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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/pdqcis/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" alt="Cover of PDQ Cancer Information Summaries" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>PDQ Cancer Information Summaries [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK65730_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK65730_dtls__"><div>Bethesda (MD): <a href="http://www.cancer.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Cancer Institute (US)</a>; 2002-.</div></div><div class="half_rhythm"></div><div class="bk_noprnt"><form method="get" action="/books/n/pdqcis/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK65730_"><span class="title" itemprop="name">Stomach (Gastric) Cancer Screening (PDQ®)</span></h1><div class="subtitle whole_rhythm">Health Professional Version</div><p class="contrib-group"><span itemprop="author">PDQ Screening and Prevention Editorial Board</span>.</p><p class="small">Published online: April 1, 2016.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><p id="CDR0000062757__94">This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about stomach (gastric) cancer screening. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.</p><p id="CDR0000062757__95">This summary is reviewed regularly and updated as necessary by the PDQ Screening and Prevention Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).</p></div><div id="CDR0000062757__1"><h2 id="_CDR0000062757__1_"> Overview</h2><p id="CDR0000062757__2">Note: Separate PDQ summaries on <a href="/books/n/pdqcis/CDR0000062830/">Stomach (Gastric) Cancer Prevention</a>, <a href="/books/n/pdqcis/CDR0000062911/">Gastric Cancer
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Treatment</a>, and <a href="/books/n/pdqcis/CDR0000304747/">Levels of Evidence for Cancer Screening and Prevention Studies</a> are also available.
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</p><div id="CDR0000062757__22"><h3>Inadequate Evidence of Benefit Associated with Screening</h3><div id="CDR0000062757__96"><h4>Barium-meal photofluorography, gastric endoscopy, and serum pepsinogen</h4><p id="CDR0000062757__97">Based on fair evidence, screening with barium-meal photofluorography, gastric endoscopy, or serum pepsinogen would not result in a decrease in mortality from gastric cancer in areas with relatively low incidence of the disease, such as the United States.[<a class="bk_pop" href="#CDR0000062757_rl_1_1">1</a>-<a class="bk_pop" href="#CDR0000062757_rl_1_4">4</a>]</p><p id="CDR0000062757__98"><b>Magnitude of Effect: Fair evidence for no reduction in mortality.</b></p><ul id="CDR0000062757__99" class="simple-list"><li class="half_rhythm"><div><b>Study Design</b>: Evidence obtained from case-control and cohort studies, primarily from high-risk areas such as Eastern Asia.</div></li><li class="half_rhythm"><div><b>Internal Validity</b>: Fair.</div></li><li class="half_rhythm"><div><b>Consistency</b>: Poor in prospective studies.[<a class="bk_pop" href="#CDR0000062757_rl_1_5">5</a>]</div></li><li class="half_rhythm"><div><b>External Validity</b>: Poor. Studies on populations in high-risk areas may not be applicable to low-risk areas such as the United States.</div></li></ul><div id="CDR0000062757__108"><h5>Harms</h5><p id="CDR0000062757__109">Based on solid evidence, screening would result in uncommon but serious side effects associated with endoscopy, which may include perforation, cardiopulmonary events, aspiration pneumonia, and bleeding requiring hospitalization.</p><p id="CDR0000062757__102"><b>Magnitude of Effect: Solid evidence for rare but serious harms.</b></p><ul id="CDR0000062757__103" class="simple-list"><li class="half_rhythm"><div><b>Study Design</b>: Evidence obtained from screening programs and from case series.</div></li><li class="half_rhythm"><div><b>Internal Validity</b>: Fair.</div></li><li class="half_rhythm"><div><b>Consistency</b>: Inadequate evidence.