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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Clotiazepam" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/01/15" /><meta name="citation_pmid" content="33630483" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK567881/" /><meta name="citation_keywords" content="Clotiazepam" /><meta name="citation_keywords" content="5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one" /><meta name="citation_keywords" content="5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one" /><meta name="citation_keywords" content="BRN 0623332" /><meta name="citation_keywords" content="Clotiazepamum" /><meta name="citation_keywords" content="EINECS 251-627-3" /><meta name="citation_keywords" content="Rise" /><meta name="citation_keywords" content="Rize" /><meta name="citation_keywords" content="Rizen" /><meta name="citation_keywords" content="Tienor" /><meta name="citation_keywords" content="Trecalmo" /><meta name="citation_keywords" content="UNII-ZCN055599V" /><meta name="citation_keywords" content="Y 6047" /><meta name="citation_keywords" content="Trecalmo" /><meta name="citation_keywords" content="Tienor" /><meta name="citation_keywords" content="Distensan" /><meta name="citation_keywords" content="Veratran" /><meta name="citation_keywords" content="Clozan" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Clotiazepam" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/01/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK567881/" /><meta name="description" content="Clotiazepam is not approved for marketing in the United States by the U.S. Food and Drug Administration. Very little information is available on the passage of clotiazepam into milk. One review recommends avoiding clotiazepam during breastfeeding.[1] An alternate drug is preferred, especially while nursing a newborn or preterm infant. If clotiazepam is used, monitor the infant for sedation, poor feeding and poor weight gain." /><meta name="og:title" content="Clotiazepam" /><meta name="og:type" content="book" /><meta name="og:description" content="Clotiazepam is not approved for marketing in the United States by the U.S. Food and Drug Administration. Very little information is available on the passage of clotiazepam into milk. One review recommends avoiding clotiazepam during breastfeeding.[1] An alternate drug is preferred, especially while nursing a newborn or preterm infant. If clotiazepam is used, monitor the infant for sedation, poor feeding and poor weight gain." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK567881/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/clotiazepam/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK567881/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK567881_"><span class="title" itemprop="name">Clotiazepam</span></h1><p class="small">Last Revision: <span itemprop="dateModified">January 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 33671-46-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/388644649" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=388644649" alt="image 388644649 in the ncbi pubchem database" /></a><div id="clotiazepam.Drug_Levels_and_Effects"><h2 id="_clotiazepam_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="clotiazepam.Summary_of_Use_during_Lactat"><h3>Summary of Use during Lactation</h3><p>Clotiazepam is not approved for marketing in the United States by the U.S. Food and Drug Administration. Very little information is available on the passage of clotiazepam into milk. One review recommends avoiding clotiazepam during breastfeeding.[<a class="bk_pop" href="#clotiazepam.REF.1">1</a>] An alternate drug is preferred, especially while nursing a newborn or preterm infant. If clotiazepam is used, monitor the infant for sedation, poor feeding and poor weight gain.</p></div><div id="clotiazepam.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels. </i>A woman who was taking oral clotiazepam 5 mg daily donated a milk sample between 3 and 6 days postpartum at 1 hour after a dose at the estimated peak serum concentration. She had a 1-hour milk level of 16.3 mcg/L.[<a class="bk_pop" href="#clotiazepam.REF.2">2</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="clotiazepam.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="clotiazepam.Effects_on_Lactation_and_Bre"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="clotiazepam.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM364/">Lorazepam</a>, <a href="/books/n/lactmed/LM377/">Oxazepam</a>, <a href="/books/n/lactmed/LM388/">Temazepam</a></p></div><div id="clotiazepam.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="clotiazepam.REF.1">Bascoul
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C, Franchitto
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L, Parant
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O, et al.
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[Psychotropic drugs during pregnancy and lactation: Development practice]. Presse Med
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2015;44:271–83.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/25595818" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25595818</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="clotiazepam.REF.2">Nishimura
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A, Furugen
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A, Umazume
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T, et al.
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Benzodiazepine concentrations in the breast milk and plasma of nursing mothers: Estimation of relative infant dose.
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Breastfeed Med
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2021;16:424-31.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/33449825" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33449825</span></a>]</div></dd></dl></div></div><div id="clotiazepam.Substance_Identification"><h2 id="_clotiazepam_Substance_Identification_">Substance Identification</h2><div id="clotiazepam.Substance_Name"><h3>Substance Name</h3><p>Clotiazepam</p></div><div id="clotiazepam.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>33671-46-4</p></div><div id="clotiazepam.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Hypnotics and Sedatives</p><p>Anti-Anxiety Agents</p><p>Benzodiazepines</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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