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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="PDQ Cancer Information Summaries [Internet]" /><meta name="citation_title" content="Liver (Hepatocellular) Cancer Screening (PDQ®)" /><meta name="citation_publisher" content="National Cancer Institute (US)" /><meta name="citation_date" content="2007/12/27" /><meta name="citation_author" content="PDQ Screening and Prevention Editorial Board" /><meta name="citation_pmid" content="26389386" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK65948/" /><meta name="citation_keywords" content="liver and intrahepatic biliary tract cancer" /><meta name="citation_keywords" content="disease screening" /><meta name="citation_keywords" content="liver and intrahepatic biliary tract cancer" /><meta name="citation_keywords" content="disease screening" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Liver (Hepatocellular) Cancer Screening (PDQ®)" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Cancer Institute (US)" /><meta name="DC.Contributor" content="PDQ Screening and Prevention Editorial Board" /><meta name="DC.Date" content="2007/12/27" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK65948/" /><meta name="description" content="Liver (hepatocellular) cancer screening is not currently recommended as a routine part of cancer screening. Not all screening tests are helpful, and many have risks. Learn more about liver cancer and the tests used to detect it in this expert-reviewed summary." /><meta name="og:title" content="Liver (Hepatocellular) Cancer Screening (PDQ®)" /><meta name="og:type" content="book" /><meta name="og:description" content="Liver (hepatocellular) cancer screening is not currently recommended as a routine part of cancer screening. Not all screening tests are helpful, and many have risks. Learn more about liver cancer and the tests used to detect it in this expert-reviewed summary." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK65948/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/pdqcis/CDR0000569404/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK65948/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/pdqcis/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" alt="Cover of PDQ Cancer Information Summaries" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>PDQ Cancer Information Summaries [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK65948_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK65948_dtls__"><div>Bethesda (MD): <a href="http://www.cancer.gov/" ref="pagearea=page-banner&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher">National Cancer Institute (US)</a>; 2002-.</div></div><div class="half_rhythm"></div><div class="bk_noprnt"><form method="get" action="/books/n/pdqcis/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div></div>
<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK65948_"><span class="title" itemprop="name">Liver (Hepatocellular) Cancer Screening (PDQ&#x000ae;)</span></h1><div class="subtitle whole_rhythm">Patient Version</div><p class="contrib-group"><span itemprop="author">PDQ Screening and Prevention Editorial Board</span>.</p><p class="small">Published online: August 5, 2020.</p><p class="small">Created: <span itemprop="datePublished">December 27, 2007</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><p id="CDR0000569404__76">This PDQ cancer information summary has current information about liver (hepatocellular) cancer screening. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p><p id="CDR0000569404__77">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change. The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Screening and Prevention Editorial Board.</p></div><div id="CDR0000569404__1"><h2 id="_CDR0000569404__1_">What is screening?</h2><p id="CDR0000569404__2"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046171/" class="def">Screening</a> is looking for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> before a person has any <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>. This can help find cancer at an early <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045885/" class="def">stage</a>. When <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044636/" class="def">abnormal</a>
<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a> or cancer is found early, it may be easier to treat. By the time symptoms appear, cancer may have begun to spread.</p><p id="CDR0000569404__3"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044724/" class="def">Scientists</a> are trying to better understand which people are more likely to get certain types of cancer. They also study the things we do and the things around us to see if they cause cancer. This information helps doctors recommend who should be screened for cancer, which screening tests should be used, and how often the tests should be done.</p><p id="CDR0000569404__4">It is important to remember that your doctor does not necessarily think you have cancer if he or she suggests a screening test. Screening tests are given when you have no cancer symptoms.</p><p id="CDR0000569404__5">If a screening test result is abnormal, you may need to have more tests done to find out if you have cancer. These are called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045959/" class="def">diagnostic tests</a>.