updated results of SELECT in 2011 showed that selenium supplements had no effect on prostate cancer risk.</div><div class="half_rhythm">In 2014, further results of SELECT showed that selenium supplements in men with low selenium levels at the start of the trial had no effect on the risk of developing prostate cancer risk. However, selenium supplements in men who had high levels of selenium at the start of the trial increased the risk of having aggressive prostate cancer.</div><div class="half_rhythm">A study of 1,434 men in SELECT suggested that changes in certain <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045693/" class="def">genes</a> which control the way selenium is used by the body may have an effect on the risk of developing prostate cancer.</div><div class="half_rhythm">Several factors may have affected study results, including the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044664/" class="def">dose</a> of vitamin E and the form of selenium used. The authors concluded that men should avoid selenium at doses that are higher than the recommended dietary intake.</div></li><li id="CDR0000719565__265" class="half_rhythm"><div class="half_rhythm"><b>Have any side effects or risks of selenium supplements been reported?</b></div><div class="half_rhythm">Selenium supplements have been well tolerated in many clinical trials. But, in the SELECT trial, the use of selenium supplements was linked with a slight increase in the rate of diabetes mellitus. </div><div class="half_rhythm">In several large studies, men with high selenium levels were at greater risk of being diagnosed with aggressive prostate cancer or dying from prostate cancer. </div></li><li id="CDR0000719565__267" class="half_rhythm"><div class="half_rhythm"><b>Is selenium approved by the U.S. Food and Drug Administration (FDA)
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for use as a cancer treatment in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of selenium supplements for the treatment or prevention of cancer.
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</div><div class="half_rhythm">Selenium is available in the United States in food products and dietary supplements. The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of selenium supplements may not be the same.</div></li></ol><div id="CDR0000719565__400"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_400_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__95"><h2 id="_CDR0000719565__95_">Questions and Answers About Soy</h2><ol id="CDR0000719565__96"><li id="CDR0000719565__97" class="half_rhythm"><div class="half_rhythm"><b>What is soy?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000415913/" class="def">soybean</a> plant has been grown in Asia for food for hundreds of years. The soybean can be made into products, such as soy milk, miso, tofu, soy flour, and oil. </div><div class="half_rhythm">Soy foods contain <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044709/" class="def">phytochemicals</a> that may have health benefits. <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046660/" class="def">Isoflavones</a> are the most widely studied <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000422394/" class="def">compounds</a> in soy. Major isoflavones in the soybean include <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046107/" class="def">genistein</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000285740/" class="def">daidzein</a>, and glycitein. </div><div class="half_rhythm">Isoflavones are <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000330175/" class="def">phytoestrogens</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046076/" class="def">estrogen</a>-like substances found in plants) that attach to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046409/" class="def">estrogen receptors</a> found in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a>. Genistein may affect some processes inside prostate cancer cells that are involved in the growth and spread of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>. </div></li><li id="CDR0000719565__99" class="half_rhythm"><div class="half_rhythm"><b>How is soy given or taken?</b></div><div class="half_rhythm">
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Soy may be eaten in food or taken in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a>.</div></li><li id="CDR0000719565__101" class="half_rhythm"><div class="half_rhythm"><b>Have any laboratory or animal studies
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been done using soy?</b></div><div class="half_rhythm">See the <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__110">Laboratory/Animal/Preclinical Studies</a> section of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a> done using soy.</div></li><li id="CDR0000719565__103" class="half_rhythm"><div class="half_rhythm"><b>Have any studies of soy been done in people?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000561718/" class="def">Population studies</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a> have been done to find out if soy can <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevent</a> or treat prostate cancer. The results of these studies have been mixed. Some studies have shown a lower risk of prostate cancer or a change in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046540/" class="def">prostate-specific antigen</a> (PSA) level, and others have not. The results may be mixed because the number of men participating in the studies is small and different types and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044664/" class="def">doses</a> of soy products were given for varying lengths of time.</div><div class="half_rhythm"><b>Combined population studies</b>
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<ul id="CDR0000719565__127"><li class="half_rhythm"><div>A 2018 review of many studies combined showed that men eating large amounts of nonfermented soy foods (for example, tofu and soybean milk) had a lower risk of prostate cancer. Eating large amounts of fermented foods (for example, miso) was not found to affect the risk of prostate cancer. However, these results may have been affected by the way the data were collected, the types of soy taken, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046391/" class="def">genetic</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045873/" class="def">risk factors</a>.</div></li></ul></div><div class="half_rhythm"><b>Clinical trials</b></div><div class="half_rhythm">Small <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045858/" class="def">randomized clinical trials</a> have been done to study the effects of isoflavones or soy on prostate cancer. The results of these studies have been mixed. See <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__704">Table 3</a>, <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__705">Table 4</a>, and <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__706">Table 5</a> of the health professional version of this summary for information on randomized, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044840/" class="def">placebo-controlled</a> clinical trials of isoflavones and soy.</div></li><li id="CDR0000719565__105" class="half_rhythm"><div class="half_rhythm"><b>Have any side effects or risks been reported from soy?</b></div><div class="half_rhythm">Soy products and isoflavones have been taken by prostate cancer patients with very few <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> in many clinical trials. The most commonly reported side effects were <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045692/" class="def">gastrointestinal</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>, such as <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000306496/" class="def">diarrhea</a>.
