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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Dextromethorphan Guaifenesin - StatPearls - NCBI Bookshelf</title>
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<meta name="citation_date" content="2024/05/25">
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<meta name="citation_author" content="Rohan Kapuria">
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<meta name="citation_author" content="Nicole R. Winston">
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</svg> Books</a></div><div class="jr-rhead f1 flexh"><div class="head"></div><div class="body"><div class="t">Dextromethorphan Guaifenesin</div><div class="j">StatPearls [Internet]</div></div><div class="tail"></div></div><div id="jr-tb2"><a id="jr-bkhelp-sw" class="btn wsprkl hidden" title="Help with NLM PubReader">?</a><a id="jr-help-sw" class="btn wsprkl hidden" title="Settings and typography in NLM PubReader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" preserveAspectRatio="none"><path d="M462,283.742v-55.485l-29.981-10.662c-11.431-4.065-20.628-12.794-25.274-24.001 c-0.002-0.004-0.004-0.009-0.006-0.013c-4.659-11.235-4.333-23.918,0.889-34.903l13.653-28.724l-39.234-39.234l-28.72,13.652 c-10.979,5.219-23.68,5.546-34.908,0.889c-0.005-0.002-0.01-0.003-0.014-0.005c-11.215-4.65-19.933-13.834-24-25.273L283.741,50 h-55.484l-10.662,29.981c-4.065,11.431-12.794,20.627-24.001,25.274c-0.005,0.002-0.009,0.004-0.014,0.005 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Guaifenesin</span></h1><p class="contribs">Kapuria R, Winston NR.</p><p class="fm-aai"><a href="#_NBK604212_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="article-159926.s1"><h2 id="_article-159926_s1_">Continuing Education Activity</h2><p>This activity provides a comprehensive overview of dextromethorphan/guaifenesin, a combination medication used to treat productive coughs associated with various respiratory conditions, including acute bronchitis, chronic obstructive pulmonary disease (COPD), and allergies. Designed for interprofessional team members who may administer dextromethorphan/guaifenesin therapy, this activity discusses the indications, actions, contraindications, mechanism of action, adverse event profile, monitoring objectives, and overdose management strategies essential for optimizing patient outcomes in the management of productive coughs and related respiratory ailments.</p><p>
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<b>Objectives:</b>
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<ul><li class="half_rhythm"><div>Assess the mechanism of action and indications for dextromethorphan and guaifenesin.</div></li><li class="half_rhythm"><div>Identify the contraindications for dextromethorphan and guaifenesin and what adverse effects might occur if not administered properly.</div></li><li class="half_rhythm"><div>Develop monitoring goals for patients treated with dextromethorphan and guaifenesin.</div></li><li class="half_rhythm"><div>Collaborate with the interprofessional collaboration in managing a productive cough and treating overdose.</div></li></ul>
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<a href="https://www.statpearls.com/account/trialuserreg/?articleid=159926&utm_source=pubmed&utm_campaign=reviews&utm_content=159926" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Access free multiple choice questions on this topic.</a>
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</p></div><div id="article-159926.s2"><h2 id="_article-159926_s2_">Indications</h2><p>Dextromethorphan/guaifenesin is an over-the-counter combination medication used to treat symptoms of productive cough and chest congestion. Dextromethorphan and guaifenesin were invented separately. Dextromethorphan was invented in 1950 and approved by the FDA in 1958 as a cough suppressant, and guaifenesin was synthesized in 1912 and approved by the FDA in 1952 as an expectorant.</p><p>
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<b>FDA-Approved Indications</b>
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</p><ul><li class="half_rhythm"><div>Productive cough caused by common cold</div></li><li class="half_rhythm"><div>Chest congestion</div></li><li class="half_rhythm"><div>Productive cough caused by allergies</div></li></ul><p>
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<b>Off-Label Uses</b>
