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class="bkr_bib"><h1 id="_NBK561071_"><span itemprop="name">Follow-up after medical abortion up to 10+0 weeks</span></h1><div class="subtitle">Abortion care</div><p><b>Evidence review I</b></p><p><i>NICE Guideline, No. 140</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Guideline Alliance (UK)</span>.</p><div class="half_rhythm">London: <a href="https://www.nice.org.uk" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2019 Sep</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-3539-0</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2019.</div></div><div class="bkr_clear"></div></div><div id="ch9.s1"><h2 id="_ch9_s1_">Follow-up after medical abortion up to 10<sup>+0</sup> weeks</h2><div id="ch9.s1.1"><h3>Review question</h3><p>What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</p><div id="ch9.s1.1.1"><h4>Introduction</h4><p>The aim of this review is to determine the best method of excluding ongoing pregnancy when the expulsion has not been witnessed by healthcare professionals.</p><p>At the time of development, the title of this guideline was ‘Termination of pregnancy’ and this term was used throughout the guideline. In response to comments from stakeholders, the title was changed to ‘Abortion care’ and abortion has been used throughout. Therefore, both terms appear in this evidence report.</p></div><div id="ch9.s1.1.2"><h4>Summary of the protocol</h4><p>See <a class="figpopup" href="/books/NBK561071/table/ch9.tab1/?report=objectonly" target="object" rid-figpopup="figch9tab1" rid-ob="figobch9tab1">Table 1</a> for a summary of the population, intervention, comparison and outcome (PICO) characteristics of this review.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch9tab1"><a href="/books/NBK561071/table/ch9.tab1/?report=objectonly" target="object" title="Table 1" class="img_link icnblk_img figpopup" rid-figpopup="figch9tab1" rid-ob="figobch9tab1"><img class="small-thumb" src="/books/NBK561071/table/ch9.tab1/?report=thumb" src-large="/books/NBK561071/table/ch9.tab1/?report=previmg" alt="Table 1. Summary of the protocol (PICO table)." /></a><div class="icnblk_cntnt"><h4 id="ch9.tab1"><a href="/books/NBK561071/table/ch9.tab1/?report=objectonly" target="object" rid-ob="figobch9tab1">Table 1</a></h4><p class="float-caption no_bottom_margin">Summary of the protocol (PICO table). </p></div></div><p>For further details see the full review protocol in <a href="#ch9.appa">appendix A</a>.</p></div><div id="ch9.s1.1.3"><h4>Clinical evidence</h4><div id="ch9.s1.1.3.1"><h5>Included studies</h5><p>Only studies conducted from 2000 onwards were considered for this review question, because after 2000 clinical practice changed to include the possibility of remote assessment for successful abortion of an early pregnancy when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home).</p><p>Six randomised controlled trials were included in this evidence review. Four of these studies compared routine clinic-based follow-up with remote, home-based, self-assessment follow-up after medical abortion (<a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>; <a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>; <a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>; <a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>) while the remaining 2 studies compared different methods of remote, home-based self-assessment follow-up (<a class="bibr" href="#ch9.s1.1.ref1" rid="ch9.s1.1.ref1">Blum 2016</a>; <a class="bibr" href="#ch9.s1.1.ref3" rid="ch9.s1.1.ref3">Constant 2017</a>).</p><p>The included studies are summarised in <a class="figpopup" href="/books/NBK561071/table/ch9.tab2/?report=objectonly" target="object" rid-figpopup="figch9tab2" rid-ob="figobch9tab2">Table 2</a>.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch9tab2"><a href="/books/NBK561071/table/ch9.tab2/?report=objectonly" target="object" title="Table 2" class="img_link icnblk_img figpopup" rid-figpopup="figch9tab2" rid-ob="figobch9tab2"><img class="small-thumb" src="/books/NBK561071/table/ch9.tab2/?report=thumb" src-large="/books/NBK561071/table/ch9.tab2/?report=previmg" alt="Table 2. Summary of included studies." /></a><div class="icnblk_cntnt"><h4 id="ch9.tab2"><a href="/books/NBK561071/table/ch9.tab2/?report=objectonly" target="object" rid-ob="figobch9tab2">Table 2</a></h4><p class="float-caption no_bottom_margin">Summary of included studies. </p></div></div><p>See the literature search strategy in <a href="#ch9.appb">appendix B</a> and study selection flow chart in <a href="#ch9.appc">appendix C</a>.