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</div></li><li id="CDR0000719565__107" class="half_rhythm"><div class="half_rhythm"><b>Is soy approved by the U.S. Food and Drug Administration (FDA)
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for use to prevent or treat cancer in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of soy as a treatment for cancer or any other medical <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a>.
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</div><div class="half_rhythm">Soy is available in the United States in food products and dietary supplements. The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of soy supplements may not be the same.</div></li></ol><div id="CDR0000719565__155"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_155_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__295"><h2 id="_CDR0000719565__295_">Questions and Answers About Vitamin D</h2><ol id="CDR0000719565__296"><li id="CDR0000719565__297" class="half_rhythm"><div class="half_rhythm"><b>What is vitamin D?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000427253/" class="def">Vitamin D</a> is a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000560348/" class="def">fat-soluble vitamin</a> found in fatty fish, fish liver oil, and eggs. Vitamin D may also be added to dairy products. </div><div class="half_rhythm">Vitamin D has many actions in the body, including the following:<ul id="CDR0000719565__370"><li class="half_rhythm"><div>Helps absorb <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045632/" class="def">calcium</a> from food in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046582/" class="def">small intestine</a>.</div></li><li class="half_rhythm"><div>Improves muscle strength and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046356/" class="def">immune system</a> function.</div></li><li class="half_rhythm"><div>Lowers <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044042/" class="def">inflammation</a>.</div></li><li class="half_rhythm"><div>Maintains levels of calcium and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476349/" class="def">phosphate</a> in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a>.</div></li><li class="half_rhythm"><div>Helps with bone growth and protects against <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045371/" class="def">osteoporosis</a> in adults.</div></li></ul></div><div class="half_rhythm">A person’s vitamin D level is usually checked by measuring the amount of 25-hydroxyvitamin D in the blood.</div></li><li id="CDR0000719565__300" class="half_rhythm"><div class="half_rhythm"><b>How is vitamin D given or taken?</b></div><div class="half_rhythm">Vitamin D is made naturally by the body when exposed to sunlight.
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Vitamin D may also be eaten in food or taken in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a>.
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</div></li><li id="CDR0000719565__301" class="half_rhythm"><div class="half_rhythm"><b>Have any laboratory or animal studies
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been done using vitamin D?</b></div><div class="half_rhythm">See the <a href="/books/n/pdqcis/CDR0000719335/#CDR0000719335__363">Laboratory/Animal/Preclinical Studies</a> section of the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a> for information on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044512/" class="def">laboratory</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454774/" class="def">animal studies</a> done using vitamin D.
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</div></li><li id="CDR0000719565__302" class="half_rhythm"><div class="half_rhythm"><b>Have any studies of vitamin D been done in people?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000561718/" class="def">Population studies</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a> have been done to study the effects of vitamin D on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a>. The results of these studies have been mixed. Some studies have shown a link between Vitamin D levels and prostate cancer, and others have not. There is not enough evidence to know whether giving vitamin D can <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevent</a> prostate cancer.</div><div class="half_rhythm"><b>Combined studies</b><ul id="CDR0000719565__716"><li class="half_rhythm"><div>A 2008 review of 45 studies found no link between taking vitamin D and prostate cancer risk.</div></li><li class="half_rhythm"><div>A 2009 study found that men with low levels of sun exposure had an increased risk of prostate cancer and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000478743/" class="def">advanced</a> disease.</div></li><li class="half_rhythm"><div>A 2011 review of 25 studies found no link between either vitamin D in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044660/" class="def">diet</a> or blood levels of vitamin D and the risk of prostate cancer.</div></li><li class="half_rhythm"><div>A 2014 review of 21 studies found that high levels of vitamin D may be linked with a higher risk of prostate cancer. Many factors may have affected this finding. It has been proposed that men from higher income groups may have higher vitamin D levels and are more likely to get <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651204/" class="def">PSA testing</a>, leading to higher rates of reported prostate cancer.</div></li></ul>
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</div><div class="half_rhythm"><b>Population studies</b><ul id="CDR0000719565__331"><li class="half_rhythm"><div>Vitamin D levels were checked every year for 5 years in men with prostate cancer that had not spread. Throughout the study, low levels of vitamin D were found in these men. </div></li><li class="half_rhythm"><div>Another study in men with prostate cancer suggested that medium or high levels of vitamin D in the blood may be linked with better <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000467853/" class="def">outcomes</a> than lower levels.</div></li><li class="half_rhythm"><div>One thousand men with prostate cancer and 1,000 men who did not have prostate cancer were followed for up to 20 years in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Results suggest that men with higher blood levels of vitamin D had a greater risk of developing prostate cancer than men with lower vitamin D levels.</div></li><li class="half_rhythm"><div>In an analysis from the Selenium and Vitamin E Cancer Prevention Trial (SELECT), men who had moderate blood levels of 25-hydroxyvitamin D were found to have a lower risk of having <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046053/" class="def">aggressive</a> prostate cancer than men who had either lower or higher levels of 25-hydroxyvitamin D.