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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="PDQ Cancer Information Summaries [Internet]" /><meta name="citation_title" content="Neuroblastoma Treatment (PDQ®)" /><meta name="citation_publisher" content="National Cancer Institute (US)" /><meta name="citation_date" content="2018/03/16" /><meta name="citation_author" content="PDQ Pediatric Treatment Editorial Board" /><meta name="citation_pmid" content="26389278" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK65838/" /><meta name="citation_keywords" content="neuroblastoma" /><meta name="citation_keywords" content="neuroblastoma" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Neuroblastoma Treatment (PDQ®)" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Cancer Institute (US)" /><meta name="DC.Contributor" content="PDQ Pediatric Treatment Editorial Board" /><meta name="DC.Date" content="2018/03/16" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK65838/" /><meta name="description" content="Neuroblastoma treatment may include surgery, observation, chemotherapy, radiation therapy, radioactive iodine, and high-dose chemotherapy with stem cell transplant and targeted therapy. Treatment also depends on risk category. Learn more in this expert-reviewed summary." /><meta name="og:title" content="Neuroblastoma Treatment (PDQ®)" /><meta name="og:type" content="book" /><meta name="og:description" content="Neuroblastoma treatment may include surgery, observation, chemotherapy, radiation therapy, radioactive iodine, and high-dose chemotherapy with stem cell transplant and targeted therapy. Treatment also depends on risk category. Learn more in this expert-reviewed summary." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK65838/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/pdqcis/CDR0000258023/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK65838/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/pdqcis/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" alt="Cover of PDQ Cancer Information Summaries" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>PDQ Cancer Information Summaries [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK65838_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK65838_dtls__"><div>Bethesda (MD): <a href="http://www.cancer.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Cancer Institute (US)</a>; 2002-.</div></div><div class="half_rhythm"></div><div class="bk_noprnt"><form method="get" action="/books/n/pdqcis/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK65838_"><span class="title" itemprop="name">Neuroblastoma Treatment (PDQ®)</span></h1><div class="subtitle whole_rhythm">Patient Version</div><p class="contrib-group"><span itemprop="author">PDQ Pediatric Treatment Editorial Board</span>.</p><p class="small">Published online: March 16, 2018.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><p id="CDR0000258023__283">This PDQ cancer information summary has current information about the treatment of neuroblastoma. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p><p id="CDR0000258023__284">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change. The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Pediatric Treatment Editorial Board.</p></div><div id="CDR0000258023__1"><h2 id="_CDR0000258023__1_">General Information About Neuroblastoma</h2><div class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000258023__2">Neuroblastoma is a disease in which malignant (cancer) cells form in neuroblasts (immature nerve tissue) in the adrenal gland, neck, chest, or spinal cord.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__230">Neuroblastoma is sometimes caused by a gene mutation (change) passed from the parent to the child.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__7">Signs and symptoms of neuroblastoma include bone pain and a lump in the abdomen, neck, or chest. </a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__13">Tests that examine many different body tissues and fluids are used to detect (find)
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and diagnose neuroblastoma.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__265">A biopsy is done to diagnose neuroblastoma.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__18">Certain factors affect prognosis (chance
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of recovery) and treatment options.</a></div></li></ul></div><div id="CDR0000258023__2"><h3>Neuroblastoma is a disease in which malignant (cancer) cells form in neuroblasts (immature nerve tissue) in the adrenal gland, neck, chest, or spinal cord.</h3><p id="CDR0000258023__4"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">Neuroblastoma</a> often begins in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373935/" class="def">nerve</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a> of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046678/" class="def">adrenal glands</a>. There are two adrenal glands, one on top of each <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046325/" class="def">kidney</a> in the back of the upper <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045070/" class="def">abdomen</a>. The adrenal glands make important <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045713/" class="def">hormones</a> that help control heart rate, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000462668/" class="def">blood pressure</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000658770/" class="def">blood sugar</a>, and the way the body reacts to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000450122/" class="def">stress</a>. Neuroblastoma may also begin in nerve tissue in the neck, chest, abdomen or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046246/" class="def">pelvis</a>. <div id="CDR0000258023__282" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Neuroblastoma%20may%20be%20found%20in%20the%20adrenal%20glands%20and%20paraspinal%20nerve%20tissue%20from%20the%20neck%20to%20the%20pelvis&p=BOOKS&id=487861_CDR0000756627.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK65838.13/bin/CDR0000756627.jpg" alt="Drawing shows parts of the body where neuroblastoma may be found, including the paraspinal nerve tissue and the adrenal glands. Also shown are the spine and right and left kidney." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Neuroblastoma may be found in the adrenal glands and paraspinal nerve tissue from the neck to the pelvis.</p></div></div></p><p id="CDR0000258023__6">Neuroblastoma most often begins in infancy and may be <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnosed</a> in the first month of life. It is found when the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> begins to grow and cause <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000750109/" class="def">signs</a> or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>. Sometimes it forms before birth and is found during a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046400/" class="def">fetal</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046157/" class="def">ultrasound</a>.</p><p id="CDR0000258023__5">By the time neuroblastoma is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnosed</a>, the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> has usually <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046283/" class="def">metastasized</a> (spread). Neuroblastoma spreads most often to the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045762/" class="def">lymph nodes</a>, bones, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045622/" class="def">bone marrow</a>, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046312/" class="def">liver</a>. In infants, it also spreads to the skin.</p></div><div id="CDR0000258023__230"><h3>Neuroblastoma is sometimes caused by a gene mutation (change) passed from the parent to the child.</h3><p id="CDR0000258023__232"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045693/" class="def">Gene</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046063/" class="def">mutations</a> that increase the risk of neuroblastoma are sometimes <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045098/" class="def">inherited</a> (passed from the parent to the child). In children with a gene mutation, neuroblastoma usually occurs at a younger age and more than one tumor may form in the adrenal glands.</p></div><div id="CDR0000258023__7"><h3>Signs and symptoms of neuroblastoma include bone pain and a lump in the abdomen, neck, or chest. </h3><p id="CDR0000258023__9">The most common signs and symptoms of neuroblastoma are caused by the tumor pressing on nearby tissues as it grows or by cancer spreading to the bone. These and other signs and symptoms may be caused by neuroblastoma or by other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">conditions</a>.</p><p id="CDR0000258023__264">Check with your child’s doctor if your child has any of the following:</p><ul id="CDR0000258023__10"><li class="half_rhythm"><div>Lump in the abdomen, neck, or chest.</div></li><li class="half_rhythm"><div>Bulging eyes.</div></li><li class="half_rhythm"><div>Dark circles around the eyes ("black eyes").</div></li><li class="half_rhythm"><div>Bone pain.</div></li><li class="half_rhythm"><div>Swollen <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046604/" class="def">stomach</a> and trouble breathing (in infants).</div></li><li class="half_rhythm"><div>Painless, bluish lumps under the skin (in infants).</div></li><li class="half_rhythm"><div>Weakness or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046242/" class="def">paralysis</a> (loss of ability to move a body part).</div></li></ul><p id="CDR0000258023__11">Less common signs and symptoms of neuroblastoma include the following:</p><ul id="CDR0000258023__12"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000450108/" class="def">Fever</a>.</div></li><li class="half_rhythm"><div>Shortness of breath.</div></li><li class="half_rhythm"><div>Feeling tired.</div></li><li class="half_rhythm"><div>Easy bruising or bleeding.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046236/" class="def">Petechiae</a> (flat, pinpoint spots under the skin caused by bleeding).</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000458091/" class="def">High blood pressure</a>. </div></li><li class="half_rhythm"><div>Severe watery <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000306496/" class="def">diarrhea</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044240/" class="def">Horner syndrome</a> (droopy eyelid, smaller <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000546600/" class="def">pupil</a>, and less sweating on one side of the face).</div></li><li class="half_rhythm"><div>Jerky muscle movements.</div></li><li class="half_rhythm"><div>Uncontrolled eye movements.</div></li></ul></div><div id="CDR0000258023__13"><h3><div class="milestone-start" id="CDR0000258023__14"></div>Tests that examine many different body tissues and fluids are used to detect (find)