</p></div><div id="CDR0000569404__8"><h2 id="_CDR0000569404__8_">General Information About Liver (Hepatocellular) Cancer</h2><div id="CDR0000569404__8.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000569404__9">Liver cancer is a disease in which malignant (cancer) cells form in the tissues of the liver.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000569404__13">Liver cancer is less common in the United States than in other parts of the world.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000569404__16">Having hepatitis or cirrhosis can increase the risk of developing liver cancer.</a></div></li></ul></div><div id="CDR0000569404__9"><h3>Liver cancer is a disease in which malignant (cancer) cells form in the tissues of the liver.</h3><p id="CDR0000569404__11">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046312/" class="def">liver</a> is one of the largest <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000257523/" class="def">organs</a> in the body. It has two <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046188/" class="def">lobes</a> and fills the upper right side of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045070/" class="def">abdomen</a> inside the rib cage. Three of the many important functions of the liver are:</p><ul id="CDR0000569404__12"><li class="half_rhythm"><div>To filter harmful substances from the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a> so they can be passed from the body in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046605/" class="def">stools</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046642/" class="def">urine</a>.</div></li><li class="half_rhythm"><div>To make <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046508/" class="def">bile</a> to help <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000463707/" class="def">digest</a> fats from food.</div></li><li class="half_rhythm"><div>To store glycogen (sugar), which the body uses for energy.</div></li></ul><div id="CDR0000569404__75" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Anatomy%20of%20the%20liver&amp;p=BOOKS&amp;id=560418_CDR0000658698.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK65948.4/bin/CDR0000658698.jpg" alt="Anatomy of the liver; drawing shows the right and left lobes of the liver. Also shown are the bile ducts, gallbladder, stomach, spleen, pancreas, small intestine, and colon." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Anatomy of the liver. The liver is in the upper abdomen near the stomach, intestines, gallbladder, and pancreas. The liver has a right lobe and a left lobe. Each lobe is divided into two sections (not shown). </p></div></div><p id="CDR0000569404__74">See the following <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044271/" class="def">PDQ</a> summaries for more information about <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044242/" class="def">liver (hepatocellular) cancer</a>:</p><ul id="CDR0000569404__73"><li class="half_rhythm"><div><a href="/books/n/pdqcis/CDR0000433423/">Liver (Hepatocellular) Cancer Prevention</a></div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/CDR0000256491/">Adult Primary Liver Cancer Treatment</a></div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/CDR0000258119/">Childhood Liver Cancer Treatment</a></div></li></ul></div><div id="CDR0000569404__13"><h3>Liver cancer is less common in the United States than in other parts of the world.</h3><p id="CDR0000569404__15">Liver cancer is uncommon in the United States, but in 2018, was the fourth leading cause of cancer death in the world. In the United States, men of all <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000784950/" class="def">ethnic groups</a> have a greater risk of developing liver cancer than women.</p></div><div id="CDR0000569404__16"><h3>Having hepatitis or cirrhosis can increase the risk of developing liver cancer.</h3><p id="CDR0000569404__18">Anything that increases the chance of getting a disease is called a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045873/" class="def">risk factor</a>. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. People who think they may be at risk should discuss this with their doctor. Risk factors for liver cancer include:</p><ul id="CDR0000569404__19"><li class="half_rhythm"><div>Having <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046146/" class="def">hepatitis B</a> or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044139/" class="def">hepatitis C</a>; having both hepatitis B and hepatitis C increases the risk even more.</div></li><li class="half_rhythm"><div>Having <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045478/" class="def">cirrhosis</a>, which can be caused by: <dl id="CDR0000569404__71" class="temp-labeled-list"><dt>-</dt><dd><p class="no_top_margin"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046371/" class="def">hepatitis</a> (especially hepatitis C); or</p></dd><dt>-</dt><dd><p class="no_top_margin">drinking large amounts of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000463134/" class="def">alcohol</a> for many years or being an alcoholic.</p></dd></dl></div></li><li class="half_rhythm"><div>Eating foods tainted with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046206/" class="def">aflatoxin</a> (poison from a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044571/" class="def">fungus</a> that can grow on foods, such as grains and nuts, that have not been stored properly).