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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Teduglutide" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2023/09/15" /><meta name="citation_pmid" content="36701512" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK588745/" /><meta name="citation_keywords" content="Teduglutide" /><meta name="citation_keywords" content="Gattex" /><meta name="citation_keywords" content="ALX-0600" /><meta name="citation_keywords" content="(Gly2)GLP-2" /><meta name="citation_keywords" content="ALX 0600" /><meta name="citation_keywords" content="Gly(2)-GLP-2" /><meta name="citation_keywords" content="Glucagon-like peptide II (2-glycine) (human)" /><meta name="citation_keywords" content="[Gly2]GLP-2" /><meta name="citation_keywords" content="UNII-7M19191IKG" /><meta name="citation_keywords" content="Teduglutide-d8 (Phe-d8)" /><meta name="citation_keywords" content="GLP2-2G" /><meta name="citation_keywords" content="GTPL7049" /><meta name="citation_keywords" content="SCHEMBL20898050" /><meta name="citation_keywords" content="HSDB 8337" /><meta name="citation_keywords" content="7M19191IKG" /><meta name="citation_keywords" content="XHA92242" /><meta name="citation_keywords" content="s9935" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Teduglutide" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2023/09/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK588745/" /><meta name="description" content="Because it is a large protein molecule with a molecular weight of 3752 Da, the amount in milk is likely to be very low. Teduglutide is also poorly absorbed orally so absorption by a breastfed infant is unlikely. Two breastfed infants apparently experienced no adverse effects during maternal use of teduglutide, but no long-term data are available. Until more data are available, teduglutide should be used with careful infant monitoring during breastfeeding." /><meta name="og:title" content="Teduglutide" /><meta name="og:type" content="book" /><meta name="og:description" content="Because it is a large protein molecule with a molecular weight of 3752 Da, the amount in milk is likely to be very low. Teduglutide is also poorly absorbed orally so absorption by a breastfed infant is unlikely. Two breastfed infants apparently experienced no adverse effects during maternal use of teduglutide, but no long-term data are available. Until more data are available, teduglutide should be used with careful infant monitoring during breastfeeding." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK588745/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/teduglutide/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK588745/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK588745_"><span class="title" itemprop="name">Teduglutide</span></h1><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2023</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 197922-42-2</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/395398640" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=395398640" alt="image 395398640 in the ncbi pubchem database" /></a><div id="teduglutide.Drug_Levels_and_Effects"><h2 id="_teduglutide_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="teduglutide.Summary_of_Use_during_Lactat"><h3>Summary of Use during Lactation</h3><p>Because it is a large protein molecule with a molecular weight of 3752 Da, the amount in milk is likely to be very low. Teduglutide is also poorly absorbed orally so absorption by a breastfed infant is unlikely. Two breastfed infants apparently experienced no adverse effects during maternal use of teduglutide, but no long-term data are available. Until more data are available, teduglutide should be used with careful infant monitoring during breastfeeding.</p></div><div id="teduglutide.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="teduglutide.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>One mother used teduglutide during pregnancy and postpartum while breastfeeding. She breastfed her infant (extent not stated) for 6 months. No mention was made of any adverse effects in the infant.[<a class="bk_pop" href="#teduglutide.REF.1">1</a>]</p><p>A woman taking teduglutide because of removal of a portion of her gastrointestinal tract became pregnant and delivered a healthy infant. She breastfed her infant and the drug was restarted 1 month after delivery. She breastfed (extent not stated) her infant for another 4 months during treatment. The infant experienced no side effects during breastfeeding.[<a class="bk_pop" href="#teduglutide.REF.2">2</a>]</p></div><div id="teduglutide.Effects_on_Lactation_and_Bre"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="teduglutide.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="teduglutide.REF.1">Gentilini
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MV, Doeyo
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M, Ortega
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M, et al.
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Successful pregnancy in a patient with short bowel syndrome after surgical rehabilitation and sGLP-2 treatment: Novel report on endogenous GLP-2 levels at delivery and during breastfeeding.
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Therap Adv Gastroenterol
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2022;15:17562848221129787. [<a href="/pmc/articles/PMC9706046/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC9706046</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/36458051" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 36458051</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="teduglutide.REF.2">Lillienau
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J, Nilsson
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E, Vulcan
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A, Nilsson
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A.
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90: Use of teduglutide during breast-feeding after pregnancy in a patient with severe intestinal failure.
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Transplantation
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2023;107:53. doi:10.1097/01.tp.0000945816.46782.83 [<a href="http://dx.crossref.org/10.1097/01.tp.0000945816.46782.83" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl></div></div><div id="teduglutide.Substance_Identification"><h2 id="_teduglutide_Substance_Identification_">Substance Identification</h2><div id="teduglutide.Substance_Name"><h3>Substance Name</h3><p>Teduglutide</p></div><div id="teduglutide.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>197922-42-2</p></div><div id="teduglutide.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Incretins</p><p>Glucagon-Like Peptide-1 Agonists</p><p>GLP-1 Agonists</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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