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and diagnose neuroblastoma.<div class="milestone-end"></div></h3><p id="CDR0000258023__15">The following tests and procedures may be used:</p><ul id="CDR0000258023__16"><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270871/" class="def">Physical exam</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000689078/" class="def">history</a></b>: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000322871/" class="def">Neurological exam</a></b>: A series of questions and tests to check the brain, spinal cord, and nerve function. The exam checks a person’s mental status, coordination, and ability to walk normally, and how well the muscles, senses, and reflexes work. This may also be called a neuro exam or a neurologic exam.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046642/" class="def">Urine</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000537553/" class="def">catecholamine</a> studies</b>: A procedure in which a urine sample is checked to measure the amount of certain substances, vanillylmandelic acid (VMA) and homovanillic acid (HVA), that are made when catecholamines break down and are released into the urine. A higher than normal amount of VMA or HVA can be a sign of neuroblastoma.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000304685/" class="def">Blood chemistry studies</a></b>: A procedure in which a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a> sample is checked to measure the amounts of certain substances released into the blood by <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000257523/" class="def">organs</a> and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease. </div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045944/" class="def">X-ray</a></b>: An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046033/" class="def">CT scan</a> (CAT scan)</b>: A procedure that makes a series of detailed pictures of areas inside the body, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000409764/" class="def">dye</a> may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography. <div id="CDR0000258023__286" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Computed%20tomography%20(CT)%20scan%20of%20the%20abdomen&p=BOOKS&id=487861_CDR0000775531.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK65838.13/bin/CDR0000775531.jpg" alt="Computed tomography (CT) scan of the abdomen; drawing shows a child lying on a table that slides through the CT scanner, which takes x-ray pictures of the inside of the abdomen." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Computed tomography (CT) scan of the abdomen. The child lies on a table that slides through the CT scanner, which takes x-ray pictures of the inside of the abdomen.</p></div></div></div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045788/" class="def">MRI</a> (magnetic resonance imaging) with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000597153/" class="def">gadolinium</a></b>: A procedure that uses a magnet, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651209/" class="def">radio waves</a>, and a computer to make a series of detailed pictures of areas inside the body. A substance called gadolinium is injected into a vein. The gadolinium collects around the cancer cells so they show up brighter in the picture. This procedure is also called nuclear magnetic resonance imaging (NMRI).<div id="CDR0000258023__288" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Magnetic%20resonance%20imaging%20(MRI)%20of%20the%20abdomen&p=BOOKS&id=487861_CDR0000775532.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK65838.13/bin/CDR0000775532.jpg" alt="Magnetic resonance imaging (MRI) of the abdomen; drawing shows a child lying on a table that slides into the MRI scanner, which takes pictures of the inside of the body. The pad on the child’s abdomen helps make the pictures clearer." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Magnetic resonance imaging (MRI) of the abdomen. The child lies on a table that slides into the MRI scanner, which takes pictures of the inside of the body. The pad on the child’s abdomen helps make the pictures clearer.</p></div></div></div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000736798/" class="def">MIBG (metaiodobenzylguanidine) scan</a></b>: A procedure used to find <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044904/" class="def">neuroendocrine tumors</a>, such as neuroblastoma. A very small amount of a substance called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046550/" class="def">radioactive</a> MIBG is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044678/" class="def">injected</a> into a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476471/" class="def">vein</a> and travels through the bloodstream. Neuroendocrine tumor <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> take up the radioactive MIBG and are detected by a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000386220/" class="def">scanner</a>. Scans may be taken over 1-3 days. An <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044548/" class="def">iodine</a> solution may be given before or during the test to keep the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044751/" class="def">thyroid gland</a> from absorbing too much of the MIBG. This test is also used to find out how well the tumor is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">responding</a> to treatment. MIBG is used in high <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044664/" class="def">doses</a> to treat neuroblastoma.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046505/" class="def">Bone marrow aspiration</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046506/" class="def">biopsy</a></b>: The removal of bone marrow, blood, and a small piece of bone by inserting a hollow needle into the hipbone or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000549425/" class="def">breastbone</a>. A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046244/" class="def">pathologist</a> views the bone marrow, blood, and bone under a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000638184/" class="def">microscope</a> to look for signs of cancer.<div id="CDR0000258023__285" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Bone%20marrow%20aspiration%20and%20biopsy&p=BOOKS&id=487861_CDR0000775458.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK65838.13/bin/CDR0000775458.jpg" alt="Bone marrow aspiration and biopsy; drawing shows a child lying face down on a table and a bone marrow needle being inserted into the right hip bone. An inset shows the bone marrow needle being inserted through the skin into the bone marrow of the hip bone." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Bone marrow aspiration and biopsy. After a small area of skin is numbed, a bone marrow needle is inserted into the child’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.</p></div></div></div></li><li class="half_rhythm"><div><b>Ultrasound exam</b>: A procedure in which high-energy sound waves (ultrasound) are bounced off internal tissues or organs and make echoes. The echoes form a picture of body tissues called a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046587/" class="def">sonogram</a>. The picture can be printed to be looked at later. An ultrasound exam is not done if a CT/MRI has been done.<div id="CDR0000258023__287" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Abdominal%20ultrasound&p=BOOKS&id=487861_CDR0000775457.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK65838.13/bin/CDR0000775457.jpg" alt="Abdominal ultrasound; drawing shows a child lying on an exam table during an abdominal ultrasound procedure. A technician is shown pressing a transducer (a device that makes sound waves that bounce off tissues inside the body) against the skin of the abdomen. A computer screen shows a sonogram (picture)." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Abdominal ultrasound. An ultrasound transducer connected to a computer is pressed against the skin of the abdomen. The transducer bounces sound waves off internal organs and tissues to make echoes that form a sonogram (computer picture).</p></div></div></div></li></ul></div><div id="CDR0000258023__265"><h3>A biopsy is done to diagnose neuroblastoma.</h3><p id="CDR0000258023__267">
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Cells and tissues are removed during a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045164/" class="def">biopsy</a> so they can be viewed under a microscope by a pathologist to check for signs of cancer. The way the biopsy is done depends on where the tumor is in the body. Sometimes the whole tumor is removed at the same time the biopsy is done.</p><p id="CDR0000258023__268">The following tests may be done on the tissue that is removed:
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</p><ul id="CDR0000258023__269"><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270737/" class="def">Cytogenetic analysis</a></b>: A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046590/" class="def">laboratory test</a> in which cells in a sample of tissue are viewed under a microscope to look for certain changes in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046470/" class="def">chromosomes</a>. </div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044052/" class="def">Light microscopy</a></b>: A laboratory test in which cells in a sample of tissue are viewed under regular and high-powered microscopes to look for certain changes in the cells.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000653117/" class="def">Immunohistochemistry</a></b>: A test that uses <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044918/" class="def">antibodies</a> to check for certain <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046086/" class="def">antigens</a> in a sample of tissue. The antibody is usually linked to a radioactive substance or a dye that causes the tissue to light up under a microscope. This type of test may be used to tell the difference between different types of cancer.</div></li><li class="half_rhythm"><div><b>MYCN amplification study </b>: A laboratory study in which tumor or bone marrow cells are checked for the level of <i>MYCN</i>. <i>MYCN</i> is important for cell growth. A higher level of <i>MYCN</i> (more than 10 copies of the gene) is called <i>MYCN</i> amplification. Neuroblastoma with <i>MYCN</i> amplification is more likely to spread in the body and less likely to respond to treatment.</div></li></ul><p id="CDR0000258023__281">Children up to 6 months old may not need a biopsy or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a> to remove the tumor because the tumor may disappear without treatment.</p></div><div id="CDR0000258023__18"><h3>Certain factors affect prognosis (chance
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of recovery) and treatment options.</h3><p id="CDR0000258023__20">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045849/" class="def">prognosis</a> (chance of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454708/" class="def">recovery</a>) and treatment options depend on the following:</p><ul id="CDR0000258023__159"><li class="half_rhythm"><div>Age of the child at the time of diagnosis.</div></li><li class="half_rhythm"><div>The child's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000711109/" class="def">risk group</a>.</div></li><li class="half_rhythm"><div>Whether there are certain changes in the genes.</div></li><li class="half_rhythm"><div>Where in the body the tumor started.</div></li><li class="half_rhythm"><div>Tumor <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044171/" class="def">histology</a> (the shape, function, and structure of the tumor cells).</div></li><li class="half_rhythm"><div>Whether there is cancer in the lymph nodes on the same side of the body as the primary cancer or whether there is cancer in the lymph nodes on the opposite side of the body.</div></li><li class="half_rhythm"><div>How the tumor responds to treatment.</div></li><li class="half_rhythm"><div>How much time passed between diagnosis and when the cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurred</a> (for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045862/" class="def">recurrent cancer</a>).</div></li></ul><p id="CDR0000258023__192">Prognosis and treatment options for neuroblastoma are also affected by tumor biology, which includes: </p><ul id="CDR0000258023__163"><li class="half_rhythm"><div>The patterns of the tumor cells.</div></li><li class="half_rhythm"><div>How different the tumor cells are from normal cells.</div></li><li class="half_rhythm"><div>How fast the tumor cells are growing.</div></li><li class="half_rhythm"><div>Whether the tumor shows <i>MYCN</i> amplification.</div></li><li class="half_rhythm"><div>Whether the tumor has changes in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000721252/" class="def">ALK</a> gene.</div></li></ul><p id="CDR0000258023__193"> The tumor biology is said to be favorable or unfavorable, depending on these factors. A favorable tumor biology means there is a better chance of recovery.</p><p id="CDR0000258023__237">In some children up to 6 months old, neuroblastoma may disappear without treatment. This is called spontaneous regression. The child is closely watched for signs or symptoms of neuroblastoma. If signs or symptoms occur, treatment may be needed.</p></div></div><div id="CDR0000258023__21"><h2 id="_CDR0000258023__21_">Stages of Neuroblastoma</h2><div class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000258023__22">After neuroblastoma has been diagnosed, tests are done to find out
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if cancer has spread from where it started to other parts of the body.
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</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__219">There are three ways that cancer spreads in the body.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__250">Cancer may spread from where it began to other parts of the body.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__164">The following stages are used for neuroblastoma:</a></div><ul><li class="half_rhythm"><div><a href="#CDR0000258023__203">Stage 1</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__184">Stage 2</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__194">Stage 3</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__197">Stage 4</a></div></li></ul></li><li class="half_rhythm"><div><a href="#CDR0000258023__28">Treatment of neuroblastoma is based on risk groups.</a></div></li></ul></div><div id="CDR0000258023__22"><h3>After neuroblastoma has been diagnosed, tests are done to find out
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if cancer has spread from where it started to other parts of the body.
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</h3><p id="CDR0000258023__122">The process used to find out the extent or spread of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> is called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046597/" class="def">staging</a>. The information gathered from the staging process helps determine the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045885/" class="def">stage</a> of the disease. For <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a>, the stage of disease affects whether the cancer is low risk, intermediate risk, or high risk. It also affects the treatment plan. The results of some tests and procedures used to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnose</a> neuroblastoma may be used for staging. See the <a href="#CDR0000258023__14">General Information</a> section for a description of these tests and procedures.</p><p id="CDR0000258023__270">The following tests and procedures also may be used to determine the stage:</p><ul id="CDR0000258023__25"><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045762/" class="def">Lymph node</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045164/" class="def">biopsy</a></b>: The removal of all or part of a lymph node. A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046244/" class="def">pathologist</a> views the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a> under a microscope to look for cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a>. One of the following types of biopsies may be done:
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<dl id="CDR0000258023__26" class="temp-labeled-list"><dt>-</dt><dd><p class="no_top_margin"><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046411/" class="def">Excisional biopsy</a></b>: The removal of an entire lymph node.</p></dd><dt>-</dt><dd><p class="no_top_margin"><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046698/" class="def">Incisional biopsy</a></b>: The removal of part of a lymph node.</p></dd><dt>-</dt><dd><p class="no_top_margin"><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045657/" class="def">Core biopsy</a></b>: The removal of tissue from a lymph node using a wide needle. </p></dd><dt>-</dt><dd><p class="no_top_margin"><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045691/" class="def">Fine-needle aspiration (FNA) biopsy</a></b>: The removal of tissue or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044669/" class="def">fluid</a> from a
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lymph node using a thin needle.</p></dd></dl>
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</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045944/" class="def">X-ray</a> of the bone</b>: An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046140/" class="def">PET scan</a> (positron emission tomography scan)</b>: A procedure to find <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045772/" class="def">malignant</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> cells in the body. A small amount of radioactive glucose (sugar) is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044678/" class="def">injected</a> into a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476471/" class="def">vein</a>. The PET <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000386220/" class="def">scanner</a> rotates around the body and makes a picture of where <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044033/" class="def">glucose</a> is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells do.</div></li></ul></div><div id="CDR0000258023__219"><h3>There are three ways that cancer spreads in the body.</h3><p id="CDR0000258023__219_69">Cancer can spread through <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a>, the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045764/" class="def">lymph system</a>, and the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a>:</p><ul id="CDR0000258023__219_70"><li class="half_rhythm"><div>Tissue. The cancer spreads from where it began by growing into nearby areas.