</p></div><div id="ch9.s1.1.3.2"><h5>Excluded studies</h5><p>Studies not included in this review with reasons for their exclusions are provided in <a href="#ch9.appk">appendix K</a>.</p></div></div><div id="ch9.s1.1.4"><h4>Summary of clinical studies included in the evidence review</h4><p>A summary of the studies that were included in this review are presented in <a class="figpopup" href="/books/NBK561071/table/ch9.tab2/?report=objectonly" target="object" rid-figpopup="figch9tab2" rid-ob="figobch9tab2">Table 2</a>.</p><p>See the full evidence tables in <a href="#ch9.appd">appendix D</a> and the forest plots in <a href="#ch9.appe">appendix E</a>.</p></div><div id="ch9.s1.1.5"><h4>Quality assessment of clinical studies included in the evidence review</h4><p>See the clinical evidence profiles in <a href="#ch9.appf">appendix F</a>.</p></div><div id="ch9.s1.1.6"><h4>Economic evidence</h4><div id="ch9.s1.1.6.1"><h5>Included studies</h5><p>A systematic review of the economic literature was conducted but no economic studies were identified which were applicable to this review question.</p><p>A single economic search was undertaken for all topics included in the scope of this guideline. Please see <a href="/books/NBK561071/bin/bm2.pdf">supplementary material 2</a> for details.</p></div><div id="ch9.s1.1.6.2"><h5>Excluded studies</h5><p>No full-text copies of articles were requested for this review and so there is no excluded studies list.</p></div></div><div id="ch9.s1.1.7"><h4>Economic model</h4><p>No economic modelling was undertaken for this review because the committee agreed that other topics were higher priorities for economic evaluation.</p></div><div id="ch9.s1.1.8"><h4>Resource impact</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch9tab3"><a href="/books/NBK561071/table/ch9.tab3/?report=objectonly" target="object" title="Table 3" class="img_link icnblk_img figpopup" rid-figpopup="figch9tab3" rid-ob="figobch9tab3"><img class="small-thumb" src="/books/NBK561071/table/ch9.tab3/?report=thumb" src-large="/books/NBK561071/table/ch9.tab3/?report=previmg" alt="Table 3. Unit costs of pregnancy tests considered." /></a><div class="icnblk_cntnt"><h4 id="ch9.tab3"><a href="/books/NBK561071/table/ch9.tab3/?report=objectonly" target="object" rid-ob="figobch9tab3">Table 3</a></h4><p class="float-caption no_bottom_margin">Unit costs of pregnancy tests considered. </p></div></div></div><div id="ch9.s1.1.9"><h4>Evidence statements</h4></div><div id="ch9.s1.1.10"><h4>Comparison 1. Remote follow-up versus clinic follow-up</h4><div id="ch9.s1.1.10.1"><h5>Critical outcomes</h5><div id="ch9.s1.1.10.1.1"><h5>Missed ongoing pregnancy (failure to detect an ongoing pregnancy)</h5><p>RCT evidence (n=2935) did not detect a clinically important difference in ‘the rate of missed ongoing pregnancy’ between the remote follow-up group and the clinic-based follow-up group (3 RCTs, n=2935; RR= 4.91; 95% CI 0.58, 41.54; very low quality); however, there was uncertainty around this estimate.</p></div><div id="ch9.s1.1.10.1.2"><h5>Correct implementation of follow-up strategy (comprehension; i.e., the women understand how to undertake the remote self-assessment protocol)</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch9.s1.1.10.1.3"><h5>Patient satisfaction (prefer remote follow-up for managing abortion follow-up in future)</h5><p>RCT evidence that could not be meta-analysed due to high heterogeneity (I<sup>2</sup>=99%; 4 RCTs, n=5060; very low quality) showed a higher clinically important difference in the rates of women who preferred remote follow-up for managing abortion in the future in the women who received remote follow-up compared to the women who received clinic-based follow-up in 3 of the 4 studies (RR=1.4, 95% CI 1.26, 1.55; RR=1.58; 95% CI 1.48, 1.69; and RR=2.22; 95% CI 2.01, 2.45, respectively) whereas there was no clinically important difference in the 4<sup>th</sup> study (RR=1.03; 95% CI 0.96, 1.1).