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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="https://www.nice.org.uk" title="National Institute for Health and Care Excellence (NICE)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng87er6-lrg.png" alt="Cover of Evidence review for combined pharmacological and non-pharmacological treatments review" /></a><div class="icnblk_cntnt"><h1 id="_NBK578099_"><span itemprop="name">Evidence review for combined pharmacological and non-pharmacological treatments review</span></h1><div class="subtitle">Attention deficit hyperactivity disorder: diagnosis and management</div><p><b>Evidence review F</b></p><p><i>NICE Guideline, No. 87</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Guideline Centre (UK)</span>.</p><div class="half_rhythm">London: <a href="https://www.nice.org.uk" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2018 Mar</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-2830-9</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2018.</div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div id="ch6.s1"><h2 id="_ch6_s1_">1. Combined pharmacological and non-pharmacological treatments</h2><div id="ch6.s1.1"><h3>1.1. Review question: What is the most clinically and costeffective combination of pharmacological and nonpharmacological treatment for people with ADHD?</h3></div><div id="ch6.s1.2"><h3>1.2. Introduction</h3><p>Combining medication and non-pharmacological therapy has the potential to increase effectiveness compared with one treatment alone. In people with ADHD combining treatments may increase effects on core ADHD symptoms through the interaction of the two approaches. The potential value of combining medication and non-pharmacological therapy for people with ADHD might lead to beneficial effects in different domains. For example, medication targeting the core ADHD symptoms such as inattention and hyperactivity/impulsivity, and psychosocial interventions targeting secondary problems and coexisting conditions associated with ADHD. Combining pharmacological and non-pharmacological approaches may also have the potential to deliver both immediate effects on ADHD symptoms through medication, along with more long-lasting effects through the development of behavioural and cognitive skills and strategies. This review evaluates the evidence on the use of combined interventions where medication and non-pharmacological therapies are used together to treat ADHD and while the two approaches are complimentary head to head comparisons between the two are evaluated.</p><p>This review should be read alongside <a href="/books/n/niceng87er3/" class="toc-item">evidence review C</a> on pharmacological efficacy and sequencing, <a href="/books/n/niceng87er4/" class="toc-item">evidence report D</a> on pharmacological safety and <a href="/books/n/niceng87er5/" class="toc-item">evidence report E</a> on non-pharmacological efficacy and adverse events.</p></div><div id="ch6.s1.3"><h3>1.3. PICO table</h3><p>For full details see the review protocol in <a href="#ch6.appa">appendix A</a>.</p></div><div id="ch6.s1.4"><h3>1.4. Methods and process</h3><p>This evidence review was developed using the methods and process described in Developing NICE guidelines: the manual.<a class="bk_pop" href="#ch6.r46"><sup>46</sup></a> Methods specific to this review question are described in the review protocol in <a href="#ch6.appa">appendix A</a>.</p><p>Declarations of interest were recorded according to NICE’s 2014 conflicts of interest policy.</p><p>Evidence was divided into the following categories:
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<ul id="ch6.l3"><li id="ch6.lt11" class="half_rhythm"><div>Non-pharmacological treatments versus pharmacological treatments</div></li><li id="ch6.lt12" class="half_rhythm"><div>Combined treatments versus non-pharmacological treatments</div></li><li id="ch6.lt13" class="half_rhythm"><div>Combined treatments versus pharmacological treatments</div></li><li id="ch6.lt14" class="half_rhythm"><div>Combined treatments versus no treatment/treatment as usual</div></li><li id="ch6.lt15" class="half_rhythm"><div>Combined treatments versus any other combined treatment</div></li></ul></p><p>Studies were not included if they systematically selected a population who were responders to the primary treatment under investigation (for example a population of only responders to methylphenidate randomised to CBT alone or CBT with methylphenidate).</p><p>Evidence was separated into short term (under 3 months) and longer term (greater than 3 months. Evidence was also separated into whether the outcomes were assessed at the end of treatment (post-treatment (PT)) or at the end of a follow-up period beyond the treatment (follow-up (FU)).</p><p>A network meta-analysis was considered for this question but deemed inappropriate due to concerns over differences in trial populations, exact trial interventions and insufficient data available for the relevant outcomes (see the methodology chapter for further details). Although it was not deemed appropriate to conduct an NMA across the entirety of the clinical review, in order to pragmatically obtain the best possible evidence for the select areas in which health economic modelling was feasible and a high priority, a more restricted NMA was conducted. Please see Appendix 3 for more information</p></div><div id="ch6.s1.5"><h3>1.5. Clinical evidence</h3><div id="ch6.s1.5.1"><h4>1.5.1. Included studies</h4><p>Thirty-three studies (in 35 publications) were included in the review;<a class="bk_pop" href="#ch6.r1"><sup>1</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r3"><sup>3</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r9"><sup>9</sup></a><sup>–</sup><a class="bk_pop" href="#ch6.r13"><sup>13</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r17"><sup>17</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r20"><sup>20</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r21"><sup>21</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r24"><sup>24</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r26"><sup>26</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r28"><sup>28</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r34"><sup>34</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r36"><sup>36</sup></a><sup>–</sup><a class="bk_pop" href="#ch6.r38"><sup>38</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r41"><sup>41</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r43"><sup>43</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r44"><sup>44</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r49"><sup>49</sup></a><sup>–</sup><a class="bk_pop" href="#ch6.r52"><sup>52</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r54"><sup>54</sup></a><sup>–</sup><a class="bk_pop" href="#ch6.r56"><sup>56</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r59"><sup>59</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r61"><sup>61</sup></a><sup>–</sup><a class="bk_pop" href="#ch6.r63"><sup>63</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r65"><sup>65</sup></a><sup>–</sup><a class="bk_pop" href="#ch6.r68"><sup>68</sup></a> these are summarised in <a class="figpopup" href="/books/NBK578099/table/ch6.tab2/?report=objectonly" target="object" rid-figpopup="figch6tab2" rid-ob="figobch6tab2">Table 2</a> and <a class="figpopup" href="/books/NBK578099/table/ch6.tab3/?report=objectonly" target="object" rid-figpopup="figch6tab3" rid-ob="figobch6tab3">Table 3</a> below. Evidence from these studies is summarised in the clinical evidence summary tables below.</p><p>See also the study selection flow chart in <a href="#ch6.appc">appendix C</a>, study evidence tables in <a href="#ch6.appd">appendix D</a>, forest plots in <a href="#ch6.appe">appendix E</a> and GRADE tables in <a href="#ch6.appf">appendix F</a>.</p><p>There were 0 studies in the under 5 year old category 23 studies in the 5 to 18 year old category and 10 studies in >18 year old category.</p><p>The majority of studies (n=23) compared combination to pharmacological interventions, 13 compared combination to non-pharmacological interventions, 8 compared pharmacological to non-pharmacological, 4 compared combination to usual care and 1 compared combination to another combination.</p><p>A number of studies included more than two arms and therefore contributed to more than one comparison.</p></div><div id="ch6.s1.5.2"><h4>1.5.2. Excluded studies</h4><p>See the excluded studies list in <a href="#ch6.appi">appendix I</a>.</p></div><div id="ch6.s1.5.3"><h4>1.5.3. Summary of clinical studies included in the evidence review</h4><p>See <a href="#ch6.appd">appendix D</a> for full evidence tables.</p></div><div id="ch6.s1.5.4"><h4>1.5.4. Quality assessment of clinical studies included in the evidence review</h4><div id="ch6.s1.5.4.1"><h5>1.5.4.1. Children and young people aged 5 to 18</h5><div id="ch6.s1.5.4.1.1"><h5>1.5.4.1.1. Pharmacological treatment versus non-pharmacological treatment in children and young people</h5></div><div id="ch6.s1.5.4.1.2"><h5>1.5.4.1.2. Combination versus non-pharmacological treatment in children and young people</h5></div><div id="ch6.s1.5.4.1.3"><h5>1.5.4.1.3. Combination versus pharmacological treatment in children and young people</h5></div><div id="ch6.s1.5.4.1.4"><h5>1.5.4.1.4. Combination versus no treatment/usual care in children and young people</h5></div><div id="ch6.s1.5.4.1.5"><h5>1.5.4.1.5. Combination versus other combined treatments in children and young people</h5></div></div><div id="ch6.s1.5.4.2"><h5>1.5.4.2. Adults over the age of 18</h5><div id="ch6.s1.5.4.2.1"><h5>1.5.4.2.1. Pharmacological treatment versus non-pharmacological treatment in adults</h5></div><div id="ch6.s1.5.4.2.2"><h5>1.5.4.2.2. Combination versus non-pharmacological treatment in adults</h5></div><div id="ch6.s1.5.4.2.3"><h5>1.5.4.2.3. Combination versus pharmacological treatment in adults</h5></div><div id="ch6.s1.5.4.2.4"><h5>1.5.4.2.4. Combination versus no treatment/usual care in adults</h5><p>See <a href="#ch6.appf">appendix F</a> for full GRADE tables.</p></div></div></div></div><div id="ch6.s1.6"><h3>1.6. Economic evidence</h3><div id="ch6.s1.6.1"><h4>1.6.1. Included studies</h4><div id="ch6.s1.6.1.1"><h5>2008 guideline literature</h5><p>One original model from CG72 in adults, looking at a combination of pharmacological and non-pharmacological treatments is included.</p><p>Details of the combination model in adults can be found in <a class="figpopup" href="/books/NBK578099/table/ch6.tab35/?report=objectonly" target="object" rid-figpopup="figch6tab35" rid-ob="figobch6tab35">Table 35</a>.</p></div><div id="ch6.s1.6.1.2"><h5>Published literature</h5><p>No relevant health economic studies were identified from the update search.</p><p>See also the health economic study selection flow chart in <a href="#ch6.appc">Appendix C</a>.</p></div></div><div id="ch6.s1.6.2"><h4>1.6.2. Excluded studies</h4><p>Four studies were included in CG72 that could be included in the combination review. All were in children.<a class="bk_pop" href="#ch6.r18"><sup>18</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r29"><sup>29</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r31"><sup>31</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r39"><sup>39</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r69"><sup>69</sup></a></p><p>All of these studies have been selectively excluded due to limited applicability and/or methodological limitations. These are listed in <a href="#ch6.appi">Appendix I</a>, with reasons for exclusion given.</p><p>One original model from CG72 in children, looking at a combination of pharmacological and non-pharmacological treatments, has been selectively excluded because the clinical evidence feeding into this model is not included in the guideline clinical review (see <a href="#ch6.appi">Appendix I</a> for more details), and will also be superseded by original modelling in children for this question.</p><p>See also the health economic study selection flow chart in <a href="#ch6.appg">appendix G</a>.</p></div><div id="ch6.s1.6.3"><h4>1.6.3. Summary of studies included in the economic evidence review</h4></div><div id="ch6.s1.6.4"><h4>1.6.4. Health economic model</h4><p>The previous guideline model evaluating combination treatments in comparison to medication alone or behavioural therapy alone, in children, was based on two studies that directly compared the three interventions. The focus was on stimulants as the medication. The question on combination treatments was decided as the first priority for economic modelling because there is a highly relevant trade-off with regards to whether the benefit of any additional interventions are worth the additional cost. It is also considered highly important in mental health for patients to have choices about what treatments they might prefer. Therefore, updating the previous model which sought to compare different types of treatments as well as the combination of the two, would help inform; the treatment pathway to be recommended as to whether there is a hierarchy regarding pharmacological and non-pharmacological treatments, and also whether the combination is cost effective.</p><p>There are three models replacing the previous combination model in children, as the clinical data identified from the combination review that had dichotomous outcomes needed for any models was sparse and the committee felt that some interventions couldn’t be combined together. An overview of the 3 models and their results are discussed below, with further detail in the write-up (Appendix 1).</p><div id="ch6.s1.6.4.1"><h5>1. Atomoxetine combination model</h5><div id="ch6.s1.6.4.1.1"><h5>Model overview</h5><p>Being evaluated in the model is the combination of Atomoxetine and (group) behavioural therapy, compared to Atomoxetine alone and behavioural therapy alone.</p><p>The model is a decision tree with a 1 year time horizon. Atomoxetine dose in the model is using a maintenance dose of 1.2mg/kg per day. Behavioural therapy consists of 10 weekly sessions of 1 hour of parent training with a clinical psychologist (in keeping with the behavioural therapy resource use in the parent training model). Combination treatment is the sum of both these interventions.</p><p>The population is children with ADHD, with an age range of 5-15 from the studies informing effect, with average ages of 8-11. They are mixed populations in the sense that some people in the trials have tried medication before, but there is no selective inclusion based only on previous non-response. Because patients begin treatment when they enter they model (as that was how the trials were set up) then in the interventions that include atomoxetine, there is a probability of withdrawal from the treatment because of intolerable side effects. At the end of duration of the trials (10 weeks), patients from all the treatments are either classified as responders or non-responders. Responders remain on the treatment (if it involves atomoxetine, because behavioural therapy is a short term treatment) and remain responding until the end of the model. Patients can also experience adverse events that are tolerable and do not cause them to withdraw from the treatment, but do lead to a decrement in quality of life. If a patient withdraws because of adverse events, or does not respond to the treatment and therefore stops the treatment, then they go on to what is referred to as ‘other treatment’. There are no adverse events assumed from behavioural therapy.</p><p>No further lines of treatment were modelled because assumptions would be needed about what these would be, and there is a lack of data on probabilities that are dependent on prior treatment choices. An overarching state of ‘other treatment’ was used as a catch-all to represent other treatment that patients might go on to, i.e. an overall probability of response in the general ADHD child population in which some people may be on a variety of treatments and some people may not be on any active treatment. The cost of ‘other treatment’ is represented only in terms of resource use (the number of consultations associated with responders and non-responders). This is because resource use in terms of staff consultations (with a psychiatrist or nurse) is already included as a key part of the cost of starting and continuing Atomoxetine, and therefore it made sense to continue including this resource use for the whole time horizon of the model so as not to bias against Atomoxetine or for not responding to be a cheaper outcome.</p></div><div id="ch6.s1.6.4.1.2"><h5>Data</h5><p>3 studies inform the treatment effect of this model, with an average trial duration of 10 weeks. One comparing all 3 comparisons<a class="bk_pop" href="#ch6.r21"><sup>21</sup></a>, one comparing the combination with atomoxetine alone<a class="bk_pop" href="#ch6.r65"><sup>65</sup></a>, and one study compared the combination with behavioural therapy alone<a class="bk_pop" href="#ch6.r58"><sup>58</sup></a>. Note that where an intervention from the studies had a placebo pill in combination with a behavioural therapy; for the purposes of the model this is being treated as only behavioural therapy. The studies had some differences in terms of intensity of treatments, population medication status, and scales used to define response. But they were combined because they included atomoxetine as the drug. The probabilities of response for each intervention were derived from a network meta-analysis of the three studies undertaken by the health economist for to inform the model. Probability of discontinuation and adverse events was taken from the guideline clinical review.</p><p>Resource use such as doses of atomoxetine during titration and maintenance, and staff costs associated with monitoring treatments as well as the staff costs associated with behavioural therapy were elicited from the committee. Utilities were from the same source as the parent training model, as for all the models in the guideline. The utility gain from response is assumed to increase linearly over the trial period to reflect that the effect may not be immediate.</p></div><div id="ch6.s1.6.4.1.3"><h5>Results</h5><p>The probabilistic base case results showed that behavioural therapy was the most cost effective because it had the highest net benefit, and also the ICERS of Atomoxetine compared to behavioural therapy (£44,175 per QALY), and combination treatment compared to Atomoxetine (£56,219 per QALY) were above the threshold of £20,000, demonstrating that the additional benefit does not justify the cost of the more expensive interventions.</p><p>Various sensitivity analyses were also explored; assuming the response from behavioural therapy decreases linearly from the end of treatment to end of the model for BT alone and combination arms. This showed behavioural therapy still had the highest net benefit, but atomoxetine had a lower ICER than in the base case. This is because reducing the effectiveness of behavioural therapy led to lower total QALYs for the other interventions. Another sensitivity analysis assumed behavioural therapy was individual rather than a group treatment; this increased the cost of the intervention to the extent that behavioural therapy was dominated by atomoxetine. Atomoxetine was now the most cost effective intervention because combination treatment had a very high ICER compared to atomoxetine (£399,620). A final sensitivity analysis also looked at using alternative sources of utility other than the EQ-5D. This showed that although the results were sensitive to changes in the QALY, behavioural therapy still had the highest net benefit.</p><p>This model aimed to compare the cost effectiveness of starting a combination of Atomoxetine and behavioural therapy, compared to starting Atomoxetine alone, or a course of behavioural therapy. Although Atomoxetine is a drug that would most likely not be at the beginning of the treatment pathway, the interventions included in the model are comparisons that were identified in the clinical review that had appropriate outcomes that could be utilised in a model. Therefore what the model is really answering is; in children who may be considering using atomoxetine, is it cost effective alone, or in combination with behavioural therapy, or is behavioural therapy alone the best choice in terms of cost effectiveness. What conclusions can be drawn from the model are highly dependent on the clinical data used, and the assumptions made about future pathways in the model and inputs such as resource use.</p><p>Limitations include; the clinical effect only being based on 3 studies. Bringing together the conclusions of dichotomous outcomes (what this model is based on) with the clinical review that used continuous outcomes is also a challenge as the two types of outcomes do not always agree. The committee opinion was that the clinical review in general is unlikely to have captured all the benefits of non-pharmacolgical treatment, because these are wider than just ADHD core symptoms. Other benefits also may not have been captured such as longer term impacts which are unknown, and the impact on other sectors. It was not possible to model all treatments individually and in sequences compared to each other and so assumptions (or the lack of) made about further treatment is also a limitation.</p></div></div><div id="ch6.s1.6.4.2"><h5>2. MPH + self-help behavioural therapy model</h5><div id="ch6.s1.6.4.2.1"><h5>Model overview</h5><p>This model is comparing staying on MPH if you are a partial responder versus adding telephone assisted self-help behavioural therapy in children. The model is interested in the added value of a behavioural therapy on top of medication. The intervention involved parents reading 8 self-help booklets dealing with disruptive behaviour disorders and parenting that were mailed to them approximately every 2 weeks. Parents received 10 phone consultations of about 30 minutes each in the first 6 months, and then 4 booster calls during the second 6 months.</p><p>The population is children with ADHD who are on a stable dose of MPH, but had functional impairment (in the study this was functional impairment in at least one of the domains of the Weiss Functional Impairment Rating Scale). This can be seen as the baseline population because children are on MPH in both the intervention and the control group.</p><p>This is based on a single study reporting outcomes at 12 months. The GC thought that analysing the cost effectiveness of this study would be useful because it is an intervention they envisaged could be used as a baseline intervention in current practice because; it is more longer term than the usual courses of behavioural therapy, it involves self-help and telephone consultations. Although, as the intervention will be provided on an individual basis, the cost of the behavioural therapy is likely to be high.</p><p>The model is a decision tree model with a 1 year time horizon. Children enter the model being stable on methylphenidate, and can either remain on methylphenidate or add behavioural therapy. As the model is using a time horizon of 12 months and the trial data is also 12 months long – no assumptions need to be made beyond 12 months about what patients might then go on to.</p></div><div id="ch6.s1.6.4.2.2"><h5>Data</h5><p>As mentioned above clinical data is based on a single study.<a class="bk_pop" href="#ch6.r9"><sup>9</sup></a> The only costs included in the model are the costs of the behavioural therapy, as any other costs are assumed to be common to the both arms. Utilities are also from the same source as the other models, with additional sources being tested in a sensitivity analysis. The utility gain from response is assumed to increase linearly over the trial period to reflect that the effect may not be immediate. The response probabilities are derived from analysis in Winbugs software which gave simulations of baseline and treatment response probabilities to use in the PSA.</p></div><div id="ch6.s1.6.4.2.3"><h5>Results</h5><p>The probabilistic base case results showed the ICER of the intervention to be very high (£114,803). The additional benefit from the intervention cannot justify the additional cost of providing the intervention. It is a resource intensive intervention on top of medication because staff time spent on the phone is needed which means the intervention is provided on an individual basis.</p><p>A threshold analysis on costs showed that the cost of the intervention would have to be around 17% what it is in the base case to make the intervention cost effective, which is a significant reduction. This would equate to somewhere between two to three 30 minute phone calls. A threshold analysis on QALYs showed that the incremental QALY would need to go from 0.0076 to 0.0434 to make the intervention cost effective. Varying the time horizon found that the effect would have to be stable after the intervention ended up to at least 3 years to make the intervention cost effective. When varying both the time horizon and the utility gain simultaneously, this also showed that around 3.5 years at minimum (regardless of changes in utility gain) would be needed for the ICER to be under £20,000 per QALY. A 2-way sensitivity analysis varying both the baseline response probability and the intervention response relative risk showed that there is not any level of combination of baseline risk and relative risk that would make the intervention cost effective. Varying the utility values using different sources also showed that the model was sensitive to QALYs but the ICERs still remained high.</p><p>When assuming the effect increases linearly to 6 months (as the phone calls are more intense up until that point), and stays at that level until 12 months, as opposed to increasing linearly to 12 months; This showed that although the ICER fell, it was still above the NICE threshold because although there is a higher incremental QALY, this is still not high enough to justify the cost.</p><p>The results have to be interpreted with caution, because the model is only comparing the addition of a self-help non-pharmacological intervention on top of what was used as a baseline in the study (on MPH). It does not tell us about what else might be cost effective that a patient could add or switch to if they are a partial responder, only that what we have investigated as an addition is not cost effective. It also needs to be interpreted with caution as to whether the results can be extrapolated to other treatments that patients might only be partially responding to. But given the 2-way sensitivity analysis, we can be fairly confident that even another treatment with a higher baseline response rate or higher relative risk wold still not improve the ICER to a level considered cost effective.</p><p>This model is not without its limitations. It is only based on a single study. It can be difficult to also marry-up the conclusions of the model with what might be interpreted from the clinical review about the interventions in question. On a continuous scale, the improvements may be more subtle and there could still be an improvement in quality of life even if someone hasn’t gone from non-response to response. For the study this model is based on (Dose 2016), the clinical review did not find the intervention clinically effective based on continuous outcomes (using the guideline cut-off of >20% of the control group risk). However, using the clinical review MID for dichotomous outcomes implies that the intervention has clinical benefit. Therefore the two outcomes are in conflict here. The committee opinion was that the clinical review in general is unlikely to have captured all the benefits of non-pharmacolgical treatment, because these are wider than just ADHD core symptoms. Other benefits also may not have been captured such as longer term impacts which are unknown, and the impact on other sectors. Structural assumptions keeping the model simple are also a limitation.</p></div></div><div id="ch6.s1.6.4.3"><h5>3. Medication + CBT model</h5><div id="ch6.s1.6.4.3.1"><h5>Model overview</h5><p>This model is comparing staying on medication if you are a partial responder versus adding (individual) CBT. The model is therefore interested in the added value of CBT on top of medication. The population are adolescents who are on a stable dose of medication for the last 2 months (medication is stated as an FDA approved medication for ADHD), but have clinically significant symptoms as rated by a CGI-S rating of 3 or above.</p><p>The intervention involved 12 sessions of individual CBT, and two additional parent only sessions were offered.</p><p>A with the previous models, the model is a decision tree model with a 1 year time horizon. Patients who enter the model are already on medication but have some clinically significant symptoms. Patients can either stay on their medication or add CBT on top of their medication. Outcomes are in terms of response or no response at the 4 month time-point because that was the length of the trial.</p></div><div id="ch6.s1.6.4.3.2"><h5>Data</h5><p>This is based on a single study reporting outcomes at 4 months.<a class="bk_pop" href="#ch6.r55"><sup>55</sup></a></p><p>The effect is extrapolated from 4 months to the end of the model (12 months). As the medication the adolescents are currently on is assumed to be the baseline or current practice, then this applies for the whole time horizon of the model. Everyone in the baseline arm of the model stays on the baseline for the whole time period regardless of whether they respond or not. It was decided to extrapolate the effects from the trial and not make further assumptions about what treatments people might go on to following the end of the trial period, as this would involve too many assumptions. It was felt that this would be a larger omission from a model that compared a drug to a non-drug comparison directly (like the ATX model), whereas here we are interested in the addition of an intervention to a common baseline. Because of the baseline applying to both arms it may also be argued that costs are likely to be similar for both arms even if people change treatments over time – unless they change to different treatments or at different times because of the intervention itself, but we had no information on this.</p><p>The response probabilities are derived from analysis in Winbugs software which gave simulations of baseline and treatment response probabilities to use in the PSA.</p><p>The only costs included in the model are the costs of CBT. The source for utility data is the same as has been used in all the models in this guideline. The utility gain from response is assumed to increase linearly over the trial period to reflect that the effect may not be immediate.</p></div><div id="ch6.s1.6.4.3.3"><h5>Results</h5><p>The probabilistic base case results show that the addition of CBT is not cost effective (ICER of £62,007 per QALY). This is mostly down to the high cost of the intervention per person because it is individual rather than group format.</p><p>Various sensitivity analyses were conducted; one sensitivity analysis assumed that the effect of CBT diminishes and linearly decreases down from 4 months when the intervention ends to 12 months. This showed that the ICER increased to £105,192 per QALY because the incremental QALYs fell.</p><p>Threshold analyses showed that the number of sessions that would need to be provided to make the intervention cost effective would be between 3 and 4 – assuming the same level of effect. The incremental QALY between the intervention and comparison would need to be 0.0582 (base case 0.0188) to make the intervention cost effective. The time horizon of the model would also have to be almost 3 years to make the intervention cost effective, all other things being equal, again assuming the effect post treatment is maintained.</p><p>A 2-way sensitivity analysis varying both the baseline response probability and the intervention response relative risk showed that there is not any level of combination of baseline risk and relative risk that would make the intervention cost effective (assuming all other things the same like the base case cost). A 2-way sensitivity analysis varying both the time horizon of the model and the utility gain of responders over non-responders showed that the intervention is cost effective with a shorter time horizon if the incremental utility gain is higher, as expected. Please see Appendix 2 for more details. Finally, varying the utility values using different sources also showed that the model was sensitive to QALYs but the ICERs still remained high.</p><p>The model needs to be interpreted with caution because it can only be inferred that the addition of individual CBT is not cost effective compared to staying on something that you are only partially responding to. It is not providing any information on what other treatments might be more cost effective. There are likely to be other treatments that are more cost effective than adding CBT.</p><p>Limitations include (which are very similar to those of the previous model); the model is only based on a single study with a small population. There is somewhat of a discord between the data that the models use and the data that the clinical review extracted. As mentioned in the limitations section of the previous model – it may be that the improvements on a continuous scale may be more subtle and there could still be an improvement in quality of life even if someone hasn’t gone from non-response to response. From the clinical review using continuous outcomes; the study used in this model showed that the addition of individual CBT to mixed medication has a clinically important benefit. This agrees with the dichotomous outcome. Even though the two outcome types agree, it still remains that even though an intervention might be effective it isn’t effective enough to make it cost effective. The committee opinion was that the clinical review in general is unlikely to have captured all the benefits of non-pharmacolgical treatment, because these are wider than just ADHD core symptoms. Other benefits also may not have been captured such as longer term impacts which are unknown, and the iimpact on other sectors. The structural assumptions the model has made about not including assumptions about further treatment can be seen as a limitation if in fact the addition of CBT has an impact on underlying resource use.</p><p>See <a class="figpopup" href="/books/NBK578099/table/ch6.tab36/?report=objectonly" target="object" rid-figpopup="figch6tab36" rid-ob="figobch6tab36">Table 36</a>, <a class="figpopup" href="/books/NBK578099/table/ch6.tab37/?report=objectonly" target="object" rid-figpopup="figch6tab37" rid-ob="figobch6tab37">Table 37</a> and <a class="figpopup" href="/books/NBK578099/table/ch6.tab38/?report=objectonly" target="object" rid-figpopup="figch6tab38" rid-ob="figobch6tab38">Table 38</a> for summaries of all three models.</p></div></div></div><div id="ch6.s1.6.5"><h4>1.6.5. Unit costs</h4><div id="ch6.s1.6.5.1"><h5>Drug costs</h5><p>Relevant unit costs are provided below to aid consideration of cost-effectiveness. The drugs listed below are based on those identified from the clinical review as well as those commonly used even if the review did not find evidence on them, and therefore do not include the entire list of interventions from the protocol.</p><p>The costs below are illustrative. For the commonly used ADHD drugs; a low and high dose has been demonstrated and taken from the BNF. Some doses were not taken from the BNF and the reason for this is highlighted. Advice has also been taken from the BNF about whether a single dose per day or the doses can be divided, where available. For drugs that are not used for ADHD then the clinical review was used for dosing information.</p><p>Note that there can be various branded generic versions of a drug, but drugs of the same class with the same dose have the same cost in the drug tariff regardless of who manufactures it.</p><p>The pricing structure of the different drugs can also impact the overall cost, as if you are taking a higher dose and you could do this once a day, then a higher dose tablet tends to be cheaper than taking two tablets of half the dose. So with most drugs there are economies of scale of the higher formulations. This isn’t always the case though. With some drugs it is possible to take only one tablet a day, such as the modified release versions, but with others you would need to take tablets at multiple points in the day, which means more pills per day of lower formulations.</p><p>Costs of other healthcare resource such as hospital appointments that may differ by intervention are illustrated below.</p></div><div id="ch6.s1.6.5.2"><h5>Other resource use</h5><p>For example, people on stimulants may see healthcare professionals more frequently in the beginning in order to make sure the dose is appropriate and then may see healthcare professionals less frequently.</p></div><div id="ch6.s1.6.5.3"><h5>Non pharmacological treatment costs</h5><p>Highlighted below are some costs associated with non-pharmacological treatment. <a class="figpopup" href="/books/NBK578099/table/ch6.tab41/?report=objectonly" target="object" rid-figpopup="figch6tab41" rid-ob="figobch6tab41">Table 41</a> shows the costs of individual staff that may be providing treatment such as behavioural therapy/cognitive behavioural therapy</p><p>Costs can vary depending on the band of person providing the treatment. It is also common for the clinician to have an assistant to help with the administration and setting up of the training. The relevant bands for the respective roles were derived from the guideline committee when identifying the inputs for the parent training model.</p><p>The total costs of a course of treatment per person depend upon the number of sessions, whether it is a group or individual course, how much preparation is needed, the band of staff involved, and also the individual components that might make up the course (e.g. if training is also provided for family members/teachers (if children)).</p></div><div id="ch6.s1.6.5.4"><h5>Published costs</h5><p>Some illustrations of specific costs of behavioural therapy training are provided below from the PSSRU;</p></div></div></div><div id="ch6.s1.7"><h3>1.7. Resource impact</h3><p>We do not expect recommendations resulting from this review area to have a significant impact on resources.</p></div><div id="ch6.s1.8"><h3>1.8. Evidence statements</h3><div id="ch6.s1.8.1"><h4>1.8.1. Clinical evidence statements</h4><div id="ch6.s1.8.1.1"><h5>Children and young people aged 5 to 18</h5><div id="ch6.s1.8.1.1.1"><h5>Atomoxetine versus PT/FT</h5><ul id="ch6.l7"><li id="ch6.lt29" class="half_rhythm"><div>No evidence for quality of life, clinical global impression scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt30" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT parent rated; 1 study very low quality) and clinical global impressions scale (PT; 1 study very low quality).</div></li><li id="ch6.lt31" class="half_rhythm"><div>There was no clinically important benefit for ADHD symptoms total (PT parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality), ADHD hyperactivity symptoms (PT teacher rated; 1 study very low quality) and ADHD inattention symptoms (PT parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.1.2"><h5>Stimulants versus Exercise</h5><ul id="ch6.l8"><li id="ch6.lt32" class="half_rhythm"><div>No evidence for quality of life, ADHD symptoms total, clinical global impression scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt33" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT parent rated; 1 study low quality) (PT teacher rated; 1 study low quality) and ADHD inattention symptoms (PT parent rated; 1 study low quality) (PT teacher rated; 1 study moderate quality).</div></li></ul></div><div id="ch6.s1.8.1.1.3"><h5>Stimulants versus NF</h5><ul id="ch6.l9"><li id="ch6.lt34" class="half_rhythm"><div>No evidence for quality of life, clinical global impression scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures and emotional dysregulation.</div></li><li id="ch6.lt35" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT parent rated; 1 study low quality) (PT teacher rated; 1 study low quality) and ADHD inattention symptoms (PT parent rated; 1 study low quality) (PT teacher rated; 1 study low quality).</div></li><li id="ch6.lt36" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality) (FU teacher rated; 1 study very low quality), ADHD hyperactivity symptoms (PT teacher rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (PT self-rated; 2 studies very low quality) (FU self-rated; 1 study very low quality), ADHD inattention symptoms (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (FU teacher rated; 1 study very low quality) (PT self-rated; 1 study very low quality) (FU self-rated; 1 study very low quality) and academic performance (PT self-rated; 1 study very low quality) (FU self-rated; 1 study very low quality).</div></li><li id="ch6.lt37" class="half_rhythm"><div>There was a clinically important harm for ADHD hyperactivity symptoms (PT parent rated; 1 study very low quality) (FU teacher rated; 1 study very low quality), ADHD inattention symptoms (PT teacher rated; 1 study very low quality) (PT self-rated; 1 study very low quality) and academic performance (PT self-rated; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.1.4"><h5>Stimulants + NSST versus stimulants</h5><ul id="ch6.l10"><li id="ch6.lt38" class="half_rhythm"><div>No evidence for quality of life, ADHD symptoms total, ADHD inattention symptoms, clinical global impression scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt39" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT teacher rated; 1 study very low quality) (FU teacher rated; 1 study very low quality).</div></li><li id="ch6.lt40" class="half_rhythm"><div>There were no clinically important benefits for ADHD hyperactivity symptoms (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.1.5"><h5>Mixed medication versus PT/FT</h5><ul id="ch6.l11"><li id="ch6.lt41" class="half_rhythm"><div>No evidence for quality of life, clinical global impression scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures and emotional dysregulation.</div></li><li id="ch6.lt42" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT teacher rated; 1 study low quality) (PT parent rated; 1 study low quality) (PT observer rated; 1 study low quality) and ADHD inattention symptoms (PT teacher rated; 1 study low quality).</div></li><li id="ch6.lt43" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (FU teacher/parent rated; 1 study moderate quality), ADHD inattention symptoms (PT parent rated; 1 study low quality), numeracy outcomes (PT observer rated; 2 studies very low to moderate quality) and literacy outcomes (PT observer rated; 2 studies very low to moderate quality) (FU observer rated; 1 study moderate quality).</div></li></ul></div></div><div id="ch6.s1.8.1.2"><h5>Combination versus non-pharmacological treatment in children and young people</h5><div id="ch6.s1.8.1.2.1"><h5>Atomoxetine + PT/FT versus PT/FT</h5><ul id="ch6.l12"><li id="ch6.lt44" class="half_rhythm"><div>No evidence for quality of life, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt45" class="half_rhythm"><div>There was a clinically important benefit for ADHD symptoms total (PT teacher rated; 1 study low quality), ADHD hyperactivity symptoms (PT parent rated; 1 study low quality) (PT teacher rated; 1 study low quality), ADHD inattention symptoms (PT teacher rated; 1 study low quality) and clinical global impression scale (PT; 1 study low quality).</div></li><li id="ch6.lt46" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 1 study low quality) and ADHD inattention symptoms (PT parent rated; 1 study low quality).</div></li></ul></div><div id="ch6.s1.8.1.2.2"><h5>Atomoxetine + PE versus PE</h5><ul id="ch6.l13"><li id="ch6.lt47" class="half_rhythm"><div>No evidence for clinical global impression scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures and emotional dysregulation.</div></li><li id="ch6.lt48" class="half_rhythm"><div>There was a clinically important benefit for quality of life (PT parent rated; 1 study moderate quality), ADHD symptoms total (PT parent rated; 1 study high quality), ADHD hyperactivity symptoms (PT parent rated; 1 study high quality), ADHD inattention symptoms (PT parent rated; 1 study high quality) and academic outcomes (PT parent rated; 1 study moderate quality).</div></li></ul></div><div id="ch6.s1.8.1.2.3"><h5>Atomoxetine + CBT versus CBT</h5><ul id="ch6.l14"><li id="ch6.lt49" class="half_rhythm"><div>No evidence for quality of life, ADHD hyperactivity symptoms, ADHD inattention symptoms, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt50" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT self-rated; 1 study low quality).</div></li><li id="ch6.lt51" class="half_rhythm"><div>There was a clinically important harm for ADHD symptoms total (PT parent rated; 1 study low quality) and clinical global impressions scale (PT; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.2.4"><h5>Stimulants + NF versus NF</h5><ul id="ch6.l15"><li id="ch6.lt52" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures and emotional dysregulation.</div></li><li id="ch6.lt53" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT self-rated; 1 study very low quality), ADHD inattention symptoms (FU teacher rated; 1 study very low quality) and academic outcomes (PT self-rated; 1 studies very low quality).</div></li><li id="ch6.lt54" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality) (FU teacher rated; 1 study very low quality), ADHD hyperactivity symptoms (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality) (FU teacher rated; 1 study very low quality) (FU self-rated; 1 study very low quality), ADHD inattention symptoms (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (PT self-rated; 1 study very low quality) (FU self-rated; 1 study very low quality) and academic outcomes (FU self-rated; 1 study low quality).</div></li><li id="ch6.lt55" class="half_rhythm"><div>There was a clinically important harm for ADHD hyperactivity symptoms (PT self-rated; 1 study very low quality), ADHD inattention symptoms (PT teacher rated; 1 study very low quality) (PT self-rated; 1 study very low quality) and academic outcomes (PT self-rated; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.2.5"><h5>Stimulants + CBT versus CBT</h5><ul id="ch6.l16"><li id="ch6.lt56" class="half_rhythm"><div>No evidence for quality of life, ADHD hyperactivity symptoms, ADHD inattention symptoms, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt57" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT observer rated; 1 study high quality).</div></li></ul></div><div id="ch6.s1.8.1.2.6"><h5>Mixed medication + PT/FT versus PT/FT</h5><ul id="ch6.l17"><li id="ch6.lt58" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures and emotional dysregulation.</div></li><li id="ch6.lt59" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT teacher rated; 1 study low quality) (PT observer rate; 1 study low quality) and ADHD inattention symptoms (PT parent rated; 1 study low quality) (PT teacher rated; 1 study low quality).</div></li><li id="ch6.lt60" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (FU teacher/parent rated; 1 study moderate quality), numeracy outcomes (PT observer rated ; 2 studies very low to low quality), literacy outcomes (PT observer rated; 2 studies very low to moderate quality) (FU observer rated; 1 study moderate quality).</div></li><li id="ch6.lt61" class="half_rhythm"><div>There was a clinically important harm for ADHD hyperactivity symptoms (PT parent rated; 1 study moderate quality).</div></li></ul></div></div><div id="ch6.s1.8.1.3"><h5>Combination versus pharmacological treatment in children and young people</h5><div id="ch6.s1.8.1.3.1"><h5>Atomoxetine + PT/FT versus atomoxetine</h5><ul id="ch6.l18"><li id="ch6.lt62" class="half_rhythm"><div>No evidence for quality of life, discontinuation due to side effects, serious adverse events, minor adverse events, emotional dysregulation, numeracy outcomes and literacy outcomes.</div></li><li id="ch6.lt63" class="half_rhythm"><div>There was a clinically important benefit for ADHD symptoms total (PT teacher rated; 1 study very low quality).</div></li><li id="ch6.lt64" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 1 study very low quality), ADHD hyperactivity symptoms (PT parent rated; 2 studies very low quality) (PT teacher rated; 2 studies very low quality), ADHD inattention symptoms (PT parent rated; 2 studies very low quality) (PT teacher rated; 2 studies very low quality), clinical global impression scale (PT; 2 studies very low quality) and behaviour outcomes (PT teacher rated; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.2"><h5>Stimulants + PT/FT versus stimulants</h5><ul id="ch6.l19"><li id="ch6.lt65" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, emotional dysregulation, numeracy outcomes and literacy outcomes.</div></li><li id="ch6.lt66" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT teacher rated; 1 study very low quality).</div></li><li id="ch6.lt67" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 3 studies low quality) (FU parent rated; 1 study low quality) (PT teacher rated; 2 1 study low quality), ADHD hyperactivity symptoms (PT parent rated; 2 studies moderate quality) (FU parent rated; 1 study very low quality) (FU teacher rated; 1 study very low quality), ADHD inattention symptoms (PT parent rated; 1 study low quality) and behavioural outcomes (PT parent rated; 1 study low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.3"><h5>Stimulants + PT/FT versus stimulants + NSST</h5><ul id="ch6.l20"><li id="ch6.lt68" class="half_rhythm"><div>No evidence for quality of life, ADHD symptoms total, ADHD inattention symptoms, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt69" class="half_rhythm"><div>There were no clinically important benefits for ADHD hyperactivity symptoms (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (PT teacher rated; 1 study low quality).</div></li><li id="ch6.lt70" class="half_rhythm"><div>There was a clinically important harm for ADHD hyperactivity symptoms (FU teacher rated; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.4"><h5>Stimulants + attention/memory/cognitive training versus stimulants</h5><ul id="ch6.l21"><li id="ch6.lt71" class="half_rhythm"><div>No evidence for quality of life, ADHD hyperactivity symptoms, ADHD inattention symptoms, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt72" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 1 study low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.5"><h5>Stimulants + NF versus stimulants</h5><ul id="ch6.l22"><li id="ch6.lt73" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures and emotional dysregulation.</div></li><li id="ch6.lt74" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT parent rated; 1 study very low quality), (PT teacher rated; 1 study very low quality).</div></li><li id="ch6.lt75" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality) (FU teacher rated; 1 study very low quality), ADHD hyperactivity symptoms (FU parent rated; 1 study very low quality) (FU teacher rated; 1 study very low quality) (PT self-rated; 1 study very low quality) (FU self-rated; 1 study very low quality), ADHD inattention symptoms (PT parent rated; 1 study very low quality) (FU parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality) (FU teacher rated; 1 study very low quality) (PT self-rated; 2 studies very low quality) (FU self-rated; 1 study very low quality) and academic outcomes (PT self-rated; 1 study very low quality) (FU self-rated; 1 study very low quality).</div></li><li id="ch6.lt76" class="half_rhythm"><div>There was a clinically important harm for ADHD hyperactivity symptoms (PT self-rated; 1 study very low quality) and academic outcomes (PT self-rated; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.6"><h5>Mixed medication + PT/FT versus mixed medication</h5><ul id="ch6.l23"><li id="ch6.lt77" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events and minor adverse events.</div></li><li id="ch6.lt78" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (FU parent rated; 1 study very low quality) (FU teacher/parent rated; 1 study moderate quality), ADHD hyperactivity symptoms (PT teacher rated; 3 studies very low to moderate quality) (FU parent rated; 1 study low quality), ADHD inattention symptoms (PT parent rated; 1 study moderate quality) (PT teacher rated; 1 study moderate quality) (FU parent rated; 1 study very low quality), behavioural outcomes (PT teacher rated; 2 studies very low quality), emotional dysregulation (PT teacher rated; 1 study very low quality), numeracy outcomes (PT; 2 studies very low to moderate quality), literacy outcomes (PT; 2 studies very low to moderate quality) (FU; 1 study moderate quality) and academic outcomes (PT teacher rated; 2 studies very low quality).</div></li><li id="ch6.lt79" class="half_rhythm"><div>There was a clinically important harm for ADHD hyperactivity symptoms (PT parent rated; 1 study moderate quality) (PT observer rated; 1 study low quality) and emotional dysregulation (PT teacher rated; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.7"><h5>Mixed medication + CBT versus mixed medication</h5><ul id="ch6.l24"><li id="ch6.lt80" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt81" class="half_rhythm"><div>There was a clinically important benefit for ADHD symptoms total (PT self-rated; 2 studies low to moderate quality) (PT parent rated; 2 studies low to moderate quality), ADHD hyperactivity symptoms (PT self-rated; 1 study low quality) (PT parent rated; 1 study low quality) and ADHD inattention symptoms (PT self-rated; 1 study low quality) (PT parent rated; 1 study low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.8"><h5>Mixed medication + PE versus mixed medication + NSST</h5><ul id="ch6.l25"><li id="ch6.lt82" class="half_rhythm"><div>No evidence for quality of life, ADHD symptoms total, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse event and literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt83" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT parent rated; 1 study low quality) and ADHD inattention symptoms (PT parent rated; 1 study low quality) (FU parent rated; 1 study low quality).</div></li><li id="ch6.lt84" class="half_rhythm"><div>There were no clinically important benefits for ADHD hyperactivity symptoms (FU parent rated; 1 study low quality), behavioural outcomes (PT parent rated; 1 study low quality) (FU parent rated; 1 study low quality) and emotional dysregulation (PT parent rated; 1 study moderate quality) (FU parent rated; 1 study low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.9"><h5>Mixed medication + sleep intervention versus mixed medication</h5><ul id="ch6.l26"><li id="ch6.lt85" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt86" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 2 studies very low quality) (PT teacher rated; 2 studies low quality), ADHD hyperactivity symptoms (PT teacher rated; 2 studies very low to low quality) (PT parent rated; 2 studies very low quality), ADHD inattention symptoms (PT parent rated; 2 studies very low quality) (PT teacher rated; 2 studies low quality) and behavioural outcomes (PT teacher rated; 2 studies very low to low quality).</div></li></ul></div><div id="ch6.s1.8.1.3.10"><h5>Mixed medication + NF versus mixed medication</h5><ul id="ch6.l27"><li id="ch6.lt87" class="half_rhythm"><div>No evidence for quality of life, ADHD hyperactivity symptoms, ADHD inattention symptoms, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt88" class="half_rhythm"><div>There was a clinically important benefit for ADHD symptoms total (PT teacher rated; 1 study low quality) and behavioural outcomes (PT parent rated; 1 study low quality).</div></li></ul></div></div><div id="ch6.s1.8.1.4"><h5>Combination versus no treatment/usual care in children and young people</h5><div id="ch6.s1.8.1.4.1"><h5>Atomoxetine + PT/FT versus placebo/usual care</h5><ul id="ch6.l28"><li id="ch6.lt89" class="half_rhythm"><div>No evidence for quality of life, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt90" class="half_rhythm"><div>There was a clinically important benefit for ADHD symptoms total (PT parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality), ADHD hyperactivity symptoms (PT parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality), ADHD inattention symptoms (PT parent rated; 1 study very low quality) (PT teacher rated; 1 study very low quality) and clinical global impressions scale (PT; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.4.2"><h5>Mixed medication + PT/FT versus placebo/usual care</h5><ul id="ch6.l29"><li id="ch6.lt91" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures and emotional dysregulation.</div></li><li id="ch6.lt92" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT teacher rated; 1 study low quality) and ADHD inattention symptoms (PT parent rated; 1 study low quality) (PT teacher rated; 1 study low quality).</div></li><li id="ch6.lt93" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT teacher/parent rated; 1 study moderate quality), ADHD hyperactivity symptoms (PT observer rated; 1 study moderate quality), numeracy outcomes (PT observer rated; 2 studies very low to moderate quality) and literacy outcomes (PT observer rated; 2 studies very low to low quality) (FU observer rated; 1 study moderate quality).</div></li><li id="ch6.lt94" class="half_rhythm"><div>There was a clinically important harm for ADHD hyperactivity symptoms (PT parent rated; 1 study low quality).</div></li></ul></div></div><div id="ch6.s1.8.1.5"><h5>Combination versus other combined treatments in children and young people</h5><div id="ch6.s1.8.1.5.1"><h5>Stimulants + NF versus stimulants + attention/memory/cognitive training</h5><ul id="ch6.l30"><li id="ch6.lt95" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, emotional dysregulation, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt96" class="half_rhythm"><div>There was a clinically important benefit for ADHD inattention symptoms (FU teacher rated; 1 study high quality).</div></li><li id="ch6.lt97" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT parent rated; 1 study moderate quality) (PT teacher rated; 1 study moderate quality) (FU parent rated; 1 study moderate quality) (FU teacher rated; 1 study moderate quality), ADHD hyperactivity symptoms (PT parent rated; 1 study moderate quality) (PT teacher rated; 1 study moderate quality) (FU parent rated; 1 study moderate quality) (FU teacher rated; 1 study moderate quality) and ADHD inattention symptoms (PT parent rated; 1 study moderate quality) (PT teacher rated; 1 study moderate quality) (FU parent rated; 1 study moderate quality).</div></li></ul></div></div><div id="ch6.s1.8.1.6"><h5>Adults over the age of 18</h5><div id="ch6.s1.8.1.6.1"><h5>Pharmacological treatment versus non-pharmacological treatment in adults</h5><div id="ch6.s1.8.1.6.1.1"><h5>Stimulants + NSST versus CBT</h5><ul id="ch6.l31"><li id="ch6.lt98" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt99" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT self-rated; 1 study low quality) (PT observer rated; 1 study low quality), ADHD hyperactivity symptoms (PT observer rated; 1 study low quality), ADHD inattention symptoms (PT observer rated; 1 study moderate quality) and emotional dysregulation (PT self-rated; 1 study moderate quality).</div></li></ul></div></div><div id="ch6.s1.8.1.6.2"><h5>Combination versus non-pharmacological treatment in adults</h5><div id="ch6.s1.8.1.6.2.1"><h5>Stimulants + CBT/DBT versus CBT/DBT alone</h5><ul id="ch6.l32"><li id="ch6.lt100" class="half_rhythm"><div>No evidence for quality of life, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt101" class="half_rhythm"><div>There was a clinically important benefit for ADHD symptoms total (PT self-rated; 1 study low quality) (PT observer rated; 1 study moderate quality) and clinical global impressions scale (FU; 1 study high quality).</div></li><li id="ch6.lt102" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT self-rated; 1 study low quality) (PT observer rated; 2 studies low quality), ADHD hyperactivity symptoms (PT observer rated; 1 study low quality), ADHD inattention symptoms (PT observer rated; 1 study low quality), emotional dysregulation (PT; 2 studies moderate quality) and clinical global impressions scale (PT; 1 study low quality).</div></li><li id="ch6.lt103" class="half_rhythm"><div>There was a clinically important harm for ADHD symptoms total (PT self-rated; 1 study low quality).</div></li></ul></div><div id="ch6.s1.8.1.6.2.2"><h5>Stimulants + CBT/DBT + PT/FT versus NSST + PT/FT alone</h5><ul id="ch6.l33"><li id="ch6.lt104" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt105" class="half_rhythm"><div>There was a clinically important benefit for ADHD hyperactivity symptoms (PT observer rated; 1 study low quality).</div></li><li id="ch6.lt106" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT observer rated; 1 study low quality), ADHD inattention symptoms (PT observer rated; 1 study low quality), child ADHD symptoms total (PT parent rated; 1 study low quality) and emotional dysregulation (PT parent rated; 1 study moderate quality).</div></li></ul></div></div><div id="ch6.s1.8.1.6.3"><h5>Combination versus pharmacological treatment in adults</h5><div id="ch6.s1.8.1.6.3.1"><h5>Stimulants + CBT/DBT versus stimulants + NSST alone</h5><ul id="ch6.l34"><li id="ch6.lt107" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt108" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT self-rated; 1 study moderate quality) (PT observer rated; 1 study moderate quality), ADHD hyperactivity symptoms (PT observer rated; 1 study moderate quality), ADHD inattention symptoms (PT observer rated; 1 study moderate quality) and emotional dysregulation (PT; self-rated 1 study moderate quality).</div></li></ul></div><div id="ch6.s1.8.1.6.3.2"><h5>Mixed medication + CBT/DBT versus mixed medication alone</h5><ul id="ch6.l35"><li id="ch6.lt109" class="half_rhythm"><div>No evidence for discontinuation due to side effects, serious adverse events, minor adverse events, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt110" class="half_rhythm"><div>There was a clinically important benefit for ADHD symptoms total (PT observer rated; 1 study low quality) (PT self-rated; 3 studies very low quality) (FU self-rated; 2 studies very low quality), ADHD hyperactivity symptoms (FU self-rated; 2 studies very low quality), ADHD inattention symptoms (PT self-rated; 2 studies very low quality)(FU self-rated; 2 studies very low quality), clinical global impressions scale (PT; 1 study low quality), emotional dysregulation (PT observer rated; 1 study low quality) (PT self-rated; 1 study very low quality) (FU self-rated; 1 study low quality) and behavioural outcomes (FU; 1 study very low quality).</div></li><li id="ch6.lt111" class="half_rhythm"><div>There were no clinically important benefits for quality of life (PT; 1 study very low quality) (FU; 1 study very low quality), ADHD hyperactivity symptoms (PT self-rated; 2 studies very low quality) and behavioural outcomes (PT; 1 study very low quality).</div></li></ul></div><div id="ch6.s1.8.1.6.3.3"><h5>Mixed medication + CBT/DBT versus mixed medication + NSST</h5><ul id="ch6.l36"><li id="ch6.lt112" class="half_rhythm"><div>No evidence for discontinuation due to side effects, serious adverse events, minor adverse events, behavioural outcomes, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt113" class="half_rhythm"><div>There was a clinically important benefit for clinical global impressions scale (PT; 1 study very low quality).</div></li><li id="ch6.lt114" class="half_rhythm"><div>There were no clinically important benefits for quality of life (PT; 1 study low quality), ADHD symptoms total (PT self-rated 2 studies very low quality) (FU self-rated 1 study very low quality), ADHD hyperactivity symptoms (PT self-rated; 1 study very low quality), ADHD inattention symptoms (PT self-rated; 1 study very low quality) and emotional dysregulation (PT self-rated; 1 study very low quality).</div></li></ul></div></div><div id="ch6.s1.8.1.6.4"><h5>Combination versus no treatment/usual care in adults</h5><div id="ch6.s1.8.1.6.4.1"><h5>Stimulants + CBT/DBT compared to NSST alone</h5><ul id="ch6.l37"><li id="ch6.lt115" class="half_rhythm"><div>No evidence for quality of life, clinical global impressions scale, discontinuation due to side effects, serious adverse events, minor adverse events, behavioural measures, literacy outcomes and numeracy outcomes.</div></li><li id="ch6.lt116" class="half_rhythm"><div>There were no clinically important benefits for ADHD symptoms total (PT self-rated; 1 study low quality) (PT observer rated; 1 study low quality), ADHD hyperactivity symptoms (PT observer rated; 1 study low quality), ADHD inattention symptoms (PT observer rated; 1 study low quality) and emotional dysregulation (PT self-rated; 1 study moderate quality).</div></li></ul></div></div></div></div><div id="ch6.s1.8.2"><h4>1.8.2. Health economic evidence statements</h4><div id="ch6.s1.8.2.1"><h5>CG72 evidence</h5><ul id="ch6.l38"><li id="ch6.lt117" class="half_rhythm"><div>One cost-utility analysis found that medication + individual CBT was not cost effective compared to medication alone, for treating ADHD in adults on medication but with clinically significant symptoms (ICER: £65,279). This analysis was assessed as directly applicable with potentially serious limitations.</div></li></ul></div><div id="ch6.s1.8.2.2"><h5>Update guideline evidence</h5><ul id="ch6.l39"><li id="ch6.lt118" class="half_rhythm"><div>One original cost-utility analysis found that behavioural therapy was cost effective (had the highest net benefit) compared to atomoxetine, and a combination of behavioural therapy and atomoxetine, for treating ADHD in children. This analysis was assessed as directly applicable with potentially serious limitations.</div></li><li id="ch6.lt119" class="half_rhythm"><div>One original cost-utility analysis found that Methylphenidate + self-help behavioural therapy was not cost effective compared to methylphenidate alone, for treating ADHD in children on methylphenidate but with functional impairment (ICER: £114,803). This analysis was assessed as directly applicable with potentially serious limitations.</div></li><li id="ch6.lt120" class="half_rhythm"><div>One original cost-utility analysis found that medication + individual CBT was not cost effective compared to medication alone, for treating ADHD in adolescents on medication but with clinically significant symptoms (ICER: £62,007). This analysis was assessed as directly applicable with potentially serious limitations.</div></li></ul></div></div></div><div id="ch6.s1.9"><h3>1.9. The committee’s discussion of the evidence</h3><div id="ch6.s1.9.1"><h4>1.9.1. Interpreting the evidence</h4><div id="ch6.s1.9.1.1"><h5>1.9.1.1. The outcomes that matter most</h5><p>The committee considered quality of life, ADHD symptoms and CGI assessment of response to be critical outcomes. ADHD symptoms were separately considered as total, hyperactivity and inattention subscales. The committee did not prioritise any one subscale. ADHD symptoms were separately considered when reported by self, parent, teacher and investigator. The committee considered that all had their merit but that symptoms reported by teacher or investigator were likely to be the most objective assessment of effect.</p><p>The committee considered intervention related discontinuations, serious adverse events, behavioural/functional measures, emotional dysregulation and academic outcomes to be important outcomes.</p></div><div id="ch6.s1.9.1.2"><h5>1.9.1.2. The quality of the evidence</h5><p>The committee noted that the body of evidence for this review was typically low or very low quality. There was no evidence in children under the age of 5 for this review. There was a larger body of evidence for children aged 5 to 18 than for adults over the age of 18. While there were a large number of studies meeting the criteria for the review, in general they were small studies providing imprecise results and only single studies per outcome.</p><p>The overall objective of the review was to compare the broad strategies of pharmacological and non-pharmacological interventions both for ADHD symptoms and behaviour, either in isolation or combination. As the committee agreed that different interventions under the headings of pharmacological and non-pharmacological may well have different effects, as established by the separate specific pharmacological and non-pharmacological reviews, these were kept separate. However it was difficult to determine whether or not conflicting results reported by two or more studies related specifically to the interventions under investigation or other factors that differed between trials (for example the exact previous treatment and response of the participants, the quality and content of usual care).</p><p>The committee noted that behavioural outcomes, on which one might expect non-pharmacological interventions to have a greater impact such as the outcomes focusing on behaviour and emotional dysregulation, were less commonly reported than ADHD symptom outcomes.</p><p>The committee noted that it is much more challenging to provide a true active control arm for non-pharmacological interventions compared with the use of placebo for pharmacological interventions, therefore the trials included in these reviews were rarely if ever blinded to the non-pharmacological intervention allocation.</p><p>The committee acknowledged that these limitations in the design of non-pharmacological treatments could impact on the interpretation of the effectiveness of non-pharmacological treatments.</p><p>The committee agreed that the quality of the evidence in the review was not sufficient to make strong recommendations about specific combinations of any interventions.</p></div><div id="ch6.s1.9.1.3"><h5>1.9.1.3. Benefits and harms</h5><div id="ch6.s1.9.1.3.1"><h5>Overall (and children aged 5 to 18)</h5><p>Overall the committee agreed that the evidence supported the following statements. Direct comparisons of pharmacological treatment with non-pharmacological treatment showed a benefit for pharmacological treatment, principally in terms of ADHD symptoms. Combined treatments showed a benefit in ADHD symptoms over either pharmacological treatment or non-pharmacological treatment in isolation, this benefit was larger and more consistently observed when compared with non-pharmacological treatment, although the benefit did not consistently equate to a clinically important difference as per the committee’s previously agreed thresholds. Combined treatments showed a benefit in ADHD symptoms compared to no active intervention or usual care. No comparison between any two combined treatments showed a clear picture of consistent clinically important benefit. The committee noted that although the above was an appropriate summary of the evidence, there were many comparisons showing no clinical difference and relatively frequent inconsistencies across the evidence base.</p><p>The benefits from the HE modelling were as follows: in the child atomoxetine combination model, total QALYS were as follows; behavioural therapy: 0.773, Atomoxetine: 0.790, combination treatment: 0.794. In the child methylphenidate + self-help behavioural therapy model, total QALYs were 0.7648 in the intervention arm (combination), and 0.7573 in the comparator arm. In the adolescent CBT combination model, total QALYs were 0.7748 in the intervention arm (combination), and 0.7561 in the comparator arm.</p><p>The committee noted that although it was not entirely clear from the evidence base, theoretically non-pharmacological treatments and pharmacological treatments are likely to be effective at targeting different aspects of ADHD. Pharmacological treatments may be better for treating the core symptoms of ADHD whereas non-pharmacological treatments may be more beneficial for improving the functional status of people with ADHD.</p><p>Before considering whether any treatment at all is necessary for ADHD symptoms, the committee recommended that appropriate environmental modifications were in place – in some situations this may be all that is required to address the impact of milder ADHD symptoms.</p><p>The committee noted that any treatment choice for ADHD is associated with potential harms. Drugs are often considered to be ‘more harmful’ (see the pharmacological adverse events review for more detail on specific adverse effects of various drug options), however non-pharmacological treatments may have specific harms of their own (for example for people who feel stigmatised by having to undergo parent training) and if a person’s treatment choice is not optimised to reduce their ADHD symptoms, there is harm from under treatment.</p></div><div id="ch6.s1.9.1.3.2"><h5>Children under the age of 5</h5><p>There was no evidence identified in this review for this population. The committee agreed that the effects seen in children aged 5 to 18 were likely to be similar in the under 5 age group, however the committee noted that concerns around the adverse effects of medication in this younger age group.</p></div><div id="ch6.s1.9.1.3.3"><h5>Adults aged over 18</h5><p>The committee noted that the studies in the combination review and non-pharmacological review in this age group focused heavily on CBT. CBT was specifically recommended in the previous guideline as the non-pharmacological intervention of choice in adults with ADHD. The non-pharmacological review supported the finding that CBT had a benefit for ADHD symptoms when compared with no intervention or usual care. However both reviews showed little difference between CBT and a non-specific supportive therapy. The committee was keen to emphasise that this did not imply a lack of efficacy of CBT and noted that the non-specific supportive therapies typically involved regular periods of face to face counselling. The committee agreed that this suggested that CBT is effective but that for some people, it may be possible to achieve similar benefits with structured programs that do not necessarily adhere to the principles of CBT.</p></div><div id="ch6.s1.9.1.3.4"><h5>Subgroups</h5><p>There was insufficient evidence in this review to inform specific recommendations about subgroups of people with ADHD, either based on the severity of their symptoms or on any co-existing disorders.</p><p>Given the health economic evidence and the previous guideline recommendations, the committee agreed that it was appropriate to make consensus based recommendations on which groups may benefit from a combined approach. In children and young people, the committee supported the recommendations from the NICE guideline on antisocial behaviour and conduct disorders in children and young people, in which the families of all children with or at high risk of developing ODD/CD should be offered group parent training programmes.</p><p>Previous recommendations differentiated between children with mild or moderate ADHD and severe ADHD and suggested different strategies for the two groups. These recommendations were purely consensus based as no evidence existed to support that differentiation. In this update, again no evidence was found to support a differential strategy based on severity. However again the committee’s consensus view was that medication should be reserved for those in whom ADHD was having significant impairment on their life. The committee agreed that as short term adverse effects of medication are well reported compared to other treatment approaches it is difficult to compare harms across treatments, but they are present in people that take medication (as documented in <a href="/books/n/niceng87er4/" class="toc-item">evidence report D</a> on pharmacological safety) and healthcare professionals should only be offering medication to children in whom the risk benefit balance supported this decision. To achieve this aim, the committee recommended that medication should be first line treatment for those in whom environmental modifications had not reduced the impact of ADHD symptoms on at least one area of a child or adults’ everyday life. This categorisation differs from the previous guideline’s use of ‘severe ADHD’ and the committee agreed it was appropriate to focus more on the impact of symptoms as opposed to a diagnostic assessment of severity of disease. Addressing persistent symptoms in one domain is important in this age group, for example, parent/carer training and environmental modification may have reduced impairment in situations and relationships at home but not at school, it is important that the impairment at school is addressed to ensure the child or young person is has the best opportunity to achieve at school.</p><p>The committee noted that much of the evidence in this review on atomoxetine in children came from a study specifically looking at children with ADHD and ASD. Few of the pooled comparisons included this evidence but where this was the case – there was no obvious heterogeneity to support a different treatment effect in this population compared to the general population..</p></div></div></div><div id="ch6.s1.9.2"><h4>1.9.2. Cost effectiveness and resource use</h4><p>No published economic evidence was identified for this question. Four studies included as economic evidence for this question in the previous guideline have been selectively excluded for reasons of applicability and methodological quality.</p><p>The previous guideline conducted two original economic models looking at combination treatments versus individual treatments, one in children and one in adults. The child model has been selectively excluded because it was based on two studies not included in the clinical review, it is however also superseded by three new models on combinations in children. The adult model is included in this update because no new modelling has been undertaken for adults as it was not felt to add value or change the conclusions of the previous model. A summary of the existing adult combination model and new children models can be found below.</p><p>The previous model in adults was in a population of adults with ADHD who are stable on medication but have clinically significant symptoms, and compared adding CBT to medication versus staying on medication alone. It was a decision tree model with a 1 year time horizon based on two short terms trials for clinical effect. This found that the addition of CBT was not cost effective with an ICER of £65,279 per QALY. This analysis was rated as directly applicable with potentially serious limitations, such as only based on two trials, extrapolation of effect, and only included intervention costs.</p><div id="ch6.s1.9.2.1"><h5>New health economic analysis – Atomoxetine combination model</h5><p>The previous child model was updated because it was expected there would be new data in children, and the combination questions have economic implications in terms of the trade-off between two interventions together having a large resource impact weighed up against whether the additional effect is enough to make them cost effective. It was discussed whether the effects of two different types of interventions were expected to be additive, and this was not believed to be the case, therefore even if pharmacological treatment is cost effective compared to doing nothing, and non-pharmacological treatment is cost effective compared to doing nothing; we cannot make the assumption that both together would therefore be cost effective. Only dichotomous outcomes could be used for a model to link to quality of life, which automatically reduces the pool of studies that can be used from the clinical review. The studies that had dichotomous outcomes had comparisons that the committee felt couldn’t be combined, particularly around the differences in behavioural treatments for example it would not be appropriate to combine parent training with CBT. This is why the previous child model is being superseded by 3 models.</p><p>The first child model compared atomoxetine in combination with behavioural therapy (group parent training), to atomoxetine alone and behavioural therapy alone. This was a decision tree model with a one year time horizon. The population was mixed in terms of some children in the trials having treatment before, but none selected people specifically who were previous non-responders (or responders). Patients could withdraw from adverse events of atomoxetine and the model also included tolerable adverse events that had a utility decrement but treatment continued. Resource use of drugs and behavioural therapy were elicited from the committee. Clinical effectiveness was from 3 studies and these were combined in a network meta-analysis for the model. The probabilistic results showed behavioural therapy was the most cost effective. This was the cheapest and also the least effective intervention, but had the highest net benefit because the ICERs (when comparing an intervention to the next cheapest) were above the NICE £20,000 threshold (Atomoxetine compared to behavioural therapy: £44,175 per QALY, and combination treatment compared to Atomoxetine: £56,219 per QALY). Atomoxetine is more costly than behavioural therapy because of the ongoing monitoring required for each child, whereas the cost of behavioural therapy is spread over a group of children and is only for a short time frame. A sensitivity analysis using individual behavioural therapy costs showed that atomoxetine dominated behavioural therapy, and atomoxetine was the most cost effective compared to combination treatment. Another sensitivity analysis made assumptions about the effect of behavioural therapy diminishing after the treatment duration (10 weeks) and going down to zero by the end of the model (whereas in the base case the responders were assumed to remain responders for the whole time horizon), behavioural therapy still had the highest net benefit. Using different sources of utility values that derived utilities in different ways (such as direct valuation of health states, and using another generic measure instead of the EQ-5D) also did not lead to a different result. This was done to reassure the GC about the sensitivity of the EQ-5D, which it was debated is perhaps inappropriate for this condition, but there is no empirical evidence to support this. This analysis was assessed as directly applicable with potentially serious limitations. This is because it is only based on a small number of trials, no assumptions were made about further lines of treatment and so the costs and QALYs may be being underestimated because a non-responder will most likely find other treatments that work for them to accrue QALYs and costs. Also, the committee highlighted that the effectiveness of non-pharmacological treatments is not well captured in trials and may be underestimated.</p></div><div id="ch6.s1.9.2.2"><h5>New health economic analysis – Methylphenidate + self-help telephone BT model</h5><p>The second model compared methylphenidate with the addition of telephone self-help behavioural therapy versus methylphenidate alone, in a population of children who are partial responders to methylphenidate (i.e. from the single clinical study used for effect this is specifically children who are stable on methylphenidate but have some functional impairment). This was a decision tree model with a 1 year time horizon. The clinical study used for effect had 12 month outcomes. No adverse events or costs of methylphenidate were included because this was the baseline common to both arms. Only intervention costs of the behavioural therapy were included. Probabilistic results showed that the addition of the behavioural therapy was highly cost ineffective (ICER = £114,803 per QALY). The incremental cost was high because this is an individual therapy. The incremental QALY was also small because the difference in response probabilities between the comparisons was quite small. Threshold analyses showed that the cost of the intervention would have to be significantly smaller to make the intervention cost effective. See appendix 2 for further detail on other threshold analyses undertaken. A 2-way sensitivity analysis varying the treatment effect and baseline probability showed that no combination of baseline and treatment effect would make the intervention cost effective, all other things being equal. As with the previous model, different utility sources were used, and the effect increased linearly to 6 months and remained at that level (as the phone calls were more intense up to that point) rather than increasing linearly to 12 months. Neither of these sensitivity analyses changed the conclusions. This analysis was assessed as directly applicable with potentially serious limitations. Similarly to the last model; effect is only based on a small sample of data – one study, effect could have been underestimated, and the structure has been kept simple.</p></div><div id="ch6.s1.9.2.3"><h5>New health economic analysis – medication + CBT model</h5><p>The third model compared medication with the addition of individual CBT versus medication alone. This was in a population of adolescents who were stable on medication but had some clinically significant symptoms. This was a decision tree model with a 1 year time horizon. No adverse events or costs of medication were included because this was the baseline common to both arms. Only intervention costs of CBT were included. The effectiveness of the comparisons was informed by a single study with trial duration of 4 months. Probabilistic results showed that the addition of the individual CBT was not cost effective (ICER = £62,007 per QALY) the incremental cost was again high because the intervention is individual and consists of 12 sessions. The cost of the intervention would need to be below around 32% of the base case cost to make the intervention cost effective. This equates to around 3 to 4 sessions or about 6 hours of CBT. The time horizon of the mode would need to be around 3 years to make the intervention cost effective. A 2-way sensitivity analysis of baseline and treatment effect showed that only with a very low baseline risk and very high treatment effect would the intervention be cost effective. If we also assume the effect of the treatment is not maintained the ICER becomes even larger (£105,192 per QALY). This analysis was assessed as directly applicable with potentially serious limitations. As with the previous models; effect is based on a single study, the effect may be being underestimated because trials are not good at capturing wider outcomes that CBT would address, the structure of the model is kept simple and so costs and effects may be being underestimated.</p></div><div id="ch6.s1.9.2.4"><h5>Children under the age of 5</h5><p>See the non-pharmacological review and rationale for more information about recommendations in this age group. As a summary; medication is not recommended for this age group. The age of the children are considered too young to be medicated. A sensitivity analysis of the parent training model using a study in the under 5 group showed parent training to be cost effective in a group. Combinations are also not recommended in this group.</p></div><div id="ch6.s1.9.2.5"><h5>Children and young people aged over 5</h5><p>Taking all the three models for children together, it can be concluded that it is uncertain if combination treatments (meaning combinations of pharma and non-pharma) are cost effective, because of their costs and also uncertainty about their treatment effect. If the behavioural therapy component is provided in a group, then this lowers the cost, which can have an impact on the result (this is more applicable however to parent training than it is to CBT – which is usually individual). However this is highly dependent on the treatment effect. The models need to be interpreted carefully because of the specific populations they are in; i.e. the implication in the second and third model is that a combination is being offered second line as they are partial responders to a drug, and also because they are on different drugs it needs to be taken into consideration with a consensus committee view about the ordering of treatments in the pathway. Additionally there is uncertainty as to whether results might be generalisable to other drugs for example.</p><p>This review was also about non-pharmacological treatments compared to pharmacological treatments. The only information on cost effectiveness available to us here is the comparison of atomoxetine versus behavioural therapy from the atomoxetine model. This showed that if we assume the effect of behavioural therapy continues, then atomoxetine is not cost effective compared to behavioural therapy. The drug price would have to be very small for atomoxetine to be cost effective because the costs of monitoring a drug far outweigh the costs of the behavioural therapy. If the effect is not maintained after the course has ended then atomoxetine becomes closer to being cost effective. But if the behavioural therapy is individual rather than a group then behavioural therapy is dominated by atomoxetine. However we haven’t included the costs of further treatment to see how this impacts the results, because less people respond on behavioural therapy so a higher proportion of that cohort may end up on more expensive treatments later on, and titrating and monitoring the effect of a drug is resource intensive. So there are downstream trade-offs that we haven’t been able to account for. It is accepted that pharmacological treatments tend to be more effective. There is also more data from the clinical review showing that drugs are effective versus placebo. And published cost effectiveness evidence also showed that drugs are cost effective versus no treatment. Therefore drugs were considered first line and are offered to all people in this age group.</p><p>Based on the cost effectiveness evidence showing that combinations are generally not cost effective, the committee did not recommend combinations for everyone (as supported by the atomoxetine model for example). The committee noted that good current practice provided group support for everyone diagnosed with ADHD that provided education about ADHD and provide -social support. Education about the condition was felt to be an important factor that was highlighted in the qualitative support review. The NICE guideline on patient experience highlights that information about your condition is important, and although it may not directly be an intervention and therefore improve health, it has other benefits that may not be captured in a measure like the QALY. The recommendation states that this could be as little as 1 to 2 sessions, and would incur significantly less cost than a full parent training programme.</p><p>It was acknowledged however as part of the review of medication (<a href="/books/n/niceng87/" class="toc-item">recommendation 1.10.1</a>), that when medication has been optimised and there are still troublesome symptoms impacting on a person’s everyday life the needs of the patient should be further explored.</p><p>The results of the 1 year time horizon model on CBT (and also the telephone support model which was also about individualised treatment), that used a subset of clinical data, showed combinations not to be cost effective. However the committee were concerned that the clinical review (not just the model data) was not capturing the full effects of non-pharmacological treatment. The committee agreed that the effectiveness of non-pharmacological treatments on the condition is not well captured in trials. A more global function measure would be required to capture the impact on factors like self esteem, organisation, relationships, coping with ADHD and in general these more wider factors than just purely symptoms of hyperactivity and inattentiveness. Ideally quality of life or also perhaps the Clinical Global Impressions scales (CGI) are more global, but these were not as prominent in the review data as other outcomes that were more ADHD symptoms based.</p><p>The committee agreed it is likely there are benefits from behavioural therapies that are not being captured in the model. If t these were measurable and captured this would lead to more responders which would mean more people to accrue a higher quality of life in the model. It was the opinion of the committee therefore that particularly in adolescents, CBT in addition to medication that has been optimised would be effective at targeting those residual symptoms and this is good current practice. Hence despite the models’ conclusions the committee were uncertain about the results and made a recommendation based on their clinical judgement, to consider combinations in certain circumstances.</p></div><div id="ch6.s1.9.2.6"><h5>Adults aged over 18</h5><p>For adults, medication was recommended as first line. Clinical evidence from the pharmacological review found medication to be effective. Clinical opinion also agreed with this. There is limited cost effectiveness in adults regarding whether pharmacological or non-pharmacological treatment is more cost effective. Extrapolating from the atomoxetine child model – CBT is the most common form of non-pharmacological treatment provided to adults, and so taking the sensitivity analysis from the atomoxetine model where behavioural therapy was individual tells us that medication is likely to be more cost effective, because of the resource use involved in providing individual behavioural therapy. Non-pharmacological treatment was considered however in the recommendations in specific circumstances. The previous guideline model on combination treatment versus medication in adults who are stable on medication but have remaining impairment (which had a 1 year time horizon and used only two studies for effect) found individual CBT to not be cost effective. Although this model was in the right population, in terms of being in partial responders to drugs (as we are not offering combination to everyone), again the previous arguments still stand that it was considered to have limitations because the trials may not be capturing the full effect of the intervention, which would increase response rates and make the intervention more cost effective. The committee agreed that the previous guideline recommendations about considering combinations in a certain group of adults should be carried forward on clinical grounds, as cost effectiveness was uncertain at best, rather than definitive. This is good current practice and not likely to have a resource impact.</p></div></div><div id="ch6.s1.9.3"><h4>1.9.3. Other factors the committee took into account</h4><p>The committee agreed that the two treatment approaches target different aspects of ADHD and should not be seen as an either or option and treatment should be focused on the person’s needs. The committee noted that in an area where the evidence base is not definitive and the interventions under review have very different benefit and harm profiles, the element of patient choice and preference is of particular importance. 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Health Services Research. 2007; 42(1 I):165–182 [<a href="/pmc/articles/PMC1955245/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1955245</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/17355587" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17355587</span></a>]</div></dd><dt>19.</dt><dd><div class="bk_ref" id="ch6.r19">Gallucci
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K, Janssen
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TW, Bink
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M, van Mourik
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|
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BL, Aman
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MG, Arnold
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LE, Hyman
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SL, Tumuluru
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RV, Lecavalier
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|
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SA, Waschbusch
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DA, Gnagy
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EM, Onyango
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AN, Burrows-MacLean
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H, Sciberras
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F, Gerner
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B, Efron
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T, Graf
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T, Jacob
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TWP, Bink
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PS, Arnold
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LE, Swanson
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PS, Garcia
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|
||
P. A randomized controlled trial of cognitive behavioral therapy for ADHD in medication-treated adolescents. Journal of Child Psychology and Psychiatry and Allied Disciplines. 2016; 57(11):1218–1226 [<a href="/pmc/articles/PMC5026858/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5026858</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26990084" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26990084</span></a>]</div></dd><dt>56.</dt><dd><div class="bk_ref" id="ch6.r56">Storebo
|
||
OJ, Gluud
|
||
C, Winkel
|
||
P, Simonsen
|
||
E. Social-skills and parental training plus standard treatment versus standard treatment for children with ADHD--the randomised SOSTRA trial. PloS One. 2012; 7(6):e37280 [<a href="/pmc/articles/PMC3380035/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3380035</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22745657" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22745657</span></a>]</div></dd><dt>57.</dt><dd><div class="bk_ref" id="ch6.r57">Storebo
|
||
OJ, Pedersen
|
||
J, Skoog
|
||
M, Thomsen
|
||
PH, Winkel
|
||
P, Gluud
|
||
C
|
||
et al. Randomised social-skills training and parental training plus standard treatment versus standard treatment of children with attention deficit hyperactivity disorder - the SOSTRA trial protocol. Trials. 2011; 12:18 [<a href="/pmc/articles/PMC3038941/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3038941</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21255399" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21255399</span></a>]</div></dd><dt>58.</dt><dd><div class="bk_ref" id="ch6.r58">Svanborg
|
||
P, Thernlund
|
||
G, Gustafsson
|
||
PA, Hagglof
|
||
B, Poole
|
||
L, Kadesjo
|
||
B. Efficacy and safety of atomoxetine as add-on to psychoeducation in the treatment of attention deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled study in stimulant-naive Swedish children and adolescents. European Child and Adolescent Psychiatry. 2009; 18(4):240–249 [<a href="https://pubmed.ncbi.nlm.nih.gov/19156355" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19156355</span></a>]</div></dd><dt>59.</dt><dd><div class="bk_ref" id="ch6.r59">Svanborg
|
||
P, Thernlund
|
||
G, Gustafsson
|
||
PA, Hagglof
|
||
B, Schacht
|
||
A, Kadesjo
|
||
B. Atomoxetine improves patient and family coping in attention deficit/hyperactivity disorder: A randomized, double-blind, placebo-controlled study in Swedish children and adolescents. European Child and Adolescent Psychiatry. 2009; 18(12):725–735 [<a href="/pmc/articles/PMC2770135/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2770135</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19466476" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19466476</span></a>]</div></dd><dt>60.</dt><dd><div class="bk_ref" id="ch6.r60">Tamm
|
||
L, Adinoff
|
||
B, Nakonezny
|
||
PA, Winhusen
|
||
T, Riggs
|
||
P. Attention-deficit/hyperactivity disorder subtypes in adolescents with comorbid substance-use disorder. American Journal of Drug and Alcohol Abuse. 2012; 38(1):93–100 [<a href="/pmc/articles/PMC3441182/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3441182</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21834613" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21834613</span></a>]</div></dd><dt>61.</dt><dd><div class="bk_ref" id="ch6.r61">Thurstone
|
||
C, Riggs
|
||
PD, Salomonsen-Sautel
|
||
S, Mikulich-Gilbertson
|
||
SK. Randomized, controlled trial of atomoxetine for attention-deficit/hyperactivity disorder in adolescents with substance use disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2010; 49(6):573–582 [<a href="/pmc/articles/PMC2876346/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2876346</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20494267" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20494267</span></a>]</div></dd><dt>62.</dt><dd><div class="bk_ref" id="ch6.r62">Van der Oord
|
||
S, Prins
|
||
PJM, Oosterlaan
|
||
J, Emmelkamp
|
||
PMG. Does brief, clinically based, intensive multimodal behavior therapy enhance the effects of methylphenidate in children with ADHD?