</div></li><li class="half_rhythm"><div>A study of patterns of deaths in the United States from 1950 to 1994 showed that higher death rates from prostate cancer occurred in parts of the country with lower levels of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044472/" class="def">UV radiation</a> from sunlight. </div></li></ul></div><div class="half_rhythm"><b>Clinical trials</b><ul id="CDR0000719565__338"><li class="half_rhythm"><div>In a 2018 <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045858/" class="def">randomized</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044014/" class="def">controlled trial</a>, vitamin D3 and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045809/" class="def">omega-3 fatty acid</a> supplements were given to prevent <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000748137/" class="def">cardiovascular disease</a>. Those who took the vitamin D supplement did not have a lower rate of any cancer, including prostate cancer.</div></li><li class="half_rhythm"><div>A clinical trial treated patients with prostate cancer that had <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurred</a> (come back) with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045408/" class="def">calcitriol</a> (the active form of vitamin D) and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000615394/" class="def">naproxen</a> for 1 year. Results showed that after taking calcitriol and naproxen the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046540/" class="def">prostate-specific antigen</a> (PSA) level rose more slowly.</div></li><li class="half_rhythm"><div> In a 2010 study, patients with prostate cancer that did not <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">respond</a> to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045110/" class="def">hormone therapy</a> were treated with calcitriol and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045262/" class="def">dexamethasone</a>. The results showed no effect on PSA levels.</div></li><li class="half_rhythm"><div>In a 2009 study, patients with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045955/" class="def">locally advanced</a> or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044058/" class="def">metastatic</a> prostate cancer were treated with vitamin D. The study reported that 1 in every 5 patients who took vitamin D had lower PSA levels.</div></li></ul></div></li><li id="CDR0000719565__472" class="half_rhythm"><div class="half_rhythm"><b>Have any side effects or risks been reported from vitamin D? </b></div><div class="half_rhythm">Vitamin D can cause serious health problems when taken at high <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044664/" class="def">doses</a> over many years. Taking high levels of Vitamin D can cause too much calcium to be absorbed in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046335/" class="def">intestines</a>, leading to rapid increases in blood calcium levels. This <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a> is called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045363/" class="def">hypercalcemia</a>.</div><div class="half_rhythm">In a group of 26 studies, Vitamin D was reviewed for safety, how well it works, and whether it <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454754/" class="def">interacts</a> with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000348921/" class="def">drugs</a> used to treat prostate cancer and other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumors</a>. The reviewers found the risk of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> and interactions with other drugs to be low.</div><div class="half_rhythm"> Several studies looked at the safety of high-dose vitamin D and how well it works with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">chemotherapy</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045382/" class="def">docetaxel</a>) to treat men with prostate cancer that did not respond to hormone therapy. The side effects that occurred after treatment with high-dose vitamin D and docetaxel were the same as the side effects noted after treatment with docetaxel alone. </div></li><li id="CDR0000719565__304" class="half_rhythm"><div class="half_rhythm"><b>Is vitamin D approved by the U.S. Food and Drug Administration (FDA)
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for use as a cancer treatment in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of vitamin D as a treatment for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>.</div><div class="half_rhythm">Vitamin D is available in the United States in food products and dietary supplements. The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of vitamin D supplements may not be the same.</div></li></ol><div id="CDR0000719565__403"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_403_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__269"><h2 id="_CDR0000719565__269_">Questions and Answers About Vitamin E</h2><ol id="CDR0000719565__270"><li id="CDR0000719565__271" class="half_rhythm"><div class="half_rhythm"><b>What is vitamin E?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045023/" class="def">Vitamin E</a> is an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000043997/" class="def">antioxidant</a> that may help protect <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> from damage. Vitamin E also affects how signals are sent within cells and how the cell makes <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046568/" class="def">RNA</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046092/" class="def">proteins</a>. </div><div class="half_rhythm">There are eight forms of vitamin E: four tocopherols (alpha-, beta-, gamma-, and sigma-) and four tocotrienols (alpha-, beta-, gamma-, and sigma-). <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000691423/" class="def">Alpha-tocopherol</a>, the form of vitamin E used in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplements</a>, is found in greater amounts in the body and is the most active form of vitamin E. Most vitamin E in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044660/" class="def">diet</a> comes from gamma-tocopherol. Food sources of vitamin E include vegetable oils, nuts, and egg yolks.
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</div><div class="half_rhythm"> Vitamin E may protect against <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045641/" class="def">chronic diseases</a>, such as <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000748138/" class="def">heart</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045020/" class="def">blood vessel</a> disease. </div></li><li id="CDR0000719565__276" class="half_rhythm"><div class="half_rhythm"><b>How is vitamin E given or taken?</b></div><div class="half_rhythm">
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Vitamin E may be eaten in food or taken in dietary supplements.