</p></div></div><div id="ch9.s1.1.10.2"><h5>Important outcomes</h5><div id="ch9.s1.1.10.2.1"><h5>Adherence to follow-up strategy</h5><p>RCT evidence that could not be meta-analysed due to high heterogeneity (I<sup>2</sup>=93%; 3 RCTs, n=4766; very low quality) showed no clinically important difference in ‘the rates of adherence to the follow-up strategy’ between women who received remote or clinic-based follow-up (RR=0.95, 95% CI 0.87, 1.03; RR=0.99; 95% CI 0.98, 1.01; and RR=1.07; 95% CI 1.05, 1.1, respectively).</p></div><div id="ch9.s1.1.10.2.2"><h5>Unscheduled visits to the abortion service</h5><p>RCT evidence did not detect a clinically important difference in ‘the rate of unscheduled visits to the abortion service’ between the remote follow-up group and the clinic-based follow-up group (4 RCTs, n=5454; RR= 1.2; 95% CI 0.91, 1.59; low quality); however, there was uncertainty around this estimate.</p></div><div id="ch9.s1.1.10.2.3"><h5>Unscheduled phone calls to the abortion service</h5><p>RCT evidence did not detect a clinically important difference in ‘the rate of unscheduled telephone calls to the abortion service’ between the remote follow-up group and the clinic-based follow-up group (1 RCT, n=694; RR= 1.05; 95% CI 0.78, 1.43; very low quality); however, there was uncertainty around this estimate.</p></div><div id="ch9.s1.1.10.2.4"><h5>Surgical intervention</h5><p>RCT evidence did not detect a clinically important difference in ‘the rate of surgical intervention’ between the remote follow-up group and the clinic-based follow-up group (4 RCTs, n=5703; RR= 0.93; 95% CI 0.7, 1.23; very low quality); however, there was uncertainty around this estimate.</p></div></div></div><div id="ch9.s1.1.11"><h4>Comparison 2. Remote follow-up ‘Multi-level pregnancy test’ versus remote follow-up ‘High sensitivity pregnancy test’</h4><div id="ch9.s1.1.11.1"><h5>Critical outcomes</h5><div id="ch9.s1.1.11.1.1"><h5>Missed ongoing pregnancy (failure to detect an ongoing pregnancy)</h5><p>RCT evidence reported no events of missed ongoing pregnancy in either the multi-level pregnancy test group or the high sensitivity pregnancy test group; therefore difference between groups could not be estimate (1 RCT, n=584; low quality).</p></div><div id="ch9.s1.1.11.1.2"><h5>Correct implementation of follow-up strategy (comprehension; i.e., the women understand how to undertake the remote self-assessment protocol)</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch9.s1.1.11.1.3"><h5>Patient satisfaction (prefer remote follow-up for managing abortion follow-up in future)</h5><p>RCT evidence showed no clinically important difference in ‘the rate of women who preferred remote follow-up for managing abortion in the future’ between the multi-level pregnancy test group and the high sensitivity pregnancy test group (1 RCT, n=584; RR=0.97; 95% CI 0.92, 1.03; moderate quality).</p></div></div><div id="ch9.s1.1.11.2"><h5>Important outcomes</h5><div id="ch9.s1.1.11.2.1"><h5>Adherence to follow-up strategy</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch9.s1.1.11.2.2"><h5>Unscheduled visits to the abortion service</h5><p>RCT evidence showed a lower clinically important difference in ‘the rate of unscheduled visits to the abortion service’ in the multi-level pregnancy test group compared with the high sensitivity pregnancy test group (1 RCT, n=584; RR= 0.09; 95% CI 0.04, 0.22; moderate quality).</p></div><div id="ch9.s1.1.11.2.3"><h5>Unscheduled phone calls to the abortion service</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch9.s1.1.11.2.4"><h5>Surgical intervention</h5><p>RCT evidence did not detect a clinically important difference in ‘the rate of surgical intervention’ between the multi-level pregnancy test group and the high sensitivity pregnancy test group (1 RCT, n=584; RR= 0.33; 95% CI 0.01, 8.09; very low quality); however, there was uncertainty around this estimate.</p></div></div></div><div id="ch9.s1.1.12"><h4>Comparison 3. Remote follow-up ‘Demonstration’ versus remote follow-up ‘Instruction’</h4><div id="ch9.s1.1.12.1"><h5>Critical outcomes</h5><div id="ch9.s1.1.12.1.1"><h5>Missed ongoing pregnancy (failure to detect an ongoing pregnancy)</h5><p>RCT evidence did not detect a clinically important difference in ‘the rate of missed ongoing pregnancy’ between the Demonstration group and the Instruction group (1 RCT, n=426; RR=2.86; 95% CI 0.12, 69.89; very low quality); however, there was uncertainty around this estimate.