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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="author" content="Harvey N. Mayrovitz" /><meta name="citation_title" content="Breast Cancer" /><meta name="citation_publisher" content="Exon Publications" /><meta name="citation_date" content="2022/08/06" /><meta name="citation_author" content="Harvey N. Mayrovitz" /><meta name="citation_pmid" content="36121977" /><meta name="citation_doi" content="10.36255/exon-publications-breast-cancer" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK583818/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Breast Cancer" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="Exon Publications" /><meta name="DC.Contributor" content="Harvey N. Mayrovitz" /><meta name="DC.Date" content="2022/08/06" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK583818/" /><meta name="description" content="Breast cancer has become the most diagnosed cancer globally, surpassing lung and prostate cancers. In 2020, 2.3 million females were diagnosed with breast cancer worldwide. The incidence and related mortality from breast cancer continue to grow despite remarkable advances in our understanding of the biology of breast cancer and the availability of better therapeutic options. Therapies currently used to treat metastatic breast cancer extend the survival and quality of life of patients, but they are not curative. Therefore, a better understanding of the mechanisms involved in metastatic dissemination is of pivotal importance. This book provides a unique blend of carefully presented and structured information covering a broad array of relevant breast cancer-related issues. The first eight chapters cover breast cancer epidemiology, etiology, subtypes, current and emerging surgical innovations to treat and image breast cancer, a description of noninvasive lymphedema assessment methods to detect and track this important treatment complication, and the potential role of platelets and galectins in breast cancer metastasis. The last five chapters are devoted to the description of forward-looking albeit potential breast cancer treatment possibilities. In this regard, different chapters of the book describe novel research on the potential of ubiquitin-specific protease 18 (USP-18), ribosomal protein S6 kinase 1 (RPS6K1), the lysosomal system, nanoparticles, and proteolysis target chimeras as therapeutic agents for breast cancer. The range of clinical and translational research of breast cancer presented in this book will be of interest to healthcare professionals, clinicians, and basic scientists." /><meta name="og:title" content="Breast Cancer" /><meta name="og:type" content="book" /><meta name="og:description" content="Breast cancer has become the most diagnosed cancer globally, surpassing lung and prostate cancers. In 2020, 2.3 million females were diagnosed with breast cancer worldwide. The incidence and related mortality from breast cancer continue to grow despite remarkable advances in our understanding of the biology of breast cancer and the availability of better therapeutic options. Therapies currently used to treat metastatic breast cancer extend the survival and quality of life of patients, but they are not curative. Therefore, a better understanding of the mechanisms involved in metastatic dissemination is of pivotal importance. This book provides a unique blend of carefully presented and structured information covering a broad array of relevant breast cancer-related issues. The first eight chapters cover breast cancer epidemiology, etiology, subtypes, current and emerging surgical innovations to treat and image breast cancer, a description of noninvasive lymphedema assessment methods to detect and track this important treatment complication, and the potential role of platelets and galectins in breast cancer metastasis. The last five chapters are devoted to the description of forward-looking albeit potential breast cancer treatment possibilities. In this regard, different chapters of the book describe novel research on the potential of ubiquitin-specific protease 18 (USP-18), ribosomal protein S6 kinase 1 (RPS6K1), the lysosomal system, nanoparticles, and proteolysis target chimeras as therapeutic agents for breast cancer. The range of clinical and translational research of breast cancer presented in this book will be of interest to healthcare professionals, clinicians, and basic scientists." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK583818/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-cod9780645332032-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/cod9780645332032/toc/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK583818/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/cod9780645332032/fm.s1/" title="Next page in this title">Next ></a></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="https://exonpublications.com/index.php/exon" title="Exon Publications" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-cod9780645332032-lrg.png" alt="Cover of Breast Cancer" /></a><div class="icnblk_cntnt"><h1 id="_NBK583818_"><span itemprop="name">Breast Cancer</span></h1><p class="contrib-group">Editor: <span itemprop="editor">Harvey N. Mayrovitz</span>, PhD.</p><a data-jig="ncbitoggler" href="#__NBK583818_ai__" style="border:0;text-decoration:none">Editor Information</a><div style="display:none" class="ui-widget" id="__NBK583818_ai__"><p class="contrib-group"><h4>Editors</h4>Editor: <span itemprop="editor">Harvey N. Mayrovitz</span>, PhD<sup>1</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup> Department of Medical Education, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, FL, USA</div></div><div class="half_rhythm">Brisbane (AU): <a href="https://exonpublications.com/index.php/exon" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">Exon Publications</span></a>; <span itemprop="datePublished">2022 Aug 6</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-0-6453320-3-2</span></div></div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK583818" data-jigconfig="modal:true">Copyright and
