114 lines
No EOL
25 KiB
XML
114 lines
No EOL
25 KiB
XML
<?xml version="1.0" encoding="utf-8"?>
|
|
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
|
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
|
|
|
|
<head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
|
<!-- AppResources meta begin -->
|
|
<meta name="paf-app-resources" content="" />
|
|
<script type="text/javascript">var ncbi_startTime = new Date();</script>
|
|
|
|
<!-- AppResources meta end -->
|
|
|
|
<!-- TemplateResources meta begin -->
|
|
<meta name="paf_template" content="" />
|
|
|
|
<!-- TemplateResources meta end -->
|
|
|
|
<!-- Logger begin -->
|
|
<meta name="ncbi_db" content="books" /><meta name="ncbi_pdid" content="book-toc" /><meta name="ncbi_acc" content="NBK566868" /><meta name="ncbi_domain" content="niceng166guid" /><meta name="ncbi_report" content="printable" /><meta name="ncbi_type" content="fulltext" /><meta name="ncbi_objectid" content="" /><meta name="ncbi_pcid" content="/NBK566868/?report=printable" /><meta name="ncbi_app" content="bookshelf" />
|
|
<!-- Logger end -->
|
|
|
|
<title>COVID-19 rapid guideline: severe asthma - NCBI Bookshelf</title>
|
|
|
|
<!-- AppResources external_resources begin -->
|
|
<link rel="stylesheet" href="/core/jig/1.15.2/css/jig.min.css" /><script type="text/javascript" src="/core/jig/1.15.2/js/jig.min.js"></script>
|
|
|
|
<!-- AppResources external_resources end -->
|
|
|
|
<!-- Page meta begin -->
|
|
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE,NOIMAGEINDEX" /><meta name="citation_title" content="COVID-19 rapid guideline: severe asthma" /><meta name="citation_publisher" content="National Institute for Health and Care Excellence (NICE)" /><meta name="citation_date" content="2020/04/03" /><meta name="citation_pmid" content="33497152" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK566868/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="COVID-19 rapid guideline: severe asthma" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute for Health and Care Excellence (NICE)" /><meta name="DC.Date" content="2020/04/03" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK566868/" /><meta name="og:title" content="COVID-19 rapid guideline: severe asthma" /><meta name="og:type" content="book" /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK566868/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng166guid-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/niceng166guid/toc/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK566868/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
|
|
|
|
<!-- Page meta end -->
|
|
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8C65507D7666A100000000012A00F3.m_5" />
|
|
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3985586/3808861/4121862/3974050/3917732/251717/4216701/14534/45193/4113719/3849091/3984811/3751656/4033350/3840896/3577051/3852958/3984801/12930/3964959.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3411343/3882866.css" media="print" /></head>
|
|
<body class="book-toc">
|
|
<div class="grid no_max_width">
|
|
<div class="col twelve_col nomargin shadow">
|
|
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
|
|
<div class="sysmessages">
|
|
<noscript>
|
|
<p class="nojs">
|
|
<strong>Warning:</strong>
|
|
The NCBI web site requires JavaScript to function.