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</p><ul><li class="half_rhythm"><div>Acute upper respiratory tract infections</div></li><li class="half_rhythm"><div>Chronic bronchitis <a class="bibr" href="#article-159926.r1" rid="article-159926.r1">[1]</a></div></li><li class="half_rhythm"><div>Productive cough for patients with pneumonia <a class="bibr" href="#article-159926.r2" rid="article-159926.r2">[2]</a></div></li></ul></div><div id="article-159926.s3"><h2 id="_article-159926_s3_">Mechanism of Action</h2><p>Dextromethorphan is an NMDA receptor antagonist that nonselectively inhibits the reuptake of serotonin (5-HT) and catecholamines. Dextromethorphan also agonizes σ-1 receptors in the medullary cough center, suppressing the transmission of cough impulses.<a class="bibr" href="#article-159926.r3" rid="article-159926.r3">[3]</a> </p><p>Guaifenesin is a derivative of xanthine that acts as an expectorant by relaxing bronchial smooth muscle tone. Guaifenesin also irritates the respiratory tract, increasing the volume of fluid in the respiratory tract. Both of these mechanisms contribute to guaifenesin's reduction of mucus viscosity.</p><p>
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<b>Pharmacokinetics</b>
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</p><p>
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<b>Absorption: </b>Dextromethorphan and guaifenesin are well absorbed in the small intestine.</p><p>
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<b>Distribution: </b>Dextromethorphan has a volume of distribution of 5 to 6.7 L/kg. Dextromethorphan is lipophilic, has an ionizable amine group, and is structurally similar to alkaloid opioids, but doesn't interact with the μ receptor. Guaifenesin has a mean volume of distribution of 116 L.</p><p>
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<b>Metabolism: </b>Dextromethorphan is metabolized by the cytochrome P450 enzyme CYP2D6 in the liver into dextrorphan, an active metabolite. Dextromethorphan also undergoes N-demethylation by CYP3A4. Guaifenesin is also metabolized in the liver and is oxidized to β-(2-methoxyphenoxy)-lactic acid and unmethylated to hydroxy-guaifenesin. These 2 metabolites of guaifenesin are inactive.</p><p>
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<b>Excretion:</b> Dextrorphan, β-(2-methoxyphenoxy)-lactic acid, and hydroxy-guaifenesin are excreted by the kidneys in urine. </p></div><div id="article-159926.s4"><h2 id="_article-159926_s4_">Administration</h2><p>
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<b>Available Forms</b>
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</p><p>Dextromethorphan and guaifenesin are administered orally via various formulations, including capsules, granules, syrup, liquid drops, and tablets (timed or extended-release).</p><p>
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<b>Available Strengths</b>
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</p><p>
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<b>Capsule: </b>10 to 200 mg</p><p>
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<b>Granules: </b>(5 to 100 mg)/packet</p><p>
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<b>Liquid</b>
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</p><ul><li class="half_rhythm"><div>(5 to 100 mg)/5 mL</div></li><li class="half_rhythm"><div>(10 to 100 mg)/5 mL</div></li><li class="half_rhythm"><div>(10 to 187 mg)/5 mL</div></li><li class="half_rhythm"><div>(10 to 200 mg)/5 mL</div></li><li class="half_rhythm"><div>(15 to 200 mg)/5 mL</div></li><li class="half_rhythm"><div>(20 to 200 mg)/5 mL</div></li><li class="half_rhythm"><div>(15 to 150 mg)/7.5 mL</div></li><li class="half_rhythm"><div>(10 to 100 mg)/10 mL</div></li></ul><p>
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<b>Tablet</b>
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</p><ul><li class="half_rhythm"><div>15 to 400 mg</div></li><li class="half_rhythm"><div>20 to 400 mg</div></li></ul><p>
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<b>Tablet, Extended-Release</b>
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</p><ul><li class="half_rhythm"><div>30 to 600 mg</div></li><li class="half_rhythm"><div>60 to 1200 mg</div></li></ul><p>
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<b>Adult Dosage</b>
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</p><p>The most common OTC syrup formulation is administered in 10 mL (dextromethorphan 20 mg, guaifenesin 200 mg) increments every 4 hours, which should not exceed 60 mL daily.</p><p>Tablet form dosing is 1 to 2 tablets every 12 hours with a maximum daily ingestion of 4 tablets. There is also a "maximum strength" tablet, administered as a single tablet every 12 hours and a maximum of 2 tablets every 24 hours.</p><p>The granule form of this medication is dosed as 2 to 4 packets every 4 hours with a maximum of 6 doses every 24 hours.</p><p>
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<b>Specific Patient Populations</b>
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</p><p>
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<b>Hepatic impairment:</b> No dose adjustment is advised in the manufacturer label for patients with hepatic impairment. </p><p>
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<b>Renal impairment:</b> No dose adjustment is advised in the manufacturer label for patients with renal impairment.</p><p>
