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<title>Table 7, Clinical evidence summary: Treatment versus no treatment at systolic blood pressure threshold of 140–159mmHg at low cardiovascular risk (without type 2 diabetes) – non-randomised evidence - Evidence review for initiating treatment - NCBI Bookshelf</title>
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<div class="main-content lit-style"><div class="body-content whole_rhythm"><div id="ch3.tab7" class="table"><h3><span class="label">Table 7</span><span class="title">Clinical evidence summary: Treatment versus no treatment at systolic blood pressure threshold of 140–159mmHg at low cardiovascular risk (without type 2 diabetes) – non-randomised evidence</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK578045/table/ch3.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch3.tab7_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch3.tab7_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch3.tab7_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch3.tab7_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch3.tab7_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch3.tab7_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch3.tab7_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch3.tab7_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch3.tab7_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch3.tab7_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects<sup><a class="bk_pop" href="#ch3.tab7_3">3</a></sup></th></tr><tr><th headers="hd_h_ch3.tab7_1_1_1_5" id="hd_h_ch3.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with No treatment (no diabetes)</th><th headers="hd_h_ch3.tab7_1_1_1_5" id="hd_h_ch3.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Treatment (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch3.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mortality 140–159 mmHg</td><td headers="hd_h_ch3.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>38,286</p>
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||
<p>(1 study)</p>
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||
<p>5.8 years</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>VERY LOW<sup><a class="bk_pop" href="#ch3.tab7_2">2</a></sup></p>
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<p>due to indirectness</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>HR 1.02</p>
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||
<p>(0.88 to 1.18)<sup><a class="bk_pop" href="#ch3.tab7_4">4</a></sup></p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>41 per 1,000</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 more per 1,000 (from 5 fewer to 7 more)</td></tr><tr><td headers="hd_h_ch3.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Stroke 140–159 mmHg</td><td headers="hd_h_ch3.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>38,286</p>
|
||
<p>(1 study)</p>
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||
<p>5.8 years</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>VERY LOW<sup><a class="bk_pop" href="#ch3.tab7_1">1</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch3.tab7_2">2</a></sup></p>
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||
<p>due to, imprecision, indirectness</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>HR 0.97</p>
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||
<p>(0.78 to 1.21)<sup><a class="bk_pop" href="#ch3.tab7_4">4</a></sup></p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 per 1,000</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 fewer per 1,000 (from 3 fewer to 3 more)</td></tr><tr><td headers="hd_h_ch3.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Myocardial Infarction 140–159 mmHg</td><td headers="hd_h_ch3.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>38,286</p>
|
||
<p>(1 study)</p>
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||
<p>5.8 years</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>VERY LOW<sup><a class="bk_pop" href="#ch3.tab7_2">2</a></sup></p>
|
||
<p>due to indirectness</p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>HR 1.00</p>
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||
<p>(0.80 to 1.25)<sup><a class="bk_pop" href="#ch3.tab7_4">4</a></sup></p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 per 1,000</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 fewer per 1,000 (from 3 fewer to 4 more)</td></tr><tr><td headers="hd_h_ch3.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Heart failure 140–159 mmHg</td><td headers="hd_h_ch3.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>38,286</p>
|
||
<p>(1 study)</p>
|
||
<p>5.8 years</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch3.tab7_1">1</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch3.tab7_2">2</a></sup></p>
|
||
<p>due to imprecision, indirectness</p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>HR 1.34</p>
|
||
<p>(0.96 to 1.87)<sup><a class="bk_pop" href="#ch3.tab7_4">4</a></sup></p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7 per 1,000</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 more per 1,000 (from 0 fewer to 6 more)</td></tr><tr><td headers="hd_h_ch3.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-MI acute coronary syndrome 140–159 mmHg</td><td headers="hd_h_ch3.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>38,286</p>
|
||
<p>(1 study)</p>
|
||
<p>5.8 years</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch3.tab7_1">1</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch3.tab7_2">2</a></sup></p>
|
||
<p>due to imprecision, indirectness</p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>HR 1.19</p>
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||
<p>(0.74 to 1.91)<sup><a class="bk_pop" href="#ch3.tab7_4">4</a></sup></p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 per 1,000</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 more per 1,000 (from 1 fewer to 3 more)</td></tr><tr><td headers="hd_h_ch3.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypotension 140–159 mmHg</td><td headers="hd_h_ch3.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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||
<p>38,286</p>
|
||
<p>(1 study)</p>
|
||
<p>5.8 years</p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch3.tab7_2">2</a></sup></p>
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||
<p>due to indirectness</p>
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||
</td><td headers="hd_h_ch3.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>HR 1.69</p>
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||
<p>(1.30 to 2.20)<sup><a class="bk_pop" href="#ch3.tab7_4">4</a></sup></p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8 per 1,000</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6 more per 1,000 (from 3 more to 10 more)</td></tr><tr><td headers="hd_h_ch3.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Acute Kidney Injury 140–159 mmHg</td><td headers="hd_h_ch3.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>38,286</p>
|
||
<p>(1 study)</p>
|
||
<p>5.8 years</p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>VERY LOW<sup><a class="bk_pop" href="#ch3.tab7_1">1</a></sup><sup>,</sup><sup><a class="bk_pop" href="#ch3.tab7_2">2</a></sup></p>
|
||
<p>due to imprecision, indirectness</p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<p>HR 1.37</p>
|
||
<p>(1 to 1.88)<sup><a class="bk_pop" href="#ch3.tab7_4">4</a></sup></p>
|
||
</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8 per 1,000</td><td headers="hd_h_ch3.tab7_1_1_1_5 hd_h_ch3.tab7_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 more per 1,000 (from 0 more to 7 more)</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1</dt><dd><div id="ch3.tab7_1"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs.</p></div></dd><dt>2</dt><dd><div id="ch3.tab7_2"><p class="no_margin">Downgraded by 1 or 2 increments because the majority of the evidence included an indirect or very indirect population respectively.</p></div></dd><dt>3</dt><dd><div id="ch3.tab7_3"><p class="no_margin">Absolute effects calculated by inputting raw event data from median follow up time into GRADE.</p></div></dd><dt>4</dt><dd><div id="ch3.tab7_4"><p class="no_margin">Evidence based on one study that reported HRs with raw event data.</p></div></dd></dl></div></div></div></div></div>
|
||
<div class="post-content"><div><p>From: <a href="/books/NBK578045/" target="mainwindow">Evidence review for initiating treatment</a></p><div class="iconblock clearfix ten_col"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/niceng136er3/" target="mainwindow"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng136er3-lrg.png" alt="Cover of Evidence review for initiating treatment" height="100px" width="80px" /></a><div class="icnblk_cntnt"><div><div>Evidence review for initiating treatment: Hypertension in adults: diagnosis and management: Evidence review C.</div><div class="series-statement">NICE Guideline, No. 136.</div><div>National Guideline Centre (UK).</div><div>London: <a href="https://www.nice.org.uk" target="mainwindow" ref="pagearea=content-footer&targetsite=external&targetcat=link&targettype=publisher">National Institute for Health and Care Excellence (NICE)</a>; 2019 Aug.</div></div></div></div><div class="half_rhythm"><a href="/books/about/copyright/" target="mainwindow">Copyright</a> © NICE 2019.</div><p>NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div>
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