|
|
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
|
</p>
|
|
</noscript>
|
|
</div>
|
|
<!--/.sysmessage-->
|
|
<div class="wrap">
|
|
<div class="page">
|
|
<div class="top">
|
|
|
|
<div class="header">
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<!--<component id="Page" label="headcontent"/>-->
|
|
|
|
</div>
|
|
<div class="content">
|
|
<!-- site messages -->
|
|
<div class="container content">
|
|
<div class="source">
|
|
<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div></div>
|
|
<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="http://www.nice.org.uk/" title="National Institute for Health and Care Excellence (NICE)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng166guid-lrg.png" alt="Cover of COVID-19 rapid guideline: severe asthma" /></a><div class="icnblk_cntnt"><h1 id="_NBK566868_"><span itemprop="name">COVID-19 rapid guideline: severe asthma</span></h1><p><i>NICE Guideline, No. 166</i></p><div class="half_rhythm">London: <a href="http://www.nice.org.uk/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2020 Apr 3</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-3760-8</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2020.</div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div id="cha.s1"><h2 id="_cha_s1_">Overview</h2><p>The purpose of this guideline is to maximise the safety of adults and children with severe asthma during the COVID-19 pandemic, while protecting staff from infection. It will also enable services to make the best use of NHS resources.</p><p>This guideline focuses on what you need to stop or start doing during the pandemic. Follow the usual professional guidelines, standards and laws (including those on equalities, safeguarding, communication and mental capacity), as described in <a href="https://www.nice.org.uk/about/what-we-do/our-programmes/nice-guidance/nice-guidelines/making-decisions-using-nice-guidelines" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">making decisions using NICE guidelines</a>.</p><p>This guideline is for:
|
|
<ul id="cha.l1"><li id="cha.lt1" class="half_rhythm"><div>health and care practitioners</div></li><li id="cha.lt2" class="half_rhythm"><div>health and care staff involved in planning and delivering services</div></li><li id="cha.lt3" class="half_rhythm"><div>commissioners.</div></li></ul></p><p>The recommendations bring together:
|
|
<ul id="cha.l2"><li id="cha.lt4" class="half_rhythm"><div>existing national and international guidance and policies</div></li><li id="cha.lt5" class="half_rhythm"><div>advice from specialists working in the NHS from across the UK. These include people with expertise and experience of treating patients for the specific health conditions covered by the guidance during the current COVID-19 pandemic.</div></li></ul></p><p>NICE has also produced a <a href="https://www.nice.org.uk/guidance/ng174" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COVID-19 rapid guideline: children and young people who are immunocompromised</a>, which should be read alongside this guideline.</p><p>We developed this guideline using the <a href="https://www.nice.org.uk/process/pmg35" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">interim process and methods for developing rapid guidelines on COVID-19</a> in response to the rapidly evolving situation. We will review and update the recommendations as the knowledge base develops using the <a href="https://www.nice.org.uk/process/pmg20/resources/appendix-l-interim-process-and-methods-for-guidelines-developed-in-response-to-health-and-social-care-emergencies-8779776589/chapter/1-introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">interim process and methods for guidelines developed in response to health and social care emergencies</a>.</p><p><b>May 2020:</b> we checked the evidence from the <a href="https://www.medrxiv.org/content/10.1101/2020.05.06.20092999v1" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">OpenSAFELY platform</a> and found no impact on the recommendations in this guideline on using oral corticosteroids for severe asthma.</p></div><div id="cha.s2"><h2 id="_cha_s2_">1. Communicating with patients and minimising risk</h2><dl id="cha.l3" class="temp-labeled-list"><dt>1.1.</dt><dd id="cha.lt6"><p class="no_top_margin">Communicate with patients, their families and carers, and support their mental wellbeing, signposting to charities (such as the <a href="https://www.brit-thoracic.org.