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</div></li><li id="CDR0000719565__284" class="half_rhythm"><div class="half_rhythm"><b>Have any studies of vitamin E been done in people?</b></div><div class="half_rhythm"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000561718/" class="def">Population studies</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a> have been done to find out if vitamin E may <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevent</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a>. The results of these studies have been mixed; some studies have shown no change in the overall risk of prostate cancer, and others have shown an increased risk of prostate cancer. There is not enough evidence to know whether vitamin E affects the risk of prostate cancer.</div><div class="half_rhythm"><b>Combined population studies</b><ul id="CDR0000719565__718"><li class="half_rhythm"><div>In a review of combined studies with about 370,000 men from several countries, higher <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a> levels of alpha-tocopherol were linked with a lower risk of prostate cancer.</div></li></ul>
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</div><div class="half_rhythm"><b>Population studies</b><ul id="CDR0000719565__391"><li class="half_rhythm"><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044268/" class="def">National Institutes of Health</a>–American Association of Retired Persons (NIH-AARP) Diet and Healthy Study studied whether taking increased amounts of vitamin E in the diet and in dietary supplements could prevent prostate cancer. After 5 years, no link between vitamin E supplements and prostate cancer risk was found. However, a lower risk of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000478743/" class="def">advanced</a> prostate cancer was found in men who took high amounts of gamma-tocopherol. </div></li><li class="half_rhythm"><div class="half_rhythm">In a 2010 study that measured blood levels of vitamin E, the men who had prostate cancer had lower blood levels of vitamin E than those who did not have prostate cancer. In addition, those who had higher <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044867/" class="def">PSA</a> levels had lower levels of vitamin E in their blood.</div></li><li class="half_rhythm"><div class="half_rhythm">The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study (ATBC) trial measured blood levels of alpha-tocopherol and dietary intake of vitamin E in men who were followed for up to 19 years. Results showed no link between vitamin E in the diet and prostate cancer risk. However, higher levels of alpha-tocopherol in the blood may be linked with a lower risk for developing advanced prostate cancer. </div><div class="half_rhythm">Men in the ATBC trial who developed prostate cancer were studied to find out if blood levels of alpha-tocopherol affected survival time. Higher blood levels of alpha-tocopherol, at both time of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnosis</a> and at the 3-year time point, were linked with improved prostate cancer survival.</div></li></ul>
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</div><div class="half_rhythm"><b>The Selenium and Vitamin E Cancer Prevention Trial (SELECT)</b></div><div class="half_rhythm"> The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a large clinical trial to study the effects of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045113/" class="def">selenium</a> and/or vitamin E on the development of prostate cancer. Over 35,000 men, aged 50 years and older, were randomly assigned to receive one of the following combinations daily for 7 to12 years:<ul id="CDR0000719565__353"><li class="half_rhythm"><div>Vitamin E and a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046688/" class="def">placebo</a>.</div></li><li class="half_rhythm"><div>Selenium and a placebo.</div></li><li class="half_rhythm"><div>Vitamin E and selenium.</div></li><li class="half_rhythm"><div>Two placebos.</div></li></ul></div><div class="half_rhythm">SELECT results published in 2011 showed that men taking vitamin E alone had a 17% increase in prostate cancer risk compared with men who did not take vitamin E.</div><div class="half_rhythm"> Several factors may have affected study results, including the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044664/" class="def">dose</a> of vitamin E.</div><div class="half_rhythm"><b>Clinical trials</b><ul id="CDR0000719565__721"><li class="half_rhythm"><div>In the Physicians’ Health Study II, men took either vitamin E supplements, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439435/" class="def">vitamin C</a> supplements, or both and were followed for about 8 years. The overall rates of prostate cancer were similar in the men who took vitamin E supplements and in those who did not. Vitamin E did not affect the number of new cases of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> or the number of deaths from cancer.</div></li><li class="half_rhythm"><div>A 2011 study of men who took part in The Carotene and Retinol Efficacy Trial (CARET) found that, among those who were current smokers, higher blood levels of alpha-tocopherols and gamma-tocopherols were linked with lower risk of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046053/" class="def">aggressive</a> prostate cancer. In another study of men who were current smokers or who recently stopped smoking, higher blood levels of alpha-tocopherol were linked to a lower risk of prostate cancer.</div></li></ul></div></li><li id="CDR0000719565__286" class="half_rhythm"><div class="half_rhythm"><b>Have any side effects or risks been reported from vitamin E?</b></div><div class="half_rhythm">In the Physicians’ Health Study II and the Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group, there was a higher number of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439425/" class="def">strokes</a> caused by a broken blood vessel in the brain in men who took vitamin E than in men who took a placebo.
