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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Opipramol" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/06/15" /><meta name="citation_pmid" content="38913819" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK604412/" /><meta name="citation_keywords" content="Opipramol" /><meta name="citation_keywords" content="Nisidana" /><meta name="citation_keywords" content="Endison" /><meta name="citation_keywords" content="Insidon" /><meta name="citation_keywords" content="Pramolan" /><meta name="citation_keywords" content="NSC-169867" /><meta name="citation_keywords" content="CHEMBL370753" /><meta name="citation_keywords" content="D23ZXO613C" /><meta name="citation_keywords" content="GR 33040" /><meta name="citation_keywords" content="NCGC00162068" /><meta name="citation_keywords" content="EINECS 206-254-0" /><meta name="citation_keywords" content="BRN 0627076" /><meta name="citation_keywords" content="Oprea1_247234" /><meta name="citation_keywords" content="SCHEMBL49841" /><meta name="citation_keywords" content="DTXSID3023394" /><meta name="citation_keywords" content="CHEBI:94614" /><meta name="citation_keywords" content="GTPL11247" /><meta name="citation_keywords" content="BDBM50170636" /><meta name="citation_keywords" content="MFCD00865455" /><meta name="citation_keywords" content="NSC169867" /><meta name="citation_keywords" content="AKOS003588969" /><meta name="citation_keywords" content="DB12930" /><meta name="citation_keywords" content="SDCCGSBI-0633687.P001" /><meta name="citation_keywords" content="AC-15972" /><meta name="citation_keywords" content="MS-25790" /><meta name="citation_keywords" content="1ST161646" /><meta name="citation_keywords" content="HY-118901CS-0077653" /><meta name="citation_keywords" content="NS00010442" /><meta name="citation_keywords" content="D08297" /><meta name="citation_keywords" content="EN300-18531271" /><meta name="citation_keywords" content="Q416562" /><meta name="citation_keywords" content="J-018476" /><meta name="citation_keywords" content="Z2216903864" /><meta name="citation_keywords" content="2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Opipramol" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/06/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK604412/" /><meta name="description" content="Opipramol is not approved for marketing in the United States, but is available overseas. No information is available on the clinical use of opipramol during breastfeeding. Amounts in breastmilk appear to be low and would not be expected to cause any adverse effects in breastfed infants. However, the analytic technique used in the paper would not meet modern standards." /><meta name="og:title" content="Opipramol" /><meta name="og:type" content="book" /><meta name="og:description" content="Opipramol is not approved for marketing in the United States, but is available overseas. No information is available on the clinical use of opipramol during breastfeeding. Amounts in breastmilk appear to be low and would not be expected to cause any adverse effects in breastfed infants. 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK604412_"><span class="title" itemprop="name">Opipramol</span></h1><p class="small">Last Revision: <span itemprop="dateModified">June 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 315-72-0</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/404298838" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=404298838" alt="image 404298838 in the ncbi pubchem database" /></a><div id="opipramol.Drug_Levels_and_Effects"><h2 id="_opipramol_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="opipramol.Summary_of_Use_during_Lactatio"><h3>Summary of Use during Lactation</h3><p>Opipramol is not approved for marketing in the United States, but is available overseas. No information is available on the clinical use of opipramol during breastfeeding. Amounts in breastmilk appear to be low and would not be expected to cause any adverse effects in breastfed infants. However, the analytic technique used in the paper would not meet modern standards.</p></div><div id="opipramol.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> In an old paper, 10 women were given opipramol 100 mg orally 3 times daily for 2 days. Milk samples were obtained 3 times daily 1.5 hour before the morning dose, 3 hours after the morning dose and 3 hours after the afternoon dose. On day 2, the drug concentrations in milk averaged 40 mcg/L before the morning dose and 65 mcg/L 3 hours after the afternoon dose. The highest milk level found in any participant was 160 mcg/L.[<a class="bk_pop" href="#opipramol.REF.1">1</a>] If a maternal weight of 60 kg and an infant milk intake of 150 mL/kg daily are assumed, and a milk level of 65 mcg/L is used, the relative infant dose of opipramol would be 0.02%. Because of the age of the paper, the accuracy of the analytic method in this paper is questionable.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="opipramol.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="opipramol.Effects_on_Lactation_and_Breas"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="opipramol.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="opipramol.REF.1">von Kobyletzki
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D, Herrman
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B. Opipramol in breast milk?
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Med Welt
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1970;7:267-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/5444226" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 5444226</span></a>]</div></dd></dl></div></div><div id="opipramol.Substance_Identification"><h2 id="_opipramol_Substance_Identification_">Substance Identification</h2><div id="opipramol.Substance_Name"><h3>Substance Name</h3><p>Opipramol</p></div><div id="opipramol.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>315-72-0</p></div><div id="opipramol.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antidepressive Agents, Tricyclic</p><p>Adrenergic Uptake Inhibitors</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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