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stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style"><div class="fm-sec bkr_bottom_sep"><div class="bkr_thumb"><a href="https://www.cancer.gov/nano/research/ncl" title="National Cancer Institute (US)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nciprotocols-lrg.png" alt="Cover of National Cancer Institute’s Nanotechnology Characterization Laboratory Assay Cascade Protocols" /></a></div><div class="bkr_bib"><h1 id="_NBK604273_"><span itemprop="name">National Cancer Institute’s Nanotechnology Characterization Laboratory Assay Cascade Protocols</span></h1><div class="half_rhythm">Bethesda (MD): <a href="https://www.cancer.gov/nano/research/ncl" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Cancer Institute (US)</span></a>; <span itemprop="datePublished">2005 May 1</span>-.</div><div><a href="/books/about/copyright/">Copyright Notice</a></div><a class="btn wsprkl bkr_rd" href="/books/n/nciprotocols/section1/?report=reader">Read</a></div><div class="bkr_clear"></div></div><div class="bkr_bottom_sep bkr_bottom_margin body-content whole_rhythm"><div itemprop="description"><p>The Nanotechnology Characterization Laboratory (NCL) has developed a standardized analytical assay cascade to assist nanotechnology-based drug and device developers with preclinical characterization aimed at defining nanoparticle physicochemical properties, immunological compatibility, general toxicity, and pharmacology. Such characterization is essential for the translation of nanotechnology formulations from the discovery phase into clinical trials. The protocols were developed in close collaboration with the US Food and Drug Administration (US FDA) and the National Institute of Standards and Technology (NIST) and used since 2005 to characterize over a thousand nanoformulations, including but not limited to lipid nanoparticles, liposomes, polymeric micelles, metal colloids and metal oxides, carbon nanotubes, fullerenes, dendrimers, and nucleic acid nanoparticles. The protocols can also be used for characterization of nanomaterials for other types of non-clinical studies.</p></div></div></div><div class="fm-sec"><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div><div class="small"><span class="label">Bookshelf ID: NBK604273</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38896765" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">38896765</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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