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</div></li><li id="CDR0000719565__288" class="half_rhythm"><div class="half_rhythm"><b>Is vitamin E approved by the U.S. Food and Drug Administration (FDA)
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for use as a cancer treatment in the United States?</b></div><div class="half_rhythm">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454785/" class="def">U.S. Food and Drug Administration</a> has not approved the use of vitamin E as a treatment for cancer.</div><div class="half_rhythm">Alpha-tocopherols are deemed Generally Recognized as Safe by the FDA.</div><div class="half_rhythm">Vitamin E is available in the United States in food products and dietary supplements. The FDA does not approve dietary supplements as safe or effective. The company that makes the dietary supplements is responsible for making sure that they are safe and that the claims on the label are true and do not mislead the consumer. The way that supplements are made is not regulated by the FDA, so all batches and brands of vitamin E supplements may not be the same.</div></li></ol><div id="CDR0000719565__406"><h3>Current Clinical Trials</h3><p id="CDR0000719565__TrialSearch_406_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000719565__447"><h2 id="_CDR0000719565__447_">Combination Therapies</h2><div id="CDR0000719565__448"><h3>Pomi-T (Pomegranate, Green Tea, Broccoli, and Turmeric)</h3><p id="CDR0000719565__466"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000256573/" class="def">Polyphenols</a> are found in many plants and give some flowers, fruits, and vegetables their color. Polyphenols have <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000043997/" class="def">antioxidant</a> activity that may help protect <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> from damage. </p><p id="CDR0000719565__449">A food <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045916/" class="def">supplement</a> that is high in polyphenols was studied in a group of men who had <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a> that had not spread. This supplement contained the following:</p><ul id="CDR0000719565__467"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000321386/" class="def">Pomegranate</a> whole fruit powder.</div></li><li class="half_rhythm"><div>Broccoli powder.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000463050/" class="def">Turmeric</a> powder.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000389271/" class="def">Green tea extract</a>.</div></li></ul><p id="CDR0000719565__463">One hundred and ninety-nine men were randomly assigned to receive either the food supplement or a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046688/" class="def">placebo</a> for 6 months. The food supplement was well tolerated. However, men in the supplement group were more likely to have <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045692/" class="def">gastrointestinal</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>, such as gassiness and loose bowels.</p></div><div id="CDR0000719565__660"><h3>Lycopene, Selenium, and Green Tea</h3><p id="CDR0000719565__668">A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373932/" class="def">dietary supplement</a> was studied in 60 men at high risk of prostate cancer (high-grade <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044345/" class="def">prostatic intraepithelial neoplasia</a>). The supplement contained the following:</p><ul id="CDR0000719565__732"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044909/" class="def">Lycopene</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045113/" class="def">Selenium</a>.</div></li><li class="half_rhythm"><div>Green tea <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000686469/" class="def">catechins</a>.</div></li></ul><p id="CDR0000719565__733">The men were <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000322881/" class="def">randomly</a> assigned to receive the supplement or a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046688/" class="def">placebo</a>. Men who took the supplement for 6 months had higher rates of prostate cancer when they had a repeat <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045164/" class="def">biopsy</a> than men who did not take the supplement. This result may be due to cancers missed at the start of the study. </p></div><div id="CDR0000719565__665"><h3>Lycopene and Other Therapies</h3><p id="CDR0000719565__669">A study enrolled 79 men who were scheduled to have a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045851/" class="def">prostatectomy</a>. For 3 weeks before <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a>, the men were assigned to eat or drink either: </p><ul id="CDR0000719565__737"><li class="half_rhythm"><div>Tomato products containing lycopene;</div></li><li class="half_rhythm"><div>Tomato products plus selenium, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045809/" class="def">omega 3-fatty acids</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000407766/" class="def">soy</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046660/" class="def">isoflavones</a>, grape/<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000321386/" class="def">pomegranate</a> juice, and green/black tea; or</div></li><li class="half_rhythm"><div>A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044660/" class="def">diet</a> without added <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044697/" class="def">nutrients</a>.</div></li></ul><p id="CDR0000719565__735">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046540/" class="def">prostate-specific antigen</a> (PSA) levels were the same for men who received added nutrients and those who did not. However, among men with intermediate-risk prostate cancer, lower PSA levels were found in those who ate the tomato products or had the highest increases in lycopene levels.</p></div><div id="CDR0000719565__161"><h3>Zyflamend</h3><p id="CDR0000719565__726">Zyflamend is a dietary supplement that contains <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000407760/" class="def">extracts</a> of 10 different <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000463714/" class="def">herbs</a> in olive oil:</p><ul id="CDR0000719565__727"><li class="half_rhythm"><div>Rosemary.</div></li><li class="half_rhythm"><div>Turmeric.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000340930/" class="def">Ginger</a>.</div></li><li class="half_rhythm"><div>Holy basil.</div></li><li class="half_rhythm"><div>Green tea.</div></li><li class="half_rhythm"><div>Hu zhang (<i>Polygonum cuspidatum</i>).</div></li><li class="half_rhythm"><div>Chinese goldthread.</div></li><li class="half_rhythm"><div>Barberry.</div></li><li class="half_rhythm"><div>Oregano.</div></li><li class="half_rhythm"><div>Baikal skullcap.</div></li></ul><p id="CDR0000719565__728">The herb extracts used in Zyflamend may have <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044187/" class="def">anti-inflammatory</a> activity. There is not enough evidence to know whether Zyflamend can <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000439419/" class="def">prevent</a> or treat prostate cancer.</p><p id="CDR0000719565__729">Zyflamend is taken as a dietary supplement in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000455334/" class="def">capsule</a> form.</p><p id="CDR0000719565__731">No serious <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> have been reported for Zyflamend. In one study, some of the participants had mild heartburn that went away when Zyflamend was taken with food.</p></div></div><div id="CDR0000719565__347"><h2 id="_CDR0000719565__347_">Other Prostate Health Supplements</h2><div id="CDR0000719565__356"><h3>Overview</h3><p id="CDR0000719565__357">African Cherry (<i>pygeum africanum</i>) and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000773858/" class="def">beta-sitosterol</a> are two supplements that have been studied for general <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046539/" class="def">prostate</a> health and the treatment of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046509/" class="def">benign prostatic hyperplasia</a> (BPH) and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000445079/" class="def">prostate cancer</a>. For more information about African Cherry (<i>pygeum africanum</i>) and beta-sitosterol, see the health professional version of <a href="/books/n/pdqcis/CDR0000719335/">Prostate Cancer, Nutrition, and Dietary Supplements</a>. </p></div></div><div id="CDR0000719565__AboutThis_1"><h2 id="_CDR0000719565__AboutThis_1_">About This PDQ Summary</h2><div id="CDR0000719565__AboutThis_2"><h3>About PDQ</h3><p id="CDR0000719565__AboutThis_3">Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in <a href="https://www.cancer.gov/espanol/publicaciones/pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Spanish</a>.</p><p id="CDR0000719565__AboutThis_4">PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.</p></div><div id="CDR0000719565__AboutThis_5"><h3>Purpose of This Summary</h3><p id="CDR0000719565__AboutThis_6">This PDQ cancer information summary has current information about the use of nutrition and dietary supplements for reducing the risk of developing prostate cancer or for treating prostate cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p></div><div id="CDR0000719565__AboutThis_7"><h3>Reviewers and Updates</h3><p id="CDR0000719565__AboutThis_8">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change.