</div></li><li class="half_rhythm"><div><b>External Validity</b>: Poor.</div></li></ul></div></div></div><div id="CDR0000062757_rl_1"><h3>References</h3><ol><li><div class="bk_ref" id="CDR0000062757_rl_1_1">Hirayama T, Hisamichi S, Fujimoto I, et al.: Screening for gastric cancer. In: Miller AB, ed.: Screening for Cancer. New York, NY: Academic Press, 1985, pp 367-376.</div></li><li><div class="bk_ref" id="CDR0000062757_rl_1_2">Tytgat GN, Mathus-Vliegen EM, Offerhaus J: Value of endoscopy in the surveillance of high-risk groups for gastrointestinal cancer. In: Sherlock P, Morson BC, Barbara L, et al., eds.: Precancerous Lesions of the Gastrointestinal Tract. New York, NY: Raven Press, 1983, pp 305-318.</div></li><li><div class="bk_ref" id="CDR0000062757_rl_1_3">Riecken B, Pfeiffer R, Ma JL, et al.: No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. Prev Med 34 (1): 22-8, 2002. [<a href="https://pubmed.ncbi.nlm.nih.gov/11749093" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11749093</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_1_4">Kitahara F, Kobayashi K, Sato T, et al.: Accuracy of screening for gastric cancer using serum pepsinogen concentrations. Gut 44 (5): 693-7, 1999. [<a href="/pmc/articles/PMC1727514/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1727514</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/10205207" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10205207</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_1_5">Leung WK, Wu MS, Kakugawa Y, et al.: Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol 9 (3): 279-87, 2008. [<a href="https://pubmed.ncbi.nlm.nih.gov/18308253" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18308253</span></a>]</div></li></ol></div></div><div id="CDR0000062757__6"><h2 id="_CDR0000062757__6_">Description of the Evidence</h2><div id="CDR0000062757__64"><h3>Background</h3><div id="CDR0000062757__65"><h4>Incidence and mortality</h4><p id="CDR0000062757__85">In 2016, it is estimated that 26,370 Americans will be diagnosed with
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gastric cancer and 10,730 will die of it.[<a class="bk_pop" href="#CDR0000062757_rl_6_1">1</a>] Two-thirds of people diagnosed with gastric cancer are older than 66 years. Gastric cancer is the fourth most common cancer in the world. The disease is much more common
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in other countries, principally Japan, Central Europe, Scandinavia, Hong Kong,
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South and Central America, the Soviet Union, China, and Korea. Gastric cancer is
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a major cause of death worldwide, especially in developing countries.[<a class="bk_pop" href="#CDR0000062757_rl_6_2">2</a>]</p><p id="CDR0000062757__86">The
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major type of gastric cancer is adenocarcinoma (95%). The remaining malignant tumors
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include lymphomas, sarcomas, carcinoid tumors and other rare types. Distinguishing the common adenocarcinoma from the uncommon lymphoma may sometimes be difficult but is important, due to major differences in staging, treatment, and prognosis.[<a class="bk_pop" href="#CDR0000062757_rl_6_3">3</a>] Gastric adenocarcinomas
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can be further categorized into an intestinal type and a diffuse type.[<a class="bk_pop" href="#CDR0000062757_rl_6_4">4</a>]
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Intestinal-type lesions are frequently ulcerative and occur in the distal
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stomach more often than the diffuse type. Diffuse-type lesions are associated with a
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worse prognosis than the intestinal type. The intestinal type tends to
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be predominant in geographic regions with a high incidence of gastric carcinoma.