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<b>Pregnancy considerations: </b>These medications should be considered individually based on their pharmacokinetic and pharmacodynamic properties. Guaifenesin at normal OTC doses is acceptable. In contrast, dextromethorphan is metabolized by liver enzymes CYP2D6 and CYP3A. The activity of these enzymes is elevated during pregnancy.<a class="bibr" href="#article-159926.r4" rid="article-159926.r4">[4]</a></p><p>
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<b>
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<b>Breastfeeding considerations:</b>
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</b> Dextromethorphan and dextrorphan are minimally present in breast milk and do not affect the infant.<a class="bibr" href="#article-159926.r5" rid="article-159926.r5">[5]</a> No studies have been conducted regarding the excretion of guaifenesin in breast milk, nor have studies been conducted on the effects of breastfeeding on infants.<a class="bibr" href="#article-159926.r6" rid="article-159926.r6">[6]</a> </p><p>
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<b>Pediatric patients: </b>There is limited data on the safety and efficacy of dextromethorphan and guaifenesin in infants and children. The FDA recommends against using these medications for pediatric patients. </p><p>
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<b>Older patients: </b>No specific dose adjustment is needed for older adults. </p><p>Dextromethorphan and guaifenesin are typically administered to adults in an extended-release suspension, which must be shaken to be absorbed correctly.<a class="bibr" href="#article-159926.r7" rid="article-159926.r7">[7]</a> According to the American Academy of Pediatrics, dextromethorphan and guaifenesin shouldn't be administered to children younger than 4. However, some studies state that dextromethorphan and guaifenesin can be administered to children 2 years old or older in liquid form, but caregivers must accurately measure the liquid amount.<a class="bibr" href="#article-159926.r8" rid="article-159926.r8">[8]</a></p></div><div id="article-159926.s5"><h2 id="_article-159926_s5_">Adverse Effects</h2><p>Dextromethorphan and guaifenesin have multiple adverse reactions that primarily affect the cardiovascular, neurologic, psychiatric, musculoskeletal, renal, and gastrointestinal systems. </p><p>Renal adverse effects include acute renal failure and nephrolithiasis, which are caused by the guaifenesin component of this combination drug. Less common adverse reactions include severe flank pain, hematuria, and oliguria.<a class="bibr" href="#article-159926.r9" rid="article-159926.r9">[9]</a><a class="bibr" href="#article-159926.r10" rid="article-159926.r10">[10]</a> </p><p>Psychiatric adverse effects include a type of psychosis that presents similarly to phencyclidine (PCP) intoxication, which is characterized by paranoid feelings, hallucinations, and delusions.<a class="bibr" href="#article-159926.r11" rid="article-159926.r11">[11]</a> This is partially due to dextrorphan, which noncompetitively antagonizes NMDA receptors. Similarly to PCP and ketamine, dextromethorphan and guaifenesin also cause insomnia; these 4 drugs have similar mechanisms of action, so they cause similar psychosis symptoms. This similarity means dextromethorphan and guaifenesin also pose a high risk for abuse, especially since these medications are available over the counter.<a class="bibr" href="#article-159926.r12" rid="article-159926.r12">[12]</a> </p><p>Dextromethorphan and guaifenesin may cause rhabdomyolysis and subsequent electrolyte abnormalities, including hyperphosphatemia, hyperkalemia, hypomagnesemia, and hypocalcemia.<a class="bibr" href="#article-159926.r13" rid="article-159926.r13">[13]</a></p><p>Gastrointestinal adverse effects include nausea, vomiting, abdominal pain, and diarrhea. Other common side effects include dizziness and drowsiness.</p><p>Dextromethorphan and guaifenesin can affect the cardiovascular system, causing tachycardia and hypertension. These medications may also cause a severe type I hypersensitivity reaction caused by an exaggerated IgE response, which would present with rash, dyspnea, dizziness, and swelling of any part of the oral cavity or face. Dextromethorphan and guaifenesin should generally be avoided in pediatric patients, as there is a lack of evidence for their use in children.<a class="bibr" href="#article-159926.r14" rid="article-159926.r14">[14]</a> Instead, children should be given honey, saline nasal spray, or more fluids to suppress cough; these treatments have minimal or absent risk for adverse effects. </p><p>
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<b>Drug-Drug Interactions:</b>