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</p><p id="CDR0000719565__AboutThis_9">The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the <a href="https://www.cancer.gov/publications/pdq/editorial-boards/cam" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PDQ Integrative, Alternative, and Complementary Therapies Editorial Board</a>.
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</p></div><div id="CDR0000719565__AboutThis_10"><h3>Clinical Trial Information</h3><p id="CDR0000719565__AboutThis_11">A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
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</p><p id="CDR0000719565__AboutThis_12">Clinical trials can be found online at <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCI's website</a>. For more information, call the <a href="https://www.cancer.gov/contact/contact-center" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cancer Information Service</a> (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237).
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</p></div><div id="CDR0000719565__AboutThis_13"><h3>Permission to Use This Summary</h3><p id="CDR0000719565__AboutThis_14">PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”
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</p><p id="CDR0000719565__AboutThis_15">The best way to cite this PDQ summary is:</p><p id="CDR0000719565__AboutThis_21">PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Prostate Cancer, Nutrition, and Dietary Supplements. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: <a href="https://www.cancer.gov/about-cancer/treatment/cam/patient/prostate-supplements-pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www.cancer.gov/about-cancer/treatment/cam/patient/prostate-supplements-pdq</a>. Accessed <MM/DD/YYYY>. [PMID: 26389501]</p><p id="CDR0000719565__AboutThis_16">Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in <a href="https://visualsonline.cancer.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Visuals Online</a>. Visuals Online is a collection of more than 3,000 scientific images.
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</p></div><div id="CDR0000719565__AboutThis_17"><h3>Disclaimer</h3><p id="CDR0000719565__AboutThis_18">The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the <a href="https://www.cancer.gov/about-cancer/managing-care" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Managing Cancer Care</a> page.</p></div><div id="CDR0000719565__AboutThis_19"><h3>Contact Us</h3><p id="CDR0000719565__AboutThis_20">More information about contacting us or receiving help with the Cancer.gov website can be found on our <a href="https://www.cancer.gov/contact" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Contact Us for Help</a> page. Questions can also be submitted to Cancer.gov through the website’s <a href="https://www.cancer.gov/contact/email-us" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">E-mail Us</a>.</p></div></div><div id="CDR0000719565__AboutIACT_2"><h2 id="_CDR0000719565__AboutIACT_2_">General CAM Information</h2><p id="CDR0000719565__AboutIACT_3">Complementary and alternative medicine (CAM)—also called integrative medicine—includes a broad range of healing philosophies, approaches, and therapies. A therapy is generally called complementary when it is used in addition to conventional treatments; it is often called alternative when it is used instead of conventional treatment. (Conventional treatments are those that are widely accepted and practiced by the mainstream medical community.) Depending on how they are used, some therapies can be considered either complementary or alternative. Complementary and alternative therapies are used in an effort to prevent illness, reduce stress, prevent or reduce side effects and symptoms, or control or cure disease. </p><p id="CDR0000719565__AboutIACT_4">Unlike conventional treatments for cancer, complementary and alternative therapies are often not covered by insurance companies. Patients should check with their insurance provider to find out about coverage for complementary and alternative therapies. </p><p id="CDR0000719565__AboutIACT_5">Cancer patients considering complementary and alternative therapies should discuss this decision with their doctor, nurse, or pharmacist as they would any type of treatment. Some complementary and alternative therapies may affect their standard treatment or may be harmful when used with conventional treatment. </p></div><div id="CDR0000719565__AboutIACT_6"><h2 id="_CDR0000719565__AboutIACT_6_">Evaluation of CAM Therapies</h2><p id="CDR0000719565__AboutIACT_7">It is important that the same scientific methods used to test conventional therapies are used to test CAM therapies. The National Cancer Institute and the National Center for Complementary and Integrative Health (NCCIH) are sponsoring a number of clinical trials (research studies) at medical centers to test CAM therapies for use in cancer. </p><p id="CDR0000719565__AboutIACT_8">Conventional approaches to cancer treatment have generally been studied for safety and effectiveness through a scientific process that includes clinical trials with large numbers of patients. Less is known about the safety and effectiveness of complementary and alternative methods. Few CAM therapies have been tested using demanding scientific methods. A small number of CAM therapies that were thought to be purely alternative approaches are now being used in cancer treatment—not as cures, but as complementary therapies that may help patients feel better and recover faster. One example is acupuncture. According to a panel of experts at a National Institutes of Health (NIH) meeting in November 1997, acupuncture has been found to help control nausea and vomiting caused by chemotherapy and pain related to surgery. However, some approaches, such as the use of laetrile, have been studied and found not to work and to possibly cause harm.