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The decline in the incidence of gastric cancer worldwide is largely due to a
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decrease in the number of intestinal-type lesions.[<a class="bk_pop" href="#CDR0000062757_rl_6_5">5</a>]</p></div></div><div id="CDR0000062757__9"><h3>Risk Factors</h3><p id="CDR0000062757__10">The incidence of gastric cancer in the United States has decreased fourfold since
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1930 to approximately seven cases per 100,000 people.[<a class="bk_pop" href="#CDR0000062757_rl_6_6">6</a>] The reasons for this
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striking decrease in incidence are not fully understood but are suspected to be related to
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improved storage of food and changes in diet, such as decreased salt intake. Some populations of Americans are at elevated risk, including elderly patients with atrophic gastritis or pernicious anemia, patients with sporadic gastric adenomas,[<a class="bk_pop" href="#CDR0000062757_rl_6_7">7</a>] familial adenomatous polyposis,[<a class="bk_pop" href="#CDR0000062757_rl_6_8">8</a>] or hereditary nonpolyposis colon cancer,[<a class="bk_pop" href="#CDR0000062757_rl_6_9">9</a>] and immigrant ethnic populations from countries with high rates of gastric carcinoma.[<a class="bk_pop" href="#CDR0000062757_rl_6_10">10</a>,<a class="bk_pop" href="#CDR0000062757_rl_6_11">11</a>]</p><p id="CDR0000062757__68">
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Risk factors for gastric cancer include the presence of precursor conditions
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such as chronic atrophic gastritis and intestinal metaplasia, pernicious
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anemia, and gastric adenomatous polyps. Genetic and environmental factors
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include a family history of gastric cancer; low consumption of fruits and
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vegetables; consumption of salted, smoked, or poorly preserved foods; and
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cigarette smoking.[<a class="bk_pop" href="#CDR0000062757_rl_6_12">12</a>
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,<a class="bk_pop" href="#CDR0000062757_rl_6_13">13</a>] There is consistent evidence that <i>Helicobacter pylori</i>
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infection of the stomach is strongly associated with both the initiation and promotion
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of carcinoma of the gastric body and antrum, and of gastric lymphoma.[<a class="bk_pop" href="#CDR0000062757_rl_6_14">14</a>-<a class="bk_pop" href="#CDR0000062757_rl_6_16">16</a>] The International Agency for Research on Cancer (IARC) classifies <i>H. pylori</i> infection as a cause of noncardia gastric carcinoma and low-grade B-cell mucosa-associated lymphatic tissue gastric lymphoma (i.e., a Group 1 human carcinogen).[<a class="bk_pop" href="#CDR0000062757_rl_6_17">17</a>,<a class="bk_pop" href="#CDR0000062757_rl_6_18">18</a>] Compared with the general population,
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people with duodenal ulcer disease may have a lower risk of gastric cancer.[<a class="bk_pop" href="#CDR0000062757_rl_6_19">19</a>]
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</p></div><div id="CDR0000062757__69"><h3>Inadequate Evidence of Benefit Associated With Screening</h3><p id="CDR0000062757__70">Several screening techniques, including barium-meal photofluorography, gastric endoscopy, and serum pepsinogen have been proposed as screening methods for the early detection of gastric cancer. No randomized trials evaluating the impact of screening on mortality from gastric cancer have been reported.[<a class="bk_pop" href="#CDR0000062757_rl_6_13">13</a>,<a class="bk_pop" href="#CDR0000062757_rl_6_20">20</a>] Even in very high-risk areas, the positive predictive value (PPV) of the screening tests may be very low. In a screening program of 17,647 men aged 40 to 60 years in Wakayama City, Japan, the PPV of combined serum pepsinogen and barium meal with digital radiography over the 7-year period was 0.85%.