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</p><ul><li class="half_rhythm"><div>Dextromethorphan and guaifenesin may interact with medications that cause respiratory depression, such as benzodiazepines, opioids, and alcohol. </div></li><li class="half_rhythm"><div>Dextromethorphan and guaifenesin may interact with medications that affect heart rhythm, such as amiodarone, procainamide, and quinidine.</div></li><li class="half_rhythm"><div>Dextromethorphan and guaifenesin may interact with medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs).</div></li><li class="half_rhythm"><div>Dextromethorphan may interact with agents that affect blood sugar levels, such as insulin, sulfonylureas, or metformin.</div></li><li class="half_rhythm"><div>Dextromethorphan and guaifenesin may interact with medications that affect CYP enzyme metabolism, such as rolapitant.</div></li></ul></div><div id="article-159926.s6"><h2 id="_article-159926_s6_">Contraindications</h2><p>Contraindications for dextromethorphan and guaifenesin therapy include concomitant monoamine oxidase inhibitor (MAOI) administration. This combination drug is also contraindicated for patients with phenylketonuria, severe liver or kidney disease, patients younger than 4 years old, patients with known hypersensitivity reactions to dextromethorphan or guaifenesin, and patients with a history of kidney stones. </p><p>MAOIs are used to treat refractory depression by inhibiting MAO-A and MAO-B. MAO-A metabolizes monoamine neurotransmitters such as dopamine, serotonin, and dopamine. Thus, MAOIs can increase serotonin levels in the brain. Dextromethorphan and guaifenesin also increase serotonin levels. Administering these medications simultaneously increases the risk for serotonin syndrome, a life-threatening drug reaction characterized by neuromuscular hyperactivity, autonomic hyperstimulation, and agitation.<a class="bibr" href="#article-159926.r15" rid="article-159926.r15">[15]</a> To avoid serotonin syndrome, dextromethorphan and guaifenesin should not be taken within 14 days of MAOI use or any other drug that increases serotonergic neurotransmission.</p><p>Dextromethorphan and guaifenesin are contraindicated for patients with phenylketonuria. These patients have deficient levels of phenylalanine hydroxylase, an enzyme that converts phenylalanine to tyrosine. Some formulations of dextromethorphan and guaifenesin contain phenylalanine and thus can cause neurological conditions, including seizures, intellectual disability, and tremors.<a class="bibr" href="#article-159926.r16" rid="article-159926.r16">[16]</a></p><p>Dextromethorphan and guaifenesin can cause neonatal gasping syndrome due to trace amounts of benzyl alcohol found in some formulations. Benzyl alcohol causes neonatal gasping syndrome in premature infants and neonates by inducing respiratory distress and central nervous system (CNS) depression. Benzyl alcohol accumulation also causes elevated lactate and reduced bicarbonate levels, resulting in anion gap metabolic acidosis.<a class="bibr" href="#article-159926.r17" rid="article-159926.r17">[17]</a></p><p>Dextromethorphan and guaifenesin are contraindicated for patients with a history of kidney stones, as guaifenesin increases the risk of kidney stones, albeit minimally.<a class="bibr" href="#article-159926.r10" rid="article-159926.r10">[10]</a> The mechanism of this adverse effect involves supersaturation and crystallization of urine. Kidney stone occurrence after administration of this drug combination has only been described in case reports, but this is enough reason to avoid the use of this medication for patients already at high risk for nephrolithiasis.</p><p>Dextromethorphan and guaifenesin are contraindicated for patients younger than 4 years old, as this drug combination may cause death in this age group. Overdose is possible, and children in this age group must not be allowed access to these medications. The Centers for Disease Control and Prevention (CDC) released a policy statement stating that cough suppressants such as dextromethorphan and guaifenesin have no proven efficacy in treating acute cough in this demographic and should be avoided due to the chance of adverse effects.<a class="bibr" href="#article-159926.r18" rid="article-159926.r18">[18]</a></p></div><div id="article-159926.s7"><h2 id="_article-159926_s7_">Monitoring</h2><p>Dextromethorphan and guaifenesin use should be monitored carefully in patients with "poor metabolizer" CYP2D6 enzyme levels and patients who are sedated. This combination medication has a large median toxic dose (TD50) to median effective dose (ED50) ratio (or therapeutic index) in these patients. Dextromethorphan and guaifenesin are typically well tolerated if the contraindications listed above are observed.</p><p>Close monitoring is necessary if dextromethorphan and guaifenesin are taken with oral rolapitant. This drug increases the exposure of substrates metabolized by CYP2D6, such as dextromethorphan and guaifenesin. One study found that a single tablet of rolapitant increased the overall dextromethorphan exposure by 3 times compared to the original dose. Patients who take this drug combination and have "poor metabolizing" CYP2D6 activity must be monitored, as genetics or concomitant drug usage affects this enzyme.<a class="bibr" href="#article-159926.r19" rid="article-159926.r19">[19]</a> Guaifenesin can falsely elevate vanillylmandelic acid levels.<a class="bibr" href="#article-159926.r20" rid="article-159926.r20">[20]</a></p></div><div id="article-159926.s8"><h2 id="_article-159926_s8_">Toxicity</h2><p>Dextromethorphan and guaifenesin have abuse potential. Persons who abuse it or take an increased amount are at risk for overdose.<a class="bibr" href="#article-159926.r3" rid="article-159926.r3">[3]</a></p><p>
