nih-gov/www.ncbi.nlm.nih.gov/books/NBK62712/index.html?cmd=HTOff&

487 lines
No EOL
74 KiB
XML

<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
<head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
<!-- AppResources meta begin -->
<meta name="paf-app-resources" content="" />
<script type="text/javascript">var ncbi_startTime = new Date();</script>
<!-- AppResources meta end -->
<!-- TemplateResources meta begin -->
<meta name="paf_template" content="" />
<!-- TemplateResources meta end -->
<!-- Logger begin -->
<meta name="ncbi_db" content="books" /><meta name="ncbi_pdid" content="book-toc" /><meta name="ncbi_acc" content="NBK62712" /><meta name="ncbi_domain" content="nicecg111" /><meta name="ncbi_report" content="record" /><meta name="ncbi_type" content="fulltext" /><meta name="ncbi_objectid" content="" /><meta name="ncbi_pcid" content="/NBK62712/?cmd=HTOff&amp;" /><meta name="ncbi_pagename" content="Nocturnal Enuresis - NCBI Bookshelf" /><meta name="ncbi_bookparttype" content="toc" /><meta name="ncbi_app" content="bookshelf" />
<!-- Logger end -->
<title>Nocturnal Enuresis - NCBI Bookshelf</title>
<!-- AppResources external_resources begin -->
<link rel="stylesheet" href="/core/jig/1.15.2/css/jig.min.css" /><script type="text/javascript" src="/core/jig/1.15.2/js/jig.min.js"></script>
<!-- AppResources external_resources end -->
<!-- Page meta begin -->
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE,NOIMAGEINDEX" /><meta name="author" content="National Clinical Guideline Centre (UK)" /><meta name="citation_title" content="Nocturnal Enuresis" /><meta name="citation_publisher" content="Royal College of Physicians (UK)" /><meta name="citation_date" content="2010" /><meta name="citation_author" content="National Clinical Guideline Centre (UK)" /><meta name="citation_pmid" content="22031959" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK62712/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Nocturnal Enuresis" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="Royal College of Physicians (UK)" /><meta name="DC.Contributor" content="National Clinical Guideline Centre (UK)" /><meta name="DC.Date" content="2010" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK62712/" /><meta name="DC.Language" content="en" /><meta name="description" content="This guideline aims to provide advice on the assessment and management of children and young people with bedwetting. The guidance is applicable to children and young people up to 19 years with the symptom of bedwetting. It has been common practice to define enuresis as abnormal from 5 years and only to consider children for treatment when they are 7 years. While the prevalence of symptoms decreases with age the guideline scope did not specify a younger age limit in order to consider whether there were useful interventions that might be of benefit to children previously excluded from advice and services." /><meta name="og:title" content="Nocturnal Enuresis" /><meta name="og:type" content="book" /><meta name="og:description" content="This guideline aims to provide advice on the assessment and management of children and young people with bedwetting. The guidance is applicable to children and young people up to 19 years with the symptom of bedwetting. It has been common practice to define enuresis as abnormal from 5 years and only to consider children for treatment when they are 7 years. While the prevalence of symptoms decreases with age the guideline scope did not specify a younger age limit in order to consider whether there were useful interventions that might be of benefit to children previously excluded from advice and services." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK62712/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nicecg111-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/nicecg111/toc/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK62712/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="nicecollect" />
<!-- Page meta end -->
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8B55A67D693C7100000000010300D9.m_13" />
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3985586/3808861/4121862/3974050/3917732/251717/4216701/14534/45193/4113719/3849091/3984811/3751656/4033350/3840896/3577051/3852958/4008682/4207974/4206132/4062871/12930/3964959/3854974/36029/4128070/9685/3549676/3609192/3609193/3609213/3395586.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3411343/3882866.css" media="print" /></head>
<body class="book-toc">
<div class="grid">
<div class="col twelve_col nomargin shadow">
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
<div class="sysmessages">
<noscript>
<p class="nojs">
<strong>Warning:</strong>
The NCBI web site requires JavaScript to function.
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
</p>
</noscript>
</div>
<!--/.sysmessage-->
<div class="wrap">
<div class="page">
<div class="top">
<div id="universal_header">
<section class="usa-banner">
<div class="usa-accordion">
<header class="usa-banner-header">
<div class="usa-grid usa-banner-inner">
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
<p>An official website of the United States government</p>
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
<span class="usa-banner-button-text">Here's how you know</span>
</button>
</div>
</header>
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
<div class="usa-banner-guidance-gov usa-width-one-half">
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
<div class="usa-media_block-body">
<p>
<strong>The .gov means it's official.</strong>
<br />
Federal government websites often end in .gov or .mil. Before
sharing sensitive information, make sure you're on a federal
government site.
</p>
</div>
</div>
<div class="usa-banner-guidance-ssl usa-width-one-half">
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
<div class="usa-media_block-body">
<p>
<strong>The site is secure.</strong>
<br />
The <strong>https://</strong> ensures that you are connecting to the
official website and that any information you provide is encrypted
and transmitted securely.