[<a class="bk_pop" href="#CDR0000062757_rl_6_21">21</a>] The positive test rates were 19.5% for serum pepsinogen and 22.5% for radiography, with a cancer detection rate of 0.28%. Over the 7-year period, there was no reduction in gastric cancer mortality compared with an age-matched surrounding population. </p><div id="CDR0000062757__71"><h4>Barium-meal gastric photofluorography</h4><p id="CDR0000062757__72">A national program of population-based screening for gastric cancer using barium-meal photofluorography has been ongoing since the 1960s in Japan. Participation rates have been in the range of only 10% to 20%.[<a class="bk_pop" href="#CDR0000062757_rl_6_13">13</a>,<a class="bk_pop" href="#CDR0000062757_rl_6_21">21</a>] Although there has been a coincident decrease in mortality from gastric cancer in Japan, mortality rates have been decreasing in many developed countries despite the lack of screening programs. Case-control studies from Japan show decreases in gastric mortality in people who have undergone screening, but results from prospective studies were not consistent.[<a class="bk_pop" href="#CDR0000062757_rl_6_13">13</a>,<a class="bk_pop" href="#CDR0000062757_rl_6_20">20</a>]</p><p id="CDR0000062757__73">A pilot study of community-based photofluorography was conducted in Costa Rica using the same techniques as those used in Japan’s national program (with consultation from Japanese experts).[<a class="bk_pop" href="#CDR0000062757_rl_6_22">22</a>] People were invited by letter from a population registry to attend two rounds of screening, and a total of 6,200 eligible screened participants (of a planned 12,000) were analyzed. Their gastric cancer mortality from 2 to 7 years after screening was compared with four control groups that had not been invited to be screened, and the relative risk was about 0.5 (no p-value reported). The study was, however, prone to strong biases, including selection bias, and likely differential exclusion of people with previously diagnosed gastric cancer favoring the screened population. In addition, unlike the community controls, patients diagnosed with gastric cancer through the screening program were treated at a single referral center. The PPV of a suspicious fluorograph was 3%; the specificity in the two rounds was 67% and 80%; and the positivity rates were 34% and 20%. Despite the authors’ belief that their results provided substantial evidence that routine screening would decrease gastric cancer mortality, they concluded that the costs of screening with photofluorography would be far too high in their country.</p><p id="CDR0000062757__74">A screening study was begun in Venezuela in 1980, using radiographic fluorography.[<a class="bk_pop" href="#CDR0000062757_rl_6_23">23</a>] The efficacy of this program in reducing mortality from stomach cancer was evaluated by means of a case-control study, and there was no detectable reduction in mortality from gastric cancer.</p></div><div id="CDR0000062757__75"><h4>Gastric endoscopy</h4><p id="CDR0000062757__76">Endoscopy appears to be more sensitive than photofluorography for the detection of gastric cancer.[<a class="bk_pop" href="#CDR0000062757_rl_6_24">24</a>] Time-trend analysis and case-control studies of gastric endoscopy suggest a twofold decrease in gastric cancer mortality in screened versus unscreened individuals;[<a class="bk_pop" href="#CDR0000062757_rl_6_25">25</a>-<a class="bk_pop" href="#CDR0000062757_rl_6_29">29</a>] however, this stands in contrast to studies of stronger design.</p><p id="CDR0000062757__77">A cohort study of endoscopic screening was conducted in Linqu County, China, where gastric cancer rates are high, in which 4,394 adult residents aged 35 to 64 years were screened. Individuals were screened at an average of 4.5-year intervals, except for a high-risk subset (689 individuals) that was screened 2 years after the initial examination. Of the 85 cases of gastric cancer occurring in the cohort, 58 were detected with screening. No impact on gastric cancer mortality was observed among screened individuals. The standardized mortality ratio (SMR) for gastric cancer 10 years after the initial screen was 1.01 (95% confidence interval, 0.72–1.37). The SMR for all-cause mortality was significantly lower among participants because individuals with hypertension, liver disease, and chronic obstructive pulmonary disease were not eligible to participate.[<a class="bk_pop" href="#CDR0000062757_rl_6_30">30</a>] The data were observational, and not primarily collected to evaluate the effect of screening on gastric cancer mortality. In addition, the intervals between screens may have been too long.