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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Mother To Baby | Fact Sheets [Internet]. Brentwood (TN): Organization of Teratology Information Specialists (OTIS); 1994-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/mtb/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-mtb-lrg.png" alt="Cover of Mother To Baby | Fact Sheets" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>Mother To Baby | Fact Sheets [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK603256_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK603256_dtls__"><div>Brentwood (TN): <a href="https://mothertobaby.org/fact-sheets/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">Organization of Teratology Information Specialists (OTIS)</a>; 1994-.</div></div><div class="half_rhythm"></div><div class="bk_noprnt"><form method="get" action="/books/n/mtb/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK603256_"><span class="title" itemprop="name">Berberina</span></h1><p class="small">Published online: June 2023.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="berberine-sp.berberine-sp_s_001"><div class="h2"></div><p>Esta hoja trata sobre la exposición a berberina en el embarazo y durante la lactancia. Esta información se basa en la literatura publicada disponible. No debe usarse como un sustituto de la atención médica o los consejos de su proveedor de atención de salud.</p><p>
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<b>
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<i>¿Qué es la berberina?</i>
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</b>
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</p><blockquote><p>La berberina es un ingrediente que se encuentra en muchas especies de plantas, como el hilo de oro, el huang lian, la uva de Oregón y el agracejo. Se ha utilizado para tratar muchas afecciones, como la diarrea, la diabetes y el colesterol alto. También se ha utilizado para bajar de peso.</p><p>La berberina está disponible como un suplemento que se vende sin receta. En general, se sugiere hablar con su proveedor de atención de salud antes de tomar cualquier suplemento. Muchos suplementos no se recomiendan durante el embarazo a menos que su proveedor de atención de salud se los haya recetado para tratar una afección médica. Esto se debe a que no están bien regulados ni estudiados para su uso durante el embarazo. Para obtener más detalles sobre los suplementos, consulte la hoja informativa en <a href="https://mothertobaby.org/es/hojas-informativas/productos-herbales/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://mothertobaby.org/es/hojas-informativas/productos-herbales/</a>.</p></blockquote><p>
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<b>
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<i>Tomo berberina. ¿Puede hacer que me resulte más difícil quedar embarazada?</i>
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</b>
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</p><blockquote><p>Se desconoce si la berberina puede dificultar el embarazo. Hay cierta información que sugiere que la berberina puede aumentar las tasas de fertilidad y embarazo en personas con síndrome de ovario poliquístico (SOP).</p></blockquote><p>
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<b>
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<i>¿Tomar berberina aumenta la probabilidad de aborto espontáneo?</i>
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</b>
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</p><blockquote><p>El aborto espontáneo es común y puede ocurrir en cualquier embarazo por muchas razones diferentes. No se sabe si la berberina aumenta la posibilidad de aborto espontáneo. Un estudio sugiere que la berberina puede causar contracciones uterinas y aborto espontáneo. Sin embargo, la información es muy limitada. Como puede haber muchas causas de aborto espontáneo, es difícil saber si una exposición, la condición médica u otros factores son la causa de un aborto espontáneo.</p></blockquote><p>
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<b>
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<i>¿Tomar berberina aumenta la probabilidad de defectos de nacimiento?</i>
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</b>
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</p><blockquote><p>Cada embarazo comienza con un 3-5% de probabilidad de tener un defecto de nacimiento. Esto se conoce como riesgo de fondo. Un informe que analizó 218 embarazos expuestos a huang lian (que contiene berberina) no mostró una mayor probabilidad de defectos de nacimiento por encima del riesgo de fondo.</p></blockquote><p>
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<b>
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<i>¿Tomar berberina durante el embarazo aumenta la probabilidad de otros problemas relacionados con el embarazo?</i>
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</b>
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</p><blockquote><p>No se han realizado estudios para ver si berberina aumenta la probabilidad de problemas relacionados con el embarazo, como parto prematuro (parto antes de la semana 37) o bajo peso al nacer (que pesa menos de 5 libras, 8 onzas [2500 gramos] al nacer).</p><p>La berberina puede cambiar la forma en que la bilirrubina (un pigmento amarillento que se produce durante la descomposición de los glóbulos rojos) se une a la albúmina sérica (la proteína principal del plasma sanguíneo). Esto puede causar una acumulación de bilirrubina en el cerebro, lo que puede provocar daño cerebral y otros problemas. Si bien la información sobre esto es muy limitada, un autor sugiere evitar las hierbas y los productos que contienen berberina durante el embarazo.</p></blockquote><p>
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<b>
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<i>¿Tomar berberina durante el embarazo afecta el comportamiento o aprendizaje futuro para el niño?</i>
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</b>