</p>
</div>
</div>
</div>
</div>
</section>
<div class="usa-overlay"></div>
<header class="ncbi-header" role="banner" data-section="Header">
<div class="usa-grid">
<div class="usa-width-one-whole">
<div class="ncbi-header__logo">
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
</a>
</div>
<div class="ncbi-header__account">
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
<span class="fa fa-user" aria-hidden="true">
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
<g style="fill: #fff">
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
</g>
</svg>
</span>
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
<span class="sr-only">Show account info</span>
</button>
</div>
<div class="ncbi-popup-anchor">
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
<div class="ncbi-popup-head">
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
<span class="fa fa-times">
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
</svg>
</span>
<span class="usa-sr-only">Close</span></button>
<h4>Account</h4>
</div>
<div class="account-user-info">
Logged in as:<br />
<b><span class="username" id="uname_long">username</span></b>
</div>
<div class="account-links">
<ul class="usa-unstyled-list">
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
</ul>
</div>
</div>
</div>
</div>
</div>
</header>
<div role="navigation" aria-label="access keys">
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
</div>
<section data-section="Alerts">
<div class="ncbi-alerts-placeholder"></div>
</section>
</div>
<div class="header">
<div class="res_logo"><h1 class="res_name"><a href="/books/" title="Bookshelf home">Bookshelf</a></h1><h2 class="res_tagline"></h2></div>
<div class="search"><form method="get" action="/books/"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="books" selected="selected" data-ac_dict="bookshelf-search">Books</option><option value="nuccore">Nucleotide</option><option value="taxonomy">Taxonomy</option><option value="omim" class="last">OMIM</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books" data-ac_dict="bookshelf-search">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Books. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'bookshelf-search',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'no',afs:'no'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div></form><ul class="searchlinks inline_list"><li>
<a href="/books/browse/">Browse Titles</a>
</li><li>
<a href="/books/advanced/">Advanced</a>
</li><li class="help">
<a href="/books/NBK3833/">Help</a>
</li><li class="disclaimer">
<a target="_blank" data-ga-category="literature_resources" data-ga-action="link_click" data-ga-label="disclaimer_link" href="https://www.ncbi.nlm.nih.gov/books/about/disclaimer/">Disclaimer</a>
</li></ul></div>
</div>
<!--<component id="Page" label="headcontent"/>-->
</div>
<div class="content">
<!-- site messages -->
<!-- Custom content 1 -->
<div class="col1">
</div>
<div class="container">
<div id="maincontent" class="content eight_col col">
<!-- Custom content in the left column above book nav -->
<div class="col2">
</div>
<!-- Book content -->
<!-- Custom content between navigation and content -->
<div class="col3">
</div>
<div class="source">
<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">&lt; Prev</span><a class="active page_link next" href="/books/n/nicecg111/nicecg111.fm.s1/" title="Next page in this title">Next &gt;</a></div></div></div>
<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="http://www.rcplondon.ac.uk/Pages/index.aspx" title="Royal College of Physicians (UK)" class="img_link icnblk_img" ref="pagearea=logo&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nicecg111-lrg.png" alt="Cover of Nocturnal Enuresis" /></a><div class="icnblk_cntnt"><h1 id="_NBK62712_"><span itemprop="name">Nocturnal Enuresis</span></h1><div class="subtitle">The Management of Bedwetting in Children and Young People</div><p><i>NICE Clinical Guidelines, No. 111</i></p><p class="contrib-group"><span itemprop="author">National Clinical Guideline Centre (UK)</span>.</p><div class="half_rhythm">London: <a href="http://www.rcplondon.ac.uk/Pages/index.aspx" ref="pagearea=meta&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher"><span itemprop="publisher">Royal College of Physicians (UK)</span></a>; <span itemprop="datePublished">2010</span>.</div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK62712" data-jigconfig="modal:true">Copyright and
Permissions</a></span></li></ul></div><div id="_ncbi_dlg_cpyrght_NBK62712" style="display:none" title="Copyright and&#10; Permissions"><div><div>Copyright &#x000a9; 2010, National Clinical Guideline Centre.</div><div class="half_rhythm"><div>Apart from any fair dealing for the purposes of research or private study, criticism or review, as permitted under the Copyright, Designs and Patents Act, 1988, no part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.</div><div>The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.</div><div>The rights of the National Clinical Guideline Centre to be identified as Author of this work have been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988.</div></div></div></div><div class="bk_noprnt"><form method="get" action="/books/n/nicecg111/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div itemprop="description"><h2>Excerpt</h2><p>This guideline aims to provide advice on the assessment and management of children and young people with bedwetting. The guidance is applicable to children and young people up to 19 years with the symptom of bedwetting. It has been common practice to define <a class="def" href="/books/n/nicecg111/ch2/def-item/glossary.gl1-d59/">enuresis</a> as abnormal from 5 years and only to consider children for treatment when they are 7 years. While the prevalence of symptoms decreases with age the guideline scope did not specify a younger age limit in order to consider whether there were useful interventions that might be of benefit to children previously excluded from advice and services.