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</svg> Books</a></div><div class="jr-rhead f1 flexh"><div class="head"></div><div class="body"><div class="t">Clopidogrel (Plavix®)</div><div class="j">Mother To Baby | Fact Sheets [Internet]</div></div><div class="tail"></div></div><div id="jr-tb2"><a id="jr-bkhelp-sw" class="btn wsprkl hidden" title="Help with NLM PubReader">?</a><a id="jr-help-sw" class="btn wsprkl hidden" title="Settings and typography in NLM PubReader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" preserveAspectRatio="none"><path d="M462,283.742v-55.485l-29.981-10.662c-11.431-4.065-20.628-12.794-25.274-24.001 c-0.002-0.004-0.004-0.009-0.006-0.013c-4.659-11.235-4.333-23.918,0.889-34.903l13.653-28.724l-39.234-39.234l-28.72,13.652 c-10.979,5.219-23.68,5.546-34.908,0.889c-0.005-0.002-0.01-0.003-0.014-0.005c-11.215-4.65-19.933-13.834-24-25.273L283.741,50 h-55.484l-10.662,29.981c-4.065,11.431-12.794,20.627-24.001,25.274c-0.005,0.002-0.009,0.004-0.014,0.005 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placeholder="search this page" id="jr-fip-term" autocorrect="off" autocomplete="off" /><a id="jr-fip-mg" class="wsprkl btn" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK605067_"><span class="title" itemprop="name">Clopidogrel (Plavix®)</span></h1><p class="fm-aai"><a href="#_NBK605067_pubdet_">Publication Details</a></p></div></div><div class="body-content whole_rhythm" itemprop="text"><div id="clopidogrel-sp.clopidogrel-sp_s_001"><div class="h2"></div><p>Esta hoja trata sobre la exposición a clopidogrel en el embarazo y durante la lactancia. Esta información se basa en la literatura publicada disponible. No debe usarse como un sustituto de la atención médica o los consejos de su proveedor de atención de salud.</p><p>
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<b>
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<i>¿Qué es el clopidogrel?</i>
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</p><blockquote><p>El clopidogrel es un medicamento antiplaquetario que ayuda a prevenir los coágulos sanguíneos. Se ha utilizado para ayudar a prevenir ataques cardíacos y derrames cerebrales. Una marca comercial para clopidogrel es Plavix®.</p><p>A veces, cuando las personas se enteran de que están embarazadas, piensan en cambiar la forma de tomar sus medicamentos o dejar de tomarlos por completo. Sin embargo, es importante hablar con sus proveedores de atención de salud antes de realizar cambios en la forma en que toma su medicamento. Sus proveedores de atención de salud pueden hablar con usted sobre los beneficios de tratar su afección y los riesgos de enfermedad no tratada durante el embarazo.</p></blockquote><p>
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<b>
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<i>Tomo clopidogrel. ¿Puede hacer que me resulte más difícil quedar embarazada?</i>
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</b>
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</p><blockquote><p>No se han realizado estudios en humanos para ver si el clopidogrel puede dificultar el embarazo. En estudios con animales, el clopidogrel no afectó la fertilidad (capacidad de quedar embarazada).</p></blockquote><p>
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<b>
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<i>¿Tomar clopidogrel aumenta la probabilidad de aborto espontáneo?</i>
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</b>
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</p><blockquote><p>El aborto espontáneo es común y puede ocurrir en cualquier embarazo por muchas razones diferentes. No se han realizado estudios en humanos para ver si el clopidogrel aumenta la posibilidad de aborto espontáneo. En estudios con animales, no se informó de un aumento en los abortos espontáneos.</p></blockquote><p>
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<b>
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<i>¿Tomar clopidogrel aumenta la probabilidad de defectos de nacimiento?</i>
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</b>
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</p><blockquote><p>Cada embarazo comienza con un 3-5% de probabilidad de tener un defecto de nacimiento. Esto se conoce como riesgo de fondo. La información sobre el uso de clopidogrel durante el embarazo es limitada. En estudios con animales, el clopidogrel no aumentó la probabilidad de defectos de nacimiento. En 17 informes de casos de personas que tomaron clopidogrel durante el embarazo, no se informaron defectos de nacimiento en 16 de los bebés. Se reportó un defecto cardíaco en 1 bebé. Un solo informe de caso no es información suficiente para vincular una exposición con un defecto de nacimiento. Además, en todos estos informes, también se tomaron otros medicamentos durante el embarazo. Esto hace que sea difícil saber si el clopidogrel, la combinación de medicamentos u otros factores están relacionados con el defecto cardíaco reportado.</p></blockquote><p>
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<b>
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<i>¿Tomar clopidogrel durante el embarazo aumenta la probabilidad de otros problemas relacionados con el embarazo?</i>
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</b>
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</p><blockquote><p>No se han realizado estudios para ver el clopidrogel aumenta la probabilidad de problemas relacionados con el embarazo, como parto prematuro (parto antes de la semana 37) o bajo peso al nacer (que pesa menos de 5 libras, 8 onzas [2500 gramos] al nacer).</p><p>Tomar clopidogrel durante el trabajo de parto o en el momento del parto puede aumentar la probabilidad de sangrado y hemorragia (pérdida excesiva de sangre) en la persona que da a luz. También existe una mayor probabilidad de hematoma espinal (cuando la sangre se acumula en la columna vertebral) cuando las personas que toman clopidogrel reciben una epidural (inyección de medicamento en el espacio alrededor de los nervios espinales para aliviar el dolor (analgesia) o entumecer un área del cuerpo). La etiqueta del producto y las sociedades médicas profesionales, incluida la Sociedad Estadounidense de Anestesia Regional y Medicina del Dolor y la Academia Estadounidense de Medicina del Dolor, han recomendado que cualquier persona que tome clopidogrel deje de tomarlo de 5 a 7 días antes del trabajo de parto, el parto o la epidural.</p></blockquote><p>
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<b>
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<i>¿Tomar clopidogrel durante el embarazo afecta el comportamiento o aprendizaje futuro para el niño?</i>
