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<div class="main-content lit-style"><div class="body-content whole_rhythm"><div id="ch11.appa.tab1" class="table"><h3><span class="label">Table 2</span><span class="title">Review protocol: Patient information</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK577889/table/ch11.appa.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch11.appa.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Field</th><th id="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Content</th></tr></thead><tbody><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review question</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">What information is useful for people with primary hyperparathyroidism?</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Type of review question</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
<p>Views and experiences (qualitative)</p>
<p>A review of health economic evidence related to the same review question was conducted in parallel with this review. For details see the health economic review protocol for this NICE guideline.</p>
</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objective of the review</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To determine what information should be provided to people with PHPT.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria &#x02013; population</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>Adults (18 years or over) with primary hyperparathyroidism</p><p>Strata:
<ul id="ch11.l2"><li id="ch11.lt3" class="half_rhythm"><div>Post-diagnosis, pre-surgery, post-surgery, people on pharmacological treatment</div></li></ul></p>
<p>Exclude people:
<ul id="ch11.l3"><li id="ch11.lt4" class="half_rhythm"><div>with secondary and tertiary HPT</div></li><li id="ch11.lt5" class="half_rhythm"><div>with multiple endocrine neoplasia</div></li><li id="ch11.lt6" class="half_rhythm"><div>with familial hyperparathyroidism</div></li><li id="ch11.lt7" class="half_rhythm"><div>with parathyroid carcinoma</div></li></ul></p></td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria &#x02013; context</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Any type of information described by studies.
<ul id="ch11.l4"><li id="ch11.lt8" class="half_rhythm"><div>Content of information and how this information is delivered</div></li><li id="ch11.lt9" class="half_rhythm"><div>Information to include pre- and post-surgery</div></li><li id="ch11.lt10" class="half_rhythm"><div>Timing of information and support</div></li></ul></td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria &#x02013; comparator(s)</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes and prioritisation</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Synthesis of qualitative research: thematic analysis &#x02013; information synthesised into main review findings. Results presented in a detailed narrative and in table format with summary statements of main review findings.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria &#x02013; study design</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Qualitative studies (for example, interviews, focus groups, observations)</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other inclusion exclusion criteria</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
<ul id="ch11.l5"><li id="ch11.lt11" class="half_rhythm"><div>Non-English language studies</div></li><li id="ch11.lt12" class="half_rhythm"><div>Conference abstracts</div></li></ul></td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Proposed sensitivity / subgroup analysis, or meta-regression</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Selection process &#x02013; duplicate screening / selection / analysis</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Studies are sifted by title and abstract. Potentially significant publications obtained in full text are then assessed against the inclusion criteria specified in this protocol.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data management (software)</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CERQual will be used to synthesise data from qualitative studies.
<ul id="ch11.l6"><li id="ch11.lt13" class="half_rhythm"><div>Endnote for bibliography, citations, sifting and reference management</div></li><li id="ch11.lt14" class="half_rhythm"><div>Data extractions performed using EviBase, a platform designed and maintained by the National Guideline Centre (NGC)</div></li></ul></td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Information sources &#x02013; databases and dates</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
<p>Clinical search databases to be used: Medline, Embase, CINAHL and PsycINFO</p>
<p>Date: all years</p>
<p>Language: Restrict to English only</p>
<p>Supplementary search techniques: backward citation searching</p>
<p>Key papers: Not known</p>
</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Identify if an update</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Author contacts</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
<a href="https://www.nice.org.uk/guidance/indevelopment/gid-ng10051" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">https://www<wbr style="display:inline-block"></wbr>.nice.org<wbr style="display:inline-block"></wbr>.uk/guidance/indevelopment/gid-ng10051</a>
</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Highlight if amendment to previous protocol</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 4.5 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy &#x02013; for one database</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">[For details please see <a href="/books/NBK577889/#ch11.appb" target="mainwindow">appendix B</a></td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data collection process &#x02013; forms / duplicate</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A standardised evidence table format will be used, and published as <a href="/books/NBK577889/#ch11.appd" target="mainwindow">appendix D</a> of the evidence report.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data items &#x02013; define all variables to be collected</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see evidence tables in <a href="/books/NBK577889/#ch11.appd" target="mainwindow">appendix D</a> (clinical evidence tables) or H (health economic evidence tables).</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for assessing bias at outcome / study level</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
<p>Standard study checklists will be used to critically appraise individual studies. For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Developing NICE guidelines: the manual</a>.</p>
<p>The risk of bias across all available evidence will be evaluated for each outcome using an adaptation of the &#x02018;Grading of Recommendations Assessment, Development and Evaluation (GRADE) toolbox&#x02019; developed by the international GRADE working group <a href="http://www.gradeworkinggroup.org/" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">http://www<wbr style="display:inline-block"></wbr>.gradeworkinggroup.org/</a></p>
</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Criteria for quantitative synthesis</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.4 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for quantitative analysis &#x02013; combining studies and exploring (in)consistency</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the separate Methods report for this guideline.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-bias assessment &#x02013; publication bias, selective reporting bias</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Confidence in cumulative evidence</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see sections 6.4 and 9.1 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rationale / context &#x02013; what is known</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the introduction to the evidence review.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Describe contributions of authors and guarantor</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
<p>A <a href="https://www.nice.org.uk/guidance/indevelopment/gid-ng10051" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">multidisciplinary committee</a> developed the evidence review. The committee was convened by the National Guideline Centre (NGC) and chaired by Jonathan Mant in line with section 3 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Developing NICE guidelines: the manual</a>.</p>
<p>Staff from the NGC undertook systematic literature searches, appraised the evidence, conducted meta-analysis and cost-effectiveness analysis where appropriate, and drafted the evidence review in collaboration with the committee. For details please see <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" target="mainwindow" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">Developing NICE guidelines: the manual</a>.</p>
</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sources of funding / support</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The NGC is funded by NICE and hosted by the Royal College of Physicians.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Name of sponsor</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The NGC is funded by NICE and hosted by the Royal College of Physicians.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Roles of sponsor</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE funds the NGC to develop guidelines for those working in the NHS, public health and social care in England.</td></tr><tr><td headers="hd_h_ch11.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PROSPERO registration number</td><td headers="hd_h_ch11.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not registered</td></tr></tbody></table></div></div></div></div>
<div class="post-content"><div><p>From: <a href="/books/NBK577889/" target="mainwindow">Evidence review for patient information</a></p><div class="iconblock clearfix ten_col"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/niceng132er11/" target="mainwindow"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng132er11-lrg.png" alt="Cover of Evidence review for patient information" height="100px" width="80px" /></a><div class="icnblk_cntnt"><div><div>Evidence review for patient information: Hyperparathyroidism (primary): diagnosis, assessment and initial management: Evidence review K.</div><div class="series-statement">NICE Guideline, No. 132.</div><div>National Guideline Centre (UK).</div><div>London: <a href="https://www.nice.org.uk" target="mainwindow" ref="pagearea=content-footer&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher">National Institute for Health and Care Excellence (NICE)</a>; 2019 May.</div></div></div></div><div class="half_rhythm"><a href="/books/about/copyright/" target="mainwindow">Copyright</a> © NICE 2019.</div><p>NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div>
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