</p></div><div id="CDR0000062757__78"><h4>Serum pepsinogen</h4><p id="CDR0000062757__79">There are no studies evaluating the effect of screening with serum pepsinogen on gastric cancer mortality, and there are important limitations to its use as a screening test. Low serum pepsinogen levels indicate the presence of atrophic gastritis and are therefore applicable to the detection of presumed precursors for intestinal type gastric cancer rather than the diffuse type.[<a class="bk_pop" href="#CDR0000062757_rl_6_21">21</a>] In addition, there are no standard cut-off values of abnormality.[<a class="bk_pop" href="#CDR0000062757_rl_6_13">13</a>,<a class="bk_pop" href="#CDR0000062757_rl_6_31">31</a>] Finally, eradication of <i>H. pylori</i> and use of proton pump inhibitors for the management of indigestion change pepsinogen levels, making interpretation of results difficult in the setting of widespread use of these interventions.[<a class="bk_pop" href="#CDR0000062757_rl_6_13">13</a>,<a class="bk_pop" href="#CDR0000062757_rl_6_21">21</a>]</p><p id="CDR0000062757__80">In Japan, measurement of serum pepsinogen levels I and II (PGI and PGII) in 5,113 subjects also screened by endoscopy (13 gastric cancers detected), used cut-off points for identifying risk for gastric cancer of less than 70 ng/mL for PGI and less than 3 ng/mL for the PGI:PGII ratio. This combination provided a sensitivity of 84.6%, a specificity of 73.5%, a PPV of 0.81%, and a negative predictive value of 99.6%.[<a class="bk_pop" href="#CDR0000062757_rl_6_32">32</a>]</p></div><div id="CDR0000062757__81"><h4>Clinical considerations for high risk groups
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</h4><p id="CDR0000062757__82">There may be justification for screening some populations of Americans at
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higher risk, although there is considerable discussion about how much incidence
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would make the examination worthwhile. Potential subgroups might include
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elderly patients with atrophic gastritis or pernicious anemia, patients with partial
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gastrectomy,[<a class="bk_pop" href="#CDR0000062757_rl_6_33">33</a>] patients with the diagnosis of sporadic adenomas,[<a class="bk_pop" href="#CDR0000062757_rl_6_7">7</a>]
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familial adenomatous polyposis,[<a class="bk_pop" href="#CDR0000062757_rl_6_8">8</a>] or hereditary nonpolyposis colon cancer,[<a class="bk_pop" href="#CDR0000062757_rl_6_9">9</a>] and immigrant ethnic populations from countries with high
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rates of gastric carcinoma.[<a class="bk_pop" href="#CDR0000062757_rl_6_10">10</a>,<a class="bk_pop" href="#CDR0000062757_rl_6_11">11</a>]</p></div></div><div id="CDR0000062757__83"><h3>Evidence of Harm Associated With Screening</h3><p id="CDR0000062757__84">Harms of routine screening for gastric cancer are poorly quantitated or reported, and derive chiefly from screening experiences in very high-risk areas such as Japan.[<a class="bk_pop" href="#CDR0000062757_rl_6_20">20</a>] The most frequent harm is the occurrence of false-positive tests.[<a class="bk_pop" href="#CDR0000062757_rl_6_21">21</a>] Exposure to the low doses of radiation (about 0.6 mSv in photofluorography) carries a theoretical but poorly quantified risk of carcinogenesis. Additional rare complications of screening may include adverse effects of premedication (used for endoscopy and sometimes photofluorography), and bleeding or perforation from endoscopy.[<a class="bk_pop" href="#CDR0000062757_rl_6_20">20</a>] As with any screening test, there is a possibility of overdiagnosis with attendant overtreatment. Since harms such as perforation and bleeding may vary with the experience of the screening center, they may be higher in populations at low risk for gastric cancer, such as the United States, than in mass screening programs in Japan.</p></div><div id="CDR0000062757_rl_6"><h3>References</h3><ol><li><div class="bk_ref" id="CDR0000062757_rl_6_1">American Cancer Society: Cancer Facts and Figures 2016. Atlanta, Ga: American Cancer Society, 2016. <a href="http://www.cancer.org/acs/groups/content/@research/documents/document/acspc-047079.pdf" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">Available online</a>. Last accessed December 8, 2016.