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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Indocyanine Green" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/12/15" /><meta name="citation_pmid" content="33497165" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK566937/" /><meta name="citation_keywords" content="Indocyanine Green" /><meta name="citation_keywords" content="Cardio Green" /><meta name="citation_keywords" content="Fox Green" /><meta name="citation_keywords" content="IC-Green" /><meta name="citation_keywords" content="ICG" /><meta name="citation_keywords" content="IR 125" /><meta name="citation_keywords" content="NK 1611" /><meta name="citation_keywords" content="Ujoviridin" /><meta name="citation_keywords" content="UNII-IX6J1063HV" /><meta name="citation_keywords" content="Wofaverdin}sodium" /><meta name="citation_keywords" content="4-[(2E)-2-[(2E,4E,6E)-7-[1,1-dimethyl-3-(4-sulfonatobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Indocyanine Green" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/12/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK566937/" /><meta name="description" content="Data from one patient indicates that a low subcutaneous dose of indocyanine green is not detectable in breastmilk. The manufacturer reports 17 cases of indocyanine green use in lactating women with no reported adverse effects in infants. Indocyanine green appears to be acceptable during breastfeeding, but it should be used with caution, especially while nursing a newborn or preterm infant." /><meta name="og:title" content="Indocyanine Green" /><meta name="og:type" content="book" /><meta name="og:description" content="Data from one patient indicates that a low subcutaneous dose of indocyanine green is not detectable in breastmilk. The manufacturer reports 17 cases of indocyanine green use in lactating women with no reported adverse effects in infants. Indocyanine green appears to be acceptable during breastfeeding, but it should be used with caution, especially while nursing a newborn or preterm infant." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK566937/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/indocyanine_green/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK566937/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK566937_"><span class="title" itemprop="name">Indocyanine Green</span></h1><p class="small">Last Revision: <span itemprop="dateModified">December 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 3599-32-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/387061007" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=387061007" alt="image 387061007 in the ncbi pubchem database" /></a><div id="indocyanine_green.Drug_Levels_and_Effect"><h2 id="_indocyanine_green_Drug_Levels_and_Effect_">Drug Levels and Effects</h2><div id="indocyanine_green.Summary_of_Use_during"><h3>Summary of Use during Lactation</h3><p>Data from one patient indicates that a low subcutaneous dose of indocyanine green is not detectable in breastmilk. The manufacturer reports 17 cases of indocyanine green use in lactating women with no reported adverse effects in infants. Indocyanine green appears to be acceptable during breastfeeding, but it should be used with caution, especially while nursing a newborn or preterm infant.</p></div><div id="indocyanine_green.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A nursing mother with lower limb lymphedema was given indocyanine green intradermally for lymphangiography. Although the dosage was not stated, the article referred to other papers that used 0.2 mL of a 0.25% solution of indocyanine green injected subcutaneously into both lower extremities, with detection by fluorescent imaging of lymphatic drainage channels using an infrared camera. The mother expressed milk approximately after imaging was complete at about 3 hours after the dose. Observation of the milk was performed with an infrared camera, which revealed no fluorescent enhancement of the milk.[<a class="bk_pop" href="#indocyanine_green.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="indocyanine_green.Effects_in_Breastfed_I"><h3>Effects in Breastfed Infants</h3><p>The manufacturer reports 17 cases of indocyanine green use in lactating women with no adverse events observed in the breastfed infant.</p></div><div id="indocyanine_green.Effects_on_Lactation_a"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="indocyanine_green.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="indocyanine_green.REF.1">Sakai
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H, Tsukuura
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R, Kageyama
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T. Non-enhancement of the breast milk after subcutaneous indocyanine green injection: Is indocyanine green lymphography safe for breast-feeding patients?
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Microsurgery
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2021;41:198-9.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/33398900" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 33398900</span></a>]</div></dd></dl></div></div><div id="indocyanine_green.Substance_Identificati"><h2 id="_indocyanine_green_Substance_Identificati_">Substance Identification</h2><div id="indocyanine_green.Substance_Name"><h3>Substance Name</h3><p>Indocyanine Green</p></div><div id="indocyanine_green.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>3599-32-4</p></div><div id="indocyanine_green.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Coloring Agents</p><p>Diagnostic Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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