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</p><blockquote><p>No se han realizado estudios para ver si la berberina puede causar problemas de comportamiento o aprendizaje en el niño.</p></blockquote><p>La lactancia mientras se toma <i><b><i>berberina</i></b></i>:</p><blockquote><p>La berberina pasa a la leche materna, pero se desconoce cuánta pasa. Es posible que la berberina en la leche materna pueda causar una acumulación de bilirrubina en el cerebro del bebé, lo que puede provocar daño cerebral y otros problemas. Esto hace que la exposición a la berberina a través de la leche materna sea una preocupación, especialmente en los recién nacidos. Además, debido a que la berberina es un suplemento, no se recomienda su uso durante la lactancia a menos que su proveedor de atención de salud se lo haya recetado para tratar una afección médica. Asegúrese de hablar con su proveedor de atención de salud acerca de todas sus preguntas sobre la lactancia.</p></blockquote><p>
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<b>
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<i>Si un hombre toma berberina, ¿podría afectar la fertilidad (capacidad de embarazar a la pareja) o aumentar la probabilidad de defectos de nacimiento?</i>
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</b>
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</p><blockquote><p>No se han realizado estudios en humanos para ver si la berberina podría afectar la fertilidad masculina o aumentar la probabilidad de defectos de nacimiento por encima del riesgo de fondo. En general, es poco probable que las exposiciones que tienen los padres o donantes de esperma aumenten los riesgos de un embarazo. Para más información, consulte la hoja informativa de MotherToBaby acerca de Exposiciones Paternas en <a href="https://mothertobaby.org/es/hojas-informativas/exposiciones-paternas/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://mothertobaby.org/es/hojas-informativas/exposiciones-paternas/</a>.</p></blockquote></div><div id="R001"><h2 id="_R001_">Referencias Seleccionadas:</h2><ul class="simple-list"><li class="half_rhythm"><div class="bk_ref" id="c001">An
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Y, et al. 2014. The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment.
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Clin Endocrinol (Oxf),
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80(3):425-431. [<a href="https://pubmed.ncbi.nlm.nih.gov/23869585" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23869585</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c002">Chan
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E.
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1993. Displacement of bilirubin from albumin by berberine.
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Biol Neonate,
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63:201-208. [<a href="https://pubmed.ncbi.nlm.nih.gov/8513024" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8513024</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c003">Imanshahidi
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M, et al. 2008. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine.
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Phytother Res,
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22:999–1012. [<a href="https://pubmed.ncbi.nlm.nih.gov/18618524" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18618524</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="c004">Lampe
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KF.
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1999. Berberine. In DeSmet PAGM, Keller K, Hnsel R, Chandler RF. Adverse effects of herbal drugs, vol
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1: 97-103. Springer-Verlag, Berlin.</div></li><li class="half_rhythm"><div class="bk_ref" id="c005">Zhao
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S, et al. 2021. Effect and mechanism of berberine against polycystic ovary syndrome.
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Biomedicine & Pharmacotherapy,
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138:111468. [<a href="https://pubmed.ncbi.nlm.nih.gov/33740526" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33740526</span></a>]</div></li></ul></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> de OTIS, junio 2023.<p class="small">This work is available under the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported license (<a href="https://creativecommons.org/licenses/by-nc-nd/3.0/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=uri">CC BY-NC-ND 3.0</a>)</p></div><div class="small"><span class="label">Bookshelf ID: NBK603256</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38691042" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">38691042</a></span></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK603256/?report=reader">PubReader</a></li><li><a href="/books/NBK603256/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK603256" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK603256" style="display:none" title="Cite this Page"><div class="bk_tt">Mother To Baby | Fact Sheets [Internet]. Brentwood (TN): Organization of Teratology Information Specialists (OTIS); 1994-. Berberina. 2023 Jun.<span class="bk_cite_avail"></span></div></div></li><li><a href="/books/NBK603256/pdf/Bookshelf_NBK603256.pdf">PDF version of this page</a> (105K)</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Link to English version of this Fact Sheet</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li>
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class="invert">Review</span> Quimioterapia.</a><span class="source">[Mother To Baby | Fact Sheets. ...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Quimioterapia.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Mother To Baby | Fact Sheets. 1994</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/39038309" ref="ordinalpos=1&linkpos=5&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Miconazol.</a><span class="source">[Mother To Baby | Fact Sheets. 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