|
||
European Child and Adolescent Psychiatry. 2007; 16(1):48–57 [<a href="https://pubmed.ncbi.nlm.nih.gov/16972117" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16972117</span></a>]</div></dd><dt>63.</dt><dd><div class="bk_ref" id="ch6.r63">Vidal
|
||
R, Castells
|
||
J, Richarte
|
||
V, Palomar
|
||
G, Garcia
|
||
M, Nicolau
|
||
R
|
||
et al. Group therapy for adolescents with attention-deficit/hyperactivity disorder: a randomized controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry. 2015; 54(4):275–282 [<a href="https://pubmed.ncbi.nlm.nih.gov/25791144" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25791144</span></a>]</div></dd><dt>64.</dt><dd><div class="bk_ref" id="ch6.r64">Warden
|
||
D, Riggs
|
||
PD, Min
|
||
SJ, Mikulich-Gilbertson
|
||
SK, Tamm
|
||
L, Trello-Rishel
|
||
K
|
||
et al. Major depression and treatment response in adolescents with ADHD and substance use disorder. Drug and Alcohol Dependence. 2012; 120(1-3):214–219 [<a href="/pmc/articles/PMC3245790/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3245790</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21885210" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21885210</span></a>]</div></dd><dt>65.</dt><dd><div class="bk_ref" id="ch6.r65">Waxmonsky
|
||
JG, Waschbusch
|
||
DA, Pelham
|
||
WE, Draganac-Cardona
|
||
L, Rotella
|
||
B, Ryan
|
||
L. Effects of atomoxetine with and without behavior therapy on the school and home functioning of children with attention-deficit/hyperactivity disorder. Journal of Clinical Psychiatry. 2010; 71(11):1535–1551 [<a href="https://pubmed.ncbi.nlm.nih.gov/20673557" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20673557</span></a>]</div></dd><dt>66.</dt><dd><div class="bk_ref" id="ch6.r66">Weiss
|
||
M, Murray
|
||
C, Wasdell
|
||
M, Greenfield
|
||
B, Giles
|
||
L, Hechtman
|
||
L. A randomized controlled trial of CBT therapy for adults with ADHD with and without medication. BMC Psychiatry. 2012; 12:30 [<a href="/pmc/articles/PMC3414742/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3414742</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22480189" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22480189</span></a>]</div></dd><dt>67.</dt><dd><div class="bk_ref" id="ch6.r67">Young
|
||
S, Emilsson
|
||
B, Sigurdsson
|
||
JF, Khondoker
|
||
M, Philipp-Wiegmann
|
||
F, Baldursson
|
||
G
|
||
et al. A randomized controlled trial reporting functional outcomes of cognitive-behavioural therapy in medication-treated adults with ADHD and comorbid psychopathology. European Archives of Psychiatry and Clinical Neuroscience. 2017; 267(3):267–276 [<a href="/pmc/articles/PMC5357275/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5357275</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27752827" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27752827</span></a>]</div></dd><dt>68.</dt><dd><div class="bk_ref" id="ch6.r68">Young
|
||
S, Khondoker
|
||
M, Emilsson
|
||
B, Sigurdsson
|
||
JF, Philipp-Wiegmann
|
||
F, Baldursson
|
||
G
|
||
et al. Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: A randomized controlled trial using multi-level analysis. Psychological Medicine. 2015; 45(13):2793–2804 [<a href="/pmc/articles/PMC4595859/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4595859</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26022103" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26022103</span></a>]</div></dd><dt>69.</dt><dd><div class="bk_ref" id="ch6.r69">Zupancic
|
||
JAF, Miller
|
||
A, Raina
|
||
P. A review of therapies for attention deficit/hyperactivity disorder, Part 3: Economic evaluation of pharmaceutical and psychological/behavioural therapies for attentiondeficit/ hyperactivity disorder. Ottawa. Canadian Coordinating Office for Health Technology Assessment, 1998. Available from: <a href="https://www.cadth.ca/media/pdf/adhd_tr_e.pdf" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>.cadth.ca<wbr style="display:inline-block"></wbr>/media/pdf/adhd_tr_e.pdf</a></div></dd></dl></div><div id="appendixesappgroup6"><h2 id="_appendixesappgroup6_">Appendices</h2><div id="ch6.appa"><h3>Appendix A. Review protocols</h3><div id="ch6.appa.tab1" class="table"><h3><span class="label">Table 44</span><span class="title">Review protocol: Combined pharmacological and non-pharmacological treatment</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appa.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appa.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Field</th><th id="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Content</th></tr></thead><tbody><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review question</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">What is the most clinically and cost-effective combination of pharmacological and non-pharmacological treatment for people with ADHD?</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Type of review question</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Intervention</p>
|
||
<p>A review of health economic evidence related to the same review question was conducted in parallel with this review. For details see the health economic review protocol for this NICE guideline.</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objective of the review</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To identify the most clinically and cost-effective combination of pharmacological and/or non-pharmacological treatment for people with ADHD</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – population / disease / condition / issue / domain</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Children, young people and adults with ADHD.</p>
|
||
<p>Stratified by age:
|
||
<ul id="ch6.l40"><li id="ch6.lt121" class="half_rhythm"><div><5 years</div></li><li id="ch6.lt122" class="half_rhythm"><div>5 to 18 years</div></li><li id="ch6.lt123" class="half_rhythm"><div>>18 years</div></li></ul>
|
||
Note that papers will not be included if their population has been selected exclusively on the basis of response or tolerance to an intervention under investigation</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – interventions</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Pharmacological treatments (mixed, stimulants (including methylphenidate, dexamfetamine and lisdexamfetamine), atomoxetine)</p>
|
||
<p>Non-pharmacological treatments (parent/family/carer training, CBT/DBT, psychoeducation, attention/memory/cognitive training, neurofeedback, relaxation techniques, organisational skills/school or workplace targeted interventions, exercise, outdoor activities</p>
|
||
<p>Combinations of pharmacological and non-pharmacological treatments</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – comparator(s) / control or reference (gold) standard</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Any pharmacological treatment versus any non-pharmacological treatment</p>
|
||
<p>Any combined treatment versus any pharmacological/non-pharmacological treatment alone</p>
|
||
<p>Any combined treatment versus any other combined treatment</p>
|
||
<p>Any combined treatment versus usual care</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes and prioritisation</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Outcomes to be extracted for end of intervention and latest follow-up if both available. Outcomes to be stratified into short term (up to 3 months follow-up) and long term (>3 months follow-up). Where multiple timepoints are reported within each definition, the longest timepoint only will be extracted.</p>
|
||
<p><b>Critical:</b>
|
||
<ul id="ch6.l41"><li id="ch6.lt124" class="half_rhythm"><div>Quality of life [continuous]</div></li><li id="ch6.lt125" class="half_rhythm"><div>ADHD symptoms (total; parent/partner/carer) [continuous]</div></li><li id="ch6.lt126" class="half_rhythm"><div>ADHD symptoms (total; teacher) [continuous]</div></li><li id="ch6.lt127" class="half_rhythm"><div>ADHD symptoms (total; self-rated except for children <13) [continuous]</div></li><li id="ch6.lt128" class="half_rhythm"><div>ADHD symptoms (total; investigator) [continuous]</div></li><li id="ch6.lt129" class="half_rhythm"><div>ADHD symptoms (inattention; parent/partner/carer) [continuous]</div></li><li id="ch6.lt130" class="half_rhythm"><div>ADHD symptoms (inattention; teacher) [continuous]</div></li><li id="ch6.lt131" class="half_rhythm"><div>ADHD symptoms (inattention; self- except for children <13) [continuous]</div></li><li id="ch6.lt132" class="half_rhythm"><div>ADHD symptoms (inattention; investigator) [continuous]</div></li><li id="ch6.lt133" class="half_rhythm"><div>ADHD symptoms (hyperactivity/impulsivity; parent/partner/carer) [continuous]</div></li><li id="ch6.lt134" class="half_rhythm"><div>ADHD symptoms (hyperactivity/impulsivity; teacher) [continuous]</div></li><li id="ch6.lt135" class="half_rhythm"><div>ADHD symptoms (hyperactivity/impulsivity; self-rated except for children <13) [continuous]</div></li><li id="ch6.lt136" class="half_rhythm"><div>ADHD symptoms (hyperactivity/impulsivity; investigator) [continuous]</div></li><li id="ch6.lt137" class="half_rhythm"><div>Clinical Global Impressions scale – improved (much improved or very much improved) [dichotomous]</div></li></ul>
|
||
<b>Important:</b>
|
||
<ul id="ch6.l42"><li id="ch6.lt138" class="half_rhythm"><div>Discontinuation due to intervention (for example perceived lack of efficacy, adverse events) [dichotomous]</div></li><li id="ch6.lt139" class="half_rhythm"><div>Serious adverse events [dichotomous]</div></li><li id="ch6.lt140" class="half_rhythm"><div>Behavioural measures [continuous]</div></li><li id="ch6.lt141" class="half_rhythm"><div>Emotional dysregulation [continuous]</div></li><li id="ch6.lt142" class="half_rhythm"><div>Academic outcomes (literacy, numeracy or combined) [continuous]</div></li></ul></p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – study design</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs, systematic reviews of RCTs</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other inclusion exclusion criteria</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusions:
|
||
<ul id="ch6.l43"><li id="ch6.lt143" class="half_rhythm"><div>Crossover trials with inappropriate washout period</div></li><li id="ch6.lt144" class="half_rhythm"><div>Pharmacological treatment received <2 weeks</div></li><li id="ch6.lt145" class="half_rhythm"><div>Trials that only include responders to treatment under investigation</div></li><li id="ch6.lt146" class="half_rhythm"><div>ADHD diagnosis made not using DSM-III/ICD-910 or later versions of these</div></li><li id="ch6.lt147" class="half_rhythm"><div>Studies published after the publication of DSM-III (1978) will be included if describe their population as having a formal diagnosis of ADHD</div></li><li id="ch6.lt148" class="half_rhythm"><div>Studies evaluating treatments for ADHD in a population of people with ASD will be included if no formal diagnosis of ADHD has been made, but evidence of moderate to severe symptoms of hyperactivity, impulsivity, and/or inattention is demonstrated according to validated symptom questionnaires)</div></li></ul></td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Proposed sensitivity / subgroup analysis, or meta-regression</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Previous treatment and response of population will be used for subgroup analysis in the case of heterogeneity.</p>
|
||
<p>Studies including dietary interventions will only be included where dietary interventions are combined with pharmacological treatment and compared to an intervention other than dietary interventions alone.</p>
|
||
<p>Dichotomous data for ADHD symptom scales other than CGI-I, will only be extracted if continuous data is not available and the definition of improved used is consistent with at least a 20% reduction in symptoms from baseline.</p>
|
||
<p>Appraisal of methodological quality: The methodological quality of each study will be assessed using NICE checklists and GRADE.</p>
|
||
<p>Stratification:
|
||
<ul id="ch6.l44"><li id="ch6.lt149" class="half_rhythm"><div>Age
|
||
<ul id="ch6.l45" class="circle"><li id="ch6.lt150" class="half_rhythm"><div>Pre-schoolers (under 6 years)</div></li><li id="ch6.lt151" class="half_rhythm"><div>Children and young people (6-17 years)</div></li><li id="ch6.lt152" class="half_rhythm"><div>Adults (>18 years)</div></li></ul></div></li></ul>
|
||
Subgroups:
|
||
<ul id="ch6.l46"><li id="ch6.lt153" class="half_rhythm"><div>Comorbidities:
|
||
<ul id="ch6.l47" class="circle"><li id="ch6.lt154" class="half_rhythm"><div>Intellectual disability (</>70 IQ)</div></li><li id="ch6.lt155" class="half_rhythm"><div>Autism spectrum (including Asperger’s, PDD, NOS/atypical)</div></li><li id="ch6.lt156" class="half_rhythm"><div>Neurological disorder (epilepsy)</div></li><li id="ch6.lt157" class="half_rhythm"><div>Affective disorder (depression and anxiety all combined)</div></li><li id="ch6.lt158" class="half_rhythm"><div>Tic disorder and Tourette’s</div></li><li id="ch6.lt159" class="half_rhythm"><div>Personality disorder</div></li><li id="ch6.lt160" class="half_rhythm"><div>Addiction</div></li></ul></div></li><li id="ch6.lt161" class="half_rhythm"><div>Age:
|
||
<ul id="ch6.l48" class="circle"><li id="ch6.lt162" class="half_rhythm"><div>Adults (18-65 years)</div></li><li id="ch6.lt163" class="half_rhythm"><div>Older adults (>65 years)</div></li></ul></div></li><li id="ch6.lt164" class="half_rhythm"><div>Severity
|
||
<ul id="ch6.l49" class="circle"><li id="ch6.lt165" class="half_rhythm"><div>Mild, moderate and severe</div></li></ul></div></li><li id="ch6.lt166" class="half_rhythm"><div>Population
|
||
<ul id="ch6.l50" class="circle"><li id="ch6.lt167" class="half_rhythm"><div>Previous use of interventions, degree of response</div></li><li id="ch6.lt168" class="half_rhythm"><div>Secure estate</div></li><li id="ch6.lt169" class="half_rhythm"><div>Other adults</div></li></ul></div></li><li id="ch6.lt170" class="half_rhythm"><div>Dose
|
||
<ul id="ch6.l51" class="circle"><li id="ch6.lt171" class="half_rhythm"><div>Low</div></li><li id="ch6.lt172" class="half_rhythm"><div>Medium</div></li><li id="ch6.lt173" class="half_rhythm"><div>High</div></li></ul></div></li><li id="ch6.lt174" class="half_rhythm"><div>Method of titration
|
||
<ul id="ch6.l52" class="circle"><li id="ch6.lt175" class="half_rhythm"><div>Fixed dosage</div></li><li id="ch6.lt176" class="half_rhythm"><div>Titrate to optimal dose</div></li></ul></div></li><li id="ch6.lt177" class="half_rhythm"><div>Diagnostic method
|
||
<ul id="ch6.l53" class="circle"><li id="ch6.lt178" class="half_rhythm"><div>DSM-III+</div></li><li id="ch6.lt179" class="half_rhythm"><div>ICD-10</div></li></ul></div></li><li id="ch6.lt180" class="half_rhythm"><div>Country
|
||
<ul id="ch6.l54" class="circle"><li id="ch6.lt181" class="half_rhythm"><div>UK, Europe, USA, Japan. Other countries to allocate as appropriate.</div></li></ul></div></li></ul>
|
||
For non-pharmacological interventions:
|
||
<ul id="ch6.l55"><li id="ch6.lt182" class="half_rhythm"><div>Mode of delivery</div></li><li id="ch6.lt183" class="half_rhythm"><div>Self-help</div></li><li id="ch6.lt184" class="half_rhythm"><div>Facilitated remotely (i.e. online, telephone support)</div></li><li id="ch6.lt185" class="half_rhythm"><div>Face to face (1 on 1)</div></li><li id="ch6.lt186" class="half_rhythm"><div>Face to face (group interventions)</div></li><li id="ch6.lt187" class="half_rhythm"><div>Place of delivery</div></li><li id="ch6.lt188" class="half_rhythm"><div>In educational setting (children or young adults)</div></li><li id="ch6.lt189" class="half_rhythm"><div>Home setting</div></li><li id="ch6.lt190" class="half_rhythm"><div>Clinic setting</div></li><li id="ch6.lt191" class="half_rhythm"><div>Secure estate</div></li></ul></p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Selection process – duplicate screening / selection / analysis</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A sample of at least 10% of the abstract lists were double-sifted by a senior research fellow and discrepancies rectified, with committee input where consensus could not be reached, for more information please see the separate Methods report for this guideline.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data management (software)</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Databases: Medline, Embase, the Cochrane Library, Psychinfo</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Information sources – databases and dates</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Clinical search databases to be used: Medline, Embase, Cochrane</p>
|
||
<p>Library,PsycINFO</p>
|
||
<p>Date: From October 2007</p>
|
||
<p>Health economics search databases to be used: Medline, Embase, NHSEED, HTA</p>
|
||
<p>Date: Medline, Embase from 2014</p>
|
||
<p>NHSEED, HTA – from 2008</p>
|
||
<p>Language: Restrict to English only</p>
|
||
<p>Supplementary search techniques: backward citation searching</p>
|
||
<p>Key papers: Not known</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Identify if an update</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not an update</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Author contacts</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<a href="https://www.nice.org.uk/guidance/cg72" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>.nice.org.uk/guidance/cg72</a>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Highlight if amendment to previous protocol</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not an amendment</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy – for one database</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see <a href="#ch6.appb">appendix B</a></td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data collection process – forms / duplicate</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A standardised evidence table format will be used, and published as <a href="#ch6.appd">appendix D</a> of the evidence report.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data items – define all variables to be collected</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see evidence tables in <a href="#ch6.appd">Appendix D</a> (clinical evidence tables) or <a href="#ch6.apph">H</a> (health economic evidence tables).</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for assessing bias at outcome / study level</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Standard study checklists were used to critically appraise individual studies. For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></p>
|
||
<p>The risk of bias across all available evidence was evaluated for each outcome using an adaptation of the ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) toolbox’ developed by the international GRADE working group <a href="http://www.gradeworkinggroup.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>.gradeworkinggroup.org/</a></p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Criteria for quantitative synthesis</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.4 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for quantitative analysis – combining studies and exploring (in)consistency</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the separate Methods report for this guideline.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-bias assessment – publication bias, selective reporting bias</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Confidence in cumulative evidence</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see sections 6.4 and 9.1 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a> and the methods report of this guideline</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rationale / context – what is known</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the introduction to the evidence review.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Describe contributions of authors and guarantor</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>A <a href="https://www.nice.org.uk/guidance/cg72/history" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">multidisciplinary committee</a> developed the evidence review. The committee was convened by the National Guideline Centre (NGC) and chaired by Gillian Baird in line with section 3 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a> and the methods report of this guideline.</p>
|
||
<p>Staff from NGC undertook systematic literature searches, critically appraised the evidence, conducted meta-analysis and cost-effectiveness analysis where appropriate, and drafted the evidence review in collaboration with the committee. For details please see <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sources of funding / support</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NGC is funded by NICE and hosted by the Royal College of Physicians.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Name of sponsor</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NGC is funded by NICE and hosted by the Royal College of Physicians.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Roles of sponsor</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE funds NGC to develop guidelines for those working in the NHS, public health and social care in England.</td></tr><tr><td headers="hd_h_ch6.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PROSPERO registration number</td><td headers="hd_h_ch6.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not registered</td></tr></tbody></table></div></div><div id="ch6.appa.tab2" class="table"><h3><span class="label">Table 45</span><span class="title">Health economic review protocol</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appa.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appa.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Review question</th><th id="hd_h_ch6.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">All questions – health economic evidence</th></tr></thead><tbody><tr><td headers="hd_h_ch6.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objectives</td><td headers="hd_h_ch6.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To identify health economic studies relevant to any of the review questions.</td></tr><tr><td headers="hd_h_ch6.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search criteria</td><td headers="hd_h_ch6.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Populations, interventions and comparators must be as specified in the clinical review protocols in <a href="#ch6.appa">appendix A</a> above.</p>
|
||
<p>Studies must be of a relevant health economic study design (cost–utility analysis, cost-effectiveness analysis, cost–benefit analysis, cost–consequences analysis, comparative cost analysis).</p>
|
||
<p>Studies must not be a letter, editorial or commentary, or a review of health economic evaluations. (Recent reviews will be ordered although not reviewed. The bibliographies will be checked for relevant studies, which will then be ordered.)</p>
|
||
<p>Unpublished reports will not be considered unless submitted as part of a call for evidence.</p>
|
||
<p>Studies must be in English.</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy</td><td headers="hd_h_ch6.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A health economic study search will be undertaken using population-specific terms and a health economic study filter – see <a href="#ch6.appb">appendix B</a>. For questions being updated, the search will be run from December 2007, which was the cut-off date for the searches conducted for NICE guideline CG72</td></tr><tr><td headers="hd_h_ch6.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review strategy</td><td headers="hd_h_ch6.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Studies not meeting any of the search criteria above will be excluded. Studies published before 2001, abstract-only studies and studies from non-OECD countries or the USA will also be excluded.</p>
|
||
<p>Studies published after 2001 that were included in the previous guideline will be reassessed for inclusion and may be included or selectively excluded based on their relevance to the questions covered in this update and whether more applicable evidence is also identified.</p>
|
||
<p>Each remaining study will be assessed for applicability and methodological limitations using the NICE economic evaluation checklist which can be found in <a href="#ch6.apph">appendix H</a> of Developing NICE guidelines: the manual (2014).<a class="bk_pop" href="#ch6.r46"><sup>46</sup></a></p>
|
||
<p>Inclusion and exclusion criteria</p>
|
||
<p>If a study is rated as both ‘Directly applicable’ and with ‘Minor limitations’ then it will be included in the guideline. A health economic evidence table will be completed and it will be included in the health economic evidence profile.</p>
|
||
<p>If a study is rated as either ‘Not applicable’ or with ‘Very serious limitations’ then it will usually be excluded from the guideline. If it is excluded then a health economic evidence table will not be completed and it will not be included in the health economic evidence profile.</p>
|
||
<p>If a study is rated as ‘Partially applicable’, with ‘Potentially serious limitations’ or both then there is discretion over whether it should be included.</p>
|
||
<p>Where there is discretion</p>
|
||
<p>The health economist will make a decision based on the relative applicability and quality of the available evidence for that question, in discussion with the guideline committee if required. The ultimate aim is to include health economic studies that are helpful for decision-making in the context of the guideline and the current NHS setting. If several studies are considered of sufficiently high applicability and methodological quality that they could all be included, then the health economist, in discussion with the committee if required, may decide to include only the most applicable studies and to selectively exclude the remaining studies. All studies excluded on the basis of applicability or methodological limitations will be listed with explanation as excluded health economic studies in <a href="#ch6.appi">appendix I</a>.</p>
|
||
<p>The health economist will be guided by the following hierarchies.</p>
|
||
<p>Setting:</p>
|
||
<p>UK NHS (most applicable).</p>
|
||
<p>OECD countries with predominantly public health insurance systems (for example, France, Germany, Sweden).</p>
|
||
<p>OECD countries with predominantly private health insurance systems (for example, Switzerland).</p>
|
||
<p>Studies set in non-OECD countries or in the USA will be excluded before being assessed for applicability and methodological limitations.</p>
|
||
<p>Health economic study type:</p>
|
||
<p>Cost–utility analysis (most applicable).</p>
|
||
<p>Other type of full economic evaluation (cost–benefit analysis, cost-effectiveness analysis, cost–consequences analysis).</p>
|
||
<p>Comparative cost analysis.</p>
|
||
<p>Non-comparative cost analyses including cost-of-illness studies will be excluded before being assessed for applicability and methodological limitations.</p>
|
||
<p>Year of analysis:</p>
|
||
<p>The more recent the study, the more applicable it will be.</p>
|
||
<p>Studies published in 2001 or later (including any such studies included in the previous guideline) but that depend on unit costs and resource data entirely or predominantly from before 2001 will be rated as ‘Not applicable’.</p>
|
||
<p>Studies published before 2001 (including any such studies included in the previous guideline) will be excluded before being assessed for applicability and methodological limitations.</p>
|
||
<p>Quality and relevance of effectiveness data used in the health economic analysis:</p>
|
||
<p>The more closely the clinical effectiveness data used in the health economic analysis match with the outcomes of the studies included in the clinical review the more useful the analysis will be for decision-making in the guideline.</p>
|
||
<p>Economic evaluations that are based on studies excluded from the clinical review will be excluded.</p>
|
||
</td></tr></tbody></table></div></div></div><div id="ch6.appb"><h3>Appendix B. Literature search strategies</h3><p>The literature searches for this review are detailed below and complied with the methodology outlined in Developing NICE guidelines: the manual, Oct 2014, updated 2017. <a href="https://www.nice.org.uk/guidance/pmg20/resources/developing-nice-guidelines-the-manual-pdf-72286708700869" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www.nice.org.uk/guidance/pmg20/resources/developing-nice-guidelines-the-manual-pdf-72286708700869</a></p><p><i>For more detailed information, please see the</i> Methodology <i>Review</i>.</p><div id="ch6.appb.s1"><h4>B.1. Clinical search literature search strategy</h4><p>Searches for were constructed using a PICO framework where population (P) terms were combined with Intervention (I) and in some cases Comparison (C) terms. Outcomes (O) are rarely used in search strategies for interventions as these concepts may not be well described in title, abstract or indexes and therefore difficult to retrieve. Search filters were applied to the search where appropriate.</p><div id="ch6.appb.tab1" class="table"><h3><span class="label">Table 46</span><span class="title">Database date parameters and filters used</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Database</th><th id="hd_h_ch6.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dates searched</th><th id="hd_h_ch6.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search filter used</th></tr></thead><tbody><tr><td headers="hd_h_ch6.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medline (OVID)</td><td headers="hd_h_ch6.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">01 October 2007 – 28 April 2017</td><td headers="hd_h_ch6.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Exclusions</p>
|
||
<p>Randomised controlled trials</p>
|
||
<p>Systematic review studies</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase (OVID)</td><td headers="hd_h_ch6.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">01 October 2007 – 28 April 2017</td><td headers="hd_h_ch6.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Exclusions</p>
|
||
<p>Randomised controlled trials</p>
|
||
<p>Systematic review studies</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The Cochrane Library (Wiley)</td><td headers="hd_h_ch6.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Cochrane Reviews 2007 to 2017 Issue 4 of 12</p>
|
||
<p>CENTRAL 2007 to 2017 Issue 3 of 12</p>
|
||
<p>DARE and NHSEED 2007 to 2015 Issue 1 of 4</p>
|
||
<p>HTA 2007 to 2017 Issue 1 of 4</p>
|
||
</td><td headers="hd_h_ch6.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr><tr><td headers="hd_h_ch6.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PsycINFO (ProQuest)</td><td headers="hd_h_ch6.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">01 October 2007 – 28 April 2017</td><td headers="hd_h_ch6.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Exclusions</p>
|
||
<p>Randomised controlled trials</p>
|
||
<p>Systematic review studies</p>
|
||
</td></tr></tbody></table></div></div><div id="ch6.appb.tab2" class="table"><h3><span class="title">Medline (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab2_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“attention deficit and disruptive behavior disorders”/ or attention deficit disorder with hyperactivity/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 (adolescent* or adult* or behav* or child* or class or classes or classroom* or condition* or difficult* or disorder* or learn* or people or person* or poor or problem* or process* or youngster*)).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 disorder*).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ADHD or addh or ad hd or ad??hd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attenti* adj3 deficit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((hyperkin* or hyper kin*) adj1 (syndrome* or disorder*)) or hkd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(minimal brain adj2 (dysfunct* or disorder*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1-7</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Child Development Disorders, Pervasive/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(autistic or autism or asperger*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">pervasive developmental disorder*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(asd or pdd or pdd-nos).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/9-12</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hyperkinesis/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hyperactiv* or inattent* or hyperkin* or hyper-kin*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 or 15</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 and 16</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8 or 17</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 18 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">news/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp historical article/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">comment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/20-27</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28 not 29</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Animals, Laboratory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp animal experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/30-36</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19 not 37</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">controlled clinical trial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomi#ed.ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">placebo.ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">drug therapy.fs.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomly.ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">trial.ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">groups.ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/39-46</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Clinical Trials as topic.sh.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">trial.ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/39-42,44,48-49</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-Analysis/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-Analysis as Topic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(meta analy* or metanaly* or metaanaly* or meta regression).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((systematic* or evidence*) adj3 (review* or overview*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(reference list* or bibliograph* or hand search* or manual search* or relevant journals).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(search strategy or search criteria or systematic search or study selection or data extraction).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(search* adj4 literature).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(medline or pubmed or cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or science citation index or bids or cancerlit).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cochrane.jw.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((multiple treatment* or indirect or mixed) adj2 comparison*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/51-60</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38 and (50 or 61)</td></tr></tbody></table></div></div><div id="ch6.appb.tab3" class="table"><h3><span class="title">Embase (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab3_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">attention deficit disorder/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 (adolescent* or adult* or behav* or child* or class or classes or classroom* or condition* or difficult* or disorder* or learn* or people or person* or poor or problem* or process* or youngster*)).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 disorder*).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ADHD or addh or ad hd or ad??hd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attenti* adj3 deficit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((hyperkin* or hyper kin*) adj1 (syndrome* or disorder*)) or hkd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(minimal brain adj2 (dysfunct* or disorder*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1-7</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp autism/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(autistic or autism or asperger*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">pervasive developmental disorder*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(asd or pdd or pdd-nos).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/9-12</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hyperactivity/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hyperkinesia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hyperactiv* or inattent* or hyperkin* or hyper-kin*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/14-16</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 and 17</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8 or 18</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 19 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/21-25</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26 not 27</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/28-35</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20 not 36</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">factorial*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(crossover* or cross over*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((doubl* or singl*) adj blind*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(assign* or allocat* or volunteer* or placebo*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">crossover procedure/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">single blind procedure/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">double blind procedure/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/38-46</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">systematic review/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">meta-analysis/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(meta analy* or metanaly* or metaanaly* or meta regression).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((systematic or evidence) adj3 (review* or overview*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(reference list* or bibliograph* or hand search* or manual search* or relevant journals).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(search strategy or search criteria or systematic search or study selection or data extraction).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(search* adj4 literature).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(medline or pubmed or cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or science citation index or bids or cancerlit).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cochrane.jw.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((multiple treatment* or indirect or mixed) adj2 comparison*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/48-57</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37 and (47 or 58)</td></tr></tbody></table></div></div><div id="ch6.appb.tab4" class="table"><h3><span class="title">Cochrane Library (Wiley) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab4_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[mh ^“attention deficit and disruptive behavior disorders”]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[mh ^“attention deficit disorder with hyperactivity”]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) near/3 (adolescent* or adult* or behav* or child* or class or classes or classroom* or condition* or difficult* or disorder* or learn* or people or person* or poor or problem* or process* or youngster*)):ti</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) near/3 disorder*):ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ADHD or addh or ad next hd or ad-hd):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attenti* near/3 deficit*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((hyperkin* or (hyper near/1 kin*)) near/1 (syndrome* or disorder*)) or hkd):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(minimal near/1 brain near/2 (dysfunct* or disorder*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #1-#8)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[mh “Child Development Disorders, Pervasive”]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(autistic or autism or asperger*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pervasive next developmental next disorder*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(asd or pdd or pdd-nos):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #10-#13)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[mh ^hyperkinesis]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hyperactiv* or inattent* or hyperkin* or hyper-kin*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#15 or #16</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14 and #17</td></tr></tbody></table></div></div><div id="ch6.appb.tab5" class="table"><h3><span class="title">PsycINFO (ProQuest) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab5_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(SU.EXACT.EXPLODE(“Attention Deficit Disorder”) OR TI((attenti* OR disrupt*) NEAR/3 (adolescent* OR adult* OR behav* OR child* OR class OR classes OR classroom* OR condition* OR difficult* OR disorder* OR learn* OR people OR person* OR poor OR problem* OR process* OR youngster*)) OR AB((attenti* OR disrupt*) NEAR/3 disorder*) OR TI,AB(ADHD OR addh OR ad-hd OR ad??hd) OR TI,AB(attenti* NEAR/3 deficit*) OR TI,AB(((hyperkin* OR (hyper-kin*)) NEAR/1 (syndrome* OR disorder*)) OR hkd) OR TI,AB(minimal NEAR/1 brain NEAR/2 (dysfunct* OR disorder*))) OR ((SU.EXACT.EXPLODE(“Autism Spectrum Disorders”) or TI,AB(autistic or autism or asperger*) or TI,AB(pervasive-developmental-disorder*) or TI,AB(asd or pdd or pdd-nos)) AND (SU.EXACT(“Hyperkinesis”) or TI,AB(hyperactiv* or inattent* or hyperkin* or hyper-kin*)))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(su.exact.explode(“clinical trials”) OR ti,ab((clinical OR control*) NEAR/3 trial*) OR ti,ab((single* OR double* OR treble* OR triple*) NEAR/5 (blind* OR mask*)) OR ti,ab(volunteer* OR control-group OR controls) OR su.exact(“placebo”) OR ti,ab(placebo*))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((SU.EXACT(“Literature Review”) or RTYPE(review) or ti(review) or me(literature review)) AND (ti,ab(systematic or evidence or methodol* or quantitative*))) or (SU.EXACT(“Meta Analysis”) or ti,ab(meta-analys* or metanalys* or metaanalys* or meta analys*) or ti,ab((systematic or evidence* or methodol* or quantitative*) near/3 (review* or overview*)) or ti,ab((pool* or combined or combining) near/2 (data or trials or studies or results)) or RTYPE(systematic or meta*) or ME(meta analysis or systematic review))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 AND (2 OR 3)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Limit to English</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NOT (Dissertations & Theses AND Books)</td></tr></tbody></table></div></div></div><div id="ch6.appb.s2"><h4>B.2. Health Economics literature search strategies</h4><div id="ch6.appb.s2.1"><h5>B.2.1. Health economics search strategy</h5><p>Health economic evidence was identified by conducting a broad search relating to ADHD population in NHS Economic Evaluation Database (NHS EED – this ceased to be updated after March 2015) and the Health Technology Assessment database (HTA). NHS EED and HTA databases are hosted by the Centre for Research and Dissemination (CRD). Additional searches were run on Medline and Embase.</p><div id="ch6.appb.tab6" class="table"><h3><span class="label">Table 47</span><span class="title">Database date parameters and filters used</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab6_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.appb.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Database</th><th id="hd_h_ch6.appb.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dates searched</th><th id="hd_h_ch6.appb.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search filter used</th></tr></thead><tbody><tr><td headers="hd_h_ch6.appb.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medline</td><td headers="hd_h_ch6.appb.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2014 – 28 April 2017</td><td headers="hd_h_ch6.appb.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Exclusions</p>
|
||
<p>Health economics</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appb.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase</td><td headers="hd_h_ch6.appb.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2014 – 28 April 2017</td><td headers="hd_h_ch6.appb.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Exclusions</p>
|
||
<p>Health economics</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appb.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Centre for Research and Dissemination (CRD)</td><td headers="hd_h_ch6.appb.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>HTA - 2008 – 28 April 2017</p>
|
||
<p>NHSEED - 2008 to March 2015</p>
|
||
</td><td headers="hd_h_ch6.appb.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr></tbody></table></div></div><div id="ch6.appb.tab7" class="table"><h3><span class="title">Medline (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab7_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“attention deficit and disruptive behavior disorders”/ or attention deficit disorder with hyperactivity/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 (adolescent* or adult* or behav* or child* or class or classes or classroom* or condition* or difficult* or disorder* or learn* or people or person* or poor or problem* or process* or youngster*)).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 disorder*).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ADHD or addh or ad hd or ad??hd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attenti* adj3 deficit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((hyperkin* or hyper kin*) adj1 (syndrome* or disorder*)) or hkd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(minimal brain adj2 (dysfunct* or disorder*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1-7</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 8 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">news/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp historical article/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">comment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/10-17</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18 not 19</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Animals, Laboratory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp animal experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/20-26</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 not 27</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Economics/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Value of life/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp “Costs and Cost Analysis”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Economics, Hospital/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Economics, Medical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Economics, Nursing/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Economics, Pharmaceutical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp “Fees and Charges”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Budgets/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cost*.ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(economic* or pharmaco?economic*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(price* or pricing*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(cost* adj2 (effective* or utilit* or benefit* or minimi* or unit* or estimat* or variable*)).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(financ* or fee or fees).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(value adj2 (money or monetary)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/29-44</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp models, economic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Models, Theoretical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Models, Organizational/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">markov chains/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">monte carlo method/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Decision Theory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(markov* or monte carlo).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">econom* model*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(decision* adj2 (tree* or analy* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/46-54</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28 and (45 or 55)</td></tr></tbody></table></div></div><div id="ch6.appb.tab8" class="table"><h3><span class="title">Embase (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab8_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">attention deficit disorder/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 (adolescent* or adult* or behav* or child* or class or classes or classroom* or condition* or difficult* or disorder* or learn* or people or person* or poor or problem* or process* or youngster*)).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 disorder*).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ADHD or addh or ad hd or ad??hd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attenti* adj3 deficit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((hyperkin* or hyper kin*) adj1 (syndrome* or disorder*)) or hkd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(minimal brain adj2 (dysfunct* or disorder*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1-7</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 8 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/10-14</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 not 16</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/17-24</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 not 25</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">statistical model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp economic aspect/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27 and 28</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*theoretical model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*nonbiological model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">stochastic model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">decision theory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">decision tree/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">monte carlo method/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(markov* or monte carlo).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">econom* model*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(decision* adj2 (tree* or analy* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/29-38</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*health economics/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp *economic evaluation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp *health care cost/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp *fee/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">funding/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cost*.ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(economic* or pharmaco?economic*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(price* or pricing*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(cost* adj2 (effective* or utilit* or benefit* or minimi* or unit* or estimat* or variable*)).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(financ* or fee or fees).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(value adj2 (money or monetary)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/40-52</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26 and (39 or 53)</td></tr></tbody></table></div></div><div id="ch6.appb.tab9" class="table"><h3><span class="title">NHS EED and HTA (CRD) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab9/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab9_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Attention Deficit and Disruptive Behavior Disorders</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Attention Deficit Disorder with Hyperactivity</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((attenti* or disrupt*) adj3 (adolescent* or adult* or behav* or child* or class or classes or classroom* or condition* or difficult* or disorder* or learn* or people or person* or poor or problem* or process* or youngster*))):TI</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((attenti* or disrupt*) adj3 disorder*))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((ADHD or addh or ad hd or ad??hd))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* adj3 deficit*))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((((hyperkin* or hyper kin*) adj1 (syndrome* or disorder*)) or hkd))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((minimal brain adj2 (dysfunct* or disorder*)))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(#9) IN NHSEED, HTA</td></tr></tbody></table></div></div></div><div id="ch6.appb.s2.2"><h5>B.2.2. Quality of Life search strategy</h5><p>Quality of life evidence was identified by conducting a broad search relating to ADHD population in Medline and Embase.</p><div id="ch6.appb.tab10" class="table"><h3><span class="label">Table 48</span><span class="title">Database date parameters and filters used</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab10/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab10_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Database</th><th id="hd_h_ch6.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dates searched</th><th id="hd_h_ch6.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search filters used</th></tr></thead><tbody><tr><td headers="hd_h_ch6.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medline</td><td headers="hd_h_ch6.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2008 – 28 September 2015</td><td headers="hd_h_ch6.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Exclusions</p>
|
||
<p>Quality of life</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase</td><td headers="hd_h_ch6.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2008 – 28 September 2015</td><td headers="hd_h_ch6.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Exclusions</p>
|
||
<p>Quality of life</p>
|
||
</td></tr></tbody></table></div></div><div id="ch6.appb.tab11" class="table"><h3><span class="title">Medline (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab11/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab11_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“attention deficit and disruptive behavior disorders”/ or attention deficit disorder with hyperactivity/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 (adolescent* or adult* or behav* or child* or class or classes or classroom* or condition* or difficult* or disorder* or learn* or people or person* or poor or problem* or process* or youngster*)).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 disorder*).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ADHD or addh or ad hd or ad??hd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attenti* adj3 deficit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((hyperkin* or hyper kin*) adj1 (syndrome* or disorder*)) or hkd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(minimal brain adj2 (dysfunct* or disorder*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1-7</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 8 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">news/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp historical article/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">comment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/10-17</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18 not 19</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Animals, Laboratory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp animal experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/20-26</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 not 27</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">quality-adjusted life years/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(quality adj2 (wellbeing or well being)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">disability adjusted life.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qal* or qtime* or qwb* or daly*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(euroqol* or eq5d* or eq 5*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qol* or hql* or hqol* or h qol* or hrqol* or hr qol*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health utility* or utility score* or disutilit* or utility value*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hui or hui1 or hui2 or hui3).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health* year* equivalent* or hye or hyes).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">discrete choice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">rosser.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(willingness to pay or time tradeoff or time trade off or tto or standard gamble*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf36* or sf 36* or short form 36* or shortform 36* or shortform36*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf20 or sf 20 or short form 20 or shortform 20 or shortform20).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf12* or sf 12* or short form 12* or shortform 12* or shortform12*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf8* or sf 8* or short form 8* or shortform 8* or shortform8*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf6* or sf 6* or short form 6* or shortform 6* or shortform6*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/29-47</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28 and 48</td></tr></tbody></table></div></div><div id="ch6.appb.tab12" class="table"><h3><span class="title">Embase (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appb.tab12/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appb.tab12_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">attention deficit disorder/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 (adolescent* or adult* or behav* or child* or class or classes or classroom* or condition* or difficult* or disorder* or learn* or people or person* or poor or problem* or process* or youngster*)).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attenti* or disrupt*) adj3 disorder*).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ADHD or addh or ad hd or ad??hd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attenti* adj3 deficit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((hyperkin* or hyper kin*) adj1 (syndrome* or disorder*)) or hkd).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(minimal brain adj2 (dysfunct* or disorder*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1-7</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 8 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/10-14</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 not 16</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/17-24</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 not 25</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">quality adjusted life year/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“quality of life index”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">short form 12/ or short form 20/ or short form 36/ or short form 8/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(quality adj2 (wellbeing or well being)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">disability adjusted life.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qal* or qtime* or qwb* or daly*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(euroqol* or eq5d* or eq 5*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qol* or hql* or hqol* or h qol* or hrqol* or hr qol*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health utility* or utility score* or disutilit* or utility value*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hui or hui1 or hui2 or hui3).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health* year* equivalent* or hye or hyes).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">discrete choice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">rosser.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(willingness to pay or time tradeoff or time trade off or tto or standard gamble*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf36* or sf 36* or short form 36* or shortform 36* or shortform36*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf20 or sf 20 or short form 20 or shortform 20 or shortform20).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf12* or sf 12* or short form 12* or shortform 12* or shortform12*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf8* or sf 8* or short form 8* or shortform 8* or shortform8*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf6* or sf 6* or short form 6* or shortform 6* or shortform6*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/27-47</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26 and 48</td></tr></tbody></table></div></div></div></div></div><div id="ch6.appc"><h3>Appendix C. Clinical evidence selection</h3><div id="ch6.appc.fig1" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch6appcf1&p=BOOKS&id=578099_ch6appcf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appcf1.jpg" alt="Image ch6appcf1" class="tileshop" title="Click on image to zoom" /></a></div></div></div><div id="ch6.appd"><h3>Appendix D. Clinical evidence tables</h3><p id="ch6.appd.et1"><a href="/books/NBK578099/bin/ch6-appd-et1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Download PDF</a><span class="small"> (2.1M)</span></p></div><div id="ch6.appe"><h3>Appendix E. Forest plots</h3><div id="ch6.appe.s1"><h4>E.1. Children and young people aged 5 to 18</h4><div id="ch6.appe.s1.1"><h5>E.1.1. Pharmacological treatment versus non-pharmacological treatment</h5><div id="ch6.appe.s1.1.1"><h5>E.1.1.1. Atomoxetine versus PT/FT</h5><div id="ch6.appe.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20ADHD%20symptoms%20(total%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef1.jpg" alt="Figure 1. ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig2" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%202.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef2.jpg" alt="Figure 2. ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 2</span><span class="title">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%203.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef3.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef3.jpg" alt="Figure 3. ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 3</span><span class="title">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig4" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%204.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef4.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef4.jpg" alt="Figure 4. ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 4</span><span class="title">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig5" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%205.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef5.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef5.jpg" alt="Figure 5. ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 5</span><span class="title">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig6" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%206.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef6.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef6.jpg" alt="Figure 6. ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 6</span><span class="title">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig7" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%207.%20Responders%20by%20CGI-I%20(PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef7.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef7.jpg" alt="Figure 7. Responders by CGI-I (PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 7</span><span class="title">Responders by CGI-I (PT, <3 months)</span></h3></div></div><div id="ch6.appe.s1.1.2"><h5>E.1.1.2. Stimulants versus exercise</h5><div id="ch6.appe.fig8" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%208.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef8.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef8.jpg" alt="Figure 8. ADHD symptoms (hyperactivity, parent, SWAN, 0-3, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 8</span><span class="title">ADHD symptoms (hyperactivity, parent, SWAN, 0-3, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig9" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%209.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef9.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef9.jpg" alt="Figure 9. ADHD symptoms (hyperactivity, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 9</span><span class="title">ADHD symptoms (hyperactivity, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig10" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2010.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef10.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef10.jpg" alt="Figure 10. ADHD symptoms (inattention, parent, SWAN, 0-3, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 10</span><span class="title">ADHD symptoms (inattention, parent, SWAN, 0-3, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig11" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2011.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef11.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef11.jpg" alt="Figure 11. ADHD symptoms (inattention, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 11</span><span class="title">ADHD symptoms (inattention, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)</span></h3></div></div><div id="ch6.appe.s1.1.3"><h5>E.1.1.3. Stimulants versus NF</h5><div id="ch6.appe.fig12" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2012.%20ADHD%20symptoms%20(total%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef12.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef12.jpg" alt="Figure 12. ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 12</span><span class="title">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig13" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2013.%20ADHD%20symptoms%20(total%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef13.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef13.jpg" alt="Figure 13. ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 13</span><span class="title">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig14" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2014.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef14.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef14.jpg" alt="Figure 14. ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 14</span><span class="title">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig15" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2015.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef15.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef15.jpg" alt="Figure 15. ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 15</span><span class="title">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig16" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2016.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef16.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef16.jpg" alt="Figure 16. ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 16</span><span class="title">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig17" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2017.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef17.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef17.jpg" alt="Figure 17. ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 17</span><span class="title">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig18" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2018.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef18.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef18.jpg" alt="Figure 18. ADHD symptoms (hyperactivity, parent, SWAN, 0-3, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 18</span><span class="title">ADHD symptoms (hyperactivity, parent, SWAN, 0-3, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig19" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2019.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef19.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef19.jpg" alt="Figure 19. ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 19</span><span class="title">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig20" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2020.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef20.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef20.jpg" alt="Figure 20. ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 20</span><span class="title">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig21" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2021.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef21.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef21.jpg" alt="Figure 21. ADHD symptoms (hyperactivity, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 21</span><span class="title">ADHD symptoms (hyperactivity, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig22" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2022.%20ADHD%20symptoms%20(hyperactivity%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef22.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef22.jpg" alt="Figure 22. ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 22</span><span class="title">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig23" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2023.%20ADHD%20symptoms%20(hyperactivity%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef23.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef23.jpg" alt="Figure 23. ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 23</span><span class="title">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, <3 months)</span></h3></div><div id="ch6.appe.fig24" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2024.%20ADHD%20symptoms%20(hyperactivity%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef24.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef24.jpg" alt="Figure 24. ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 24</span><span class="title">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, >3 months)</span></h3></div><div id="ch6.appe.fig25" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2025.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef25.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef25.jpg" alt="Figure 25. ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 25</span><span class="title">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig26" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2026.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef26.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef26.jpg" alt="Figure 26. ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 26</span><span class="title">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig27" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2027.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef27.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef27.jpg" alt="Figure 27. ADHD symptoms (inattention, parent, SWAN, 0-3, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 27</span><span class="title">ADHD symptoms (inattention, parent, SWAN, 0-3, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig28" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2028.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef28.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef28.jpg" alt="Figure 28. ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 28</span><span class="title">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig29" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2029.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef29.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef29.jpg" alt="Figure 29. ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 29</span><span class="title">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig30" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2030.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef30.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef30.jpg" alt="Figure 30. ADHD symptoms (inattention, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 30</span><span class="title">ADHD symptoms (inattention, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig31" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2031.%20ADHD%20symptoms%20(inattention%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef31.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef31.jpg" alt="Figure 31. ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 31</span><span class="title">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, <3 months)</span></h3></div><div id="ch6.appe.fig32" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2032.%20ADHD%20symptoms%20(inattention%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef32.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef32.jpg" alt="Figure 32. ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 32</span><span class="title">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, >3 months)</span></h3></div><div id="ch6.appe.fig33" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2033.%20ADHD%20symptoms%20(inattention%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef33.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef33.jpg" alt="Figure 33. ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 33</span><span class="title">ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig34" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2034.%20Academic%20(general%2C%20self%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef34.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef34.jpg" alt="Figure 34. Academic (general, self, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 34</span><span class="title">Academic (general, self, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig35" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2035.%20Academic%20(general%2C%20self%2C%201-10%2C%20high%20is%20good%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef35.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef35.jpg" alt="Figure 35. Academic (general, self, 1-10, high is good, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 35</span><span class="title">Academic (general, self, 1-10, high is good, PT <3 months)</span></h3></div><div id="ch6.appe.fig36" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2036.%20Academic%20(general%2C%20self%2C%201-10%2C%20high%20is%20good%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef36.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef36.jpg" alt="Figure 36. Academic (general, self, 1-10, high is good, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 36</span><span class="title">Academic (general, self, 1-10, high is good, PT >3 months)</span></h3></div></div><div id="ch6.appe.s1.1.4"><h5>E.1.1.4. Stimulants + NSST versus stimulants</h5><div id="ch6.appe.fig37" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2037.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef37.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef37.jpg" alt="Figure 37. ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 37</span><span class="title">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig38" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2038.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef38.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef38.jpg" alt="Figure 38. ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 38</span><span class="title">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig39" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2039.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef39.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef39.jpg" alt="Figure 39. ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 39</span><span class="title">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig40" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2040.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef40.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef40.jpg" alt="Figure 40. ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 40</span><span class="title">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)</span></h3></div></div><div id="ch6.appe.s1.1.5"><h5>E.1.1.5. Mixed medication versus PT/FT</h5><div id="ch6.appe.fig41" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2041.%20ADHD%20symptoms%20(total%2C%20teacher%20and%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef41.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef41.jpg" alt="Figure 41. ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 41</span><span class="title">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig42" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2042.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef42.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef42.jpg" alt="Figure 42. ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 42</span><span class="title">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)</span></h3></div><div id="ch6.appe.fig43" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2043.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef43.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef43.jpg" alt="Figure 43. ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 43</span><span class="title">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig44" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2044.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef44.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef44.jpg" alt="Figure 44. ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 44</span><span class="title">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig45" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2045.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef45.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef45.jpg" alt="Figure 45. ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 45</span><span class="title">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig46" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2046.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef46.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef46.jpg" alt="Figure 46. ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 46</span><span class="title">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig47" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2047.%20Academic%20outcomes%20(maths%20accuracy%20%25%2C%20observer%2C%20high%20is%20better%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef47.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef47.jpg" alt="Figure 47. Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 47</span><span class="title">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)</span></h3></div><div id="ch6.appe.fig48" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2048.%20Academic%20outcomes%20(maths%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef48.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef48.jpg" alt="Figure 48. Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 48</span><span class="title">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</span></h3></div><div id="ch6.appe.fig49" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2049.%20Academic%20outcomes%20(reading%20accuracy%20%25%2C%20observer%2C%20high%20is%20better%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef49.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef49.jpg" alt="Figure 49. Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 49</span><span class="title">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)</span></h3></div><div id="ch6.appe.fig50" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2050.%20Academic%20outcomes%20(reading%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef50.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef50.jpg" alt="Figure 50. Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 50</span><span class="title">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</span></h3></div><div id="ch6.appe.fig51" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2051.%20Academic%20outcomes%20(reading%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef51.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef51.jpg" alt="Figure 51. Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 51</span><span class="title">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)</span></h3></div></div></div><div id="ch6.appe.s1.2"><h5>E.1.2. Combined treatment versus non-pharmacological treatment</h5><div id="ch6.appe.s1.2.1"><h5>E.1.2.1. Atomoxetine + PT/FT versus PT/FT</h5><div id="ch6.appe.fig52" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2052.%20ADHD%20symptoms%20(total%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef52.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef52.jpg" alt="Figure 52. ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 52</span><span class="title">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig53" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2053.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef53.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef53.jpg" alt="Figure 53. ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 53</span><span class="title">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig54" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2054.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef54.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef54.jpg" alt="Figure 54. ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 54</span><span class="title">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig55" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2055.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef55.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef55.jpg" alt="Figure 55. ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 55</span><span class="title">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig56" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2056.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef56.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef56.jpg" alt="Figure 56. ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 56</span><span class="title">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig57" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2057.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef57.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef57.jpg" alt="Figure 57. ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 57</span><span class="title">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig58" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2058.%20Responders%20by%20CGI-I%20(PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef58.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef58.jpg" alt="Figure 58. Responders by CGI-I (PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 58</span><span class="title">Responders by CGI-I (PT, <3 months)</span></h3></div></div><div id="ch6.appe.s1.2.2"><h5>E.1.2.2. Atomoxetine + psychoeducation versus psychoeducation</h5><div id="ch6.appe.fig59" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2059.%20Quality%20of%20life%20(parent%20rated%2C%20total%20CHIP-CE%2C%20unclear%20range%2C%20high%20is%20good%20outcome%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef59.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef59.jpg" alt="Figure 59. Quality of life (parent rated, total CHIP-CE, unclear range, high is good outcome, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 59</span><span class="title">Quality of life (parent rated, total CHIP-CE, unclear range, high is good outcome, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig60" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2060.%20ADHD%20symptoms%20(total%2C%20parent%2C%20ADHD-RS%2C%200-25%2C%20high%20is%20poor%2C%20CS%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef60.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef60.jpg" alt="Figure 60. ADHD symptoms (total, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 60</span><span class="title">ADHD symptoms (total, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)</span></h3></div><div id="ch6.appe.fig61" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2061.%20symptoms%20(hyperactivity%2C%20parent%2C%20ADHD-RS%2C%200-25%2C%20high%20is%20poor%2C%20CS%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef61.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef61.jpg" alt="Figure 61. symptoms (hyperactivity, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 61</span><span class="title">symptoms (hyperactivity, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)</span></h3></div><div id="ch6.appe.fig62" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2062.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20ADHD-RS%2C%200-25%2C%20high%20is%20poor%2C%20CS%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef62.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef62.jpg" alt="Figure 62. ADHD symptoms (inattention, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 62</span><span class="title">ADHD symptoms (inattention, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)</span></h3></div><div id="ch6.appe.fig63" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2063.%20Academic%20(parent%20rated%2C%20academic%20CHIP-CE%2C%20unclear%20range%2C%20high%20is%20good%20outcome%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef63.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef63.jpg" alt="Figure 63. Academic (parent rated, academic CHIP-CE, unclear range, high is good outcome, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 63</span><span class="title">Academic (parent rated, academic CHIP-CE, unclear range, high is good outcome, CS, PT <3 months)</span></h3></div></div><div id="ch6.appe.s1.2.3"><h5>E.1.2.3. Atomoxetine + CBT versus CBT</h5><div id="ch6.appe.fig64" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2064.%20ADHD%20symptoms%20(total%2C%20parent%2C%20DSM-IV%20checklist%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef64.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef64.jpg" alt="Figure 64. ADHD symptoms (total, parent, DSM-IV checklist, 0-54, high is poor, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 64</span><span class="title">ADHD symptoms (total, parent, DSM-IV checklist, 0-54, high is poor, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig65" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2065.%20ADHD%20symptoms%20(total%2C%20self%2C%20DSM-IV%20checklist%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef65.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef65.jpg" alt="Figure 65. ADHD symptoms (total, self, DSM-IV checklist, 0-54, high is poor, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 65</span><span class="title">ADHD symptoms (total, self, DSM-IV checklist, 0-54, high is poor, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig66" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2066.%20Responders%20by%20CGI-I%20(PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef66.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef66.jpg" alt="Figure 66. Responders by CGI-I (PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 66</span><span class="title">Responders by CGI-I (PT, <3 months)</span></h3></div></div><div id="ch6.appe.s1.2.4"><h5>E.1.2.4. Stimulants + NF versus NF</h5><div id="ch6.appe.fig67" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2067.%20ADHD%20symptoms%20(total%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef67.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef67.jpg" alt="Figure 67. ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 67</span><span class="title">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig68" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2068.%20ADHD%20symptoms%20(total%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef68.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef68.jpg" alt="Figure 68. ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 68</span><span class="title">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig69" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2069.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef69.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef69.jpg" alt="Figure 69. ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 69</span><span class="title">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig70" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2070.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef70.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef70.jpg" alt="Figure 70. ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 70</span><span class="title">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig71" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2071.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef71.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef71.jpg" alt="Figure 71. ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 71</span><span class="title">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig72" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2072.%20symptoms%20(hyperactivity%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef72.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef72.jpg" alt="Figure 72. symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 72</span><span class="title">symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig73" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2073.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef73.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef73.jpg" alt="Figure 73. ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 73</span><span class="title">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig74" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2074.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef74.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef74.jpg" alt="Figure 74. ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 74</span><span class="title">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig75" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2075.%20ADHD%20symptoms%20(hyperactivity%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef75.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef75.jpg" alt="Figure 75. ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 75</span><span class="title">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, <3 months)</span></h3></div><div id="ch6.appe.fig76" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2076.%20ADHD%20symptoms%20(hyperactivity%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef76.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef76.jpg" alt="Figure 76. ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 76</span><span class="title">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, >3 months)</span></h3></div><div id="ch6.appe.fig77" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2077.%20ADHD%20symptoms%20(hyperactivity%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef77.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef77.jpg" alt="Figure 77. ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 77</span><span class="title">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig78" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2078.%20symptoms%20(inattention%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef78.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef78.jpg" alt="Figure 78. symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 78</span><span class="title">symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig79" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2079.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef79.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef79.jpg" alt="Figure 79. ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 79</span><span class="title">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig80" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2080.