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Permissions</a></span></li></ul></div><div id="_ncbi_dlg_cpyrght_NBK583818" style="display:none" title="Copyright and Permissions"><div><div>Copyright© 2022 Exon Publications.</div><div class="half_rhythm"><div>Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). <a href="https://creativecommons.org/licenses/by-nc/4.0/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=uri">https://creativecommons.org/licenses/by-nc/4.0/</a>. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.</div></div></div></div><div class="bk_noprnt"><form method="get" action="/books/n/cod9780645332032/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div itemprop="description"><p>Breast cancer has become the most diagnosed cancer globally, surpassing lung and prostate cancers. In 2020, 2.3 million females were diagnosed with breast cancer worldwide. The incidence and related mortality from breast cancer continue to grow despite remarkable advances in our understanding of the biology of breast cancer and the availability of better therapeutic options. Therapies currently used to treat metastatic breast cancer extend the survival and quality of life of patients, but they are not curative. Therefore, a better understanding of the mechanisms involved in metastatic dissemination is of pivotal importance. This book provides a unique blend of carefully presented and structured information covering a broad array of relevant breast cancer-related issues. The first eight chapters cover breast cancer epidemiology, etiology, subtypes, current and emerging surgical innovations to treat and image breast cancer, a description of noninvasive lymphedema assessment methods to detect and track this important treatment complication, and the potential role of platelets and galectins in breast cancer metastasis. The last five chapters are devoted to the description of forward-looking albeit potential breast cancer treatment possibilities. In this regard, different chapters of the book describe novel research on the potential of ubiquitin-specific protease 18 (USP-18), ribosomal protein S6 kinase 1 (RPS6K1), the lysosomal system, nanoparticles, and proteolysis target chimeras as therapeutic agents for breast cancer. The range of clinical and translational research of breast cancer presented in this book will be of interest to healthcare professionals, clinicians, and basic scientists.</p></div><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK583818_toc_fm_s1" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK583818_toc_fm_s1"><a class="toc-item" href="/books/n/cod9780645332032/fm.s1/">Foreword</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_fm_s2"><a class="toc-item" href="/books/n/cod9780645332032/fm.s2/">Preface</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_fm_s3"><a class="toc-item" href="/books/n/cod9780645332032/fm.s3/">List of Contributors</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch1"><a class="toc-item" href="/books/n/cod9780645332032/Ch1/">1. The Epidemiology of Breast Cancer</a><div>Evelina Arzanova and Harvey N. Mayrovitz.</div><ul id="toc_lst_NBK583818_toc_Ch1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch1-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch1/#Ch1-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch1-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch1/#Ch1-sec2">BREAST CANCER RISKS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch1-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch1/#Ch1-sec3">BREAST CANCER INCIDENCE AND MORTALITY RATES BY COUNTRY OR REGION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch1-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch1/#Ch1-sec4">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch1-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch1/#Ch1-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch2"><a class="toc-item" href="/books/n/cod9780645332032/Ch2/">2. The Etiology of Breast Cancer</a><div>Claudia Admoun and Harvey N. Mayrovitz.</div><ul id="toc_lst_NBK583818_toc_Ch2" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch2-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch2/#Ch2-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch2-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch2/#Ch2-sec2">FACTORS AFFECTING BREAST CANCER RISK</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch2-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch2/#Ch2-sec3">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch2-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch2/#Ch2-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/">3. Subtypes of Breast Cancer</a><div>Erasmo Orrantia-Borunda, Patricia Anchondo-Nuñez, Lucero Evelia Acuña-Aguilar, Francisco Octavio Gómez-Valles, and Claudia Adriana Ramírez-Valdespino.