</p></div><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK62712_nicecg111_fm_s1" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK62712_nicecg111_fm_s1"><a href="/books/n/nicecg111/nicecg111.fm.s1/" class="toc-item">Patient-Centered Care</a></li><li class="half_rhythm" id="toc_itm_NBK62712_nicecg111_fm_s2"><a href="/books/n/nicecg111/nicecg111.fm.s2/" class="toc-item">Key priorities for implementation</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1"><a href="/books/n/nicecg111/ch1/" class="toc-item">1. Guidance</a><ul id="toc_lst_NBK62712_ch1_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s1"><a href="/books/n/nicecg111/ch1/#ch1.s1" class="toc-item">1.1 Principles of care</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s2"><a href="/books/n/nicecg111/ch1/#ch1.s2" class="toc-item">1.2 Information for the child or young person and family</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s3"><a href="/books/n/nicecg111/ch1/#ch1.s3" class="toc-item">1.3 Assessment and investigation</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s4"><a href="/books/n/nicecg111/ch1/#ch1.s4" class="toc-item">1.4 Planning management</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s5"><a href="/books/n/nicecg111/ch1/#ch1.s5" class="toc-item">1.5 Advice on fluid intake, diet and toileting patterns</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s6"><a href="/books/n/nicecg111/ch1/#ch1.s6" class="toc-item">1.6 Lifting and waking</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s7"><a href="/books/n/nicecg111/ch1/#ch1.s7" class="toc-item">1.7 Reward systems</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s8"><a href="/books/n/nicecg111/ch1/#ch1.s8" class="toc-item">1.8 Initial treatment &#x02013; alarms</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s10"><a href="/books/n/nicecg111/ch1/#ch1.s10" class="toc-item">1.9 Lack of response to alarm treatment</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s11"><a href="/books/n/nicecg111/ch1/#ch1.s11" class="toc-item">1.10 Initial treatment &#x02013; desmopressin</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s12"><a href="/books/n/nicecg111/ch1/#ch1.s12" class="toc-item">1.11 Children and young people experiencing recurrence of bedwetting</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s13"><a href="/books/n/nicecg111/ch1/#ch1.s13" class="toc-item">1.12 Lack of response to initial treatment options</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s14"><a href="/books/n/nicecg111/ch1/#ch1.s14" class="toc-item">1.13 Anticholinergics</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s15"><a href="/books/n/nicecg111/ch1/#ch1.s15" class="toc-item">1.14 Tricyclics</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s16"><a href="/books/n/nicecg111/ch1/#ch1.s16" class="toc-item">1.15 Training programmes for the management of bedwetting</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch1_s17"><a href="/books/n/nicecg111/ch1/#ch1.s17" class="toc-item">1.16 Children under 5 years with bedwetting</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2"><a href="/books/n/nicecg111/ch2/" class="toc-item">2. Introduction</a><ul id="toc_lst_NBK62712_ch2_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s1"><a href="/books/n/nicecg111/ch2/#ch2.s1" class="toc-item">2.1 Nocturnal Enuresis and Bedwetting</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s6"><a href="/books/n/nicecg111/ch2/#ch2.s6" class="toc-item">2.2 Approach of this Guideline</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s7"><a href="/books/n/nicecg111/ch2/#ch2.s7" class="toc-item">2.3 Remit</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s8"><a href="/books/n/nicecg111/ch2/#ch2.s8" class="toc-item">2.4 What is a guideline?</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s9"><a href="/books/n/nicecg111/ch2/#ch2.s9" class="toc-item">2.5 What the guideline covers</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s12"><a href="/books/n/nicecg111/ch2/#ch2.s12" class="toc-item">2.6 What the guideline does not cover</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s14"><a href="/books/n/nicecg111/ch2/#ch2.s14" class="toc-item">2.7 Guideline Limitations</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s15"><a href="/books/n/nicecg111/ch2/#ch2.s15" class="toc-item">2.8 Who developed this guideline?</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s23"><a href="/books/n/nicecg111/ch2/#ch2.s23" class="toc-item">2.9 Research recommendations</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s39"><a href="/books/n/nicecg111/ch2/#ch2.s39" class="toc-item">2.10 Acknowledgements</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch2_s40"><a href="/books/n/nicecg111/ch2/#ch2.s40" class="toc-item">2.11 Glossary</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3"><a href="/books/n/nicecg111/ch3/" class="toc-item">3. Methods</a><ul id="toc_lst_NBK62712_ch3_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s1"><a href="/books/n/nicecg111/ch3/#ch3.s1" class="toc-item">3.1 Guideline methodology</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s2"><a href="/books/n/nicecg111/ch3/#ch3.s2" class="toc-item">3.2 Process of guideline development</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s3"><a href="/books/n/nicecg111/ch3/#ch3.s3" class="toc-item">3.3 Developing the clinical questions</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s4"><a href="/books/n/nicecg111/ch3/#ch3.s4" class="toc-item">3.4 Outcomes</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s7"><a href="/books/n/nicecg111/ch3/#ch3.s7" class="toc-item">3.5 Choice of subgroups</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s8"><a href="/books/n/nicecg111/ch3/#ch3.s8" class="toc-item">3.6 Literature search strategy</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s11"><a href="/books/n/nicecg111/ch3/#ch3.s11" class="toc-item">3.7 Assessing quality of evidence</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s14"><a href="/books/n/nicecg111/ch3/#ch3.s14" class="toc-item">3.8 GRADE (Grading of Recommendations, Assessment, Development and Evaluation)</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s21"><a href="/books/n/nicecg111/ch3/#ch3.s21" class="toc-item">3.9 Evidence reviewing process</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s33"><a href="/books/n/nicecg111/ch3/#ch3.s33" class="toc-item">3.10 Health Economics methods</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s36"><a href="/books/n/nicecg111/ch3/#ch3.s36" class="toc-item">3.11 Development of the recommendations</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s37"><a href="/books/n/nicecg111/ch3/#ch3.s37" class="toc-item">3.12 Areas without evidence and consensus methodology</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s38"><a href="/books/n/nicecg111/ch3/#ch3.s38" class="toc-item">3.13 Update</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s39"><a href="/books/n/nicecg111/ch3/#ch3.s39" class="toc-item">3.14 Consultation</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s40"><a href="/books/n/nicecg111/ch3/#ch3.s40" class="toc-item">3.15 Related NICE Guidance</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s41"><a href="/books/n/nicecg111/ch3/#ch3.s41" class="toc-item">3.16 Disclaimer</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch3_s42"><a href="/books/n/nicecg111/ch3/#ch3.s42" class="toc-item">3.17 Funding</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch4"><a href="/books/n/nicecg111/ch4/" class="toc-item">4. Impact of bedwettingon children and young people and their families</a><ul id="toc_lst_NBK62712_ch4_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch4_s1"><a href="/books/n/nicecg111/ch4/#ch4.s1" class="toc-item">4.