</p></div><div id="ch9.s1.1.12.1.2"><h5>Correct implementation of follow-up strategy (comprehension; i.e., the women understand how to undertake the remote self-assessment protocol)</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch9.s1.1.12.1.3"><h5>Patient satisfaction (prefer remote follow-up for managing abortion follow-up in future)</h5><p>RCT evidence showed no clinically important difference in ‘the rate of women who preferred remote follow-up for managing abortion in the future’ between the Demonstration group and the Instruction group (1 RCT, n=458; RR=1; 95% CI 0.98, 1.03; moderate quality).</p></div></div><div id="ch9.s1.1.12.2"><h5>Important outcomes</h5><div id="ch9.s1.1.12.2.1"><h5>Adherence to follow-up strategy</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch9.s1.1.12.2.2"><h5>Unscheduled visits to the abortion service</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch9.s1.1.12.2.3"><h5>Unscheduled phone calls to the abortion service</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch9.s1.1.12.2.4"><h5>Surgical intervention</h5><p>No evidence was identified to inform this outcome.</p></div></div></div><div id="ch9.s1.1.13"><h4>The committee’s discussion of the evidence</h4><div id="ch9.s1.1.13.1"><h5>Interpreting the evidence</h5><div id="ch9.s1.1.13.1.1"><h5>The outcomes that matter most</h5><p>Verification of the success of an early medical abortion usually involves a follow-up in-person ultrasound scan. However, women could assess the success of the procedure remotely themselves by following a remote assessment protocol including a urine pregnancy test, provided the remote protocol is as effective and safe as in-person assessment. Missed on-going pregnancy, correct implementation of follow-up strategy and patient satisfaction were therefore selected as critical outcomes. Adherence to follow-up strategy, unscheduled visits or telephone calls to the abortion service and surgical intervention were included as important outcomes due to the impact that needing an unscheduled or second appointment will have on both the woman and on available resources.</p></div><div id="ch9.s1.1.13.1.2"><h5>The quality of the evidence</h5><p>The evidence in the pairwise comparisons was assessed using the GRADE methodology. The quality of the evidence across all outcomes ranged from very low to moderate quality and was most often downgraded due to imprecision, inconsistency or design limitations, e.g., 5 of the 6 studies were unblinded.</p></div><div id="ch9.s1.1.13.1.3"><h5>Benefits and harms</h5><p>The evidence showed that there were no clinically important differences in the rate of adherence to follow-up strategy between the remote and clinic-based follow-up groups, and that is was unclear whether or not there were clinically important differences between these groups in the rates of missed ongoing pregnancy, unscheduled phone calls or visits to the abortion service or surgical intervention. The evidence also showed that in 3 of the 4 studies the women in the remote follow up groups expressed a clinically important higher rate of preference for remote follow up in a potential future abortion than in the clinic-based groups. When comparing different remote follow-up strategies, the evidence showed that there were no clinically important differences between these comparisons in terms of patient preference, but for both comparisons it was unclear whether or not there was a clinically important difference in the rates of missed ongoing pregnancy, and this was also the case for rates of surgical intervention for the multi-level urine pregnancy test versus a high sensitivity urine pregnancy test comparison. There was, however, a higher clinically important difference in the rate of unscheduled visits to the abortion service in the high-sensitivity urine pregnancy group compared to the multi-level urine pregnancy test group.