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef80.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef80.jpg" alt="Figure 80. ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 80</span><span class="title">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig81" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2081.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef81.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef81.jpg" alt="Figure 81. ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 81</span><span class="title">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig82" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2082.%20ADHD%20symptoms%20(inattention%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef82.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef82.jpg" alt="Figure 82. ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 82</span><span class="title">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, <3 months)</span></h3></div><div id="ch6.appe.fig83" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2083.%20ADHD%20symptoms%20(inattention%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef83.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef83.jpg" alt="Figure 83. ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 83</span><span class="title">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, >3 months)</span></h3></div><div id="ch6.appe.fig84" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2084.%20symptoms%20(inattention%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef84.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef84.jpg" alt="Figure 84. symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 84</span><span class="title">symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig85" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2085.%20Academic%20(general%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef85.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef85.jpg" alt="Figure 85. Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 85</span><span class="title">Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig86" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2086.%20Academic%20(general%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef86.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef86.jpg" alt="Figure 86. Academic (general, self, SRQ, 1-10, high is good, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 86</span><span class="title">Academic (general, self, SRQ, 1-10, high is good, PT <3 months)</span></h3></div><div id="ch6.appe.fig87" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2087.%20Academic%20(general%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef87.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef87.jpg" alt="Figure 87. Academic (general, self, SRQ, 1-10, high is good, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 87</span><span class="title">Academic (general, self, SRQ, 1-10, high is good, PT >3 months)</span></h3></div></div><div id="ch6.appe.s1.2.5"><h5>E.1.2.5. Stimulants + CBT versus CBT</h5><div id="ch6.appe.fig88" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2088.%20ADHD%20symptoms%20(total%2C%20observer%2C%20ADHD-RS%2C%200-68%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef88.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef88.jpg" alt="Figure 88. ADHD symptoms (total, observer, ADHD-RS, 0-68, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 88</span><span class="title">ADHD symptoms (total, observer, ADHD-RS, 0-68, high is poor, FV, PT, >3 months)</span></h3></div></div><div id="ch6.appe.s1.2.6"><h5>E.1.2.6. Mixed medication + PT/FT versus PT/FT</h5><div id="ch6.appe.fig89" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2089.%20ADHD%20symptoms%20(total%2C%20teacher%20and%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef89.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef89.jpg" alt="Figure 89. ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 89</span><span class="title">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig90" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2090.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef90.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef90.jpg" alt="Figure 90. ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 90</span><span class="title">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)</span></h3></div><div id="ch6.appe.fig91" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2091.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef91.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef91.jpg" alt="Figure 91. ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 91</span><span class="title">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig92" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2092.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef92.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef92.jpg" alt="Figure 92. ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 92</span><span class="title">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig93" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2093.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef93.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef93.jpg" alt="Figure 93. ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 93</span><span class="title">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig94" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2094.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef94.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef94.jpg" alt="Figure 94. ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 94</span><span class="title">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig95" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2095.%20Academic%20outcomes%20(maths%20accuracy%20%25%2C%20observer%2C%20high%20is%20better%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef95.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef95.jpg" alt="Figure 95. Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 95</span><span class="title">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)</span></h3></div><div id="ch6.appe.fig96" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2096.%20Academic%20outcomes%20(maths%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef96.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef96.jpg" alt="Figure 96. Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 96</span><span class="title">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</span></h3></div><div id="ch6.appe.fig97" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2097.%20Academic%20outcomes%20(reading%20accuracy%20%25%2C%20observer%2C%20high%20is%20better%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef97.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef97.jpg" alt="Figure 97. Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 97</span><span class="title">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)</span></h3></div><div id="ch6.appe.fig98" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2098.%20Academic%20outcomes%20(reading%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef98.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef98.jpg" alt="Figure 98. Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 98</span><span class="title">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</span></h3></div><div id="ch6.appe.fig99" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2099.%20Academic%20outcomes%20(reading%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef99.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef99.jpg" alt="Figure 99. Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 99</span><span class="title">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)</span></h3></div></div></div><div id="ch6.appe.s1.3"><h5>E.1.3. Combined treatment versus pharmacological treatment</h5><div id="ch6.appe.s1.3.1"><h5>E.1.3.1. Atomoxetine + parent/family training versus atomoxetine</h5><div id="ch6.appe.fig100" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20100.%20ADHD%20symptoms%20(total%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef100.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef100.jpg" alt="Figure 100. ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 100</span><span class="title">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig101" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20101.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef101.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef101.jpg" alt="Figure 101. ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 101</span><span class="title">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig102" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20102.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20multiple%20scales%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef102.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef102.jpg" alt="Figure 102. ADHD symptoms (hyperactivity, parent, multiple scales, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 102</span><span class="title">ADHD symptoms (hyperactivity, parent, multiple scales, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig103" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20103.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20multiple%20scales%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef103.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef103.jpg" alt="Figure 103. ADHD symptoms (hyperactivity, teacher, multiple scales, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 103</span><span class="title">ADHD symptoms (hyperactivity, teacher, multiple scales, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig104" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20104.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20multiple%20scales%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef104.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef104.jpg" alt="Figure 104. ADHD symptoms (inattention, parent, multiple scales, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 104</span><span class="title">ADHD symptoms (inattention, parent, multiple scales, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig105" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20105.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20multiple%20scales%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef105.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef105.jpg" alt="Figure 105. ADHD symptoms (inattention, teacher, multiple scales, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 105</span><span class="title">ADHD symptoms (inattention, teacher, multiple scales, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig106" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20106.%20Responders%20by%20CGI-I%20(PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef106.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef106.jpg" alt="Figure 106. Responders by CGI-I (PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 106</span><span class="title">Responders by CGI-I (PT, <3 months)</span></h3></div><div id="ch6.appe.fig107" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20107.%20Behaviour%2Ffunction%20(behaviour%2C%200-100%2C%20high%20is%20good%2C%20teacher%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef107.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef107.jpg" alt="Figure 107. Behaviour/function (behaviour, 0-100, high is good, teacher, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 107</span><span class="title">Behaviour/function (behaviour, 0-100, high is good, teacher, PT, <3 months)</span></h3></div></div><div id="ch6.appe.s1.3.2"><h5>E.1.3.2. Stimulants + PT/FT versus stimulants</h5><div id="ch6.appe.fig108" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20108.%20ADHD%20symptoms%20(total%2C%20parent%2C%20multiple%20scales%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef108.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef108.jpg" alt="Figure 108. ADHD symptoms (total, parent, multiple scales, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 108</span><span class="title">ADHD symptoms (total, parent, multiple scales, high is poor, FV, PT, >3 months)</span></h3></div><div id="ch6.appe.fig109" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20109.%20ADHD%20symptoms%20(total%2C%20parent%2C%20SWAN%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20FU%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef109.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef109.jpg" alt="Figure 109. ADHD symptoms (total, parent, SWAN, 0-3, high is poor, FV, FU, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 109</span><span class="title">ADHD symptoms (total, parent, SWAN, 0-3, high is poor, FV, FU, >3 months)</span></h3></div><div id="ch6.appe.fig110" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20110.%20symptoms%20(total%2C%20teacher%2C%20DBDRS%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef110.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef110.jpg" alt="Figure 110. symptoms (total, teacher, DBDRS, 0-54, high is poor, FV, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 110</span><span class="title">symptoms (total, teacher, DBDRS, 0-54, high is poor, FV, PT, <3 months)</span></h3></div><div id="ch6.appe.fig111" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20111.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20multiple%20scales%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef111.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef111.jpg" alt="Figure 111. ADHD symptoms (hyperactivity, parent, multiple scales, 0-3, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 111</span><span class="title">ADHD symptoms (hyperactivity, parent, multiple scales, 0-3, high is poor, FV, PT, >3 months)</span></h3></div><div id="ch6.appe.fig112" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20112.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef112.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef112.jpg" alt="Figure 112. ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 112</span><span class="title">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig113" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20113.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef113.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef113.jpg" alt="Figure 113. ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 113</span><span class="title">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig114" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20114.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef114.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef114.jpg" alt="Figure 114. ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 114</span><span class="title">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig115" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20115.%20symptoms%20(inattention%2C%20parent%2C%20FBB-ADHS%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef115.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef115.jpg" alt="Figure 115. symptoms (inattention, parent, FBB-ADHS, 0-3, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 115</span><span class="title">symptoms (inattention, parent, FBB-ADHS, 0-3, high is poor, FV, PT, >3 months)</span></h3></div><div id="ch6.appe.fig116" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20116.%20Behaviour%2Ffunction%20(function%2C%20parent%2C%20WFIRS-P%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef116.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef116.jpg" alt="Figure 116. Behaviour/function (function, parent, WFIRS-P, 0-3, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 116</span><span class="title">Behaviour/function (function, parent, WFIRS-P, 0-3, high is poor, FV, PT, >3 months)</span></h3></div></div><div id="ch6.appe.s1.3.3"><h5>E.1.3.3. Stimulants + PT/FT versus stimulants + NSST</h5><div id="ch6.appe.fig117" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20117.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef117.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef117.jpg" alt="Figure 117. ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 117</span><span class="title">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig118" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20118.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef118.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef118.jpg" alt="Figure 118. ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 118</span><span class="title">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig119" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20119.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef119.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef119.jpg" alt="Figure 119. ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 119</span><span class="title">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig120" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20120.%20symptoms%20(hyperactivity%2C%20teacher%2C%20CTRS%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef120.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef120.jpg" alt="Figure 120. symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 120</span><span class="title">symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)</span></h3></div></div><div id="ch6.appe.s1.3.4"><h5>E.1.3.4. Stimulants + attention/memory/cognitive training versus stimulants</h5><div id="ch6.appe.fig121" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20121.%20ADHD%20symptoms%20(total%2C%20parent%2C%20Conners%2048%2C%200-70%2C%20high%20is%20poor%2C%20FV%2C%20%3C3%20months%20PT).&p=BOOKS&id=578099_ch6appef121.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef121.jpg" alt="Figure 121. ADHD symptoms (total, parent, Conners 48, 0-70, high is poor, FV, <3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 121</span><span class="title">ADHD symptoms (total, parent, Conners 48, 0-70, high is poor, FV, <3 months PT)</span></h3></div></div><div id="ch6.appe.s1.3.5"><h5>E.1.3.5. Stimulants + NF versus stimulants</h5><div id="ch6.appe.fig122" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20122.%20ADHD%20symptoms%20(total%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef122.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef122.jpg" alt="Figure 122. ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 122</span><span class="title">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig123" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20123.%20ADHD%20symptoms%20(total%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef123.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef123.jpg" alt="Figure 123. ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 123</span><span class="title">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig124" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20124.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef124.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef124.jpg" alt="Figure 124. ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 124</span><span class="title">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig125" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20125.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef125.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef125.jpg" alt="Figure 125. ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 125</span><span class="title">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig126" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20126.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef126.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef126.jpg" alt="Figure 126. ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 126</span><span class="title">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig127" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20127.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef127.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef127.jpg" alt="Figure 127. ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 127</span><span class="title">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig128" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20128.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef128.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef128.jpg" alt="Figure 128. ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 128</span><span class="title">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig129" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20129.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef129.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef129.jpg" alt="Figure 129. ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 129</span><span class="title">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig130" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20130.%20ADHD%20symptoms%20(hyperactivity%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef130.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef130.jpg" alt="Figure 130. ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 130</span><span class="title">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, <3 months)</span></h3></div><div id="ch6.appe.fig131" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20131.%20ADHD%20symptoms%20(hyperactivity%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef131.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef131.jpg" alt="Figure 131. ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 131</span><span class="title">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, >3 months)</span></h3></div><div id="ch6.appe.fig132" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20132.%20ADHD%20symptoms%20(hyperactivity%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef132.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef132.jpg" alt="Figure 132. ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 132</span><span class="title">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig133" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20133.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef133.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef133.jpg" alt="Figure 133. ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 133</span><span class="title">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig134" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20134.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef134.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef134.jpg" alt="Figure 134. ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 134</span><span class="title">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig135" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20135.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef135.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef135.jpg" alt="Figure 135. ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 135</span><span class="title">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</span></h3></div><div id="ch6.appe.fig136" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20136.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20Barkley%02019s%2C%200-54%2C%20high%20is%20poor%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef136.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef136.jpg" alt="Figure 136. ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 136</span><span class="title">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months)</span></h3></div><div id="ch6.appe.fig137" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20137.%20ADHD%20symptoms%20(inattention%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef137.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef137.jpg" alt="Figure 137. ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 137</span><span class="title">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, <3 months)</span></h3></div><div id="ch6.appe.fig138" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20138.%20symptoms%20(inattention%2C%20self-rated%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef138.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef138.jpg" alt="Figure 138. symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 138</span><span class="title">symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, >3 months)</span></h3></div><div id="ch6.appe.fig139" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20139.%20ADHD%20symptoms%20(inattention%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef139.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef139.jpg" alt="Figure 139. ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 139</span><span class="title">ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig140" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20140.%20Academic%20(general%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef140.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef140.jpg" alt="Figure 140. Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 140</span><span class="title">Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig141" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20141.%20Academic%20(general%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef141.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef141.jpg" alt="Figure 141. Academic (general, self, SRQ, 1-10, high is good, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 141</span><span class="title">Academic (general, self, SRQ, 1-10, high is good, PT <3 months)</span></h3></div><div id="ch6.appe.fig142" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20142.%20Academic%20(general%2C%20self%2C%20SRQ%2C%201-10%2C%20high%20is%20good%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef142.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef142.jpg" alt="Figure 142. Academic (general, self, SRQ, 1-10, high is good, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 142</span><span class="title">Academic (general, self, SRQ, 1-10, high is good, PT >3 months)</span></h3></div></div><div id="ch6.appe.s1.3.6"><h5>E.1.3.6. Mixed medication + PT/FT versus mixed medication</h5><div id="ch6.appe.fig143" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20143.%20ADHD%20symptoms%20(total%2C%20parent%2C%20ADHD-RS-IV%2C0-54%2C%20high%20is%20poor%2C%20CS%2C%20FU%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef143.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef143.jpg" alt="Figure 143. ADHD symptoms (total, parent, ADHD-RS-IV,0-54, high is poor, CS, FU, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 143</span><span class="title">ADHD symptoms (total, parent, ADHD-RS-IV,0-54, high is poor, CS, FU, >3 months)</span></h3></div><div id="ch6.appe.fig144" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20144.%20symptoms%20(total%2C%20teacher%20and%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef144.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef144.jpg" alt="Figure 144. symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 144</span><span class="title">symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig145" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20145.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20Conner%02019s%2C%200-20%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef145.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef145.jpg" alt="Figure 145. ADHD symptoms (hyperactivity, teacher, Conner’s, 0-20, high is poor, FV, PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 145</span><span class="title">ADHD symptoms (hyperactivity, teacher, Conner’s, 0-20, high is poor, FV, PT, <3 months)</span></h3></div><div id="ch6.appe.fig146" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20146.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20multiple%20scales%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef146.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef146.jpg" alt="Figure 146. ADHD symptoms (hyperactivity, teacher, multiple scales, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 146</span><span class="title">ADHD symptoms (hyperactivity, teacher, multiple scales, high is poor, FV, PT, >3 months)</span></h3></div><div id="ch6.appe.fig147" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20147.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef147.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef147.jpg" alt="Figure 147. ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 147</span><span class="title">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig148" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20148.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef148.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef148.jpg" alt="Figure 148. ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 148</span><span class="title">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig149" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20149.%20symptoms%20(hyperactivity%2C%20parent%2C%20ADHD-RS-IV%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20FU%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef149.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef149.jpg" alt="Figure 149. symptoms (hyperactivity, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 149</span><span class="title">symptoms (hyperactivity, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months)</span></h3></div><div id="ch6.appe.fig150" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20150.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef150.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef150.jpg" alt="Figure 150. ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 150</span><span class="title">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig151" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20151.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef151.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef151.jpg" alt="Figure 151. ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 151</span><span class="title">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig152" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20152.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20ADHD-RS-IV%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20FU%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef152.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef152.jpg" alt="Figure 152. ADHD symptoms (inattention, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 152</span><span class="title">ADHD symptoms (inattention, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months)</span></h3></div><div id="ch6.appe.fig153" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20153.%20Behaviour%2Ffunction%20(CBRS%20aggressive%20behaviour%20subscale%2C%200-15%2C%20high%20is%20poor%2C%20teacher%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef153.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef153.jpg" alt="Figure 153. Behaviour/function (CBRS aggressive behaviour subscale, 0-15, high is poor, teacher, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 153</span><span class="title">Behaviour/function (CBRS aggressive behaviour subscale, 0-15, high is poor, teacher, PT <3 months)</span></h3></div><div id="ch6.appe.fig154" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20154.%20Behaviour%2Ffunction%20(CBRS%20aggressive%20behaviour%20subscale%2C%200-15%2C%20high%20is%20poor%2C%20teacher%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef154.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef154.jpg" alt="Figure 154. Behaviour/function (CBRS aggressive behaviour subscale, 0-15, high is poor, teacher, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 154</span><span class="title">Behaviour/function (CBRS aggressive behaviour subscale, 0-15, high is poor, teacher, PT >3 months)</span></h3></div><div id="ch6.appe.fig155" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20155.%20Emotional%20dysregulation%20(CBRS%20emotional%20distress%20subscale%2C%200-20%2C%20high%20is%20poor%2C%20teacher%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef155.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef155.jpg" alt="Figure 155. Emotional dysregulation (CBRS emotional distress subscale, 0-20, high is poor, teacher, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 155</span><span class="title">Emotional dysregulation (CBRS emotional distress subscale, 0-20, high is poor, teacher, PT <3 months)</span></h3></div><div id="ch6.appe.fig156" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20156.%20Emotional%20dysregulation%20(CBRS%20emotional%20distress%20subscale%2C%200-20%2C%20high%20is%20poor%2C%20teacher%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef156.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef156.jpg" alt="Figure 156. Emotional dysregulation (CBRS emotional distress subscale, 0-20, high is poor, teacher, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 156</span><span class="title">Emotional dysregulation (CBRS emotional distress subscale, 0-20, high is poor, teacher, PT >3 months)</span></h3></div><div id="ch6.appe.fig157" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20157.%20Academic%20outcomes%20(maths%20accuracy%20%25%2C%20observer%2C%20high%20is%20better%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef157.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef157.jpg" alt="Figure 157. Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 157</span><span class="title">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)</span></h3></div><div id="ch6.appe.fig158" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20158.%20Academic%20outcomes%20(maths%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef158.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef158.jpg" alt="Figure 158. Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 158</span><span class="title">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</span></h3></div><div id="ch6.appe.fig159" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20159.%20Academic%20outcomes%20(reading%20accuracy%20%25%2C%20observer%2C%20high%20is%20better%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef159.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef159.jpg" alt="Figure 159. Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 159</span><span class="title">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)</span></h3></div><div id="ch6.appe.fig160" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20160.%20Academic%20outcomes%20(reading%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef160.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef160.jpg" alt="Figure 160. Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 160</span><span class="title">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</span></h3></div><div id="ch6.appe.fig161" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20161.%20Academic%20outcomes%20(reading%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef161.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef161.jpg" alt="Figure 161. Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 161</span><span class="title">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)</span></h3></div><div id="ch6.appe.fig162" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20162.%20Academic%20outcomes%20(general%2C%20CBRS%20academic%20subscale%2C%200-30%2C%20high%20is%20poor%2C%20teacher%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef162.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef162.jpg" alt="Figure 162. Academic outcomes (general, CBRS academic subscale, 0-30, high is poor, teacher, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 162</span><span class="title">Academic outcomes (general, CBRS academic subscale, 0-30, high is poor, teacher, PT <3 months)</span></h3></div><div id="ch6.appe.fig163" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20163.%20Academic%20outcomes%20(general%2C%20CBRS%20academic%20subscale%2C%200-30%2C%20high%20is%20poor%2C%20teacher%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef163.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef163.jpg" alt="Figure 163. Academic outcomes (general, CBRS academic subscale, 0-30, high is poor, teacher, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 163</span><span class="title">Academic outcomes (general, CBRS academic subscale, 0-30, high is poor, teacher, PT >3 months)</span></h3></div></div><div id="ch6.appe.s1.3.7"><h5>E.1.3.7. Mixed medication + CBT versus mixed medication</h5><div id="ch6.appe.fig164" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20164.%20ADHD%20symptoms%20(total%2C%20self%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef164.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef164.jpg" alt="Figure 164. ADHD symptoms (total, self, ADHD-RS, 0-54, high is poor, CS, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 164</span><span class="title">ADHD symptoms (total, self, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</span></h3></div><div id="ch6.appe.fig165" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20165.%20ADHD%20symptoms%20(total%2C%20self%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef165.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef165.jpg" alt="Figure 165. ADHD symptoms (total, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 165</span><span class="title">ADHD symptoms (total, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig166" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20166.%20ADHD%20symptoms%20(total%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef166.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef166.jpg" alt="Figure 166. ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 166</span><span class="title">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig167" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20167.%20ADHD%20symptoms%20(total%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef167.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef167.jpg" alt="Figure 167. ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 167</span><span class="title">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</span></h3></div><div id="ch6.appe.fig168" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20168.%20ADHD%20symptoms%20(hyperactivity%2C%20self%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef168.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef168.jpg" alt="Figure 168. ADHD symptoms (hyperactivity, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 168</span><span class="title">ADHD symptoms (hyperactivity, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig169" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20169.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef169.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef169.jpg" alt="Figure 169. ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 169</span><span class="title">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig170" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20170.%20ADHD%20symptoms%20(inattention%2C%20self%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef170.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef170.jpg" alt="Figure 170. ADHD symptoms (inattention, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 170</span><span class="title">ADHD symptoms (inattention, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig171" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20171.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef171.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef171.jpg" alt="Figure 171. ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 171</span><span class="title">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</span></h3></div></div><div id="ch6.appe.s1.3.8"><h5>E.1.3.8. Mixed medication + PE versus mixed medication + NSST</h5><div id="ch6.appe.fig172" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20172.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20CPRS%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef172.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef172.jpg" alt="Figure 172. ADHD symptoms (hyperactivity, parent, CPRS, 0-27, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 172</span><span class="title">ADHD symptoms (hyperactivity, parent, CPRS, 0-27, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig173" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20173.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20CPRS%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef173.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef173.jpg" alt="Figure 173. ADHD symptoms (hyperactivity, parent, CPRS, 0-27, high is poor, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 173</span><span class="title">ADHD symptoms (hyperactivity, parent, CPRS, 0-27, high is poor, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig174" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20174.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20CPRS%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef174.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef174.jpg" alt="Figure 174. ADHD symptoms (inattention, parent, CPRS, 0-27, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 174</span><span class="title">ADHD symptoms (inattention, parent, CPRS, 0-27, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig175" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20175.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20CPRS%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef175.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef175.jpg" alt="Figure 175. ADHD symptoms (inattention, parent, CPRS, 0-27, high is poor, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 175</span><span class="title">ADHD symptoms (inattention, parent, CPRS, 0-27, high is poor, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig176" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20176.%20Behaviour%2Ffunction%20(opposition%2C%20parent%2C%20CPRS%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef176.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef176.jpg" alt="Figure 176. Behaviour/function (opposition, parent, CPRS, 0-27, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 176</span><span class="title">Behaviour/function (opposition, parent, CPRS, 0-27, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig177" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20177.%20Behaviour%2Ffunction%20(opposition%2C%20parent%2C%20CPRS%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef177.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef177.jpg" alt="Figure 177. Behaviour/function (opposition, parent, CPRS, 0-27, high is poor, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 177</span><span class="title">Behaviour/function (opposition, parent, CPRS, 0-27, high is poor, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig178" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20178.%20Emotional%20dysregulation%20(SDQ%2C%20parent%2C%200-25%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef178.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef178.jpg" alt="Figure 178. Emotional dysregulation (SDQ, parent, 0-25, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 178</span><span class="title">Emotional dysregulation (SDQ, parent, 0-25, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig179" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20179.%20Emotional%20dysregulation%20(SDQ%2C%20parent%2C%200-25%2C%20high%20is%20poor%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef179.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef179.jpg" alt="Figure 179. Emotional dysregulation (SDQ, parent, 0-25, high is poor, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 179</span><span class="title">Emotional dysregulation (SDQ, parent, 0-25, high is poor, FV, FU >3 months)</span></h3></div></div><div id="ch6.appe.s1.3.9"><h5>E.1.3.9. Mixed medication + sleep intervention versus mixed medication</h5><div id="ch6.appe.fig180" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20180.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef180.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef180.jpg" alt="Figure 180. ADHD symptoms (total, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 180</span><span class="title">ADHD symptoms (total, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig181" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20181.%20ADHD%20symptoms%20(total%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef181.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef181.jpg" alt="Figure 181. ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 181</span><span class="title">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig182" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20182.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef182.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef182.jpg" alt="Figure 182. ADHD symptoms (total, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 182</span><span class="title">ADHD symptoms (total, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</span></h3></div><div id="ch6.appe.fig183" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20183.%20ADHD%20symptoms%20(total%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef183.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef183.jpg" alt="Figure 183. ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 183</span><span class="title">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</span></h3></div><div id="ch6.appe.fig184" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20184.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef184.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef184.jpg" alt="Figure 184. ADHD symptoms (hyperactivity, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 184</span><span class="title">ADHD symptoms (hyperactivity, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig185" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20185.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef185.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef185.jpg" alt="Figure 185. ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 185</span><span class="title">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig186" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20186.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef186.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef186.jpg" alt="Figure 186. ADHD symptoms (hyperactivity, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 186</span><span class="title">ADHD symptoms (hyperactivity, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</span></h3></div><div id="ch6.appe.fig187" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20187.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef187.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef187.jpg" alt="Figure 187. ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 187</span><span class="title">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</span></h3></div><div id="ch6.appe.fig188" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20188.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef188.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef188.jpg" alt="Figure 188. ADHD symptoms (inattention, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 188</span><span class="title">ADHD symptoms (inattention, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig189" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20189.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef189.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef189.jpg" alt="Figure 189. ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 189</span><span class="title">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</span></h3></div><div id="ch6.appe.fig190" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20190.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef190.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef190.jpg" alt="Figure 190. ADHD symptoms (inattention, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 190</span><span class="title">ADHD symptoms (inattention, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</span></h3></div><div id="ch6.appe.fig191" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20191.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef191.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef191.jpg" alt="Figure 191. ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 191</span><span class="title">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</span></h3></div><div id="ch6.appe.fig192" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20192.%20Behaviour%2Ffunction%20(teacher%2C%20SDQ%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20%3C3%20months%20PT.&p=BOOKS&id=578099_ch6appef192.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef192.jpg" alt="Figure 192. Behaviour/function (teacher, SDQ, 0-54, high is poor, CS, <3 months PT." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 192</span><span class="title">Behaviour/function (teacher, SDQ, 0-54, high is poor, CS, <3 months PT</span></h3></div><div id="ch6.appe.fig193" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20193.%20Behaviour%2Ffunction%20(teacher%2C%20SDQ%2C%200-54%2C%20high%20is%20poor%2C%20CS%2C%20%3E3%20months%20PT.&p=BOOKS&id=578099_ch6appef193.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef193.jpg" alt="Figure 193. Behaviour/function (teacher, SDQ, 0-54, high is poor, CS, >3 months PT." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 193</span><span class="title">Behaviour/function (teacher, SDQ, 0-54, high is poor, CS, >3 months PT</span></h3></div></div><div id="ch6.appe.s1.3.10"><h5>E.1.3.10. Mixed medication + NF versus mixed medication</h5><div id="ch6.appe.fig194" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20194.%20ADHD%20symptoms%20(total%2C%20parent%2C%20ADHD-RS%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef194.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef194.jpg" alt="Figure 194. ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 194</span><span class="title">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig195" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20195.%20Behaviour%2Ffunction%20(CBRS%2C%20parent%2C%20unclear%20scale%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef195.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef195.jpg" alt="Figure 195. Behaviour/function (CBRS, parent, unclear scale, high is poor, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 195</span><span class="title">Behaviour/function (CBRS, parent, unclear scale, high is poor, FV, PT <3 months)</span></h3></div></div></div><div id="ch6.appe.s1.4"><h5>E.1.4. Combined treatment versus no treatment/usual care</h5><div id="ch6.appe.s1.4.1"><h5>E.1.4.1. Atomoxetine + PT/FT versus placebo</h5><div id="ch6.appe.fig196" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20196.%20ADHD%20symptoms%20(total%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef196.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef196.jpg" alt="Figure 196. ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 196</span><span class="title">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig197" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20197.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef197.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef197.jpg" alt="Figure 197. ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 197</span><span class="title">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig198" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20198.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef198.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef198.jpg" alt="Figure 198. ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 198</span><span class="title">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig199" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20199.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef199.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef199.jpg" alt="Figure 199. ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 199</span><span class="title">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig200" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20200.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef200.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef200.jpg" alt="Figure 200. ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 200</span><span class="title">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig201" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20201.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SNAP%2C%200-3%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef201.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef201.jpg" alt="Figure 201. ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 201</span><span class="title">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig202" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20202.%20Responders%20by%20CGI-I%20(PT%2C%20%3C3%20months).&p=BOOKS&id=578099_ch6appef202.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef202.jpg" alt="Figure 202. Responders by CGI-I (PT, <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 202</span><span class="title">Responders by CGI-I (PT, <3 months)</span></h3></div></div><div id="ch6.appe.s1.4.2"><h5>E.1.4.2. Mixed medication + PT/FT versus usual care</h5><div id="ch6.appe.fig203" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20203.%20ADHD%20symptoms%20(total%2C%20teacher%20and%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef203.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef203.jpg" alt="Figure 203. ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 203</span><span class="title">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig204" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20204.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%2C%20%3E3%20months).&p=BOOKS&id=578099_ch6appef204.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef204.jpg" alt="Figure 204. ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 204</span><span class="title">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)</span></h3></div><div id="ch6.appe.fig205" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20205.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef205.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef205.jpg" alt="Figure 205. ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 205</span><span class="title">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig206" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20206.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef206.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef206.jpg" alt="Figure 206. ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 206</span><span class="title">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig207" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20207.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef207.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef207.jpg" alt="Figure 207. ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 207</span><span class="title">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig208" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20208.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20SNAP%2C%200-3%2C%20high%20is%20poor%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef208.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef208.jpg" alt="Figure 208. ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 208</span><span class="title">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig209" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20209.%20Academic%20outcomes%20(maths%20accuracy%20%25%2C%20observer%2C%20high%20is%20better%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef209.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef209.jpg" alt="Figure 209. Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 209</span><span class="title">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)</span></h3></div><div id="ch6.appe.fig210" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20210.%20Academic%20outcomes%20(maths%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef210.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef210.jpg" alt="Figure 210. Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 210</span><span class="title">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</span></h3></div><div id="ch6.appe.fig211" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20211.%20Academic%20outcomes%20(reading%20accuracy%20%25%2C%20observer%2C%20high%20is%20better%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef211.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef211.jpg" alt="Figure 211. Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 211</span><span class="title">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)</span></h3></div><div id="ch6.appe.fig212" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20212.%20Academic%20outcomes%20(reading%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef212.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef212.jpg" alt="Figure 212. Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 212</span><span class="title">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</span></h3></div><div id="ch6.appe.fig213" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20213.%20Academic%20outcomes%20(reading%20accuracy%2C%20observer%2C%20WIAT%2C%200-132%2C%20high%20is%20better%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef213.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef213.jpg" alt="Figure 213. Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 213</span><span class="title">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)</span></h3></div></div></div><div id="ch6.appe.s1.5"><h5>E.1.5. Combined treatment versus other combined treatment</h5><div id="ch6.appe.s1.5.1"><h5>E.1.5.1. Stimulants + NF versus stimulants + attention/memory/cognitive training</h5><div id="ch6.appe.fig214" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20214.%20ADHD%20symptoms%20(total%2C%20parent%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef214.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef214.jpg" alt="Figure 214. ADHD symptoms (total, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 214</span><span class="title">ADHD symptoms (total, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig215" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20215.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef215.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef215.jpg" alt="Figure 215. ADHD symptoms (total, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 215</span><span class="title">ADHD symptoms (total, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig216" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20216.%20ADHD%20symptoms%20(total%2C%20parent%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef216.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef216.jpg" alt="Figure 216. ADHD symptoms (total, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 216</span><span class="title">ADHD symptoms (total, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig217" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20217.%20ADHD%20symptoms%20(total%2C%20teacher%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef217.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef217.jpg" alt="Figure 217. ADHD symptoms (total, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 217</span><span class="title">ADHD symptoms (total, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig218" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20218.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef218.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef218.jpg" alt="Figure 218. ADHD symptoms (hyperactivity, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 218</span><span class="title">ADHD symptoms (hyperactivity, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig219" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20219.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef219.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef219.jpg" alt="Figure 219. ADHD symptoms (hyperactivity, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 219</span><span class="title">ADHD symptoms (hyperactivity, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig220" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20220.%20ADHD%20symptoms%20(hyperactivity%2C%20parent%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef220.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef220.jpg" alt="Figure 220. ADHD symptoms (hyperactivity, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 220</span><span class="title">ADHD symptoms (hyperactivity, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig221" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20221.%20ADHD%20symptoms%20(hyperactivity%2C%20teacher%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef221.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef221.jpg" alt="Figure 221. ADHD symptoms (hyperactivity, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 221</span><span class="title">ADHD symptoms (hyperactivity, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig222" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20222.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef222.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef222.jpg" alt="Figure 222. ADHD symptoms (inattention, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 222</span><span class="title">ADHD symptoms (inattention, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig223" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20223.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20PT%20%3C3%20months).&p=BOOKS&id=578099_ch6appef223.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef223.jpg" alt="Figure 223. ADHD symptoms (inattention, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 223</span><span class="title">ADHD symptoms (inattention, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</span></h3></div><div id="ch6.appe.fig224" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20224.%20ADHD%20symptoms%20(inattention%2C%20parent%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef224.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef224.jpg" alt="Figure 224. ADHD symptoms (inattention, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 224</span><span class="title">ADHD symptoms (inattention, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</span></h3></div><div id="ch6.appe.fig225" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20225.%20ADHD%20symptoms%20(inattention%2C%20teacher%2C%20DSM-IV%2C%20high%20is%20poor%2C%20unclear%20scale%2C%20FV%2C%20FU%20%3E3%20months).&p=BOOKS&id=578099_ch6appef225.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef225.jpg" alt="Figure 225. ADHD symptoms (inattention, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 225</span><span class="title">ADHD symptoms (inattention, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</span></h3></div></div></div></div><div id="ch6.appe.s2"><h4>E.2. Adults over the age of 18</h4><div id="ch6.appe.s2.1"><h5>E.2.1. Pharmacological treatment versus non-pharmacological treatment</h5><div id="ch6.appe.s2.1.1"><h5>E.2.1.1. Stimulants + NSST versus CBT alone</h5><div id="ch6.appe.fig226" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20226.%20ADHD%20symptoms%20(total%2C%20self%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef226.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef226.jpg" alt="Figure 226. ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 226</span><span class="title">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig227" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20227.%20ADHD%20symptoms%20(total%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef227.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef227.jpg" alt="Figure 227. ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 227</span><span class="title">ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig228" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20228.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef228.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef228.jpg" alt="Figure 228. ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 228</span><span class="title">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig229" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20229.%20ADHD%20symptoms%20(inattention%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef229.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef229.jpg" alt="Figure 229. ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 229</span><span class="title">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig230" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20230.%20Emotional%20dysregulation%20(Self%2C%20BDI%2C%200-63%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef230.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef230.jpg" alt="Figure 230. Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 230</span><span class="title">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)</span></h3></div></div></div><div id="ch6.appe.s2.2"><h5>E.2.2. Combined treatment versus non-pharmacological treatment</h5><div id="ch6.appe.s2.2.1"><h5>E.2.2.1. Stimulants + CBT/DBT versus CBT/DBT alone</h5><div id="ch6.appe.fig231" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20231.%20ADHD%20symptoms%20(total%2C%20self%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef231.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef231.jpg" alt="Figure 231. ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 231</span><span class="title">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig232" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20232.%20ADHD%20symptoms%20(total%2C%20self%2C%20multiple%20tools%2C%20decreased%20by%20%3E30%25%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef232.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef232.jpg" alt="Figure 232. ADHD symptoms (total, self, multiple tools, decreased by >30%, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 232</span><span class="title">ADHD symptoms (total, self, multiple tools, decreased by >30%, >3 months PT)</span></h3></div><div id="ch6.appe.fig233" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20233.%20ADHD%20symptoms%20(total%2C%20observer%2C%20TAADDS%2C%20decreased%20by%20%3E30%25%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef233.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef233.jpg" alt="Figure 233. ADHD symptoms (total, observer, TAADDS, decreased by >30%, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 233</span><span class="title">ADHD symptoms (total, observer, TAADDS, decreased by >30%, >3 months PT)</span></h3></div><div id="ch6.appe.fig234" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20234.%20ADHD%20symptoms%20(total%2C%20observer%2C%20multiple%20tools%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef234.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef234.jpg" alt="Figure 234. ADHD symptoms (total, observer, multiple tools, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 234</span><span class="title">ADHD symptoms (total, observer, multiple tools, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig235" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20235.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef235.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef235.jpg" alt="Figure 235. ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 235</span><span class="title">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig236" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20236.%20symptoms%20(inattention%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef236.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef236.jpg" alt="Figure 236. symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 236</span><span class="title">symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig237" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20237.%20Emotional%20dysregulation%20(multiple%20tools%2C%200-15%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef237.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef237.jpg" alt="Figure 237. Emotional dysregulation (multiple tools, 0-15, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 237</span><span class="title">Emotional dysregulation (multiple tools, 0-15, high is poor, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig238" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20238.%20Responders%20by%20CGI-I%20(%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef238.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef238.jpg" alt="Figure 238. Responders by CGI-I (>3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 238</span><span class="title">Responders by CGI-I (>3 months PT)</span></h3></div><div id="ch6.appe.fig239" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20239.%20Responders%20by%20CGI-I%20(%3E3%20months%20FU).&p=BOOKS&id=578099_ch6appef239.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef239.jpg" alt="Figure 239. Responders by CGI-I (>3 months FU)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 239</span><span class="title">Responders by CGI-I (>3 months FU)</span></h3></div></div><div id="ch6.appe.s2.2.2"><h5>E.2.2.2. Stimulants + CBT/DBT + PT/FT versus NSST + PT/FT</h5><div id="ch6.appe.fig240" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20240.%20ADHD%20symptoms%20(total%2C%20observer%2C%20CAARS%2C%200-36%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef240.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef240.jpg" alt="Figure 240. ADHD symptoms (total, observer, CAARS, 0-36, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 240</span><span class="title">ADHD symptoms (total, observer, CAARS, 0-36, high is poor, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig241" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20241.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20CAARS%2C%200-36%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef241.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef241.jpg" alt="Figure 241. ADHD symptoms (hyperactivity, observer, CAARS, 0-36, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 241</span><span class="title">ADHD symptoms (hyperactivity, observer, CAARS, 0-36, high is poor, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig242" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20242.%20ADHD%20symptoms%20(inattention%2C%20observer%2C%20CAARS%2C%200-36%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef242.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef242.jpg" alt="Figure 242. ADHD symptoms (inattention, observer, CAARS, 0-36, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 242</span><span class="title">ADHD symptoms (inattention, observer, CAARS, 0-36, high is poor, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig243" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20243.%20Child%02019s%20ADHD%20symptoms%20(total%2C%20parent%2C%20SDQ%2C%200-10%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef243.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef243.jpg" alt="Figure 243. Child’s ADHD symptoms (total, parent, SDQ, 0-10, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 243</span><span class="title">Child’s ADHD symptoms (total, parent, SDQ, 0-10, high is poor, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig244" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20244.%20Emotional%20dysregulation%20(parent%2C%20SDQ%2C%200-10%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef244.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef244.jpg" alt="Figure 244. Emotional dysregulation (parent, SDQ, 0-10, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 244</span><span class="title">Emotional dysregulation (parent, SDQ, 0-10, high is poor, FV, >3 months PT)</span></h3></div></div></div><div id="ch6.appe.s2.3"><h5>E.2.3. Combined treatment versus pharmacological treatment</h5><div id="ch6.appe.s2.3.1"><h5>E.2.3.1. Stimulants + CBT/DBT versus stimulants + NSST</h5><div id="ch6.appe.fig245" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20245.%20ADHD%20symptoms%20(total%2C%20self%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef245.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef245.jpg" alt="Figure 245. ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 245</span><span class="title">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig246" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20246.%20symptoms%20(total%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef246.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef246.jpg" alt="Figure 246. symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 246</span><span class="title">symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig247" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20247.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef247.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef247.jpg" alt="Figure 247. ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 247</span><span class="title">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig248" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20248.%20ADHD%20symptoms%20(inattention%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef248.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef248.jpg" alt="Figure 248. ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 248</span><span class="title">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig249" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20249.%20Emotional%20dysregulation%20(Self%2C%20BDI%2C%200-63%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef249.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef249.jpg" alt="Figure 249. Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 249</span><span class="title">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)</span></h3></div></div><div id="ch6.appe.s2.3.2"><h5>E.2.3.2. Mixed medication + CBT/DBT versus mixed medication alone</h5><div id="ch6.appe.fig250" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20250.%20QoL%20(Flanagan%2C%2016-112%2C%20high%20is%20good%2C%20FV%2C%20%3C3%20months%20PT).&p=BOOKS&id=578099_ch6appef250.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef250.jpg" alt="Figure 250. QoL (Flanagan, 16-112, high is good, FV, <3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 250</span><span class="title">QoL (Flanagan, 16-112, high is good, FV, <3 months PT)</span></h3></div><div id="ch6.appe.fig251" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20251.%20QoL%20(Flanagan%2C%2016-112%2C%20high%20is%20good%2C%20FV%2C%20%3C3%20months%20FU).&p=BOOKS&id=578099_ch6appef251.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef251.jpg" alt="Figure 251. QoL (Flanagan, 16-112, high is good, FV, <3 months FU)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 251</span><span class="title">QoL (Flanagan, 16-112, high is good, FV, <3 months FU)</span></h3></div><div id="ch6.appe.fig252" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20252.%20ADHD%20symptoms%20(total%2C%20observer%2C%20ADHD-RS%2C%200-54%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef252.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef252.jpg" alt="Figure 252. ADHD symptoms (total, observer, ADHD-RS, 0-54, higher is worse, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 252</span><span class="title">ADHD symptoms (total, observer, ADHD-RS, 0-54, higher is worse, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig253" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20253.%20ADHD%20symptoms%20(total%2C%20self%2C%20ADHD-RS%2C%200-54%2C%20higher%20is%20worse%2C%20FV%2C%20PT%20%3E3%20months).&p=BOOKS&id=578099_ch6appef253.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef253.jpg" alt="Figure 253. ADHD symptoms (total, self, ADHD-RS, 0-54, higher is worse, FV, PT >3 months)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 253</span><span class="title">ADHD symptoms (total, self, ADHD-RS, 0-54, higher is worse, FV, PT >3 months)</span></h3></div><div id="ch6.appe.fig254" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20254.%20ADHD%20symptoms%20(total%2C%20self%2C%20Barkley%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20%3C3%20months%20PT).&p=BOOKS&id=578099_ch6appef254.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef254.jpg" alt="Figure 254. ADHD symptoms (total, self, Barkley, 0-54, high is poor, FV, <3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 254</span><span class="title">ADHD symptoms (total, self, Barkley, 0-54, high is poor, FV, <3 months PT)</span></h3></div><div id="ch6.appe.fig255" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20255.%20ADHD%20symptoms%20(total%2C%20self%2C%20Barkley%2C%200-54%2C%20high%20is%20poor%2C%20FV%2C%20%3C3%20months%20FU).&p=BOOKS&id=578099_ch6appef255.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef255.jpg" alt="Figure 255. ADHD symptoms (total, self, Barkley, 0-54, high is poor, FV, <3 months FU)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 255</span><span class="title">ADHD symptoms (total, self, Barkley, 0-54, high is poor, FV, <3 months FU)</span></h3></div><div id="ch6.appe.fig256" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20256.%20ADHD%20symptoms%20(hyperactivity%2C%20self%2C%20Barkley%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20%3C3%20months%20PT).&p=BOOKS&id=578099_ch6appef256.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef256.jpg" alt="Figure 256. ADHD symptoms (hyperactivity, self, Barkley, 0-27, high is poor, FV, <3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 256</span><span class="title">ADHD symptoms (hyperactivity, self, Barkley, 0-27, high is poor, FV, <3 months PT)</span></h3></div><div id="ch6.appe.fig257" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20257.%20ADHD%20symptoms%20(hyperactivity%2C%20self%2C%20Barkley%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20%3C3%20months%20FU).&p=BOOKS&id=578099_ch6appef257.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef257.jpg" alt="Figure 257. ADHD symptoms (hyperactivity, self, Barkley, 0-27, high is poor, FV, <3 months FU)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 257</span><span class="title">ADHD symptoms (hyperactivity, self, Barkley, 0-27, high is poor, FV, <3 months FU)</span></h3></div><div id="ch6.appe.fig258" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20258.%20symptoms%20(inattention%2C%20self%2C%20Barkley%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20%3C3%20months%20PT).&p=BOOKS&id=578099_ch6appef258.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef258.jpg" alt="Figure 258. symptoms (inattention, self, Barkley, 0-27, high is poor, FV, <3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 258</span><span class="title">symptoms (inattention, self, Barkley, 0-27, high is poor, FV, <3 months PT)</span></h3></div><div id="ch6.appe.fig259" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20259.%20ADHD%20symptoms%20(inattention%2C%20self%2C%20Barkley%2C%200-27%2C%20high%20is%20poor%2C%20FV%2C%20%3C3%20months%20FU).&p=BOOKS&id=578099_ch6appef259.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef259.jpg" alt="Figure 259. ADHD symptoms (inattention, self, Barkley, 0-27, high is poor, FV, <3 months FU)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 259</span><span class="title">ADHD symptoms (inattention, self, Barkley, 0-27, high is poor, FV, <3 months FU)</span></h3></div><div id="ch6.appe.fig260" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20260.%20Responders%20by%20CGI.&p=BOOKS&id=578099_ch6appef260.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef260.jpg" alt="Figure 260. Responders by CGI." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 260</span><span class="title">Responders by CGI</span></h3></div><div id="ch6.appe.fig261" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20261.%20Emotional%20dysregulation%20(HAM-D%2C%20observer%2C%200-53%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef261.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef261.jpg" alt="Figure 261. Emotional dysregulation (HAM-D, observer, 0-53, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 261</span><span class="title">Emotional dysregulation (HAM-D, observer, 0-53, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig262" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20262.%20Emotional%20dysregulation%20(Self%2C%20BDI%2C%200-64%2C%20high%20is%20worse%2C%20FV%2C%20%3C3%20months%20PT).&p=BOOKS&id=578099_ch6appef262.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef262.jpg" alt="Figure 262. Emotional dysregulation (Self, BDI, 0-64, high is worse, FV, <3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 262</span><span class="title">Emotional dysregulation (Self, BDI, 0-64, high is worse, FV, <3 months PT)</span></h3></div><div id="ch6.appe.fig263" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20263.%20Emotional%20dysregulation%20(Self%2C%20BDI%2C%200-64%2C%20high%20is%20worse%2C%20FV%2C%20%3C3%20months%20FU).&p=BOOKS&id=578099_ch6appef263.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef263.jpg" alt="Figure 263. Emotional dysregulation (Self, BDI, 0-64, high is worse, FV, <3 months FU)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 263</span><span class="title">Emotional dysregulation (Self, BDI, 0-64, high is worse, FV, <3 months FU)</span></h3></div><div id="ch6.appe.fig264" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20264.%20Behaviour%2Ffunction%20(Self-rated%2C%20RATE%20antisocial%20scale%2C%20unclear%20range%2C%20high%20is%20worse%2C%20FV%2C%20%3C3%20months%20PT).&p=BOOKS&id=578099_ch6appef264.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef264.jpg" alt="Figure 264. Behaviour/function (Self-rated, RATE antisocial scale, unclear range, high is worse, FV, <3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 264</span><span class="title">Behaviour/function (Self-rated, RATE antisocial scale, unclear range, high is worse, FV, <3 months PT)</span></h3></div><div id="ch6.appe.fig265" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20265.%20Behaviour%2Ffunction%20(Self-rated%2C%20RATE%20antisocial%20scale%2C%20unclear%20range%2C%20high%20is%20worse%2C%20FV%2C%20%3C3%20months%20FU).&p=BOOKS&id=578099_ch6appef265.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef265.jpg" alt="Figure 265. Behaviour/function (Self-rated, RATE antisocial scale, unclear range, high is worse, FV, <3 months FU)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 265</span><span class="title">Behaviour/function (Self-rated, RATE antisocial scale, unclear range, high is worse, FV, <3 months FU)</span></h3></div></div><div id="ch6.appe.s2.3.3"><h5>E.2.3.3. Mixed medication + CBT/DBT versus mixed medication + NSST</h5><div id="ch6.appe.fig266" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20266.%20QoL%20(QLESQ%2C%20unclear%20scale%2C%20high%20is%20better%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef266.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef266.jpg" alt="Figure 266. QoL (QLESQ, unclear scale, high is better, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 266</span><span class="title">QoL (QLESQ, unclear scale, high is better, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig267" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20267.%20ADHD%20symptoms%20(total%2C%20self%2C%20ADHD-RS%2C%20high%20is%20worse%2C%20FV%2C%200-54%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef267.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef267.jpg" alt="Figure 267. ADHD symptoms (total, self, ADHD-RS, high is worse, FV, 0-54, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 267</span><span class="title">ADHD symptoms (total, self, ADHD-RS, high is worse, FV, 0-54, >3 months PT)</span></h3></div><div id="ch6.appe.fig268" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20268.%20ADHD%20symptoms%20(total%2C%20self%2C%20ADHD-RS%2C%20high%20is%20worse%2C%20FV%2C%200-54%2C%20%3E3%20months%20FU).&p=BOOKS&id=578099_ch6appef268.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef268.jpg" alt="Figure 268. ADHD symptoms (total, self, ADHD-RS, high is worse, FV, 0-54, >3 months FU)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 268</span><span class="title">ADHD symptoms (total, self, ADHD-RS, high is worse, FV, 0-54, >3 months FU)</span></h3></div><div id="ch6.appe.fig269" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20269.%20ADHD%20symptoms%20(hyperactivity%2C%20self%2C%20CAARS%2C%20high%20is%20worse%2C%20FV%2C%200-27%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef269.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef269.jpg" alt="Figure 269. ADHD symptoms (hyperactivity, self, CAARS, high is worse, FV, 0-27, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 269</span><span class="title">ADHD symptoms (hyperactivity, self, CAARS, high is worse, FV, 0-27, >3 months PT)</span></h3></div><div id="ch6.appe.fig270" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20270.%20ADHD%20symptoms%20(inattention%2C%20self%2C%20CAARS%2C%20high%20is%20worse%2C%20FV%2C%200-27%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef270.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef270.jpg" alt="Figure 270. ADHD symptoms (inattention, self, CAARS, high is worse, FV, 0-27, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 270</span><span class="title">ADHD symptoms (inattention, self, CAARS, high is worse, FV, 0-27, >3 months PT)</span></h3></div><div id="ch6.appe.fig271" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20271.%20CGI-I%20responders%20(%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef271.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef271.jpg" alt="Figure 271. CGI-I responders (>3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 271</span><span class="title">CGI-I responders (>3 months PT)</span></h3></div><div id="ch6.appe.fig272" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20272.%20Emotional%20dysregulation%20(Self%2C%20BDI%2C%200-63%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef272.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef272.jpg" alt="Figure 272. Emotional dysregulation (Self, BDI, 0-63, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 272</span><span class="title">Emotional dysregulation (Self, BDI, 0-63, high is worse, FV, >3 months PT)</span></h3></div></div></div><div id="ch6.appe.s2.4"><h5>E.2.4. Combined treatment versus no treatment/usual care</h5><div id="ch6.appe.s2.4.1"><h5>E.2.4.1. Stimulants + CBT/DBT versus NSST alone</h5><div id="ch6.appe.fig273" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20273.%20ADHD%20symptoms%20(total%2C%20self%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef273.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef273.jpg" alt="Figure 273. ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 273</span><span class="title">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig274" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20274.%20ADHD%20symptoms%20(total%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef274.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef274.jpg" alt="Figure 274. ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 274</span><span class="title">ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig275" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20275.%20ADHD%20symptoms%20(hyperactivity%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef275.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef275.jpg" alt="Figure 275. ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 275</span><span class="title">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig276" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20276.%20ADHD%20symptoms%20(inattention%2C%20observer%2C%20CAARS%2C%200-30%2C%20high%20is%20worse%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef276.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef276.jpg" alt="Figure 276. ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 276</span><span class="title">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</span></h3></div><div id="ch6.appe.fig277" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20277.%20Emotional%20dysregulation%20(Self%2C%20BDI%2C%200-63%2C%20high%20is%20poor%2C%20FV%2C%20%3E3%20months%20PT).&p=BOOKS&id=578099_ch6appef277.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appef277.jpg" alt="Figure 277. Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 277</span><span class="title">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)</span></h3></div></div></div></div></div><div id="ch6.appf"><h3>Appendix F. GRADE tables</h3><div id="ch6.appf.s1"><h4>Children and young people (5-18 years old)</h4><div id="ch6.appf.s1.1"><h5>DRUGS versus NON-DRUGS</h5><div id="ch6.appf.tab1" class="table"><h3><span class="label">Table 49</span><span class="title">Clinical evidence profile: Atomoxetine versus Parent/Family training for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab1_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab1_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab1_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab1_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab1_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab1_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab1_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab1_1_1_1_1" id="hd_h_ch6.appf.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab1_1_1_1_1" id="hd_h_ch6.appf.tab1_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab1_1_1_1_1" id="hd_h_ch6.appf.tab1_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab1_1_1_1_1" id="hd_h_ch6.appf.tab1_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab1_1_1_1_1" id="hd_h_ch6.appf.tab1_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab1_1_1_1_1" id="hd_h_ch6.appf.tab1_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab1_1_1_1_1" id="hd_h_ch6.appf.tab1_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab1_1_1_1_2" id="hd_h_ch6.appf.tab1_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Atomoxetine</th><th headers="hd_h_ch6.appf.tab1_1_1_1_2" id="hd_h_ch6.appf.tab1_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">PT/FT</th><th headers="hd_h_ch6.appf.tab1_1_1_1_3" id="hd_h_ch6.appf.tab1_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab1_1_1_1_3" id="hd_h_ch6.appf.tab1_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_h_ch6.appf.tab1_1_1_2_3 hd_h_ch6.appf.tab1_1_1_2_4 hd_h_ch6.appf.tab1_1_1_2_5 hd_h_ch6.appf.tab1_1_1_2_6 hd_h_ch6.appf.tab1_1_1_2_7 hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_h_ch6.appf.tab1_1_1_2_9 hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_h_ch6.appf.tab1_1_1_2_11 hd_h_ch6.appf.tab1_1_1_1_4 hd_h_ch6.appf.tab1_1_1_1_5" id="hd_b_ch6.appf.tab1_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_3 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab1_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_4 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_5 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_6 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab1_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_7 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_9 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_11 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.21 lower (0.5 lower to 0.08 higher)</td><td headers="hd_h_ch6.appf.tab1_1_1_1_4 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
|