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch4_s2"><a href="/books/n/nicecg111/ch4/#ch4.s2" class="toc-item">4.2 What is the family impact of children and young people aged under 19 who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch5"><a href="/books/n/nicecg111/ch5/" class="toc-item">5. Patient Choice in children and young people with bedwetting</a><ul id="toc_lst_NBK62712_ch5_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch5_s1"><a href="/books/n/nicecg111/ch5/#ch5.s1" class="toc-item">5.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch5_s2"><a href="/books/n/nicecg111/ch5/#ch5.s2" class="toc-item">5.2 In children and young people with bedwetting, how does patient or parent/carer choice over treatment intervention influence treatment outcomes?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch6"><a href="/books/n/nicecg111/ch6/" class="toc-item">6. Assessment for children with Bedwetting</a><ul id="toc_lst_NBK62712_ch6_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch6_s1"><a href="/books/n/nicecg111/ch6/#ch6.s1" class="toc-item">6.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch6_s2"><a href="/books/n/nicecg111/ch6/#ch6.s2" class="toc-item">6.2 What are the core elements of initial clinical history and examination, and what are the core laboratory urine/blood tests in the evaluation of children and young people under 19 years old who have bedwetting?</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch6_s29"><a href="/books/n/nicecg111/ch6/#ch6.s29" class="toc-item">6.3 What is the incremental benefit and cost effectiveness of radiological examination, in the evaluation of children and young people under 19 years old who have bedwetting?</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch6_s49"><a href="/books/n/nicecg111/ch6/#ch6.s49" class="toc-item">6.4 What are the core elements of bladder diaries and other assessment tools, in the evaluation of children and young people under 19 years old who have bedwetting?</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch6_s60"><a href="/books/n/nicecg111/ch6/#ch6.s60" class="toc-item">6.5 How should a psychological assessment be conducted, in the evaluation of children and young people under 19 years old who have bedwetting?</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch6_s70"><a href="/books/n/nicecg111/ch6/#ch6.s70" class="toc-item">6.6 What is the clinical and cost effectiveness of additional investigation and treatment in children who have not responded to an adequate trial of both desmopressin and or alarms?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch7"><a href="/books/n/nicecg111/ch7/" class="toc-item">7. Fluid and diet restriction for the management of bedwetting</a><ul id="toc_lst_NBK62712_ch7_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch7_s1"><a href="/books/n/nicecg111/ch7/#ch7.s1" class="toc-item">7.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch7_s2"><a href="/books/n/nicecg111/ch7/#ch7.s2" class="toc-item">7.2 What is the clinical and cost effectiveness of fluid and/or diet restriction for children and young people under 19 years who have bedwetting?</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch7_s3"><a href="/books/n/nicecg111/ch7/#ch7.s3" class="toc-item">7.3 Fluid restriction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch7_s17"><a href="/books/n/nicecg111/ch7/#ch7.s17" class="toc-item">7.4 Dietary restriction</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch8"><a href="/books/n/nicecg111/ch8/" class="toc-item">8. Lifting and waking in the management of bedwetting</a><ul id="toc_lst_NBK62712_ch8_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch8_s1"><a href="/books/n/nicecg111/ch8/#ch8.s1" class="toc-item">8.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch8_s2"><a href="/books/n/nicecg111/ch8/#ch8.s2" class="toc-item">8.2 What is the clinical and cost effectiveness of lifting and waking for children and young people under 19 years who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch9"><a href="/books/n/nicecg111/ch9/" class="toc-item">9. Bladder training and retention control training for the management of bedwetting</a><ul id="toc_lst_NBK62712_ch9_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch9_s1"><a href="/books/n/nicecg111/ch9/#ch9.s1" class="toc-item">9.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch9_s2"><a href="/books/n/nicecg111/ch9/#ch9.s2" class="toc-item">9.2 What is the clinical and cost effectiveness of bladder training and retention control training for children and young people under 19 years who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch10"><a href="/books/n/nicecg111/ch10/" class="toc-item">10. Star Charts in the management of bedwetting</a><ul id="toc_lst_NBK62712_ch10_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch10_s1"><a href="/books/n/nicecg111/ch10/#ch10.s1" class="toc-item">10.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch10_s2"><a href="/books/n/nicecg111/ch10/#ch10.s2" class="toc-item">10.2 What is the clinical and cost effectiveness of the use of star charts for children and young people under 19 years who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch11"><a href="/books/n/nicecg111/ch11/" class="toc-item">11. Dry bed training for the management of bedwetting</a><ul id="toc_lst_NBK62712_ch11_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch11_s1"><a href="/books/n/nicecg111/ch11/#ch11.s1" class="toc-item">11.