</div><ul id="toc_lst_NBK583818_toc_Ch3" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/#Ch3-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/#Ch3-sec2">LUMINAL A SUBTYPE</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/#Ch3-sec3">LUMINAL B SUBTYPE</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/#Ch3-sec4">HER2 SUBTYPE</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/#Ch3-sec5">TNBC SUBTYPE</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/#Ch3-sec6">METASTASIS, OVERALL SURVIVAL, AND RELAPSE</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3-sec7"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/#Ch3-sec7">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch3-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch3/#Ch3-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/">4. Current Surgical Innovations in the Treatment of Breast Cancer</a><div>Jessica Crystal, Juan Mella-Catinchi, Kyle Xu, and Daniel Weingrad.</div><ul id="toc_lst_NBK583818_toc_Ch4" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-sec2">TUMOR LOCALIZATION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-sec3">LYMPH NODE LOCALIZATION AND PROCEDURES</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-sec4">ONCOPLASTIC SURGERY</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-sec5">INTRAOPERATIVE RADIATION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-sec6">BREAST RECONSTRUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-sec7"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-sec7">LYMPHATIC RECONSTRUCTION PROCEDURES</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-sec8"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-sec8">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch4-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch4/#Ch4-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/">5. Measuring Breast Cancer-Related Lymphedema</a><div>Harvey N. Mayrovitz.</div><ul id="toc_lst_NBK583818_toc_Ch5" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec2">BCRl INCIDENCE</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec3">ARM VOLUMES BASED ON MANUAL CIRCUMFERENCE MEASUREMENTS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec4">LIMB VOLUMES FROM AUTOMATED ARM CIRCUMFERENCE MEASUREMENTS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec5">BCRL THRESHOLDS BASED ON ARM DIFFERENTIALS OR CHANGES</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec6">BCRL ASSESSMENTS BASED ON WATER DISPLACEMENT METHODS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec7"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec7">BCRL ASSESSMENTS WITH BIOIMPEDANCE SPECTROSCOPY (BIS)</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec8"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec8">BCRL ASSESSMENTS BASED ON TISSUE DIELECTRIC CONSTANT (TDC)</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec9"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec9">IMAGING-BASED MEASUREMENT METHODS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-sec10"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-sec10">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch5-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch5/#Ch5-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch6"><a class="toc-item" href="/books/n/cod9780645332032/Ch6/">6. The Role of Breast Imaging in Pre- and Post-Definitive Treatment of Breast Cancer</a><div>Dedy Hermansyah and Naufal Nandita Firsty.</div><ul id="toc_lst_NBK583818_toc_Ch6" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch6-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch6/#Ch6-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch6-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch6/#Ch6-sec2">X-RAY-BASED BREAST IMAGING (XBI)</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch6-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch6/#Ch6-sec3">MAGNETIC FIELD-BASED BREAST IMAGING (MFBI)</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch6-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch6/#Ch6-sec4">ADDITIONAL BREAST CANCER IMAGING</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch6-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch6/#Ch6-sec5">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch6-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch6/#Ch6-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/">7. Platelets in Hematogenous Breast Cancer Metastasis: Partners in Crime</a><div>Savannah R. Free and Kermit L. Carraway, III.