</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_2">Torre LA, Bray F, Siegel RL, et al.: Global cancer statistics, 2012. CA Cancer J Clin 65 (2): 87-108, 2015. [<a href="https://pubmed.ncbi.nlm.nih.gov/25651787" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25651787</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_3">Pisters PWT, Kelsen DP, Tepper JE: Cancer of the stomach. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds.: Cancer: Principles and Practice of Oncology. Vols. 1 & 2. 8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2008, pp 1043-1079.</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_4">Lauren P: The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma: an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64(1): 31-49, 1965. 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Am J Epidemiol 144 (2): 142-9, 1996. [<a href="https://pubmed.ncbi.nlm.nih.gov/8678045" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8678045</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_17">IARC Working Group on the Evaluation of Carcinogenic Risks to Humans: A review of human carcinogens--Part B: biological agents. Volume 100. Lyon, France: IARC Press, 2011.</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_18">Bouvard V, Baan R, Straif K, et al.: A review of human carcinogens--Part B: biological agents. Lancet Oncol 10 (4): 321-2, 2009. [<a href="https://pubmed.ncbi.nlm.nih.gov/19350698" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19350698</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_19">Hansson LE, Nyrén O, Hsing AW, et al.: The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med 335 (4): 242-9, 1996. [<a href="https://pubmed.ncbi.nlm.nih.gov/8657240" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8657240</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_20">Hamashima C, Shibuya D, Yamazaki H, et al.: The Japanese guidelines for gastric cancer screening. Jpn J Clin Oncol 38 (4): 259-67, 2008. [<a href="https://pubmed.ncbi.nlm.nih.gov/18344316" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18344316</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_21">Ohata H, Oka M, Yanaoka K, et al.: Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography. Cancer Sci 96 (10): 713-20, 2005. [<a href="https://pubmed.ncbi.nlm.nih.gov/16232204" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16232204</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_22">Rosero-Bixby L, Sierra R: X-ray screening seems to reduce gastric cancer mortality by half in a community-controlled trial in Costa Rica. Br J Cancer 97 (7): 837-43, 2007. [<a href="/pmc/articles/PMC2360405/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2360405</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/17912238" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17912238</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_23">Pisani P, Oliver WE, Parkin DM, et al.: Case-control study of gastric cancer screening in Venezuela. Br J Cancer 69 (6): 1102-5, 1994. [<a href="/pmc/articles/PMC1969457/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1969457</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/8198977" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8198977</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_24">Tashiro A, Sano M, Kinameri K, et al.: Comparing mass screening techniques for gastric cancer in Japan. World J Gastroenterol 12 (30): 4873-4, 2006. [<a href="/pmc/articles/PMC4087623/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4087623</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/16937471" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16937471</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_25">Murakami R, Tsukuma H, Ubukata T, et al.: Estimation of validity of mass screening program for gastric cancer in Osaka, Japan. Cancer 65 (5): 1255-60, 1990. [<a href="https://pubmed.ncbi.nlm.nih.gov/2302674" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2302674</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_26">Kampschöer GH, Fujii A, Masuda Y: Gastric cancer detected by mass survey. Comparison between mass survey and outpatient detection. Scand J Gastroenterol 24 (7): 813-7, 1989. [<a href="https://pubmed.ncbi.nlm.nih.gov/2799284" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2799284</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_27">Oshima A, Hirata N, Ubukata T, et al.: Evaluation of a mass screening program for stomach cancer with a case-control study design. Int J Cancer 38 (6): 829-33, 1986. [<a href="https://pubmed.ncbi.nlm.nih.gov/3793262" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3793262</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_28">Hirayama T, Hisamichi S, Fujimoto I, et al.: Screening for gastric cancer. In: Miller AB, ed.: Screening for Cancer. New York, NY: Academic Press, 1985, pp 367-376.