</div></li></ul></div></div><div id="CDR0000569404__20"><h2 id="_CDR0000569404__20_">Liver (Hepatocellular) Cancer Screening</h2><div id="CDR0000569404__20.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000569404__21">Tests are used to screen for different types of cancer when a person does not have symptoms.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000569404__26">There is no standard or routine screening test for liver cancer.</a></div><ul><li class="half_rhythm"><div><a href="#CDR0000569404__31">Ultrasound</a></div></li><li class="half_rhythm"><div><a href="#CDR0000569404__63">CT scan</a></div></li><li class="half_rhythm"><div><a href="#CDR0000569404__28">Tumor markers</a></div></li></ul></li><li class="half_rhythm"><div><a href="#CDR0000569404__78">Screening tests for liver cancer are being studied in clinical trials.</a></div></li></ul></div><div id="CDR0000569404__21"><h3>Tests are used to screen for different types of cancer when a person does not have symptoms.</h3><p id="CDR0000569404__24"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044724/" class="def">Scientists</a> study <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046171/" class="def">screening</a> tests to find those with the fewest harms and most benefits. <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">Cancer</a> screening trials also are meant to show whether early detection (finding cancer before it causes <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>) helps a person live longer or decreases a person's chance of dying from the disease. For some types of cancer, the chance of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454708/" class="def">recovery</a> is better if the disease is found and treated at an early <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045885/" class="def">stage</a>.</p></div><div id="CDR0000569404__26"><h3>There is no standard or routine screening test for liver cancer.</h3><p id="CDR0000569404__72">Although there are no standard or routine screening tests for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044242/" class="def">liver cancer</a>, the following tests are being used or studied to screen for it:</p><div id="CDR0000569404__31"><h4>Ultrasound</h4><p id="CDR0000569404__33"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046157/" class="def">Ultrasound</a> is a procedure in which high-energy sound waves (ultrasound) are bounced off the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046312/" class="def">liver</a> and make echoes. The echoes form a picture of the liver called a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046587/" class="def">sonogram</a>. The picture can be printed to be looked at later. </p></div><div id="CDR0000569404__63"><h4>CT scan</h4><p id="CDR0000569404__65"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046033/" class="def">CT scan</a> is a procedure that makes a series of detailed pictures of the liver, taken from different angles. The pictures are made by a computer linked to an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045944/" class="def">x-ray</a> machine. A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000409764/" class="def">dye</a> may be <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044678/" class="def">injected</a> into a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476471/" class="def">vein</a> or swallowed to help the liver show up more clearly. This procedure is also called CAT scan or computed tomography.</p></div><div id="CDR0000569404__28"><h4>Tumor markers</h4><p id="CDR0000569404__30"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046636/" class="def">Tumor markers</a>, also called biomarkers, are substances made by the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> that may be found in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a>, other body <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044669/" class="def">fluids</a>, or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissues</a>. A high level of a specific tumor marker may mean that a certain type of cancer is present in the body.</p><p id="CDR0000569404__66"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046208/" class="def">Alpha-fetoprotein</a> (AFP) is the most widely used tumor marker for detecting liver cancer. However, other cancers and certain <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">conditions</a>, including <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000666677/" class="def">pregnancy</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046371/" class="def">hepatitis</a>, and other types of cancer, may also increase AFP levels.</p><p id="CDR0000569404__67"> Specific tumor markers that may lead to early detection of liver cancer are being studied.</p><p id="CDR0000569404__68"> Information about ongoing clinical trials is available from the <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">NCI website</a>.</p></div></div><div id="CDR0000569404__78"><h3>Screening tests for liver cancer are being studied in clinical trials.</h3><p id="CDR0000569404__20_95">Information about clinical trials supported by NCI can be found on NCI&#x02019;s <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">clinical trials search</a> webpage. Clinical trials supported by other organizations can be found on the <a href="https://clinicaltrials.gov/" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">ClinicalTrials.gov</a> website.