</div><ul id="toc_lst_NBK583818_toc_Ch7" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-sec2">PLATELETS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-sec3">PLATELETS AND THE PRIMARY TUMOR</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-sec4">PLATELETS AND CIRCULATING TUMOR CELLS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-sec5">PLATELETS AND DISTANT METASTASIS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-sec6">PLATELETS AND PARANEOPLASTIC COAGULOPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-sec7"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-sec7">PLATELETS AS A THERAPEUTIC TARGET IN BREAST CANCER</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-sec8"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-sec8">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch7-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch7/#Ch7-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/">8. Role of Galectins in Metastatic Breast Cancer</a><div>Jessie J. Grazier and Paul W. Sylvester.</div><ul id="toc_lst_NBK583818_toc_Ch8" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/#Ch8-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/#Ch8-sec2">GLYCOBIOLOGY</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/#Ch8-sec3">CELLULAR ADHESIONS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/#Ch8-sec4">GROWTH FACTORS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/#Ch8-sec5">GALECTINS</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/#Ch8-sec6">POSSIBLE TARGETS IN THE TREATMENT OF METASTATIC BREAST CANCER</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8-sec7"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/#Ch8-sec7">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch8-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch8/#Ch8-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/">9. Ubiquitin-Specific Peptidase 18: A Multifaceted Protein Participating in Breast Cancer</a><div>Angeles C. Tecalco-Cruz, Josué O. Ramírez-Jarquín, Jesús Zepeda-Cervantes, Helena Solleiro-Villavicencio, and María Jazmín Abraham-Juárez.</div><ul id="toc_lst_NBK583818_toc_Ch9" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec2">GENERALITIES OF UBIQUITIN SPECIFIC PEPTIDASE 18 (USP18)</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec3">IFN-I SIGNALING PATHWAY AND ITS REGULATION BY USP18</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec4">USP18 AS A REGULATOR OF PROTEIN ISGYLATION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec5">USP18 AS A REGULATOR OF ISGYLATION OF BREAST CANCER PROTEOME</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec6">USP18 AND BREAST CANCER MICROENVIRONMENT</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec7"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec7">EGF/EGFR SIGNALING AND USP18 IN BREAST CANCER</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec8"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec8">USP18 AND THE TREATMENT FOR BREAST CANCER</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec9"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec9">FUTURE CHALLENGES IN ELUCIADITING THE ROLE OF USP18 IN BREAST CANCER</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-sec10"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-sec10">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch9-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch9/#Ch9-references">REFERENCE</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch10"><a class="toc-item" href="/books/n/cod9780645332032/Ch10/">10. Nanomaterials for Breast Cancer</a><div>Erasmo Orrantia-Borunda, Lucero Evelia Acuña-Aguilar, and Claudia Adriana Ramírez-Valdespino.</div><ul id="toc_lst_NBK583818_toc_Ch10" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch10-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch10/#Ch10-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch10-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch10/#Ch10-sec2">CARBON NANOSTRUCTURES</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch10-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch10/#Ch10-sec3">FUTURE PERSPECTIVES</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch10-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch10/#Ch10-sec4">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch10-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch10/#Ch10-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/">11. Targeting RPS6K1 for Refractory Breast Cancer Therapy</a><div>Jayalakshmi Sridhar, Rajesh Komati, and Satyendra Kumar.</div><ul id="toc_lst_NBK583818_toc_Ch11" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-sec2">S6K1 STRUCTURE AND REGULATION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-sec3">S6K1 AND BREAST CANCER</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-sec4">TARGETING S6K1 FOR BREAST CANCER THERAPY</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-sec5">PF-4708671</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-sec6">FS-115</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-sec7"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-sec7">LY2584702</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-sec8"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-sec8">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch11-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch11/#Ch11-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch12"><a class="toc-item" href="/books/n/cod9780645332032/Ch12/">12. Novel Breast Cancer Treatment by Targeting Estrogen Receptor-Alpha Stability Using Proteolysis-Targeting Chimeras (PROTACs) Technology</a><div>Angeles C. Tecalco-Cruz, Josué Orlando Ramírez-Jarquín, Marina Macías-Silva, Marcela Sosa-Garrocho, and César López-Camarillo.