</p><p id="CDR0000719565__AboutIACT_9"><a href="https://cam.cancer.gov/indentifying_novel_cam_therapies/best_case_series_program.htm" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">The NCI Best Case Series Program</a> which was started in 1991, is one way CAM approaches that are being used in practice are being studied. The program is overseen by the NCI’s Office of Cancer Complementary and Alternative Medicine (OCCAM). Health care professionals who offer alternative cancer therapies submit their patients’ medical records and related materials to OCCAM. OCCAM carefully reviews these materials to see if any seem worth further research.</p></div><div id="CDR0000719565__QandA_2"><h2 id="_CDR0000719565__QandA_2_">Questions to Ask Your Health Care Provider About CAM</h2><p id="CDR0000719565__QandA_3">When considering complementary and alternative therapies, patients should ask their health care provider the following questions: </p><ul id="CDR0000719565__QandA_4"><li class="half_rhythm"><div>What side effects can be expected?</div></li><li class="half_rhythm"><div>What are the risks related to this therapy?</div></li><li class="half_rhythm"><div>What benefits can be expected from this therapy?</div></li><li class="half_rhythm"><div>Do the known benefits outweigh the risks?</div></li><li class="half_rhythm"><div>Will the therapy affect conventional treatment?</div></li><li class="half_rhythm"><div>Is this therapy part of a clinical trial?</div></li><li class="half_rhythm"><div>If so, who is the sponsor of the trial?</div></li><li class="half_rhythm"><div>Will the therapy be covered by health insurance?</div></li></ul></div><div id="CDR0000719565__ToLearnMore_2"><h2 id="_CDR0000719565__ToLearnMore_2_">To Learn More About CAM</h2><p id="CDR0000719565__ToLearnMore_3"><b><i>National Center for Complementary and Integrative Health (NCCIH)</i></b></p><p id="CDR0000719565__ToLearnMore_4">The National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health (NIH) facilitates research and evaluation of complementary and alternative practices, and provides information about a variety of approaches to health professionals and the public.</p><ul id="CDR0000719565__ToLearnMore_5" class="simple-list"><li class="half_rhythm"><div>NCCIH Clearinghouse</div></li><li class="half_rhythm"><div>Post Office Box 7923 Gaithersburg, MD 20898–7923</div></li><li class="half_rhythm"><div>Telephone: 1-888-644-6226 (toll free)</div></li><li class="half_rhythm"><div>TTY (for deaf and hard of hearing callers): 1-866-464-3615</div></li><li class="half_rhythm"><div>E-mail: info@nccih.nih.gov</div></li><li class="half_rhythm"><div>Website: <a href="https://nccih.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://nccih.nih.gov</a></div></li></ul><p id="CDR0000719565__ToLearnMore_15"><b><i>CAM on PubMed</i></b></p><p id="CDR0000719565__ToLearnMore_16">NCCIH and the NIH National Library of Medicine (NLM) jointly developed <a href="https://nccih.nih.gov/research/camonpubmed" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">CAM on PubMed</a>, a free and easy-to-use search tool for finding CAM-related journal citations. As a subset of the NLM's PubMed bibliographic database, CAM on PubMed features more than 230,000 references and abstracts for CAM-related articles from scientific journals. This database also provides links to the websites of over 1,800 journals, allowing users to view full-text articles. (A subscription or other fee may be required to access full-text articles.) </p><p id="CDR0000719565__ToLearnMore_17"><b><i>Office of Cancer Complementary and Alternative Medicine</i></b></p><p id="CDR0000719565__ToLearnMore_18">The NCI Office of Cancer Complementary and Alternative Medicine (OCCAM) coordinates the activities of the NCI in the area of complementary and alternative medicine (CAM). OCCAM supports CAM cancer research and provides information about cancer-related CAM to health providers and the general public via the <a href="https://www.cancer.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCI website</a>. </p><p id="CDR0000719565__ToLearnMore_19"><b><i>National Cancer Institute (NCI) Cancer Information Service</i></b></p><p id="CDR0000719565__ToLearnMore_20">U.S. residents may call the <a href="https://www.cancer.gov/contact/contact-center" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cancer Information Service</a> (CIS), NCI's contact center, toll free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 9:00 am to 9:00 pm. A trained Cancer Information Specialist is available to answer your questions.</p><p id="CDR0000719565__ToLearnMore_8"><b><i>Food and Drug Administration </i></b></p><p id="CDR0000719565__ToLearnMore_9">The Food and Drug Administration (FDA) regulates drugs and medical devices to ensure that they are safe and effective.</p><ul id="CDR0000719565__ToLearnMore_10" class="simple-list"><li class="half_rhythm"><div>Food and Drug Administration </div></li><li class="half_rhythm"><div>10903 New Hampshire Avenue</div></li><li class="half_rhythm"><div>Silver Spring, MD 20993</div></li><li class="half_rhythm"><div>Telephone: 1-888-463-6332 (toll free)</div></li><li class="half_rhythm"><div>Website: <a href="https://www.fda.