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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Teriparatide" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2025/01/15" /><meta name="citation_pmid" content="35442604" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK579616/" /><meta name="citation_keywords" content="Teriparatide" /><meta name="citation_keywords" content="Forteo" /><meta name="citation_keywords" content="Parathar" /><meta name="citation_keywords" content="1-34)-Human parathyroid hormone" /><meta name="citation_keywords" content="1-34-Human PTH" /><meta name="citation_keywords" content="1-34-Parathormone (human)" /><meta name="citation_keywords" content="rhPTH(1-34)" /><meta name="citation_keywords" content="rhPTH1-34" /><meta name="citation_keywords" content="MN 10T" /><meta name="citation_keywords" content="Parathyroid hormone peptide (1-34)" /><meta name="citation_keywords" content="Teriparatida" /><meta name="citation_keywords" content="Teriparatidum" /><meta name="citation_keywords" content="UNII-10T9CSU89I" /><meta name="citation_keywords" content="ZT 034" /><meta name="citation_keywords" content="ZT-034" /><meta name="citation_keywords" content="L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine" /><meta name="citation_keywords" content="palopegteriparatide" /><meta name="citation_keywords" content="Yorvipath" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Teriparatide" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2025/01/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK579616/" /><meta name="description" content="One infant with congenital hyperparathyroidism was breastfed during maternal use of teriparatide. The infant appeared to be protected against hypoparathyroidism by breastfeeding. Because of the potential for osteosarcoma in animal studies, the manufacturer of teriparatide advises that breastfeeding is not recommended during treatment with teriparatide. Palopegteriparatide is a prodrug of teriparatide and should have similar concerns during breastfeeding. Neither drug is absolutely contraindicated during breastfeeding. If one of these drugs is used in a nursing mother, monitor breastfed infants for signs and symptoms of hypercalcemia or hypocalcemia. Serum calcium monitoring should also be considered." /><meta name="og:title" content="Teriparatide" /><meta name="og:type" content="book" /><meta name="og:description" content="One infant with congenital hyperparathyroidism was breastfed during maternal use of teriparatide. The infant appeared to be protected against hypoparathyroidism by breastfeeding. Because of the potential for osteosarcoma in animal studies, the manufacturer of teriparatide advises that breastfeeding is not recommended during treatment with teriparatide. Palopegteriparatide is a prodrug of teriparatide and should have similar concerns during breastfeeding. Neither drug is absolutely contraindicated during breastfeeding. If one of these drugs is used in a nursing mother, monitor breastfed infants for signs and symptoms of hypercalcemia or hypocalcemia. Serum calcium monitoring should also be considered." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK579616/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/teriparatide/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK579616/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK579616_"><span class="title" itemprop="name">Teriparatide</span></h1><p class="small">Last Revision: <span itemprop="dateModified">January 15, 2025</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 52232-67-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/254778679" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=254778679" alt="image 254778679 in the ncbi pubchem database" /></a><div id="teriparatide.Drug_Levels_and_Effects"><h2 id="_teriparatide_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="teriparatide.Summary_of_Use_during_Lacta"><h3>Summary of Use during Lactation</h3><p>One infant with congenital hyperparathyroidism was breastfed during maternal use of teriparatide. The infant appeared to be protected against hypoparathyroidism by breastfeeding. Because of the potential for osteosarcoma in animal studies, the manufacturer of teriparatide advises that breastfeeding is not recommended during treatment with teriparatide. Palopegteriparatide is a prodrug of teriparatide and should have similar concerns during breastfeeding. Neither drug is absolutely contraindicated during breastfeeding. If one of these drugs is used in a nursing mother, monitor breastfed infants for signs and symptoms of hypercalcemia or hypocalcemia. Serum calcium monitoring should also be considered.</p></div><div id="teriparatide.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="teriparatide.Effects_in_Breastfed_Infant"><h3>Effects in Breastfed Infants</h3><p>A woman with autosomal dominant hypoparathyroidism type 1 (ADH1) was treated with teriparatide 28 mcg daily by continuous infusion during pregnancy. She also took vitamin D3 1000 IU daily, magnesium oxide 400 mg twice daily, and calcium carbonate 0 to 3 grams orally depending on serum calcium. The infusion was continued for 8 months postpartum in doses ranging from 27 to 30 mcg daily when calcitriol 0.5 mcg twice daily was substituted. She breastfed her infant exclusively for 6 months then with supplementation to 1 year. Her infant had no change in serum calcium when maternal calcitriol was begun. The mother began weaning at 11 months and at 1 year of age when weaning was complete, her infant developed hypocalcemia and was diagnosed with ADH1 and the same genetic mutation as her mother and other family members. Serum parathyroid hormone-related protein levels in the infant were in the mid-normal range during the first year while nursing. A single sample drawn after weaning showed her level had dropped markedly. The breastfed infant appeared to be protected from severe hypocalcemia during the first year of life by the mother’s breastmilk. Growth and development were normal at 1.5 years of age.[<a class="bk_pop" href="#teriparatide.REF.1">1</a>]</p></div><div id="teriparatide.Effects_on_Lactation_and_Br"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="teriparatide.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>
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<a href="/books/n/lactmed/parathyroid_hormone/">Parathyroid Hormone</a>
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</p></div><div id="teriparatide.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="teriparatide.REF.1">Shulman
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D.
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Subcutaneous infusion of rhPTH(1-34) during pregnancy and nursing in a woman with autosomal dominant hypoparathyroidism 1.
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J Endocr Soc
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2022;6:bvac031.
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[<a href="/pmc/articles/PMC8944315/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8944315</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/35350394" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35350394</span></a>]</div></dd></dl></div></div><div id="teriparatide.Substance_Identification"><h2 id="_teriparatide_Substance_Identification_">Substance Identification</h2><div id="teriparatide.Substance_Name"><h3>Substance Name</h3><p>Teriparatide</p></div><div id="teriparatide.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>52232-67-4</p></div><div id="teriparatide.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Parathyroid Hormone</p><p>Calcium-Regulating Hormones and Agents</p><p>Bone Density Conservation Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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