</div><ul id="toc_lst_NBK583818_toc_Ch12" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch12-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch12/#Ch12-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch12-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch12/#Ch12-sec2"><i>ESR1</i> MUTATIONS IN BREAST CANCER</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch12-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch12/#Ch12-sec3">ERα STABILITY AS A MECHANISM THAT PROMOTES PRO-TUMOR ACTIONS AND ENDOCRINE RESISTANCE</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch12-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch12/#Ch12-sec4">NOVEL PROTAC TECHNOLOGY FOR BREAST CANCER TREATMENT</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch12-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch12/#Ch12-sec5">DISCUSSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch12-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch12/#Ch12-sec6">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch12-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch12/#Ch12-references">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/">13. Engaging the Lysosome and Lysosome-Dependent Cell Death in Cancer</a><div>Anastasia L. Berg, Ashley Rowson-Hodel, Madelyn R. Wheeler, Michelle Hu, Savannah R. Free, and Kermit L. Carraway, III.</div><ul id="toc_lst_NBK583818_toc_Ch13" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13-sec1"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/#Ch13-sec1">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13-sec2"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/#Ch13-sec2">LYSOSOMAL STRUCTURE, DISTRIBUTION, AND IDENTIFICATION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13-sec3"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/#Ch13-sec3">LYSOSOME COMPOSITION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13-sec4"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/#Ch13-sec4">LYSOSOMES IN CELL DEATH</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13-sec5"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/#Ch13-sec5">LYSOSOMES IN CANCER</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13-sec6"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/#Ch13-sec6">MODULATION OF LMP AND ITS THERAPEUTIC POTENTIAL</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13-sec7"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/#Ch13-sec7">CONCLUSION</a></li><li class="half_rhythm" id="toc_itm_NBK583818_toc_Ch13-references"><a class="toc-item" href="/books/n/cod9780645332032/Ch13/#Ch13-references">REFERENCES</a></li></ul></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div><p>Dr. Harvey N. Mayrovitz did his PhD graduate work at the University of Pennsylvania and trained at Temple University School of Medicine and the Graduate Hospital in Philadelphia and at the Medical Faculty and Hospital in Rotterdam and Delft University in the Netherlands. In 1998, after serving as the Director of Cardiovascular Research at the Miami Heart Research Institute in Miami Beach Florida, he joined Nova Southeastern University in Ft. Lauderdale Florida where he is now a professor of physiology in the Dr. Kiran C. Patel College of Allopathic Medicine in the Department of Medical Education. His teaching areas include cardiovascular and pulmonary physiology directed toward medical and graduate health-science students. His current research areas include cardiopulmonary, lymphedema, and mostly noninvasive clinical and biophysical studies for diagnosis and therapy. He has authored over 150 scientific publications in these and related areas along with multiple book chapters. He continues his research activities and student mentoring with the most current research focused on developing ways to assess and better understand processes associated with lymphedema detection, progression, and its treatment. He is also actively investigating the potential of various forms of electromagnetic energy to influence blood flow and other physiological parameters.</p></div><div><p>
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<b>Breast Cancer</b>
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</p><p>ISBN: 978-0-6453320-3-2</p><p>DOI: <a href="https://doi.org/10.36255/exon-publications-breast-cancer" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://doi.org/10.36255/exon-publications-breast-cancer</a></p><p>
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<b>Edited by</b>
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</p><p>Harvey N. Mayrovitz, PhD, Department of Medical Education, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, FL, USA</p><p>
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<b>Published by</b>
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</p><p>Exon Publications, Brisbane, Australia</p><p>
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<b>Copyright© 2022 Exon Publications</b>
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</p><p>Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). <a href="https://creativecommons.org/licenses/by-nc/4.0/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://creativecommons.org/licenses/by-nc/4.0/</a>. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.</p><p>
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<b>Notice to the user</b>