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</div></li><li class="half_rhythm"><div>Lymph system. The cancer spreads from where it began by getting into the lymph system. The cancer travels through the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000269462/" class="def">lymph vessels</a> to other parts of the body.
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</div></li><li class="half_rhythm"><div>Blood. The cancer spreads from where it began by getting into the blood. The cancer travels through the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045020/" class="def">blood vessels</a> to other parts of the body.
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</div></li></ul></div><div id="CDR0000258023__250"><h3>Cancer may spread from where it began to other parts of the body.</h3><p id="CDR0000258023__250_66">When cancer spreads to another part of the body, it is called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046710/" class="def">metastasis</a>. Cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> break away from where they began (the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045847/" class="def">primary tumor</a>) and travel through the lymph system or blood.</p><ul id="CDR0000258023__250_67"><li class="half_rhythm"><div>Lymph system. The cancer gets into the lymph system, travels through the lymph vessels, and forms a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044058/" class="def">metastatic</a> tumor) in another part of the body.</div></li><li class="half_rhythm"><div>Blood. The cancer gets into the blood, travels through the blood vessels, and forms a tumor (metastatic tumor) in another part of the body.</div></li></ul><p id="CDR0000258023__252">The metastatic tumor is the same type of cancer as the primary tumor. For example, if neuroblastoma spreads to the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046312/" class="def">liver</a>, the cancer cells in the liver are actually neuroblastoma cells. The disease is metastatic neuroblastoma, not liver cancer.</p><div id="CDR0000258023__306" class="box"><h3><span class="title">metastasis: how cancer spreads</span></h3><div class="caption"><p>Many cancer deaths are caused when cancer moves from the original tumor and spreads to other tissues and organs. This is called metastatic cancer. This animation shows how cancer cells travel from the place in the body where they first formed to other parts of the body.</p></div><p><a href="https://www.youtube.com/watch?v=fQwar_-QdiQ" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">YouTube</a></p></div></div><div id="CDR0000258023__164"><h3>The following stages are used for neuroblastoma:</h3><div id="CDR0000258023__203"><h4>Stage 1</h4><p id="CDR0000258023__166">In <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000428440/" class="def">stage 1</a>, the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> is in only one area and all of the tumor that can be seen is completely removed during <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a>.</p></div><div id="CDR0000258023__184"><h4>Stage 2</h4><p id="CDR0000258023__169"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000396789/" class="def">Stage 2</a> is divided into stages 2A and 2B.</p><ul id="CDR0000258023__170"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000396789/" class="def">Stage 2A</a>: The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> is in only one area and all of the tumor that can be seen cannot be completely removed during <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000396789/" class="def">Stage 2B</a>: The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> is in only one area and all of the tumor that can be seen <i>may</i> be completely removed during <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a>. <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">Cancer</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> are found in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045762/" class="def">lymph nodes</a> near the tumor.</div></li></ul></div><div id="CDR0000258023__194"><h4>Stage 3</h4><p id="CDR0000258023__196">In <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000396790/" class="def">stage 3</a>, one of the following is true:</p><ul id="CDR0000258023__177"><li class="half_rhythm"><div>the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> cannot be completely removed during <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a> and has spread from one side of the body to the other side and may also have spread to nearby <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045762/" class="def">lymph nodes</a>; or</div></li><li class="half_rhythm"><div>the tumor is in only one area, on one side of the body, but has spread to lymph nodes on the other side of the body; or</div></li><li class="half_rhythm"><div>the tumor is in the middle of the body and has spread to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissues</a> or lymph nodes on both sides of the body, and the tumor cannot be removed by surgery.</div></li></ul></div><div id="CDR0000258023__197"><h4>Stage 4</h4><p id="CDR0000258023__199"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000396792/" class="def">Stage 4</a> is divided into stages 4 and 4S.</p><ul id="CDR0000258023__178"><li class="half_rhythm"><div>In <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000396792/" class="def">stage 4</a>, the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> has spread to distant <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045762/" class="def">lymph nodes</a> or other parts of the body.</div></li><li class="half_rhythm"><div>In <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000396792/" class="def">stage 4S</a>: <dl id="CDR0000258023__179" class="temp-labeled-list"><dt>-</dt><dd><p class="no_top_margin">the child is younger than 12 months; and</p></dd><dt>-</dt><dd><p class="no_top_margin">the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> has spread to the skin, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046312/" class="def">liver</a>, and/or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045622/" class="def">bone marrow</a>; and</p></dd><dt>-</dt><dd><p class="no_top_margin">the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> is in only one area and all of the tumor that can be seen <i>may</i> be completely removed during <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a>; and/or</p></dd><dt>-</dt><dd><p class="no_top_margin">cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> may be found in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045762/" class="def">lymph nodes</a> near the tumor. </p></dd></dl></div></li></ul></div></div><div id="CDR0000258023__28"><h3>Treatment of neuroblastoma is based on risk groups.</h3><p id="CDR0000258023__180"> For many types of cancer, stages are used to plan treatment. For neuroblastoma, treatment depends on <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000711109/" class="def">risk groups</a>. The stage of neuroblastoma is one factor used to determine risk group. Other factors are the age of the child, tumor <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044171/" class="def">histology</a>, and <a href="#CDR0000258023__192">tumor biology</a>.</p><p id="CDR0000258023__181">There are three risk groups: low risk, intermediate risk, and high risk.</p><ul id="CDR0000258023__182"><li class="half_rhythm"><div>Low-risk and intermediate-risk neuroblastoma have a good chance of being <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000318813/" class="def">cured</a>.</div></li><li class="half_rhythm"><div>High-risk neuroblastoma may be hard to cure.</div></li></ul></div></div><div id="CDR0000258023__46"><h2 id="_CDR0000258023__46_">Recurrent Neuroblastoma</h2><p id="CDR0000258023__47"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045862/" class="def">Recurrent</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> that has <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurred</a> (come back) after it
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has been treated. The cancer may come back in the same place or in other parts
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of the body.</p></div><div id="CDR0000258023__48"><h2 id="_CDR0000258023__48_">Treatment Option Overview</h2><div class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000258023__49">There are different types of treatment for patients with neuroblastoma. </a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__53">Children with neuroblastoma should have their treatment
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planned by a team of doctors who are experts in treating childhood cancer, especially neuroblastoma.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__209">Treatment for neuroblastoma may cause side effects.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__57">Seven types of standard treatment are used:</a></div><ul><li class="half_rhythm"><div><a href="#CDR0000258023__272">Observation</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__59">Surgery </a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__62">Radiation therapy
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</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__295">Iodine 131-MIBG therapy</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__65">Chemotherapy </a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__77">High-dose chemotherapy and radiation therapy with stem cell rescue </a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__298">Targeted therapy</a></div></li></ul></li><li class="half_rhythm"><div><a href="#CDR0000258023__72">New types of treatment are being tested in clinical trials.</a></div><ul><li class="half_rhythm"><div><a href="#CDR0000258023__261">Immunotherapy</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__276">Other drug therapy</a></div></li></ul></li><li class="half_rhythm"><div><a href="#CDR0000258023__221">Patients may want to think about taking part in a clinical trial.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__223">Patients can enter clinical trials before, during, or after starting their cancer treatment.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000258023__225">Follow-up tests may be needed.</a></div></li></ul></div><div id="CDR0000258023__49"><h3>There are different types of treatment for patients with neuroblastoma. </h3><p id="CDR0000258023__51">Different types of treatment are available for patients with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a>. Some treatments are <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044930/" class="def">standard</a> (the currently used treatment), and some
