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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Diazoxide" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2022/06/20" /><meta name="citation_pmid" content="35442606" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK579618/" /><meta name="citation_keywords" content="Diazoxide" /><meta name="citation_keywords" content="Proglycem" /><meta name="citation_keywords" content="Hyperstat" /><meta name="citation_keywords" content="Diazossido" /><meta name="citation_keywords" content="Diazoxido" /><meta name="citation_keywords" content="Diazoxidum [INN-Latin]" /><meta name="citation_keywords" content="Dizoxide" /><meta name="citation_keywords" content="EINECS 206-668-1" /><meta name="citation_keywords" content="Eudemine" /><meta name="citation_keywords" content="Hypertonalum" /><meta name="citation_keywords" content="Mutabase" /><meta name="citation_keywords" content="NSC 64198" /><meta name="citation_keywords" content="NSC 76130" /><meta name="citation_keywords" content="Proglicem" /><meta name="citation_keywords" content="Sch 6783" /><meta name="citation_keywords" content="SRG 95213" /><meta name="citation_keywords" content="UNII-O5CB12L4FN" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Diazoxide" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2022/06/20" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK579618/" /><meta name="description" content="Limited information indicates that maternal doses of oral diazoxide up to 175 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants. If oral diazoxide is required by the mother, it is not a reason to discontinue breastfeeding. Monitoring of the infant’s blood glucose may be advisable, especially during the newborn period." /><meta name="og:title" content="Diazoxide" /><meta name="og:type" content="book" /><meta name="og:description" content="Limited information indicates that maternal doses of oral diazoxide up to 175 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants. If oral diazoxide is required by the mother, it is not a reason to discontinue breastfeeding. Monitoring of the infant’s blood glucose may be advisable, especially during the newborn period." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK579618/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/diazoxide/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK579618/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK579618_"><span class="title" itemprop="name">Diazoxide</span></h1><p class="small">Last Revision: <span itemprop="dateModified">June 20, 2022</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 364-98-7</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/403034399" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=403034399" alt="image 403034399 in the ncbi pubchem database" /></a><div id="diazoxide.Drug_Levels_and_Effects"><h2 id="_diazoxide_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="diazoxide.Summary_of_Use_during_Lactatio"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that maternal doses of oral diazoxide up to 175 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants. If oral diazoxide is required by the mother, it is not a reason to discontinue breastfeeding. Monitoring of the infant’s blood glucose may be advisable, especially during the newborn period.</p></div><div id="diazoxide.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A woman with nesidioblastosis hypoglycemia had been on diazoxide for 30 years since the age of 4 months. Diazoxide was stopped during her pregnancies, but reinstated at week 25 of her second pregnancy in a dose of 50 mg three times daily and later the dosage schedule was 50 mg, 50 mg and 75 mg after her third meal of the day. Milk samples were taken 6 times between day 3 and day 8 postpartum. The highest concentrations in milk were 2.4 mg/L at 3 hours after a 50 mg dose and 3.1 mg/L at 3.4 hours after a 75 mg dose. The lowest measured level was 0.7 mg/L at 9 hours after a 75 mg dose.[<a class="bk_pop" href="#diazoxide.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="diazoxide.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>One infant was partially breastfed (10 to 50% initially, then 80% at 1 month of age) by a mother taking diazoxide orally in dosages of 150 to 175 mg daily for hypoglycemia. At 30 days of age, the infant was developing normally and had experienced no episodes of hypo- or hyperglycemia.[<a class="bk_pop" href="#diazoxide.REF.1">1</a>]</p></div><div id="diazoxide.Effects_on_Lactation_and_Breas"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="diazoxide.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="diazoxide.REF.1">Saito J, Kawasaki H, Adachi N, et al. Diazoxide during pregnancy and lactation: drug levels in maternal serum, cord blood, breast milk, and infant serum: A case report. <span><span class="ref-journal">Gynecol Endocrinol. </span>2022;<span class="ref-vol">38</span>:528–30.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/35403531" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35403531</span></a>]</div></dd></dl></div></div><div id="diazoxide.Substance_Identification"><h2 id="_diazoxide_Substance_Identification_">Substance Identification</h2><div id="diazoxide.Substance_Name"><h3>Substance Name</h3><p>Diazoxide</p></div><div id="diazoxide.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>364-98-7</p></div><div id="diazoxide.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antihypertensive Agents</p><p>Vasodilator Agents</p><p>Blood Glucose</p><p>Glycemic Control</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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