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch11_s2"><a href="/books/n/nicecg111/ch11/#ch11.s2" class="toc-item">11.2 What is the clinical and cost effectiveness of dry bed training for children and young people under 19 years who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch12"><a href="/books/n/nicecg111/ch12/" class="toc-item">12. Enuresis Alarms in the management of bedwetting</a><ul id="toc_lst_NBK62712_ch12_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch12_s1"><a href="/books/n/nicecg111/ch12/#ch12.s1" class="toc-item">12.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch12_s2"><a href="/books/n/nicecg111/ch12/#ch12.s2" class="toc-item">12.2 What is the clinical and cost effectiveness of enuresis alarms for children and young people under 19 years old who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch13"><a href="/books/n/nicecg111/ch13/" class="toc-item">13. Desmopressin and the management of bedwetting</a><ul id="toc_lst_NBK62712_ch13_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch13_s1"><a href="/books/n/nicecg111/ch13/#ch13.s1" class="toc-item">13.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch13_s2"><a href="/books/n/nicecg111/ch13/#ch13.s2" class="toc-item">13.2 What is the clinical and cost effectiveness of desmopressin for children and young people under 19 years who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch14"><a href="/books/n/nicecg111/ch14/" class="toc-item">14. Anticholinergic medication for the management of Nocturnal Enuresis</a><ul id="toc_lst_NBK62712_ch14_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch14_s1"><a href="/books/n/nicecg111/ch14/#ch14.s1" class="toc-item">14.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch14_s2"><a href="/books/n/nicecg111/ch14/#ch14.s2" class="toc-item">14.2 What is the clinical and cost effectiveness of anticholinergic medication for children and young people under 19 years who have nocturnal enuresis?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch15"><a href="/books/n/nicecg111/ch15/" class="toc-item">15. Tricyclic medication and the management of bedwetting</a><ul id="toc_lst_NBK62712_ch15_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch15_s1"><a href="/books/n/nicecg111/ch15/#ch15.s1" class="toc-item">15.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch15_s2"><a href="/books/n/nicecg111/ch15/#ch15.s2" class="toc-item">15.2 What is the clinical and cost effectiveness of tricyclic medication for children and young people under 19 years who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch16"><a href="/books/n/nicecg111/ch16/" class="toc-item">16. Dose escalation in the management of bedwetting</a><ul id="toc_lst_NBK62712_ch16_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch16_s1"><a href="/books/n/nicecg111/ch16/#ch16.s1" class="toc-item">16.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch16_s2"><a href="/books/n/nicecg111/ch16/#ch16.s2" class="toc-item">16.2 What is the clinical and cost effectiveness of dose escalation for children and young people under 19 years who have bedwetting</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch17"><a href="/books/n/nicecg111/ch17/" class="toc-item">17. Treatment for children who do not respond to initial treatment with desmopressin and / or enuresis alarms for the management of bedwetting</a><ul id="toc_lst_NBK62712_ch17_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch17_s1"><a href="/books/n/nicecg111/ch17/#ch17.s1" class="toc-item">17.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch17_s2"><a href="/books/n/nicecg111/ch17/#ch17.s2" class="toc-item">17.2 What is the clinical and cost effectiveness of additional treatment in children who have not responded to an adequate trial of desmopressin and / or enuresis alarms</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch18"><a href="/books/n/nicecg111/ch18/" class="toc-item">18. Treatment for children who have recurrence of bedwetting after previous successful treatment for bedwetting</a><ul id="toc_lst_NBK62712_ch18_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch18_s1"><a href="/books/n/nicecg111/ch18/#ch18.s1" class="toc-item">18.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch18_s2"><a href="/books/n/nicecg111/ch18/#ch18.s2" class="toc-item">18.2 What is the clinical and cost effectiveness of treating relapses in children after previously successful treatment for bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch19"><a href="/books/n/nicecg111/ch19/" class="toc-item">19. Psychological treatments for the management of bedwetting</a><ul id="toc_lst_NBK62712_ch19_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch19_s1"><a href="/books/n/nicecg111/ch19/#ch19.s1" class="toc-item">19.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch19_s2"><a href="/books/n/nicecg111/ch19/#ch19.s2" class="toc-item">19.2 What is the clinical and cost effectiveness of psychological interventions for children and young people under 19 years who have bedwetting</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch20"><a href="/books/n/nicecg111/ch20/" class="toc-item">20. Information and Educational interventions for the management of bedwetting</a><ul id="toc_lst_NBK62712_ch20_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch20_s1"><a href="/books/n/nicecg111/ch20/#ch20.s1" class="toc-item">20.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch20_s2"><a href="/books/n/nicecg111/ch20/#ch20.s2" class="toc-item">20.2 What is the clinical and cost effectiveness of information and educational interventions for children and young people under 19 years who have bedwetting</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch21"><a href="/books/n/nicecg111/ch21/" class="toc-item">21. Alternative treatments for the management of bedwetting</a><ul id="toc_lst_NBK62712_ch21_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch21_s1"><a href="/books/n/nicecg111/ch21/#ch21.s1" class="toc-item">21.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch21_s2"><a href="/books/n/nicecg111/ch21/#ch21.s2" class="toc-item">21.2 What is the clinical and cost effectiveness of alternative treatments for children and young people under 19 years who have bedwetting</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch22"><a href="/books/n/nicecg111/ch22/" class="toc-item">22. Under 5 year olds and management of bedwetting</a><ul id="toc_lst_NBK62712_ch22_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch22_s1"><a href="/books/n/nicecg111/ch22/#ch22.s1" class="toc-item">22.