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<div class="main-content lit-style"><div class="body-content whole_rhythm"><div id="kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2" class="table"><h3><span class="label">Table 4. </span></h3><div class="caption"><p><i>KMT2E</i>-Related Neurodevelopmental Disorder: Treatment of Manifestations</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK602945/table/kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_1" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Manifestation/Concern</th><th id="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_2" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Treatment</th><th id="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_3" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Considerations/Other</th></tr></thead><tbody><tr><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Developmental delay /</b>
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<br />
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<b>Intellectual disability /</b>
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<br />
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<b>Neurobehavioral issues</b>
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</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="/books/NBK602945/#kmt2e-ndd.Developmental_Delay__Intellect" target="mainwindow">Developmental Delay / Intellectual Disability Management Issues</a>.</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Seizures</b>
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</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Standardized treatment w/ASM by experienced neurologist</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Many ASMs may be effective; none has been demonstrated effective specifically for this disorder.</div></li><li class="half_rhythm"><div>1 affected person experienced developmental regression while being treated w/ketogenic diet; more data is required to determine if ketogenic diet is contraindicated in this condition. <sup>1</sup></div></li><li class="half_rhythm"><div>Education of parents/caregivers <sup>2</sup></div></li></ul>
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</td></tr><tr><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Gastroesophageal reflux / Vomiting</b>
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</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Standard therapy per gastroenterologist</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_1" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Bowel dysmotility /</b>
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<br />
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<b>Constipation</b>
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</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_3" colspan="1" rowspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Sleep disturbance</b>
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</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Standard treatment per sleep medicine specialist</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">At least 1 affected person has been treated w/melatonin.</td></tr><tr><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Family/Community</b>
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</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Ensure appropriate social work involvement to connect families w/local resources, respite, & support.</div></li><li class="half_rhythm"><div>Coordinate care to manage multiple subspecialty appointments, equipment, medications, & supplies.</div></li></ul>
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</td><td headers="hd_h_kmt2e-ndd.T.kmt2erelated_neurodevelopmen_2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Ongoing assessment of need for palliative care involvement &/or home nursing</div></li><li class="half_rhythm"><div>Consider involvement in adaptive sports or <a href="https://www.specialolympics.org/" target="mainwindow" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Special Olympics</a>.</div></li></ul>
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</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">ASM = anti-seizure medication; OT = occupational therapy; PT = physical therapy</p></div></dd><dt>1. </dt><dd><div id="kmt2e-ndd.TF.4.1"><p class="no_margin">
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<a class="bk_pop" href="/books/NBK602945/#kmt2e-ndd.REF.odonnellluria.2019.1210" data-bk-pop-rid="/books/NBK602945/def-item/kmt2e-ndd.REF.odonnellluria.2019.1210/" data-bk-pop-others="">O'Donnell-Luria et al [2019]</a>
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</p></div></dd><dt>2. </dt><dd><div id="kmt2e-ndd.TF.4.2"><p class="no_margin">Education of parents/caregivers regarding common seizure presentations is appropriate. For information on non-medical interventions and coping strategies for children diagnosed with epilepsy, see <a href="https://www.epilepsy.com/tools-resources/forms-resources#Epilepsy-Foundation-Toolbox" target="mainwindow" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Epilepsy Foundation Toolbox</a>.</p></div></dd></dl></div></div></div><div id="bk_toc_contnr"></div></div></div>
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