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<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab1_1_1_1_5 hd_b_ch6.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_h_ch6.appf.tab1_1_1_2_3 hd_h_ch6.appf.tab1_1_1_2_4 hd_h_ch6.appf.tab1_1_1_2_5 hd_h_ch6.appf.tab1_1_1_2_6 hd_h_ch6.appf.tab1_1_1_2_7 hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_h_ch6.appf.tab1_1_1_2_9 hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_h_ch6.appf.tab1_1_1_2_11 hd_h_ch6.appf.tab1_1_1_1_4 hd_h_ch6.appf.tab1_1_1_1_5" id="hd_b_ch6.appf.tab1_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_3 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab1_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_4 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_5 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_6 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab1_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_7 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_9 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_11 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.03 higher (0.35 lower to 0.41 higher)</td><td headers="hd_h_ch6.appf.tab1_1_1_1_4 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab1_1_1_1_5 hd_b_ch6.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_h_ch6.appf.tab1_1_1_2_3 hd_h_ch6.appf.tab1_1_1_2_4 hd_h_ch6.appf.tab1_1_1_2_5 hd_h_ch6.appf.tab1_1_1_2_6 hd_h_ch6.appf.tab1_1_1_2_7 hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_h_ch6.appf.tab1_1_1_2_9 hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_h_ch6.appf.tab1_1_1_2_11 hd_h_ch6.appf.tab1_1_1_1_4 hd_h_ch6.appf.tab1_1_1_1_5" id="hd_b_ch6.appf.tab1_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_3 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab1_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_4 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_5 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_6 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab1_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_7 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_9 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_11 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.32 lower (0.68 lower to 0.04 higher)</td><td headers="hd_h_ch6.appf.tab1_1_1_1_4 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab1_1_1_1_5 hd_b_ch6.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_h_ch6.appf.tab1_1_1_2_3 hd_h_ch6.appf.tab1_1_1_2_4 hd_h_ch6.appf.tab1_1_1_2_5 hd_h_ch6.appf.tab1_1_1_2_6 hd_h_ch6.appf.tab1_1_1_2_7 hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_h_ch6.appf.tab1_1_1_2_9 hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_h_ch6.appf.tab1_1_1_2_11 hd_h_ch6.appf.tab1_1_1_1_4 hd_h_ch6.appf.tab1_1_1_1_5" id="hd_b_ch6.appf.tab1_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_3 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab1_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_4 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_5 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_6 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab1_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_7 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_9 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_11 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.04 higher (0.43 lower to 0.51 higher)</td><td headers="hd_h_ch6.appf.tab1_1_1_1_4 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab1_1_1_1_5 hd_b_ch6.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_h_ch6.appf.tab1_1_1_2_3 hd_h_ch6.appf.tab1_1_1_2_4 hd_h_ch6.appf.tab1_1_1_2_5 hd_h_ch6.appf.tab1_1_1_2_6 hd_h_ch6.appf.tab1_1_1_2_7 hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_h_ch6.appf.tab1_1_1_2_9 hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_h_ch6.appf.tab1_1_1_2_11 hd_h_ch6.appf.tab1_1_1_1_4 hd_h_ch6.appf.tab1_1_1_1_5" id="hd_b_ch6.appf.tab1_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_3 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab1_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_4 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_5 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_6 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab1_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_7 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_9 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_11 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.09 lower (0.41 lower to 0.23 higher)</td><td headers="hd_h_ch6.appf.tab1_1_1_1_4 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab1_1_1_1_5 hd_b_ch6.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_h_ch6.appf.tab1_1_1_2_3 hd_h_ch6.appf.tab1_1_1_2_4 hd_h_ch6.appf.tab1_1_1_2_5 hd_h_ch6.appf.tab1_1_1_2_6 hd_h_ch6.appf.tab1_1_1_2_7 hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_h_ch6.appf.tab1_1_1_2_9 hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_h_ch6.appf.tab1_1_1_2_11 hd_h_ch6.appf.tab1_1_1_1_4 hd_h_ch6.appf.tab1_1_1_1_5" id="hd_b_ch6.appf.tab1_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_3 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab1_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_4 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_5 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_6 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab1_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_7 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_9 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_11 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.02 higher (0.37 lower to 0.41 higher)</td><td headers="hd_h_ch6.appf.tab1_1_1_1_4 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab1_1_1_1_5 hd_b_ch6.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_h_ch6.appf.tab1_1_1_2_3 hd_h_ch6.appf.tab1_1_1_2_4 hd_h_ch6.appf.tab1_1_1_2_5 hd_h_ch6.appf.tab1_1_1_2_6 hd_h_ch6.appf.tab1_1_1_2_7 hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_h_ch6.appf.tab1_1_1_2_9 hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_h_ch6.appf.tab1_1_1_2_11 hd_h_ch6.appf.tab1_1_1_1_4 hd_h_ch6.appf.tab1_1_1_1_5" id="hd_b_ch6.appf.tab1_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months) (follow-up 10 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_1 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_2 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_3 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab1_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_4 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_5 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_6 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab1_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab1_1_1_1_1 hd_h_ch6.appf.tab1_1_1_2_7 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_8 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>15/32</p>
|
||
<p>(46.9%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab1_1_1_1_2 hd_h_ch6.appf.tab1_1_1_2_9 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29%</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_10 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 1.61 (0.83 to 3.13)</td><td headers="hd_h_ch6.appf.tab1_1_1_1_3 hd_h_ch6.appf.tab1_1_1_2_11 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">177 more per 1000 (from 49 fewer to 618 more)</td><td headers="hd_h_ch6.appf.tab1_1_1_1_4 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab1_1_1_1_5 hd_b_ch6.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab1_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab1_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab2" class="table"><h3><span class="label">Table 50</span><span class="title">Clinical evidence profile: Stimulants versus exercise for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab2_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab2_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab2_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab2_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab2_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab2_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab2_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab2_1_1_1_1" id="hd_h_ch6.appf.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab2_1_1_1_1" id="hd_h_ch6.appf.tab2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab2_1_1_1_1" id="hd_h_ch6.appf.tab2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab2_1_1_1_1" id="hd_h_ch6.appf.tab2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab2_1_1_1_1" id="hd_h_ch6.appf.tab2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab2_1_1_1_1" id="hd_h_ch6.appf.tab2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab2_1_1_1_1" id="hd_h_ch6.appf.tab2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab2_1_1_1_2" id="hd_h_ch6.appf.tab2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants</th><th headers="hd_h_ch6.appf.tab2_1_1_1_2" id="hd_h_ch6.appf.tab2_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Exercise</th><th headers="hd_h_ch6.appf.tab2_1_1_1_3" id="hd_h_ch6.appf.tab2_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab2_1_1_1_3" id="hd_h_ch6.appf.tab2_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_1 hd_h_ch6.appf.tab2_1_1_2_2 hd_h_ch6.appf.tab2_1_1_2_3 hd_h_ch6.appf.tab2_1_1_2_4 hd_h_ch6.appf.tab2_1_1_2_5 hd_h_ch6.appf.tab2_1_1_2_6 hd_h_ch6.appf.tab2_1_1_2_7 hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_8 hd_h_ch6.appf.tab2_1_1_2_9 hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_10 hd_h_ch6.appf.tab2_1_1_2_11 hd_h_ch6.appf.tab2_1_1_1_4 hd_h_ch6.appf.tab2_1_1_1_5" id="hd_b_ch6.appf.tab2_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SWAN, 0-3, high is poor, FV, PT <3 months) (follow-up 10-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_1 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_2 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_3 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab2_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_4 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_5 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_6 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab2_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_7 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_8 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_9 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">37</td><td headers="hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_10 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_11 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.45 lower (0.84 to 0.06 lower)</td><td headers="hd_h_ch6.appf.tab2_1_1_1_4 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab2_1_1_1_5 hd_b_ch6.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_1 hd_h_ch6.appf.tab2_1_1_2_2 hd_h_ch6.appf.tab2_1_1_2_3 hd_h_ch6.appf.tab2_1_1_2_4 hd_h_ch6.appf.tab2_1_1_2_5 hd_h_ch6.appf.tab2_1_1_2_6 hd_h_ch6.appf.tab2_1_1_2_7 hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_8 hd_h_ch6.appf.tab2_1_1_2_9 hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_10 hd_h_ch6.appf.tab2_1_1_2_11 hd_h_ch6.appf.tab2_1_1_1_4 hd_h_ch6.appf.tab2_1_1_1_5" id="hd_b_ch6.appf.tab2_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SWAN, 0-3, high is poor, FV, PT <3 months) (follow-up 10-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_1 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_2 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_3 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab2_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_4 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_5 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_6 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab2_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_7 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_8 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33</td><td headers="hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_9 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">37</td><td headers="hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_10 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_11 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.87 lower (1.3 to 0.44 lower)</td><td headers="hd_h_ch6.appf.tab2_1_1_1_4 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab2_1_1_1_5 hd_b_ch6.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_1 hd_h_ch6.appf.tab2_1_1_2_2 hd_h_ch6.appf.tab2_1_1_2_3 hd_h_ch6.appf.tab2_1_1_2_4 hd_h_ch6.appf.tab2_1_1_2_5 hd_h_ch6.appf.tab2_1_1_2_6 hd_h_ch6.appf.tab2_1_1_2_7 hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_8 hd_h_ch6.appf.tab2_1_1_2_9 hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_10 hd_h_ch6.appf.tab2_1_1_2_11 hd_h_ch6.appf.tab2_1_1_1_4 hd_h_ch6.appf.tab2_1_1_1_5" id="hd_b_ch6.appf.tab2_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SWAN, 0-3, high is poor, FV, PT <3 months) (follow-up 10-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_1 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_2 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_3 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab2_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_4 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_5 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_6 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab2_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_7 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_8 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_9 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">37</td><td headers="hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_10 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_11 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.50 lower (0.86 to 0.14 lower)</td><td headers="hd_h_ch6.appf.tab2_1_1_1_4 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab2_1_1_1_5 hd_b_ch6.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_1 hd_h_ch6.appf.tab2_1_1_2_2 hd_h_ch6.appf.tab2_1_1_2_3 hd_h_ch6.appf.tab2_1_1_2_4 hd_h_ch6.appf.tab2_1_1_2_5 hd_h_ch6.appf.tab2_1_1_2_6 hd_h_ch6.appf.tab2_1_1_2_7 hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_8 hd_h_ch6.appf.tab2_1_1_2_9 hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_10 hd_h_ch6.appf.tab2_1_1_2_11 hd_h_ch6.appf.tab2_1_1_1_4 hd_h_ch6.appf.tab2_1_1_1_5" id="hd_b_ch6.appf.tab2_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SWAN, 0-3, high is poor, FV, PT <3 months) (follow-up 10-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_1 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_2 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_3 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab2_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_4 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_5 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_6 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab2_1_1_1_1 hd_h_ch6.appf.tab2_1_1_2_7 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_8 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33</td><td headers="hd_h_ch6.appf.tab2_1_1_1_2 hd_h_ch6.appf.tab2_1_1_2_9 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">37</td><td headers="hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_10 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab2_1_1_1_3 hd_h_ch6.appf.tab2_1_1_2_11 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.76 lower (1.12 to 0.4 lower)</td><td headers="hd_h_ch6.appf.tab2_1_1_1_4 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab2_1_1_1_5 hd_b_ch6.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab2_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab2_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab3" class="table"><h3><span class="label">Table 51</span><span class="title">Clinical evidence profile: Stimulants versus Neurofeedback for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab3_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab3_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab3_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab3_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab3_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab3_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab3_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1" id="hd_h_ch6.appf.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab3_1_1_1_1" id="hd_h_ch6.appf.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab3_1_1_1_1" id="hd_h_ch6.appf.tab3_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab3_1_1_1_1" id="hd_h_ch6.appf.tab3_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab3_1_1_1_1" id="hd_h_ch6.appf.tab3_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab3_1_1_1_1" id="hd_h_ch6.appf.tab3_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab3_1_1_1_1" id="hd_h_ch6.appf.tab3_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab3_1_1_1_2" id="hd_h_ch6.appf.tab3_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants</th><th headers="hd_h_ch6.appf.tab3_1_1_1_2" id="hd_h_ch6.appf.tab3_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NF</th><th headers="hd_h_ch6.appf.tab3_1_1_1_3" id="hd_h_ch6.appf.tab3_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab3_1_1_1_3" id="hd_h_ch6.appf.tab3_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.60 higher (0.46 to 8.74 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
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||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 lower (5.21 lower to 4.61 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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||
<p>⨁◯◯◯</p>
|
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<p>VERY LOW</p>
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||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.70 higher (2.93 lower to 8.33 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.80 higher (4.45 lower to 6.05 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.00 higher (0.49 to 5.51 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.40 higher (1.43 lower to 4.23 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SWAN, 0-3, high is poor, FV, PT <3 months) (follow-up 10-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_4">4</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.40 lower (0.79 to 0.01 lower)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.40 higher (3.33 lower to 4.13 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.50 higher (0.59 lower to 5.59 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SWAN, 0-3, high is poor, FV, PT <3 months) (follow-up 10-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_4">4</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.93 lower (1.39 to 0.47 lower)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 lower (1.63 lower to 1.43 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.60 higher (0.90 lower to 2.10 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_25_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 higher (1.18 lower to 1.38 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_27_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.60 higher (0.91 lower to 4.11 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_29_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.80 lower (4.42 lower to 0.82 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_31_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SWAN, 0-3, high is poor, FV, PT <3 months) (follow-up 10-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_4">4</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.50 lower (0.84 to 0.16 lower)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_33_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.30 higher (0.55 lower to 5.15 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_35_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.70 lower (4.53 lower to 1.13 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_37_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SWAN, 0-3, high is poor, FV, PT <3 months) (follow-up 10-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_4">4</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.73 lower (1.09 to 0.37 lower)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_39_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 higher (1.02 lower to 1.42 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_41_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.40 higher (0.68 lower to 1.48 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_43_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <<sup><a class="bk_pop" href="#ch6.appf.tab3_3">3</a></sup> months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.40 lower (1.75 lower to 0.95 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_43_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_45_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <3 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.40 lower (3.22 lower to 0.42 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_45_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_47_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.60 higher (0.90 lower to 2.10 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_47_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_h_ch6.appf.tab3_1_1_2_3 hd_h_ch6.appf.tab3_1_1_2_4 hd_h_ch6.appf.tab3_1_1_2_5 hd_h_ch6.appf.tab3_1_1_2_6 hd_h_ch6.appf.tab3_1_1_2_7 hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_h_ch6.appf.tab3_1_1_2_9 hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_h_ch6.appf.tab3_1_1_2_11 hd_h_ch6.appf.tab3_1_1_1_4 hd_h_ch6.appf.tab3_1_1_1_5" id="hd_b_ch6.appf.tab3_1_1_49_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_1 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_2 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_3 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab3_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_4 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_5 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_6 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab3_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab3_1_1_1_1 hd_h_ch6.appf.tab3_1_1_2_7 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_8 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab3_1_1_1_2 hd_h_ch6.appf.tab3_1_1_2_9 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_10 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab3_1_1_1_3 hd_h_ch6.appf.tab3_1_1_2_11 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 higher (1.18 lower to 1.38 higher)</td><td headers="hd_h_ch6.appf.tab3_1_1_1_4 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab3_1_1_1_5 hd_b_ch6.appf.tab3_1_1_49_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab3_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab3_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>3</dt><dd><div id="ch6.appf.tab3_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>4</dt><dd><div id="ch6.appf.tab3_4"><p class="no_margin">Downgraded by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab4" class="table"><h3><span class="label">Table 52</span><span class="title">Clinical evidence profile: Stimulants + NSST versus stimulants for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab4_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab4_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab4_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab4_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab4_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab4_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab4_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab4_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab4_1_1_1_1" id="hd_h_ch6.appf.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab4_1_1_1_1" id="hd_h_ch6.appf.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab4_1_1_1_1" id="hd_h_ch6.appf.tab4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab4_1_1_1_1" id="hd_h_ch6.appf.tab4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab4_1_1_1_1" id="hd_h_ch6.appf.tab4_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab4_1_1_1_1" id="hd_h_ch6.appf.tab4_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab4_1_1_1_1" id="hd_h_ch6.appf.tab4_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab4_1_1_1_2" id="hd_h_ch6.appf.tab4_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + NSST versus stimulants</th><th headers="hd_h_ch6.appf.tab4_1_1_1_2" id="hd_h_ch6.appf.tab4_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Control</th><th headers="hd_h_ch6.appf.tab4_1_1_1_3" id="hd_h_ch6.appf.tab4_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab4_1_1_1_3" id="hd_h_ch6.appf.tab4_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_1 hd_h_ch6.appf.tab4_1_1_2_2 hd_h_ch6.appf.tab4_1_1_2_3 hd_h_ch6.appf.tab4_1_1_2_4 hd_h_ch6.appf.tab4_1_1_2_5 hd_h_ch6.appf.tab4_1_1_2_6 hd_h_ch6.appf.tab4_1_1_2_7 hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_8 hd_h_ch6.appf.tab4_1_1_2_9 hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_10 hd_h_ch6.appf.tab4_1_1_2_11 hd_h_ch6.appf.tab4_1_1_1_4 hd_h_ch6.appf.tab4_1_1_1_5" id="hd_b_ch6.appf.tab4_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, PT >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_1 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_2 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_3 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_4 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_5 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_6 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab4_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_7 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_8 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_9 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4</td><td headers="hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_10 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_11 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 lower (0.38 lower to 0.18 higher)</td><td headers="hd_h_ch6.appf.tab4_1_1_1_4 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab4_1_1_1_5 hd_b_ch6.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_1 hd_h_ch6.appf.tab4_1_1_2_2 hd_h_ch6.appf.tab4_1_1_2_3 hd_h_ch6.appf.tab4_1_1_2_4 hd_h_ch6.appf.tab4_1_1_2_5 hd_h_ch6.appf.tab4_1_1_2_6 hd_h_ch6.appf.tab4_1_1_2_7 hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_8 hd_h_ch6.appf.tab4_1_1_2_9 hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_10 hd_h_ch6.appf.tab4_1_1_2_11 hd_h_ch6.appf.tab4_1_1_1_4 hd_h_ch6.appf.tab4_1_1_1_5" id="hd_b_ch6.appf.tab4_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_1 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_2 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_3 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_4 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_5 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_6 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab4_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_7 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_8 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_9 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_10 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_11 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 lower (0.44 lower to 0.04 higher)</td><td headers="hd_h_ch6.appf.tab4_1_1_1_4 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab4_1_1_1_5 hd_b_ch6.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_1 hd_h_ch6.appf.tab4_1_1_2_2 hd_h_ch6.appf.tab4_1_1_2_3 hd_h_ch6.appf.tab4_1_1_2_4 hd_h_ch6.appf.tab4_1_1_2_5 hd_h_ch6.appf.tab4_1_1_2_6 hd_h_ch6.appf.tab4_1_1_2_7 hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_8 hd_h_ch6.appf.tab4_1_1_2_9 hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_10 hd_h_ch6.appf.tab4_1_1_2_11 hd_h_ch6.appf.tab4_1_1_1_4 hd_h_ch6.appf.tab4_1_1_1_5" id="hd_b_ch6.appf.tab4_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_1 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_2 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_3 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_4 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_5 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_6 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab4_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_7 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_8 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_9 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_10 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_11 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 lower (0.68 lower to 0.08 higher)</td><td headers="hd_h_ch6.appf.tab4_1_1_1_4 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab4_1_1_1_5 hd_b_ch6.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_1 hd_h_ch6.appf.tab4_1_1_2_2 hd_h_ch6.appf.tab4_1_1_2_3 hd_h_ch6.appf.tab4_1_1_2_4 hd_h_ch6.appf.tab4_1_1_2_5 hd_h_ch6.appf.tab4_1_1_2_6 hd_h_ch6.appf.tab4_1_1_2_7 hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_8 hd_h_ch6.appf.tab4_1_1_2_9 hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_10 hd_h_ch6.appf.tab4_1_1_2_11 hd_h_ch6.appf.tab4_1_1_1_4 hd_h_ch6.appf.tab4_1_1_1_5" id="hd_b_ch6.appf.tab4_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_1 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_2 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_3 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab4_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_4 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_5 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_6 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab4_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab4_1_1_1_1 hd_h_ch6.appf.tab4_1_1_2_7 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_8 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab4_1_1_1_2 hd_h_ch6.appf.tab4_1_1_2_9 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_10 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab4_1_1_1_3 hd_h_ch6.appf.tab4_1_1_2_11 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.40 lower (0.7 to 0.1 lower)</td><td headers="hd_h_ch6.appf.tab4_1_1_1_4 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab4_1_1_1_5 hd_b_ch6.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab4_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab4_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab5" class="table"><h3><span class="label">Table 53</span><span class="title">Clinical evidence profile: Mixed medication versus PT/FT for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab5_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab5_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab5_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab5_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab5_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab5_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab5_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab5_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1" id="hd_h_ch6.appf.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab5_1_1_1_1" id="hd_h_ch6.appf.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab5_1_1_1_1" id="hd_h_ch6.appf.tab5_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab5_1_1_1_1" id="hd_h_ch6.appf.tab5_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab5_1_1_1_1" id="hd_h_ch6.appf.tab5_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab5_1_1_1_1" id="hd_h_ch6.appf.tab5_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab5_1_1_1_1" id="hd_h_ch6.appf.tab5_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab5_1_1_1_2" id="hd_h_ch6.appf.tab5_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication</th><th headers="hd_h_ch6.appf.tab5_1_1_1_2" id="hd_h_ch6.appf.tab5_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">PT/FT</th><th headers="hd_h_ch6.appf.tab5_1_1_1_3" id="hd_h_ch6.appf.tab5_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab5_1_1_1_3" id="hd_h_ch6.appf.tab5_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">115</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.06 lower (0.21 lower to 0.09 higher)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">120</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">119</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.28 lower (0.47 to 0.09 lower)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">121</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">129</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.33 lower (0.5 to 0.16 lower)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">110</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">107</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.13 lower (0.19 to 0.07 lower)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">121</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">129</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.28 lower (0.45 to 0.11 lower)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">120</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">120</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.36 lower (0.56 to 0.16 lower)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, %, high is better, PT <3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab5_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.14 lower (7.04 to 1.24 lower)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">124</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.60 lower (3.86 lower to 2.66 higher)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab5_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 5.45 lower (9.36 to 1.54 lower)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">124</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.70 higher (1.84 lower to 5.24 higher)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_h_ch6.appf.tab5_1_1_2_3 hd_h_ch6.appf.tab5_1_1_2_4 hd_h_ch6.appf.tab5_1_1_2_5 hd_h_ch6.appf.tab5_1_1_2_6 hd_h_ch6.appf.tab5_1_1_2_7 hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_h_ch6.appf.tab5_1_1_2_9 hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_h_ch6.appf.tab5_1_1_2_11 hd_h_ch6.appf.tab5_1_1_1_4 hd_h_ch6.appf.tab5_1_1_1_5" id="hd_b_ch6.appf.tab5_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_1 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_2 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_3 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab5_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_4 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_5 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_6 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab5_1_1_1_1 hd_h_ch6.appf.tab5_1_1_2_7 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_8 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">115</td><td headers="hd_h_ch6.appf.tab5_1_1_1_2 hd_h_ch6.appf.tab5_1_1_2_9 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_10 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab5_1_1_1_3 hd_h_ch6.appf.tab5_1_1_2_11 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.50 lower (3.98 lower to 2.98 higher)</td><td headers="hd_h_ch6.appf.tab5_1_1_1_4 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab5_1_1_1_5 hd_b_ch6.appf.tab5_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab5_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab5_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>3</dt><dd><div id="ch6.appf.tab5_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div id="ch6.appf.s1.2"><h5>COMBINATION versus NON-DRUGS</h5><div id="ch6.appf.tab6" class="table"><h3><span class="label">Table 54</span><span class="title">Clinical evidence profile: Atomoxetine + PT/FT versus PT/FT for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab6_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab6_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab6_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab6_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab6_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab6_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab6_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab6_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab6_1_1_1_1" id="hd_h_ch6.appf.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab6_1_1_1_1" id="hd_h_ch6.appf.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab6_1_1_1_1" id="hd_h_ch6.appf.tab6_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab6_1_1_1_1" id="hd_h_ch6.appf.tab6_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab6_1_1_1_1" id="hd_h_ch6.appf.tab6_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab6_1_1_1_1" id="hd_h_ch6.appf.tab6_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab6_1_1_1_1" id="hd_h_ch6.appf.tab6_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab6_1_1_1_2" id="hd_h_ch6.appf.tab6_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Atomoxetine + PT/FT</th><th headers="hd_h_ch6.appf.tab6_1_1_1_2" id="hd_h_ch6.appf.tab6_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">PT/FT</th><th headers="hd_h_ch6.appf.tab6_1_1_1_3" id="hd_h_ch6.appf.tab6_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab6_1_1_1_3" id="hd_h_ch6.appf.tab6_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_h_ch6.appf.tab6_1_1_2_3 hd_h_ch6.appf.tab6_1_1_2_4 hd_h_ch6.appf.tab6_1_1_2_5 hd_h_ch6.appf.tab6_1_1_2_6 hd_h_ch6.appf.tab6_1_1_2_7 hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_h_ch6.appf.tab6_1_1_2_9 hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_h_ch6.appf.tab6_1_1_2_11 hd_h_ch6.appf.tab6_1_1_1_4 hd_h_ch6.appf.tab6_1_1_1_5" id="hd_b_ch6.appf.tab6_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_3 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_4 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_5 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_6 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_7 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_9 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_11 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.22 lower (0.54 lower to 0.1 higher)</td><td headers="hd_h_ch6.appf.tab6_1_1_1_4 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab6_1_1_1_5 hd_b_ch6.appf.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_h_ch6.appf.tab6_1_1_2_3 hd_h_ch6.appf.tab6_1_1_2_4 hd_h_ch6.appf.tab6_1_1_2_5 hd_h_ch6.appf.tab6_1_1_2_6 hd_h_ch6.appf.tab6_1_1_2_7 hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_h_ch6.appf.tab6_1_1_2_9 hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_h_ch6.appf.tab6_1_1_2_11 hd_h_ch6.appf.tab6_1_1_1_4 hd_h_ch6.appf.tab6_1_1_1_5" id="hd_b_ch6.appf.tab6_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_3 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_4 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_5 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_6 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_7 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_9 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_11 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.32 lower (0.72 lower to 0.08 higher)</td><td headers="hd_h_ch6.appf.tab6_1_1_1_4 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab6_1_1_1_5 hd_b_ch6.appf.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_h_ch6.appf.tab6_1_1_2_3 hd_h_ch6.appf.tab6_1_1_2_4 hd_h_ch6.appf.tab6_1_1_2_5 hd_h_ch6.appf.tab6_1_1_2_6 hd_h_ch6.appf.tab6_1_1_2_7 hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_h_ch6.appf.tab6_1_1_2_9 hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_h_ch6.appf.tab6_1_1_2_11 hd_h_ch6.appf.tab6_1_1_1_4 hd_h_ch6.appf.tab6_1_1_1_5" id="hd_b_ch6.appf.tab6_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_3 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_4 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_5 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_6 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_7 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_9 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_11 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.29 lower (0.65 lower to 0.07 higher)</td><td headers="hd_h_ch6.appf.tab6_1_1_1_4 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab6_1_1_1_5 hd_b_ch6.appf.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_h_ch6.appf.tab6_1_1_2_3 hd_h_ch6.appf.tab6_1_1_2_4 hd_h_ch6.appf.tab6_1_1_2_5 hd_h_ch6.appf.tab6_1_1_2_6 hd_h_ch6.appf.tab6_1_1_2_7 hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_h_ch6.appf.tab6_1_1_2_9 hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_h_ch6.appf.tab6_1_1_2_11 hd_h_ch6.appf.tab6_1_1_1_4 hd_h_ch6.appf.tab6_1_1_1_5" id="hd_b_ch6.appf.tab6_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_3 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_4 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_5 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_6 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_7 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_9 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_11 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 lower (0.77 lower to 0.17 higher)</td><td headers="hd_h_ch6.appf.tab6_1_1_1_4 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab6_1_1_1_5 hd_b_ch6.appf.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_h_ch6.appf.tab6_1_1_2_3 hd_h_ch6.appf.tab6_1_1_2_4 hd_h_ch6.appf.tab6_1_1_2_5 hd_h_ch6.appf.tab6_1_1_2_6 hd_h_ch6.appf.tab6_1_1_2_7 hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_h_ch6.appf.tab6_1_1_2_9 hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_h_ch6.appf.tab6_1_1_2_11 hd_h_ch6.appf.tab6_1_1_1_4 hd_h_ch6.appf.tab6_1_1_1_5" id="hd_b_ch6.appf.tab6_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_3 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_4 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_5 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_6 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_7 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_9 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_11 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.15 lower (0.5 lower to 0.2 higher)</td><td headers="hd_h_ch6.appf.tab6_1_1_1_4 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab6_1_1_1_5 hd_b_ch6.appf.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_h_ch6.appf.tab6_1_1_2_3 hd_h_ch6.appf.tab6_1_1_2_4 hd_h_ch6.appf.tab6_1_1_2_5 hd_h_ch6.appf.tab6_1_1_2_6 hd_h_ch6.appf.tab6_1_1_2_7 hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_h_ch6.appf.tab6_1_1_2_9 hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_h_ch6.appf.tab6_1_1_2_11 hd_h_ch6.appf.tab6_1_1_1_4 hd_h_ch6.appf.tab6_1_1_1_5" id="hd_b_ch6.appf.tab6_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_3 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_4 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_5 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_6 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_7 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_9 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_11 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.34 lower (0.75 lower to 0.07 higher)</td><td headers="hd_h_ch6.appf.tab6_1_1_1_4 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab6_1_1_1_5 hd_b_ch6.appf.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_h_ch6.appf.tab6_1_1_2_3 hd_h_ch6.appf.tab6_1_1_2_4 hd_h_ch6.appf.tab6_1_1_2_5 hd_h_ch6.appf.tab6_1_1_2_6 hd_h_ch6.appf.tab6_1_1_2_7 hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_h_ch6.appf.tab6_1_1_2_9 hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_h_ch6.appf.tab6_1_1_2_11 hd_h_ch6.appf.tab6_1_1_1_4 hd_h_ch6.appf.tab6_1_1_1_5" id="hd_b_ch6.appf.tab6_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months) (follow-up 10 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_1 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_2 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_3 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_4 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_5 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_6 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab6_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab6_1_1_1_1 hd_h_ch6.appf.tab6_1_1_2_7 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_8 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>15/31</p>
|
||
<p>(48.4%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab6_1_1_1_2 hd_h_ch6.appf.tab6_1_1_2_9 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29%</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_10 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 1.67 (0.86 to 3.22)</td><td headers="hd_h_ch6.appf.tab6_1_1_1_3 hd_h_ch6.appf.tab6_1_1_2_11 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">194 more per 1000 (from 41 fewer to 644 more)</td><td headers="hd_h_ch6.appf.tab6_1_1_1_4 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab6_1_1_1_5 hd_b_ch6.appf.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab6_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab6_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab7" class="table"><h3><span class="label">Table 55</span><span class="title">Clinical evidence profile: Atomoxetine + PE versus PE for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab7_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab7_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab7_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab7_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab7_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab7_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab7_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab7_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab7_1_1_1_1" id="hd_h_ch6.appf.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab7_1_1_1_1" id="hd_h_ch6.appf.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab7_1_1_1_1" id="hd_h_ch6.appf.tab7_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab7_1_1_1_1" id="hd_h_ch6.appf.tab7_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab7_1_1_1_1" id="hd_h_ch6.appf.tab7_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab7_1_1_1_1" id="hd_h_ch6.appf.tab7_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab7_1_1_1_1" id="hd_h_ch6.appf.tab7_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab7_1_1_1_2" id="hd_h_ch6.appf.tab7_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Atomoxetine + PE</th><th headers="hd_h_ch6.appf.tab7_1_1_1_2" id="hd_h_ch6.appf.tab7_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">PE</th><th headers="hd_h_ch6.appf.tab7_1_1_1_3" id="hd_h_ch6.appf.tab7_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab7_1_1_1_3" id="hd_h_ch6.appf.tab7_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_h_ch6.appf.tab7_1_1_2_3 hd_h_ch6.appf.tab7_1_1_2_4 hd_h_ch6.appf.tab7_1_1_2_5 hd_h_ch6.appf.tab7_1_1_2_6 hd_h_ch6.appf.tab7_1_1_2_7 hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_h_ch6.appf.tab7_1_1_2_9 hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_h_ch6.appf.tab7_1_1_2_11 hd_h_ch6.appf.tab7_1_1_1_4 hd_h_ch6.appf.tab7_1_1_1_5" id="hd_b_ch6.appf.tab7_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Quality of life (parent rated, total CHIP-CE, unclear range, high is good outcome, CS, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_3 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_4 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_5 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_6 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab7_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_7 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_9 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">50</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_11 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.40 higher (1.93 lower to 4.73 higher)</td><td headers="hd_h_ch6.appf.tab7_1_1_1_4 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁⨁⨁◯</p>
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<p>MODERATE</p>
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</td><td headers="hd_h_ch6.appf.tab7_1_1_1_5 hd_b_ch6.appf.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_h_ch6.appf.tab7_1_1_2_3 hd_h_ch6.appf.tab7_1_1_2_4 hd_h_ch6.appf.tab7_1_1_2_5 hd_h_ch6.appf.tab7_1_1_2_6 hd_h_ch6.appf.tab7_1_1_2_7 hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_h_ch6.appf.tab7_1_1_2_9 hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_h_ch6.appf.tab7_1_1_2_11 hd_h_ch6.appf.tab7_1_1_1_4 hd_h_ch6.appf.tab7_1_1_1_5" id="hd_b_ch6.appf.tab7_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_3 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_4 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_5 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_6 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_7 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_9 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">50</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_11 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 12.70 lower (16.86 to 8.54 lower)</td><td headers="hd_h_ch6.appf.tab7_1_1_1_4 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">⨁⨁⨁⨁ HIGH</td><td headers="hd_h_ch6.appf.tab7_1_1_1_5 hd_b_ch6.appf.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_h_ch6.appf.tab7_1_1_2_3 hd_h_ch6.appf.tab7_1_1_2_4 hd_h_ch6.appf.tab7_1_1_2_5 hd_h_ch6.appf.tab7_1_1_2_6 hd_h_ch6.appf.tab7_1_1_2_7 hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_h_ch6.appf.tab7_1_1_2_9 hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_h_ch6.appf.tab7_1_1_2_11 hd_h_ch6.appf.tab7_1_1_1_4 hd_h_ch6.appf.tab7_1_1_1_5" id="hd_b_ch6.appf.tab7_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_3 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_4 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_5 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_6 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_7 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_9 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">50</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_11 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 6.20 lower (8.42 to 3.98 lower)</td><td headers="hd_h_ch6.appf.tab7_1_1_1_4 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">⨁⨁⨁⨁ HIGH</td><td headers="hd_h_ch6.appf.tab7_1_1_1_5 hd_b_ch6.appf.tab7_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_h_ch6.appf.tab7_1_1_2_3 hd_h_ch6.appf.tab7_1_1_2_4 hd_h_ch6.appf.tab7_1_1_2_5 hd_h_ch6.appf.tab7_1_1_2_6 hd_h_ch6.appf.tab7_1_1_2_7 hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_h_ch6.appf.tab7_1_1_2_9 hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_h_ch6.appf.tab7_1_1_2_11 hd_h_ch6.appf.tab7_1_1_1_4 hd_h_ch6.appf.tab7_1_1_1_5" id="hd_b_ch6.appf.tab7_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_3 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_4 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_5 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_6 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_7 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_9 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">50</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_11 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 6.50 lower (8.5 to 4.5 lower)</td><td headers="hd_h_ch6.appf.tab7_1_1_1_4 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">⨁⨁⨁⨁ HIGH</td><td headers="hd_h_ch6.appf.tab7_1_1_1_5 hd_b_ch6.appf.tab7_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_h_ch6.appf.tab7_1_1_2_3 hd_h_ch6.appf.tab7_1_1_2_4 hd_h_ch6.appf.tab7_1_1_2_5 hd_h_ch6.appf.tab7_1_1_2_6 hd_h_ch6.appf.tab7_1_1_2_7 hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_h_ch6.appf.tab7_1_1_2_9 hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_h_ch6.appf.tab7_1_1_2_11 hd_h_ch6.appf.tab7_1_1_1_4 hd_h_ch6.appf.tab7_1_1_1_5" id="hd_b_ch6.appf.tab7_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (parent rated, academic CHIP-CE, unclear range, high is good outcome, CS, PT <3 months) (follow-up 10 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_1 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_2 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_3 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_4 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_5 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_6 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab7_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab7_1_1_1_1 hd_h_ch6.appf.tab7_1_1_2_7 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_8 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49</td><td headers="hd_h_ch6.appf.tab7_1_1_1_2 hd_h_ch6.appf.tab7_1_1_2_9 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">50</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_10 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab7_1_1_1_3 hd_h_ch6.appf.tab7_1_1_2_11 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.30 higher (0.83 to 7.77 higher)</td><td headers="hd_h_ch6.appf.tab7_1_1_1_4 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁⨁⨁◯</p>
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<p>MODERATE</p>
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</td><td headers="hd_h_ch6.appf.tab7_1_1_1_5 hd_b_ch6.appf.tab7_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab7_1"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab8" class="table"><h3><span class="label">Table 56</span><span class="title">Clinical evidence profile: Atomoxetine + CBT versus CBT for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab8_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab8_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab8_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab8_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab8_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab8_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab8_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab8_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab8_1_1_1_1" id="hd_h_ch6.appf.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab8_1_1_1_1" id="hd_h_ch6.appf.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab8_1_1_1_1" id="hd_h_ch6.appf.tab8_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab8_1_1_1_1" id="hd_h_ch6.appf.tab8_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab8_1_1_1_1" id="hd_h_ch6.appf.tab8_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab8_1_1_1_1" id="hd_h_ch6.appf.tab8_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab8_1_1_1_1" id="hd_h_ch6.appf.tab8_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab8_1_1_1_2" id="hd_h_ch6.appf.tab8_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Atomoxetine + CBT</th><th headers="hd_h_ch6.appf.tab8_1_1_1_2" id="hd_h_ch6.appf.tab8_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CBT</th><th headers="hd_h_ch6.appf.tab8_1_1_1_3" id="hd_h_ch6.appf.tab8_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab8_1_1_1_3" id="hd_h_ch6.appf.tab8_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_1 hd_h_ch6.appf.tab8_1_1_2_2 hd_h_ch6.appf.tab8_1_1_2_3 hd_h_ch6.appf.tab8_1_1_2_4 hd_h_ch6.appf.tab8_1_1_2_5 hd_h_ch6.appf.tab8_1_1_2_6 hd_h_ch6.appf.tab8_1_1_2_7 hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_8 hd_h_ch6.appf.tab8_1_1_2_9 hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_10 hd_h_ch6.appf.tab8_1_1_2_11 hd_h_ch6.appf.tab8_1_1_1_4 hd_h_ch6.appf.tab8_1_1_1_5" id="hd_b_ch6.appf.tab8_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, DSM-IV checklist, 0-54, high is poor, CS, PT <3 months) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_1 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_2 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_3 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab8_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_4 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_5 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_6 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab8_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_7 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_8 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_9 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33</td><td headers="hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_10 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_11 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 5.00 higher (1.87 lower to 11.87 higher)</td><td headers="hd_h_ch6.appf.tab8_1_1_1_4 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab8_1_1_1_5 hd_b_ch6.appf.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_1 hd_h_ch6.appf.tab8_1_1_2_2 hd_h_ch6.appf.tab8_1_1_2_3 hd_h_ch6.appf.tab8_1_1_2_4 hd_h_ch6.appf.tab8_1_1_2_5 hd_h_ch6.appf.tab8_1_1_2_6 hd_h_ch6.appf.tab8_1_1_2_7 hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_8 hd_h_ch6.appf.tab8_1_1_2_9 hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_10 hd_h_ch6.appf.tab8_1_1_2_11 hd_h_ch6.appf.tab8_1_1_1_4 hd_h_ch6.appf.tab8_1_1_1_5" id="hd_b_ch6.appf.tab8_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, DSM-IV checklist, 0-54, high is poor, CS, PT <3 months) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_1 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_2 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_3 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab8_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_4 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_5 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_6 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab8_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_7 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_8 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_9 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33</td><td headers="hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_10 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_11 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.83 lower (7.52 lower to 5.86 higher)</td><td headers="hd_h_ch6.appf.tab8_1_1_1_4 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab8_1_1_1_5 hd_b_ch6.appf.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_1 hd_h_ch6.appf.tab8_1_1_2_2 hd_h_ch6.appf.tab8_1_1_2_3 hd_h_ch6.appf.tab8_1_1_2_4 hd_h_ch6.appf.tab8_1_1_2_5 hd_h_ch6.appf.tab8_1_1_2_6 hd_h_ch6.appf.tab8_1_1_2_7 hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_8 hd_h_ch6.appf.tab8_1_1_2_9 hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_10 hd_h_ch6.appf.tab8_1_1_2_11 hd_h_ch6.appf.tab8_1_1_1_4 hd_h_ch6.appf.tab8_1_1_1_5" id="hd_b_ch6.appf.tab8_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months) (follow-up 12 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_1 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_2 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_3 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab8_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_4 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_5 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_6 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab8_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab8_1_1_1_1 hd_h_ch6.appf.tab8_1_1_2_7 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_8 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>17/32</p>
|
||
<p>(53.1%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab8_1_1_1_2 hd_h_ch6.appf.tab8_1_1_2_9 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60.6%</td><td headers="hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_10 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.88 (0.57 to 1.34)</td><td headers="hd_h_ch6.appf.tab8_1_1_1_3 hd_h_ch6.appf.tab8_1_1_2_11 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">73 fewer per 1000 (from 261 fewer to 206 more)</td><td headers="hd_h_ch6.appf.tab8_1_1_1_4 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab8_1_1_1_5 hd_b_ch6.appf.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab8_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab8_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>3</dt><dd><div id="ch6.appf.tab8_3"><p class="no_margin">Downgraded by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab9" class="table"><h3><span class="label">Table 57</span><span class="title">Clinical evidence profile: Stimulants + NF versus NF for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab9/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab9_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab9_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab9_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab9_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab9_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab9_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab9_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab9_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1" id="hd_h_ch6.appf.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab9_1_1_1_1" id="hd_h_ch6.appf.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab9_1_1_1_1" id="hd_h_ch6.appf.tab9_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab9_1_1_1_1" id="hd_h_ch6.appf.tab9_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab9_1_1_1_1" id="hd_h_ch6.appf.tab9_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab9_1_1_1_1" id="hd_h_ch6.appf.tab9_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab9_1_1_1_1" id="hd_h_ch6.appf.tab9_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab9_1_1_1_2" id="hd_h_ch6.appf.tab9_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + NF</th><th headers="hd_h_ch6.appf.tab9_1_1_1_2" id="hd_h_ch6.appf.tab9_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NF</th><th headers="hd_h_ch6.appf.tab9_1_1_1_3" id="hd_h_ch6.appf.tab9_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab9_1_1_1_3" id="hd_h_ch6.appf.tab9_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.10 higher (3.03 lower to 5.23 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.10 lower (6.01 lower to 3.81 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 higher (5.87 lower to 6.07 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.20 lower (8.73 lower to 2.33 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 higher (2.21 lower to 2.81 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.90 higher (2.00 lower to 3.80 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.10 lower (6.03 lower to 1.83 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<a class="bk_pop" href="#ch6.r3"><sup>3</sup></a></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.00 higher (3.24 lower to 3.24 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.20 higher (0.36 lower to 2.76 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is poor, PT, >3 months) (follow-up 6 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 higher (1.18 lower to 1.38 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.40 lower (2 lower to 1.2 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.80 higher (1.71 lower to 3.31 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_25_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.10 lower (4.79 lower to 0.59 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_27_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.20 higher (0.78 lower to 5.18 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_29_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.20 lower (6.17 to 0.23 lower)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_31_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 lower (1.42 lower to 1.02 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_33_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.30 higher (0.22 to 2.38 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_35_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.60 lower (1.88 lower to 0.68 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_37_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <3 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">22</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.50 lower (4.31 to 0.69 lower)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_39_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.20 higher (0.36 lower to 2.76 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_h_ch6.appf.tab9_1_1_2_3 hd_h_ch6.appf.tab9_1_1_2_4 hd_h_ch6.appf.tab9_1_1_2_5 hd_h_ch6.appf.tab9_1_1_2_6 hd_h_ch6.appf.tab9_1_1_2_7 hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_h_ch6.appf.tab9_1_1_2_9 hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_h_ch6.appf.tab9_1_1_2_11 hd_h_ch6.appf.tab9_1_1_1_4 hd_h_ch6.appf.tab9_1_1_1_5" id="hd_b_ch6.appf.tab9_1_1_41_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ,1-10, high is good, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_1 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_2 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_3 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab9_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_4 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_5 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_6 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision<sup><a class="bk_pop" href="#ch6.appf.tab9_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab9_1_1_1_1 hd_h_ch6.appf.tab9_1_1_2_7 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_8 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab9_1_1_1_2 hd_h_ch6.appf.tab9_1_1_2_9 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_10 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab9_1_1_1_3 hd_h_ch6.appf.tab9_1_1_2_11 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 higher (1.18 lower to 1.38 higher)</td><td headers="hd_h_ch6.appf.tab9_1_1_1_4 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab9_1_1_1_5 hd_b_ch6.appf.tab9_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab9_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab9_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab10" class="table"><h3><span class="label">Table 58</span><span class="title">Clinical evidence profile: Stimulants + CBT versus CBT for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab10/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab10_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.appf.tab10_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab10_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab10_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab10_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab10_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab10_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab10_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab10_1_1_1_1" id="hd_h_ch6.appf.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab10_1_1_1_1" id="hd_h_ch6.appf.tab10_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab10_1_1_1_1" id="hd_h_ch6.appf.tab10_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab10_1_1_1_1" id="hd_h_ch6.appf.tab10_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab10_1_1_1_1" id="hd_h_ch6.appf.tab10_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab10_1_1_1_1" id="hd_h_ch6.appf.tab10_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab10_1_1_1_1" id="hd_h_ch6.appf.tab10_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab10_1_1_1_2" id="hd_h_ch6.appf.tab10_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + CBT</th><th headers="hd_h_ch6.appf.tab10_1_1_1_2" id="hd_h_ch6.appf.tab10_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CBT</th><th headers="hd_h_ch6.appf.tab10_1_1_1_3" id="hd_h_ch6.appf.tab10_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab10_1_1_1_3" id="hd_h_ch6.appf.tab10_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab10_1_1_1_1 hd_h_ch6.appf.tab10_1_1_2_1 hd_h_ch6.appf.tab10_1_1_2_2 hd_h_ch6.appf.tab10_1_1_2_3 hd_h_ch6.appf.tab10_1_1_2_4 hd_h_ch6.appf.tab10_1_1_2_5 hd_h_ch6.appf.tab10_1_1_2_6 hd_h_ch6.appf.tab10_1_1_2_7 hd_h_ch6.appf.tab10_1_1_1_2 hd_h_ch6.appf.tab10_1_1_2_8 hd_h_ch6.appf.tab10_1_1_2_9 hd_h_ch6.appf.tab10_1_1_1_3 hd_h_ch6.appf.tab10_1_1_2_10 hd_h_ch6.appf.tab10_1_1_2_11 hd_h_ch6.appf.tab10_1_1_1_4 hd_h_ch6.appf.tab10_1_1_1_5" id="hd_b_ch6.appf.tab10_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, ADHD-RS, 0-68, high is poor, FV, PT, >3 months) (follow-up 16 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab10_1_1_1_1 hd_h_ch6.appf.tab10_1_1_2_1 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab10_1_1_1_1 hd_h_ch6.appf.tab10_1_1_2_2 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab10_1_1_1_1 hd_h_ch6.appf.tab10_1_1_2_3 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab10_1_1_1_1 hd_h_ch6.appf.tab10_1_1_2_4 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab10_1_1_1_1 hd_h_ch6.appf.tab10_1_1_2_5 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab10_1_1_1_1 hd_h_ch6.appf.tab10_1_1_2_6 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab10_1_1_1_1 hd_h_ch6.appf.tab10_1_1_2_7 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab10_1_1_1_2 hd_h_ch6.appf.tab10_1_1_2_8 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">151</td><td headers="hd_h_ch6.appf.tab10_1_1_1_2 hd_h_ch6.appf.tab10_1_1_2_9 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">152</td><td headers="hd_h_ch6.appf.tab10_1_1_1_3 hd_h_ch6.appf.tab10_1_1_2_10 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab10_1_1_1_3 hd_h_ch6.appf.tab10_1_1_2_11 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.60 higher (1.04 lower to 2.24 higher)</td><td headers="hd_h_ch6.appf.tab10_1_1_1_4 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁⨁</p>
|
||
<p>HIGH</p>
|
||
</td><td headers="hd_h_ch6.appf.tab10_1_1_1_5 hd_b_ch6.appf.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div></div><div id="ch6.appf.tab11" class="table"><h3><span class="label">Table 59</span><span class="title">Clinical evidence profile: Mixed medication + PT/FT versus PT/FT for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab11/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab11_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab11_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab11_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab11_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab11_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab11_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab11_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab11_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1" id="hd_h_ch6.appf.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab11_1_1_1_1" id="hd_h_ch6.appf.tab11_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab11_1_1_1_1" id="hd_h_ch6.appf.tab11_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab11_1_1_1_1" id="hd_h_ch6.appf.tab11_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab11_1_1_1_1" id="hd_h_ch6.appf.tab11_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab11_1_1_1_1" id="hd_h_ch6.appf.tab11_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab11_1_1_1_1" id="hd_h_ch6.appf.tab11_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab11_1_1_1_2" id="hd_h_ch6.appf.tab11_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication + PT/FT</th><th headers="hd_h_ch6.appf.tab11_1_1_1_2" id="hd_h_ch6.appf.tab11_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">PT/FT</th><th headers="hd_h_ch6.appf.tab11_1_1_1_3" id="hd_h_ch6.appf.tab11_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab11_1_1_1_3" id="hd_h_ch6.appf.tab11_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.07 lower (0.21 lower to 0.07 higher)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">119</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.35 lower (0.53 to 0.17 lower)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">133</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">129</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.61 higher (0.45 to 0.77 higher)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">114</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">107</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.08 lower (0.14 to 0.02 lower)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">133</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">129</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.38 lower (0.54 to 0.22 lower)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">120</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.35 lower (0.54 to 0.16 lower)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months) (follow-up 8 days; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab11_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.99 lower (3.42 lower to 1.44 higher)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab11_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">136</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 higher (3.4 lower to 3.8 higher)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab11_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.17 lower (4.34 lower to 2 higher)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">136</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.20 higher (0.39 lower to 6.79 higher)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_h_ch6.appf.tab11_1_1_2_3 hd_h_ch6.appf.tab11_1_1_2_4 hd_h_ch6.appf.tab11_1_1_2_5 hd_h_ch6.appf.tab11_1_1_2_6 hd_h_ch6.appf.tab11_1_1_2_7 hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_h_ch6.appf.tab11_1_1_2_9 hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_h_ch6.appf.tab11_1_1_2_11 hd_h_ch6.appf.tab11_1_1_1_4 hd_h_ch6.appf.tab11_1_1_1_5" id="hd_b_ch6.appf.tab11_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_1 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_2 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_3 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab11_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_4 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_5 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_6 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab11_1_1_1_1 hd_h_ch6.appf.tab11_1_1_2_7 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_8 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab11_1_1_1_2 hd_h_ch6.appf.tab11_1_1_2_9 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_10 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab11_1_1_1_3 hd_h_ch6.appf.tab11_1_1_2_11 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.60 lower (4.02 lower to 2.82 higher)</td><td headers="hd_h_ch6.appf.tab11_1_1_1_4 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab11_1_1_1_5 hd_b_ch6.appf.tab11_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab11_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab11_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>3</dt><dd><div id="ch6.appf.tab11_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div id="ch6.appf.s1.3"><h5>COMBINATION versus DRUGS</h5><div id="ch6.appf.tab12" class="table"><h3><span class="label">Table 60</span><span class="title">Clinical evidence profile: Atomoxetine + PT/FT versus atomoxetine for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab12/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab12_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab12_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab12_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab12_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab12_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab12_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab12_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab12_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1" id="hd_h_ch6.appf.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab12_1_1_1_1" id="hd_h_ch6.appf.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab12_1_1_1_1" id="hd_h_ch6.appf.tab12_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab12_1_1_1_1" id="hd_h_ch6.appf.tab12_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab12_1_1_1_1" id="hd_h_ch6.appf.tab12_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab12_1_1_1_1" id="hd_h_ch6.appf.tab12_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab12_1_1_1_1" id="hd_h_ch6.appf.tab12_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab12_1_1_1_2" id="hd_h_ch6.appf.tab12_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Atomoxetine + PT/FT</th><th headers="hd_h_ch6.appf.tab12_1_1_1_2" id="hd_h_ch6.appf.tab12_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Atomoxetine</th><th headers="hd_h_ch6.appf.tab12_1_1_1_3" id="hd_h_ch6.appf.tab12_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab12_1_1_1_3" id="hd_h_ch6.appf.tab12_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_h_ch6.appf.tab12_1_1_2_3 hd_h_ch6.appf.tab12_1_1_2_4 hd_h_ch6.appf.tab12_1_1_2_5 hd_h_ch6.appf.tab12_1_1_2_6 hd_h_ch6.appf.tab12_1_1_2_7 hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_h_ch6.appf.tab12_1_1_2_9 hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_h_ch6.appf.tab12_1_1_2_11 hd_h_ch6.appf.tab12_1_1_1_4 hd_h_ch6.appf.tab12_1_1_1_5" id="hd_b_ch6.appf.tab12_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_3 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_4 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_5 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_6 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab12_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_7 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_9 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_11 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.01 lower (0.32 lower to 0.3 higher)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_4 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_5 hd_b_ch6.appf.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_h_ch6.appf.tab12_1_1_2_3 hd_h_ch6.appf.tab12_1_1_2_4 hd_h_ch6.appf.tab12_1_1_2_5 hd_h_ch6.appf.tab12_1_1_2_6 hd_h_ch6.appf.tab12_1_1_2_7 hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_h_ch6.appf.tab12_1_1_2_9 hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_h_ch6.appf.tab12_1_1_2_11 hd_h_ch6.appf.tab12_1_1_1_4 hd_h_ch6.appf.tab12_1_1_1_5" id="hd_b_ch6.appf.tab12_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_3 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_4 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_5 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_6 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab12_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_7 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_9 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_11 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.35 lower (0.73 lower to 0.03 higher)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_4 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_5 hd_b_ch6.appf.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_h_ch6.appf.tab12_1_1_2_3 hd_h_ch6.appf.tab12_1_1_2_4 hd_h_ch6.appf.tab12_1_1_2_5 hd_h_ch6.appf.tab12_1_1_2_6 hd_h_ch6.appf.tab12_1_1_2_7 hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_h_ch6.appf.tab12_1_1_2_9 hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_h_ch6.appf.tab12_1_1_2_11 hd_h_ch6.appf.tab12_1_1_1_4 hd_h_ch6.appf.tab12_1_1_1_5" id="hd_b_ch6.appf.tab12_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, multiple scales, higher is worse, FV, PT <3 months) (follow-up 8-10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_3 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_4 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_5 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_6 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab12_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_7 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">61</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_9 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_11 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.21 lower (0.57 lower to 0.15 higher)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_4 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_5 hd_b_ch6.appf.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_h_ch6.appf.tab12_1_1_2_3 hd_h_ch6.appf.tab12_1_1_2_4 hd_h_ch6.appf.tab12_1_1_2_5 hd_h_ch6.appf.tab12_1_1_2_6 hd_h_ch6.appf.tab12_1_1_2_7 hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_h_ch6.appf.tab12_1_1_2_9 hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_h_ch6.appf.tab12_1_1_2_11 hd_h_ch6.appf.tab12_1_1_1_4 hd_h_ch6.appf.tab12_1_1_1_5" id="hd_b_ch6.appf.tab12_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, multiple scales, higher is worse, FV, PT <3 months) (follow-up 8-10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_3 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_4 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_5 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_6 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab12_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_7 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">61</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_9 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_11 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.16 lower (0.52 lower to 0.2 higher)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_4 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_5 hd_b_ch6.appf.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_h_ch6.appf.tab12_1_1_2_3 hd_h_ch6.appf.tab12_1_1_2_4 hd_h_ch6.appf.tab12_1_1_2_5 hd_h_ch6.appf.tab12_1_1_2_6 hd_h_ch6.appf.tab12_1_1_2_7 hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_h_ch6.appf.tab12_1_1_2_9 hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_h_ch6.appf.tab12_1_1_2_11 hd_h_ch6.appf.tab12_1_1_1_4 hd_h_ch6.appf.tab12_1_1_1_5" id="hd_b_ch6.appf.tab12_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, multiple scales, higher is worse, FV, PT <3 months) (follow-up 8-10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_3 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_4 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_5 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_6 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab12_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_7 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">61</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_9 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_11 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.37 lower (0.73 to 0.01 lower)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_4 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_5 hd_b_ch6.appf.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_h_ch6.appf.tab12_1_1_2_3 hd_h_ch6.appf.tab12_1_1_2_4 hd_h_ch6.appf.tab12_1_1_2_5 hd_h_ch6.appf.tab12_1_1_2_6 hd_h_ch6.appf.tab12_1_1_2_7 hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_h_ch6.appf.tab12_1_1_2_9 hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_h_ch6.appf.tab12_1_1_2_11 hd_h_ch6.appf.tab12_1_1_1_4 hd_h_ch6.appf.tab12_1_1_1_5" id="hd_b_ch6.appf.tab12_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, multiple scales, higher is worse, FV, PT <3 months) (follow-up 8-10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_3 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_4 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_5 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_6 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab12_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_7 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">61</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_9 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_11 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.38 lower (0.74 to 0.02 lower)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_4 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_5 hd_b_ch6.appf.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_h_ch6.appf.tab12_1_1_2_3 hd_h_ch6.appf.tab12_1_1_2_4 hd_h_ch6.appf.tab12_1_1_2_5 hd_h_ch6.appf.tab12_1_1_2_6 hd_h_ch6.appf.tab12_1_1_2_7 hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_h_ch6.appf.tab12_1_1_2_9 hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_h_ch6.appf.tab12_1_1_2_11 hd_h_ch6.appf.tab12_1_1_1_4 hd_h_ch6.appf.tab12_1_1_1_5" id="hd_b_ch6.appf.tab12_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months) (follow-up 8-10 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_3 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_4 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_5 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_6 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_7 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>31/60</p>
|
||