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are being tested in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a>. A treatment clinical trial is a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651211/" class="def">research study</a> meant to help
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improve current treatments or obtain information on new treatments for patients
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with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>. When clinical trials show that a new treatment is better than the
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standard treatment, the new
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treatment may become the standard treatment. </p><p id="CDR0000258023__52">Because cancer in children is rare, taking part in a clinical trial should be considered. Some clinical trials are open only to patients who have not started treatment. </p></div><div id="CDR0000258023__53"><h3>Children with neuroblastoma should have their treatment
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planned by a team of doctors who are experts in treating childhood cancer, especially neuroblastoma.</h3><p id="CDR0000258023__55">Treatment will be overseen by a
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000693555/" class="def">pediatric oncologist</a>, a doctor who specializes
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in treating children with cancer. The pediatric oncologist works with other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046245/" class="def">pediatric</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000650566/" class="def">health care providers</a> who are experts in treating children
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with neuroblastoma and who specialize
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in certain areas of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000482419/" class="def">medicine</a>. These may include the following
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000478785/" class="def">specialists</a>:</p><ul id="CDR0000258023__56"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000318823/" class="def">Pediatric surgeon</a>.</div></li><li class="half_rhythm"><div>Pediatric <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046546/" class="def">radiation oncologist</a>..</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046439/" class="def">Endocrinologist</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046267/" class="def">Neurologist</a>.</div></li><li class="half_rhythm"><div>Pediatric <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000318818/" class="def">neuropathologist</a>..</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000318819/" class="def">Neuroradiologist</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000757278/" class="def">Pediatrician</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000318821/" class="def">Pediatric nurse specialist</a>.</div></li><li class="half_rhythm"><div>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044730/" class="def">Social worker</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000690737/" class="def">Child life professional</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044716/" class="def">Psychologist</a>.</div></li></ul></div><div id="CDR0000258023__209"><h3>Treatment for neuroblastoma may cause side effects.</h3><p id="CDR0000258023__209_76">For information about <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> that begin during treatment for cancer, see our <a href="https://www.cancer.gov/about-cancer/treatment/side-effects" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Side Effects</a> page.</p><p id="CDR0000258023__210">Side effects from cancer treatment that begin after treatment and continue for months or years are called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390292/" class="def">late effects</a>. Late effects of cancer treatment may include:</p><ul id="CDR0000258023__218"><li class="half_rhythm"><div>Physical problems.</div></li><li class="half_rhythm"><div>Changes in mood, feelings, thinking, learning, or memory.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046658/" class="def">Second cancers</a> (new types of cancer). </div></li></ul><p id="CDR0000258023__208"> Some late effects may be treated or controlled. It is important that parents of children who are treated for neuroblastoma talk with their doctors about the possible late effects caused by some treatments. See the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044271/" class="def">PDQ</a> summary on <a href="/books/n/pdqcis/CDR0000373791/">Late Effects of Treatment for Childhood Cancer</a> for more information.</p></div><div id="CDR0000258023__57"><h3>Seven types of standard treatment are used:</h3><div id="CDR0000258023__272"><h4>Observation</h4><p id="CDR0000258023__274"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045981/" class="def">Observation</a> is closely <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454803/" class="def">monitoring</a> a patient's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a> without giving any treatment until <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000750109/" class="def">signs</a> or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a> appear or change.</p></div><div id="CDR0000258023__59"><h4>Surgery </h4><p id="CDR0000258023__61"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">Surgery</a> is used to treat neuroblastoma unless it has spread to other parts of the body. Depending on where the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> is, as much of the tumor as is safely possible will be removed. If the tumor cannot be removed, a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045164/" class="def">biopsy</a> may be done instead. </p></div><div id="CDR0000258023__62"><h4>Radiation therapy
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</h4><p id="CDR0000258023__64"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044971/" class="def">Radiation therapy</a> is a cancer treatment that uses high-energy <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045944/" class="def">x-rays</a> or other types of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045072/" class="def">radiation</a> to kill cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> or keep them from growing. There are two types of radiation therapy: </p><ul id="CDR0000258023__294"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046686/" class="def">External radiation therapy</a> uses a machine outside the body to send radiation toward the cancer.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046345/" class="def">Internal radiation therapy</a> uses a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046550/" class="def">radioactive</a> substance sealed in needles, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000257219/" class="def">seeds</a>, wires, or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045637/" class="def">catheters</a> that are placed directly into or near the cancer.</div></li></ul><p id="CDR0000258023__271">The way the radiation therapy is given depends on the type of cancer being treated and the child's risk group. External radiation therapy is used to treat neuroblastoma.</p></div><div id="CDR0000258023__295"><h4>Iodine 131-MIBG therapy</h4><p id="CDR0000258023__297">
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390341/" class="def">Iodine 131-MIBG</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044737/" class="def">therapy</a> is a treatment with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045855/" class="def">radioactive iodine</a>. The radioactive iodine is given through an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046682/" class="def">intravenous</a> (IV) line and enters the bloodstream which carries radiation directly to tumor cells. Radioactive iodine collects in neuroblastoma cells and kills them with the radiation that is given off. Iodine 131-MIBG therapy is sometimes used to treat high-risk neuroblastoma that comes back after initial treatment.</p></div><div id="CDR0000258023__65"><h4>Chemotherapy </h4><p id="CDR0000258023__67"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">Chemotherapy</a> is a cancer treatment that uses <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000348921/" class="def">drugs</a> to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044678/" class="def">injected</a> into a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476471/" class="def">vein</a> or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000301626/" class="def">systemic chemotherapy</a>). When chemotherapy is placed directly into the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046483/" class="def">cerebrospinal fluid</a>, an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000257523/" class="def">organ</a>, or a body <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000463703/" class="def">cavity</a> such as the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045070/" class="def">abdomen</a>, the drugs mainly affect cancer cells in those areas (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046559/" class="def">regional chemotherapy</a>). The way the chemotherapy is given depends on the type of cancer being treated and the child's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000711109/" class="def">risk group</a>.</p><p id="CDR0000258023__68">The use of two or more <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000639945/" class="def">anticancer</a> drugs is called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045650/" class="def">combination chemotherapy</a>.</p><p id="CDR0000258023__239">See <a href="https://www.cancer.gov/about-cancer/treatment/drugs/neuroblastoma" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Drugs Approved for Neuroblastoma</a> for more information.</p></div><div id="CDR0000258023__77"><h4>High-dose chemotherapy and radiation therapy with stem cell rescue </h4><p id="CDR0000258023__79">