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch22_s2"><a href="/books/n/nicecg111/ch22/#ch22.s2" class="toc-item">22.2 In children under 5 years old with nocturnal enuresis, are there any preventative, prediction or treatment options which should be considered?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch23"><a href="/books/n/nicecg111/ch23/" class="toc-item">23. Support and follow-up for children with Bedwetting</a><ul id="toc_lst_NBK62712_ch23_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch23_s1"><a href="/books/n/nicecg111/ch23/#ch23.s1" class="toc-item">23.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch23_s2"><a href="/books/n/nicecg111/ch23/#ch23.s2" class="toc-item">23.2 What is the clinical and cost effectiveness of support and follow up care for children and young people under 19 years old who have bedwetting? What is the clinical and cost effectiveness of support and follow up care for the parents and carers of children and young people under 19 years old who have bedwetting?</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_ch24"><a href="/books/n/nicecg111/ch24/" class="toc-item">24. Network Meta-Analysis</a><ul id="toc_lst_NBK62712_ch24_s1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK62712_ch24_s1"><a href="/books/n/nicecg111/ch24/#ch24.s1" class="toc-item">24.1 Introduction</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch24_s2"><a href="/books/n/nicecg111/ch24/#ch24.s2" class="toc-item">24.2 Comparability of interventions</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch24_s3"><a href="/books/n/nicecg111/ch24/#ch24.s3" class="toc-item">24.3 Methods</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch24_s7"><a href="/books/n/nicecg111/ch24/#ch24.s7" class="toc-item">24.4 Results</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch24_s8"><a href="/books/n/nicecg111/ch24/#ch24.s8" class="toc-item">24.5 Discussion</a></li><li class="half_rhythm" id="toc_itm_NBK62712_ch24_rl1"><a href="/books/n/nicecg111/ch24/#ch24.rl1" class="toc-item">24.6 Reference List</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK62712_appendixes_app1"><a href="/books/n/nicecg111/appendixes.app1/" class="toc-item">Appendix A Nocturnal Enuresis Final Scope</a></li><li class="half_rhythm" id="toc_itm_NBK62712_appendixes_app2"><a href="/books/n/nicecg111/appendixes.app2/" class="toc-item">Appendix B Key Clinical Questions and Search Strategies</a></li><li class="half_rhythm" id="toc_itm_NBK62712_appendixes_app3"><a href="/books/n/nicecg111/appendixes.app3/" class="toc-item">Appendix C Clinical Evidence Extractions</a></li><li class="half_rhythm" id="toc_itm_NBK62712_appendixes_app4"><a href="/books/n/nicecg111/appendixes.app4/" class="toc-item">Appendix D Health Economic Extractions</a></li><li class="half_rhythm" id="toc_itm_NBK62712_appendixes_app5"><a href="/books/n/nicecg111/appendixes.app5/" class="toc-item">Appendix E Guideline Development Group Declarations of Interest</a></li><li class="half_rhythm" id="toc_itm_NBK62712_appendixes_app6"><a href="/books/n/nicecg111/appendixes.app6/" class="toc-item">Appendix F Network meta-analysis of interventions for the treatment of bedwetting</a></li><li class="half_rhythm" id="toc_itm_NBK62712_appendixes_app7"><a href="/books/n/nicecg111/appendixes.app7/" class="toc-item">Appendix G Cost-effectiveness analysis of intervention sequences for the treatment of bedwetting</a></li><li class="half_rhythm" id="toc_itm_NBK62712_appendixes_app8"><a href="/books/n/nicecg111/appendixes.app8/" class="toc-item">Appendix H GRADE profile tables</a></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div><h4 class="inline">Suggested citation:</h4><p>National Clinical Guideline Centre, (2010). Nocturnal enuresis: The management of bedwetting in children and young people. London: National Clinical Guideline Centre. Available from: [<a href="http://www.nice.org.uk" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">www.nice.org.uk</a>]</p></div></div></div>
<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © 2010, National Clinical Guideline Centre.<p class="small">Apart from any fair dealing for the purposes of research or private study, criticism or review, as permitted under the Copyright, Designs and Patents Act, 1988, no part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.</p><p class="small">The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.</p><p class="small">The rights of the National Clinical Guideline Centre to be identified as Author of this work have been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988.</p></div><div class="small"><span class="label">Bookshelf ID: NBK62712</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/22031959" title="PubMed record of this title" ref="pagearea=meta&amp;targetsite=entrez&amp;targetcat=link&amp;targettype=pubmed">22031959</a></span></div><div style="margin-top:2em" class="bk_noprnt"><div class="pagination bk_noprnt"><span class="inactive page_link prev">&lt; Prev</span><a class="active page_link next" href="/books/n/nicecg111/nicecg111.fm.s1/" title="Next page in this title">Next &gt;</a></div></div></div></div>
</div>
<!-- Custom content below content -->
<div class="col4">
</div>
<!-- Book content -->
<!-- Custom contetnt below bottom nav -->
<div class="col5">
</div>
</div>
<div id="rightcolumn" class="four_col col last">
<!-- Custom content above discovery portlets -->
<div class="col6">
<div id="ncbi_share_book"><a href="#" class="ncbi_share" data-ncbi_share_config="popup:false,shorten:true" ref="id=NBK62712&amp;db=books">Share</a></div>
</div>
<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK62712/?report=reader">PubReader</a></li><li><a href="/books/NBK62712/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK62712" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK62712" style="display:none" title="Cite this Page"><div class="bk_tt">National Clinical Guideline Centre (UK). Nocturnal Enuresis: The Management of Bedwetting in Children and Young People. London: Royal College of Physicians (UK); 2010. (NICE Clinical Guidelines, No. 111.)<span class="bk_cite_avail"></span></div></div></li><li><a href="/books/n/nicecg111/pdf/">PDF version of this title</a> (5.3M)</li><li><a href="#" class="toggle-glossary-link" title="Enable/disable links to the glossary">Disable Glossary Links</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Other titles in this collection</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/n/nicecollect/">National Institute for Health and Clinical Excellence: Guidance