<p>(51.7%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_9 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49.4%</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 1.05 (0.73 to 1.5)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_11 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25 more per 1000 (from 133 fewer to 247 more)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_4 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_5 hd_b_ch6.appf.tab12_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_h_ch6.appf.tab12_1_1_2_3 hd_h_ch6.appf.tab12_1_1_2_4 hd_h_ch6.appf.tab12_1_1_2_5 hd_h_ch6.appf.tab12_1_1_2_6 hd_h_ch6.appf.tab12_1_1_2_7 hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_h_ch6.appf.tab12_1_1_2_9 hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_h_ch6.appf.tab12_1_1_2_11 hd_h_ch6.appf.tab12_1_1_1_4 hd_h_ch6.appf.tab12_1_1_1_5" id="hd_b_ch6.appf.tab12_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (behaviour, 0-100, high is good, teacher, PT, <3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_1 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_2 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_3 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab12_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_4 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_5 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_6 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab12_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab12_1_1_1_1 hd_h_ch6.appf.tab12_1_1_2_7 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_8 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab12_1_1_1_2 hd_h_ch6.appf.tab12_1_1_2_9 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_10 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab12_1_1_1_3 hd_h_ch6.appf.tab12_1_1_2_11 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 5.06 higher (4.59 lower to 14.71 higher)</td><td headers="hd_h_ch6.appf.tab12_1_1_1_4 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab12_1_1_1_5 hd_b_ch6.appf.tab12_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab12_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab12_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>3</dt><dd><div id="ch6.appf.tab12_3"><p class="no_margin">Downgraded by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab13" class="table"><h3><span class="label">Table 61</span><span class="title">Clinical evidence profile: Stimulants + PT/FT versus stimulants for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab13/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab13_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab13_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab13_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab13_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab13_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab13_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab13_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab13_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1" id="hd_h_ch6.appf.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab13_1_1_1_1" id="hd_h_ch6.appf.tab13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab13_1_1_1_1" id="hd_h_ch6.appf.tab13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab13_1_1_1_1" id="hd_h_ch6.appf.tab13_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab13_1_1_1_1" id="hd_h_ch6.appf.tab13_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab13_1_1_1_1" id="hd_h_ch6.appf.tab13_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab13_1_1_1_1" id="hd_h_ch6.appf.tab13_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab13_1_1_1_2" id="hd_h_ch6.appf.tab13_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + PT/FT</th><th headers="hd_h_ch6.appf.tab13_1_1_1_2" id="hd_h_ch6.appf.tab13_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants</th><th headers="hd_h_ch6.appf.tab13_1_1_1_3" id="hd_h_ch6.appf.tab13_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab13_1_1_1_3" id="hd_h_ch6.appf.tab13_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, multiple scales, high is poor, FV, PT, >3 months) (follow-up 2-12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">120</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">104</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.42 lower (0.69 to 0.15 lower)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SWAN, 0-3, high is poor, FV, FU, >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">44</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.13 lower (0.39 lower to 0.13 higher)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, DBDRS, 0-54, high is poor, FV, PT, <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">21</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.15 higher (3.48 lower to 7.78 higher)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, FBB-ADHS, 0-3, high is poor, FV, PT, >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">51</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">86</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.05 lower (0.35 lower to 0.25 higher)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab13_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 lower (0.36 lower to 0.16 higher)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab13_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 lower (0.7 lower to 0.1 higher)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab13_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 lower (0.46 lower to 0.26 higher)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, FBB-ADHS, 0-3, high is poor, FV, PT, >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">51</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.29 lower (0.53 to 0.05 lower)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_h_ch6.appf.tab13_1_1_2_3 hd_h_ch6.appf.tab13_1_1_2_4 hd_h_ch6.appf.tab13_1_1_2_5 hd_h_ch6.appf.tab13_1_1_2_6 hd_h_ch6.appf.tab13_1_1_2_7 hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_h_ch6.appf.tab13_1_1_2_9 hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_h_ch6.appf.tab13_1_1_2_11 hd_h_ch6.appf.tab13_1_1_1_4 hd_h_ch6.appf.tab13_1_1_1_5" id="hd_b_ch6.appf.tab13_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (function, parent, WFIRS-P, 0-3, high is poor, FV, PT, >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_1 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_2 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_3 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_4 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_5 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_6 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab13_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab13_1_1_1_1 hd_h_ch6.appf.tab13_1_1_2_7 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_8 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">51</td><td headers="hd_h_ch6.appf.tab13_1_1_1_2 hd_h_ch6.appf.tab13_1_1_2_9 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_10 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab13_1_1_1_3 hd_h_ch6.appf.tab13_1_1_2_11 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 lower (0.3 lower to 0.1 higher)</td><td headers="hd_h_ch6.appf.tab13_1_1_1_4 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab13_1_1_1_5 hd_b_ch6.appf.tab13_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab13_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab13_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>3</dt><dd><div id="ch6.appf.tab13_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab14" class="table"><h3><span class="label">Table 62</span><span class="title">Clinical evidence profile: Stimulants + PT/FT versus stimulants + NSST for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab14/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab14_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab14_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab14_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab14_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab14_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab14_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab14_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab14_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab14_1_1_1_1" id="hd_h_ch6.appf.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab14_1_1_1_1" id="hd_h_ch6.appf.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab14_1_1_1_1" id="hd_h_ch6.appf.tab14_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab14_1_1_1_1" id="hd_h_ch6.appf.tab14_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab14_1_1_1_1" id="hd_h_ch6.appf.tab14_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab14_1_1_1_1" id="hd_h_ch6.appf.tab14_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab14_1_1_1_1" id="hd_h_ch6.appf.tab14_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab14_1_1_1_2" id="hd_h_ch6.appf.tab14_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + PT/FT versus stimulants + NSST</th><th headers="hd_h_ch6.appf.tab14_1_1_1_2" id="hd_h_ch6.appf.tab14_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Control</th><th headers="hd_h_ch6.appf.tab14_1_1_1_3" id="hd_h_ch6.appf.tab14_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab14_1_1_1_3" id="hd_h_ch6.appf.tab14_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_1 hd_h_ch6.appf.tab14_1_1_2_2 hd_h_ch6.appf.tab14_1_1_2_3 hd_h_ch6.appf.tab14_1_1_2_4 hd_h_ch6.appf.tab14_1_1_2_5 hd_h_ch6.appf.tab14_1_1_2_6 hd_h_ch6.appf.tab14_1_1_2_7 hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_8 hd_h_ch6.appf.tab14_1_1_2_9 hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_10 hd_h_ch6.appf.tab14_1_1_2_11 hd_h_ch6.appf.tab14_1_1_1_4 hd_h_ch6.appf.tab14_1_1_1_5" id="hd_b_ch6.appf.tab14_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, PT >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_1 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_2 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_3 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab14_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_4 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_5 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_6 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab14_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_7 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_8 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_9 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_10 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_11 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 higher (0.08 lower to 0.48 higher)</td><td headers="hd_h_ch6.appf.tab14_1_1_1_4 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab14_1_1_1_5 hd_b_ch6.appf.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_1 hd_h_ch6.appf.tab14_1_1_2_2 hd_h_ch6.appf.tab14_1_1_2_3 hd_h_ch6.appf.tab14_1_1_2_4 hd_h_ch6.appf.tab14_1_1_2_5 hd_h_ch6.appf.tab14_1_1_2_6 hd_h_ch6.appf.tab14_1_1_2_7 hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_8 hd_h_ch6.appf.tab14_1_1_2_9 hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_10 hd_h_ch6.appf.tab14_1_1_2_11 hd_h_ch6.appf.tab14_1_1_1_4 hd_h_ch6.appf.tab14_1_1_1_5" id="hd_b_ch6.appf.tab14_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_1 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_2 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_3 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab14_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_4 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_5 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_6 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab14_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_7 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_8 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_9 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_10 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_11 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 higher (0.11 lower to 0.31 higher)</td><td headers="hd_h_ch6.appf.tab14_1_1_1_4 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab14_1_1_1_5 hd_b_ch6.appf.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_1 hd_h_ch6.appf.tab14_1_1_2_2 hd_h_ch6.appf.tab14_1_1_2_3 hd_h_ch6.appf.tab14_1_1_2_4 hd_h_ch6.appf.tab14_1_1_2_5 hd_h_ch6.appf.tab14_1_1_2_6 hd_h_ch6.appf.tab14_1_1_2_7 hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_8 hd_h_ch6.appf.tab14_1_1_2_9 hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_10 hd_h_ch6.appf.tab14_1_1_2_11 hd_h_ch6.appf.tab14_1_1_1_4 hd_h_ch6.appf.tab14_1_1_1_5" id="hd_b_ch6.appf.tab14_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_1 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_2 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_3 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab14_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_4 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_5 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_6 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_7 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_8 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_9 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_10 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_11 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0 higher (0.36 lower to 0.36 higher)</td><td headers="hd_h_ch6.appf.tab14_1_1_1_4 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab14_1_1_1_5 hd_b_ch6.appf.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_1 hd_h_ch6.appf.tab14_1_1_2_2 hd_h_ch6.appf.tab14_1_1_2_3 hd_h_ch6.appf.tab14_1_1_2_4 hd_h_ch6.appf.tab14_1_1_2_5 hd_h_ch6.appf.tab14_1_1_2_6 hd_h_ch6.appf.tab14_1_1_2_7 hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_8 hd_h_ch6.appf.tab14_1_1_2_9 hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_10 hd_h_ch6.appf.tab14_1_1_2_11 hd_h_ch6.appf.tab14_1_1_1_4 hd_h_ch6.appf.tab14_1_1_1_5" id="hd_b_ch6.appf.tab14_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_1 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_2 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_3 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab14_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_4 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_5 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_6 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab14_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab14_1_1_1_1 hd_h_ch6.appf.tab14_1_1_2_7 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_8 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab14_1_1_1_2 hd_h_ch6.appf.tab14_1_1_2_9 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_10 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab14_1_1_1_3 hd_h_ch6.appf.tab14_1_1_2_11 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 higher (0.03 to 0.57 higher)</td><td headers="hd_h_ch6.appf.tab14_1_1_1_4 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab14_1_1_1_5 hd_b_ch6.appf.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab14_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab14_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab15" class="table"><h3><span class="label">Table 63</span><span class="title">Clinical evidence profile: Stimulants + attention/memory/cognitive training versus stimulants for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab15/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab15_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab15_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab15_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab15_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab15_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab15_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab15_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab15_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab15_1_1_1_1" id="hd_h_ch6.appf.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab15_1_1_1_1" id="hd_h_ch6.appf.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab15_1_1_1_1" id="hd_h_ch6.appf.tab15_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab15_1_1_1_1" id="hd_h_ch6.appf.tab15_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab15_1_1_1_1" id="hd_h_ch6.appf.tab15_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab15_1_1_1_1" id="hd_h_ch6.appf.tab15_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab15_1_1_1_1" id="hd_h_ch6.appf.tab15_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab15_1_1_1_2" id="hd_h_ch6.appf.tab15_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + attention/memory/cognitive training</th><th headers="hd_h_ch6.appf.tab15_1_1_1_2" id="hd_h_ch6.appf.tab15_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants</th><th headers="hd_h_ch6.appf.tab15_1_1_1_3" id="hd_h_ch6.appf.tab15_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab15_1_1_1_3" id="hd_h_ch6.appf.tab15_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab15_1_1_1_1 hd_h_ch6.appf.tab15_1_1_2_1 hd_h_ch6.appf.tab15_1_1_2_2 hd_h_ch6.appf.tab15_1_1_2_3 hd_h_ch6.appf.tab15_1_1_2_4 hd_h_ch6.appf.tab15_1_1_2_5 hd_h_ch6.appf.tab15_1_1_2_6 hd_h_ch6.appf.tab15_1_1_2_7 hd_h_ch6.appf.tab15_1_1_1_2 hd_h_ch6.appf.tab15_1_1_2_8 hd_h_ch6.appf.tab15_1_1_2_9 hd_h_ch6.appf.tab15_1_1_1_3 hd_h_ch6.appf.tab15_1_1_2_10 hd_h_ch6.appf.tab15_1_1_2_11 hd_h_ch6.appf.tab15_1_1_1_4 hd_h_ch6.appf.tab15_1_1_1_5" id="hd_b_ch6.appf.tab15_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Conners 48, 0-70, high is poor, FV, <3 months PT) (follow-up <3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab15_1_1_1_1 hd_h_ch6.appf.tab15_1_1_2_1 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab15_1_1_1_1 hd_h_ch6.appf.tab15_1_1_2_2 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab15_1_1_1_1 hd_h_ch6.appf.tab15_1_1_2_3 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab15_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab15_1_1_1_1 hd_h_ch6.appf.tab15_1_1_2_4 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab15_1_1_1_1 hd_h_ch6.appf.tab15_1_1_2_5 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab15_1_1_1_1 hd_h_ch6.appf.tab15_1_1_2_6 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab15_1_1_1_1 hd_h_ch6.appf.tab15_1_1_2_7 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab15_1_1_1_2 hd_h_ch6.appf.tab15_1_1_2_8 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">23</td><td headers="hd_h_ch6.appf.tab15_1_1_1_2 hd_h_ch6.appf.tab15_1_1_2_9 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab15_1_1_1_3 hd_h_ch6.appf.tab15_1_1_2_10 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab15_1_1_1_3 hd_h_ch6.appf.tab15_1_1_2_11 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 8.67 lower (11.5 to 5.84 lower)</td><td headers="hd_h_ch6.appf.tab15_1_1_1_4 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab15_1_1_1_5 hd_b_ch6.appf.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab15_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab16" class="table"><h3><span class="label">Table 64</span><span class="title">Clinical evidence profile: Stimulants + NF versus stimulants for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab16/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab16_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab16_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab16_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab16_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab16_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab16_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab16_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab16_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1" id="hd_h_ch6.appf.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab16_1_1_1_1" id="hd_h_ch6.appf.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab16_1_1_1_1" id="hd_h_ch6.appf.tab16_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab16_1_1_1_1" id="hd_h_ch6.appf.tab16_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab16_1_1_1_1" id="hd_h_ch6.appf.tab16_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab16_1_1_1_1" id="hd_h_ch6.appf.tab16_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab16_1_1_1_1" id="hd_h_ch6.appf.tab16_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab16_1_1_1_2" id="hd_h_ch6.appf.tab16_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + NF</th><th headers="hd_h_ch6.appf.tab16_1_1_1_2" id="hd_h_ch6.appf.tab16_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants</th><th headers="hd_h_ch6.appf.tab16_1_1_1_3" id="hd_h_ch6.appf.tab16_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab16_1_1_1_3" id="hd_h_ch6.appf.tab16_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.50 lower (7.57 lower to 0.57 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">0</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.80 lower (5.67 lower to 4.07 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.60 lower (8.51 lower to 3.31 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.00 lower (9.55 lower to 1.55 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.70 lower (5.14 to 0.26 lower)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.50 lower (3.27 lower to 2.27 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.50 lower (6.37 lower to 1.37 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.50 lower (5.64 lower to 2.64 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.60 higher (0.83 lower to 2.03 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<a class="bk_pop" href="#ch6.r3"><sup>3</sup></a></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.00 higher (1.22 lower to 1.22 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 lower (1.87 lower to 1.27 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.80 lower (3.05 lower to 1.45 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_25_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 lower (2.94 lower to 0 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_27_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 lower (3.16 lower to 2.96 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_29_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.50 lower (4.48 lower to 1.48 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_31_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is poor, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.40 lower (1.62 lower to 0.82 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_33_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is poor, PT, >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.90 higher (0.18 lower to 1.98 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_35_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 lower (1.58 lower to 1.18 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_37_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months) (follow-up <3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">22</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.10 lower (2.84 lower to 0.64 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_39_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab16_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.60 higher (0.83 lower to 2.03 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_h_ch6.appf.tab16_1_1_2_3 hd_h_ch6.appf.tab16_1_1_2_4 hd_h_ch6.appf.tab16_1_1_2_5 hd_h_ch6.appf.tab16_1_1_2_6 hd_h_ch6.appf.tab16_1_1_2_7 hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_h_ch6.appf.tab16_1_1_2_9 hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_h_ch6.appf.tab16_1_1_2_11 hd_h_ch6.appf.tab16_1_1_1_4 hd_h_ch6.appf.tab16_1_1_1_5" id="hd_b_ch6.appf.tab16_1_1_41_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_1 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_2 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_3 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab16_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_4 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_5 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_6 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<a class="bk_pop" href="#ch6.r3"><sup>3</sup></a></td><td headers="hd_h_ch6.appf.tab16_1_1_1_1 hd_h_ch6.appf.tab16_1_1_2_7 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_8 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab16_1_1_1_2 hd_h_ch6.appf.tab16_1_1_2_9 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_10 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab16_1_1_1_3 hd_h_ch6.appf.tab16_1_1_2_11 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.00 higher (1.22 lower to 1.22 higher)</td><td headers="hd_h_ch6.appf.tab16_1_1_1_4 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab16_1_1_1_5 hd_b_ch6.appf.tab16_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab16_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab16_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab17" class="table"><h3><span class="label">Table 65</span><span class="title">Clinical evidence profile: Mixed medication + PT/FT versus mixed medication for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab17/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab17_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab17_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab17_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab17_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab17_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab17_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab17_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab17_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1" id="hd_h_ch6.appf.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab17_1_1_1_1" id="hd_h_ch6.appf.tab17_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab17_1_1_1_1" id="hd_h_ch6.appf.tab17_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab17_1_1_1_1" id="hd_h_ch6.appf.tab17_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab17_1_1_1_1" id="hd_h_ch6.appf.tab17_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab17_1_1_1_1" id="hd_h_ch6.appf.tab17_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab17_1_1_1_1" id="hd_h_ch6.appf.tab17_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab17_1_1_1_2" id="hd_h_ch6.appf.tab17_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication + PT/FT</th><th headers="hd_h_ch6.appf.tab17_1_1_1_2" id="hd_h_ch6.appf.tab17_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication</th><th headers="hd_h_ch6.appf.tab17_1_1_1_3" id="hd_h_ch6.appf.tab17_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab17_1_1_1_3" id="hd_h_ch6.appf.tab17_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">144</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">126</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.27 lower (0.51 to 0.03 lower)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">115</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.01 lower (0.15 lower to 0.13 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Conner’s, 0-20, high is poor, FV, PT, <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.22 higher (4.38 lower to 8.82 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, multiple scales, high is poor, FV, PT, >3 months) (follow-up 3-14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">162</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">147</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.05 lower (0.28 lower to 0.17 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">133</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">121</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.94 higher (0.78 to 1.1 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">114</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">110</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.05 higher (0 to 0.1 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">144</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">126</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.22 lower (0.46 lower to 0.02 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">133</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">121</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 lower (0.27 lower to 0.07 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">120</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.01 higher (0.18 lower to 0.2 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months) (follow-up 12 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">144</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">126</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.27 lower (0.51 to 0.03 lower)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (CBRS aggressive behaviour subscale, 0-15, high is poor, teacher, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.58 lower (8.11 lower to 4.95 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (CBRS aggressive behaviour subscale, 0-15, high is poor, teacher, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.28 lower (8.8 lower to 4.24 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_25_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (CBRS emotional distress subscale, 0-15, high is poor, teacher, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.22 higher (2.14 lower to 10.58 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_27_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (CBRS emotional distress subscale, 0-15, high is poor, teacher, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.35 higher (4.16 lower to 8.86 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_29_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.15 higher (0.15 to 6.15 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_31_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">136</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">124</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.80 higher (2.78 lower to 4.38 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_33_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.28 higher (0.3 to 8.26 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_33_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_35_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">136</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">124</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.50 higher (2.06 lower to 5.06 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_35_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_37_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, 0-132, high is better, FU >3 months) (follow-up median 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">115</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 lower (3.53 lower to 3.33 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_37_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_39_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (general, CBRS academic subscale, 0-30, high is poor, teacher, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.25 higher (4.95 lower to 9.45 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_39_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_h_ch6.appf.tab17_1_1_2_3 hd_h_ch6.appf.tab17_1_1_2_4 hd_h_ch6.appf.tab17_1_1_2_5 hd_h_ch6.appf.tab17_1_1_2_6 hd_h_ch6.appf.tab17_1_1_2_7 hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_h_ch6.appf.tab17_1_1_2_9 hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_h_ch6.appf.tab17_1_1_2_11 hd_h_ch6.appf.tab17_1_1_1_4 hd_h_ch6.appf.tab17_1_1_1_5" id="hd_b_ch6.appf.tab17_1_1_41_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (general, CBRS academic subscale, 0-30, high is poor, teacher, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_1 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_2 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_3 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab17_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_4 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_5 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_6 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab17_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab17_1_1_1_1 hd_h_ch6.appf.tab17_1_1_2_7 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_8 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26</td><td headers="hd_h_ch6.appf.tab17_1_1_1_2 hd_h_ch6.appf.tab17_1_1_2_9 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_10 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab17_1_1_1_3 hd_h_ch6.appf.tab17_1_1_2_11 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.48 lower (7.09 lower to 6.13 higher)</td><td headers="hd_h_ch6.appf.tab17_1_1_1_4 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab17_1_1_1_5 hd_b_ch6.appf.tab17_1_1_41_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab17_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab17_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>3</dt><dd><div id="ch6.appf.tab17_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab18" class="table"><h3><span class="label">Table 66</span><span class="title">Clinical evidence profile: Mixed medication + CBT versus mixed medication for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab18/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab18_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab18_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab18_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab18_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab18_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab18_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab18_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab18_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1" id="hd_h_ch6.appf.tab18_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab18_1_1_1_1" id="hd_h_ch6.appf.tab18_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab18_1_1_1_1" id="hd_h_ch6.appf.tab18_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab18_1_1_1_1" id="hd_h_ch6.appf.tab18_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab18_1_1_1_1" id="hd_h_ch6.appf.tab18_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab18_1_1_1_1" id="hd_h_ch6.appf.tab18_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab18_1_1_1_1" id="hd_h_ch6.appf.tab18_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab18_1_1_1_2" id="hd_h_ch6.appf.tab18_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication + CBT</th><th headers="hd_h_ch6.appf.tab18_1_1_1_2" id="hd_h_ch6.appf.tab18_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication</th><th headers="hd_h_ch6.appf.tab18_1_1_1_3" id="hd_h_ch6.appf.tab18_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab18_1_1_1_3" id="hd_h_ch6.appf.tab18_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_h_ch6.appf.tab18_1_1_2_3 hd_h_ch6.appf.tab18_1_1_2_4 hd_h_ch6.appf.tab18_1_1_2_5 hd_h_ch6.appf.tab18_1_1_2_6 hd_h_ch6.appf.tab18_1_1_2_7 hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_h_ch6.appf.tab18_1_1_2_9 hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_h_ch6.appf.tab18_1_1_2_11 hd_h_ch6.appf.tab18_1_1_1_4 hd_h_ch6.appf.tab18_1_1_1_5" id="hd_b_ch6.appf.tab18_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, 0-54, high is poor, CS, PT >3 months) (follow-up 4 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_3 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab18_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_4 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_5 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_6 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_7 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">46</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_9 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">46</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_11 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 1.08 lower (1.52 to 0.64 lower)</td><td headers="hd_h_ch6.appf.tab18_1_1_1_4 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab18_1_1_1_5 hd_b_ch6.appf.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_h_ch6.appf.tab18_1_1_2_3 hd_h_ch6.appf.tab18_1_1_2_4 hd_h_ch6.appf.tab18_1_1_2_5 hd_h_ch6.appf.tab18_1_1_2_6 hd_h_ch6.appf.tab18_1_1_2_7 hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_h_ch6.appf.tab18_1_1_2_9 hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_h_ch6.appf.tab18_1_1_2_11 hd_h_ch6.appf.tab18_1_1_1_4 hd_h_ch6.appf.tab18_1_1_1_5" id="hd_b_ch6.appf.tab18_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months) (follow-up 12 sessions; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_3 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab18_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_4 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_5 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_6 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_7 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_9 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_11 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 7.62 lower (7.98 to 7.26 lower)</td><td headers="hd_h_ch6.appf.tab18_1_1_1_4 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab18_1_1_1_5 hd_b_ch6.appf.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_h_ch6.appf.tab18_1_1_2_3 hd_h_ch6.appf.tab18_1_1_2_4 hd_h_ch6.appf.tab18_1_1_2_5 hd_h_ch6.appf.tab18_1_1_2_6 hd_h_ch6.appf.tab18_1_1_2_7 hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_h_ch6.appf.tab18_1_1_2_9 hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_h_ch6.appf.tab18_1_1_2_11 hd_h_ch6.appf.tab18_1_1_1_4 hd_h_ch6.appf.tab18_1_1_1_5" id="hd_b_ch6.appf.tab18_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months) (follow-up 12 sessions; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_3 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab18_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_4 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_5 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_6 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_7 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_9 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_11 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 9.39 lower (9.79 to 8.99 lower)</td><td headers="hd_h_ch6.appf.tab18_1_1_1_4 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab18_1_1_1_5 hd_b_ch6.appf.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_h_ch6.appf.tab18_1_1_2_3 hd_h_ch6.appf.tab18_1_1_2_4 hd_h_ch6.appf.tab18_1_1_2_5 hd_h_ch6.appf.tab18_1_1_2_6 hd_h_ch6.appf.tab18_1_1_2_7 hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_h_ch6.appf.tab18_1_1_2_9 hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_h_ch6.appf.tab18_1_1_2_11 hd_h_ch6.appf.tab18_1_1_1_4 hd_h_ch6.appf.tab18_1_1_1_5" id="hd_b_ch6.appf.tab18_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months) (follow-up 4 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_3 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab18_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_4 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_5 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_6 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_7 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">46</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_9 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">46</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_11 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 2.21 lower (2.74 to 1.69 lower)</td><td headers="hd_h_ch6.appf.tab18_1_1_1_4 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab18_1_1_1_5 hd_b_ch6.appf.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_h_ch6.appf.tab18_1_1_2_3 hd_h_ch6.appf.tab18_1_1_2_4 hd_h_ch6.appf.tab18_1_1_2_5 hd_h_ch6.appf.tab18_1_1_2_6 hd_h_ch6.appf.tab18_1_1_2_7 hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_h_ch6.appf.tab18_1_1_2_9 hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_h_ch6.appf.tab18_1_1_2_11 hd_h_ch6.appf.tab18_1_1_1_4 hd_h_ch6.appf.tab18_1_1_1_5" id="hd_b_ch6.appf.tab18_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months) (follow-up 12 sessions; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_3 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab18_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_4 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_5 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_6 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_7 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_9 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_11 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.43 lower (3.74 to 3.12 lower)</td><td headers="hd_h_ch6.appf.tab18_1_1_1_4 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab18_1_1_1_5 hd_b_ch6.appf.tab18_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_h_ch6.appf.tab18_1_1_2_3 hd_h_ch6.appf.tab18_1_1_2_4 hd_h_ch6.appf.tab18_1_1_2_5 hd_h_ch6.appf.tab18_1_1_2_6 hd_h_ch6.appf.tab18_1_1_2_7 hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_h_ch6.appf.tab18_1_1_2_9 hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_h_ch6.appf.tab18_1_1_2_11 hd_h_ch6.appf.tab18_1_1_1_4 hd_h_ch6.appf.tab18_1_1_1_5" id="hd_b_ch6.appf.tab18_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months) (follow-up 12 sessions; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_3 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab18_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_4 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_5 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_6 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_7 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_9 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_11 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.84 lower (4.12 to 3.56 lower)</td><td headers="hd_h_ch6.appf.tab18_1_1_1_4 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab18_1_1_1_5 hd_b_ch6.appf.tab18_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_h_ch6.appf.tab18_1_1_2_3 hd_h_ch6.appf.tab18_1_1_2_4 hd_h_ch6.appf.tab18_1_1_2_5 hd_h_ch6.appf.tab18_1_1_2_6 hd_h_ch6.appf.tab18_1_1_2_7 hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_h_ch6.appf.tab18_1_1_2_9 hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_h_ch6.appf.tab18_1_1_2_11 hd_h_ch6.appf.tab18_1_1_1_4 hd_h_ch6.appf.tab18_1_1_1_5" id="hd_b_ch6.appf.tab18_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months) (follow-up 12 sessions; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_3 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab18_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_4 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_5 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_6 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_7 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_9 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_11 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.33 lower (4.51 to 4.15 lower)</td><td headers="hd_h_ch6.appf.tab18_1_1_1_4 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab18_1_1_1_5 hd_b_ch6.appf.tab18_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_h_ch6.appf.tab18_1_1_2_3 hd_h_ch6.appf.tab18_1_1_2_4 hd_h_ch6.appf.tab18_1_1_2_5 hd_h_ch6.appf.tab18_1_1_2_6 hd_h_ch6.appf.tab18_1_1_2_7 hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_h_ch6.appf.tab18_1_1_2_9 hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_h_ch6.appf.tab18_1_1_2_11 hd_h_ch6.appf.tab18_1_1_1_4 hd_h_ch6.appf.tab18_1_1_1_5" id="hd_b_ch6.appf.tab18_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months) (follow-up 12 sessions; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_1 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_2 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_3 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab18_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_4 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_5 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_6 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab18_1_1_1_1 hd_h_ch6.appf.tab18_1_1_2_7 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_8 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">59</td><td headers="hd_h_ch6.appf.tab18_1_1_1_2 hd_h_ch6.appf.tab18_1_1_2_9 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_10 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab18_1_1_1_3 hd_h_ch6.appf.tab18_1_1_2_11 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 5.68 lower (5.89 to 5.47 lower)</td><td headers="hd_h_ch6.appf.tab18_1_1_1_4 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab18_1_1_1_5 hd_b_ch6.appf.tab18_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab18_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab18_2"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab19" class="table"><h3><span class="label">Table 67</span><span class="title">Clinical evidence profile: Mixed medication + PE versus mixed medication + NSST for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab19/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab19_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab19_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab19_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab19_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab19_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab19_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab19_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab19_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1" id="hd_h_ch6.appf.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab19_1_1_1_1" id="hd_h_ch6.appf.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab19_1_1_1_1" id="hd_h_ch6.appf.tab19_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab19_1_1_1_1" id="hd_h_ch6.appf.tab19_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab19_1_1_1_1" id="hd_h_ch6.appf.tab19_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab19_1_1_1_1" id="hd_h_ch6.appf.tab19_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab19_1_1_1_1" id="hd_h_ch6.appf.tab19_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab19_1_1_1_2" id="hd_h_ch6.appf.tab19_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication + PE</th><th headers="hd_h_ch6.appf.tab19_1_1_1_2" id="hd_h_ch6.appf.tab19_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication + NSST</th><th headers="hd_h_ch6.appf.tab19_1_1_1_3" id="hd_h_ch6.appf.tab19_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab19_1_1_1_3" id="hd_h_ch6.appf.tab19_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_h_ch6.appf.tab19_1_1_2_3 hd_h_ch6.appf.tab19_1_1_2_4 hd_h_ch6.appf.tab19_1_1_2_5 hd_h_ch6.appf.tab19_1_1_2_6 hd_h_ch6.appf.tab19_1_1_2_7 hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_h_ch6.appf.tab19_1_1_2_9 hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_h_ch6.appf.tab19_1_1_2_11 hd_h_ch6.appf.tab19_1_1_1_4 hd_h_ch6.appf.tab19_1_1_1_5" id="hd_b_ch6.appf.tab19_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CPRS, 0-27, high is poor, FV, PT <3 months) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_3 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_4 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_5 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_6 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_7 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">42</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_9 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_11 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.71 lower (3.67 lower to 0.25 higher)</td><td headers="hd_h_ch6.appf.tab19_1_1_1_4 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab19_1_1_1_5 hd_b_ch6.appf.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_h_ch6.appf.tab19_1_1_2_3 hd_h_ch6.appf.tab19_1_1_2_4 hd_h_ch6.appf.tab19_1_1_2_5 hd_h_ch6.appf.tab19_1_1_2_6 hd_h_ch6.appf.tab19_1_1_2_7 hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_h_ch6.appf.tab19_1_1_2_9 hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_h_ch6.appf.tab19_1_1_2_11 hd_h_ch6.appf.tab19_1_1_1_4 hd_h_ch6.appf.tab19_1_1_1_5" id="hd_b_ch6.appf.tab19_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CPRS, 0-27, high is poor, FV, FU >3 months) (follow-up 64 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_3 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_4 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_5 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_6 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_7 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_9 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_11 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.07 lower (3.02 lower to 0.88 higher)</td><td headers="hd_h_ch6.appf.tab19_1_1_1_4 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab19_1_1_1_5 hd_b_ch6.appf.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_h_ch6.appf.tab19_1_1_2_3 hd_h_ch6.appf.tab19_1_1_2_4 hd_h_ch6.appf.tab19_1_1_2_5 hd_h_ch6.appf.tab19_1_1_2_6 hd_h_ch6.appf.tab19_1_1_2_7 hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_h_ch6.appf.tab19_1_1_2_9 hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_h_ch6.appf.tab19_1_1_2_11 hd_h_ch6.appf.tab19_1_1_1_4 hd_h_ch6.appf.tab19_1_1_1_5" id="hd_b_ch6.appf.tab19_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, CPRS, 0-27, high is poor, FV, PT <3 months) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_3 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_4 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_5 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_6 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_7 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">42</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_9 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_11 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.05 lower (4.63 to 1.47 lower)</td><td headers="hd_h_ch6.appf.tab19_1_1_1_4 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab19_1_1_1_5 hd_b_ch6.appf.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_h_ch6.appf.tab19_1_1_2_3 hd_h_ch6.appf.tab19_1_1_2_4 hd_h_ch6.appf.tab19_1_1_2_5 hd_h_ch6.appf.tab19_1_1_2_6 hd_h_ch6.appf.tab19_1_1_2_7 hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_h_ch6.appf.tab19_1_1_2_9 hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_h_ch6.appf.tab19_1_1_2_11 hd_h_ch6.appf.tab19_1_1_1_4 hd_h_ch6.appf.tab19_1_1_1_5" id="hd_b_ch6.appf.tab19_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, CPRS, 0-27, high is poor, FV, FU >3 months) (follow-up 64 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_3 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_4 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_5 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_6 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_7 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_9 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_11 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.15 lower (3.93 to 0.37 lower)</td><td headers="hd_h_ch6.appf.tab19_1_1_1_4 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab19_1_1_1_5 hd_b_ch6.appf.tab19_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_h_ch6.appf.tab19_1_1_2_3 hd_h_ch6.appf.tab19_1_1_2_4 hd_h_ch6.appf.tab19_1_1_2_5 hd_h_ch6.appf.tab19_1_1_2_6 hd_h_ch6.appf.tab19_1_1_2_7 hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_h_ch6.appf.tab19_1_1_2_9 hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_h_ch6.appf.tab19_1_1_2_11 hd_h_ch6.appf.tab19_1_1_1_4 hd_h_ch6.appf.tab19_1_1_1_5" id="hd_b_ch6.appf.tab19_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (opposition, parent, CPRS, 0-27, high is poor, FV, PT <3 months) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_3 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_4 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_5 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_6 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_7 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">42</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_9 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_11 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.23 lower (2.94 lower to 0.48 higher)</td><td headers="hd_h_ch6.appf.tab19_1_1_1_4 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab19_1_1_1_5 hd_b_ch6.appf.tab19_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_h_ch6.appf.tab19_1_1_2_3 hd_h_ch6.appf.tab19_1_1_2_4 hd_h_ch6.appf.tab19_1_1_2_5 hd_h_ch6.appf.tab19_1_1_2_6 hd_h_ch6.appf.tab19_1_1_2_7 hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_h_ch6.appf.tab19_1_1_2_9 hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_h_ch6.appf.tab19_1_1_2_11 hd_h_ch6.appf.tab19_1_1_1_4 hd_h_ch6.appf.tab19_1_1_1_5" id="hd_b_ch6.appf.tab19_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (opposition, parent, CPRS, 0-27, high is poor, FV, FU >3 months) (follow-up 64 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_3 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_4 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_5 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_6 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_7 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_9 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_11 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.43 lower (2.21 lower to 1.35 higher)</td><td headers="hd_h_ch6.appf.tab19_1_1_1_4 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab19_1_1_1_5 hd_b_ch6.appf.tab19_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_h_ch6.appf.tab19_1_1_2_3 hd_h_ch6.appf.tab19_1_1_2_4 hd_h_ch6.appf.tab19_1_1_2_5 hd_h_ch6.appf.tab19_1_1_2_6 hd_h_ch6.appf.tab19_1_1_2_7 hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_h_ch6.appf.tab19_1_1_2_9 hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_h_ch6.appf.tab19_1_1_2_11 hd_h_ch6.appf.tab19_1_1_1_4 hd_h_ch6.appf.tab19_1_1_1_5" id="hd_b_ch6.appf.tab19_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (SDQ, parent, 0-25, high is poor, FV, PT <3 months) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_3 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_4 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_5 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_6 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_7 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_9 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_11 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.11 lower (1.21 lower to 0.99 higher)</td><td headers="hd_h_ch6.appf.tab19_1_1_1_4 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab19_1_1_1_5 hd_b_ch6.appf.tab19_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_h_ch6.appf.tab19_1_1_2_3 hd_h_ch6.appf.tab19_1_1_2_4 hd_h_ch6.appf.tab19_1_1_2_5 hd_h_ch6.appf.tab19_1_1_2_6 hd_h_ch6.appf.tab19_1_1_2_7 hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_h_ch6.appf.tab19_1_1_2_9 hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_h_ch6.appf.tab19_1_1_2_11 hd_h_ch6.appf.tab19_1_1_1_4 hd_h_ch6.appf.tab19_1_1_1_5" id="hd_b_ch6.appf.tab19_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (SDQ, parent, 0-25, high is poor, FV, FU >3 months) (follow-up 64 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_1 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_2 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_3 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_4 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_5 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_6 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab19_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab19_1_1_1_1 hd_h_ch6.appf.tab19_1_1_2_7 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_8 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40</td><td headers="hd_h_ch6.appf.tab19_1_1_1_2 hd_h_ch6.appf.tab19_1_1_2_9 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_10 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab19_1_1_1_3 hd_h_ch6.appf.tab19_1_1_2_11 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.29 lower (1.32 lower to 0.74 higher)</td><td headers="hd_h_ch6.appf.tab19_1_1_1_4 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab19_1_1_1_5 hd_b_ch6.appf.tab19_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab19_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab19_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab20" class="table"><h3><span class="label">Table 68</span><span class="title">Clinical evidence profile: Mixed medication + sleep intervention versus mixed medication for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab20/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab20_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab20_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab20_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab20_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab20_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab20_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab20_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab20_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1" id="hd_h_ch6.appf.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab20_1_1_1_1" id="hd_h_ch6.appf.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab20_1_1_1_1" id="hd_h_ch6.appf.tab20_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab20_1_1_1_1" id="hd_h_ch6.appf.tab20_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab20_1_1_1_1" id="hd_h_ch6.appf.tab20_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab20_1_1_1_1" id="hd_h_ch6.appf.tab20_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab20_1_1_1_1" id="hd_h_ch6.appf.tab20_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab20_1_1_1_2" id="hd_h_ch6.appf.tab20_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication + sleep intervention</th><th headers="hd_h_ch6.appf.tab20_1_1_1_2" id="hd_h_ch6.appf.tab20_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication</th><th headers="hd_h_ch6.appf.tab20_1_1_1_3" id="hd_h_ch6.appf.tab20_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab20_1_1_1_3" id="hd_h_ch6.appf.tab20_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.21 lower (0.46 lower to 0.04 higher)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab20_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.39 lower (0.64 to 0.13 lower)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.18 lower (0.43 lower to 0.07 higher)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab20_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.41 lower (0.66 to 0.15 lower)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab20_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.28 lower (0.53 to 0.03 lower)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab20_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.27 lower (0.52 to 0.02 lower)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months) (follow-up 6 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.18 lower (0.44 lower to 0.07 higher)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab20_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.29 lower (0.54 to 0.04 lower)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.11 lower (0.36 lower to 0.14 higher)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months) (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab20_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.43 lower (0.68 to 0.18 lower)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.11 lower (0.36 lower to 0.14 higher)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab20_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.46 lower (0.72 to 0.21 lower)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_25_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (teacher, SDQ, 0-54, high is poor, CS, <3 months PT (follow-up 3 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.25 lower (0.5 lower to 0 higher)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_h_ch6.appf.tab20_1_1_2_3 hd_h_ch6.appf.tab20_1_1_2_4 hd_h_ch6.appf.tab20_1_1_2_5 hd_h_ch6.appf.tab20_1_1_2_6 hd_h_ch6.appf.tab20_1_1_2_7 hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_h_ch6.appf.tab20_1_1_2_9 hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_h_ch6.appf.tab20_1_1_2_11 hd_h_ch6.appf.tab20_1_1_1_4 hd_h_ch6.appf.tab20_1_1_1_5" id="hd_b_ch6.appf.tab20_1_1_27_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (teacher, SDQ, 0-54, high is poor, CS, >3 months PT (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_1 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_2 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_3 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab20_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_4 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_5 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_6 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab20_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab20_1_1_1_1 hd_h_ch6.appf.tab20_1_1_2_7 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_8 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_2 hd_h_ch6.appf.tab20_1_1_2_9 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_10 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab20_1_1_1_3 hd_h_ch6.appf.tab20_1_1_2_11 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.32 lower (0.57 to 0.06 lower)</td><td headers="hd_h_ch6.appf.tab20_1_1_1_4 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab20_1_1_1_5 hd_b_ch6.appf.tab20_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab20_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab20_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab21" class="table"><h3><span class="label">Table 69</span><span class="title">Clinical evidence profile: Mixed medication + NF versus mixed medication for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab21/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab21_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab21_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab21_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab21_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab21_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab21_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab21_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab21_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab21_1_1_1_1" id="hd_h_ch6.appf.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab21_1_1_1_1" id="hd_h_ch6.appf.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab21_1_1_1_1" id="hd_h_ch6.appf.tab21_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab21_1_1_1_1" id="hd_h_ch6.appf.tab21_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab21_1_1_1_1" id="hd_h_ch6.appf.tab21_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab21_1_1_1_1" id="hd_h_ch6.appf.tab21_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab21_1_1_1_1" id="hd_h_ch6.appf.tab21_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab21_1_1_1_2" id="hd_h_ch6.appf.tab21_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication + NF</th><th headers="hd_h_ch6.appf.tab21_1_1_1_2" id="hd_h_ch6.appf.tab21_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication</th><th headers="hd_h_ch6.appf.tab21_1_1_1_3" id="hd_h_ch6.appf.tab21_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab21_1_1_1_3" id="hd_h_ch6.appf.tab21_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_1 hd_h_ch6.appf.tab21_1_1_2_2 hd_h_ch6.appf.tab21_1_1_2_3 hd_h_ch6.appf.tab21_1_1_2_4 hd_h_ch6.appf.tab21_1_1_2_5 hd_h_ch6.appf.tab21_1_1_2_6 hd_h_ch6.appf.tab21_1_1_2_7 hd_h_ch6.appf.tab21_1_1_1_2 hd_h_ch6.appf.tab21_1_1_2_8 hd_h_ch6.appf.tab21_1_1_2_9 hd_h_ch6.appf.tab21_1_1_1_3 hd_h_ch6.appf.tab21_1_1_2_10 hd_h_ch6.appf.tab21_1_1_2_11 hd_h_ch6.appf.tab21_1_1_1_4 hd_h_ch6.appf.tab21_1_1_1_5" id="hd_b_ch6.appf.tab21_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_1 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_2 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_3 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab21_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_4 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_5 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_6 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab21_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_7 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab21_1_1_1_2 hd_h_ch6.appf.tab21_1_1_2_8 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">18</td><td headers="hd_h_ch6.appf.tab21_1_1_1_2 hd_h_ch6.appf.tab21_1_1_2_9 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">18</td><td headers="hd_h_ch6.appf.tab21_1_1_1_3 hd_h_ch6.appf.tab21_1_1_2_10 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab21_1_1_1_3 hd_h_ch6.appf.tab21_1_1_2_11 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.44 lower (7.07 to 1.81 lower)</td><td headers="hd_h_ch6.appf.tab21_1_1_1_4 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab21_1_1_1_5 hd_b_ch6.appf.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_1 hd_h_ch6.appf.tab21_1_1_2_2 hd_h_ch6.appf.tab21_1_1_2_3 hd_h_ch6.appf.tab21_1_1_2_4 hd_h_ch6.appf.tab21_1_1_2_5 hd_h_ch6.appf.tab21_1_1_2_6 hd_h_ch6.appf.tab21_1_1_2_7 hd_h_ch6.appf.tab21_1_1_1_2 hd_h_ch6.appf.tab21_1_1_2_8 hd_h_ch6.appf.tab21_1_1_2_9 hd_h_ch6.appf.tab21_1_1_1_3 hd_h_ch6.appf.tab21_1_1_2_10 hd_h_ch6.appf.tab21_1_1_2_11 hd_h_ch6.appf.tab21_1_1_1_4 hd_h_ch6.appf.tab21_1_1_1_5" id="hd_b_ch6.appf.tab21_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (CBRS, parent, unclear scale, high is poor, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_1 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_2 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_3 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab21_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_4 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_5 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_6 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab21_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab21_1_1_1_1 hd_h_ch6.appf.tab21_1_1_2_7 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab21_1_1_1_2 hd_h_ch6.appf.tab21_1_1_2_8 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">18</td><td headers="hd_h_ch6.appf.tab21_1_1_1_2 hd_h_ch6.appf.tab21_1_1_2_9 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">18</td><td headers="hd_h_ch6.appf.tab21_1_1_1_3 hd_h_ch6.appf.tab21_1_1_2_10 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab21_1_1_1_3 hd_h_ch6.appf.tab21_1_1_2_11 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.72 lower (6.96 to 0.48 lower)</td><td headers="hd_h_ch6.appf.tab21_1_1_1_4 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab21_1_1_1_5 hd_b_ch6.appf.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab21_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab21_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div></div><div id="ch6.appf.s1.4"><h5>COMBINATION versus NOTHING</h5><div id="ch6.appf.tab22" class="table"><h3><span class="label">Table 70</span><span class="title">Clinical evidence profile: Atomoxetine + PT/FT versus placebo/usual care for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab22/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab22_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab22_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab22_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab22_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab22_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab22_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab22_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab22_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab22_1_1_1_1" id="hd_h_ch6.appf.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab22_1_1_1_1" id="hd_h_ch6.appf.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab22_1_1_1_1" id="hd_h_ch6.appf.tab22_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab22_1_1_1_1" id="hd_h_ch6.appf.tab22_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab22_1_1_1_1" id="hd_h_ch6.appf.tab22_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab22_1_1_1_1" id="hd_h_ch6.appf.tab22_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab22_1_1_1_1" id="hd_h_ch6.appf.tab22_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab22_1_1_1_2" id="hd_h_ch6.appf.tab22_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Atomoxetine + PT/FT</th><th headers="hd_h_ch6.appf.tab22_1_1_1_2" id="hd_h_ch6.appf.tab22_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Placebo/usual care</th><th headers="hd_h_ch6.appf.tab22_1_1_1_3" id="hd_h_ch6.appf.tab22_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab22_1_1_1_3" id="hd_h_ch6.appf.tab22_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_h_ch6.appf.tab22_1_1_2_3 hd_h_ch6.appf.tab22_1_1_2_4 hd_h_ch6.appf.tab22_1_1_2_5 hd_h_ch6.appf.tab22_1_1_2_6 hd_h_ch6.appf.tab22_1_1_2_7 hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_h_ch6.appf.tab22_1_1_2_9 hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_h_ch6.appf.tab22_1_1_2_11 hd_h_ch6.appf.tab22_1_1_1_4 hd_h_ch6.appf.tab22_1_1_1_5" id="hd_b_ch6.appf.tab22_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_3 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab22_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_4 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_5 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_6 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab22_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_7 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_9 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_11 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.51 lower (0.89 to 0.13 lower)</td><td headers="hd_h_ch6.appf.tab22_1_1_1_4 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab22_1_1_1_5 hd_b_ch6.appf.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_h_ch6.appf.tab22_1_1_2_3 hd_h_ch6.appf.tab22_1_1_2_4 hd_h_ch6.appf.tab22_1_1_2_5 hd_h_ch6.appf.tab22_1_1_2_6 hd_h_ch6.appf.tab22_1_1_2_7 hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_h_ch6.appf.tab22_1_1_2_9 hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_h_ch6.appf.tab22_1_1_2_11 hd_h_ch6.appf.tab22_1_1_1_4 hd_h_ch6.appf.tab22_1_1_1_5" id="hd_b_ch6.appf.tab22_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_3 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab22_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_4 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_5 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_6 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab22_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_7 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_9 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_11 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 lower (0.71 lower to 0.11 higher)</td><td headers="hd_h_ch6.appf.tab22_1_1_1_4 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab22_1_1_1_5 hd_b_ch6.appf.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_h_ch6.appf.tab22_1_1_2_3 hd_h_ch6.appf.tab22_1_1_2_4 hd_h_ch6.appf.tab22_1_1_2_5 hd_h_ch6.appf.tab22_1_1_2_6 hd_h_ch6.appf.tab22_1_1_2_7 hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_h_ch6.appf.tab22_1_1_2_9 hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_h_ch6.appf.tab22_1_1_2_11 hd_h_ch6.appf.tab22_1_1_1_4 hd_h_ch6.appf.tab22_1_1_1_5" id="hd_b_ch6.appf.tab22_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_3 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab22_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_4 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_5 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_6 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab22_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_7 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_9 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_11 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.54 lower (0.96 to 0.12 lower)</td><td headers="hd_h_ch6.appf.tab22_1_1_1_4 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab22_1_1_1_5 hd_b_ch6.appf.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_h_ch6.appf.tab22_1_1_2_3 hd_h_ch6.appf.tab22_1_1_2_4 hd_h_ch6.appf.tab22_1_1_2_5 hd_h_ch6.appf.tab22_1_1_2_6 hd_h_ch6.appf.tab22_1_1_2_7 hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_h_ch6.appf.tab22_1_1_2_9 hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_h_ch6.appf.tab22_1_1_2_11 hd_h_ch6.appf.tab22_1_1_1_4 hd_h_ch6.appf.tab22_1_1_1_5" id="hd_b_ch6.appf.tab22_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_3 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab22_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_4 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_5 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_6 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab22_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_7 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_9 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_11 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.27 lower (0.72 lower to 0.18 higher)</td><td headers="hd_h_ch6.appf.tab22_1_1_1_4 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab22_1_1_1_5 hd_b_ch6.appf.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_h_ch6.appf.tab22_1_1_2_3 hd_h_ch6.appf.tab22_1_1_2_4 hd_h_ch6.appf.tab22_1_1_2_5 hd_h_ch6.appf.tab22_1_1_2_6 hd_h_ch6.appf.tab22_1_1_2_7 hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_h_ch6.appf.tab22_1_1_2_9 hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_h_ch6.appf.tab22_1_1_2_11 hd_h_ch6.appf.tab22_1_1_1_4 hd_h_ch6.appf.tab22_1_1_1_5" id="hd_b_ch6.appf.tab22_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_3 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab22_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_4 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_5 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_6 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab22_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_7 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_9 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_11 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.49 lower (0.87 to 0.11 lower)</td><td headers="hd_h_ch6.appf.tab22_1_1_1_4 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab22_1_1_1_5 hd_b_ch6.appf.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_h_ch6.appf.tab22_1_1_2_3 hd_h_ch6.appf.tab22_1_1_2_4 hd_h_ch6.appf.tab22_1_1_2_5 hd_h_ch6.appf.tab22_1_1_2_6 hd_h_ch6.appf.tab22_1_1_2_7 hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_h_ch6.appf.tab22_1_1_2_9 hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_h_ch6.appf.tab22_1_1_2_11 hd_h_ch6.appf.tab22_1_1_1_4 hd_h_ch6.appf.tab22_1_1_1_5" id="hd_b_ch6.appf.tab22_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months) (follow-up 10 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_3 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab22_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_4 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_5 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_6 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab22_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_7 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_9 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_11 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.33 lower (0.78 lower to 0.12 higher)</td><td headers="hd_h_ch6.appf.tab22_1_1_1_4 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab22_1_1_1_5 hd_b_ch6.appf.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_h_ch6.appf.tab22_1_1_2_3 hd_h_ch6.appf.tab22_1_1_2_4 hd_h_ch6.appf.tab22_1_1_2_5 hd_h_ch6.appf.tab22_1_1_2_6 hd_h_ch6.appf.tab22_1_1_2_7 hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_h_ch6.appf.tab22_1_1_2_9 hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_h_ch6.appf.tab22_1_1_2_11 hd_h_ch6.appf.tab22_1_1_1_4 hd_h_ch6.appf.tab22_1_1_1_5" id="hd_b_ch6.appf.tab22_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months) (follow-up 10 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_1 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_2 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_3 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab22_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_4 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_5 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_6 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab22_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab22_1_1_1_1 hd_h_ch6.appf.tab22_1_1_2_7 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_8 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>15/31</p>
|
||
<p>(48.4%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab22_1_1_1_2 hd_h_ch6.appf.tab22_1_1_2_9 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">19.4%</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_10 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 2.5 (1.12 to 5.59)</td><td headers="hd_h_ch6.appf.tab22_1_1_1_3 hd_h_ch6.appf.tab22_1_1_2_11 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">291 more per 1000 (from 23 more to 890 more)</td><td headers="hd_h_ch6.appf.tab22_1_1_1_4 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab22_1_1_1_5 hd_b_ch6.appf.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab22_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab22_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div><div id="ch6.appf.tab23" class="table"><h3><span class="label">Table 71</span><span class="title">Clinical evidence profile: Mixed medication + PT/FT versus placebo/usual care for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab23/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab23_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab23_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab23_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab23_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab23_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab23_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab23_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab23_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1" id="hd_h_ch6.appf.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab23_1_1_1_1" id="hd_h_ch6.appf.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab23_1_1_1_1" id="hd_h_ch6.appf.tab23_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab23_1_1_1_1" id="hd_h_ch6.appf.tab23_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab23_1_1_1_1" id="hd_h_ch6.appf.tab23_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab23_1_1_1_1" id="hd_h_ch6.appf.tab23_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab23_1_1_1_1" id="hd_h_ch6.appf.tab23_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab23_1_1_1_2" id="hd_h_ch6.appf.tab23_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Mixed medication + PT/FT</th><th headers="hd_h_ch6.appf.tab23_1_1_1_2" id="hd_h_ch6.appf.tab23_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Placebo/usual care</th><th headers="hd_h_ch6.appf.tab23_1_1_1_3" id="hd_h_ch6.appf.tab23_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab23_1_1_1_3" id="hd_h_ch6.appf.tab23_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">116</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.06 lower (0.2 lower to 0.08 higher)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">128</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.50 lower (0.69 to 0.31 lower)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">133</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">130</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.50 higher (0.34 to 0.66 higher)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">114</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">109</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.03 higher (0.02 lower to 0.08 higher)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">133</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">130</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.47 lower (0.63 to 0.31 lower)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months) (follow-up 14 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">134</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">128</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.36 lower (0.55 to 0.17 lower)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 7.05 higher (3.69 to 10.41 higher)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">136</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">131</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.10 higher (3.69 lower to 3.89 higher)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months) (follow-up 8 weeks; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab23_3">3</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 7.66 higher (3.35 to 11.97 higher)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">136</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">131</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.00 higher (0.47 to 7.53 higher)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_h_ch6.appf.tab23_1_1_2_3 hd_h_ch6.appf.tab23_1_1_2_4 hd_h_ch6.appf.tab23_1_1_2_5 hd_h_ch6.appf.tab23_1_1_2_6 hd_h_ch6.appf.tab23_1_1_2_7 hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_h_ch6.appf.tab23_1_1_2_9 hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_h_ch6.appf.tab23_1_1_2_11 hd_h_ch6.appf.tab23_1_1_1_4 hd_h_ch6.appf.tab23_1_1_1_5" id="hd_b_ch6.appf.tab23_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months) (follow-up 14 months; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_1 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_2 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_3 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab23_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_4 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_5 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_6 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab23_1_1_1_1 hd_h_ch6.appf.tab23_1_1_2_7 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_8 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">127</td><td headers="hd_h_ch6.appf.tab23_1_1_1_2 hd_h_ch6.appf.tab23_1_1_2_9 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">116</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_10 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab23_1_1_1_3 hd_h_ch6.appf.tab23_1_1_2_11 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.70 higher (1.87 lower to 5.27 higher)</td><td headers="hd_h_ch6.appf.tab23_1_1_1_4 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab23_1_1_1_5 hd_b_ch6.appf.tab23_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab23_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab23_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>3</dt><dd><div id="ch6.appf.tab23_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div id="ch6.appf.s1.5"><h5>COMBINATION versus OTHER COMBINATION</h5><div id="ch6.appf.tab24" class="table"><h3><span class="label">Table 72</span><span class="title">Clinical evidence profile: Stimulants + NF versus stimulants + attention/memory/cognitive training for ADHD in children and young people</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab24/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab24_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab24_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab24_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab24_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab24_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab24_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab24_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab24_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1" id="hd_h_ch6.appf.tab24_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab24_1_1_1_1" id="hd_h_ch6.appf.tab24_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab24_1_1_1_1" id="hd_h_ch6.appf.tab24_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab24_1_1_1_1" id="hd_h_ch6.appf.tab24_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab24_1_1_1_1" id="hd_h_ch6.appf.tab24_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab24_1_1_1_1" id="hd_h_ch6.appf.tab24_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab24_1_1_1_1" id="hd_h_ch6.appf.tab24_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab24_1_1_1_2" id="hd_h_ch6.appf.tab24_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + NF</th><th headers="hd_h_ch6.appf.tab24_1_1_1_2" id="hd_h_ch6.appf.tab24_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + attention/memory/cognitive training</th><th headers="hd_h_ch6.appf.tab24_1_1_1_3" id="hd_h_ch6.appf.tab24_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab24_1_1_1_3" id="hd_h_ch6.appf.tab24_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months) (follow-up 8-20 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.60 lower (6.97 lower to 1.77 higher)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months) (follow-up 8-20 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.90 lower (8.79 lower to 0.99 higher)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 7.00 lower (10.85 to 3.15 lower)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 8.70 lower (13.12 to 4.28 lower)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months) (follow-up 8-20 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.70 lower (3.42 lower to 2.02 higher)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months) (follow-up 8-20 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.60 lower (4.57 lower to 1.37 higher)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.20 lower (5.83 to 0.57 lower)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.70 lower (6.89 to 0.51 lower)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months) (follow-up 8-20 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.30 lower (3.83 lower to 1.23 higher)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months) (follow-up 8-20 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.40 lower (5.1 lower to 0.3 higher)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months) (follow-up 6 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab24_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.10 lower (6.43 to 1.77 lower)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_h_ch6.appf.tab24_1_1_2_3 hd_h_ch6.appf.tab24_1_1_2_4 hd_h_ch6.appf.tab24_1_1_2_5 hd_h_ch6.appf.tab24_1_1_2_6 hd_h_ch6.appf.tab24_1_1_2_7 hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_h_ch6.appf.tab24_1_1_2_9 hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_h_ch6.appf.tab24_1_1_2_11 hd_h_ch6.appf.tab24_1_1_1_4 hd_h_ch6.appf.tab24_1_1_1_5" id="hd_b_ch6.appf.tab24_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months) (follow-up 6 months; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_1 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_2 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_3 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_4 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_5 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_6 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab24_1_1_1_1 hd_h_ch6.appf.tab24_1_1_2_7 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_8 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31</td><td headers="hd_h_ch6.appf.tab24_1_1_1_2 hd_h_ch6.appf.tab24_1_1_2_9 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_10 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab24_1_1_1_3 hd_h_ch6.appf.tab24_1_1_2_11 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 5.50 lower (7.4 to 3.6 lower)</td><td headers="hd_h_ch6.appf.tab24_1_1_1_4 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁⨁</p>
|
||
<p>HIGH</p>
|
||
</td><td headers="hd_h_ch6.appf.tab24_1_1_1_5 hd_b_ch6.appf.tab24_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab24_1"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd></dl></div></div></div></div></div><div id="ch6.appf.s2"><h4>Adults (>18 years old)</h4><div id="ch6.appf.s2.1"><h5>DRUGS versus NON-DRUGS</h5><div id="ch6.appf.tab25" class="table"><h3><span class="label">Table 73</span><span class="title">Clinical evidence profile: Stimulants +NSST versus CBT for ADHD in adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab25/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab25_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab25_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab25_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab25_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab25_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab25_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab25_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab25_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab25_1_1_1_1" id="hd_h_ch6.appf.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab25_1_1_1_1" id="hd_h_ch6.appf.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab25_1_1_1_1" id="hd_h_ch6.appf.tab25_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab25_1_1_1_1" id="hd_h_ch6.appf.tab25_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab25_1_1_1_1" id="hd_h_ch6.appf.tab25_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab25_1_1_1_1" id="hd_h_ch6.appf.tab25_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab25_1_1_1_1" id="hd_h_ch6.appf.tab25_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab25_1_1_1_2" id="hd_h_ch6.appf.tab25_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + NSST</th><th headers="hd_h_ch6.appf.tab25_1_1_1_2" id="hd_h_ch6.appf.tab25_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Control</th><th headers="hd_h_ch6.appf.tab25_1_1_1_3" id="hd_h_ch6.appf.tab25_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab25_1_1_1_3" id="hd_h_ch6.appf.tab25_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_h_ch6.appf.tab25_1_1_2_3 hd_h_ch6.appf.tab25_1_1_2_4 hd_h_ch6.appf.tab25_1_1_2_5 hd_h_ch6.appf.tab25_1_1_2_6 hd_h_ch6.appf.tab25_1_1_2_7 hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_h_ch6.appf.tab25_1_1_2_9 hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_h_ch6.appf.tab25_1_1_2_11 hd_h_ch6.appf.tab25_1_1_1_4 hd_h_ch6.appf.tab25_1_1_1_5" id="hd_b_ch6.appf.tab25_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 1 years; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_3 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab25_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_4 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_5 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_6 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab25_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_7 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">106</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_9 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">107</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_11 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.80 lower (3.63 lower to 0.03 higher)</td><td headers="hd_h_ch6.appf.tab25_1_1_1_4 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab25_1_1_1_5 hd_b_ch6.appf.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_h_ch6.appf.tab25_1_1_2_3 hd_h_ch6.appf.tab25_1_1_2_4 hd_h_ch6.appf.tab25_1_1_2_5 hd_h_ch6.appf.tab25_1_1_2_6 hd_h_ch6.appf.tab25_1_1_2_7 hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_h_ch6.appf.tab25_1_1_2_9 hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_h_ch6.appf.tab25_1_1_2_11 hd_h_ch6.appf.tab25_1_1_1_4 hd_h_ch6.appf.tab25_1_1_1_5" id="hd_b_ch6.appf.tab25_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 1 years; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_3 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab25_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_4 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_5 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_6 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab25_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_7 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">107</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_9 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_11 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.80 lower (3.49 to 0.11 lower)</td><td headers="hd_h_ch6.appf.tab25_1_1_1_4 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab25_1_1_1_5 hd_b_ch6.appf.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_h_ch6.appf.tab25_1_1_2_3 hd_h_ch6.appf.tab25_1_1_2_4 hd_h_ch6.appf.tab25_1_1_2_5 hd_h_ch6.appf.tab25_1_1_2_6 hd_h_ch6.appf.tab25_1_1_2_7 hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_h_ch6.appf.tab25_1_1_2_9 hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_h_ch6.appf.tab25_1_1_2_11 hd_h_ch6.appf.tab25_1_1_1_4 hd_h_ch6.appf.tab25_1_1_1_5" id="hd_b_ch6.appf.tab25_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 1 years; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_3 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab25_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_4 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_5 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_6 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab25_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_7 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">107</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_9 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_11 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.60 lower (3.41 lower to 0.21 higher)</td><td headers="hd_h_ch6.appf.tab25_1_1_1_4 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab25_1_1_1_5 hd_b_ch6.appf.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_h_ch6.appf.tab25_1_1_2_3 hd_h_ch6.appf.tab25_1_1_2_4 hd_h_ch6.appf.tab25_1_1_2_5 hd_h_ch6.appf.tab25_1_1_2_6 hd_h_ch6.appf.tab25_1_1_2_7 hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_h_ch6.appf.tab25_1_1_2_9 hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_h_ch6.appf.tab25_1_1_2_11 hd_h_ch6.appf.tab25_1_1_1_4 hd_h_ch6.appf.tab25_1_1_1_5" id="hd_b_ch6.appf.tab25_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 1 years; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_3 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab25_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_4 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_5 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_6 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_7 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">106</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_9 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">107</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_11 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.80 higher (0.95 lower to 2.55 higher)</td><td headers="hd_h_ch6.appf.tab25_1_1_1_4 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab25_1_1_1_5 hd_b_ch6.appf.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_h_ch6.appf.tab25_1_1_2_3 hd_h_ch6.appf.tab25_1_1_2_4 hd_h_ch6.appf.tab25_1_1_2_5 hd_h_ch6.appf.tab25_1_1_2_6 hd_h_ch6.appf.tab25_1_1_2_7 hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_h_ch6.appf.tab25_1_1_2_9 hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_h_ch6.appf.tab25_1_1_2_11 hd_h_ch6.appf.tab25_1_1_1_4 hd_h_ch6.appf.tab25_1_1_1_5" id="hd_b_ch6.appf.tab25_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT) (follow-up 1 years; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_1 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_2 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_3 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab25_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_4 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_5 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_6 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab25_1_1_1_1 hd_h_ch6.appf.tab25_1_1_2_7 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_8 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">107</td><td headers="hd_h_ch6.appf.tab25_1_1_1_2 hd_h_ch6.appf.tab25_1_1_2_9 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_10 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab25_1_1_1_3 hd_h_ch6.appf.tab25_1_1_2_11 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 higher (1.77 lower to 2.17 higher)</td><td headers="hd_h_ch6.appf.tab25_1_1_1_4 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab25_1_1_1_5 hd_b_ch6.appf.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab25_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab25_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></div></div></div></div><div id="ch6.appf.s2.2"><h5>COMBINATION versus NON-DRUGS</h5><div id="ch6.appf.tab26" class="table"><h3><span class="label">Table 74</span><span class="title">Clinical evidence profile: Stimulants + CBT/DBT versus CBT/DBT for ADHD in adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab26/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab26_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab26_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab26_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab26_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab26_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab26_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab26_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab26_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1" id="hd_h_ch6.appf.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab26_1_1_1_1" id="hd_h_ch6.appf.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab26_1_1_1_1" id="hd_h_ch6.appf.tab26_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab26_1_1_1_1" id="hd_h_ch6.appf.tab26_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab26_1_1_1_1" id="hd_h_ch6.appf.tab26_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab26_1_1_1_1" id="hd_h_ch6.appf.tab26_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab26_1_1_1_1" id="hd_h_ch6.appf.tab26_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab26_1_1_1_2" id="hd_h_ch6.appf.tab26_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + CBT/DBT</th><th headers="hd_h_ch6.appf.tab26_1_1_1_2" id="hd_h_ch6.appf.tab26_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">CBT/DBT alone</th><th headers="hd_h_ch6.appf.tab26_1_1_1_3" id="hd_h_ch6.appf.tab26_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab26_1_1_1_3" id="hd_h_ch6.appf.tab26_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 1 years; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">106</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.60 lower (2.5 to 0.7 lower)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, multiple tools, decreased by >30%, >3 months PT) - General population (follow-up 14 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab26_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>25/53</p>
|
||
<p>(47.2%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">54.7%</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.86 (0.59 to 1.26)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">77 fewer per 1000 (from 224 fewer to 142 more)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, multiple tools, decreased by >30%, >3 months PT) - Secure estate (follow-up 24 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>17/27</p>
|
||
<p>(63%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26.9%</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 2.34 (1.17 to 4.69)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">360 more per 1000 (from 46 more to 993 more)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, TAADDS, decreased by >30%, >3 months PT) (follow-up 14 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>21/53</p>
|
||
<p>(39.6%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28.3%</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 1.4 (0.81 to 2.41)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">113 more per 1000 (from 54 fewer to 399 more)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, multiple tools, high is worse, FV, >3 months PT) (follow-up 20-52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">126</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">131</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.43 lower (0.67 to 0.18 lower)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">106</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.90 lower (2.84 to 0.96 lower)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">106</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.00 lower (1.92 to 0.08 lower)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (multiple tools, high is poor, FV, >3 months PT) (follow-up 20-52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab26_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">126</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">131</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.06 lower (0.3 lower to 0.19 higher)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (>3 months PT) (follow-up 14 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab26_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>18/53</p>
|
||
<p>(34%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30.2%</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 1.12 (0.65 to 1.96)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36 more per 1000 (from 106 fewer to 290 more)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_h_ch6.appf.tab26_1_1_2_3 hd_h_ch6.appf.tab26_1_1_2_4 hd_h_ch6.appf.tab26_1_1_2_5 hd_h_ch6.appf.tab26_1_1_2_6 hd_h_ch6.appf.tab26_1_1_2_7 hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_h_ch6.appf.tab26_1_1_2_9 hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_h_ch6.appf.tab26_1_1_2_11 hd_h_ch6.appf.tab26_1_1_1_4 hd_h_ch6.appf.tab26_1_1_1_5" id="hd_b_ch6.appf.tab26_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (>3 months FU) (follow-up 20 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_1 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_2 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_3 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_4 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_5 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_6 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab26_1_1_1_1 hd_h_ch6.appf.tab26_1_1_2_7 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_8 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>15/23</p>