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000346522/" class="def">High-dose chemotherapy</a> and radiation therapy with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000666718/" class="def">stem cell rescue</a> is a way of giving high <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044664/" class="def">doses</a> of chemotherapy and radiation therapy and replacing <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a>-forming cells destroyed by cancer treatment for high-risk neuroblastoma. <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046598/" class="def">Stem cells</a> (immature blood cells) are removed from the blood or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045622/" class="def">bone marrow</a> of the patient and are frozen and stored. After chemotherapy and radiation therapy are completed, the stored stem cells are thawed and given back to the patient through an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045738/" class="def">infusion</a>. These <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045738/" class="def">reinfused</a> stem cells grow into (and restore) the body's blood cells.</p><p id="CDR0000258023__279"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045768/" class="def">Maintenance therapy</a> is given after high-dose chemotherapy and radiation therapy with stem cell rescue to kill any cancer cells that may regrow and cause the disease to come back. Maintenance therapy is given for 6 months and includes the following treatments:</p><ul id="CDR0000258023__280"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045534/" class="def">Isotretinoin</a>: A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044744/" class="def">vitamin</a>-like drug that slows the cancer's ability to make more cancer cells and changes how these cells look and act. This drug is taken by mouth.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000770167/" class="def">Dinutuximab</a>: A type of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046066/" class="def">monoclonal antibody</a> therapy that uses an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044918/" class="def">antibody</a> made in the laboratory from a single type of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046356/" class="def">immune system</a> cell. Dinutuximab identifies and attaches to a substance, called GD2, on the surface of neuroblastoma cells. Once dinutuximab attaches to the GD2, a signal is sent to the immune system that a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000698772/" class="def">foreign</a> substance has been found and needs to be killed. Then the body's immune system kills the neuroblastoma cell. Dinutuximab is given by infusion. It is a type of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270742/" class="def">targeted therapy</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000423043/" class="def">Granulocyte-macrophage colony-stimulating factor</a> (GM-CSF): A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046130/" class="def">cytokine</a> that helps make more immune system cells, especially <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046374/" class="def">granulocytes</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044054/" class="def">macrophages</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045993/" class="def">white blood cells</a>), which can attack and kill cancer cells.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045256/" class="def">Interleukin-2</a> (IL-2): A type of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045729/" class="def">immunotherapy</a> that boosts the growth and activity of many immune cells, especially <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045765/" class="def">lymphocytes</a> (a type of white blood cell). Lymphocytes can attack and kill cancer cells.</div></li></ul><p id="CDR0000258023__293">See <a href="https://www.cancer.gov/about-cancer/treatment/drugs/neuroblastoma" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Drugs Approved for Neuroblastoma</a> for more information.</p></div><div id="CDR0000258023__298"><h4>Targeted therapy</h4><p id="CDR0000258023__300">Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack cancer cells with less harm to normal cells.</p><p id="CDR0000258023__305"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044833/" class="def">Tyrosine kinase inhibitors</a> are <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000653146/" class="def">small-molecule drugs</a> that go through the cell <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046294/" class="def">membrane</a> and work inside cancer cells to block signals that cancer cells need to grow and divide. <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000710948/" class="def">Crizotinib</a> is used to treat neuroblastoma that has come back after treatment.</p></div></div><div id="CDR0000258023__72"><h3>New types of treatment are being tested in clinical trials.</h3><p id="CDR0000258023__217">This summary section describes treatments that are being studied in clinical trials. It may not mention every new treatment being studied. Information about clinical trials is available from the <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCI website</a>.</p><div id="CDR0000258023__261"><h4>Immunotherapy</h4><p id="CDR0000258023__302"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045729/" class="def">Immunotherapy</a> is a treatment that uses the patient’s <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046356/" class="def">immune system</a> to fight cancer. Substances made by the body or made in a laboratory are used to boost, direct, or restore the body’s natural defenses against cancer. This type of cancer treatment is also called biotherapy or biological therapy.</p><p id="CDR0000258023__303"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000386223/" class="def">Vaccine therapy</a> uses a substance to stimulate the immune system to destroy a tumor. Vaccine therapy is being studied to treat neuroblastoma that has come back after treatment.</p></div><div id="CDR0000258023__276"><h4>Other drug therapy</h4><p id="CDR0000258023__278"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000393761/" class="def">Lenalidomide</a> is a type of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046739/" class="def">angiogenesis inhibitor</a>. It prevents the growth of new <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045020/" class="def">blood vessels</a> that are needed by a tumor to grow.</p></div></div><div id="CDR0000258023__221"><h3>Patients may want to think about taking part in a clinical trial.</h3><p id="CDR0000258023__221_23">For some patients, taking part in a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trial</a> may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044930/" class="def">standard treatment</a>.</p><p id="CDR0000258023__221_24">Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.</p><p id="CDR0000258023__221_25">Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.</p></div><div id="CDR0000258023__223"><h3>Patients can enter clinical trials before, during, or after starting their cancer treatment.</h3><p id="CDR0000258023__223_29">Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurring</a> (coming back) or reduce the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> of cancer treatment.</p><p id="CDR0000258023__223_30">Clinical trials are taking place in many parts of the country. Information about clinical trials supported by NCI can be found on NCI’s <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trials search</a> webpage. Clinical trials supported by other organizations can be found on the <a href="https://clinicaltrials.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ClinicalTrials.gov</a> website.</p></div><div id="CDR0000258023__225"><h3>Follow-up tests may be needed.</h3><p id="CDR0000258023__225_55">Some of the tests that were done to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnose</a> the cancer or to find out the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045885/" class="def">stage</a> of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.</p><p id="CDR0000258023__225_56">Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your child's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a> has changed or if the cancer has <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurred</a> (come back). These tests are sometimes called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044671/" class="def">follow-up</a> tests or check-ups.</p></div></div><div id="CDR0000258023__155"><h2 id="_CDR0000258023__155_">Treatment Options for Neuroblastoma</h2><p id="CDR0000258023__307">For information about the treatments listed below, see the <a href="#CDR0000258023__57">Treatment Option Overview</a> section.</p><div id="CDR0000258023__84"><h3>Low-Risk Neuroblastoma
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</h3><p id="CDR0000258023__85">Treatment of low-risk <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> may include the following:</p><ul id="CDR0000258023__86"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">Surgery</a> followed by <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045981/" class="def">observation</a>. </div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">Chemotherapy</a> with or without surgery, for children with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>, children whose <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> has continued to grow and cannot be removed by surgery, or children with unfavorable tumor biology.</div></li><li class="half_rhythm"><div>Observation alone for infants younger than 6 months who have small <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046678/" class="def">adrenal</a> tumors.</div></li><li class="half_rhythm"><div>Observation alone for infants who do not have <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000750109/" class="def">signs</a> or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a> of neuroblastoma.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044971/" class="def">Radiation therapy</a> to treat tumors that are causing serious problems and do not <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">respond</a> quickly to chemotherapy or surgery.</div></li><li class="half_rhythm"><div>A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trial</a> of treatment based on the tumor's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">response</a> to treatment and <a href="#CDR0000258023__192">tumor biology</a>.</div></li></ul></div><div id="CDR0000258023__88"><h3>Intermediate-Risk Neuroblastoma</h3><p id="CDR0000258023__89">Treatment of intermediate-risk <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> may include the following:</p><ul id="CDR0000258023__90"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">Chemotherapy</a> for children with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a> or to shrink a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> that cannot be removed by <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a>. Surgery may be done after chemotherapy.</div></li><li class="half_rhythm"><div>Surgery alone for infants.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045981/" class="def">Observation</a> alone for certain infants.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044971/" class="def">Radiation therapy</a> to treat tumors that are causing serious problems and do not <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">respond</a> quickly to chemotherapy or surgery.</div></li><li class="half_rhythm"><div>Radiation therapy for tumors that do not respond to other treatment.</div></li><li class="half_rhythm"><div>A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trial</a> of treatment based on the tumor's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">response</a> to treatment and <a href="#CDR0000258023__192">tumor biology</a>.</div></li></ul></div><div id="CDR0000258023__94"><h3>High-Risk Neuroblastoma