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">British Thoracic Society</a>, <a href="https://www.asthma.org.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Asthma UK</a>, and the <a href="https://www.blf.org.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">British Lung Foundation</a>) to help alleviate any anxiety and fear they may have about COVID-19.</p></dd><dt>1.2.</dt><dd id="cha.lt7"><p class="no_top_margin">Be aware that severe asthma is defined by the European Respiratory Society and American Thoracic Society as asthma that requires treatment with high-dose inhaled corticosteroids (see <a href="https://www.nice.org.uk/guidance/ng80/resources/inhaled-corticosteroid-doses-pdf-4731528781" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">inhaled corticosteroid doses for NICE’s asthma guideline</a>) plus a second controller (and/or systemic corticosteroids) to prevent it from becoming ‘uncontrolled’, or which remains ‘uncontrolled’ despite this therapy.</p></dd><dt>1.3.</dt><dd id="cha.lt8"><p class="no_top_margin">Some patients with severe asthma will have received a letter telling them they are at high risk of severe illness from COVID-19. Tell them, or their parent or carer, to follow the advice on shielding in <a href="https://www.gov.uk/government/publications/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">UK government advice on shielding and protecting people defined on medical grounds as extremely vulnerable to COVID-19</a>.</p></dd><dt>1.4.</dt><dd id="cha.lt9"><p class="no_top_margin">Tell all patients, or their parent or carer, to continue taking their regular medicines in line with their personalised asthma action plan. This includes those with COVID-19, or suspected of having it. This is because it’s important that they make sure their asthma is as stable as possible. Ensure their action plan is up to date.</p></dd><dt>1.5.</dt><dd id="cha.lt10"><p class="no_top_margin">Minimise face-to-face contact by:
|
|
<ul id="cha.l4"><li id="cha.lt11" class="half_rhythm"><div>offering telephone, video or email consultations whenever possible</div></li><li id="cha.lt12" class="half_rhythm"><div>cutting non-essential face-to-face appointments</div></li><li id="cha.lt13" class="half_rhythm"><div>contacting patients by text message or email</div></li><li id="cha.lt14" class="half_rhythm"><div>using alternative ways to deliver prescriptions and medicines, such as postal services, NHS volunteers, or drive through pick-up points.</div></li></ul></p></dd><dt>1.6.</dt><dd id="cha.lt15"><p class="no_top_margin">If patients are having a face-to-face appointment, on the day of the appointment first screen them by telephone to make sure they have not developed symptoms of COVID-19.</p></dd><dt>1.7.</dt><dd id="cha.lt16"><p class="no_top_margin">Ask patients to attend appointments with no more than 1 family member or carer, or alone if they can, to reduce the risk of contracting or spreading the infection. If the patient is a child, ask that only 1 adult accompanies them.</p></dd><dt>1.8.</dt><dd id="cha.lt17"><p class="no_top_margin">Minimise time in the waiting area by:
|
|
<ul id="cha.l5"><li id="cha.lt18" class="half_rhythm"><div>careful scheduling</div></li><li id="cha.lt19" class="half_rhythm"><div>encouraging patients not to arrive early</div></li><li id="cha.lt20" class="half_rhythm"><div>texting patients when you are ready to see them, so that they can wait in their car, for example.</div></li></ul></p></dd><dt>1.9.</dt><dd id="cha.lt21"><p class="no_top_margin">When patients with known or suspected COVID-19 have been identified, follow appropriate <a href="https://www.gov.uk/government/publications/wuhan-novel-coronavirus-infection-prevention-and-control" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">UK government guidance on COVID-19: infection prevention and control</a>. This includes recommendations on using personal protective equipment (PPE), patient transfers, transport and options for outpatient settings.</p></dd></dl></div><div id="cha.s3"><h2 id="_cha_s3_">2. Investigations</h2><dl id="cha.l6" class="temp-labeled-list"><dt>2.1.