|
||
<p>(65.2%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_2 hd_h_ch6.appf.tab26_1_1_2_9 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">16%</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_10 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 4.08 (1.58 to 10.5)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_3 hd_h_ch6.appf.tab26_1_1_2_11 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">493 more per 1000 (from 93 more to 1000 more)</td><td headers="hd_h_ch6.appf.tab26_1_1_1_4 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁</p>
|
||
<p>HIGH</p>
|
||
</td><td headers="hd_h_ch6.appf.tab26_1_1_1_5 hd_b_ch6.appf.tab26_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab26_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab26_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></div></div></div><div id="ch6.appf.tab27" class="table"><h3><span class="label">Table 75</span><span class="title">Clinical evidence profile: Stimulants + CBT/DBT + PT/FT versus NSST + PT/FT for ADHD in adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab27/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab27_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab27_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab27_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab27_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab27_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab27_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab27_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab27_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab27_1_1_1_1" id="hd_h_ch6.appf.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab27_1_1_1_1" id="hd_h_ch6.appf.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab27_1_1_1_1" id="hd_h_ch6.appf.tab27_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab27_1_1_1_1" id="hd_h_ch6.appf.tab27_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab27_1_1_1_1" id="hd_h_ch6.appf.tab27_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab27_1_1_1_1" id="hd_h_ch6.appf.tab27_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab27_1_1_1_1" id="hd_h_ch6.appf.tab27_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab27_1_1_1_2" id="hd_h_ch6.appf.tab27_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + CBT/DBT + PT/FT</th><th headers="hd_h_ch6.appf.tab27_1_1_1_2" id="hd_h_ch6.appf.tab27_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NSST + PT/FT</th><th headers="hd_h_ch6.appf.tab27_1_1_1_3" id="hd_h_ch6.appf.tab27_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab27_1_1_1_3" id="hd_h_ch6.appf.tab27_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_h_ch6.appf.tab27_1_1_2_3 hd_h_ch6.appf.tab27_1_1_2_4 hd_h_ch6.appf.tab27_1_1_2_5 hd_h_ch6.appf.tab27_1_1_2_6 hd_h_ch6.appf.tab27_1_1_2_7 hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_h_ch6.appf.tab27_1_1_2_9 hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_h_ch6.appf.tab27_1_1_2_11 hd_h_ch6.appf.tab27_1_1_1_4 hd_h_ch6.appf.tab27_1_1_1_5" id="hd_b_ch6.appf.tab27_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, CAARS, 0-36, high is poor, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_3 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_4 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_5 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_6 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_7 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">77</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_9 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">66</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_11 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.70 lower (4.58 to 0.82 lower)</td><td headers="hd_h_ch6.appf.tab27_1_1_1_4 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab27_1_1_1_5 hd_b_ch6.appf.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_h_ch6.appf.tab27_1_1_2_3 hd_h_ch6.appf.tab27_1_1_2_4 hd_h_ch6.appf.tab27_1_1_2_5 hd_h_ch6.appf.tab27_1_1_2_6 hd_h_ch6.appf.tab27_1_1_2_7 hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_h_ch6.appf.tab27_1_1_2_9 hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_h_ch6.appf.tab27_1_1_2_11 hd_h_ch6.appf.tab27_1_1_1_4 hd_h_ch6.appf.tab27_1_1_1_5" id="hd_b_ch6.appf.tab27_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-36, high is poor, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_3 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_4 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_5 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_6 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_7 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">77</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_9 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">66</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_11 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.00 lower (4.88 to 1.12 lower)</td><td headers="hd_h_ch6.appf.tab27_1_1_1_4 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab27_1_1_1_5 hd_b_ch6.appf.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_h_ch6.appf.tab27_1_1_2_3 hd_h_ch6.appf.tab27_1_1_2_4 hd_h_ch6.appf.tab27_1_1_2_5 hd_h_ch6.appf.tab27_1_1_2_6 hd_h_ch6.appf.tab27_1_1_2_7 hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_h_ch6.appf.tab27_1_1_2_9 hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_h_ch6.appf.tab27_1_1_2_11 hd_h_ch6.appf.tab27_1_1_1_4 hd_h_ch6.appf.tab27_1_1_1_5" id="hd_b_ch6.appf.tab27_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-36, high is poor, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_3 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_4 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_5 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_6 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_7 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">77</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_9 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">66</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_11 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.70 lower (4.79 to 0.61 lower)</td><td headers="hd_h_ch6.appf.tab27_1_1_1_4 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab27_1_1_1_5 hd_b_ch6.appf.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_h_ch6.appf.tab27_1_1_2_3 hd_h_ch6.appf.tab27_1_1_2_4 hd_h_ch6.appf.tab27_1_1_2_5 hd_h_ch6.appf.tab27_1_1_2_6 hd_h_ch6.appf.tab27_1_1_2_7 hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_h_ch6.appf.tab27_1_1_2_9 hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_h_ch6.appf.tab27_1_1_2_11 hd_h_ch6.appf.tab27_1_1_1_4 hd_h_ch6.appf.tab27_1_1_1_5" id="hd_b_ch6.appf.tab27_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Child’s ADHD symptoms (total, parent, SDQ, 0-10, high is poor, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_3 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_4 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_5 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_6 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_7 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">77</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_9 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">67</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_11 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.50 lower (1.13 lower to 0.13 higher)</td><td headers="hd_h_ch6.appf.tab27_1_1_1_4 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab27_1_1_1_5 hd_b_ch6.appf.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_h_ch6.appf.tab27_1_1_2_3 hd_h_ch6.appf.tab27_1_1_2_4 hd_h_ch6.appf.tab27_1_1_2_5 hd_h_ch6.appf.tab27_1_1_2_6 hd_h_ch6.appf.tab27_1_1_2_7 hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_h_ch6.appf.tab27_1_1_2_9 hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_h_ch6.appf.tab27_1_1_2_11 hd_h_ch6.appf.tab27_1_1_1_4 hd_h_ch6.appf.tab27_1_1_1_5" id="hd_b_ch6.appf.tab27_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (parent, SDQ, 0-10, high is poor, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_1 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_2 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_3 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab27_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_4 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_5 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_6 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab27_1_1_1_1 hd_h_ch6.appf.tab27_1_1_2_7 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_8 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">77</td><td headers="hd_h_ch6.appf.tab27_1_1_1_2 hd_h_ch6.appf.tab27_1_1_2_9 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">67</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_10 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab27_1_1_1_3 hd_h_ch6.appf.tab27_1_1_2_11 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 higher (0.43 lower to 0.83 higher)</td><td headers="hd_h_ch6.appf.tab27_1_1_1_4 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab27_1_1_1_5 hd_b_ch6.appf.tab27_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab27_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab27_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></div></div></div></div><div id="ch6.appf.s2.3"><h5>COMBINATION versus DRUGS</h5><div id="ch6.appf.tab28" class="table"><h3><span class="label">Table 76</span><span class="title">Clinical evidence profile: Stimulants + CBT/DBT versus stimulants + NSST for ADHD in adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab28/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab28_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab28_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab28_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab28_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab28_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab28_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab28_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab28_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab28_1_1_1_1" id="hd_h_ch6.appf.tab28_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab28_1_1_1_1" id="hd_h_ch6.appf.tab28_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab28_1_1_1_1" id="hd_h_ch6.appf.tab28_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab28_1_1_1_1" id="hd_h_ch6.appf.tab28_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab28_1_1_1_1" id="hd_h_ch6.appf.tab28_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab28_1_1_1_1" id="hd_h_ch6.appf.tab28_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab28_1_1_1_1" id="hd_h_ch6.appf.tab28_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab28_1_1_1_2" id="hd_h_ch6.appf.tab28_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + CBT/DBT</th><th headers="hd_h_ch6.appf.tab28_1_1_1_2" id="hd_h_ch6.appf.tab28_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + NSST</th><th headers="hd_h_ch6.appf.tab28_1_1_1_3" id="hd_h_ch6.appf.tab28_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab28_1_1_1_3" id="hd_h_ch6.appf.tab28_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_h_ch6.appf.tab28_1_1_2_3 hd_h_ch6.appf.tab28_1_1_2_4 hd_h_ch6.appf.tab28_1_1_2_5 hd_h_ch6.appf.tab28_1_1_2_6 hd_h_ch6.appf.tab28_1_1_2_7 hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_h_ch6.appf.tab28_1_1_2_9 hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_h_ch6.appf.tab28_1_1_2_11 hd_h_ch6.appf.tab28_1_1_1_4 hd_h_ch6.appf.tab28_1_1_1_5" id="hd_b_ch6.appf.tab28_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_3 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab28_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_4 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_5 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_6 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_7 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_9 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">110</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_11 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 higher (1.55 lower to 1.95 higher)</td><td headers="hd_h_ch6.appf.tab28_1_1_1_4 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab28_1_1_1_5 hd_b_ch6.appf.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_h_ch6.appf.tab28_1_1_2_3 hd_h_ch6.appf.tab28_1_1_2_4 hd_h_ch6.appf.tab28_1_1_2_5 hd_h_ch6.appf.tab28_1_1_2_6 hd_h_ch6.appf.tab28_1_1_2_7 hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_h_ch6.appf.tab28_1_1_2_9 hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_h_ch6.appf.tab28_1_1_2_11 hd_h_ch6.appf.tab28_1_1_1_4 hd_h_ch6.appf.tab28_1_1_1_5" id="hd_b_ch6.appf.tab28_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_3 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab28_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_4 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_5 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_6 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_7 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_9 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">110</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_11 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 higher (1.45 lower to 2.05 higher)</td><td headers="hd_h_ch6.appf.tab28_1_1_1_4 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab28_1_1_1_5 hd_b_ch6.appf.tab28_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_h_ch6.appf.tab28_1_1_2_3 hd_h_ch6.appf.tab28_1_1_2_4 hd_h_ch6.appf.tab28_1_1_2_5 hd_h_ch6.appf.tab28_1_1_2_6 hd_h_ch6.appf.tab28_1_1_2_7 hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_h_ch6.appf.tab28_1_1_2_9 hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_h_ch6.appf.tab28_1_1_2_11 hd_h_ch6.appf.tab28_1_1_1_4 hd_h_ch6.appf.tab28_1_1_1_5" id="hd_b_ch6.appf.tab28_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_3 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab28_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_4 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_5 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_6 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_7 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_9 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">106</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_11 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.30 lower (1.98 lower to 1.38 higher)</td><td headers="hd_h_ch6.appf.tab28_1_1_1_4 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab28_1_1_1_5 hd_b_ch6.appf.tab28_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_h_ch6.appf.tab28_1_1_2_3 hd_h_ch6.appf.tab28_1_1_2_4 hd_h_ch6.appf.tab28_1_1_2_5 hd_h_ch6.appf.tab28_1_1_2_6 hd_h_ch6.appf.tab28_1_1_2_7 hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_h_ch6.appf.tab28_1_1_2_9 hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_h_ch6.appf.tab28_1_1_2_11 hd_h_ch6.appf.tab28_1_1_1_4 hd_h_ch6.appf.tab28_1_1_1_5" id="hd_b_ch6.appf.tab28_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_3 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab28_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_4 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_5 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_6 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_7 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_9 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">106</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_11 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.20 lower (1.88 lower to 1.48 higher)</td><td headers="hd_h_ch6.appf.tab28_1_1_1_4 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab28_1_1_1_5 hd_b_ch6.appf.tab28_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_h_ch6.appf.tab28_1_1_2_3 hd_h_ch6.appf.tab28_1_1_2_4 hd_h_ch6.appf.tab28_1_1_2_5 hd_h_ch6.appf.tab28_1_1_2_6 hd_h_ch6.appf.tab28_1_1_2_7 hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_h_ch6.appf.tab28_1_1_2_9 hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_h_ch6.appf.tab28_1_1_2_11 hd_h_ch6.appf.tab28_1_1_1_4 hd_h_ch6.appf.tab28_1_1_1_5" id="hd_b_ch6.appf.tab28_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_1 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_2 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_3 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab28_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_4 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_5 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_6 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab28_1_1_1_1 hd_h_ch6.appf.tab28_1_1_2_7 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_8 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab28_1_1_1_2 hd_h_ch6.appf.tab28_1_1_2_9 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">110</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_10 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab28_1_1_1_3 hd_h_ch6.appf.tab28_1_1_2_11 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.70 lower (2.66 lower to 1.26 higher)</td><td headers="hd_h_ch6.appf.tab28_1_1_1_4 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab28_1_1_1_5 hd_b_ch6.appf.tab28_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab28_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd></dl></div></div></div><div id="ch6.appf.tab29" class="table"><h3><span class="label">Table 77</span><span class="title">Clinical evidence profile: Medication + CBT/DBT versus medication for ADHD in adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab29/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab29_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab29_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab29_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab29_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab29_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab29_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab29_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab29_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1" id="hd_h_ch6.appf.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab29_1_1_1_1" id="hd_h_ch6.appf.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab29_1_1_1_1" id="hd_h_ch6.appf.tab29_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab29_1_1_1_1" id="hd_h_ch6.appf.tab29_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab29_1_1_1_1" id="hd_h_ch6.appf.tab29_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab29_1_1_1_1" id="hd_h_ch6.appf.tab29_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab29_1_1_1_1" id="hd_h_ch6.appf.tab29_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab29_1_1_1_2" id="hd_h_ch6.appf.tab29_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Medication + CBT/DBT</th><th headers="hd_h_ch6.appf.tab29_1_1_1_2" id="hd_h_ch6.appf.tab29_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Medication alone</th><th headers="hd_h_ch6.appf.tab29_1_1_1_3" id="hd_h_ch6.appf.tab29_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab29_1_1_1_3" id="hd_h_ch6.appf.tab29_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">QoL (Flanagan, 16-112, high is good, FV, <3 months PT) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.60 higher (3.68 lower to 10.88 higher)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">QoL (Flanagan, 16-112, high is good, FV, <3 months FU) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 7.62 higher (1.03 to 14.21 higher)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, ADHD-RS, 0-54, higher is worse, FV, PT >3 months) (follow-up 15 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">16</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 5.61 lower (12.11 lower to 0.89 higher)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, 0-54, higher is worse, FV, PT >3 months) (follow-up 15 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">16</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 9.12 lower (15.69 to 2.55 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, Barkley, 0-54, high is poor, FV, <3 months PT) (follow-up 8-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5.01 lower (8.30 to 1.72 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, Barkley, 0-54, high is poor, FV, <3 months FU) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">8.23 lower (11.86 lower to 4.61 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, Barkley, 0-27, high is poor, FV, <3 months PT) (follow-up 8-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1.36 lower (3.46 lower to 0.74 higher)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, Barkley, 0-27, high is poor, FV, <3 months FU) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2.97 lower (4.90 to 1.03 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, Barkley, 0-27, high is poor, FV, <3 months PT) (follow-up 8-12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3.63 lower (5.55 to 1.71 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, Barkley, 0-27, high is poor, FV, <3 months FU) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">49</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5.26 lower (7.60 to 2.93 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Responders by CGI (two point change in CGI-S, >3 months PT) (follow-up 15 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>9/16</p>
|
||
<p>(56.3%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">13.3%</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 4.22 (1.08 to 16.45)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">428 more per 1000 (from 11 more to 1000 more)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_21_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (observer, HAM-D, 0-53, high is worse, FV, >3 months PT) (follow-up 15 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">16</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 5.56 lower (9.71 to 1.41 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_23_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_25_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-64, high is worse, FV, <3 months PT) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 5.62 lower (9.85 to 1.39 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_25_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_27_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-64, high is worse, FV, <3 months FU) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 8.10 lower (11.72 to 4.43 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_27_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_29_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (Self-rated, RATE antisocial scale, unclear range, high is worse, FV, <3 months PT) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.05 lower (1.99 to 0.11 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_29_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_h_ch6.appf.tab29_1_1_2_3 hd_h_ch6.appf.tab29_1_1_2_4 hd_h_ch6.appf.tab29_1_1_2_5 hd_h_ch6.appf.tab29_1_1_2_6 hd_h_ch6.appf.tab29_1_1_2_7 hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_h_ch6.appf.tab29_1_1_2_9 hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_h_ch6.appf.tab29_1_1_2_11 hd_h_ch6.appf.tab29_1_1_1_4 hd_h_ch6.appf.tab29_1_1_1_5" id="hd_b_ch6.appf.tab29_1_1_31_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (Self-rated, RATE antisocial scale, unclear range, high is worse, FV, <3 months FU) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_1 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_2 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_3 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab29_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_4 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_5 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_6 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab29_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab29_1_1_1_1 hd_h_ch6.appf.tab29_1_1_2_7 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_8 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25</td><td headers="hd_h_ch6.appf.tab29_1_1_1_2 hd_h_ch6.appf.tab29_1_1_2_9 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_10 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab29_1_1_1_3 hd_h_ch6.appf.tab29_1_1_2_11 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.43 lower (3.97 to 0.89 lower)</td><td headers="hd_h_ch6.appf.tab29_1_1_1_4 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab29_1_1_1_5 hd_b_ch6.appf.tab29_1_1_31_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab29_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab29_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></div></div></div><div id="ch6.appf.tab30" class="table"><h3><span class="label">Table 78</span><span class="title">Clinical evidence profile: Medication + CBT/DBT versus Medication + NSST for ADHD in adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab30/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab30_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab30_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab30_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab30_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab30_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab30_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab30_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab30_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab30_1_1_1_1" id="hd_h_ch6.appf.tab30_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab30_1_1_1_1" id="hd_h_ch6.appf.tab30_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab30_1_1_1_1" id="hd_h_ch6.appf.tab30_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab30_1_1_1_1" id="hd_h_ch6.appf.tab30_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab30_1_1_1_1" id="hd_h_ch6.appf.tab30_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab30_1_1_1_1" id="hd_h_ch6.appf.tab30_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab30_1_1_1_1" id="hd_h_ch6.appf.tab30_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab30_1_1_1_2" id="hd_h_ch6.appf.tab30_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Medication + CBT/DBT</th><th headers="hd_h_ch6.appf.tab30_1_1_1_2" id="hd_h_ch6.appf.tab30_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Medication + NSST</th><th headers="hd_h_ch6.appf.tab30_1_1_1_3" id="hd_h_ch6.appf.tab30_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab30_1_1_1_3" id="hd_h_ch6.appf.tab30_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_h_ch6.appf.tab30_1_1_2_3 hd_h_ch6.appf.tab30_1_1_2_4 hd_h_ch6.appf.tab30_1_1_2_5 hd_h_ch6.appf.tab30_1_1_2_6 hd_h_ch6.appf.tab30_1_1_2_7 hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_h_ch6.appf.tab30_1_1_2_9 hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_h_ch6.appf.tab30_1_1_2_11 hd_h_ch6.appf.tab30_1_1_1_4 hd_h_ch6.appf.tab30_1_1_1_5" id="hd_b_ch6.appf.tab30_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">QoL (QLESQ, unclear scale, high is better, FV, >3 months PT) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_3 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab30_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_4 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_5 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_6 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab30_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_7 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_9 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">17</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_11 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 33.10 higher (35.83 lower to 102.03 higher)</td><td headers="hd_h_ch6.appf.tab30_1_1_1_4 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab30_1_1_1_5 hd_b_ch6.appf.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_h_ch6.appf.tab30_1_1_2_3 hd_h_ch6.appf.tab30_1_1_2_4 hd_h_ch6.appf.tab30_1_1_2_5 hd_h_ch6.appf.tab30_1_1_2_6 hd_h_ch6.appf.tab30_1_1_2_7 hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_h_ch6.appf.tab30_1_1_2_9 hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_h_ch6.appf.tab30_1_1_2_11 hd_h_ch6.appf.tab30_1_1_1_4 hd_h_ch6.appf.tab30_1_1_1_5" id="hd_b_ch6.appf.tab30_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, high is worse, FV, 0-54, >3 months PT) (follow-up 12-15 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_3 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab30_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_4 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_5 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_6 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab30_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_7 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">56</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_9 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">54</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_11 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">SMD 0.33 lower (0.7 lower to 0.05 higher)</td><td headers="hd_h_ch6.appf.tab30_1_1_1_4 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab30_1_1_1_5 hd_b_ch6.appf.tab30_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_h_ch6.appf.tab30_1_1_2_3 hd_h_ch6.appf.tab30_1_1_2_4 hd_h_ch6.appf.tab30_1_1_2_5 hd_h_ch6.appf.tab30_1_1_2_6 hd_h_ch6.appf.tab30_1_1_2_7 hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_h_ch6.appf.tab30_1_1_2_9 hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_h_ch6.appf.tab30_1_1_2_11 hd_h_ch6.appf.tab30_1_1_1_4 hd_h_ch6.appf.tab30_1_1_1_5" id="hd_b_ch6.appf.tab30_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, high is worse, FV, 0-54, >3 months FU) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_3 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab30_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_4 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_5 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_6 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab30_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_7 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">38</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_9 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_11 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.58 lower (6.34 to 0.82 lower)</td><td headers="hd_h_ch6.appf.tab30_1_1_1_4 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab30_1_1_1_5 hd_b_ch6.appf.tab30_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_h_ch6.appf.tab30_1_1_2_3 hd_h_ch6.appf.tab30_1_1_2_4 hd_h_ch6.appf.tab30_1_1_2_5 hd_h_ch6.appf.tab30_1_1_2_6 hd_h_ch6.appf.tab30_1_1_2_7 hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_h_ch6.appf.tab30_1_1_2_9 hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_h_ch6.appf.tab30_1_1_2_11 hd_h_ch6.appf.tab30_1_1_1_4 hd_h_ch6.appf.tab30_1_1_1_5" id="hd_b_ch6.appf.tab30_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, CAARS, high is worse, FV, 0-27, >3 months PT) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_3 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab30_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_4 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_5 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_6 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab30_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_7 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_9 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">17</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_11 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.72 higher (4.41 lower to 7.85 higher)</td><td headers="hd_h_ch6.appf.tab30_1_1_1_4 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab30_1_1_1_5 hd_b_ch6.appf.tab30_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_h_ch6.appf.tab30_1_1_2_3 hd_h_ch6.appf.tab30_1_1_2_4 hd_h_ch6.appf.tab30_1_1_2_5 hd_h_ch6.appf.tab30_1_1_2_6 hd_h_ch6.appf.tab30_1_1_2_7 hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_h_ch6.appf.tab30_1_1_2_9 hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_h_ch6.appf.tab30_1_1_2_11 hd_h_ch6.appf.tab30_1_1_1_4 hd_h_ch6.appf.tab30_1_1_1_5" id="hd_b_ch6.appf.tab30_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, CAARS, high is worse, FV, 0-27, >3 months PT) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_3 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab30_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_4 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_5 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_6 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab30_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_7 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_9 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">17</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_11 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.35 higher (4.62 lower to 7.32 higher)</td><td headers="hd_h_ch6.appf.tab30_1_1_1_4 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab30_1_1_1_5 hd_b_ch6.appf.tab30_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_h_ch6.appf.tab30_1_1_2_3 hd_h_ch6.appf.tab30_1_1_2_4 hd_h_ch6.appf.tab30_1_1_2_5 hd_h_ch6.appf.tab30_1_1_2_6 hd_h_ch6.appf.tab30_1_1_2_7 hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_h_ch6.appf.tab30_1_1_2_9 hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_h_ch6.appf.tab30_1_1_2_11 hd_h_ch6.appf.tab30_1_1_1_4 hd_h_ch6.appf.tab30_1_1_1_5" id="hd_b_ch6.appf.tab30_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">CGI-I responders (>3 months PT) (follow-up 15 weeks)</th></tr><tr><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_3 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab30_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_4 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_5 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_6 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab30_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_7 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>22/41</p>
|
||
<p>(53.7%)</p>
|
||
</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_9 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24.3%</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 2.21 (1.17 to 4.16)</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_11 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">294 more per 1000 (from 41 more to 768 more)</td><td headers="hd_h_ch6.appf.tab30_1_1_1_4 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab30_1_1_1_5 hd_b_ch6.appf.tab30_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_h_ch6.appf.tab30_1_1_2_3 hd_h_ch6.appf.tab30_1_1_2_4 hd_h_ch6.appf.tab30_1_1_2_5 hd_h_ch6.appf.tab30_1_1_2_6 hd_h_ch6.appf.tab30_1_1_2_7 hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_h_ch6.appf.tab30_1_1_2_9 hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_h_ch6.appf.tab30_1_1_2_11 hd_h_ch6.appf.tab30_1_1_1_4 hd_h_ch6.appf.tab30_1_1_1_5" id="hd_b_ch6.appf.tab30_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-63, high is worse, FV, >3 months PT) (follow-up 12 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_1 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_2 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_3 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab30_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_4 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_5 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_6 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup><a class="bk_pop" href="#ch6.appf.tab30_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab30_1_1_1_1 hd_h_ch6.appf.tab30_1_1_2_7 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_8 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15</td><td headers="hd_h_ch6.appf.tab30_1_1_1_2 hd_h_ch6.appf.tab30_1_1_2_9 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">17</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_10 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab30_1_1_1_3 hd_h_ch6.appf.tab30_1_1_2_11 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.24 lower (9.37 lower to 6.89 higher)</td><td headers="hd_h_ch6.appf.tab30_1_1_1_4 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁◯◯◯</p>
|
||
<p>VERY LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab30_1_1_1_5 hd_b_ch6.appf.tab30_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab30_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab30_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></div></div></div></div><div id="ch6.appf.s2.4"><h5>COMBINATION versus NOTHING/USUAL CARE</h5><div id="ch6.appf.tab31" class="table"><h3><span class="label">Table 79</span><span class="title">Clinical evidence profile: Stimulants + CBT/DBT versus NSST for ADHD in adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appf.tab31/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appf.tab31_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.appf.tab31_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch6.appf.tab31_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch6.appf.tab31_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch6.appf.tab31_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab31_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch6.appf.tab31_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch6.appf.tab31_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch6.appf.tab31_1_1_1_1" id="hd_h_ch6.appf.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch6.appf.tab31_1_1_1_1" id="hd_h_ch6.appf.tab31_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch6.appf.tab31_1_1_1_1" id="hd_h_ch6.appf.tab31_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch6.appf.tab31_1_1_1_1" id="hd_h_ch6.appf.tab31_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch6.appf.tab31_1_1_1_1" id="hd_h_ch6.appf.tab31_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch6.appf.tab31_1_1_1_1" id="hd_h_ch6.appf.tab31_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch6.appf.tab31_1_1_1_1" id="hd_h_ch6.appf.tab31_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch6.appf.tab31_1_1_1_2" id="hd_h_ch6.appf.tab31_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Stimulants + CBT/DBT</th><th headers="hd_h_ch6.appf.tab31_1_1_1_2" id="hd_h_ch6.appf.tab31_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NSST alone</th><th headers="hd_h_ch6.appf.tab31_1_1_1_3" id="hd_h_ch6.appf.tab31_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch6.appf.tab31_1_1_1_3" id="hd_h_ch6.appf.tab31_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_h_ch6.appf.tab31_1_1_2_3 hd_h_ch6.appf.tab31_1_1_2_4 hd_h_ch6.appf.tab31_1_1_2_5 hd_h_ch6.appf.tab31_1_1_2_6 hd_h_ch6.appf.tab31_1_1_2_7 hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_h_ch6.appf.tab31_1_1_2_9 hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_h_ch6.appf.tab31_1_1_2_11 hd_h_ch6.appf.tab31_1_1_1_4 hd_h_ch6.appf.tab31_1_1_1_5" id="hd_b_ch6.appf.tab31_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_3 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_4 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_5 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_6 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_7 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_9 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_11 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.70 lower (4.45 to 0.95 lower)</td><td headers="hd_h_ch6.appf.tab31_1_1_1_4 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab31_1_1_1_5 hd_b_ch6.appf.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_h_ch6.appf.tab31_1_1_2_3 hd_h_ch6.appf.tab31_1_1_2_4 hd_h_ch6.appf.tab31_1_1_2_5 hd_h_ch6.appf.tab31_1_1_2_6 hd_h_ch6.appf.tab31_1_1_2_7 hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_h_ch6.appf.tab31_1_1_2_9 hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_h_ch6.appf.tab31_1_1_2_11 hd_h_ch6.appf.tab31_1_1_1_4 hd_h_ch6.appf.tab31_1_1_1_5" id="hd_b_ch6.appf.tab31_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_3 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_4 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_5 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_6 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_7 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_9 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_11 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.60 lower (4.49 to 0.71 lower)</td><td headers="hd_h_ch6.appf.tab31_1_1_1_4 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab31_1_1_1_5 hd_b_ch6.appf.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_h_ch6.appf.tab31_1_1_2_3 hd_h_ch6.appf.tab31_1_1_2_4 hd_h_ch6.appf.tab31_1_1_2_5 hd_h_ch6.appf.tab31_1_1_2_6 hd_h_ch6.appf.tab31_1_1_2_7 hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_h_ch6.appf.tab31_1_1_2_9 hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_h_ch6.appf.tab31_1_1_2_11 hd_h_ch6.appf.tab31_1_1_1_4 hd_h_ch6.appf.tab31_1_1_1_5" id="hd_b_ch6.appf.tab31_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_3 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_4 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_5 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_6 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_7 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_9 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_11 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.20 lower (4.02 to 0.38 lower)</td><td headers="hd_h_ch6.appf.tab31_1_1_1_4 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab31_1_1_1_5 hd_b_ch6.appf.tab31_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_h_ch6.appf.tab31_1_1_2_3 hd_h_ch6.appf.tab31_1_1_2_4 hd_h_ch6.appf.tab31_1_1_2_5 hd_h_ch6.appf.tab31_1_1_2_6 hd_h_ch6.appf.tab31_1_1_2_7 hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_h_ch6.appf.tab31_1_1_2_9 hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_h_ch6.appf.tab31_1_1_2_11 hd_h_ch6.appf.tab31_1_1_1_4 hd_h_ch6.appf.tab31_1_1_1_5" id="hd_b_ch6.appf.tab31_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_3 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_4 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_5 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_6 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_2">2</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_7 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_9 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_11 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.50 lower (4.32 to 0.68 lower)</td><td headers="hd_h_ch6.appf.tab31_1_1_1_4 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁◯◯</p>
|
||
<p>LOW</p>
|
||
</td><td headers="hd_h_ch6.appf.tab31_1_1_1_5 hd_b_ch6.appf.tab31_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_h_ch6.appf.tab31_1_1_2_3 hd_h_ch6.appf.tab31_1_1_2_4 hd_h_ch6.appf.tab31_1_1_2_5 hd_h_ch6.appf.tab31_1_1_2_6 hd_h_ch6.appf.tab31_1_1_2_7 hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_h_ch6.appf.tab31_1_1_2_9 hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_h_ch6.appf.tab31_1_1_2_11 hd_h_ch6.appf.tab31_1_1_1_4 hd_h_ch6.appf.tab31_1_1_1_5" id="hd_b_ch6.appf.tab31_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT) (follow-up 52 weeks; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_1 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_2 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_3 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup><a class="bk_pop" href="#ch6.appf.tab31_1">1</a></sup></td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_4 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_5 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_6 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch6.appf.tab31_1_1_1_1 hd_h_ch6.appf.tab31_1_1_2_7 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_8 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_2 hd_h_ch6.appf.tab31_1_1_2_9 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">103</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_10 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch6.appf.tab31_1_1_1_3 hd_h_ch6.appf.tab31_1_1_2_11 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 1.20 lower (3.3 lower to 0.9 higher)</td><td headers="hd_h_ch6.appf.tab31_1_1_1_4 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
||
<p>⨁⨁⨁◯</p>
|
||
<p>MODERATE</p>
|
||
</td><td headers="hd_h_ch6.appf.tab31_1_1_1_5 hd_b_ch6.appf.tab31_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.appf.tab31_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd><dt>2</dt><dd><div id="ch6.appf.tab31_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></div></div></div></div></div></div><div id="ch6.appg"><h3>Appendix G. Health economic evidence selection</h3><div id="ch6.appg.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch6appgf1&p=BOOKS&id=578099_ch6appgf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK578099/bin/ch6appgf1.jpg" alt="Image ch6appgf1" class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>* Non-relevant population, intervention, comparison, design or setting; non-English language</p><p>(a) note that there were 2 original models from the previous guideline (either included or excluded) which is why the numbers add to more than 15.</p><p>(b) Two articles identified were applicable to Q5 and Q10, for the purposes of this diagram it has been included under Q5 only.</p><p>(c) One of these is a model from the previous guideline that was exclude. Two articles identified were applicable to both Q5 and Q11 and have only been included here under Q11. One paper here was selectively excluded in Q11 but included in Q5 and so is double counted in this flowchart.</p></div></div></div><div id="ch6.apph"><h3>Appendix H. Health economic evidence tables</h3><p>None.</p></div><div id="ch6.appi"><h3>Appendix I. Excluded studies</h3><div id="ch6.appi.s1"><h4>I.1. Excluded clinical studies</h4><div id="ch6.appi.tab1" class="table"><h3><span class="label">Table 80</span><span class="title">Studies excluded from the clinical review</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appi.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appi.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study</th><th id="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusion reason</th></tr></thead><tbody><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Abbasi 2011<a class="bk_pop" href="#ch6.r2"><sup>2</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect intervention</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Aman 2009<a class="bk_pop" href="#ch6.r5"><sup>5</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect stratum</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Aman 2014<a class="bk_pop" href="#ch6.r4"><sup>4</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population. Sequencing</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Arnold 2015<a class="bk_pop" href="#ch6.r6"><sup>6</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population. Sequencing</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Babinski 2014<a class="bk_pop" href="#ch6.r7"><sup>7</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study design</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Babinski 2014<a class="bk_pop" href="#ch6.r8"><sup>8</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study design</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fabiano 2007<a class="bk_pop" href="#ch6.r14"><sup>14</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect duration</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Farmer 2012<a class="bk_pop" href="#ch6.r15"><sup>15</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No usable outcomes</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Farmer 2015<a class="bk_pop" href="#ch6.r16"><sup>16</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population. Sequencing</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Foster 2007<a class="bk_pop" href="#ch6.r18"><sup>18</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect stratum. Unusable outcomes</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gallucci 2006<a class="bk_pop" href="#ch6.r19"><sup>19</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study design</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Helseth 2015<a class="bk_pop" href="#ch6.r22"><sup>22</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No useable outcomes</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Heriot 2008<a class="bk_pop" href="#ch6.r23"><sup>23</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study design</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Janssen 2016<a class="bk_pop" href="#ch6.r27"><sup>27</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No relevant outcomes</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kang 2011<a class="bk_pop" href="#ch6.r30"><sup>30</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No usable outcomes</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Konstenius 2010<a class="bk_pop" href="#ch6.r33"><sup>33</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect intervention</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meisel 2013<a class="bk_pop" href="#ch6.r40"><sup>40</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect intervention</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mesler 2016<a class="bk_pop" href="#ch6.r42"><sup>42</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect stratum. Incorrect interventions</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Pelham 2014<a class="bk_pop" href="#ch6.r47"><sup>47</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect duration</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Pelham 2016<a class="bk_pop" href="#ch6.r48"><sup>48</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">R.g. klein 1997<a class="bk_pop" href="#ch6.r32"><sup>32</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate diagnosis</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schachar 1997<a class="bk_pop" href="#ch6.r53"><sup>53</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect intervention</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tamm 2012<a class="bk_pop" href="#ch6.r60"><sup>60</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No usable outcomes</td></tr><tr><td headers="hd_h_ch6.appi.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Warden 2012<a class="bk_pop" href="#ch6.r64"><sup>64</sup></a></td><td headers="hd_h_ch6.appi.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No usable outcomes</td></tr></tbody></table></div></div></div><div id="ch6.appi.s2"><h4>I.2. Excluded health economic studies</h4><div id="ch6.appi.tab2" class="table"><h3><span class="label">Table 81</span><span class="title">Studies excluded from the health economic review</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appi.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appi.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.appi.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reference</th><th id="hd_h_ch6.appi.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reason for exclusion</th></tr></thead><tbody><tr><td headers="hd_h_ch6.appi.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lord & Paisley 2000<a class="bk_pop" href="#ch6.r39"><sup>39</sup></a></td><td headers="hd_h_ch6.appi.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This study was assessed as not applicable, because the cost year (2000) is prior to a 15 year cut-off that the guideline employs for economic evaluations. It is also not using QALYs (cost per SMD in the SNAP-IV score)</td></tr><tr><td headers="hd_h_ch6.appi.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Zupancic 1998<a class="bk_pop" href="#ch6.r69"><sup>69</sup></a></td><td headers="hd_h_ch6.appi.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This study was assessed as not applicable because of the perspective (Canadian third party payer). The cost year was also before the guideline date cut-off (1997). The outcome is also not QALYs (Change in Conners’ teacher rating scale)</td></tr><tr><td headers="hd_h_ch6.appi.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The MTA Co-operative study Jensen et al., 2005 Foster et al., 2007<a class="bk_pop" href="#ch6.r29"><sup>29</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r18"><sup>18</sup></a></td><td headers="hd_h_ch6.appi.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This study was assessed as not applicable because it is a US study and there may be more applicable evidence. The date of costs is also before the guideline date cut-off (2001). The outcomes are also not in QALYs (cost per ‘normalised’ child, and cost per change on CIS-ES).</td></tr><tr><td headers="hd_h_ch6.appi.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">King 2006<a class="bk_pop" href="#ch6.r31"><sup>31</sup></a></td><td headers="hd_h_ch6.appi.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This study was assessed as not applicable because of methodological limitations as the RCT that clinical effectiveness of combination therapy was based on a study that has been excluded from the guideline clinical review.</td></tr><tr><td headers="hd_h_ch6.appi.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CG72 model<a class="bk_pop" href="#ch6.r45"><sup>45</sup></a></td><td headers="hd_h_ch6.appi.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The previous guideline model on children comparing combination treatments has been selectively excluded because it is not applicable as it is based on clinical evidence that is excluded from the clinical review.</td></tr></tbody></table></div></div></div></div><div id="ch6.appj"><h3>Appendix J. Research recommendations</h3><div id="ch6.appj.s1"><h4>J.1. Combination in children under 5</h4><p>
|
||
<b>Research question: What is the clinical and cost effectiveness of pharmacological vs non-pharmacological treatment versus a combination in children under 5 with ADHD?</b>
|
||
</p><p>
|
||
<b>Why this is important:</b>
|
||
</p><p>Many children are diagnosed with ADHD under the age of 5 years. There is much hesitancy around the use of ADHD medication in this age group, although there has been little research into the option. There is more evidence in this age group supporting the efficacy of non-pharmacological interventions (for example parent- training programmes), but there is no evidence directly comparing the efficacy of this with pharmacological treatment or a combination of the two.</p><div id="ch6.appj.tab1" class="table"><h3><span class="title">Criteria for selecting high-priority research recommendations</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appj.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appj.tab1_lrgtbl__"><table><tbody><tr><th id="hd_b_ch6.appj.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO question</th><td headers="hd_b_ch6.appj.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Population: Children under the age of 5 with ADHD and their parents or carers</p>
|
||
<p>Intervention(s): Pharmacological treatment (e.g. methylphenidate, lisdexamfetamine, atomoxetine or guanfacine), non-pharmacological treatment (e.g. parent-training programmes), combination</p>
|
||
<p>Comparison: Each other (3 arm study)</p>
|
||
<p>Outcome(s): Quality of life, ADHD symptoms (total, inattention, hyperactivity) assessed by neutral observer and reported as continuous and dichotomous responder outcomes, medication use, behavioural measures, discontinuations, serious adverse events</p>
|
||
</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Importance to patients or the population</th><td headers="hd_b_ch6.appj.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Either support or reject the concept of medication use in this age group</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relevance to NICE guidance</th><td headers="hd_b_ch6.appj.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Allow for evidence based recommendations on the use of medication or a combination of medication and parent-training programmes in this age group</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relevance to the NHS</th><td headers="hd_b_ch6.appj.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Provide framework for guidance around prescribing in this age group</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">National priorities</th><td headers="hd_b_ch6.appj.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE ADHD guideline</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch6.appj.tab1_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>There are a small number of studies comparing medication with placebo in this age group, a larger evidence based comparing parent-training programmes with usual care in this age group and no studies comparing the two head to head or in combination</p>
|
||
<p>There is a lack of evidence measuring the long term effects of treatments for ADHD. As a chronic lifelong condition it is imperative trials have longer follow up measuring the benefits and risks of treatments.</p>
|
||
</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Equality</th><td headers="hd_b_ch6.appj.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Research could allow for recommendations tailored to age and not based on consensus and extrapolation from older children</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch6.appj.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Feasibility</th><td headers="hd_b_ch6.appj.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ethics of randomising children in this age group to medication or not are challenging but without RCTs in this population, difficult to recommend an appropriate strategy</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch6.appj.tab1_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td></tr><tr><th id="hd_b_ch6.appj.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Importance</th><td headers="hd_b_ch6.appj.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<ul id="ch6.l56"><li id="ch6.lt192" class="half_rhythm"><div>High: the research is essential to inform future updates of key recommendations in the guideline.</div></li></ul></td></tr></tbody></table></div></div></div><div id="ch6.appj.s2"><h4>J.2. Combination in over 5s</h4><p>
|
||
<b>Research question: What is the clinical and cost effectiveness of pharmacological vs non-pharmacological treatment versus a combination in children, young people and adults over 5 with ADHD?</b>
|
||
</p><p>
|
||
<b>Why this is important:</b>
|
||
</p><p>The question of the direct head to head comparisons between pharmacological and non-pharmacological treatment or a combination of the two in children, young people and adults over 5 with ADHD is critical to treatment decisions. There are many small studies looking at a variety of specific interventions under this heading but a paucity of large, well conducted RCTs of the kind that would be required for stronger recommendations and more useful information for patients.</p><div id="ch6.appj.tab2" class="table"><h3><span class="title">Criteria for selecting high-priority research recommendations</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.appj.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.appj.tab2_lrgtbl__"><table><tbody><tr><th id="hd_b_ch6.appj.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO question</th><td headers="hd_b_ch6.appj.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Population: Children, young people and adults over the age of 5 with ADHD and their parents or carers (if applicable), ideally treatment naïve but if not, to aid recruitment, then results should be stratified by previous treatment and response</p>
|
||
<p>Intervention(s): Pharmacological treatment (e.g. methylphenidate, lisdexamfetamine, atomoxetine or guanfacine), non-pharmacological treatment (e.g. parent-training programmes in children, CBT in young people and adults), combination</p>
|
||
<p>Comparison: Each other (3 arm study)</p>
|
||
<p>Outcome(s): Quality of life, ADHD symptoms (total, inattention, hyperactivity) assessed by neutral observer and reported as continuous and dichotomous responder outcomes, medication use, behavioural measures, discontinuations, serious adverse events</p>
|
||
</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Importance to patients or the population</th><td headers="hd_b_ch6.appj.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Would provide better information on relative efficacy of these treatments to allow people to make more informed choices between options</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relevance to NICE guidance</th><td headers="hd_b_ch6.appj.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Allow for stronger evidence based recommendations on the use of medication or a combination of medication and non-pharmacological treatments</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relevance to the NHS</th><td headers="hd_b_ch6.appj.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Provide framework for guidance around prescribing in this age group</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">National priorities</th><td headers="hd_b_ch6.appj.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE ADHD guideline</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch6.appj.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>There are a large number of small studies comparing these interventions however there is a wide range of baseline population characteristics and precise interventions involved (particularly in terms of non-pharmacological interventions) that makes it difficult to draw conclusions from their meta-analysis</p>
|
||
<p>There is a lack of evidence measuring the long term effects of treatments for ADHD. As a chronic lifelong condition it is imperative trials have longer follow up measuring the benefits and risks of treatments.</p>
|
||
</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Equality</th><td headers="hd_b_ch6.appj.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Research could allow for recommendations tailored to age and not based on consensus and extrapolation from older children</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch6.appj.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Feasibility</th><td headers="hd_b_ch6.appj.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Key issue is that study needs to be large enough to be adequately powered and not to be another small comparison that does not fit in readily with previous evidence</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch6.appj.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td></tr><tr><th id="hd_b_ch6.appj.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Importance</th><td headers="hd_b_ch6.appj.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<ul id="ch6.l57"><li id="ch6.lt193" class="half_rhythm"><div>High: the research is essential to inform future updates of key recommendations in the guideline.</div></li></ul></td></tr></tbody></table></div></div></div></div></div><div class="bk_prnt_sctn"><h2>Tables</h2><div class="whole_rhythm bk_prnt_obj bk_first_prnt_obj"><div id="ch6.tab1" class="table"><h3><span class="label">Table 1</span><span class="title">PICO characteristics of review question</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab1_lrgtbl__"><table><tbody><tr><th id="hd_b_ch6.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><td headers="hd_b_ch6.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Children, young people and adults with ADHD.</p>
|
||
<p>Stratified by age:
|
||
<ul id="ch6.l1"><li id="ch6.lt1" class="half_rhythm"><div>Under 5 years</div></li><li id="ch6.lt2" class="half_rhythm"><div>5 to 18 years</div></li><li id="ch6.lt3" class="half_rhythm"><div>Over 18 years</div></li></ul></p>
|
||
</td></tr><tr><th id="hd_b_ch6.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention(s)</th><td headers="hd_b_ch6.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Pharmacological treatments (mixed, stimulants [including methylphenidate, dexamfetamine and lisdexamfetamine], atomoxetine, guanfacine)</p>
|
||
<p>Non-pharmacological treatments (parent/family/carer training, cognitive behavioural therapy (CBT), Dialectical behaviour therapy (DBT), psychoeducation, attention/memory/cognitive training, neurofeedback, relaxation techniques, organisational skills/school or workplace targeted interventions, exercise, outdoor activities, non-specific supportive therapy (NSST))</p>
|
||
<p>Combinations of pharmacological and non-pharmacological treatments</p>
|
||
</td></tr><tr><th id="hd_b_ch6.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparison(s)</th><td headers="hd_b_ch6.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Any pharmacological treatment versus any non-pharmacological treatment</p>
|
||
<p>Any combined treatment versus any pharmacological/non-pharmacological treatment alone</p>
|
||
<p>Any combined treatment versus any other combined treatment</p>
|
||
<p>Any combined treatment versus usual care</p>
|
||
</td></tr><tr><th id="hd_b_ch6.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes</th><td headers="hd_b_ch6.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<ul id="ch6.l2"><li id="ch6.lt4" class="half_rhythm"><div>Quality of life</div></li><li id="ch6.lt5" class="half_rhythm"><div>ADHD symptoms (total, inattention, hyperactivity, stratified by rater)</div></li><li id="ch6.lt6" class="half_rhythm"><div>Discontinuation due to intervention</div></li><li id="ch6.lt7" class="half_rhythm"><div>Serious adverse events</div></li><li id="ch6.lt8" class="half_rhythm"><div>Behavioural measures</div></li><li id="ch6.lt9" class="half_rhythm"><div>Emotional dysregulation</div></li><li id="ch6.lt10" class="half_rhythm"><div>Academic outcomes</div></li></ul></td></tr><tr><th id="hd_b_ch6.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch6.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs only</td></tr></tbody></table></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab2" class="table"><h3><span class="label">Table 2</span><span class="title">Summary of studies included in the evidence review for children aged over 5 to 18</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Intervention and comparison</th><th id="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Population</th><th id="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Comments</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Abikoff 2004<a class="bk_pop" href="#ch6.r3"><sup>3</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants alone (n = 34), 12 months</p>
|
||
<p>Stimulants + parent/family training (n = 34), 12 months</p>
|
||
<p>Stimulants + nonspecific supportive therapy (n = 35), 12 months</p>
|
||
<p>Follow-up to 2 years</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Aged 7 to 9.9 (mean 8.2)</p>
|
||
<p>Participants were all selected as responders to 5 weeks of open label methylphenidate</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dose 2016<a class="bk_pop" href="#ch6.r9"><sup>9</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + parent/family training (n = 51)</p>
|
||
<p>Stimulants (n = 52)</p>
|
||
<p>Follow-up and intervention duration 12 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Aged 6 to 12</p>
|
||
<p>Participants were previously using drugs for ADHD and not responding</p>
|
||
<p>Germany</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Behaviour/function</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>General ADHD population</p>
|
||
<p>Parent/family training predominantly delivered via mailed self-help manuals with telephone follow-up</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Duric 2014<a class="bk_pop" href="#ch6.r10"><sup>10</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + neurofeedback (n = 22)</p>
|
||
<p>Stimulants (n = 27)</p>
|
||
<p>Neurofeedback (n = 24)</p>
|
||
<p>Follow-up (estimated intervention duration) 10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Aged 6 to 17 (mean 11.5)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>Norway</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Academic</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Duric 2017<a class="bk_pop" href="#ch6.r11"><sup>11</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + neurofeedback (n=44), 3 months</p>
|
||
<p>Stimulants (n=42), 3 months</p>
|
||
<p>Neurofeedback (n=42), 3 months</p>
|
||
<p>Follow-up 6 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Aged 6 to 18 (mean 11.2)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>Norway</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Academic</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ferrin 2014<a class="bk_pop" href="#ch6.r17"><sup>17</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + psychoeducation (n = 40), 12 weeks</p>
|
||
<p>Mixed medication + non-specific supportive therapy (n = 36), 12 weeks</p>
|
||
<p>Follow-up to 15 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Aged 3 to 19 (mean 10.65)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>Spain</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Behaviour/function</p>
|
||
<p>Emotional dysregulation</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gelade 2016<a class="bk_pop" href="#ch6.r20"><sup>20</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants (n = 33)</p>
|
||
<p>Exercise (n = 37)</p>
|
||
<p>Follow-up and intervention duration to 10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 9.63 (SD 1.76)</p>
|
||
<p>All were free of stimulant use for at least 1 month</p>
|
||
<p>Netherlands</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Handen 2015<a class="bk_pop" href="#ch6.r21"><sup>21</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Atomoxetine + parent/family training (n = 32)</p>
|
||
<p>Atomoxetine (n = 32)</p>
|
||
<p>Parent/family training (n = 32)</p>
|
||
<p>Placebo/usual care (n = 32)</p>
|
||
<p>Follow-up and intervention duration 10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Aged 5 to 14 (mean age 8.1)</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Responders by CGI-I</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD and ASD</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hiscock 2015<a class="bk_pop" href="#ch6.r24"><sup>24</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + sleep intervention (n = 122)</p>
|
||
<p>Mixed medication (n = 122)</p>
|
||
<p>Follow-up and intervention duration 6 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Aged 5 to 12 years</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>Australia</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Behaviour/function</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lee 2017<a class="bk_pop" href="#ch6.r36"><sup>36</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + neurofeedback (n = 18)</p>
|
||
<p>Mixed medication (n = 18)</p>
|
||
<p>Follow-up and intervention duration 10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 8.7 (SD 2)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>South Korea</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Behaviour/function</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Li 2013<a class="bk_pop" href="#ch6.r38"><sup>38</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + neurofeedback (n = 31), 8-20 weeks</p>
|
||
<p>Stimulants + attention training (n = 29), 8-20 weeks</p>
|
||
<p>Follow-up to 6 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 10.6 (SD 2.8)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>China</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MTA study 1999<a class="bk_pop" href="#ch6.r1"><sup>1</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r28"><sup>28</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + parent/family training (n = 134), 14 months</p>
|
||
<p>Mixed medication (n = 120), 14 months</p>
|
||
<p>Parent/family training (n = 129), 14 months</p>
|
||
<p>Waitlist/usual care (n = 128)</p>
|
||
<p>Follow-up to 3 years</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 8.5 (SD 0.8)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Academic</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Merrill 2016<a class="bk_pop" href="#ch6.r41"><sup>41</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + parent/family training (n = 39)</p>
|
||
<p>Parent/family training (n = 36)</p>
|
||
<p>Mixed medication (n = 36)</p>
|
||
<p>Waitlist/usual care (n = 36)</p>
|
||
<p>Follow-up and intervention duration 2 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 8 (SD 1.7)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mohammadi 2014<a class="bk_pop" href="#ch6.r43"><sup>43</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + attention/memory/cognitive training (n = 23)</p>
|
||
<p>Stimulants (n = 25)</p>
|
||
<p>Follow-up to ~2 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Age range from 6 to 12</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>Iran</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Montoya 2014<a class="bk_pop" href="#ch6.r44"><sup>44</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + parent/family training (n = 144)</p>
|
||
<p>Mixed medication (n = 126)</p>
|
||
<p>Follow-up to 12 months (intervention duration unclear)</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 9.1 (SD 1.9)</p>
|
||
<p>Participants were pharmacologically naïve</p>
|
||
<p>Spain</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Riggs 2011<a class="bk_pop" href="#ch6.r50"><sup>50</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + CBT (n = 151)</p>
|
||
<p>CBT (n = 152)</p>
|
||
<p>Follow-up and intervention duration 4 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 16.5 (SD 1.3)</p>
|
||
<p>Participants had not used psychotropic medication in previous month</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Majority moderate severity</p>
|
||
<p>Comorbid non-tobacco substance use disorder</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">So 2008<a class="bk_pop" href="#ch6.r54"><sup>54</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + parent/family training (n = 45)</p>
|
||
<p>Stimulants (n = 31)</p>
|
||
<p>Follow-up to 18 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 8.0 (SD 0.9)</p>
|
||
<p>Participants were pharmacologically naïve</p>
|
||
<p>Hong Kong</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sprich 2016<a class="bk_pop" href="#ch6.r55"><sup>55</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + CBT (n = 46), 6 months</p>
|
||
<p>Mixed medication (n = 46), 6 months</p>
|
||
<p>Follow-up to 1 month</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 15.13 (SD 1.1)</p>
|
||
<p>Participants were previously using drugs for ADHD and not responding</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Storebo 2012<a class="bk_pop" href="#ch6.r56"><sup>56</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + parent/family training (n = 28)</p>
|
||
<p>Mixed medication (n = 27)</p>
|
||
<p>Follow-up and intervention duration 6 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Age range 8 to 12</p>
|
||
<p>Participants were pharmacologically naïve</p>
|
||
<p>Denmark</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Behaviour/function</p>
|
||
<p>Emotional dysregulation Academic</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Svanborg 2009<a class="bk_pop" href="#ch6.r59"><sup>59</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Atomoxetine + psychoeducation (n = 49)</p>
|
||
<p>Psychoeducation (n = 50)</p>
|
||
<p>Follow-up and intervention duration 10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Age range 6 to 15</p>
|
||
<p>Participants were pharmacologically naïve</p>
|
||
<p>Sweden</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Quality of life</p>
|
||
<p>ADHD symptoms</p>
|
||
<p>Academic</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Thurstone 2010<a class="bk_pop" href="#ch6.r61"><sup>61</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Atomoxetine + CBT (n = 32)</p>
|
||
<p>CBT (n = 33)</p>
|
||
<p>Follow-up and intervention duration 3 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 16.1 (SD 1.6)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Responders by CGI-I</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comorbid non-tobacco substance use disorder</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Van der Oord<a class="bk_pop" href="#ch6.r62"><sup>62</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + parent/family training (n = 24)</p>
|
||
<p>Stimulants (n = 21)</p>
|
||
<p>Follow-up and intervention duration 10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 9.9 (SD 1.2)</p>
|
||
<p>Participants were pharmacologically naïve</p>
|
||
<p>Netherlands</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Vidal 2015<a class="bk_pop" href="#ch6.r63"><sup>63</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + CBT (n = 59)</p>
|
||
<p>Mixed medication (n = 60)</p>
|
||
<p>Follow-up and intervention duration to ~3 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 17.47 (SD 1.88)</p>
|
||
<p>Participants were previously treated with ADHD medication, response not specified</p>
|
||
<p>Spain</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Waxmonsky 2010<a class="bk_pop" href="#ch6.r65"><sup>65</sup></a></td><td headers="hd_h_ch6.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Atomoxetine + parent/family training (n = 29)</p>
|
||
<p>Atomoxetine (n = 27)</p>
|
||
<p>Follow-up and intervention duration 2 months</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 8.59 (SD 1.58)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Responders by CGI-I</p>
|
||
<p>Behaviour/function</p>
|
||
</td><td headers="hd_h_ch6.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr></tbody></table></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab3" class="table"><h3><span class="label">Table 3</span><span class="title">Summary of studies included in the evidence review for adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab3_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Intervention and comparison</th><th id="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Population</th><th id="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Comments</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emilsson 2011<a class="bk_pop" href="#ch6.r12"><sup>12</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + CBT (n = 15), 8 weeks</p>
|
||
<p>Mixed medication (n = 17), 8 weeks</p>
|
||
<p>Follow-up to ~5 months</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 33.88 (SD 11.47)</p>
|
||
<p>Participants were previously treated with ADHD medication, with persistent symptoms</p>
|
||
<p>Iceland</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Estrada 2013<a class="bk_pop" href="#ch6.r13"><sup>13</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + CBT (n = 15)</p>
|
||
<p>Mixed medication + non-specific supportive therapy (n = 17)</p>
|
||
<p>Follow-up and intervention duration 3 months</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 39.47 (SD 7.68)</p>
|
||
<p>Participants were previously treated with ADHD medication, partially responsive</p>
|
||
<p>Spain</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Quality of life</p>
|
||
<p>ADHD symptoms</p>
|
||
<p>Emotional dysregulation</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Jans 2015<a class="bk_pop" href="#ch6.r26"><sup>26</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + CBT + parent/family training (n = 77)</p>
|
||
<p>Non-specific supportive therapy + parent/family training (n = 66)</p>
|
||
<p>Follow-up and intervention duration 1 year</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 38.32 (SD 5.69)</p>
|
||
<p>Participants were not previously treated with methylphenidate or psychotherapy</p>
|
||
<p>Germany</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms (maternal)</p>
|
||
<p>ADHD symptoms (child)</p>
|
||
<p>Emotional dysregulation</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mothers with ADHD, with children with ADHD (treatment aimed at mothers)</p>
|
||
<p>Both groups received parent/family training after a period of either stimulant and CBT treatment or non-specific supportive treatment</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Konstenius 2014<a class="bk_pop" href="#ch6.r34"><sup>34</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + CBT (n = 27)</p>
|
||
<p>CBT (n = 26)</p>
|
||
<p>Follow-up and intervention duration 6 months</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 41.5 (SD 9.83)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>Sweden</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Participants from medium security prisons with comorbid amphetamine dependence</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Levin 2007<a class="bk_pop" href="#ch6.r37"><sup>37</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + CBT (n = 53)</p>
|
||
<p>CBT (n = 53)</p>
|
||
<p>Follow-up and intervention duration 14 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 37 (SD 6.5)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Responders by CGI-I</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comorbid cocaine dependence</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Philipsen 2015<a class="bk_pop" href="#ch6.r49"><sup>49</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + CBT (n = 103)</p>
|
||
<p>Stimulants + non-specific supportive therapy (n = 110)</p>
|
||
<p>Placebo + CBT (n = 107)</p>
|
||
<p>Placebo + non-specific supportive therapy (n = 103)</p>
|
||
<p>Follow-up and intervention duration 1 year</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 35 (SD 10.26)</p>
|
||
<p>Participants had not used stimulants for ADHD or psychotherapy aimed at ADHD in preceding 6 months</p>
|
||
<p>Germany</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Emotional dysregulation</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Safren 2005<a class="bk_pop" href="#ch6.r51"><sup>51</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + CBT (n = 16)</p>
|
||
<p>Mixed medication (n = 15)</p>
|
||
<p>Follow-up and intervention duration 15 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 45.5 (SD 10.6)</p>
|
||
<p>Participants were previously using ADHD medication and responsive but with persistent symptoms</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Emotional dysregulation</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Safren 2010<a class="bk_pop" href="#ch6.r52"><sup>52</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + CBT (n = 38), 15 weeks</p>
|
||
<p>Mixed medication + non-specific supportive therapy (n = 32), 15 weeks</p>
|
||
<p>Follow-up to ~18 months</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 43.2 (SD 11.3)</p>
|
||
<p>Participants were previously using medication for ADHD and had persistent symptoms</p>
|
||
<p>USA</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>CGI-I responders</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Weiss 2012<a class="bk_pop" href="#ch6.r66"><sup>66</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Stimulants + CBT (n = 23), 14 weeks</p>
|
||
<p>CBT (n = 25)</p>
|
||
<p>Follow-up to 5 months, 14 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 35.6 (SD 9.9)</p>
|
||
<p>Not selected based on previous treatment or response</p>
|
||
<p>USA and Canada</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ADHD symptoms</p>
|
||
<p>Responders by CGI-I</p>
|
||
<p>Emotional dysregulation</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr><tr><td headers="hd_h_ch6.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Young 2015<a class="bk_pop" href="#ch6.r67"><sup>67</sup></a><sup>,</sup><a class="bk_pop" href="#ch6.r68"><sup>68</sup></a></td><td headers="hd_h_ch6.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mixed medication + CBT (n = 25)</p>
|
||
<p>Mixed medication (n = 32)</p>
|
||
<p>Follow-up and intervention duration 3 months</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Mean age 35.2 (SD 11.7)</p>
|
||
<p>Previously on medication for ADHD, response not specified</p>
|
||
<p>Iceland</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Quality of life</p>
|
||
<p>ADHD symptoms</p>
|
||
<p>Emotional dysregulation Behaviour/function</p>
|
||
</td><td headers="hd_h_ch6.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General ADHD population</td></tr></tbody></table></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab4" class="table"><h3><span class="label">Table 4</span><span class="title">Clinical evidence summary: Atomoxetine versus parent/family training</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab4_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab4_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab4_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab4_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab4_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab4_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab4_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab4_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab4_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab4_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab4_1_1_1_5" id="hd_h_ch6.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with PT/FT</th><th headers="hd_h_ch6.tab4_1_1_1_5" id="hd_h_ch6.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Atomoxetine (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab4_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab4_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.45</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.21 lower</p>
|
||
<p>(0.5 lower to 0.08 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab4_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab4_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.46</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.03 higher</p>
|
||
<p>(0.35 lower to 0.41 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab4_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab4_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.44</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.32 lower</p>
|
||
<p>(0.68 lower to 0.04 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab4_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab4_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.28</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.04 higher</p>
|
||
<p>(0.43 lower to 0.51 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab4_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab4_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.45</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.09 lower</p>
|
||
<p>(0.41 lower to 0.23 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab4_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab4_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.64</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.02 higher</p>
|
||
<p>(0.37 lower to 0.41 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months)</td><td headers="hd_h_ch6.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>63</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab4_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab4_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 1.61</p>
|
||
<p>(0.83 to 3.13)</p>
|
||
</td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">290 per 1000</td><td headers="hd_h_ch6.tab4_1_1_1_5 hd_h_ch6.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>177 more per 1000</p>
|
||
<p>(from 49 fewer to 618 more)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab4_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab4_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab5" class="table"><h3><span class="label">Table 5</span><span class="title">Clinical evidence summary: Stimulants versus exercise</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab5_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab5_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab5_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab5_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab5_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab5_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab5_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab5_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab5_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab5_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab5_1_1_1_5" id="hd_h_ch6.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Exercise</th><th headers="hd_h_ch6.tab5_1_1_1_5" id="hd_h_ch6.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SWAN, 0-3, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>73</p>
|
||
<p>(1 study)</p>
|
||
<p>10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab5_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab5_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab5_1_1_1_5 hd_h_ch6.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, swan, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.07</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_5 hd_h_ch6.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, swan, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.45 lower</p>
|
||
<p>(0.84 to 0.06 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SWAN,0-3, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>70</p>
|
||
<p>(1 study)</p>
|
||
<p>10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab5_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab5_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab5_1_1_1_5 hd_h_ch6.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, swan, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.1</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_5 hd_h_ch6.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, swan, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.87 lower</p>
|
||
<p>(1.3 to 0.44 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SWAN, 0-3, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>73</p>
|
||
<p>(1 study)</p>
|
||
<p>10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab5_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab5_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab5_1_1_1_5 hd_h_ch6.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, swan, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.11</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_5 hd_h_ch6.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, swan, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.50 lower</p>
|
||
<p>(0.86 to 0.14 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>70</p>
|
||
<p>(1 study)</p>
|
||
<p>10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab5_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab5_1_1_1_5 hd_h_ch6.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, swan, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.33</p>
|
||
</td><td headers="hd_h_ch6.tab5_1_1_1_5 hd_h_ch6.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, swan, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.76 lower</p>
|
||
<p>(1.12 to 0.4 lower)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab5_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab5_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab6" class="table"><h3><span class="label">Table 6</span><span class="title">Clinical evidence summary: Stimulants versus Neurofeedback</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab6_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab6_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab6_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab6_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab6_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab6_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab6_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab6_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab6_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab6_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab6_1_1_1_5" id="hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with NF</th><th headers="hd_h_ch6.tab6_1_1_1_5" id="hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>23.5</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>4.60 higher</p>
|
||
<p>(0.46 to 8.74 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>23.8</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.30 lower</p>
|
||
<p>(5.21 lower to 4.61 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>21</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.70 higher</p>
|
||
<p>(2.93 lower to 8.33 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>25.3</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.80 higher</p>
|
||
<p>(4.45 lower to 6.05 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>9.2</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>3.00 higher</p>