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</h3><p id="CDR0000258023__95">Treatment of high-risk <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> may include the following:</p><ul id="CDR0000258023__162"><li class="half_rhythm"><div>A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045864/" class="def">regimen</a> of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045650/" class="def">combination chemotherapy</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000666718/" class="def">stem cell rescue</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044971/" class="def">radiation therapy</a>, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046066/" class="def">monoclonal antibody</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044737/" class="def">therapy</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000770167/" class="def">dinutuximab</a>) with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045256/" class="def">interleukin-2</a> (IL-2), <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000423043/" class="def">granulocyte-macrophage colony-stimulating factor</a> (GM-CSF), and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045534/" class="def">isotretinoin</a>.</div></li></ul></div><div id="CDR0000258023__253"><h3>Stage 4S Neuroblastoma</h3><p id="CDR0000258023__254">There is no <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044930/" class="def">standard treatment</a> for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000396792/" class="def">stage 4S neuroblastoma</a> but treatment options include the following:</p><ul id="CDR0000258023__255"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045981/" class="def">Observation</a> with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046609/" class="def">supportive care</a> for certain children who have favorable <a href="#CDR0000258023__192">tumor biology</a> and do not have <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000750109/" class="def">signs</a> or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">Chemotherapy</a>, for children who have signs or symptoms of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> or unfavorable tumor biology, or for very young infants.</div></li><li class="half_rhythm"><div>A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trial</a> of treatment based on the tumor's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">response</a> to treatment and tumor biology.</div></li></ul></div><div id="CDR0000258023__114"><h3>Recurrent Neuroblastoma </h3><p id="CDR0000258023__200"><b><div class="milestone-start" id="CDR0000258023__142"></div>Patients First Treated for Low-Risk Neuroblastoma</b></p><p id="CDR0000258023__143">Treatment for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045861/" class="def">recurrent</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> that is found only in the area where the cancer first formed may include the following:</p><ul id="CDR0000258023__133"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">Surgery</a> followed by <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045981/" class="def">observation</a> or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">chemotherapy</a>.</div></li><li class="half_rhythm"><div>Chemotherapy that may be followed by surgery.</div></li></ul><p id="CDR0000258023__119">Treatment for recurrent neuroblastoma that has spread to other parts of the body may include the following:</p><ul id="CDR0000258023__120"><li class="half_rhythm"><div>Observation.</div></li><li class="half_rhythm"><div>Chemotherapy.</div></li><li class="half_rhythm"><div>Surgery followed by chemotherapy.</div></li><li class="half_rhythm"><div>Treatment as for <a href="#CDR0000258023__94">newly diagnosed high-risk neuroblastoma</a> for children older than 1 year.<div class="milestone-end"></div></div></li></ul><p id="CDR0000258023__201"><b><div class="milestone-start" id="CDR0000258023__138"></div>Patients First Treated for Intermediate-Risk Neuroblastoma</b></p><p id="CDR0000258023__134">Treatment for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045862/" class="def">recurrent</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> that is found only in the area where the cancer first formed may include the following:</p><ul id="CDR0000258023__236"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">Surgery</a> that may be followed by <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">chemotherapy</a>.</div></li><li class="half_rhythm"><div>Treatment as for <a href="#CDR0000258023__94">newly diagnosed high-risk neuroblastoma</a> for neuroblastoma that has spread to other parts of the body.</div></li></ul><p id="CDR0000258023__135">Recurrent neuroblastoma that has spread to other parts of the body is treated the same way as <a href="#CDR0000258023__94">newly diagnosed high-risk neuroblastoma</a>.<div class="milestone-end"></div></p><p id="CDR0000258023__202"><b><div class="milestone-start" id="CDR0000258023__139"></div>Patients First Treated for High-Risk Neuroblastoma</b></p><p id="CDR0000258023__245">Treatment for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045862/" class="def">recurrent</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> may include the following:</p><ul id="CDR0000258023__246"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045650/" class="def">Combination chemotherapy</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390341/" class="def">Iodine 131-MIBG</a> therapy to relieve <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a> and improve <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045417/" class="def">quality of life</a>. It may be given alone or in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000688810/" class="def">combination</a> with other therapy, or before <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000666718/" class="def">stem cell rescue</a>.</div></li><li class="half_rhythm"><div>A second course of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000346522/" class="def">high-dose chemotherapy</a> and stem cell rescue.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044833/" class="def">Tyrosine kinase inhibitor</a> therapy (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000710948/" class="def">crizotinib</a>) for patients with changes in the <i><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000721252/" class="def">ALK</a></i> gene.</div></li></ul><p id="CDR0000258023__247">Because there is no <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044930/" class="def">standard treatment</a> for recurrent neuroblastoma in patients first treated for high-risk neuroblastoma, patients may want to consider a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trial</a>. For information about clinical trials, please see the <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCI website</a>.<div class="milestone-end"></div></p><p id="CDR0000258023__242"><b><div class="milestone-start" id="CDR0000258023__241"></div>Patients with Recurrent CNS Neuroblastoma </b></p><p id="CDR0000258023__243">Treatment for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> that <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurs</a> (comes back) in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046481/" class="def">central nervous system</a> (CNS; brain and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000340937/" class="def">spinal cord</a>) may include the following:</p><ul id="CDR0000258023__244"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">Surgery</a> to remove the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> in the CNS followed by <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044971/" class="def">radiation therapy</a>.</div></li><li class="half_rhythm"><div>A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trial</a> of a new <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044737/" class="def">therapy</a>.<div class="milestone-end"></div></div></li></ul><p id="CDR0000258023__257"><b><div class="milestone-start" id="CDR0000258023__256"></div>Treatments Being Studied for Progressive/Recurrent Neuroblastoma</b></p><p id="CDR0000258023__258">Some of the treatments being studied in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a> for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045418/" class="def">neuroblastoma</a> that <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurs</a> (comes back) or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045850/" class="def">progresses</a> (grows, spreads, or does not <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044085/" class="def">respond</a> to treatment) include the following:</p><ul id="CDR0000258023__259"><li class="half_rhythm"><div>Checking a sample of the patient's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> for certain <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045693/" class="def">gene</a> changes. The type of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270742/" class="def">targeted therapy</a> that will be given to the patient depends on the type of gene change.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000393761/" class="def"> Lenalidomide</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046066/" class="def">monoclonal antibody</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044737/" class="def">therapy</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000770167/" class="def">dinutuximab</a>) with or without <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045534/" class="def">isotretinoin</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390341/" class="def">Iodine 131-MIBG</a> therapy given alone or with other anticancer drugs.