</p></div></div><div id="CDR0000569404__43"><h2 id="_CDR0000569404__43_">Risks of Liver (Hepatocellular) Cancer Screening</h2><div id="CDR0000569404__43.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000569404__44">Screening tests have risks.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000569404__47">The risks of liver cancer screening include the following:</a></div><ul><li class="half_rhythm"><div><a href="#CDR0000569404__49">False-negative test results can occur.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000569404__52">False-positive test results can occur.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000569404__55">Side effects may be caused by procedures to diagnose liver cancer.</a></div></li></ul></li></ul></div><div id="CDR0000569404__44"><h3>Screening tests have risks.</h3><p id="CDR0000569404__46">Decisions about <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046171/" class="def">screening</a> tests can be difficult. Not all screening tests are helpful and most have risks. Before having any screening test, you may want to discuss the test with your doctor. It is important to know the risks of the test and whether it has been proven to reduce the risk of dying from <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>.</p></div><div id="CDR0000569404__47"><h3>The risks of liver cancer screening include the following:</h3><div id="CDR0000569404__49"><h4>False-negative test results can occur.</h4><p id="CDR0000569404__51">Screening test results may appear to be normal even though <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044242/" class="def">liver cancer</a> is present. A person who receives a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000340928/" class="def">false-negative test result</a> (one that shows there is no cancer when there really is) may delay seeking medical care even if there are <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>.</p></div><div id="CDR0000569404__52"><h4>False-positive test results can occur.</h4><p id="CDR0000569404__54">Screening test results may appear to be <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044636/" class="def">abnormal</a> even though no cancer is present. A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000340929/" class="def">false-positive test result</a> (one that shows there is cancer when there really isn't) can cause <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000430405/" class="def">anxiety</a> and is usually followed by <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045959/" class="def">diagnostic tests</a> and procedures, such as a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046312/" class="def">liver</a>
<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045164/" class="def">biopsy</a>, which also have risks.</p></div><div id="CDR0000569404__55"><h4>Side effects may be caused by procedures to diagnose liver cancer.</h4><p id="CDR0000569404__57">Abnormal screening results may lead to a liver biopsy to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnose</a> liver cancer. Liver biopsy may cause the following rare, but serious, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a>:</p><ul id="CDR0000569404__58"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373015/" class="def">Hemorrhage</a>.</div></li><li class="half_rhythm"><div> Trouble breathing.</div></li><li class="half_rhythm"><div>Leakage of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046508/" class="def">bile</a>, which can cause an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045364/" class="def">infection</a> of the lining of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045070/" class="def">abdomen</a>.</div></li><li class="half_rhythm"><div>A small puncture (hole) in an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000257523/" class="def">organ</a> in the abdomen.</div></li><li class="half_rhythm"><div>Spread of cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> along the needle path when the biopsy needle is inserted and withdrawn (taken out).</div></li></ul><p id="CDR0000569404__70">Your doctor can advise you about your risk for liver cancer and your need for screening tests.</p></div></div></div><div id="CDR0000569404__AboutThis_1"><h2 id="_CDR0000569404__AboutThis_1_">About This PDQ Summary</h2><div id="CDR0000569404__AboutThis_2"><h3>About PDQ</h3><p id="CDR0000569404__AboutThis_3">Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in <a href="https://www.cancer.gov/espanol/publicaciones/pdq" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Spanish</a>.</p><p id="CDR0000569404__AboutThis_4">PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government&#x02019;s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.</p></div><div id="CDR0000569404__AboutThis_5"><h3>Purpose of This Summary</h3><p id="CDR0000569404__AboutThis_6">This PDQ cancer information summary has current information about liver (hepatocellular) cancer screening. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p></div><div id="CDR0000569404__AboutThis_7"><h3>Reviewers and Updates</h3><p id="CDR0000569404__AboutThis_8">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change.