</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related NICE guidance and evidence</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/n/nicecg111surv/">2018 surveillance of bedwetting in under 19s (NICE guideline CG111)</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=nlmcatalog&amp;DbFrom=books&amp;Cmd=Link&amp;LinkName=books_nlmcatalog&amp;IdsFromResult=2637334" ref="log$=recordlinks">NLM Catalog</a><div class="brieflinkpop offscreen_noflow">Related NLM Catalog Entries</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/25189037" ref="ordinalpos=1&amp;linkpos=1&amp;log$=relatedarticles&amp;logdbfrom=pubmed">[General recommendations for the initial management of primary monosymptomatic nocturnal enuresis in children].</a><span class="source">[Harefuah. 2014]</span><div class="brieflinkpop offscreen_noflow">[General recommendations for the initial management of primary monosymptomatic nocturnal enuresis in children].<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Neheman A, Cohen AH, Chertin B, Metz Y, Ish-Shalom N, Meir DB, Ben-Chaim J, Don Z, Avishalom P. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Harefuah. 2014 Jul; 153(7):428-31. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/21214139" ref="ordinalpos=1&amp;linkpos=2&amp;log$=relatedarticles&amp;logdbfrom=pubmed">Nocturnal enuresis: assessing and treating children and young people.</a><span class="source">[Community Pract. 2010]</span><div class="brieflinkpop offscreen_noflow">Nocturnal enuresis: assessing and treating children and young people.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Wootton J, Norfolk S. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Community Pract. 2010 Dec; 83(12):37-9. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/16042739" ref="ordinalpos=1&amp;linkpos=3&amp;log$=relatedarticles&amp;logdbfrom=pubmed">Nocturnal enuresis at 7.5 years old: prevalence and analysis of clinical signs.</a><span class="source">[BJU Int. 2005]</span><div class="brieflinkpop offscreen_noflow">Nocturnal enuresis at 7.5 years old: prevalence and analysis of clinical signs.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Butler RJ, Golding J, Northstone K, ALSPAC Study Team. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">BJU Int. 2005 Aug; 96(3):404-10. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/11917829" ref="ordinalpos=1&amp;linkpos=4&amp;log$=relatedreviews&amp;logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Management of bedwetting.</a><span class="source">[Aust Fam Physician. 2002]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Management of bedwetting.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Moulden A. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Aust Fam Physician. 2002 Feb; 31(2):161-3. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/11487066" ref="ordinalpos=1&amp;linkpos=5&amp;log$=relatedreviews&amp;logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Impact of nocturnal enuresis on children and young people.</a><span class="source">[Scand J Urol Nephrol. 2001]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Impact of nocturnal enuresis on children and young people.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Butler RJ. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Scand J Urol Nephrol. 2001 Jun; 35(3):169-76. </em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&amp;cmd=link&amp;linkname=pubmed_pubmed_reviews&amp;uid=22031959" ref="ordinalpos=1&amp;log$=relatedreviews_seeall&amp;logdbfrom=pubmed">See reviews...</a><a class="seemore" href="/sites/entrez?db=pubmed&amp;cmd=link&amp;linkname=pubmed_pubmed&amp;uid=22031959" ref="ordinalpos=1&amp;log$=relatedarticles_seeall&amp;logdbfrom=pubmed">See all...</a></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Recent Activity</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="Shutter"></a></div><div class="portlet_content"><div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" id="HTDisplay" class=""><div class="action"><a href="javascript:historyDisplayState('ClearHT')">Clear</a><a href="javascript:historyDisplayState('HTOff')" class="HTOn">Turn Off</a><a href="javascript:historyDisplayState('HTOn')" class="HTOff">Turn On</a></div><ul id="activity"><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d6a91bcde49f3df7d64584">Nocturnal Enuresis</a><div class="ralinkpop offscreen_noflow">Nocturnal Enuresis<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d6a91acde49f3df7d641bc">Figure 3, NMA 2: Intervention vs no treatment for full response for children wit...</a><div class="ralinkpop offscreen_noflow">Figure 3, NMA 2: Intervention vs no treatment for full response for children with bedwetting with possible daytime symptoms - Nocturnal Enuresis<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d6a91984f3725e59253e67">Figure 2, NMA 1: Intervention vs no treatment for full response for children wit...</a><div class="ralinkpop offscreen_noflow">Figure 2, NMA 1: Intervention vs no treatment for full response for children with bedwetting only - Nocturnal Enuresis<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d6a91967c23b31e0abeae8">Figure 1, Schematic of Natural History Model for Bedwetting - Nocturnal Enuresis</a><div class="ralinkpop offscreen_noflow">Figure 1, Schematic of Natural History Model for Bedwetting - Nocturnal Enuresis<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d6a918cde49f3df7d63b88">Figure 3, Basecase deterministic results on the cost-effectiveness plane - Noctu...</a><div class="ralinkpop offscreen_noflow">Figure 3, Basecase deterministic results on the cost-effectiveness plane - Nocturnal Enuresis<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li></ul><p class="HTOn">Your browsing activity is empty.</p><p class="HTOff">Activity recording is turned off.</p><p id="turnOn" class="HTOff"><a href="javascript:historyDisplayState('HTOn')">Turn recording back on</a></p><a class="seemore" href="/sites/myncbi/recentactivity">See more...</a></div></div></div>
<!-- Custom content below discovery portlets -->
<div class="col7">
</div>
</div>
</div>
<!-- Custom content after all -->
<div class="col8">