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</b>
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</p><blockquote><p>No se han realizado estudios para ver si el clopidrogel puede causar problemas de comportamiento o aprendizaje en el niño.</p></blockquote><p>La lactancia mientras tomar <i><b><i>clopidogrel</i></b></i>:</p><blockquote><p>No hay estudios publicados sobre el uso de clopidogrel durante la lactancia. No se han notificado efectos secundarios en un pequeño número de lactantes expuestos al clopidogrel a través de la leche materna. Si sospecha que el bebé tiene algún síntoma (como moretones o sangrado), comuníquese con el proveedor de atención de salud del niño.</p><p>Existe una preocupación teórica (no probada) de que, si un bebé está expuesto al clopidogrel a través de la leche materna, es posible que las plaquetas del bebé no funcionen correctamente. Esto no se ha reportado en los informes sobre lactantes expuestos al clopidogrel a través de la leche materna.</p></blockquote><p>
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<b>
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<i>Si un hombre toma clopidogrel, ¿podría afectar la fertilidad o aumentar la probabilidad de defectos de nacimiento?</i>
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</b>
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</p><blockquote><p>No se han realizado estudios para ver si el clopidrogel podría afectar la fertilidad masculina (capacidad de embarazar a la pareja) o aumentar la probabilidad de defectos de nacimiento por encima del riesgo de fondo. En general, es poco probable que las exposiciones que tienen los padres o donantes de esperma aumenten los riesgos de un embarazo. Para más información, consulte la hoja informativa de MotherToBaby acerca de Exposiciones Paternas en <a href="https://mothertobaby.org/es/hojas-informativas/exposiciones-paternas/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://mothertobaby.org/es/hojas-informativas/exposiciones-paternas/</a>.</p></blockquote></div><div id="R001"><h2 id="_R001_">Referencias Seleccionadas:</h2><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="c001">Al-Aqeedi
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RF, et al. 2008. Drug-eluting stent implantation for acute myocardial infarction during pregnancy with use of glycoprotein IIb/IIa inhibitor, aspirin, and clopidogren.
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J Invasive Cardiol
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T, et al. 2009. Acute myocardial infarction associated with pregnancy successfully treated with percutaneous coronary intervention.
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P, et al. 2001. Case report: successful pregnancy and delivery after myocardial infarction and essential thrombocytopenia treated with clopidogrel.
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31:29-35. [<a href="https://pubmed.ncbi.nlm.nih.gov/17306138" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17306138</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="c012">Martin
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M, et al. 2003. Acute myocardial infarction during pregnancy. Treatment with clopidogrel. Med Clin (Bar);
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GR, et al. 2011. Clopidogrel use throughout pregnancy in a patient with a drug-eluting coronary stent.
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Obstet Gynecol. (2 Pt 2):432-433. [<a href="https://pubmed.ncbi.nlm.nih.gov/21768844" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21768844</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="c014">Nallamothu
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BK, et al. 2005. Clinical problem solving. Double jeopardy.
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N Engl J Med; 353:75-80. [<a href="https://pubmed.ncbi.nlm.nih.gov/16000358" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16000358</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="c015">Narouze
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Reg Anesthes <em>Pain Med.</em>
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2018;43:225–262. [<a href="https://pubmed.ncbi.nlm.nih.gov/29278603" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29278603</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="c016">O’Shanahan
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N, et al. 2006. Acute coronary syndrome without ST elevation during pregnancy.
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Med Intensiva;
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30:180-182. [<a href="https://pubmed.ncbi.nlm.nih.gov/16750081" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16750081</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="c017">Reilly
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290(3):591-594. [<a href="https://pubmed.ncbi.nlm.nih.gov/24798936" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24798936</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="c018">Santiago-Diaz
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62:1197-1198. [<a href="https://pubmed.ncbi.nlm.nih.gov/19793530" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19793530</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="c019">Sanofi-aventis
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P, et al. 2004. Spontaneous dissection of the left main coronary artery.
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20:815-818. [<a href="https://pubmed.ncbi.nlm.nih.gov/15229764" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15229764</span></a>]</div></p></li></ul></div></div></div><div class="fm-sec"><h2 id="_NBK605067_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Published online: April 2024.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> de OTIS, abril 2024.<p class="small">This work is available under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported license (<a href="https://creativecommons.org/licenses/by-nc-nd/3.0/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=uri">CC BY-NC-ND 3.0</a>)</p></div></div><h3>Publisher</h3><p><a href="https://mothertobaby.org/fact-sheets/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">Organization of Teratology Information Specialists (OTIS)</a>, Brentwood (TN)</p><h3>NLM Citation</h3><p>Mother To Baby | Fact Sheets [Internet]. Brentwood (TN): Organization of Teratology Information Specialists (OTIS); 1994-. Clopidogrel (Plavix®) 2024 Apr.<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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