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</p><p>The views and opinions expressed in this book are believed to be accurate at the time of publication. The publisher, editors or authors cannot be held responsible or liable for any errors, omissions or consequences arising from the use of the information contained in this book. The publisher makes no warranty, implicit or explicit, with respect to the contents of this book, or its use.</p><p>First Published in August 2022</p></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a>© 2022 Exon Publications.<p class="small">Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). <a href="https://creativecommons.org/licenses/by-nc/4.0/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=uri">https://creativecommons.org/licenses/by-nc/4.0/</a>. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.</p></div><div class="small"><span class="label">Bookshelf ID: NBK583818</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/36121977" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">36121977</a></span>DOI: <a href="http://dx.crossref.org/10.36255/exon-publications-breast-cancer" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">10.36255/exon-publications-breast-cancer</a></div><div style="margin-top:2em" class="bk_noprnt"><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/cod9780645332032/fm.s1/" title="Next page in this title">Next ></a></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK583818/?report=reader">PubReader</a></li><li><a href="/books/NBK583818/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK583818" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK583818" style="display:none" title="Cite this Page"><div class="bk_tt">Mayrovitz HN, editor. Breast Cancer [Internet]. Brisbane (AU): Exon Publications; 2022 Aug 6. <span class="bk_cite_avail"></span> doi: 10.36255/exon-publications-breast-cancer</div></div></li><li><a href="/books/n/cod9780645332032/pdf/">PDF version of this title</a> (27M)</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related Items in Bookshelf</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="https://www.ncbi.nlm.nih.gov/books?term=%22reference%20works%22%5BResource%20Type%5D" ref="pagearea=source-links&targetsite=external&targetcat=link&targettype=uri">All Reference Works</a></li><li><a href="https://www.ncbi.nlm.nih.gov/books?term="textbooks"%5BResource%20Type%5D" ref="pagearea=source-links&targetsite=external&targetcat=link&targettype=uri">All Textbooks</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=nlmcatalog&DbFrom=books&Cmd=Link&LinkName=books_nlmcatalog&IdsFromResult=5368494" ref="log$=recordlinks">NLM Catalog</a><div class="brieflinkpop offscreen_noflow">Related NLM Catalog Entries</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/17993229" ref="ordinalpos=1&linkpos=1&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Overview of resistance to systemic therapy in patients with breast cancer.</a><span class="source">[Adv Exp Med Biol. 2007]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Overview of resistance to systemic therapy in patients with breast cancer.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Gonzalez-Angulo AM, Morales-Vasquez F, Hortobagyi GN. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Adv Exp Med Biol. 2007; 608:1-22. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/33036834" ref="ordinalpos=1&linkpos=2&log$=relatedarticles&logdbfrom=pubmed">The future of Cochrane Neonatal.</a><span class="source">[Early Hum Dev. 2020]</span><div class="brieflinkpop offscreen_noflow">The future of Cochrane Neonatal.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Soll RF, Ovelman C, McGuire W. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Early Hum Dev. 2020 Nov; 150:105191. 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<title>Youtube</title>
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<style type="text/css">
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<path class="st5" d="M88.4,1037.4c-10.4,0-18.7,8.3-18.7,18.7v40.1c0,10.4,8.3,18.7,18.7,18.7h72.1c10.4,0,18.7-8.3,18.7-18.7 v-40.1c0-10.4-8.3-18.7-18.7-18.7H88.4z M115.2,1058.8l29.4,17.4l-29.4,17.4V1058.8z"></path>
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<p class="address_footer text-white">National Library of Medicine<br />
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<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
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Bethesda, MD 20894</a></p>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
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<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
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<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
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<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
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<nav class="bottom-links">
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<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
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<a class="text-white" href="https://www.nih.gov/">NIH</a>
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<a class="text-white" href="https://www.hhs.gov/">HHS</a>
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