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<meta name="og:description" content="Recent evidence has suggested that MRI screening increases the sensitivity of breast cancer screening at the expense of specificity. This additional sensitivity has the potential to identify cases sooner which ought to lead to more promising prognoses. Furthermore, a hastening of a correct identification can prevent disutility associated with false negatives prior to their eventual diagnosis. Similarly, evidence has suggested that the sensitivity of the mammography options is partially compromised in younger groups, due to breast tissue density issues. The benefit of MRI screening has to be contrasted between different groups of women, and then compared with the cost implications that MRI screening has, both in the screening programme (such as the cost of those incorrectly brought back for further investigation) and in the wider National Health Service.">
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placeholder="search this page" id="jr-fip-term" autocorrect="off" autocomplete="off" /><a id="jr-fip-mg" class="wsprkl btn" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><p class="vip-notice"><strong><a href="/books/n/nicecg164guid/?report=reader">See 2019 update</a></strong></p><p class="vip-notice retraction"><strong>This publication is provided for historical reference only and the information may be out of date.</strong></p><div class="main-content lit-style"><div class="fm-sec bkr_bottom_sep"><div class="bkr_thumb"><a href="http://www.rcgp.org.uk/default.aspx?page=399" title="Royal College of General Practitioners (UK)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nicecg41-lrg.png" alt="Cover of Familial Breast Cancer" /></a></div><div class="bkr_bib"><h1 id="_NBK62028_"><span itemprop="name">Familial Breast Cancer</span></h1><div class="subtitle">The Classification and Care of Women at Risk of Familial Breast Cancer in Primary, Secondary and Tertiary Care: Update</div><p><i>NICE Clinical Guidelines, No. 41</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Collaborating Centre for Primary Care (UK)</span>.</p><div class="half_rhythm">London: <a href="http://www.rcgp.org.uk/default.aspx?page=399" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">Royal College of General Practitioners (UK)</span></a>; <span itemprop="datePublished">2006 Jul</span>.</div><div><a href="/books/about/copyright/">Copyright</a> © 2006, National Collaborating Centre for Primary Care.</div><a class="btn wsprkl bkr_rd" href="/books/n/nicecg41/ch1/?report=reader">Read</a></div><div class="bkr_clear"></div></div><div class="bkr_bottom_sep bkr_bottom_margin body-content whole_rhythm"><div itemprop="description"><h2>Excerpt</h2><p>Recent evidence has suggested that MRI screening increases the sensitivity of breast cancer screening at the expense of specificity. This additional sensitivity has the potential to identify cases sooner which ought to lead to more promising prognoses. Furthermore, a hastening of a correct identification can prevent disutility associated with false negatives prior to their eventual diagnosis. Similarly, evidence has suggested that the sensitivity of the mammography options is partially compromised in younger groups, due to breast tissue density issues. The benefit of MRI screening has to be contrasted between different groups of women, and then compared with the cost implications that MRI screening has, both in the screening programme (such as the cost of those incorrectly brought back for further investigation) and in the wider National Health Service.</p><p>The primary question that this investigation is looking to answer is whether MRI screening can be recommended on clinical and cost-effectiveness grounds in particular populations of women.</p></div></div></div><div class="fm-sec"><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © 2006, National Collaborating Centre for Primary Care.</div><div class="small"><span class="label">Bookshelf ID: NBK62028</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/23285504" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">23285504</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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