</p><p id="CDR0000569404__AboutThis_9">The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the <a href="https://www.cancer.gov/publications/pdq/editorial-boards/screening-prevention" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">PDQ Screening and Prevention Editorial Board</a>.
</p></div><div id="CDR0000569404__AboutThis_10"><h3>Clinical Trial Information</h3><p id="CDR0000569404__AboutThis_11">A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
</p><p id="CDR0000569404__AboutThis_12">Clinical trials can be found online at <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">NCI's website</a>. For more information, call the <a href="https://www.cancer.gov/contact/contact-center" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Cancer Information Service</a> (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237).
</p></div><div id="CDR0000569404__AboutThis_13"><h3>Permission to Use This Summary</h3><p id="CDR0000569404__AboutThis_14">PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as &#x0201c;NCI&#x02019;s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].&#x0201d;
</p><p id="CDR0000569404__AboutThis_15">The best way to cite this PDQ summary is:</p><p id="CDR0000569404__AboutThis_21">PDQ&#x000ae; Screening and Prevention Editorial Board. PDQ Liver (Hepatocellular) Cancer Screening. Bethesda, MD: National Cancer Institute. Updated &#x0003c;MM/DD/YYYY&#x0003e;. Available at: <a href="https://www.cancer.gov/types/liver/patient/liver-screening-pdq" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">https://www.cancer.gov/types/liver/patient/liver-screening-pdq</a>. Accessed &#x0003c;MM/DD/YYYY&#x0003e;. [PMID: 26389386]</p><p id="CDR0000569404__AboutThis_16">Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in <a href="https://visualsonline.cancer.gov/" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Visuals Online</a>. Visuals Online is a collection of more than 3,000 scientific images.
</p></div><div id="CDR0000569404__AboutThis_17"><h3>Disclaimer</h3><p id="CDR0000569404__AboutThis_18">The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the <a href="https://www.cancer.gov/about-cancer/managing-care" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Managing Cancer Care</a> page.</p></div><div id="CDR0000569404__AboutThis_19"><h3>Contact Us</h3><p id="CDR0000569404__AboutThis_20">More information about contacting us or receiving help with the Cancer.gov website can be found on our <a href="https://www.cancer.gov/contact" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Contact Us for Help</a> page. Questions can also be submitted to Cancer.gov through the website&#x02019;s <a href="https://www.cancer.gov/contact/email-us" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">E-mail Us</a>.</p></div></div></div></div>
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Liver (Hepatocellular) Cancer Screening (PDQ®): Patient Version. 2020 Aug 5. In: PDQ Cancer Information Summaries [Internet]. 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2021</li><li><span class="bk_col_itm">NBK65948.4</span> August 5, 2020 (Displayed Version)</li><li><span class="bk_col_itm"><a href="/books/NBK65948.3/">NBK65948.3</a></span> March 22, 2019</li><li><span class="bk_col_itm"><a href="/books/NBK65948.2/">NBK65948.2</a></span> May 15, 2018</li><li><span class="bk_col_itm"><a href="/books/NBK65948.1/">NBK65948.1</a></span> July 31, 2015</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this Page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#CDR0000569404__1" ref="log$=inpage&amp;link_id=inpage">What is screening?</a></li><li><a href="#CDR0000569404__8" ref="log$=inpage&amp;link_id=inpage">General Information About Liver (Hepatocellular) Cancer</a></li><li><a href="#CDR0000569404__20" ref="log$=inpage&amp;link_id=inpage">Liver (Hepatocellular) Cancer Screening</a></li><li><a href="#CDR0000569404__43" ref="log$=inpage&amp;link_id=inpage">Risks of Liver (Hepatocellular) Cancer Screening</a></li><li><a href="#CDR0000569404__AboutThis_1" ref="log$=inpage&amp;link_id=inpage">About This PDQ Summary</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related publications</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK65785/">Health Professional Version</a></li></ul></div></div><div 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