|
||
<p>(0.49 to 5.51 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>10</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>1.40 higher</p>
|
||
<p>(1.43 lower to 4.23 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SWAN, 0-3, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, swan, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.02</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, swan, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.40 lower</p>
|
||
<p>(0.79 to 0.01 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>10.8</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.40 higher</p>
|
||
<p>(3.33 lower to 4.13 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s,0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>10.5</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>2.50 higher</p>
|
||
<p>(0.59 lower to 5.59 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>72</p>
|
||
<p>(1 study)</p>
|
||
<p>10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, swan, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.16</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, swan, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.93 lower</p>
|
||
<p>(1.39 to 0.47 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, srq, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>1.4</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, srq, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.10 lower</p>
|
||
<p>(1.63 lower to 1.43 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>5.8</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.60 higher</p>
|
||
<p>(0.90 lower to 2.10 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, FU, >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>5.8</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.10 higher</p>
|
||
<p>(1.18 lower to 1.38 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>14.3</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>1.60 higher</p>
|
||
<p>(0.91 lower to 4.11 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>13.9</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>1.80 lower</p>
|
||
<p>(4.42 lower to 0.82 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SWAN, 0-3, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, swan, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.11</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, swan, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.50 lower</p>
|
||
<p>(0.84 to 0.16 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>10.2</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.30 higher</p>
|
||
<p>(0.55 lower to 5.15 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>14.8</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>1.70 lower</p>
|
||
<p>(4.53 lower to 1.13 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SWAN, 0-3, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>72</p>
|
||
<p>(1 study)</p>
|
||
<p>10-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, swan, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.3</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, swan, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.73 lower</p>
|
||
<p>(1.09 to 0.37 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>6.5</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.20 higher</p>
|
||
<p>(1.02 lower to 1.42 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, FU, >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>5.6</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.40 higher</p>
|
||
<p>(0.68 lower to 1.48 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, srq, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>1.8</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, srq, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.40 lower</p>
|
||
<p>(1.75 lower to 0.95 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>51</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>1.5</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>1.40 lower</p>
|
||
<p>(3.22 lower to 0.42 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, PT <3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt <3 months) in the control groups was</p>
|
||
<p>5.8</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt <3 months) in the intervention groups was</p>
|
||
<p>0.60 higher</p>
|
||
<p>(0.90 lower to 2.10 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, FU >3 months)</td><td headers="hd_h_ch6.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab6_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab6_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt >3 months) in the control groups was</p>
|
||
<p>5.8</p>
|
||
</td><td headers="hd_h_ch6.tab6_1_1_1_5 hd_h_ch6.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt >3 months) in the intervention groups was</p>
|
||
<p>0.10 higher</p>
|
||
<p>(1.18 lower to 1.38 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab6_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab6_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab6_3"><p class="no_margin">Downgraded by 2 increments if the confidence interval crossed both MIDs.</p></div></dd><dt>(d)</dt><dd><div id="ch6.tab6_4"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab7" class="table"><h3><span class="label">Table 7</span><span class="title">Clinical evidence summary: Stimulants + non-specific supportive therapy versus stimulants</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab7_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab7_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab7_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab7_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab7_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab7_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab7_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab7_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab7_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab7_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab7_1_1_1_5" id="hd_h_ch6.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Stimulants</th><th headers="hd_h_ch6.tab7_1_1_1_5" id="hd_h_ch6.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + NSST (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, PT >3 months)</td><td headers="hd_h_ch6.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>39</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab7_1_1_1_5 hd_h_ch6.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.1</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_5 hd_h_ch6.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.10 lower</p>
|
||
<p>(0.38 lower to 0.18 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)</td><td headers="hd_h_ch6.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>69</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab7_1_1_1_5 hd_h_ch6.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, fu >3 months) in the control groups was</p>
|
||
<p>1</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_5 hd_h_ch6.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.20 lower</p>
|
||
<p>(0.44 lower to 0.04 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)</td><td headers="hd_h_ch6.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>69</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab7_1_1_1_5 hd_h_ch6.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.2</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_5 hd_h_ch6.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.30 lower</p>
|
||
<p>(0.68 lower to 0.08 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)</td><td headers="hd_h_ch6.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>69</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab7_1_1_1_5 hd_h_ch6.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, fu >3 months) in the control groups was</p>
|
||
<p>1.1</p>
|
||
</td><td headers="hd_h_ch6.tab7_1_1_1_5 hd_h_ch6.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.40 lower</p>
|
||
<p>(0.7 to 0.1 lower)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab7_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab7_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab8" class="table"><h3><span class="label">Table 8</span><span class="title">Clinical evidence summary: Mixed medication versus parent/family training</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab8_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab8_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab8_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab8_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab8_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab8_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab8_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab8_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab8_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab8_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab8_1_1_1_5" id="hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with parent/family training</th><th headers="hd_h_ch6.tab8_1_1_1_5" id="hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Mixed medication (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>242</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher and parent, snap, 0-3, high is poor, fv, fu >3 months) in the control groups was</p>
|
||
<p>1.27</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher and parent, snap, 0-3, high is poor, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.06 lower</p>
|
||
<p>(0.21 lower to 0.09 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>239</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, 0-3, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>1.1</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, 0-3, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.28 lower</p>
|
||
<p>(0.47 to 0.09 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>250</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, 0-3, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.24</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, 0-3, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.33 lower</p>
|
||
<p>(0.5 to 0.16 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>217</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, snap, 0-3, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>0.29</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, snap, 0-3,high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.13 lower</p>
|
||
<p>(0.19 to 0.07 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>250</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, 0-3, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.4</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, 0-3, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.28 lower</p>
|
||
<p>(0.45 to 0.11 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>240</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, 0-3, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.47</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, 0-3, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.36 lower</p>
|
||
<p>(0.56 to 0.16 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>78</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab8_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy %, observer, high is better, pt <3 months) in the control groups was</p>
|
||
<p>91.9</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy %, observer, high is better, pt <3 months) in the intervention groups was</p>
|
||
<p>4.14 lower</p>
|
||
<p>(7.04 to 1.24 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>258</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the control groups was</p>
|
||
<p>100.3</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the intervention groups was</p>
|
||
<p>0.60 lower</p>
|
||
<p>(3.86 lower to 2.66 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab7_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab8_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy %, observer, high is better, pt <3 months) in the control groups was</p>
|
||
<p>91.59</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy %, observer,high is better, pt <3 months) in the intervention groups was</p>
|
||
<p>5.45 lower</p>
|
||
<p>(9.36 to 1.54 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>258</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the control groups was</p>
|
||
<p>96.2</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the intervention groups was</p>
|
||
<p>1.70 higher</p>
|
||
<p>(1.84 lower to 5.24 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)</td><td headers="hd_h_ch6.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>242</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab7_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, fu >3 months) in the control groups was</p>
|
||
<p>98.3</p>
|
||
</td><td headers="hd_h_ch6.tab8_1_1_1_5 hd_h_ch6.tab8_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, fu >3 months) in the intervention groups was</p>
|
||
<p>0.50 lower</p>
|
||
<p>(3.98 lower to 2.98 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab8_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab8_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab8_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab9" class="table"><h3><span class="label">Table 9</span><span class="title">Clinical evidence summary: Atomoxetine + parent/family training versus parent/family training</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab9/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab9_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab9_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab9_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab9_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab9_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab9_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab9_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab9_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab9_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab9_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab9_1_1_1_5" id="hd_h_ch6.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with parent/family training</th><th headers="hd_h_ch6.tab9_1_1_1_5" id="hd_h_ch6.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Atomoxetine + PT/FT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab9_3">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab9_4">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.45</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.22 lower</p>
|
||
<p>(0.54 lower to 0.1 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab9_3">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab9_4">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms</p>
|
||
<p>(total, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.46</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.32 lower</p>
|
||
<p>(0.72 lower to 0.08 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab9_3">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab9_4">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.44</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.29 lower</p>
|
||
<p>(0.65 lower to 0.07 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab9_3">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab9_4">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.28</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.30 lower</p>
|
||
<p>(0.77 lower to 0.17 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab9_3">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab9_4">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.45</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.15 lower</p>
|
||
<p>(0.5 lower to 0.2 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab9_3">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab9_4">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.64</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.34 lower</p>
|
||
<p>(0.75 lower to 0.07 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months)</td><td headers="hd_h_ch6.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>62</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab9_3">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab9_4">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 1.67</p>
|
||
<p>(0.86 to 3.22)</p>
|
||
</td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">290 per 1000</td><td headers="hd_h_ch6.tab9_1_1_1_5 hd_h_ch6.tab9_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>194 more per 1000</p>
|
||
<p>(from 41 fewer to 644 more)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.tab9_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.tab9_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab9_3"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab9_4"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab10" class="table"><h3><span class="label">Table 10</span><span class="title">Clinical evidence summary: Atomoxetine + PE versus PE</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab10/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab10_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab10_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab10_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab10_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab10_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab10_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab10_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab10_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab10_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab10_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab10_1_1_1_5" id="hd_h_ch6.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with PE</th><th headers="hd_h_ch6.tab10_1_1_1_5" id="hd_h_ch6.tab10_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Atomoxetine + PE (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life (parent rated, total CHIP-CE, unclear range, high is good outcome, CS, PT <3 months)</td><td headers="hd_h_ch6.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>99</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab10_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean quality of life (parent rated, total chip-ce, unclear range, high is good outcome, cs, pt <3 months) in the control groups was</p>
|
||
<p>5.2</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean quality of life (parent rated, total chip-ce, unclear range, high is good outcome, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>1.40 higher</p>
|
||
<p>(1.93 lower to 4.73 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)</td><td headers="hd_h_ch6.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>99</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HIGH</td><td headers="hd_h_ch6.tab10_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, high is poor, cs, pt, <3 months) in the control groups was</p>
|
||
<p>−6.3</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, high is poor, cs, pt, <3 months) in the intervention groups was</p>
|
||
<p>12.70 lower</p>
|
||
<p>(16.86 to 8.54 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)</td><td headers="hd_h_ch6.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>99</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HIGH</td><td headers="hd_h_ch6.tab10_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ADHD-rs, high is poor, cs, pt, <3 months) in the control groups was</p>
|
||
<p>−2.5</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ADHD-rs, high is poor, cs, pt, <3 months) in the intervention groups was</p>
|
||
<p>6.20 lower</p>
|
||
<p>(8.42 to 3.98 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS, 0-25, high is poor, CS, PT, <3 months)</td><td headers="hd_h_ch6.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>99</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HIGH</td><td headers="hd_h_ch6.tab10_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, ADHD-rs, high is poor, cs, pt, <3 months) in the control groups was</p>
|
||
<p>−3.8</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, ADHD-rs, high is poor, cs, pt, <3 months) in the intervention groups was</p>
|
||
<p>6.50 lower</p>
|
||
<p>(8.5 to 4.5 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (parent rated, academic CHIP-CE, unclear range, high is good outcome, CS, PT <3 months)</td><td headers="hd_h_ch6.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>99</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab10_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (parent rated, academic chip-ce, unclear range, high is good outcome, cs, pt <3 months) in the control groups was</p>
|
||
<p>2.4</p>
|
||
</td><td headers="hd_h_ch6.tab10_1_1_1_5 hd_h_ch6.tab10_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (parent rated, academic chip-ce, unclear range, high is good outcome, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>4.30 higher</p>
|
||
<p>(0.83 to 7.77 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab10_1"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab11" class="table"><h3><span class="label">Table 11</span><span class="title">Clinical evidence summary: Atomoxetine + CBT versus CBT</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab11/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab11_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab11_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab11_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab11_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab11_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab11_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab11_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab11_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab11_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab11_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab11_1_1_1_5" id="hd_h_ch6.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with CBT</th><th headers="hd_h_ch6.tab11_1_1_1_5" id="hd_h_ch6.tab11_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Atomoxetine + CBT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, DSM-IV checklist, 0-54, high is poor, CS, PT <3 months)</td><td headers="hd_h_ch6.tab11_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>65</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab11_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab11_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab11_1_1_1_5 hd_h_ch6.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, dsm-iv checklist, 0-54, high is poor, cs, pt <3 months) in the control groups was</p>
|
||
<p>8.82</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_5 hd_h_ch6.tab11_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, dsm-iv checklist, 0-54, high is poor, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>5.00 higher</p>
|
||
<p>(1.87 lower to 11.87 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, DSM-IV checklist, 0-54, high is poor, CS, PT <3 months)</td><td headers="hd_h_ch6.tab11_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>65</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab11_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab11_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab11_1_1_1_5 hd_h_ch6.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, dsm-iv checklist, 0-54, high is poor, cs, pt <3 months) in the control groups was</p>
|
||
<p>19.02</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_5 hd_h_ch6.tab11_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, dsm-iv checklist, 0-54, high is poor, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.83 lower</p>
|
||
<p>(7.52 lower to 5.86 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab11_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months)</td><td headers="hd_h_ch6.tab11_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>65</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab11_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab11_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 0.88</p>
|
||
<p>(0.57 to 1.34)</p>
|
||
</td><td headers="hd_h_ch6.tab11_1_1_1_5 hd_h_ch6.tab11_1_1_2_1 hd_h_ch6.tab11_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab11_1_1_1_5 hd_h_ch6.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">606 per 1000</td><td headers="hd_h_ch6.tab11_1_1_1_5 hd_h_ch6.tab11_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>73 fewer per 1000</p>
|
||
<p>(from 261 fewer to 206 more)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab11_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab11_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab11_3"><p class="no_margin">Downgraded by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab12" class="table"><h3><span class="label">Table 12</span><span class="title">Clinical evidence summary: Stimulants + NF versus NF</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab12/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab12_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab12_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab12_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab12_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab12_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab12_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab12_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab12_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab12_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab12_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab12_1_1_1_5" id="hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with NF</th><th headers="hd_h_ch6.tab12_1_1_1_5" id="hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + NF (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>23.5</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>1.10 higher</p>
|
||
<p>(3.03 lower to 5.23 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>23.8</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>1.10 lower</p>
|
||
<p>(6.01 lower to 3.81 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, <3 months) in the</p>
|
||
<p>control groups was</p>
|
||
<p>21</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.10 higher</p>
|
||
<p>(5.87 lower to 6.07 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>25.3</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>3.20 lower</p>
|
||
<p>(8.73 lower to 2.33 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>9.2</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.30 higher</p>
|
||
<p>(2.21 lower to 2.81 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>10</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.90 higher</p>
|
||
<p>(2.00 lower to 3.80 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>10.8</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.10 lower</p>
|
||
<p>(6.03 lower to 1.83 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>10.5</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.00 higher</p>
|
||
<p>(3.24 lower to 3.24 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, PT, <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>5.8</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>1.20 higher</p>
|
||
<p>(0.36 lower to 2.76 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is good, FU, >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>5.8</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.10 higher</p>
|
||
<p>(1.18 lower to 1.38 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>50</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, srq, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>1.4</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, srq, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.40 lower</p>
|
||
<p>(2 lower to 1.2 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>14.3</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.80 higher</p>
|
||
<p>(1.71 lower to 3.31 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>13.9</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>2.10 lower</p>
|
||
<p>(4.79 lower to 0.59 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>10.2</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.20 higher</p>
|
||
<p>(0.78 lower to 5.18 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>14.8</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>3.20 lower</p>
|
||
<p>(6.17 to 0.23 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, PT, <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>6.5</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.20 lower</p>
|
||
<p>(1.42 lower to 1.02 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is good, FU, >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>5.6</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>1.30 higher</p>
|
||
<p>(0.22 to 2.38 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>50</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, srq, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>1.8</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, srq, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.60 lower</p>
|
||
<p>(1.88 lower to 0.68 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>46</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>1.5</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>2.50 lower</p>
|
||
<p>(4.31 to 0.69 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, PT <3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt <3 months) in the control groups was</p>
|
||
<p>5.8</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt <3 months) in the intervention groups was</p>
|
||
<p>1.20 higher</p>
|
||
<p>(0.36 lower to 2.76 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, FU >3 months)</td><td headers="hd_h_ch6.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab12_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab12_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt >3 months) in the control groups was</p>
|
||
<p>5.8</p>
|
||
</td><td headers="hd_h_ch6.tab12_1_1_1_5 hd_h_ch6.tab12_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt >3 months) in the intervention groups was</p>
|
||
<p>0.10 higher</p>
|
||
<p>(1.18 lower to 1.38 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab12_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab12_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab12_3"><p class="no_margin">Downgraded by 2 increments if the confidence interval crosses 2 MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab13" class="table"><h3><span class="label">Table 13</span><span class="title">Clinical evidence summary: Stimulants + CBT versus CBT</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab13/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab13_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.tab13_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab13_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab13_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab13_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab13_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab13_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab13_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab13_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab13_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab13_1_1_1_5" id="hd_h_ch6.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with CBT</th><th headers="hd_h_ch6.tab13_1_1_1_5" id="hd_h_ch6.tab13_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + CBT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, ADHD-RS, 0-68, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab13_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>303</p>
|
||
<p>(1 study)</p>
|
||
<p>16 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab13_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HIGH</td><td headers="hd_h_ch6.tab13_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab13_1_1_1_5 hd_h_ch6.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, ADHD-rs, 0-68, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>16.4</p>
|
||
</td><td headers="hd_h_ch6.tab13_1_1_1_5 hd_h_ch6.tab13_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, ADHD-rs, 0-68, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.60 higher</p>
|
||
<p>(1.04 lower to 2.24 higher)</p>
|
||
</td></tr></tbody></table></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab14" class="table"><h3><span class="label">Table 14</span><span class="title">Clinical evidence summary: Mixed medication + PT/FT versus PT/FT</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab14/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab14_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab14_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab14_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab14_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab14_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab14_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab14_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab14_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab14_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab14_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab14_1_1_1_5" id="hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with PF/FT</th><th headers="hd_h_ch6.tab14_1_1_1_5" id="hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Mixed medication + PT/FT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>254</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab14_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher and parent, snap, high is poor, fv, fu >3 months) in the control groups was</p>
|
||
<p>1.27</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher and parent, snap, high is poor, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.07 lower</p>
|
||
<p>(0.21 lower to 0.07 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>253</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab14_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab14_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>1.1</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.35 lower</p>
|
||
<p>(0.53 to 0.17 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>262</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab14_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.24</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.61 higher</p>
|
||
<p>(0.45 to 0.77 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>221</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab14_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab14_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>0.29</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.08 lower</p>
|
||
<p>(0.14 to 0.02 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>262</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab14_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab14_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.4</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.38 lower</p>
|
||
<p>(0.54 to 0.22 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>254</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab14_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab14_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.47</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.35 lower</p>
|
||
<p>(0.54 to 0.16 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy %, high is better, observer, PT <3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>78</p>
|
||
<p>(1 study)</p>
|
||
<p>8 days</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab14_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab14_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy %, observer, high is better, pt <3 months) in the control groups was</p>
|
||
<p>91.89</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy %, observer, high is better, pt <3 months) in the intervention groups was</p>
|
||
<p>0.99 lower</p>
|
||
<p>(3.42 lower to 1.44 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>270</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab14_3">c</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy, observer, WIAT, 0-132,high is better, pt >3 months) in the control groups was</p>
|
||
<p>100.3</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy, observer, WIAT, 0-132,high is better, pt >3 months) in the intervention groups was</p>
|
||
<p>0.20 higher</p>
|
||
<p>(3.4 lower to 3.8 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab14_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab14_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy %, observer, high is better, pt <3 months) in the control groups was</p>
|
||
<p>91.59</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy %, observer, high is better, pt <3 months) in the intervention groups was</p>
|
||
<p>1.17 lower</p>
|
||
<p>(4.34 lower to 2 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>270</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab14_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the control groups was</p>
|
||
<p>96.2</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132,high is better, pt >3 months) in the intervention groups was</p>
|
||
<p>3.20 higher</p>
|
||
<p>(0.39 lower to 6.79 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)</td><td headers="hd_h_ch6.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>254</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab14_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132,high is better, fu >3 months) in the control groups was</p>
|
||
<p>98.3</p>
|
||
</td><td headers="hd_h_ch6.tab14_1_1_1_5 hd_h_ch6.tab14_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132,high is better, fu >3 months) in the intervention groups was</p>
|
||
<p>0.60 lower</p>
|
||
<p>(4.02 lower to 2.82 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab14_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab14_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab14_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab15" class="table"><h3><span class="label">Table 15</span><span class="title">Clinical evidence summary: Atomoxetine + PT/FT versus atomoxetine</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab15/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab15_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab15_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab15_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab15_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab15_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab15_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab15_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab15_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab15_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab15_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab15_1_1_1_5" id="hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Atomoxetine</th><th headers="hd_h_ch6.tab15_1_1_1_5" id="hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Atomoxetine + PT/FT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab15_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab15_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.24</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.01 lower</p>
|
||
<p>(0.32 lower to 0.3 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab15_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab15_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.49</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.35 lower</p>
|
||
<p>(0.73 lower to 0.03 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, multiple scales, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>120</p>
|
||
<p>(2 studies)</p>
|
||
<p>8-10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab15_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab15_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, multiple scales, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.19</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, multiple scales, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.21 standard deviations lower</p>
|
||
<p>(0.57 lower to 0.15 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, multiple scales, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>120</p>
|
||
<p>(2 studies)</p>
|
||
<p>8-10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab15_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab15_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, multiple scales, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.13</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, multiple scales, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.16 standard deviations lower</p>
|
||
<p>(0.52 lower to 0.2 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, multiple scales, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>120</p>
|
||
<p>(2 studies)</p>
|
||
<p>8-10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab15_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab15_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, multiple scales, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.50</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, multiple scales, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.37 standard deviations lower</p>
|
||
<p>(0.73 to 0.01 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, multiple scales, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>120</p>
|
||
<p>(2 studies)</p>
|
||
<p>8-10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab15_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab15_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, multiple scales, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.52</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, multiple scales, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.38 standard deviations lower</p>
|
||
<p>(0.74 to 0.02 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab15_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (PT, <3 months)</td><td headers="hd_h_ch6.tab15_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>119</p>
|
||
<p>(2 studies)</p>
|
||
<p>8-10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab15_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab15_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 1.05</p>
|
||
<p>(0.73 to 1.5)</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1 hd_h_ch6.tab15_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">494 per 1000</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>25 more per 1000</p>
|
||
<p>(from 133 fewer to 247 more)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (behaviour, 0-100, high is good, teacher, PT, <3 months)</td><td headers="hd_h_ch6.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>56</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab15_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab15_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (behaviour, 0-100, high is good, teacher, pt, <3 months) in the control groups was</p>
|
||
<p>77.84</p>
|
||
</td><td headers="hd_h_ch6.tab15_1_1_1_5 hd_h_ch6.tab15_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (behaviour, 0-100, high is good, teacher, pt, <3 months) in the intervention groups was</p>
|
||
<p>5.06 higher</p>
|
||
<p>(4.59 lower to 14.71 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab15_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab15_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab15_3"><p class="no_margin">Downgraded by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab16" class="table"><h3><span class="label">Table 16</span><span class="title">Clinical evidence summary: Stimulants + PT/FT versus stimulants</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab16/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab16_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab16_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab16_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab16_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab16_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab16_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab16_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab16_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab16_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab16_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab16_1_1_1_5" id="hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Stimulants</th><th headers="hd_h_ch6.tab16_1_1_1_5" id="hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + PT/FT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, multiple scales, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>224</p>
|
||
<p>(3 studies)</p>
|
||
<p>2-12 months</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab16_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab16_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, multiple scales, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>4.44</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, multiple scales, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.42 standard deviations lower</p>
|
||
<p>(0.69 to 0.15 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SWAN, 0-3, high is poor, FV, FU, >3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab16_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab16_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, swan, 0-3, high is poor, fv, fu, >3 months) in the control groups was</p>
|
||
<p>0.71</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, swan, 0-3, high is poor, fv, fu, >3 months) in the intervention groups was</p>
|
||
<p>0.13 lower</p>
|
||
<p>(0.39 lower to 0.13 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, DBDRS, 0-54, high is poor, FV, PT, <3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>45</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab16_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab16_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, dbdrs, 0-54, high is poor, fv, pt, <3 months) in the control groups was</p>
|
||
<p>13.75</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, dbdrs, 0-54, high is poor, fv, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.15 higher</p>
|
||
<p>(3.48 lower to 7.78 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, FBB-ADHS, 0-3, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>137</p>
|
||
<p>(2 studies)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab16_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, fbbadhs, 0-3, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>1.26</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, fbbadhs, 0-3, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.05 standard deviations lower</p>
|
||
<p>(0.35 lower to 0.25 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>68</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab16_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab16_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, fu >3 months) in the control groups was</p>
|
||
<p>1</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.10 lower</p>
|
||
<p>(0.36 lower to 0.16 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>68</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab16_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab16_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.2</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.30 lower</p>
|
||
<p>(0.7 lower to 0.1 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>68</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab16_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab16_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, fu >3 months) in the control groups was</p>
|
||
<p>1.1</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.10 lower</p>
|
||
<p>(0.46 lower to 0.26 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, FBB-ADHS, 0-3, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>103</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab16_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab16_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, fbb-adhs, 0-3, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>1.67</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, fbb-adhs, 0-3, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.29 lower</p>
|
||
<p>(0.53 to 0.05 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (function, parent, WFIRS-P, 0-3, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>103</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab16_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab16_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (function, parent, wfirs-p, 0-3, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>0.96</p>
|
||
</td><td headers="hd_h_ch6.tab16_1_1_1_5 hd_h_ch6.tab16_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (function, parent, wfirs-p, 0-3, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.10 lower</p>
|
||
<p>(0.3 lower to 0.1 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab16_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab16_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab16_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab17" class="table"><h3><span class="label">Table 17</span><span class="title">Clinical evidence summary: Stimulants + PT/FT versus stimulants + NSST</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab17/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab17_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab17_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab17_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab17_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab17_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab17_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab17_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab17_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab17_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab17_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab17_1_1_1_5" id="hd_h_ch6.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with stimulants + NSST</th><th headers="hd_h_ch6.tab17_1_1_1_5" id="hd_h_ch6.tab17_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + PT/FT versus stimulants + NSST (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, PT >3 months)</td><td headers="hd_h_ch6.tab17_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>69</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab17_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab17_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab17_1_1_1_5 hd_h_ch6.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, pt >3 months) in the control groups was</p>
|
||
<p>1</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_5 hd_h_ch6.tab17_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.20 higher</p>
|
||
<p>(0.08 lower to 0.48 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CTRS, 0-3, higher is worse, FV, FU >3 months)</td><td headers="hd_h_ch6.tab17_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>69</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab17_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab17_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab17_1_1_1_5 hd_h_ch6.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, fu >3 months) in the control groups was</p>
|
||
<p>0.8</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_5 hd_h_ch6.tab17_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ctrs, 0-3, higher is worse, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.10 higher</p>
|
||
<p>(0.11 lower to 0.31 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, PT >3 months)</td><td headers="hd_h_ch6.tab17_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>69</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab17_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab17_1_1_1_5 hd_h_ch6.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, pt >3 months) in the control groups was</p>
|
||
<p>0.9</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_5 hd_h_ch6.tab17_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0 higher</p>
|
||
<p>(0.36 lower to 0.36 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, CTRS, 0-3, higher is worse, FV, FU >3 months)</td><td headers="hd_h_ch6.tab17_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>69</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab17_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab17_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab17_1_1_1_5 hd_h_ch6.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, fu >3 months) in the control groups was</p>
|
||
<p>0.7</p>
|
||
</td><td headers="hd_h_ch6.tab17_1_1_1_5 hd_h_ch6.tab17_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ctrs, 0-3, higher is worse, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.30 higher</p>
|
||
<p>(0.03 to 0.57 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab17_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab17_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab18" class="table"><h3><span class="label">Table 18</span><span class="title">Clinical evidence summary: Stimulants + attention/memory/cognitive training compared to stimulants</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab18/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab18_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab18_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab18_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab18_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab18_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab18_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab18_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab18_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab18_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab18_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab18_1_1_1_5" id="hd_h_ch6.tab18_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Stimulants</th><th headers="hd_h_ch6.tab18_1_1_1_5" id="hd_h_ch6.tab18_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + attention/memory/cognitive training (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Conners 48, 0-70, high is poor, FV, <3 months PT)</td><td headers="hd_h_ch6.tab18_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>48</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab18_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab18_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab18_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab18_1_1_1_5 hd_h_ch6.tab18_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, conners 48, high is poor, fv, <3 months pt) in the control groups was</p>
|
||
<p>58.4</p>
|
||
</td><td headers="hd_h_ch6.tab18_1_1_1_5 hd_h_ch6.tab18_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, conners 48, high is poor, fv, <3 months pt) in the intervention groups was</p>
|
||
<p>8.67 lower</p>
|
||
<p>(11.5 to 5.84 lower)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab18_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab19" class="table"><h3><span class="label">Table 19</span><span class="title">Clinical evidence summary: Stimulants + NF versus stimulants</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab19/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab19_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab19_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab19_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab19_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab19_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab19_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab19_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab19_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab19_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab19_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab19_1_1_1_5" id="hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Stimulants</th><th headers="hd_h_ch6.tab19_1_1_1_5" id="hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + NF (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>28.1</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>3.50 lower</p>
|
||
<p>(7.57 lower to 0.57 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>0</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>23.5</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.80 lower</p>
|
||
<p>(5.67 lower to 4.07 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>23.7</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.60 lower</p>
|
||
<p>(8.51 lower to 3.31 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>26.1</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>4.00 lower</p>
|
||
<p>(9.55 lower to 1.55 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>12.2</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.70 lower</p>
|
||
<p>(5.14 to 0.26 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>11.4</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.50 lower</p>
|
||
<p>(3.27 lower to 2.27 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>11.2</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.50 lower</p>
|
||
<p>(6.37 lower to 1.37 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>13.1</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>1.50 lower</p>
|
||
<p>(5.64 lower to 2.64 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>6.4</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.60 higher</p>
|
||
<p>(0.83 lower to 2.03 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self-rated, SRQ, 1-10, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>5.9</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self-rated, srq, 1-10, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.00 higher</p>
|
||
<p>(1.22 lower to 1.22 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, srq, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>1.3</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, srq, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.30 lower</p>
|
||
<p>(1.87 lower to 1.27 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>15.9</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.80 lower</p>
|
||
<p>(3.05 lower to 1.45 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>12.1</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.30 lower</p>
|
||
<p>(2.94 lower to 0 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>12.5</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.10 lower</p>
|
||
<p>(3.16 lower to 2.96 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, Barkley’s, 0-54, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>13.1</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, barkley’s, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>1.50 lower</p>
|
||
<p>(4.48 lower to 1.48 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is poor, PT, <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, <3 months) in the control groups was</p>
|
||
<p>6.7</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, <3 months) in the intervention groups was</p>
|
||
<p>0.40 lower</p>
|
||
<p>(1.62 lower to 0.82 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self-rated, SRQ, 1-10, high is poor, FU, >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, >3 months) in the control groups was</p>
|
||
<p>6</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self-rated, srq, 1-10, high is poor, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.90 higher</p>
|
||
<p>(0.18 lower to 1.98 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>52</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, srq, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>1.4</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, srq, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.20 lower</p>
|
||
<p>(1.58 lower to 1.18 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, CS, PT <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>49</p>
|
||
<p>(1 study)</p>
|
||
<p><3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, cs, pt <3 months) in the control groups was</p>
|
||
<p>0.1</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>1.10 lower</p>
|
||
<p>(2.84 lower to 0.64 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, PT <3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>61</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt <3 months) in the control groups was</p>
|
||
<p>6.4</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt <3 months) in the intervention groups was</p>
|
||
<p>0.60 higher</p>
|
||
<p>(0.83 lower to 2.03 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic (general, self, SRQ, 1-10, high is good, FU >3 months)</td><td headers="hd_h_ch6.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab19_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab19_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt >3 months) in the control groups was</p>
|
||
<p>5.9</p>
|
||
</td><td headers="hd_h_ch6.tab19_1_1_1_5 hd_h_ch6.tab19_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic (general, self, 1-10, high is good, pt >3 months) in the intervention groups was</p>
|
||
<p>0.00 higher</p>
|
||
<p>(1.22 lower to 1.22 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab19_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab19_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab19_3"><p class="no_margin">Downgraded by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab20" class="table"><h3><span class="label">Table 20</span><span class="title">Clinical evidence summary: Mixed medication + PT/FT versus mixed medication</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab20/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab20_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab20_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab20_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab20_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab20_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab20_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab20_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab20_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab20_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab20_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab20_1_1_1_5" id="hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Mixed medication</th><th headers="hd_h_ch6.tab20_1_1_1_5" id="hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Mixed medication + PT/FT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>270</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, 0-54, high is poor, cs, fu, >3 months) in the intervention groups was</p>
|
||
<p>0.27 standard deviations lower</p>
|
||
<p>(0.51 to 0.03 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>242</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher and parent, snap, high is poor, fv, fu >3 months) in the control groups was</p>
|
||
<p>1.21</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher and parent, snap, high is poor, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.01 lower</p>
|
||
<p>(0.15 lower to 0.13 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, Conner’s, 0-20, high is poor, FV, PT, <3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>54</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, conner’s, high is poor, fv, pt, <3 months) in the control groups was</p>
|
||
<p>13.93</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, conner’s, high is poor, fv, pt, <3 months) in the intervention groups was</p>
|
||
<p>2.22 higher</p>
|
||
<p>(4.38 lower to 8.82 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, multiple scales, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>309</p>
|
||
<p>(2 studies)</p>
|
||
<p>3-14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, multiple scales, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>3.13</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, multiple scales, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.05 standard deviations lower</p>
|
||
<p>(0.28 lower to 0.17 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>254</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>0.91</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.94 higher</p>
|
||
<p>(0.78 to 1.1 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>224</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>0.16</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.05 higher</p>
|
||
<p>(0 to 0.1 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>270</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, 0-54, high is poor, cs, fu, >3 months) in the intervention groups was</p>
|
||
<p>0.22 standard deviations lower</p>
|
||
<p>(0.46 lower to 0.02 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>254</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.12</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.10 lower</p>
|
||
<p>(0.27 lower to 0.07 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>254</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.11</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.01 higher</p>
|
||
<p>(0.18 lower to 0.2 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS-IV, 0-54, high is poor, CS, FU, >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>270</p>
|
||
<p>(1 study)</p>
|
||
<p>12 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, 0-54, high is poor, cs, fu, >3 months) in the intervention groups was</p>
|
||
<p>0.27 standard deviations lower</p>
|
||
<p>(0.51 to 0.03 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (CBRS aggressive behaviour subscale, 0-15, high is poor, teacher, PT <3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (cbrs aggressive behaviour subscale, high is poor, teacher, pt <3 months) in the control groups was</p>
|
||
<p>11.58</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (cbrs aggressive behaviour subscale, high is poor, teacher, pt <3 months) in the intervention groups was</p>
|
||
<p>1.58 lower</p>
|
||
<p>(8.11 lower to 4.95 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (CBRS aggressive behaviour subscale, 0-15, high is poor, teacher, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>55</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (cbrs aggressive behaviour subscale, high is poor, teacher, pt >3 months) in the control groups was</p>
|
||
<p>12.78</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (cbrs aggressive behaviour subscale, high is poor, teacher, pt >3 months) in the intervention groups was</p>
|
||
<p>2.28 lower</p>
|
||
<p>(8.8 lower to 4.24 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (CBRS emotional distress subscale, 0-20, high is poor, teacher, PT <3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (cbrs emotional distress subscale, high is poor, teacher, pt <3 months) in the control groups was</p>
|
||
<p>13.04</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (cbrs emotional distress subscale, high is poor, teacher, pt <3 months) in the intervention groups was</p>
|
||
<p>4.22 higher</p>
|
||
<p>(2.14 lower to 10.58 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (CBRS emotional distress subscale, 0-20, high is poor, teacher, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>55</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (cbrs emotional distress subscale, high is poor, teacher, pt >3 months) in the control groups was</p>
|
||
<p>14.44</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (cbrs emotional distress subscale, high is poor, teacher, pt >3 months) in the intervention groups was</p>
|
||
<p>2.35 higher</p>
|
||
<p>(4.16 lower to 8.86 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy %, observer, high is better, pt <3 months) in the control groups was</p>
|
||
<p>87.75</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy %, observer, high is better, pt <3 months) in the intervention groups was</p>
|
||
<p>3.15 higher</p>
|
||
<p>(0.15 to 6.15 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>260</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the control groups was</p>
|
||
<p>99.7</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the intervention groups was</p>
|
||
<p>0.80 higher</p>
|
||
<p>(2.78 lower to 4.38 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy %, observer, high is better, pt <3 months) in the control groups was</p>
|
||
<p>86.14</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy %, observer, high is better, pt <3 months) in the intervention groups was</p>
|
||
<p>4.28 higher</p>
|
||
<p>(0.3 to 8.26 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>260</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the control groups was</p>
|
||
<p>97.9</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the intervention groups was</p>
|
||
<p>1.50 higher</p>
|
||
<p>(2.06 lower to 5.06 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>242</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab20_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, fu >3 months) in the control groups was</p>
|
||
<p>97.8</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, fu >3 months) in the intervention groups was</p>
|
||
<p>0.10 lower</p>
|
||
<p>(3.53 lower to 3.33 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (general, CBRS academic subscale, 0-30, high is poor, teacher, PT <3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>50</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (general, cbrs academic subscale, high is poor, teacher, pt <3 months) in the control groups was</p>
|
||
<p>17.88</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (general, cbrs academic subscale, high is poor, teacher, pt <3 months) in the intervention groups was</p>
|
||
<p>2.25 higher</p>
|
||
<p>(4.95 lower to 9.45 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (general, CBRS academic subscale, 0-30, high is poor, teacher, PT >3 months)</td><td headers="hd_h_ch6.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab20_3">c</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab20_4">d</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (general, cbrs academic subscale, high is poor, teacher, pt >3 months) in the control groups was</p>
|
||
<p>21.52</p>
|
||
</td><td headers="hd_h_ch6.tab20_1_1_1_5 hd_h_ch6.tab20_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (general, cbrs academic subscale, high is poor, teacher, pt >3 months) in the intervention groups was</p>
|
||
<p>0.48 lower</p>
|
||
<p>(7.09 lower to 6.13 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab20_1"><p class="no_margin">Control group not available.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab20_2"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab20_3"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd><dt>(d)</dt><dd><div id="ch6.tab20_4"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab21" class="table"><h3><span class="label">Table 21</span><span class="title">Clinical evidence summary: Mixed medication + CBT versus mixed medication</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab21/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab21_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab21_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab21_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab21_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab21_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab21_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab21_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab21_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab21_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab21_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab21_1_1_1_5" id="hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Mixed medication</th><th headers="hd_h_ch6.tab21_1_1_1_5" id="hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Mixed medication + CBT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</td><td headers="hd_h_ch6.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>92</p>
|
||
<p>(1 study)</p>
|
||
<p>4 months</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab21_5">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, ADHD-rs, 0-54, high is poor, cs, pt >3 months) in the intervention groups was</p>
|
||
<p>1.08 standard deviations lower</p>
|
||
<p>(1.52 to 0.64 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>119</p>
|
||
<p>(1 study)</p>
|
||
<p>12 sessions</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab21_6">c</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>26.09</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>7.62 lower</p>
|
||
<p>(7.98 to 7.26 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>119</p>
|
||
<p>(1 study)</p>
|
||
<p>12 sessions</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab21_6">c</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>28.44</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>9.39 lower</p>
|
||
<p>(9.79 to 8.99 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</td><td headers="hd_h_ch6.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>92</p>
|
||
<p>(1 study)</p>
|
||
<p>4 months</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab21_5">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, 0-54, high is poor, cs, pt >3 months) in the intervention groups was</p>
|
||
<p>2.21 standard deviations lower</p>
|
||
<p>(2.74 to 1.69 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>119</p>
|
||
<p>(1 study)</p>
|
||
<p>12 sessions</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab21_6">c</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>11.72</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>3.43 lower</p>
|
||
<p>(3.74 to 3.12 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>119</p>
|
||
<p>(1 study)</p>
|
||
<p>12 sessions</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab21_6">c</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>11.56</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>3.84 lower</p>
|
||
<p>(4.12 to 3.56 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>119</p>
|
||
<p>(1 study)</p>
|
||
<p>12 sessions</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab21_6">c</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>14.47</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>4.33 lower</p>
|
||
<p>(4.51 to 4.15 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>119</p>
|
||
<p>(1 study)</p>
|
||
<p>12 sessions</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab21_6">c</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>16.99</p>
|
||
</td><td headers="hd_h_ch6.tab21_1_1_1_5 hd_h_ch6.tab21_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, ADHD-rs, 0-54, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>5.68 lower</p>
|
||
<p>(5.89 to 5.47 lower)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.tab21_1"><p class="no_margin">Control group not available.</p></div></dd><dt>2</dt><dd><div id="ch6.tab21_2"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>3</dt><dd><div id="ch6.tab21_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab21_4"><p class="no_margin">Control group not available.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab21_5"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab21_6"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab22" class="table"><h3><span class="label">Table 22</span><span class="title">Clinical evidence summary: Mixed medication + PE versus mixed medication + NSST</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab22/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab22_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab22_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab22_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab22_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab22_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab22_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab22_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab22_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab22_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab22_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab22_1_1_1_5" id="hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Mixed medication + NSST</th><th headers="hd_h_ch6.tab22_1_1_1_5" id="hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Mixed medication + PE (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CPRS, 0-27, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>78</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab22_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab22_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, cprs, 0-27, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>8.45</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, cprs, 0-27, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>1.71 lower</p>
|
||
<p>(3.67 lower to 0.25 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, CPRS, 0-27, high is poor, FV, FU >3 months)</td><td headers="hd_h_ch6.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>76</p>
|
||
<p>(1 study)</p>
|
||
<p>64 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab22_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab22_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, cprs, 0-27, high is poor, fv, fu >3 months) in the control groups was</p>
|
||
<p>8.47</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, cprs, 0-27, high is poor, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>1.07 lower</p>
|
||
<p>(3.02 lower to 0.88 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, CPRS, 0-27, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>78</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab22_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab22_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, cprs, 0-27, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>11</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, cprs, 0-27, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>3.05 lower</p>
|
||
<p>(4.63 to 1.47 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, CPRS, 0-27, high is poor, FV, FU >3 months)</td><td headers="hd_h_ch6.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>76</p>
|
||
<p>(1 study)</p>
|
||
<p>64 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab22_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab22_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, cprs, 0-27, high is poor, fv, fu >3 months) in the control groups was</p>
|
||
<p>10.41</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, cprs, 0-27, high is poor, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>2.15 lower</p>
|
||
<p>(3.93 to 0.37 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (opposition, parent, CPRS, 0-27, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>78</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab22_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab22_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (opposition, parent, cprs, 0-27, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>6.18</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (opposition, parent, cprs, 0-27, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>1.23 lower</p>
|
||
<p>(2.94 lower to 0.48 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (opposition, parent, CPRS, 0-27, high is poor, FV, FU >3 months)</td><td headers="hd_h_ch6.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>76</p>
|
||
<p>(1 study)</p>
|
||
<p>64 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab22_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab22_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (opposition, parent, cprs, 0-27, high is poor, fv, fu >3 months) in the control groups was</p>
|
||
<p>5.63</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (opposition, parent, cprs, 0-27, high is poor, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.43 lower</p>
|
||
<p>(2.21 lower to 1.35 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (SDQ, parent, 0-25, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>76</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab22_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (sdq, parent, 0-25, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>3.5</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (sdq, parent, 0-25, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.11 lower</p>
|
||
<p>(1.21 lower to 0.99 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (SDQ, parent, 0-25, high is poor, FV, FU >3 months)</td><td headers="hd_h_ch6.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>76</p>
|
||
<p>(1 study)</p>
|
||
<p>64 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab22_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab22_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (sdq, parent, 0-25, high is poor, fv, fu >3 months) in the control groups was</p>
|
||
<p>3.75</p>
|
||
</td><td headers="hd_h_ch6.tab22_1_1_1_5 hd_h_ch6.tab22_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (sdq, parent, 0-25, high is poor, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.29 lower</p>
|
||
<p>(1.32 lower to 0.74 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab22_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab22_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab23" class="table"><h3><span class="label">Table 23</span><span class="title">Clinical evidence summary: Mixed medication + sleep intervention versus mixed medication</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab23/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab23_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab23_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab23_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab23_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab23_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab23_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab23_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab23_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab23_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab23_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab23_1_1_1_5" id="hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Mixed medication</th><th headers="hd_h_ch6.tab23_1_1_1_5" id="hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Mixed medication + sleep intervention (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, ADHD-rs, 0-54, high is poor, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.21 standard deviations lower</p>
|
||
<p>(0.46 lower to 0.04 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab23_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, 0-54, high is poor, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.39 standard deviations lower</p>
|
||
<p>(0.64 to 0.13 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, ADHD-rs, 0-54, high is poor, cs, pt >3 months) in the intervention groups was</p>
|
||
<p>0.18 standard deviations lower</p>
|
||
<p>(0.43 lower to 0.07 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab23_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, 0-54, high is poor, cs, pt >3 months) in the intervention groups was</p>
|
||
<p>0.41 standard deviations lower</p>
|
||
<p>(0.66 to 0.15 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab23_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ADHD-rs, 0-54, high is poor, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.28 standard deviations lower</p>
|
||
<p>(0.53 to 0.03 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab23_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ADHD-rs, 0-54, high is poor, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.27 standard deviations lower</p>
|
||
<p>(0.52 to 0.02 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>6 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, ADHD-rs, 0-54, high is poor, cs, pt >3 months) in the intervention groups was</p>
|
||
<p>0.18 standard deviations lower</p>
|
||
<p>(0.44 lower to 0.07 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab23_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, ADHD-rs, 0-54, high is poor, cs, pt >3 months) in the intervention groups was</p>
|
||
<p>0.29 standard deviations lower</p>
|
||
<p>(0.54 to 0.04 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, ADHD-rs, 0-54, high is poor, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.11 standard deviations lower</p>
|
||
<p>(0.36 lower to 0.14 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, CS, PT <3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab23_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, ADHD-rs, 0-54, high is poor, cs, pt <3 months) in the intervention groups was</p>
|
||
<p>0.43 standard deviations lower</p>
|
||
<p>(0.68 to 0.18 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, ADHD-rs, 0-54, high is poor, cs, pt >3 months) in the intervention groups was</p>
|
||
<p>0.11 standard deviations lower</p>
|
||
<p>(0.36 lower to 0.14 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, ADHD-RS, 0-54, high is poor, CS, PT >3 months)</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab23_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, ADHD-rs, 0-54, high is poor, cs, pt >3 months) in the intervention groups was</p>
|
||
<p>0.46 standard deviations lower</p>
|
||
<p>(0.72 to 0.21 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (teacher, SDQ, 0-54, high is poor, CS, <3 months PT</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>3 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (teacher, sdq, 0-54, high is poor, cs, <3 months pt in the intervention groups was</p>
|
||
<p>0.25 standard deviations lower</p>
|
||
<p>(0.5 lower to 0 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (teacher, SDQ, 0-54, high is poor, CS, >3 months PT</td><td headers="hd_h_ch6.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>244</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab23_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab23_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 Control group results unavailable</td><td headers="hd_h_ch6.tab23_1_1_1_5 hd_h_ch6.tab23_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (teacher, sdq, 0-54, high is poor, cs, >3 months pt in the intervention groups was</p>
|
||
<p>0.32 standard deviations lower</p>
|
||
<p>(0.57 to 0.06 lower)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab23_1"><p class="no_margin">No control group data available.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab23_2"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab23_3"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab24" class="table"><h3><span class="label">Table 24</span><span class="title">Clinical evidence summary: Mixed medication + NF compared to mixed medication</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab24/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab24_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab24_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab24_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab24_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab24_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab24_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab24_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab24_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab24_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab24_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab24_1_1_1_5" id="hd_h_ch6.tab24_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Mixed medication</th><th headers="hd_h_ch6.tab24_1_1_1_5" id="hd_h_ch6.tab24_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Mixed medication + NF (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, ADHD-RS, 0-54, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab24_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>36</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab24_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab24_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab24_1_1_1_5 hd_h_ch6.tab24_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, 0-54, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>15.22</p>
|
||
</td><td headers="hd_h_ch6.tab24_1_1_1_5 hd_h_ch6.tab24_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, ADHD-rs, 0-54, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>4.44 lower</p>
|
||
<p>(7.07 to 1.81 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (CBRS, parent, unclear scale, high is poor, FV, PT <3 months)</td><td headers="hd_h_ch6.tab24_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>36</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab24_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab24_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab24_1_1_1_5 hd_h_ch6.tab24_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (cbrs, parent, unclear scale, high is poor, fv, pt <3 months) in the control groups was</p>
|
||
<p>11.33</p>
|
||
</td><td headers="hd_h_ch6.tab24_1_1_1_5 hd_h_ch6.tab24_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (cbrs, parent, unclear scale, high is poor, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>3.72 lower</p>
|
||
<p>(6.96 to 0.48 lower)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab24_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab24_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab25" class="table"><h3><span class="label">Table 25</span><span class="title">Clinical evidence summary: Atomoxetine + PT/FT versus placebo/usual care</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab25/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab25_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab25_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab25_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab25_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab25_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab25_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab25_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab25_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab25_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab25_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab25_1_1_1_5" id="hd_h_ch6.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Placebo/usual care</th><th headers="hd_h_ch6.tab25_1_1_1_5" id="hd_h_ch6.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Atomoxetine + PT/FT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab25_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.74</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.51 lower</p>
|
||
<p>(0.89 to 0.13 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab25_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.44</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.30 lower</p>
|
||
<p>(0.71 lower to 0.11 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab25_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.69</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.54 lower</p>
|
||
<p>(0.96 to 0.12 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab25_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.25</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.27 lower</p>
|
||
<p>(0.72 lower to 0.18 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab25_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.79</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.49 lower</p>
|
||
<p>(0.87 to 0.11 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, higher is worse, FV, PT <3 months)</td><td headers="hd_h_ch6.tab25_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the control groups was</p>
|
||
<p>1.63</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, 0-3, higher is worse, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.33 lower</p>
|
||
<p>(0.78 lower to 0.12 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab25_1_1_1_1" rowspan="2" colspan="1" style="vertical-align:top;">Responders by CGI-I (PT, <3 months)</td><td headers="hd_h_ch6.tab25_1_1_1_2" rowspan="2" colspan="1" style="vertical-align:top;">
|
||
<p>62</p>
|
||
<p>(1 study)</p>
|
||
<p>10 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_3" rowspan="2" colspan="1" style="vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab24_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab24_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_4" rowspan="2" colspan="1" style="vertical-align:top;">
|
||
<p>RR 2.5</p>
|
||
<p>(1.12 to 5.59)</p>
|
||
</td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_1 hd_h_ch6.tab25_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">194 per 1000</td><td headers="hd_h_ch6.tab25_1_1_1_5 hd_h_ch6.tab25_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>291 more per 1000</p>
|
||