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045729/" class="def">Immunotherapy</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000386223/" class="def">vaccine therapy</a>).</div></li><li class="half_rhythm"><div>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044833/" class="def">Tyrosine kinase inhibitor</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000710948/" class="def">crizotinib</a>) and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045650/" class="def">combination chemotherapy</a>.<div class="milestone-end"></div></div></li></ul><p id="CDR0000258023__TrialSearch_155_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div></div><div id="CDR0000258023__212"><h2 id="_CDR0000258023__212_">To Learn More About Neuroblastoma</h2><p id="CDR0000258023__213">For more information from the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044266/" class="def">National Cancer Institute</a> about neuroblastoma, see the following:</p><ul id="CDR0000258023__240"><li class="half_rhythm"><div><a href="https://www.cancer.gov/types/neuroblastoma" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Neuroblastoma Home Page</a></div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/CDR0000062849/">Neuroblastoma Screening</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/diagnosis-staging/ct-scans-fact-sheet" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Computed Tomography (CT) Scans and Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/treatment/drugs/neuroblastoma" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Drugs Approved for Neuroblastoma</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Targeted Cancer Therapies</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/bio-therapies-fact-sheet" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Biological Therapies for Cancer</a></div></li><li class="half_rhythm"><div><a href="http://www.nant.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">New Approaches to Neuroblastoma Therapy (NANT)</a></div></li></ul><p id="CDR0000258023__212_44">For more childhood <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> information and other general cancer resources, see the following:</p><ul id="CDR0000258023__212_45"><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">About Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/types/childhood-cancers" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Childhood Cancers</a>
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</div></li><li class="half_rhythm"><div><a href="http://www.curesearch.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">CureSearch for Children's Cancer</a>
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</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/CDR0000373791/">Late Effects of Treatment for Childhood Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/types/aya" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Adolescents and Young Adults with Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/publications/patient-education/guide-for-parents" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Children with Cancer: A Guide for Parents</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/types/childhood-cancers/child-adolescent-cancers-fact-sheet" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cancer in Children and Adolescents</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/diagnosis-staging/staging" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Staging</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/coping" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Coping with Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/coping/questions" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Questions to Ask Your Doctor about Cancer</a></div></li><li class="half_rhythm"><div><a href="https://cancercontrol.cancer.gov/ocs/resources/survivors.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">For Survivors and Caregivers</a>
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</div></li></ul></div><div id="CDR0000258023__AboutThis_1"><h2 id="_CDR0000258023__AboutThis_1_">About This PDQ Summary</h2><div id="CDR0000258023__AboutThis_2"><h3>About PDQ</h3><p id="CDR0000258023__AboutThis_3">Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in <a href="https://www.cancer.gov/espanol/publicaciones/pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Spanish</a>.</p><p id="CDR0000258023__AboutThis_4">PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.</p></div><div id="CDR0000258023__AboutThis_5"><h3>Purpose of This Summary</h3><p id="CDR0000258023__AboutThis_6">This PDQ cancer information summary has current information about the treatment of neuroblastoma. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p></div><div id="CDR0000258023__AboutThis_7"><h3>Reviewers and Updates</h3><p id="CDR0000258023__AboutThis_8">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change.
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</p><p id="CDR0000258023__AboutThis_9">The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the <a href="http://www.cancer.gov/publications/pdq/editorial-boards/pediatric-treatment" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PDQ Pediatric Treatment Editorial Board</a>.
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</p></div><div id="CDR0000258023__AboutThis_10"><h3>Clinical Trial Information</h3><p id="CDR0000258023__AboutThis_11">A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
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</p><p id="CDR0000258023__AboutThis_12">Clinical trials are listed in PDQ and can be found online at <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCI's website</a>. Many cancer doctors who take part in clinical trials are also listed in PDQ. For more information, call the Cancer Information Service 1-800-4-CANCER (1-800-422-6237).
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</p></div><div id="CDR0000258023__AboutThis_13"><h3>Permission to Use This Summary</h3><p id="CDR0000258023__AboutThis_14">PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”
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</p><p id="CDR0000258023__AboutThis_15">The best way to cite this PDQ summary is:</p><p id="CDR0000258023__AboutThis_21">PDQ® Pediatric Treatment Editorial Board. PDQ Neuroblastoma Treatment. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: <a href="https://www.cancer.gov/types/neuroblastoma/patient/neuroblastoma-treatment-pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www.cancer.gov/types/neuroblastoma/patient/neuroblastoma-treatment-pdq</a>. Accessed <MM/DD/YYYY>. [PMID: 26389278]</p><p id="CDR0000258023__AboutThis_16">Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in <a href="https://visualsonline.cancer.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Visuals Online</a>. Visuals Online is a collection of more than 2,000 scientific images.
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</p></div><div id="CDR0000258023__AboutThis_17"><h3>Disclaimer</h3><p id="CDR0000258023__AboutThis_18">The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the <a href="https://www.cancer.gov/about-cancer/managing-care" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Managing Cancer Care</a> page.</p></div><div id="CDR0000258023__AboutThis_19"><h3>Contact Us</h3><p id="CDR0000258023__AboutThis_20">More information about contacting us or receiving help with the Cancer.gov website can be found on our <a href="https://www.cancer.gov/contact" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Contact Us for Help</a> page. Questions can also be submitted to Cancer.gov through the website’s <a href="https://www.cancer.gov/contact/email-us" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">E-mail Us</a>.</p></div></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK65838</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/26389278" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">26389278</a></span></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK65838.13/?report=reader">PubReader</a></li><li><a href="/books/NBK65838.13/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK65838" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK65838" style="display:none" title="Cite this Page"><div class="bk_tt">PDQ Pediatric Treatment Editorial Board. Neuroblastoma Treatment (PDQ®): Patient Version. 2018 Mar 16. In: PDQ Cancer Information Summaries [Internet]. 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ref="log$=inpage&link_id=inpage">General Information About Neuroblastoma</a></li><li><a href="#CDR0000258023__21" ref="log$=inpage&link_id=inpage">Stages of Neuroblastoma</a></li><li><a href="#CDR0000258023__46" ref="log$=inpage&link_id=inpage">Recurrent Neuroblastoma</a></li><li><a href="#CDR0000258023__48" ref="log$=inpage&link_id=inpage">Treatment Option Overview</a></li><li><a href="#CDR0000258023__155" ref="log$=inpage&link_id=inpage">Treatment Options for Neuroblastoma</a></li><li><a href="#CDR0000258023__212" ref="log$=inpage&link_id=inpage">To Learn More About Neuroblastoma</a></li><li><a href="#CDR0000258023__AboutThis_1" ref="log$=inpage&link_id=inpage">About This PDQ Summary</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related publications</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" 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Summari...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Retinoblastoma Treatment (PDQ®): Patient Version.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">PDQ Pediatric Treatment Editorial Board. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">PDQ Cancer Information Summaries. 2002</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/31909939" ref="ordinalpos=1&linkpos=2&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Childhood Chordoma (PDQ®): Patient Version.</a><span class="source">[PDQ Cancer 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class="source">[PDQ Cancer Information Summari...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Childhood Melanoma Treatment (PDQ®): Patient Version.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">PDQ Pediatric Treatment Editorial Board. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">PDQ Cancer Information Summaries. 2002</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/26389322" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Cancer Pain (PDQ®): Patient 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