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.fda.gov</a></div></li></ul><p id="CDR0000719565__ToLearnMore_11"><b><i>Federal Trade Commission </i></b></p><p id="CDR0000719565__ToLearnMore_12">The Federal Trade Commission (FTC) enforces consumer protection laws. Publications available from the FTC include: </p><ul id="CDR0000719565__ToLearnMore_13"><li class="half_rhythm"><div><i>Who Cares: Sources of Information About Health Care Products and Services </i></div></li><li class="half_rhythm"><div><i>Fraudulent Health Claims: Don’t Be Fooled </i></div></li></ul><ul id="CDR0000719565__ToLearnMore_14" class="simple-list"><li class="half_rhythm"><div>Consumer Response Center</div></li><li class="half_rhythm"><div>Federal Trade Commission</div></li><li class="half_rhythm"><div>600 Pennsylvania Avenue, NW</div></li><li class="half_rhythm"><div>Washington, DC 20580</div></li><li class="half_rhythm"><div>Telephone: 1-877-FTC-HELP (1-877-382-4357) (toll free)</div></li><li class="half_rhythm"><div>TTY (for deaf and hard of hearing callers): 202-326-2502</div></li><li class="half_rhythm"><div>Website: <a href="https://www.ftc.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.ftc.gov</a></div></li></ul></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK83984.21/?report=reader">PubReader</a></li><li><a href="/books/NBK83984.21/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK83984" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK83984" style="display:none" title="Cite this Page"><div class="bk_tt">PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Prostate Cancer, Nutrition, and Dietary Supplements (PDQ®): Patient Version. 2021 Jun 17. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. <span class="bk_cite_avail"></span></div></div></li><li><a href="#" class="toggle-glossary-link" title="Enable/disable links to the glossary">Disable Glossary Links</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Version History</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter shutter_closed" title="Show/hide content" remembercollapsed="true" pgsec_name="version_history" id="Shutter"></a></div><div class="portlet_content" style="display: none;"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><span class="bk_col_itm"><a href="/books/NBK83984.24/">NBK83984.24</a></span> May 8, 2024</li><li><span class="bk_col_itm"><a href="/books/NBK83984.23/">NBK83984.23</a></span> May 11, 2022</li><li><span class="bk_col_itm"><a href="/books/NBK83984.22/">NBK83984.22</a></span> 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href="/books/NBK83984.2/">NBK83984.2</a></span> September 18, 2015</li><li><span class="bk_col_itm"><a href="/books/NBK83984.1/">NBK83984.1</a></span> September 2, 2015</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this Page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#CDR0000719565__1" ref="log$=inpage&link_id=inpage">Introduction</a></li><li><a href="#CDR0000719565__56" ref="log$=inpage&link_id=inpage">Overview of CAM Use in Prostate Cancer</a></li><li><a href="#CDR0000719565__446" ref="log$=inpage&link_id=inpage">Questions and Answers About Calcium</a></li><li><a href="#CDR0000719565__175" ref="log$=inpage&link_id=inpage">Questions and Answers About Green Tea</a></li><li><a href="#CDR0000719565__3" ref="log$=inpage&link_id=inpage">Questions and Answers About Lycopene</a></li><li><a href="#CDR0000719565__61" ref="log$=inpage&link_id=inpage">Questions and Answers About Modified Citrus Pectin</a></li><li><a href="#CDR0000719565__79" ref="log$=inpage&link_id=inpage">Questions and Answers About Pomegranate</a></li><li><a href="#CDR0000719565__250" ref="log$=inpage&link_id=inpage">Questions and Answers About Selenium</a></li><li><a href="#CDR0000719565__95" ref="log$=inpage&link_id=inpage">Questions and Answers About Soy</a></li><li><a href="#CDR0000719565__295" ref="log$=inpage&link_id=inpage">Questions and Answers About Vitamin D</a></li><li><a href="#CDR0000719565__269" ref="log$=inpage&link_id=inpage">Questions and Answers About Vitamin E</a></li><li><a href="#CDR0000719565__447" ref="log$=inpage&link_id=inpage">Combination Therapies</a></li><li><a href="#CDR0000719565__347" ref="log$=inpage&link_id=inpage">Other Prostate Health Supplements</a></li><li><a href="#CDR0000719565__AboutThis_1" ref="log$=inpage&link_id=inpage">About This PDQ Summary</a></li><li><a href="#CDR0000719565__AboutIACT_2" ref="log$=inpage&link_id=inpage">General CAM Information</a></li><li><a href="#CDR0000719565__AboutIACT_6" ref="log$=inpage&link_id=inpage">Evaluation of CAM Therapies</a></li><li><a href="#CDR0000719565__QandA_2" ref="log$=inpage&link_id=inpage">Questions to Ask Your Health Care Provider About CAM</a></li><li><a href="#CDR0000719565__ToLearnMore_2" ref="log$=inpage&link_id=inpage">To Learn More About CAM</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related publications</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" id="Shutter"></a></div><div class="portlet_content"><ul 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<title>Youtube</title>
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<style type="text/css">
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<path class="st5" d="M88.4,1037.4c-10.4,0-18.7,8.3-18.7,18.7v40.1c0,10.4,8.3,18.7,18.7,18.7h72.1c10.4,0,18.7-8.3,18.7-18.7 v-40.1c0-10.4-8.3-18.7-18.7-18.7H88.4z M115.2,1058.8l29.4,17.4l-29.4,17.4V1058.8z"></path>
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<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
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Bethesda, MD 20894</a></p>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
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<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
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<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
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<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
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<a class="text-white" href="https://www.nih.gov/">NIH</a>
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