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<b>Signs and Symptoms of Overdose</b>
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</p><p>Dextromethorphan and guaifenesin toxicity occurs in different stages, which users refer to as "plateaus." The first "plateau" occurs at 1.5 mg/kg, a dosage causing mild stimulation. The second "plateau" occurs at 2.5 to 7.5 mg/kg; users may experience mild to moderate euphoria and hallucinations. At the third "plateau" of 7.5 to 15 mg/kg, the patient may experience dissociation that some have described as an "out-of-body" state. Finally, at the fourth "plateau," patients experience complete dissociation and become nonresponsive. </p><p>Other signs and symptoms associated with overdose of dextromethorphan and guaifenesin include:</p><ul><li class="half_rhythm"><div>Dyspnea</div></li><li class="half_rhythm"><div>Blurred vision</div></li><li class="half_rhythm"><div>Seizures</div></li><li class="half_rhythm"><div>Vomiting</div></li><li class="half_rhythm"><div>Drowsiness</div></li><li class="half_rhythm"><div>Dizziness</div></li><li class="half_rhythm"><div>Tachycardia</div></li><li class="half_rhythm"><div>Hyperthermia</div></li><li class="half_rhythm"><div>Anxiety</div></li><li class="half_rhythm"><div>Altered mental status</div></li></ul><p>
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<b>Management of Overdose</b>
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</p><p>There is no specific antidote for an overdose of this combination medication, and management is symptomatic. Activated charcoal may absorb dextromethorphan and guaifenesin in the small intestine and stomach, preventing their enterohepatic and vascular circulation and absorption and reducing toxic effects.</p><p>
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<b>Recommendations</b>
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</p><p>If the patient has difficulty breathing, supplemental oxygen and assisted ventilation may be given. Management is typically supportive while monitoring vital signs and electrolyte levels. Naloxone can reverse coma and respiratory depression in patients who have overdosed but should not be used as a substitute for supportive care.<a class="bibr" href="#article-159926.r21" rid="article-159926.r21">[21]</a></p></div><div id="article-159926.s9"><h2 id="_article-159926_s9_">Enhancing Healthcare Team Outcomes </h2><p>Patients with a productive cough as a symptom of the common cold, allergies, or chest congestion can use dextromethorphan and guaifenesin to relieve their symptoms acutely. Physicians, advanced practitioners, nurses, pharmacists, and other healthcare professionals must know this combination's pharmacodynamic properties, adverse effects, and monitoring goals. Because dextromethorphan and guaifenesin are commonly purchased over the counter, practitioners and pharmacists should also educate patients on recommended dosages based on mucus production and cough severity. </p><p>Ethical considerations include ensuring patient autonomy and education on the recommended doses to prevent overdose. Interprofessional collaboration is essential to ensure proper dosing for patients taking this medication combination. Prevention or management of overdose occurs when the paramedics reach the scene of an overdose, the triage nurse suspects an overdose upon patient arrival, or the physician informs the patient of proper dosing of this medication. This coordination between healthcare professionals enhances patient education to prevent overdose, treats symptoms and ensures patient safety.</p></div><div id="article-159926.s10"><h2 id="_article-159926_s10_">Review Questions</h2><ul><li class="half_rhythm"><div>
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<a href="https://www.statpearls.com/articlelibrary/commentarticle/159926/?utm_source=pubmed&utm_campaign=comments&utm_content=159926" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Comment on this article.</a>
