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<meta name="citation_title" content="Advanced Breast Cancer">
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<meta name="citation_date" content="2009/02">
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<meta name="citation_author" content="National Collaborating Centre for Cancer (UK)">
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<meta name="DC.Title" content="Advanced Breast Cancer">
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<meta name="og:description" content="Breast cancer is the most common cancer for women in England and Wales, with about 37,000 new cases diagnosed and 11,000 deaths recorded in England and Wales each year. In men breast cancer is rare, with about 270 cases diagnosed, and 70 deaths in England and Wales each year. Of these new cases in women and men, around 10% are diagnosed in the advanced stages, when the tumour has spread significantly within the breast or to other organs of the body. In addition, there is a significant number of women who have been previously treated with curative intent who subsequently develop either a local recurrence or metastases. Over recent years there have been important developments in the investigation and management of these patients including new chemotherapy, and biological and hormonal agents. There is some evidence of practice variation across the country and of patchy availability of certain treatments and procedures. A clinical guideline will help to address these issues and offer guidance on best practice.">
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<meta name="warning" content="Since original publication this guideline has been partially updated by NICE: In August 2017, we reviewed the evidence for assessing oestrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) status on disease recurrence and changed the recommendations in section 1.1. In July 2014, we reviewed the evidence for exercise for people with lymphoedema and added 2 new recommendations. Parts of this guideline were updated by a standing committee in 2017. One recommendation was deleted (crossed out) and 2 recommendations (marked in grey) in section 2.2 (page 9) were replaced with 1 new recommendation. This can be found in the addendum to this guideline, Advanced breast cancer 81.2.">
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In July 2014, we reviewed the evidence for exercise for people with lymphoedema and added 2 new recommendations. Parts of this guideline were updated by a standing committee in 2017. One recommendation was deleted (crossed out) and 2 recommendations (marked in grey) in section 2.2 (page 9) were replaced with 1 new recommendation. This can be found in the addendum to this guideline, Advanced breast cancer 81.2.</strong></p><div class="main-content lit-style"><div class="fm-sec bkr_bottom_sep"><div class="bkr_thumb"><a href="http://www.wales.nhs.uk/sites3/home.cfm?OrgID=432" title="National Collaborating Centre for Cancer (UK)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nicecg81-lrg.png" alt="Cover of Advanced Breast Cancer" /></a></div><div class="bkr_bib"><h1 id="_NBK61870_"><span itemprop="name">Advanced Breast Cancer</span></h1><div class="subtitle">Diagnosis and Treatment</div><p><i>NICE Clinical Guidelines, No. 81</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Collaborating Centre for Cancer (UK)</span>.</p><div class="half_rhythm">Cardiff (UK): <a href="http://www.wales.nhs.uk/sites3/home.cfm?OrgID=432" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Collaborating Centre for Cancer (UK)</span></a>; <span itemprop="datePublished">2009 Feb</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-0-9558265-3-5</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © 2009, National Collaborating Centre for Cancer.</div><a class="btn wsprkl bkr_rd" href="/books/n/nicecg81/nicecg81.s1/?report=reader">Read</a></div><div class="bkr_clear"></div></div><div class="bkr_bottom_sep bkr_bottom_margin body-content whole_rhythm"><div itemprop="description"><p>Breast cancer is the most common cancer for women in England and Wales, with about 37,000 new cases diagnosed and 11,000 deaths recorded in England and Wales each year. In men breast cancer is rare, with about 270 cases diagnosed, and 70 deaths in England and Wales each year. Of these new cases in women and men, around 10% are diagnosed in the advanced stages, when the tumour has spread significantly within the breast or to other organs of the body. In addition, there is a significant number of women who have been previously treated with curative intent who subsequently develop either a local recurrence or metastases. Over recent years there have been important developments in the investigation and management of these patients including new chemotherapy, and biological and hormonal agents. There is some evidence of practice variation across the country and of patchy availability of certain treatments and procedures. A clinical guideline will help to address these issues and offer guidance on best practice.</p></div></div></div><div class="fm-sec"><div><p>This guideline updates and replaces NICE technology appraisal guidance 62 (capecitabine), 54 (vinorelbine) and 30 (taxanes).</p></div><div><p>While every effort has been made to ensure the accuracy of the information contained within this publication, the publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check current indications and accuracy by consulting other pharmaceutical literature and following the guidelines laid down by the manufacturers of specific products and the relevant authorities in the country in which they are practising.</p></div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © 2009, National Collaborating Centre for Cancer.<p class="small">No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licenses issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.</p><p class="small">The use of registered names, trademarks etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.</p></div><div class="small"><span class="label">Bookshelf ID: NBK61870</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/21901868" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">21901868</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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