</div>
<div class="col9">
</div>
<script type="text/javascript" src="/corehtml/pmc/js/jquery.scrollTo-1.4.2.js"></script>
<script type="text/javascript">
(function($){
$('.skiplink').each(function(i, item){
var href = $($(item).attr('href'));
href.attr('tabindex', '-1').addClass('skiptarget'); // ensure the target can receive focus
$(item).on('click', function(event){
event.preventDefault();
$.scrollTo(href, 0, {
onAfter: function(){
href.focus();
}
});
});
});
})(jQuery);
</script>
</div>
<div class="bottom">
<script type="text/javascript">
var PBooksSearchTermData = {
highlighter: "bold",
dateTime: "03/16/2025 05:16:39",
terms: [
'degeneration', 'disease', 'hepatolenticular', 'hepatolenticular degeneration', 'hepatolenticular degeneration', 'practice guideline', 'wilson', 'wilson disease'
]
};
</script>
<div id="NCBIFooter_dynamic">
<!--<component id="Breadcrumbs" label="breadcrumbs"/>
<component id="Breadcrumbs" label="helpdesk"/>-->
</div>
<div class="footer" id="footer">
<section class="icon-section">
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
<div class="grid-container container">
<div class="icon-section_container">
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<defs>
<style>
.cls-11 {
fill: #737373;
}
</style>
</defs>
<title>Twitter</title>
<path class="cls-11" d="M250.11,105.48c-7,3.14-13,3.25-19.27.14,8.12-4.86,8.49-8.27,11.43-17.46a78.8,78.8,0,0,1-25,9.55,39.35,39.35,0,0,0-67,35.85,111.6,111.6,0,0,1-81-41.08A39.37,39.37,0,0,0,81.47,145a39.08,39.08,0,0,1-17.8-4.92c0,.17,0,.33,0,.5a39.32,39.32,0,0,0,31.53,38.54,39.26,39.26,0,0,1-17.75.68,39.37,39.37,0,0,0,36.72,27.3A79.07,79.07,0,0,1,56,223.34,111.31,111.31,0,0,0,116.22,241c72.3,0,111.83-59.9,111.83-111.84,0-1.71,0-3.4-.1-5.09C235.62,118.54,244.84,113.37,250.11,105.48Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<title>Facebook</title>
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<title>LinkedIn</title>
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<defs>
<style>
.cls-11,
.cls-12 {
fill: #737373;
}
.cls-11 {
fill-rule: evenodd;
}
</style>
</defs>
<title>GitHub</title>
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
</path>
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
</path>
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
</path>
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
</path>
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
</path>
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
</path>
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
</svg></a>
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
<defs><style>.cls-1{fill:#737373;}</style></defs>
<title>NCBI Insights Blog</title>
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
</svg>
</a>
</div>
</div>
</section>
<section class="container-fluid bg-primary">
<div class="container pt-5">
<div class="row mt-3">
<div class="col-lg-3 col-12">
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
<ul class="list-inline social_media">
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" viewBox="0 0 249 249" style="enable-background:new 0 0 249 249;" xml:space="preserve">
<style type="text/css">
.st20 {
fill: #FFFFFF;
}
.st30 {
fill: none;
stroke: #FFFFFF;
stroke-width: 8;
stroke-miterlimit: 10;
}
</style>
<title>Twitter</title>
<g>
<g>
<g>
<path class="st20" d="M192.9,88.1c-5,2.2-9.2,2.3-13.6,0.1c5.7-3.4,6-5.8,8.1-12.3c-5.4,3.2-11.4,5.5-17.6,6.7 c-10.5-11.2-28.1-11.7-39.2-1.2c-7.2,6.8-10.2,16.9-8,26.5c-22.3-1.1-43.1-11.7-57.2-29C58,91.6,61.8,107.9,74,116 c-4.4-0.1-8.7-1.3-12.6-3.4c0,0.1,0,0.2,0,0.4c0,13.2,9.3,24.6,22.3,27.2c-4.1,1.1-8.4,1.3-12.5,0.5c3.6,11.3,14,19,25.9,19.3 c-11.6,9.1-26.4,13.2-41.1,11.5c12.7,8.1,27.4,12.5,42.5,12.5c51,0,78.9-42.2,78.9-78.9c0-1.2,0-2.4-0.1-3.6 C182.7,97.4,189.2,93.7,192.9,88.1z"></path>
</g>
</g>
<circle class="st30" cx="124.4" cy="128.8" r="108.2"></circle>
</g>
</svg></a></li>
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" viewBox="0 0 249 249" style="enable-background:new 0 0 249 249;" xml:space="preserve">
<style type="text/css">
.st10 {
fill: #FFFFFF;
}
.st110 {
fill: none;
stroke: #FFFFFF;
stroke-width: 8;
stroke-miterlimit: 10;
}
</style>
<title>Facebook</title>
<g>
<g>
<path class="st10" d="M159,99.1h-24V88.4c0-5,3.3-6.2,5.7-6.2h16.8V60l-24.4-0.1c-22.1,0-26.2,16.5-26.2,27.1v12.1H90v22.5h16.9 v67.5H135v-67.5h21.7L159,99.1z"></path>
</g>
</g>
<circle class="st110" cx="123.6" cy="123.2" r="108.2"></circle>
</svg>
</a></li>
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" viewBox="0 0 249 249" style="enable-background:new 0 0 249 249;" xml:space="preserve">
<title>Youtube</title>
<style type="text/css">
.st4 {
fill: none;
stroke: #FFFFFF;
stroke-width: 8;
stroke-miterlimit: 10;
}
.st5 {
fill: #FFFFFF;
}
</style>
<circle class="st4" cx="124.2" cy="123.4" r="108.2"></circle>
<g transform="translate(0,-952.36218)">
<path class="st5" d="M88.4,1037.4c-10.4,0-18.7,8.3-18.7,18.7v40.1c0,10.4,8.3,18.7,18.7,18.7h72.1c10.4,0,18.7-8.3,18.7-18.7 v-40.1c0-10.4-8.3-18.7-18.7-18.7H88.4z M115.2,1058.8l29.4,17.4l-29.4,17.4V1058.8z"></path>
</g>
</svg></a></li>
</ul>
</div>
<div class="col-lg-3 col-12">
<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
</div>
</div>
<div class="row">
<div class="col-lg-12 centered-lg">
<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
</li>
<li>
<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
</li>
<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
</li>
</ul>
</nav>
</div>
</div>
</div>
</section>
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
</div>
</div>
</div>
<!--/.page-->
</div>
<!--/.wrap-->
</div><!-- /.twelve_col -->
</div>
<!-- /.grid -->
<span class="PAFAppResources"></span>
<!-- BESelector tab -->
<noscript><img alt="statistics" src="/stat?jsdisabled=true&amp;ncbi_db=books&amp;ncbi_pdid=book-toc&amp;ncbi_acc=NBK62712&amp;ncbi_domain=nicecg111&amp;ncbi_report=record&amp;ncbi_type=fulltext&amp;ncbi_objectid=&amp;ncbi_pcid=/NBK62712/?cmd=HTOff&amp;&amp;ncbi_pagename=Nocturnal Enuresis - NCBI Bookshelf&amp;ncbi_bookparttype=toc&amp;ncbi_app=bookshelf" /></noscript>
<!-- usually for JS scripts at page bottom -->
<!--<component id="PageFixtures" label="styles"></component>-->
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal104 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3879255/4121861/3501987/4008961/3893018/3821238/4062932/4209313/4212053/4076480/3921943/3400083/3426610.js" snapshot="books"></script></body>
</html>