</dt><dd id="cha.lt22"><p class="no_top_margin">Only carry out bronchoscopy and most pulmonary function tests for urgent cases and if the results will have a direct impact on patient care, because these tests have the potential to spread COVID-19. Plan investigations following <a href="https://www.nice.org.uk/guidance/ng179" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NICE’s guideline on arranging planned care in hospitals and diagnostic services</a> or <a href="https://www.gov.uk/government/publications/wuhan-novel-coronavirus-infection-prevention-and-control" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">UK government guidance on infection prevention and control for COVID-19</a> as appropriate. <b>[amended 6 November 2020]</b></p></dd></dl></div><div id="cha.s4"><h2 id="_cha_s4_">3. Treatment</h2><div id="cha.s4.1"><h3>Patients having biological treatment</h3><dl id="cha.l7" class="temp-labeled-list"><dt>3.1.</dt><dd id="cha.lt23"><p class="no_top_margin">Tell patients, or their parent or carer, that they should continue treatment because there is no evidence that biological therapies for asthma suppress immunity.</p></dd><dt>3.2.</dt><dd id="cha.lt24"><p class="no_top_margin">If the patient usually attends hospital to have biological treatments, think about if they can be trained to self-administer, or could be treated at a community clinic or at home.</p></dd><dt>3.3.</dt><dd id="cha.lt25"><p class="no_top_margin">Carry out routine monitoring of biological treatment remotely if possible.</p></dd></dl></div><div id="cha.s4.2"><h3>Patients starting biological treatment</h3><dl id="cha.l8" class="temp-labeled-list"><dt>3.4.</dt><dd id="cha.lt26"><p class="no_top_margin">When patients start on a new biological treatment, balance the risks and benefits of treatment, and take into account <a href="#cha.s6">service modifications</a>.</p></dd><dt>3.5.</dt><dd id="cha.lt27"><p class="no_top_margin">Start treatment even if:
|
|
<ul id="cha.l9"><li id="cha.lt28" class="half_rhythm"><div>you’re not able to assess adherence to regular treatment in the usual way</div></li><li id="cha.lt29" class="half_rhythm"><div>a multidisciplinary team discussion is not possible; 2 senior clinicians in the commissioned service, or delegated by the commissioned service, may make the decision to start biological treatment.</div></li></ul></p></dd><dt>3.6.</dt><dd id="cha.lt30"><p class="no_top_margin">Make sure that:
|
|
<ul id="cha.l10"><li id="cha.lt31" class="half_rhythm"><div>the patient initiation form on Blueteq is completed; for continuation and annual review forms, make sure forms are completed at a future date</div></li><li id="cha.lt32" class="half_rhythm"><div>patient data are added to the registry at the earliest opportunity, after getting patient consent; this can be deferred but, if it is, make arrangements to complete it at a future date.</div></li></ul></p></dd><dt>3.7.</dt><dd id="cha.lt33"><p class="no_top_margin">Have arrangements in place to enable patient self-administration or homecare for subsequent doses, to reduce the need for patients to come into hospital for treatment. Some homecare medicine delivery services are not accepting new referrals, in which case the department would need to organise this.</p></dd></dl></div><div id="cha.s4.3"><h3>Corticosteroids</h3><dl id="cha.l11" class="temp-labeled-list"><dt>3.8.</dt><dd id="cha.lt34"><p class="no_top_margin">Tell patients, or their parent or carer, to continue using inhaled corticosteroids because stopping can increase the risk of asthma exacerbation. Tell them there is no evidence that inhaled corticosteroids increase the risk of getting COVID-19.</p></dd><dt>3.9.</dt><dd id="cha.lt35"><p class="no_top_margin">Tell patients on maintenance oral corticosteroids, or their parent or carer, to continue to take them at their prescribed dose because stopping them can be harmful.</p></dd><dt>3.10.</dt><dd id="cha.lt36"><p class="no_top_margin">Tell patients, or their parent or carer, that if they develop symptoms and signs of an asthma exacerbation, they should follow their personalised asthma action plan and start a course of oral corticosteroids if clinically indicated.</p></dd></dl></div></div><div id="cha.s5"><h2 id="_cha_s5_">4. Equipment</h2><dl id="cha.l12" class="temp-labeled-list"><dt>4.1.</dt><dd id="cha.lt37"><p class="no_top_margin">Tell patients, or their parent or carer, to wash their hands and clean equipment such as face masks, mouth pieces, spacers and peak flow meters regularly using a detergent (for example, washing-up liquid), or to follow the manufacturer’s cleaning instructions.</p></dd><dt>4.2.</dt><dd id="cha.lt38"><p class="no_top_margin">Tell patients, or their parent or carer, not to share their inhalers and devices with anyone else.