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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Chlorambucil - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Chlorambucil">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2023/08/15">
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<meta name="citation_pmid" content="37603676">
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<meta name="citation_keywords" content="Chlorambucil">
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<meta name="citation_keywords" content="Ambochlorin">
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<meta name="citation_keywords" content="Leukeran">
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<meta name="citation_keywords" content="Chloraminophen">
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<meta name="citation_keywords" content="Chlorbutin">
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<meta name="citation_keywords" content="Chloraminophene">
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<meta name="citation_keywords" content="Chlorobutine">
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<meta name="citation_keywords" content="Amboclorin">
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<meta name="citation_keywords" content="Ecloril">
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<meta name="citation_keywords" content="Chlorbutine">
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<meta name="citation_keywords" content="Lympholysin">
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<meta name="citation_keywords" content="Chlocambucil">
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<meta name="citation_keywords" content="Linfolizin">
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<meta name="citation_keywords" content="Linfolysin">
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<meta name="citation_keywords" content="Elcoril">
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<meta name="citation_keywords" content="Phenylbutyric acid nitrogen mustard">
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<meta name="citation_keywords" content="Leukersan">
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<meta name="citation_keywords" content="Leukoran">
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<meta name="citation_keywords" content="Chloorambucol">
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<meta name="citation_keywords" content="Chlorambucilum">
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<meta name="citation_keywords" content="Chlorbutinum">
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<meta name="citation_keywords" content="Elcorin">
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<meta name="citation_keywords" content="Cb l348">
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<meta name="citation_keywords" content="4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid">
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<meta name="citation_keywords" content="Clorambucile">
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<meta name="citation_keywords" content="Clorambucilo">
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<meta name="citation_keywords" content="CB 1348">
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<meta name="DC.Title" content="Chlorambucil">
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<meta name="description" content="No information is available on the clinical use of chlorambucil during breastfeeding. Most sources consider breastfeeding to be contraindicated during maternal cytotoxic antineoplastic drug therapy, especially alkylating agents such as chlorambucil.[1,2] Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[3] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK594289_"><span class="title" itemprop="name">Chlorambucil</span></h1><p class="fm-aai"><a href="#_NBK594289_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 305-03-3</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/403415864" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=403415864" alt="image 403415864 in the ncbi pubchem database" /></a><div id="chlorambucil.Drug_Levels_and_Effects"><h2 id="_chlorambucil_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="chlorambucil.Summary_of_Use_during_Lacta"><h3>Summary of Use during Lactation</h3><p>No information is available on the clinical use of chlorambucil during breastfeeding. Most sources consider breastfeeding to be contraindicated during maternal cytotoxic antineoplastic drug therapy, especially alkylating agents such as chlorambucil.[<a class="bibr" href="#chlorambucil.REF.1" rid="chlorambucil.REF.1">1</a>,<a class="bibr" href="#chlorambucil.REF.2" rid="chlorambucil.REF.2">2</a>] Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[<a class="bibr" href="#chlorambucil.REF.3" rid="chlorambucil.REF.3">3</a>] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.</p></div><div id="chlorambucil.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="chlorambucil.Effects_in_Breastfed_Infant"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="chlorambucil.Effects_on_Lactation_and_Br"><h3>Effects on Lactation and Breastmilk</h3><p>Telephone follow-up study was conducted on 74 women who received cancer chemotherapy at one center during the second or third trimester of pregnancy to determine if they were successful at breastfeeding postpartum. Only 34% of the women were able to exclusively breastfeed their infants, and 66% of the women reported experiencing breastfeeding difficulties. This was in comparison to a 91% breastfeeding success rate in 22 other mothers diagnosed during pregnancy, but not treated with chemotherapy. Other statistically significant correlations included: 1. mothers with breastfeeding difficulties had an average of 5.5 cycles of chemotherapy compared with 3.8 cycles among mothers who had no difficulties; and 2. mothers with breastfeeding difficulties received their first cycle of chemotherapy on average 3.4 weeks earlier in pregnancy. None of the patients in the study received chlorambucil.[<a class="bibr" href="#chlorambucil.REF.4" rid="chlorambucil.REF.4">4</a>]</p></div><div id="chlorambucil.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="chlorambucil.REF.1">Pistilli
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B, Bellettini
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G, Giovannetti
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E, et al.
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Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding?
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Cancer Treat Rev
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2013;39:207-11. [<a href="https://pubmed.ncbi.nlm.nih.gov/23199900" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23199900</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="chlorambucil.REF.2">Janssen
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NM, Genta
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MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy and lactation.
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Arch Intern Med
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2000;160:610-9. [<a href="https://pubmed.ncbi.nlm.nih.gov/10724046" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10724046</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="chlorambucil.REF.3">Urbaniak
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C, McMillan
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A, Angelini
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M, et al.
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Effect of chemotherapy on the microbiota and metabolome of human milk, a case report.
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Microbiome
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2014;2:24. [<a href="/pmc/articles/PMC4109383/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4109383</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25061513" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25061513</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="chlorambucil.REF.4">Stopenski
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S, Aslam
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A, Zhang
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X, Cardonick
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E. After chemotherapy treatment for maternal cancer during pregnancy, is breastfeeding possible?
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Breastfeed Med
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2017;12:91-7. [<a href="https://pubmed.ncbi.nlm.nih.gov/28170295" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28170295</span></a>]</div></dd></dl></dl></div></div><div id="chlorambucil.Substance_Identification"><h2 id="_chlorambucil_Substance_Identification_">Substance Identification</h2><div id="chlorambucil.Substance_Name"><h3>Substance Name</h3><p>Chlorambucil</p></div><div id="chlorambucil.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>305-03-3</p></div><div id="chlorambucil.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antineoplastic Agents, Alkylating</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK594289_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">August 15, 2023</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Chlorambucil. [Updated 2023 Aug 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM431/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM606/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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