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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Delamanid" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/06/15" /><meta name="citation_pmid" content="38913818" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK604413/" /><meta name="citation_keywords" content="Delamanid" /><meta name="citation_keywords" content="OPC-67683" /><meta name="citation_keywords" content="Deltyba" /><meta name="citation_keywords" content="OPC 67683" /><meta name="citation_keywords" content="8OOT6M1PC7" /><meta name="citation_keywords" content="OPC67683" /><meta name="citation_keywords" content="MMV688262" /><meta name="citation_keywords" content="UNII-8OOT6M1PC7" /><meta name="citation_keywords" content="SCHEMBL57791" /><meta name="citation_keywords" content="CHEMBL218650" /><meta name="citation_keywords" content="GTPL12876" /><meta name="citation_keywords" content="DTXSID60218326" /><meta name="citation_keywords" content="C25H25F3" /><meta name="citation_keywords" content="N4O6" /><meta name="citation_keywords" content="CHEBI:134742" /><meta name="citation_keywords" content="BCP07838" /><meta name="citation_keywords" content="EX-A2414" /><meta name="citation_keywords" content="BDBM50592580" /><meta name="citation_keywords" content="MFCD18251539" /><meta name="citation_keywords" content="NSC794689" /><meta name="citation_keywords" content="s5007" /><meta name="citation_keywords" content="AKOS025289781" /><meta name="citation_keywords" content="CCG-269934" /><meta name="citation_keywords" content="CS-5866" /><meta name="citation_keywords" content="DB11637" /><meta name="citation_keywords" content="NSC-794689" /><meta name="citation_keywords" content="SB14863" /><meta name="citation_keywords" content="NCGC00348214-01" /><meta name="citation_keywords" content="AC-35849" /><meta name="citation_keywords" content="AS-56105" /><meta name="citation_keywords" content="HY-10846" /><meta name="citation_keywords" content="NS00072495" /><meta name="citation_keywords" content="D09785" /><meta name="citation_keywords" content="A856044" /><meta name="citation_keywords" content="EN300-20602812" /><meta name="citation_keywords" content="Q15408413" /><meta name="citation_keywords" content="(2R)-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-3H-imidazo[2,1-b][1,3]oxazole" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Delamanid" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/06/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK604413/" /><meta name="description" content="Delamanid is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. No information is available on the clinical use of delamanid during breastfeeding. Preliminary evidence indicates that delamanid and its active metabolite are present in milk at low levels. Delamanid is usually given with several other drugs for resistant tuberculosis, so the clinical importance of these small amounts is unclear." /><meta name="og:title" content="Delamanid" /><meta name="og:type" content="book" /><meta name="og:description" content="Delamanid is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. No information is available on the clinical use of delamanid during breastfeeding. Preliminary evidence indicates that delamanid and its active metabolite are present in milk at low levels. Delamanid is usually given with several other drugs for resistant tuberculosis, so the clinical importance of these small amounts is unclear." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK604413/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/delamanid/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK604413/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK604413_"><span class="title" itemprop="name">Delamanid</span></h1><p class="small">Last Revision: <span itemprop="dateModified">June 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 681492-22-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/390742880" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=390742880" alt="image 390742880 in the ncbi pubchem database" /></a><div id="delamanid.Drug_Levels_and_Effects"><h2 id="_delamanid_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="delamanid.Summary_of_Use_during_Lactatio"><h3>Summary of Use during Lactation</h3><p>Delamanid is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. No information is available on the clinical use of delamanid during breastfeeding. Preliminary evidence indicates that delamanid and its active metabolite are present in milk at low levels. Delamanid is usually given with several other drugs for resistant tuberculosis, so the clinical importance of these small amounts is unclear.</p></div><div id="delamanid.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> The breastmilk of two patients receiving delamanid in unspecified doses had peak delamanid milk levels 4 hours after a dose. One had a peak delamanid milk level of about 200 mcg/L and a level of the active metabolite DM-6705 that was undetectable (<10 mcg/L) at all time points. The second woman had a peak delamanid level of about 700 mcg/L and a peak milk level of the active metabolite DM-6705 of about 40 mcg/L at 4 hours after the dose. Because the serum level of the first patient was also low, it was thought that her adherence to the regimen was poor.[<a class="bk_pop" href="#delamanid.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="delamanid.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="delamanid.Effects_on_Lactation_and_Breas"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="delamanid.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="delamanid.REF.1">Mkhize
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B, Court
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R, Castel
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S, et al.
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Validation and application of an online extraction and liquid chromatography tandem mass spectrometry assay for the analysis of delamanid and its DM-6705 metabolite in human breast milk.
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J Pharm Biomed Anal
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2024;246:116225.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/38761519" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 38761519</span></a>]</div></dd></dl></div></div><div id="delamanid.Substance_Identification"><h2 id="_delamanid_Substance_Identification_">Substance Identification</h2><div id="delamanid.Substance_Name"><h3>Substance Name</h3><p>Delamanid</p></div><div id="delamanid.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>681492-22-8</p></div><div id="delamanid.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-infective Agents</p><p>Antitubercular Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK604413</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38913818" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">38913818</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM1331/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM653/" title="Next page in this title">Next ></a></div></div></div></div>
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