</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_29">Tytgat GN, Mathus-Vliegen EM, Offerhaus J: Value of endoscopy in the surveillance of high-risk groups for gastrointestinal cancer. In: Sherlock P, Morson BC, Barbara L, et al., eds.: Precancerous Lesions of the Gastrointestinal Tract. New York, NY: Raven Press, 1983, pp 305-318.</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_30">Riecken B, Pfeiffer R, Ma JL, et al.: No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. Prev Med 34 (1): 22-8, 2002. [<a href="https://pubmed.ncbi.nlm.nih.gov/11749093" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11749093</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_31">Yanaoka K, Oka M, Mukoubayashi C, et al.: Cancer high-risk subjects identified by serum pepsinogen tests: outcomes after 10-year follow-up in asymptomatic middle-aged males. Cancer Epidemiol Biomarkers Prev 17 (4): 838-45, 2008. [<a href="https://pubmed.ncbi.nlm.nih.gov/18398025" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18398025</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_32">Kitahara F, Kobayashi K, Sato T, et al.: Accuracy of screening for gastric cancer using serum pepsinogen concentrations. Gut 44 (5): 693-7, 1999. [<a href="/pmc/articles/PMC1727514/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1727514</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/10205207" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10205207</span></a>]</div></li><li><div class="bk_ref" id="CDR0000062757_rl_6_33">Staël von Holstein C, Eriksson S, Huldt B, et al.: Endoscopic screening during 17 years for gastric stump carcinoma. A prospective clinical trial. Scand J Gastroenterol 26 (10): 1020-6, 1991. [<a href="https://pubmed.ncbi.nlm.nih.gov/1947767" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1947767</span></a>]</div></li></ol></div></div><div id="CDR0000062757__15"><h2 id="_CDR0000062757__15_">Changes to This Summary (04/01/2016)</h2><p id="CDR0000062757__17">The PDQ cancer information summaries are reviewed regularly and updated as
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new information becomes available. This section describes the latest
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changes made to this summary as of the date above.</p><p id="CDR0000062757__104"><b><a href="#CDR0000062757__1">Overview</a></b></p><p id="CDR0000062757__105">Added <a href="#CDR0000062757__22">Inadequate Evidence of Benefit Associated with Screening</a> as a new subsection.</p><p id="CDR0000062757__92"><b><a href="#CDR0000062757__6">Description of the Evidence</a></b></p><p id="CDR0000062757__93">Updated <a href="#CDR0000062757__85">statistics</a> with estimated new cases and deaths for 2016 (cited American Cancer Society as reference 1). Also added text to state that gastric cancer is the fourth most common cancer in the world (cited Torre et al. as reference 2).</p><p id="CDR0000062757__106">Added Henson et al. as <a href="#CDR0000062757__86">reference 5</a>.</p><p id="CDR0000062757__107">Added National Cancer Institute as <a href="#CDR0000062757__10">reference 6</a>.</p><p id="CDR0000062757__disclaimerHP_3">This summary is written and maintained by the <a href="http://www.cancer.gov/publications/pdq/editorial-boards/screening-prevention" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PDQ Screening and Prevention Editorial Board</a>, which is
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editorially independent of NCI. The summary reflects an independent review of
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the literature and does not represent a policy statement of NCI or NIH. More
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information about summary policies and the role of the PDQ Editorial Boards in
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maintaining the PDQ summaries can be found on the <a href="#CDR0000062757__AboutThis_1">About This PDQ Summary</a> and <a href="http://www.cancer.gov/publications/pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PDQ® - NCI's Comprehensive Cancer Database</a> pages.