</p></dd><dt>4.3.</dt><dd id="cha.lt39"><p class="no_top_margin">Tell patients, or their parent or carer, they can continue to use their nebuliser. This is because the aerosol comes from the fluid in the nebuliser chamber and will not carry virus particles from the patient. Find out more from <a href="https://www.gov.uk/government/publications/wuhan-novel-coronavirus-infection-prevention-and-control" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">UK government guidance on COVID-19: infection prevention and control</a>.</p></dd></dl></div><div id="cha.s6"><h2 id="_cha_s6_">5. Modifications to usual care</h2><dl id="cha.l13" class="temp-labeled-list"><dt>5.1.</dt><dd id="cha.lt40"><p class="no_top_margin">Local policies should address modifying usual care at an organisational level.</p></dd><dt>5.2.</dt><dd id="cha.lt41"><p class="no_top_margin">Organise outpatient waiting areas so patients can continue social distancing from other patients and from clinic administrative staff.</p></dd><dt>5.3.</dt><dd id="cha.lt42"><p class="no_top_margin">Prescribe enough asthma medicines to meet the patient’s clinical needs for no more than 30 days’ treatment. For inhalers this depends on the type of inhaler and the number of doses in the inhaler. Prescribing larger quantities of asthma medicines puts the supply chain at risk.</p></dd></dl></div><div id="cha.s7"><h2 id="_cha_s7_">Update information</h2><div id="cha.s7.1"><h3>Minor changes since publication</h3><p><b>6 November 2020:</b> In <a href="#cha.lt22">recommendation 2.1</a>, we linked to the NICE guideline on arranging planned care in hospitals and diagnostic services, and the UK government guidance on infection prevention and control for COVID-19 because NHS England’s guide for managing respiratory patients during the pandemic was withdrawn.</p></div></div><div><p><b>Your responsibility</b>: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals and practitioners are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or the people using their service. It is not mandatory to apply the recommendations, and the guideline does not override the responsibility to make decisions appropriate to the circumstances of the individual, in consultation with them and their families and carers or guardian.</p><p>Local commissioners and providers of healthcare have a responsibility to enable the guideline to be applied when individual professionals and people using services wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with complying with those duties.</p><p>Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should <a href="https://www.nice.org.uk/about/who-we-are/sustainability" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">assess and reduce the environmental impact of implementing NICE recommendations</a> wherever possible.</p></div></div></div>
|
|
<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2020.</div><div class="small"><span class="label">Bookshelf ID: NBK566868</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/33497152" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">33497152</a></span></div></div></div>
|
|
|
|
</div>
|
|
</div>
|
|
</div>
|
|
<div class="bottom">
|
|
|
|
<div id="NCBIFooter_dynamic">
|
|
<!--<component id="Breadcrumbs" label="breadcrumbs"/>
|
|
<component id="Breadcrumbs" label="helpdesk"/>-->
|
|
|
|
</div>
|
|
|
|
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"> </script>
|
|
</div>
|
|
</div>
|
|
<!--/.page-->
|
|
</div>
|
|
<!--/.wrap-->
|
|
</div><!-- /.twelve_col -->
|
|
</div>
|
|
<!-- /.grid -->
|
|
|
|
<span class="PAFAppResources"></span>
|
|
|
|
<!-- BESelector tab -->
|
|
|
|
|
|
|
|
<noscript><img alt="statistics" src="/stat?jsdisabled=true&ncbi_db=books&ncbi_pdid=book-toc&ncbi_acc=NBK566868&ncbi_domain=niceng166guid&ncbi_report=printable&ncbi_type=fulltext&ncbi_objectid=&ncbi_pcid=/NBK566868/?report=printable&ncbi_app=bookshelf" /></noscript>
|
|
|
|
|
|
<!-- usually for JS scripts at page bottom -->
|
|
<!--<component id="PageFixtures" label="styles"></component>-->
|
|
|
|
|
|
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal105 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
|
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
|
|
|
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3879255/4121861/3501987/4008961/3893018/3821238/3400083/3426610.js" snapshot="books"></script></body>
|
|
</html> |