<p>(from 23 more to 890 more)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch6.tab25_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>2</dt><dd><div id="ch6.tab25_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID.</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab25_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab25_4"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab26" class="table"><h3><span class="label">Table 26</span><span class="title">Clinical evidence summary: Mixed medication + PT/FT versus placebo/usual care</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab26/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab26_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab26_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab26_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab26_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab26_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab26_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab26_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab26_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab26_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab26_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab26_1_1_1_5" id="hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Placebo/usual care</th><th headers="hd_h_ch6.tab26_1_1_1_5" id="hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Mixed medication + PT/FT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher and parent, SNAP, 0-3, high is poor, FV, FU >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>243</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher and parent, snap, high is poor, fv, fu >3 months) in the control groups was</p>
|
||
<p>1.26</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher and parent, snap, high is poor, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>0.06 lower</p>
|
||
<p>(0.2 lower to 0.08 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, SNAP, 0-3, high is poor, FV, PT, >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>262</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab26_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, high is poor, fv, pt, >3 months) in the control groups was</p>
|
||
<p>1.25</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, snap, high is poor, fv, pt, >3 months) in the intervention groups was</p>
|
||
<p>0.50 lower</p>
|
||
<p>(0.69 to 0.31 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>263</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab26_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.35</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.50 higher</p>
|
||
<p>(0.34 to 0.66 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>223</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>0.18</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.03 higher</p>
|
||
<p>(0.02 lower to 0.08 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>263</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab26_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.49</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.47 lower</p>
|
||
<p>(0.63 to 0.31 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, SNAP, 0-3, high is poor, FV, PT >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>262</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab26_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, high is poor, fv, pt >3 months) in the control groups was</p>
|
||
<p>1.48</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, snap, high is poor, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>0.36 lower</p>
|
||
<p>(0.55 to 0.17 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy %, observer, high is better, PT <3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab26_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab26_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy%, observer, high is better, pt <3 months) in the control groups was</p>
|
||
<p>83.85</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy%, observer, high is better, pt <3 months) in the intervention groups was</p>
|
||
<p>7.05 higher</p>
|
||
<p>(3.69 to 10.41 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>267</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the control groups was</p>
|
||
<p>100.4</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (maths accuracy, observer, WIAT, 0-132, high is better, pt >3 months) in the intervention groups was</p>
|
||
<p>0.10 higher</p>
|
||
<p>(3.69 lower to 3.89 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy %, observer, high is better, PT <3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>75</p>
|
||
<p>(1 study)</p>
|
||
<p>8 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab26_2">b</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab26_3">c</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, %, observer, high is better, pt <3 months) in the control groups was</p>
|
||
<p>82.76</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, %, observer, high is better, pt <3 months) in the intervention groups was</p>
|
||
<p>7.66 higher</p>
|
||
<p>(3.35 to 11.97 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, PT >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>267</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab26_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy,, observer, WIAT, 0-132, high is better, pt >3 months) in the control groups was</p>
|
||
<p>95.4</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy,, observer, WIAT, 0-132, high is better, pt >3 months) in the intervention groups was</p>
|
||
<p>4.00 higher</p>
|
||
<p>(0.47 to 7.53 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, FU >3 months)</td><td headers="hd_h_ch6.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>243</p>
|
||
<p>(1 study)</p>
|
||
<p>14 months</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab26_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy, observer, WIAT, 0-132, high is better, fu >3 months) in the control groups was</p>
|
||
<p>96</p>
|
||
</td><td headers="hd_h_ch6.tab26_1_1_1_5 hd_h_ch6.tab26_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean academic outcomes (reading accuracy,, observer, WIAT, 0-132, high is better, fu >3 months) in the intervention groups was</p>
|
||
<p>1.70 higher</p>
|
||
<p>(1.87 lower to 5.27 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab26_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab26_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1MID.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab26_3"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab27" class="table"><h3><span class="label">Table 27</span><span class="title">Clinical evidence summary: Stimulants + NF versus stimulants + attention/memory/cognitive training</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab27/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab27_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab27_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab27_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab27_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab27_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab27_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab27_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab27_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab27_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab27_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab27_1_1_1_5" id="hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Stimulants + attention/memory/cognitive training</th><th headers="hd_h_ch6.tab27_1_1_1_5" id="hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + NF (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>8-20 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the control groups was</p>
|
||
<p>41.2</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>2.60 lower</p>
|
||
<p>(6.97 lower to 1.77 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>8-20 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the control groups was</p>
|
||
<p>41.8</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>3.90 lower</p>
|
||
<p>(8.79 lower to 0.99 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the control groups was</p>
|
||
<p>44.9</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, parent, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>7.00 lower</p>
|
||
<p>(10.85 to 3.15 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the control groups was</p>
|
||
<p>43.7</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, teacher, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>8.70 lower</p>
|
||
<p>(13.12 to 4.28 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>8-20 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the control groups was</p>
|
||
<p>17.3</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>0.70 lower</p>
|
||
<p>(3.42 lower to 2.02 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>8-20 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the control groups was</p>
|
||
<p>18.4</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>1.60 lower</p>
|
||
<p>(4.57 lower to 1.37 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the control groups was</p>
|
||
<p>19.2</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, parent, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>3.20 lower</p>
|
||
<p>(5.83 to 0.57 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the control groups was</p>
|
||
<p>19.8</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, teacher, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>3.70 lower</p>
|
||
<p>(6.89 to 0.51 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>8-20 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the control groups was</p>
|
||
<p>23.9</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>1.30 lower</p>
|
||
<p>(3.83 lower to 1.23 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, DSM-IV, high is poor, unclear scale, FV, PT <3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>64</p>
|
||
<p>(1 study)</p>
|
||
<p>8-20 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the control groups was</p>
|
||
<p>23.6</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, dsm-iv, high is poor, unclear scale, fv, pt <3 months) in the intervention groups was</p>
|
||
<p>2.40 lower</p>
|
||
<p>(5.1 lower to 0.3 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, parent, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>6 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab27_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the control groups was</p>
|
||
<p>25.7</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, parent, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>4.10 lower</p>
|
||
<p>(6.43 to 1.77 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, teacher, DSM-IV, high is poor, unclear scale, FV, FU >3 months)</td><td headers="hd_h_ch6.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60</p>
|
||
<p>(1 study)</p>
|
||
<p>6 months</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HIGH</td><td headers="hd_h_ch6.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the control groups was</p>
|
||
<p>25.4</p>
|
||
</td><td headers="hd_h_ch6.tab27_1_1_1_5 hd_h_ch6.tab27_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, teacher, dsm-iv, high is poor, unclear scale, fv, fu >3 months) in the intervention groups was</p>
|
||
<p>5.50 lower</p>
|
||
<p>(7.4 to 3.6 lower)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab27_1"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab28" class="table"><h3><span class="label">Table 28</span><span class="title">Clinical evidence summary: stimulants + NSST versus CBT</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab28/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab28_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab28_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab28_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab28_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab28_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab28_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab28_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab28_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab28_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab28_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab28_1_1_1_5" id="hd_h_ch6.tab28_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with CBT</th><th headers="hd_h_ch6.tab28_1_1_1_5" id="hd_h_ch6.tab28_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + NSST (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab28_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>213</p>
|
||
<p>(1 study)</p>
|
||
<p>1 years</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab28_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab28_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, caars, high is worse, fv, >3 months pt) in the CBT groups was</p>
|
||
<p>16.9</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>1.80 lower</p>
|
||
<p>(3.63 lower to 0.03 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab28_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>210</p>
|
||
<p>(1 study)</p>
|
||
<p>1 years</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab28_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab28_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, caars, high is worse, fv, >3 months pt) in the CBT groups was</p>
|
||
<p>16.4</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>1.80 lower</p>
|
||
<p>(3.49 to 0.11 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab28_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>210</p>
|
||
<p>(1 study)</p>
|
||
<p>1 years</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab28_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab28_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, high is worse, fv, >3 months pt) in the CBT groups was</p>
|
||
<p>14.9</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>1.60 lower</p>
|
||
<p>(3.41 lower to 0.21 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab28_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>213</p>
|
||
<p>(1 study)</p>
|
||
<p>1 years</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab28_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, high is worse, fv, >3 months pt) in the CBT groups was</p>
|
||
<p>15.2</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.80 higher</p>
|
||
<p>(0.95 lower to 2.55 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab28_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>210</p>
|
||
<p>(1 study)</p>
|
||
<p>1 years</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab28_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-63, high is poor, fv, >3 months pt) in the CBT groups was</p>
|
||
<p>9.4</p>
|
||
</td><td headers="hd_h_ch6.tab28_1_1_1_5 hd_h_ch6.tab28_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-63, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.20 higher</p>
|
||
<p>(1.77 lower to 2.17 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab28_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab28_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab29" class="table"><h3><span class="label">Table 29</span><span class="title">Clinical evidence summary: stimulants + CBT/DBT versus CBT/DBT alone</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab29/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab29_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab29_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab29_1_1_1_1" style="text-align:left;vertical-align:top;">Outcomes</th><th id="hd_h_ch6.tab29_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab29_1_1_1_2" style="text-align:left;vertical-align:top;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab29_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab29_1_1_1_3" style="text-align:left;vertical-align:top;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab29_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab29_1_1_1_4" style="text-align:left;vertical-align:top;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab29_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab29_1_1_1_5" id="hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk with CBT/DBT alone</th><th headers="hd_h_ch6.tab29_1_1_1_5" id="hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk difference with Stimulants + CBT/DBT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>209</p>
|
||
<p>(1 study)</p>
|
||
<p>1 years</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab29_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab29_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>16.9</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>1.60 lower</p>
|
||
<p>(2.50 to 0.70 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, multiple tools, decreased by >30%, >3 months PT) - General population</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>106</p>
|
||
<p>(1 study)</p>
|
||
<p>14 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab29_2">b</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 0.86</p>
|
||
<p>(0.59 to 1.26)</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1 hd_h_ch6.tab29_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">547 per 1000</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>77 fewer per 1000</p>
|
||
<p>(from 224 fewer to 142 more)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, multiple tools, decreased by >30%, >3 months PT) - Secure estate</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>24 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab29_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab29_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 2.34</p>
|
||
<p>(1.17 to 4.69)</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1 hd_h_ch6.tab29_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">269 per 1000</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>360 more per 1000</p>
|
||
<p>(from 46 more to 993 more)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, TAADDS, decreased by >30%, >3 months PT)</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>106</p>
|
||
<p>(1 study)</p>
|
||
<p>14 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab29_1">a</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 1.4</p>
|
||
<p>(0.81 to 2.41)</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1 hd_h_ch6.tab29_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">283 per 1000</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>113 more per 1000</p>
|
||
<p>(from 54 fewer to 399 more)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, multiple tools, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>257</p>
|
||
<p>(2 studies)</p>
|
||
<p>20-52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab29_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab29_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Control group results unavailable</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, multiple tools, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.43 standard deviations lower</p>
|
||
<p>(0.67 to 0.18 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>209</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab29_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab29_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>14.9</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>1.90 lower</p>
|
||
<p>(2.84 to 0.96 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>209</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab29_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab29_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>16</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>1.00 lower</p>
|
||
<p>(1.92 to 0.08 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (multiple tools, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>257</p>
|
||
<p>(2 studies)</p>
|
||
<p>20-52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab29_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Control group results unavailable</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (multiple tools, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.06 standard deviations lower</p>
|
||
<p>(0.3 lower to 0.19 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (>3 months PT)</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>106</p>
|
||
<p>(1 study)</p>
|
||
<p>14 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab29_2">b</a></sup></p>
|
||
<p>due to imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 1.12</p>
|
||
<p>(0.65 to 1.96)</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1 hd_h_ch6.tab29_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">302 per 1000</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>36 more per 1000</p>
|
||
<p>(from 106 fewer to 290 more)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Responders by CGI-I (>3 months FU)</td><td headers="hd_h_ch6.tab29_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>48</p>
|
||
<p>(1 study)</p>
|
||
<p>20 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">HIGH</td><td headers="hd_h_ch6.tab29_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 4.08</p>
|
||
<p>(1.58 to 10.5)</p>
|
||
</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1 hd_h_ch6.tab29_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">160 per 1000</td><td headers="hd_h_ch6.tab29_1_1_1_5 hd_h_ch6.tab29_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>493 more per 1000</p>
|
||
<p>(from 93 more to 1000 more)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab29_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab29_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab30" class="table"><h3><span class="label">Table 30</span><span class="title">Clinical evidence summary: stimulants + CBT/DBT + PT/FT versus NSST + PT/FT alone</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab30/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab30_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab30_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab30_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab30_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab30_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab30_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab30_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab30_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab30_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab30_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab30_1_1_1_5" id="hd_h_ch6.tab30_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with NSST + PT/FT</th><th headers="hd_h_ch6.tab30_1_1_1_5" id="hd_h_ch6.tab30_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + CBT/DBT + PT/FT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, CAARS, 0-36, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab30_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>143</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab30_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab30_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, caars, 0-36, high is poor, fv, >3 months pt) in the control groups was</p>
|
||
<p>15.8</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, caars, 0-36, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>2.70 lower</p>
|
||
<p>(4.58 to 0.82 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-36, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab30_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>143</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab30_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab30_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, 0-36, high is poor, fv, >3 months pt) in the control groups was</p>
|
||
<p>13.7</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, 0-36, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>3.00 lower</p>
|
||
<p>(4.88 to 1.12 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-36, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab30_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>143</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab30_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab30_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, 0-36, high is poor, fv, >3 months pt) in the control groups was</p>
|
||
<p>15.1</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, 0-36, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>2.70 lower</p>
|
||
<p>(4.79 to 0.61 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Child’s ADHD symptoms (total, parent, SDQ, 0-10, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab30_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>144</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab30_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab30_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean child’s ADHD symptoms (total, parent, sdq, 0-10, high is poor, fv, >3 months pt) in the control groups was</p>
|
||
<p>6.2</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean child’s ADHD symptoms (total, parent, sdq, 010, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.50 lower</p>
|
||
<p>(1.13 lower to 0.13 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (parent, SDQ, 0-10, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab30_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>144</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab30_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (parent, sdq, 0-10, high is poor, fv, >3 months pt) in the control groups was</p>
|
||
<p>3.1</p>
|
||
</td><td headers="hd_h_ch6.tab30_1_1_1_5 hd_h_ch6.tab30_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (parent, sdq, 0-10, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.20 higher</p>
|
||
<p>(0.43 lower to 0.83 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab30_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab30_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab31" class="table"><h3><span class="label">Table 31</span><span class="title">Clinical evidence summary: stimulants + CBT/DBT versus stimulants + NSST alone</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab31/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab31_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab31_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab31_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab31_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab31_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab31_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab31_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab31_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab31_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab31_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab31_1_1_1_5" id="hd_h_ch6.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Stimulants + NSST</th><th headers="hd_h_ch6.tab31_1_1_1_5" id="hd_h_ch6.tab31_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + CBT/DBT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab31_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>213</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab31_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>15.1</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.20 higher</p>
|
||
<p>(1.55 lower to 1.95 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab31_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>213</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab31_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>14.6</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.30 higher</p>
|
||
<p>(1.45 lower to 2.05 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab31_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>209</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab31_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>13.3</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.30 lower</p>
|
||
<p>(1.98 lower to 1.38 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab31_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>209</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab31_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>15.2</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.20 lower</p>
|
||
<p>(1.88 lower to 1.48 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab31_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>213</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab31_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-63, high is poor, fv, >3 months pt) in the control groups was</p>
|
||
<p>9.6</p>
|
||
</td><td headers="hd_h_ch6.tab31_1_1_1_5 hd_h_ch6.tab31_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-63, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>0.70 lower</p>
|
||
<p>(2.66 lower to 1.26 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab31_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab32" class="table"><h3><span class="label">Table 32</span><span class="title">Clinical evidence summary: mixed medication + CBT/DBT versus mixed medication alone</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab32/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab32_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab32_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab32_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab32_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab32_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab32_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab32_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab32_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab32_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab32_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab32_1_1_1_5" id="hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with mixed medication alone</th><th headers="hd_h_ch6.tab32_1_1_1_5" id="hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with mixed medication + CBT/DBT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">QoL (Flanagan, 16-112, high is good, FV, <3 months PT)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>69</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean qol (flanagan, 16-112, high is good, fv, <3 months pt) in the control groups was</p>
|
||
<p>70.9</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean qol (flanagan, 16-112, high is good, fv, <3 months pt) in the intervention groups was</p>
|
||
<p>3.60 higher</p>
|
||
<p>(3.68 lower to 10.88 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">QoL (Flanagan, 16-112, high is good, FV, <3 months FU)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean qol (flanagan, 16-112, high is good, fv, <3 months fu) in the control groups was</p>
|
||
<p>72.22</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean qol (flanagan, 16-112, high is good, fv, <3 months fu) in the intervention groups was</p>
|
||
<p>7.62 higher</p>
|
||
<p>(1.03 to 14.21 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, ADHD-RS, 0-54, higher is worse, FV, PT >3 months)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>31</p>
|
||
<p>(1 study)</p>
|
||
<p>15 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, ADHD-rs, 0-54, higher is worse, fv, pt >3 months) in the control groups was</p>
|
||
<p>20.8</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, ADHD-rs, 0-54, higher is worse, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>5.61 lower</p>
|
||
<p>(12.11 lower to 0.89 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, 0-54, higher is worse, FV, PT >3 months)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>31</p>
|
||
<p>(1 study)</p>
|
||
<p>15 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, ADHD-rs, 0-54, higher is worse, fv, pt >3 months) in the control groups was</p>
|
||
<p>23.87</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, ADHD-rs, 0-54, higher is worse, fv, pt >3 months) in the intervention groups was</p>
|
||
<p>9.12 lower</p>
|
||
<p>(15.69 to 2.55 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, Barkley, 0-54, high is poor, FV, <3 months PT)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>104</p>
|
||
<p>(2 studies)</p>
|
||
<p>8-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The mean ADHD symptoms (total, self, barkley, 0-54, high is poor, fv, <3 months pt) in the control groups was 21.57</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, barkley, 0-54, high is poor, fv, <3 months pt) in the intervention groups was</p>
|
||
<p>5.01 lower (8.30 to 1.72 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, Barkley, 0-54, high is poor, FV, <3 months FU)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>89</p>
|
||
<p>(2 studies)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias,</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The mean ADHD symptoms (total, self, barkley, 0-54, high is poor, fv, <3 months fu) in the control groups was 22.34</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, barkley, 0-54, high is poor, fv, <3 months fu) in the intervention groups was</p>
|
||
<p>8.23 lower (11.86 lower to 4.61 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, Barkley, 0-27, high is poor, FV, <3 months PT)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>104</p>
|
||
<p>(2 studies)</p>
|
||
<p>8-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The mean ADHD symptoms (hyperactivity, self, barkley, 0-27, high is poor, fv, <3 months pt) in the control groups was 7.86</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, barkley, 0-27, high is poor, fv, <3 months pt) in the intervention groups was</p>
|
||
<p>1.36 lower (3.46 lower to 0.74 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, Barkley, 0-27, high is poor, FV, <3 months FU)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>89</p>
|
||
<p>(2 studies)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, barkley, 0-27, high is poor, fv, <3 months fu) in the control groups was</p>
|
||
<p>8.16</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, barkley, 0-27, high is poor, fv, <3 months fu) in the intervention groups was</p>
|
||
<p>2.97 lower (4.90 to 1.03 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, Barkley, 0-27, high is poor, FV, <3 months PT)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>104</p>
|
||
<p>(2 studies)</p>
|
||
<p>8-12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The mean ADHD symptoms (inattention, self, barkley, 0-27, high is poor, fv, <3 months pt) in the control groups was 13.71</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, barkley, 0-27, high is poor, fv, <3 months pt) in the intervention groups was</p>
|
||
<p>3.63 lower (5.55 to 1.71 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, Barkley, 0-27, high is poor, FV, <3 months FU)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>89</p>
|
||
<p>(2 studies)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The mean ADHD symptoms (inattention, self, barkley, 0-27, high is poor, fv, <3 months fu) in the control groups was 14.19</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, barkley, 0-27, high is poor, fv, <3 months fu) in the intervention groups was</p>
|
||
<p>5.26 lower (7.60 to 2.93 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Responders by CGI (two point change in CGI-S, >3 months PT)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>31</p>
|
||
<p>(1 study)</p>
|
||
<p>15 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 4.22</p>
|
||
<p>(1.08 to 16.45)</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1 hd_h_ch6.tab32_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">133 per 1000</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>428 more per 1000</p>
|
||
<p>(from 11 more to 1000 more)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (observer, HAM-D, 0-53, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>31</p>
|
||
<p>(1 study)</p>
|
||
<p>15 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (observer, ham-d, 0-53, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>10</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (observer, ham-d, 0-53, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>5.56 lower</p>
|
||
<p>(9.71 to 1.41 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-64, high is worse, FV, <3 months PT)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>68</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-64, high is worse, fv, <3 months PT) in the control groups was</p>
|
||
<p>14</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-64, high is worse, fv, <3 months pt) in the intervention groups was</p>
|
||
<p>5.62 lower</p>
|
||
<p>(9.85 to 1.39 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-64, high is worse, FV, <3 months FU)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>53</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-64, high is worse, fv, <3 months fu) in the control groups was</p>
|
||
<p>13.14</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-64, high is worse, fv, <3 months fu) in the intervention groups was</p>
|
||
<p>8.10 lower</p>
|
||
<p>(11.72 to 4.43 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (Self rated, RATE antisocial scale, unclear range, high is worse, FV, <3 months PT)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>68</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (rate antisocial scale, unclear range, high is worse, fv, <3 months pt) in the control groups was</p>
|
||
<p>10.29</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (rate antisocial scale, unclear range, high is worse, fv, <3 months pt) in the intervention groups was</p>
|
||
<p>1.05 lower</p>
|
||
<p>(1.99 to 0.11 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behaviour/function (Self rated, RATE antisocial scale, unclear range, high is worse, FV, <3 months FU)</td><td headers="hd_h_ch6.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>57</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab32_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab32_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (rate antisocial scale, unclear range, high is worse, fv, <3 months fu) in the control groups was</p>
|
||
<p>11.19</p>
|
||
</td><td headers="hd_h_ch6.tab32_1_1_1_5 hd_h_ch6.tab32_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean behaviour/function (rate antisocial scale, unclear range, high is worse, fv, <3 months fu) in the intervention groups was</p>
|
||
<p>2.43 lower</p>
|
||
<p>(3.97 to 0.89 lower)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab32_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab32_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab33" class="table"><h3><span class="label">Table 33</span><span class="title">Clinical evidence summary: mixed medication + CBT/DBT versus mixed medication + NSST</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab33/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab33_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab33_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab33_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab33_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab33_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab33_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab33_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab33_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab33_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab33_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab33_1_1_1_5" id="hd_h_ch6.tab33_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Medication + NSST</th><th headers="hd_h_ch6.tab33_1_1_1_5" id="hd_h_ch6.tab33_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Medication + CBT/DBT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">QoL (QLESQ, unclear scale, high is better, FV, >3 months PT)</td><td headers="hd_h_ch6.tab33_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>32</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab33_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab33_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean qol (qlesq, unclear scale, high is better, fv, >3 months pt) in the control groups was</p>
|
||
<p>207.4</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean qol (qlesq, unclear scale, high is better, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>33.10 higher</p>
|
||
<p>(35.83 lower to 102.03 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, high is worse, FV, 0-54, >3 months PT)</td><td headers="hd_h_ch6.tab33_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>110</p>
|
||
<p>(2 studies)</p>
|
||
<p>12-15 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab33_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab33_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Control group results unavailable</td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, ADHD-rs, high is worse, fv, 0-54, >3 months pt) in the intervention groups was</p>
|
||
<p>0.33 standard deviations lower</p>
|
||
<p>(0.7 lower to 0.05 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, ADHD-RS, high is worse, FV, 0-54, >3 months FU)</td><td headers="hd_h_ch6.tab33_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>70</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab33_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab33_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, ADHD-rs, high is worse, fv, 0-54, >3 months fu) in the control groups was</p>
|
||
<p>16.97</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, ADHD-rs, high is worse, fv, 0-54, >3 months fu) in the intervention groups was</p>
|
||
<p>3.58 lower</p>
|
||
<p>(6.34 to 0.82 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, self, CAARS, high is worse, FV, 0-27, >3 months PT)</td><td headers="hd_h_ch6.tab33_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>32</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab33_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab33_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, caars, high is worse, fv, 0-27, >3 months pt) in the control groups was</p>
|
||
<p>13.88</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, self, caars, high is worse, fv, 0-27, >3 months pt) in the intervention groups was</p>
|
||
<p>1.72 higher</p>
|
||
<p>(4.41 lower to 7.85 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, self, CAARS, high is worse, FV, 0-27, >3 months PT)</td><td headers="hd_h_ch6.tab33_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>32</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab33_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab33_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, caars, high is worse, fv, 0-27, >3 months pt) in the control groups was</p>
|
||
<p>18.58</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, self, caars, high is worse, fv, 0-27, >3 months pt) in the intervention groups was</p>
|
||
<p>1.35 higher</p>
|
||
<p>(4.62 lower to 7.32 higher)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab33_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">CGI-I responders (>3 months PT)</td><td headers="hd_h_ch6.tab33_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>78</p>
|
||
<p>(1 study)</p>
|
||
<p>15 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab33_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab33_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>RR 2.21</p>
|
||
<p>(1.17 to 4.16)</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_1 hd_h_ch6.tab33_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">243 per 1000</td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>294 more per 1000</p>
|
||
<p>(from 41 more to 768 more)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-63, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab33_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>32</p>
|
||
<p>(1 study)</p>
|
||
<p>12 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch6.tab33_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab33_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-63, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>13.64</p>
|
||
</td><td headers="hd_h_ch6.tab33_1_1_1_5 hd_h_ch6.tab33_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-63, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>1.24 lower</p>
|
||
<p>(9.37 lower to 6.89 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab33_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab33_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab34" class="table"><h3><span class="label">Table 34</span><span class="title">Clinical evidence summary: Stimulants + CBT/DBT compared to NSST alone</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab34/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab34_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab34_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch6.tab34_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch6.tab34_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch6.tab34_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch6.tab34_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch6.tab34_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch6.tab34_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch6.tab34_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch6.tab34_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch6.tab34_1_1_1_5" id="hd_h_ch6.tab34_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with NSST alone</th><th headers="hd_h_ch6.tab34_1_1_1_5" id="hd_h_ch6.tab34_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Stimulants + CBT/DBT (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, self, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab34_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>206</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab34_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab34_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>18</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, self, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>2.70 lower</p>
|
||
<p>(4.45 to 0.95 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (total, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab34_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>206</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab34_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab34_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>17.5</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (total, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>2.60 lower</p>
|
||
<p>(4.49 to 0.71 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (hyperactivity, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab34_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>206</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab34_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab34_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>15.2</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (hyperactivity, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>2.20 lower</p>
|
||
<p>(4.02 to 0.38 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADHD symptoms (inattention, observer, CAARS, 0-30, high is worse, FV, >3 months PT)</td><td headers="hd_h_ch6.tab34_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>206</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>LOW<sup><a class="bk_pop" href="#ch6.tab34_1">a</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch6.tab34_2">b</a></sup></p>
|
||
<p>due to risk of bias, imprecision</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, high is worse, fv, >3 months pt) in the control groups was</p>
|
||
<p>17.5</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean ADHD symptoms (inattention, observer, caars, high is worse, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>2.50 lower</p>
|
||
<p>(4.32 to 0.68 lower)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional dysregulation (Self, BDI, 0-63, high is poor, FV, >3 months PT)</td><td headers="hd_h_ch6.tab34_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>206</p>
|
||
<p>(1 study)</p>
|
||
<p>52 weeks</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>MODERATE<sup><a class="bk_pop" href="#ch6.tab34_1">a</a></sup></p>
|
||
<p>due to risk of bias</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-63, high is poor, fv, >3 months pt) in the control groups was</p>
|
||
<p>10.1</p>
|
||
</td><td headers="hd_h_ch6.tab34_1_1_1_5 hd_h_ch6.tab34_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>The mean emotional dysregulation (bdi, 0-63, high is poor, fv, >3 months pt) in the intervention groups was</p>
|
||
<p>1.20 lower</p>
|
||
<p>(3.30 lower to 0.90 higher)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab34_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab34_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab35" class="table"><h3><span class="label">Table 35</span><span class="title">Health economic evidence profile: CBT added to medication versus medication alone in adults on medication but with clinically significant symptoms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab35/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab35_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch6.tab35_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Applicability</th><th id="hd_h_ch6.tab35_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Limitations</th><th id="hd_h_ch6.tab35_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Other comments</th><th id="hd_h_ch6.tab35_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Incremental cost</th><th id="hd_h_ch6.tab35_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Incremental effects</th><th id="hd_h_ch6.tab35_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Costeffectiveness</th><th id="hd_h_ch6.tab35_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Uncertainty</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CG72 Original analysis<a class="bk_pop" href="#ch6.r45"><sup>45</sup></a> [UK]</td><td headers="hd_h_ch6.tab35_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Directly applicable<sup><a class="bk_pop" href="#ch6.tab35_1">(a)</a></sup></td><td headers="hd_h_ch6.tab35_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Potentially serious limitations<sup><a class="bk_pop" href="#ch6.tab35_2">(b)</a></sup></td><td headers="hd_h_ch6.tab35_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Decision tree model with 1 year time horizon comparing adding 15 weeks of individual CBT on top of medication versus medication alone (in adults with ADHD who have been stabilised on medication and continue to show clinically significant symptoms).</p>
|
||
<p>Clinical effectiveness from a single RCT (Safren 2005<a class="bk_pop" href="#ch6.r51"><sup>51</sup></a>).</p>
|
||
<p>Includes only CBT costs.</p>
|
||
</td><td headers="hd_h_ch6.tab35_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,122</td><td headers="hd_h_ch6.tab35_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.016</td><td headers="hd_h_ch6.tab35_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£65,279</td><td headers="hd_h_ch6.tab35_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>No probabilistic analysis.</p>
|
||
<p>Various one way sensitivity analyses and threshold analyses tested.</p>
|
||
<p>The ICER stayed above the threshold under all scenarios but group CBT. However this varied wildly (from £13,566 to £535,556 per QALY in the various alternative hypotheses tested).</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">Abbreviations: ICER: incremental cost-effectiveness ratio; QALY: quality-adjusted life years; RCT: randomised controlled trial; CBT: Cognitive behavioural Therapy.</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab35_1"><p class="no_margin">UK NHS perspective. Directly relevant comparisons to the question.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab35_2"><p class="no_margin">Based only on one study with 31 participants. Includes only intervention costs – no other cost savings utilities from a study comparing two doses of atomoxetine and may not reflect utilities associated with behavioural therapy. Extrapolation of effect over 1 year time horizon. Assuming tin the sensitivity analysis that group CBT is as effective as individual CBT. No probabilistic sensitivity analysis.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab36" class="table"><h3><span class="label">Table 36</span><span class="title">Health economic evidence profile: combination of Atomoxetine + behavioural therapy versus atomoxetine versus behavioural therapy, in children</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab36/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab36_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch6.tab36_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Applicability</th><th id="hd_h_ch6.tab36_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Limitations</th><th id="hd_h_ch6.tab36_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Other comments</th><th id="hd_h_ch6.tab36_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Incremental cost</th><th id="hd_h_ch6.tab36_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Incremental effects (QALYs)</th><th id="hd_h_ch6.tab36_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Costeffectiveness</th><th id="hd_h_ch6.tab36_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Uncertainty</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Original NICE analysis [UK]</td><td headers="hd_h_ch6.tab36_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Directly applicable<sup><a class="bk_pop" href="#ch6.tab36_1">(a)</a></sup></td><td headers="hd_h_ch6.tab36_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Potentially serious limitations<sup><a class="bk_pop" href="#ch6.tab36_2">(b)</a></sup></td><td headers="hd_h_ch6.tab36_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Decision tree model with 1 year time horizon comparing; atomoxetine combined with behavioural therapy, behavioural therapy, and atomoxetine, in children.</p>
|
||
<p>Clinical effectiveness is from 3 studies included in the clinical review (with trial periods of around 10 weeks) that had relevant dichotomous outcomes. Includes adverse events from ATX.</p>
|
||
<p>Cost included are the intervention costs, including staff costs for monitoring drug and staff resource use also used to represent costs associated with response/no response. Utilities associated with response/no response included and combined with costs to derive cost per QALY.</p>
|
||
</td><td headers="hd_h_ch6.tab36_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ATX versus BT = £732</p>
|
||
<p>Combination versus ATX = £227</p>
|
||
</td><td headers="hd_h_ch6.tab36_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ATX versus BT = 0.017</p>
|
||
<p>Combination versus ATX = 0.004</p>
|
||
</td><td headers="hd_h_ch6.tab36_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>ATX versus BT = £44,175</p>
|
||
<p>Combination versus ATX = £56,219</p>
|
||
<p>Behavioural therapy most cost effective.</p>
|
||
<p>Net benefits:</p>
|
||
<p>BT = £14,589</p>
|
||
<p>ATX = £14,197</p>
|
||
<p>Combination = £14,051</p>
|
||
</td><td headers="hd_h_ch6.tab36_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Base case results were probabilistic based on 10,000 simulations.</p>
|
||
<p>Various one way sensitivity analyses were tested;
|
||
<dl id="ch6.l4" class="temp-labeled-list"><dt>-</dt><dd id="ch6.lt16"><p class="no_top_margin">assuming response from behavioural therapy diminishes after treatment ends; BT still most cost effective.</p></dd><dt>-</dt><dd id="ch6.lt17"><p class="no_top_margin">BT on an individual basis; ATX most cost effective.</p></dd><dt>-</dt><dd id="ch6.lt18"><p class="no_top_margin">Using alternative source of utility data; BT still most cost effective.</p></dd></dl></p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">Abbreviations: ICER: incremental cost-effectiveness ratio; QALY: quality-adjusted life years; RCT: BT: behavioural therapy; ATX: Atomoxetine</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab36_1"><p class="no_margin">UK NHS perspective. Directly relevant comparisons to the question. Uses EQ-5D.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab36_2"><p class="no_margin">Based only on three trials, with varying intensity of particularly behavioural therapy interventions. No assumptions made about further sequences of treatments which may be underestimating QALYs/costs. Extrapolation of effect for behavioural therapy. No deterioration of the condition or impact of effect modelled over time.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab37" class="table"><h3><span class="label">Table 37</span><span class="title">Health economic evidence profile: Methylphenidate + self-help behavioural therapy versus methylphenidate, in children on methylphenidate but with functional impairment</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab37/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab37_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch6.tab37_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Applicability</th><th id="hd_h_ch6.tab37_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Limitations</th><th id="hd_h_ch6.tab37_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Other comments</th><th id="hd_h_ch6.tab37_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Incremental cost</th><th id="hd_h_ch6.tab37_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Incremental effects (QALYs)</th><th id="hd_h_ch6.tab37_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Costeffectiveness</th><th id="hd_h_ch6.tab37_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Uncertainty</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Original NICE analysis [UK]</td><td headers="hd_h_ch6.tab37_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Directly applicable<sup><a class="bk_pop" href="#ch6.tab37_1">(a)</a></sup></td><td headers="hd_h_ch6.tab37_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Potentially serious limitations<sup><a class="bk_pop" href="#ch6.tab37_2">(b)</a></sup></td><td headers="hd_h_ch6.tab37_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Decision tree model with 1 year time horizon comparing; adding telephone assisted self-help behavioural therapy to MPH versus staying on MPH alone (in a population of children who are partial responders to the MPH).</p>
|
||
<p>Clinical effectiveness is from a single study (trial length of 12 months) that had relevant dichotomous outcomes.</p>
|
||
<p>Costs included are only the costs of the behavioural therapy. Utilities associated with response/no response included and combined with costs to derive cost per QALY.</p>
|
||
</td><td headers="hd_h_ch6.tab37_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£868</td><td headers="hd_h_ch6.tab37_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.0076</td><td headers="hd_h_ch6.tab37_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£114,803</td><td headers="hd_h_ch6.tab37_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Base case results were probabilistic based on 10,000 simulations.</p>
|
||
<p>Various threshold and sensitivity analyses (SA’s) were tested;
|
||
<dl id="ch6.l5" class="temp-labeled-list"><dt>-</dt><dd id="ch6.lt19"><p class="no_top_margin">Threshold analyses; cost of intervention would have to be below £151 to make intervention cost effective, equating to 2-3 sessions. Incremental QALY would have to be 0.0434. Time horizon Would have to be around 3 years.</p></dd><dt>-</dt><dd id="ch6.lt20"><p class="no_top_margin">Assuming effect increases linearly to 6 months as the phone calls are more intense up until that point, and stays at that level until 12 months (ICER = £76,407).</p></dd><dt>-</dt><dd id="ch6.lt21"><p class="no_top_margin">2-way SA varying baseline response probability and intervention response RR showed that no level of combination of baseline risk and RR would make the intervention cost effective.</p></dd><dt>-</dt><dd id="ch6.lt22"><p class="no_top_margin">2-way SA varying time horizon and utility gain showed that intervention can be cost effective if time horizon is generally over 3 years.</p></dd><dt>-</dt><dd id="ch6.lt23"><p class="no_top_margin">Using alternative sources of utility data; ICER still remained high.</p></dd></dl></p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">Abbreviations: ICER: incremental cost-effectiveness ratio; QALY: quality-adjusted life years; RR: relative risk; BT: behavioural therapy; MPH: methylphenidate (a) UK NHS perspective. Directly relevant comparisons to the question. Uses EQ-5D.</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab37_1"><p class="no_margin">UK NHS perspective. Directly relevant comparisons to the question. Uses EQ-5D.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab37_2"><p class="no_margin">Effect based only on one study. No assumptions made about other treatments or impact of behavioural therapy on the underlying resource use. No deterioration of the condition or impact of effect modelled over time. Effect felt to be underestimated.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab38" class="table"><h3><span class="label">Table 38</span><span class="title">Health economic evidence profile: Medication + CBT versus medication, in adolescents on medication but with clinically significant symptoms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab38/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab38_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch6.tab38_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Applicability</th><th id="hd_h_ch6.tab38_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Limitations</th><th id="hd_h_ch6.tab38_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Other comments</th><th id="hd_h_ch6.tab38_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Incremental cost</th><th id="hd_h_ch6.tab38_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Incremental effects</th><th id="hd_h_ch6.tab38_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Cost-effectiveness</th><th id="hd_h_ch6.tab38_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Uncertainty</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Original NICE analysis [UK]</td><td headers="hd_h_ch6.tab38_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Directly applicable<sup><a class="bk_pop" href="#ch6.tab38_1">(a)</a></sup></td><td headers="hd_h_ch6.tab38_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Potentially serious limitations<sup><a class="bk_pop" href="#ch6.tab38_2">(b)</a></sup></td><td headers="hd_h_ch6.tab38_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Decision tree model with 1 year time horizon comparing; adding individual CBT on to medication versus staying on medication alone (in a population of adolescents partially responsive to medication).</p>
|
||
<p>Clinical effectiveness is from a single study (trial length of 4 months) that had relevant dichotomous outcomes.</p>
|
||
<p>Costs included are only the costs of the CBT. Utilities associated with response/no response included and combined with costs to derive cost per QALY.</p>
|
||
</td><td headers="hd_h_ch6.tab38_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,164</td><td headers="hd_h_ch6.tab38_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.0188</td><td headers="hd_h_ch6.tab38_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£62,007</td><td headers="hd_h_ch6.tab38_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Base case results were probabilistic based on 10,000 simulations.</p>
|
||
<p>Various threshold and sensitivity analyses (SA’s) were tested;
|
||
<dl id="ch6.l6" class="temp-labeled-list"><dt>-</dt><dd id="ch6.lt24"><p class="no_top_margin">Cost of intervention would have to be below £375 to make the intervention cost effective. Incremental QALY would have to be 0.0582. Time horizon would have to be 2.8 years.</p></dd><dt>-</dt><dd id="ch6.lt25"><p class="no_top_margin">Assuming the added effect of CBT diminishes after treatment ends (ICER = £105,192).</p></dd><dt>-</dt><dd id="ch6.lt26"><p class="no_top_margin">2-way SA varying baseline response probability and intervention response RR showed that no level of combination of baseline risk and RR would make the intervention cost effective.</p></dd><dt>-</dt><dd id="ch6.lt27"><p class="no_top_margin">2-way SA varying time horizon and utility gain showed that intervention can be cost effective with a longer time horizon of 2-4 years depending on utilty gain.</p></dd><dt>-</dt><dd id="ch6.lt28"><p class="no_top_margin">Using alternative sources of utility data; ICER still remained high.</p></dd></dl></p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">Abbreviations: ICER: incremental cost-effectiveness ratio; QALY: quality-adjusted life years; CBT: Cognitive behavioural Therapy; RR: relative risk</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab38_1"><p class="no_margin">UK NHS perspective. Directly relevant comparisons to the question. Used EQ-5D.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab38_2"><p class="no_margin">Effect based only on one study. No assumptions made about other treatments or impact of behavioural therapy on the underlying resource use. No deterioration of the condition or impact of effect modelled over time. Effect felt to be underestimated.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab39" class="table"><h3><span class="label">Table 39</span><span class="title">UK costs of ADHD drugs for children</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab39/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab39_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Drug</th><th id="hd_h_ch6.tab39_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Daily dose (or unit or total)</th><th id="hd_h_ch6.tab39_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Cost (per unit)</th><th id="hd_h_ch6.tab39_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Cost – monthly</th><th id="hd_h_ch6.tab39_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Cost – annual</th><th id="hd_h_ch6.tab39_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Source</th></tr></thead><tbody><tr><th headers="hd_h_ch6.tab39_1_1_1_1 hd_h_ch6.tab39_1_1_1_2 hd_h_ch6.tab39_1_1_1_3 hd_h_ch6.tab39_1_1_1_4 hd_h_ch6.tab39_1_1_1_5 hd_h_ch6.tab39_1_1_1_6" id="hd_b_ch6.tab39_1_1_1_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Methylphenidate hydrochloride</th></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methylphenidate immediate release</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>10mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>5mg tablet (pack of 30)</p>
|
||
<p>= £3.03</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£6.14</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£73.73</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methylphenidate immediate release</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>60mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>20mg tablet (pack of 30)</p>
|
||
<p>= £10.92</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£33.22</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£398.58</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modified release tablet</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>18mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>18mg tablet (pack of 30)</p>
|
||
<p>= £31.19</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£31.62</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£379.48</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modified release tablet</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>54mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>54mg tablet (pack of 30)</p>
|
||
<p>= £60.48</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£61.32</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£735.84</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modified release capsule</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>20mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>20mg capsule (pack of 30)</p>
|
||
<p>= £30.00</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£30.42</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£365.00</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modified release capsule</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>60 mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>60mg capsule (pack of 30)</p>
|
||
<p>= £67.32</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£68.26</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£819.06</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (NHS indicative price)<sup><a class="bk_pop" href="#ch6.tab39_1">(a)</a></sup></p>
|
||
</td></tr><tr><th headers="hd_h_ch6.tab39_1_1_1_1 hd_h_ch6.tab39_1_1_1_2 hd_h_ch6.tab39_1_1_1_3 hd_h_ch6.tab39_1_1_1_4 hd_h_ch6.tab39_1_1_1_5 hd_h_ch6.tab39_1_1_1_6" id="hd_b_ch6.tab39_1_1_8_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Atomoxetine</th></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Capsule</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>40 mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>40mg capsule (pack of 28)</p>
|
||
<p>= £53.09</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£57.67</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£692.07</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Capsule</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>100 mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>100mg capsule (pack of 28)</p>
|
||
<p>= £70.79</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£76.90</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£922.80</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Oral solution</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>100 mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>4mg/1ml oral solution (300 ml)</p>
|
||
<p>= £85</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£215.45</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£2,585.42</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Using equivalent high tablet dose</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><th headers="hd_h_ch6.tab39_1_1_1_1 hd_h_ch6.tab39_1_1_1_2 hd_h_ch6.tab39_1_1_1_3 hd_h_ch6.tab39_1_1_1_4 hd_h_ch6.tab39_1_1_1_5 hd_h_ch6.tab39_1_1_1_6" id="hd_b_ch6.tab39_1_1_12_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Dexamfetamine</th></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tablet</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>5mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>5mg tablet (pack of 28)</p>
|
||
<p>= £21.53</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£23.39</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£280.66</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tablet</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>20mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>10mg tablet (pack of 30)</p>
|
||
<p>= £39.78</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£80.67</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£967.98</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Oral solution</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>20mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>5mg/5ml oral solution (500ml)</p>
|
||
<p>= £114.49</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£139.30</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,671.55</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Using equivalent high tablet dose</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><th headers="hd_h_ch6.tab39_1_1_1_1 hd_h_ch6.tab39_1_1_1_2 hd_h_ch6.tab39_1_1_1_3 hd_h_ch6.tab39_1_1_1_4 hd_h_ch6.tab39_1_1_1_5 hd_h_ch6.tab39_1_1_1_6" id="hd_b_ch6.tab39_1_1_16_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Lisdexamfetamine</th></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>20mg per day<sup><a class="bk_pop" href="#ch6.tab39_2">(b)</a></sup></p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>20mg capsule (pack of 28)</p>
|
||
<p>= £54.62</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£59.33</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£712.01</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: guideline committee</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>30mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>30mg capsule (pack of 28)</p>
|
||
<p>= £58.24</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£63.27</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£759.20</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>70mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>70mg capsule (pack of 28)</p>
|
||
<p>= £83.16</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£90.34</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,084.05</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><th headers="hd_h_ch6.tab39_1_1_1_1 hd_h_ch6.tab39_1_1_1_2 hd_h_ch6.tab39_1_1_1_3 hd_h_ch6.tab39_1_1_1_4 hd_h_ch6.tab39_1_1_1_5 hd_h_ch6.tab39_1_1_1_6" id="hd_b_ch6.tab39_1_1_20_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Other drugs<sup><a class="bk_pop" href="#ch6.tab39_3">(c)</a></sup></th></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guanfacine hydrochloride (modified release)</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>4mg tablet (pack of 28)</p>
|
||
<p>= £76.16</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£82.73</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£992.80</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (NHS indicative price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Clonidine hydrochloride</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">400 micrograms per day<sup><a class="bk_pop" href="#ch6.tab39_4">(d)</a></sup></td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>100 microgram tablet (pack of 112)</p>
|
||
<p>= £8.04</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£8.73</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£104.81</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risperidone</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>1mg tablet (pack of 20)</p>
|
||
<p>= £0.80</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£2.43</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£29.20</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Amantadine hydrochloride</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">150mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>100mg tablet (pack of 56)</p>
|
||
<p>= £41.00</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£33.40</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£400.85</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Melatonin (modified release)</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>2mg tablet (pack of 30)</p>
|
||
<p>= £15.39</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£46.81</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£561.74</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bupropion hydrochloride (modified release)</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">150mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>150mg tablet (pack of 60)</p>
|
||
<p>= £41.76</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£21.17</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£254.04</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modafinil</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">300mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>100mg tablet (pack of 30)</p>
|
||
<p>= £5.88</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£17.89</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£214.62</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Buspirone hydrochloride</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>10mg tablet (pack of 30)</p>
|
||
<p>= £4.63</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£14.08</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£169.00</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Aripiprazole</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>10mg tablet (pack of 28)</p>
|
||
<p>= £2.77</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£6.02</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£72.22</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab39_1_1_1_1 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Venlafaxine hydrochloride</td><td headers="hd_h_ch6.tab39_1_1_1_2 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75mg per day</td><td headers="hd_h_ch6.tab39_1_1_1_3 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>37.5mg tablet (pack of 56)</p>
|
||
<p>= £2.04</p>
|
||
</td><td headers="hd_h_ch6.tab39_1_1_1_4 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£2.22</td><td headers="hd_h_ch6.tab39_1_1_1_5 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£26.59</td><td headers="hd_h_ch6.tab39_1_1_1_6 hd_b_ch6.tab39_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">Source: BNF, October 2017.</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab39_1"><p class="no_margin">No drug tariff price available for the 60mg.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab39_2"><p class="no_margin">A dose of 20mg is demonstrated here as committee opinion was that this is a dose that would be used in children, even though it is below the BNF starting dose.</p></div></dd><dt>(c)</dt><dd><div id="ch6.tab39_3"><p class="no_margin">Guanfacine is the only drug from this list licensed for ADHD. It is less commonly used and is a newer drug so one example dose within the licensed range is demonstrated here. The doses of the other drugs below guanfacine were taken from the clinical review as there was no information in the BNF about doses for this condition.</p></div></dd><dt>(d)</dt><dd><div id="ch6.tab39_4"><p class="no_margin">Based on a dose from a trial of 8micrograms per kg and assuming a 50kg child (a conservative estimate of weight)</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab40" class="table"><h3><span class="label">Table 40</span><span class="title">UK costs of ADHD drugs for adults</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab40/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab40_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Drug</th><th id="hd_h_ch6.tab40_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Daily dose (or unit or total)</th><th id="hd_h_ch6.tab40_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Cost (per unit)</th><th id="hd_h_ch6.tab40_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Cost – monthly</th><th id="hd_h_ch6.tab40_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Cost – annual</th><th id="hd_h_ch6.tab40_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Source of dose</th></tr></thead><tbody><tr><th headers="hd_h_ch6.tab40_1_1_1_1 hd_h_ch6.tab40_1_1_1_2 hd_h_ch6.tab40_1_1_1_3 hd_h_ch6.tab40_1_1_1_4 hd_h_ch6.tab40_1_1_1_5 hd_h_ch6.tab40_1_1_1_6" id="hd_b_ch6.tab40_1_1_1_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Methylphenidate hydrochloride</th></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methylphenidate immediate release</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>20mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>10mg tablet (pack of 30)</p>
|
||
<p>= £5.49</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£11.13</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£133.59</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methylphenidate immediate release</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>100mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">As above</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£55.36</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£664.30</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modified release tablet</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>36mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>36mg tablet (pack of 30)</p>
|
||
<p>= £42.45</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£43.04</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£516.48</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modified release tablet</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>108mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>54mg tablet<sup><a class="bk_pop" href="#ch6.tab40_1">(a)</a></sup> (pack of 30)</p>
|
||
<p>= £60.48</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£122.64</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,471.68</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modified release capsule</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>20mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>20mg capsule (pack of 30)</p>
|
||
<p>= £30.00</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£30.42</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£365.00</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Modified release capsule</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>100mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>50mg capsule (pack of 30)</p>
|
||
<p>= £62.52</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£126.78</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,521.32</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (NHS indicative price)<sup><a class="bk_pop" href="#ch6.tab40_1">(a)</a></sup></p>
|
||
</td></tr><tr><th headers="hd_h_ch6.tab40_1_1_1_1 hd_h_ch6.tab40_1_1_1_2 hd_h_ch6.tab40_1_1_1_3 hd_h_ch6.tab40_1_1_1_4 hd_h_ch6.tab40_1_1_1_5 hd_h_ch6.tab40_1_1_1_6" id="hd_b_ch6.tab40_1_1_8_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Atomoxetine</th></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>40 mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>40mg tablet (pack of 28)</p>
|
||
<p>= £53.09</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£57.67</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£692.07</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>100 mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>100mg tablet (pack of 28)</p>
|
||
<p>= £70.79</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£92.28</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,107.36</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><th headers="hd_h_ch6.tab40_1_1_1_1 hd_h_ch6.tab40_1_1_1_2 hd_h_ch6.tab40_1_1_1_3 hd_h_ch6.tab40_1_1_1_4 hd_h_ch6.tab40_1_1_1_5 hd_h_ch6.tab40_1_1_1_6" id="hd_b_ch6.tab40_1_1_11_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Lisdexamfetamine dimesylate</th></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>30 mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>30mg tablet (pack of 28)</p>
|
||
<p>= £58.24</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£63.27</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£759.20</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>70 mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>70mg tablet (pack of 28)</p>
|
||
<p>= £83.16</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£90.34</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,084.05</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><th headers="hd_h_ch6.tab40_1_1_1_1 hd_h_ch6.tab40_1_1_1_2 hd_h_ch6.tab40_1_1_1_3 hd_h_ch6.tab40_1_1_1_4 hd_h_ch6.tab40_1_1_1_5 hd_h_ch6.tab40_1_1_1_6" id="hd_b_ch6.tab40_1_1_14_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Dexamfetamine sulfate</th></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Low dose:</p>
|
||
<p>20mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>10mg tablet (pack of 30)</p>
|
||
<p>= £39.78</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£80.67</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£967.98</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>High dose:</p>
|
||
<p>60mg per day</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>20mg tablet (pack of 30)</p>
|
||
<p>= £79.56</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£161.33</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£1,935.96</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: BNF</p>
|
||
<p>Cost: BNF (NHS indicative price)<sup><a class="bk_pop" href="#ch6.tab40_1">(a)</a></sup></p>
|
||
</td></tr><tr><th headers="hd_h_ch6.tab40_1_1_1_1 hd_h_ch6.tab40_1_1_1_2 hd_h_ch6.tab40_1_1_1_3 hd_h_ch6.tab40_1_1_1_4 hd_h_ch6.tab40_1_1_1_5 hd_h_ch6.tab40_1_1_1_6" id="hd_b_ch6.tab40_1_1_17_1" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Other drugs</th></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guanfacine hydrochloride (modified release)</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4mg per day</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>4mg tablet (pack of 28)</p>
|
||
<p>= £76.16</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£82.73</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£992.80</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Estimate based on children’s dose</p>
|
||
<p>Cost: BNF (NHS indicative price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bupropion hydrochloride (modified release)</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">300 mg per day</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>150mg tablet (pack of 60)</p>
|
||
<p>= £41.76</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£42.34</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£508.08</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reboxetine (Edronax)</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8mg per day</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>4mg tablet (pack of 60)</p>
|
||
<p>= £18.91</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£19.17</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£230.07</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr><tr><td headers="hd_h_ch6.tab40_1_1_1_1 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Venlafaxine hydrochloride</td><td headers="hd_h_ch6.tab40_1_1_1_2 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">225 mg per day</td><td headers="hd_h_ch6.tab40_1_1_1_3 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>37.5mg tablet (pack of 56)</p>
|
||
<p>= £2.04</p>
|
||
</td><td headers="hd_h_ch6.tab40_1_1_1_4 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£6.65</td><td headers="hd_h_ch6.tab40_1_1_1_5 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£79.78</td><td headers="hd_h_ch6.tab40_1_1_1_6 hd_b_ch6.tab40_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Dose: Clinical review</p>
|
||
<p>Cost: BNF (DT price)</p>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">Source: BNF, October 2017.</p></div></dd><dt>(a)</dt><dd><div id="ch6.tab40_1"><p class="no_margin">No BNF drug tariff price for this dose yet.</p></div></dd></dl></div></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab41" class="table"><h3><span class="label">Table 41</span><span class="title">Staff costs associated with selecting and monitoring medication treatment</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab41/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab41_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Staff</th><th id="hd_h_ch6.tab41_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Costs</th><th id="hd_h_ch6.tab41_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Source</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychiatric Consultant</td><td headers="hd_h_ch6.tab41_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£106 per hour</td><td headers="hd_h_ch6.tab41_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PSSRU 2016</td></tr><tr><td headers="hd_h_ch6.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Band 5 nurse</td><td headers="hd_h_ch6.tab41_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£36 per hour</td><td headers="hd_h_ch6.tab41_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PSSRU 2016</td></tr></tbody></table></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab42" class="table"><h3><span class="label">Table 42</span><span class="title">Staff costs associated with behavioural therapy</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab42/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab42_lrgtbl__"><table><thead><tr><th id="hd_h_ch6.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Staff</th><th id="hd_h_ch6.tab42_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Costs</th><th id="hd_h_ch6.tab42_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Source</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>Clinical psychologist</p>
|
||
<p>(Band 8a, clinical psychologist principal (community based))</p>
|
||
</td><td headers="hd_h_ch6.tab42_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£62 per hour</td><td headers="hd_h_ch6.tab42_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PSSRU 2016</td></tr><tr><td headers="hd_h_ch6.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Band 4 assistant</td><td headers="hd_h_ch6.tab42_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£30 per hour</td><td headers="hd_h_ch6.tab42_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PSSRU 2016</td></tr></tbody></table></div></div></div><div class="whole_rhythm bk_prnt_obj"><div id="ch6.tab43" class="table"><h3><span class="label">Table 43</span><span class="title">Published PSSRU costs on cognitive behavioural treatments</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578099/table/ch6.tab43/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch6.tab43_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch6.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention</th><th id="hd_h_ch6.tab43_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Details</th><th id="hd_h_ch6.tab43_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Costs</th><th id="hd_h_ch6.tab43_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Source</th></tr></thead><tbody><tr><td headers="hd_h_ch6.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive Behavioural Therapy for adolescents (individual).<sup><a class="bk_pop" href="#ch6.tab43_1">(a)</a></sup></td><td headers="hd_h_ch6.tab43_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Length of contact; 55 minutes (average duration of sessions)</td><td headers="hd_h_ch6.tab43_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£97 per CBT session</td><td headers="hd_h_ch6.tab43_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PSSRU 2016</td></tr><tr><td headers="hd_h_ch6.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mindfulness based cognitive therapy – group based intervention for adults.<sup><a class="bk_pop" href="#ch6.tab43_2">(b)</a></sup></td><td headers="hd_h_ch6.tab43_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Therapy sessions lasted 2 hours with 12 people attending each session.</td><td headers="hd_h_ch6.tab43_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>£52 per hour of non-direct contact,</p>
|
||
<p>£86 per hour of direct contact,</p>
|
||
<p>£173 per session,</p>
|
||
<p>£14 per service user (=£173/12 people)</p>
|
||
</td><td headers="hd_h_ch6.tab43_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PSSRU 2016</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>(a)</dt><dd><div id="ch6.tab43_1"><p class="no_margin">This cost is based on costs estimated for a randomised controlled trial of interventions for adolescents with depression. The setting was two Child and Mental Health Services (CAMHS) teams in secondary care where CBT was delivered.</p></div></dd><dt>(b)</dt><dd><div id="ch6.tab43_2"><p class="no_margin">Mindfulness-based cognitive therapy (MBCT) is a manualised skills training programme designed to enable patients to learn skills that prevent the recurrence of depression. It is derived from mindfulness-based stress reduction, a programme with proven efficacy in ameliorating distress in people suffering chronic disease. To provide the unit costs of this service, we have drawn on information provided by Kuyken et al. (2008) which was based on data from three mindfulness-based cognitive therapy therapists who took part in the study. There were 12 individuals in each group.</p></div></dd></dl></div></div></div></div></div><div><p>Final</p></div><div><p>Intervention evidence review</p><p>These evidence reviews were developed by the National Guideline Centre</p></div><div><p><b>Disclaimer</b>: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.</p><p>Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.</p><p>NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the <a href="http://wales.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Welsh Government</a>, <a href="http://www.scotland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Scottish Government</a>, and <a href="http://www.northernireland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Northern Ireland Executive</a>. All NICE guidance is subject to regular review and may be updated or withdrawn.</p></div></div></div>
|
||
<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2018.</div><div class="small"><span class="label">Bookshelf ID: NBK578099</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/35192260" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">35192260</a></span></div></div></div>
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