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</p></div><div id="CDR0000062757__AboutThis_1"><h2 id="_CDR0000062757__AboutThis_1_">About This PDQ Summary</h2><div id="CDR0000062757__AboutThis_2"><h3>Purpose of This Summary</h3><p id="CDR0000062757__AboutThis_3">This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about stomach (gastric) cancer screening. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.</p></div><div id="CDR0000062757__AboutThis_4"><h3>Reviewers and Updates</h3><p id="CDR0000062757__AboutThis_5">This summary is reviewed regularly and updated as necessary by the <a href="http://www.cancer.gov/publications/pdq/editorial-boards/screening-prevention" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PDQ Screening and Prevention Editorial Board</a>, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).</p><p id="CDR0000062757__AboutThis_22"> Board members review recently published articles each month to determine whether an article should:</p><ul id="CDR0000062757__AboutThis_6"><li class="half_rhythm"><div>be discussed at a meeting,</div></li><li class="half_rhythm"><div>be cited with text, or</div></li><li class="half_rhythm"><div>replace or update an existing article that is already cited.</div></li></ul><p id="CDR0000062757__AboutThis_7">Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary.</p><p id="CDR0000062757__AboutThis_9">Any comments or questions about the summary content should be submitted to Cancer.gov through the NCI website's <a href="http://www.cancer.gov/contact/email-us" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Email Us</a>. Do not contact the individual Board Members with questions or comments about the summaries. Board members will not respond to individual inquiries.</p></div><div id="CDR0000062757__AboutThis_10"><h3>Levels of Evidence</h3><p id="CDR0000062757__AboutThis_11">Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Screening and Prevention Editorial Board uses a <a href="/books/n/pdqcis/CDR0000304747/">formal evidence ranking system</a> in developing its level-of-evidence designations.</p></div><div id="CDR0000062757__AboutThis_12"><h3>Permission to Use This Summary</h3><p id="CDR0000062757__AboutThis_13">PDQ is a registered trademark. Although the content of PDQ documents can be used freely as text, it cannot be identified as an NCI PDQ cancer information summary unless it is presented in its entirety and is regularly updated. However, an author would be permitted to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks succinctly: [include excerpt from the summary].”</p><p id="CDR0000062757__AboutThis_14">The preferred citation for this PDQ summary is:</p><p id="CDR0000062757__AboutThis_15">PDQ® Screening and Prevention Editorial Board. PDQ Stomach (Gastric) Cancer Screening. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: <a href="http://www.cancer.gov/types/stomach/hp/stomach-screening-pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.cancer.gov/types/stomach/hp/stomach-screening-pdq</a>. Accessed <MM/DD/YYYY>. [PMID: 26389174]</p><p id="CDR0000062757__AboutThis_16">Images in this summary are used with permission of the author(s), artist, and/or publisher for use within the PDQ summaries only. Permission to use images outside the context of PDQ information must be obtained from the owner(s) and cannot be granted by the National Cancer Institute. Information about using the illustrations in this summary, along with many other cancer-related images, is available in <a href="http://visualsonline.cancer.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Visuals Online</a>, a collection of over 2,000 scientific images.
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</p></div><div id="CDR0000062757__AboutThis_17"><h3>Disclaimer</h3><p id="CDR0000062757__AboutThis_19">The information in these summaries should not be used as a basis for insurance reimbursement determinations. More information on insurance coverage is available on Cancer.gov on the <a href="http://www.cancer.gov/about-cancer/managing-care" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Managing Cancer Care</a> page.</p></div><div id="CDR0000062757__AboutThis_20"><h3>Contact Us</h3><p id="CDR0000062757__AboutThis_21">More information about contacting us or receiving help with the Cancer.gov website can be found on our <a href="http://www.cancer.gov/contact" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Contact Us for Help</a> page. Questions can also be submitted to Cancer.gov through the website’s <a href="http://www.cancer.gov/contact/email-us" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Email Us</a>.</p></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK65730.2/?report=reader">PubReader</a></li><li><a href="/books/NBK65730.2/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK65730" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK65730" style="display:none" title="Cite this Page"><div class="bk_tt">PDQ Screening and Prevention Editorial Board. Stomach (Gastric) Cancer Screening (PDQ®): Health Professional Version. 2016 Apr 1. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. <span class="bk_cite_avail"></span></div></div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Version History</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter shutter_closed" title="Show/hide content" remembercollapsed="true" pgsec_name="version_history" id="Shutter"></a></div><div class="portlet_content" style="display: none;"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><span class="bk_col_itm"><a href="/books/NBK65730.11/">NBK65730.11</a></span> March 19, 2024</li><li><span class="bk_col_itm"><a href="/books/NBK65730.10/">NBK65730.10</a></span> May 31, 2023</li><li><span class="bk_col_itm"><a href="/books/NBK65730.9/">NBK65730.9</a></span> April 29, 2022</li><li><span class="bk_col_itm"><a href="/books/NBK65730.8/">NBK65730.8</a></span> March 18, 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