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</div></li></ul></div><div id="article-159926.s11"><h2 id="_article-159926_s11_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="article-159926.r1">Ohar JA, Donohue JF, Spangenthal S. The Role of Guaifenesin in the Management of Chronic Mucus Hypersecretion Associated with Stable Chronic Bronchitis: A Comprehensive Review. <span><span class="ref-journal">Chronic Obstr Pulm Dis. </span>2019 Oct 23;<span class="ref-vol">6</span>(4):341-9.</span> [<a href="/pmc/articles/PMC7006698/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7006698</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31647856" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31647856</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="article-159926.r2">Albrecht HH, Dicpinigaitis PV, Guenin EP. Role of guaifenesin in the management of chronic bronchitis and upper respiratory tract infections. <span><span class="ref-journal">Multidiscip Respir Med. </span>2017;<span class="ref-vol">12</span>:31.</span> [<a href="/pmc/articles/PMC5724298/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5724298</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29238574" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29238574</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="article-159926.r3">Journey JD, Agrawal S, Stern E. <span class="ref-journal">StatPearls [Internet].</span> StatPearls Publishing; Treasure Island (FL): Jun 26, 2023. Dextromethorphan Toxicity. 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Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy. <span><span class="ref-journal">Am J Obstet Gynecol. </span>2005 Feb;<span class="ref-vol">192</span>(2):633-9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15696014" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15696014</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="article-159926.r5"><span class="ref-journal">Drugs and Lactation Database (LactMed®) [Internet].</span> National Institute of Child Health and Human Development; Bethesda (MD): Dec 15, 2023. Dextromethorphan. [<a href="https://pubmed.ncbi.nlm.nih.gov/30000516" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30000516</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="article-159926.r6"><span class="ref-journal">Drugs and Lactation Database (LactMed®) [Internet].</span> National Institute of Child Health and Human Development; Bethesda (MD): Oct 31, 2018. Guaifenesin. [<a href="https://pubmed.ncbi.nlm.nih.gov/30000515" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30000515</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="article-159926.r7">Malesker MA, Callahan-Lyon P, Ireland B, Irwin RS., CHEST Expert Cough Panel. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report. <span><span class="ref-journal">Chest. </span>2017 Nov;<span class="ref-vol">152</span>(5):1021-1037.</span> [<a href="/pmc/articles/PMC6026258/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6026258</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28837801" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28837801</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="article-159926.r8">Karabacak M, Margetis K. Natural language processing reveals research trends and topics in The Spine Journal over two decades: a topic modeling study. <span><span class="ref-journal">Spine J. </span>2024 Mar;<span class="ref-vol">24</span>(3):397-405.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/37797843" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 37797843</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="article-159926.r9">Small E, Sandefur BJ. Acute renal failure after ingestion of guaifenesin and dextromethorphan. <span><span class="ref-journal">J Emerg Med. </span>2014 Jul;<span class="ref-vol">47</span>(1):26-9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24630853" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24630853</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="article-159926.r10">Kim E, Perlmutter M, Zweber H, Resch J. Bilateral nephrolithiasis following ingestion of guaifenesin and dextromethorphan. <span><span class="ref-journal">Urol Case Rep. </span>2023 Sep;<span class="ref-vol">50</span>:102481.</span> [<a href="/pmc/articles/PMC10344657/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC10344657</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/37455782" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 37455782</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="article-159926.r11">Martinak B, Bolis RA, Black JR, Fargason RE, Birur B. Dextromethorphan in Cough Syrup: The Poor Man's Psychosis. <span><span class="ref-journal">Psychopharmacol Bull. </span>2017 Sep 15;<span class="ref-vol">47</span>(4):59-63.</span> [<a href="/pmc/articles/PMC5601090/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5601090</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28936010" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28936010</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="article-159926.r12">Brown GR, McLaughlin K, Vaughn K. Identifying and treating patients with synthetic psychoactive drug intoxication. <span><span class="ref-journal">JAAPA. </span>2018 Aug;<span class="ref-vol">31</span>(8):1-5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/30048361" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30048361</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="article-159926.r13">Stanley M, Chippa V, Aeddula NR, Quintanilla Rodriguez BS, Adigun R. <span class="ref-journal">StatPearls [Internet].</span> StatPearls Publishing; Treasure Island (FL): Apr 16, 2023. Rhabdomyolysis. [<a href="https://pubmed.ncbi.nlm.nih.gov/28846335" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28846335</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>14.</dt><dd><div class="bk_ref" id="article-159926.r14">Green JL, Wang GS, Reynolds KM, Banner W, Bond GR, Kauffman RE, Palmer RB, Paul IM, Dart RC. Safety Profile of Cough and Cold Medication Use in Pediatrics. <span><span class="ref-journal">Pediatrics. </span>2017 Jun;<span class="ref-vol">139</span>(6)</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/28562262" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28562262</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>15.</dt><dd><div class="bk_ref" id="article-159926.r15">Francescangeli J, Karamchandani K, Powell M, Bonavia A. The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice. <span><span class="ref-journal">Int J Mol Sci. </span>2019 May 09;<span class="ref-vol">20</span>(9)</span> [<a href="/pmc/articles/PMC6539562/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6539562</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/31075831" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31075831</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>16.</dt><dd><div class="bk_ref" id="article-159926.r16">van Spronsen FJ, Blau N, Harding C, Burlina A, Longo N, Bosch AM. Phenylketonuria. <span><span class="ref-journal">Nat Rev Dis Primers. </span>2021 May 20;<span class="ref-vol">7</span>(1):36.</span> [<a href="/pmc/articles/PMC8591558/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8591558</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/34017006" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 34017006</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>17.</dt><dd><div class="bk_ref" id="article-159926.r17">Gershanik J, Boecler B, Ensley H, McCloskey S, George W. 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Two Cases of Dextromethorphan Overdose Reversed by Naloxone. <span><span class="ref-journal">Cureus. </span>2023 Feb;<span class="ref-vol">15</span>(2):e34501.</span> [<a href="/pmc/articles/PMC9983620/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC9983620</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/36874326" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 36874326</span></a>]</div></dd></dl></dl></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin">
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<b>Disclosure: </b>Rohan Kapuria declares no relevant financial relationships with ineligible companies.</p></div></dd></dl><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin">
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<b>Disclosure: </b>Nicole Winston declares no relevant financial relationships with ineligible companies.</p></div></dd></dl></dl></div></div></div><div class="fm-sec"><h2 id="_NBK604212_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><p class="contrib-group"><h4>Authors</h4><span itemprop="author">Rohan Kapuria</span><sup>1</sup>; <span itemprop="author">Nicole R. Winston</span><sup>2</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup> Medical College of Georgia</div><div class="affiliation"><sup>2</sup> Augusta University Medical College of Georgia</div><h3>Publication History</h3><p class="small">Last Update: <span itemprop="dateModified">May 25, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © 2025, StatPearls Publishing LLC.<p class="small">
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This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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(<a href="https://creativecommons.org/licenses/by-nc-nd/4.0/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=uri">
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http://creativecommons.org/licenses/by-nc-nd/4.0/
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</a>), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not required to obtain permission to distribute this article, provided that you credit the author and journal.
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</p></div></div><h3>Publisher</h3><p><a href="https://www.statpearls.com/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">StatPearls Publishing</a>, Treasure Island (FL)</p><h3>NLM Citation</h3><p>Kapuria R, Winston NR. Dextromethorphan Guaifenesin. [Updated 2024 May 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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