</p><p>The committee noted that both in the evidence and in their experience many women do not return to clinic for their follow-up appointment. A potential benefit of these recommendations is therefore that by giving women both the choice of follow-up method and, in the case of self-assessment and remote follow-up, a pregnancy test, overall more women will receive follow-up. This in turn will help ensure that any unsuccessful medical abortions will have a higher chance of being identified earlier. Moreover, the committee noted that women have to wait longer after the abortion procedure in order to be able to use high sensitivity pregnancy tests because these are not reliable as soon after the abortion as other pregnancy tests. This means that the recommendations will also serve to ensure a quicker resolution of the whole medical abortion intervention. Overall, the committee therefore agreed that the recommendations serve to make abortion services more women-centred by focusing on women’s preference for follow-up method and swift resolution in terms of the assessment of the outcome of the abortion.</p><p>As there was sufficient evidence to inform the recommendations, the committee decided to prioritise other areas addressed by the guideline for future research and therefore made no research recommendations regarding the best method of excluding an ongoing pregnancy after early (up to and including 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home).</p></div></div><div id="ch9.s1.1.13.2"><h5>Cost effectiveness and resource use</h5><p>A systematic review of the economic literature was conducted but no relevant studies were identified which were applicable to this review question.</p><p>The committee considered that there was unlikely to be a significant resource impact from the recommendations made. Any net effect was likely to be cost saving due to fewer clinic visits and fewer ultrasound scans being required for women opting for self-assessment or remote follow-up rather than in-clinic follow-up. Moreover, although low sensitive pregnancy tests are more expensive than high sensitivity pregnancy tests, this difference in price will be offset by fewer clinic visits (and fewer false positive test results) by women who receive the low sensitivity pregnancy test compared to the high sensitivity pregnancy test.</p></div></div><div id="ch9.rl.r1"><h4>References</h4><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch9.s1.1.ref1"><p id="p-140">
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<strong>Blum 2016</strong>
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</p>Blum, J., Sheldon, W. R., Ngoc, N. T. N., Winikoff, B., Nga, N. T. B., Martin, R., Van Thanh, L., Blumenthal, P. D., Randomized trial assessing home use of two pregnancy tests for determining early medical abortion outcomes at 3, 7 and 14 days after mifepristone, Contraception, 94, 115–121, 2016 [<a href="https://pubmed.ncbi.nlm.nih.gov/27067706" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27067706</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch9.s1.1.ref2"><p id="p-141">
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<strong>Bracken 2014</strong>
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</p>Bracken, H., Lohr, P. A., Taylor, J., Morroni, C., Winikoff, B., RU OK? The acceptability and feasibility of remote technologies for follow-up after early medical abortion, Contraception, 90, 29–35, 2014 [<a href="https://pubmed.ncbi.nlm.nih.gov/24815098" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24815098</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch9.s1.1.ref3"><p id="p-142">
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<strong>Constant 2017</strong>
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</p>Constant, D., Harries, J., Daskilewicz, K., Myer, L., Gemzell-Danielsson, K., Is self-assessment of medical abortion using a low-sensitivity pregnancy test combined with a checklist and phone text messages feasible in South African primary healthcare settings? A randomized trial, PLoS ONE, 12 (6) (no pagination), 2017 [<a href="/pmc/articles/PMC5480887/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5480887</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28640845" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28640845</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch9.s1.1.ref4"><p id="p-143">
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<strong>Ngoc 2014</strong>
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</p>Ngoc, N. T. N., Bracken, H., Blum, J., Nga, N. T. B., Minh, N. H., Van Nhang, N., Lynd, K., Winikoff, B., Blumenthal, P. D., Acceptability and feasibility of phone follow-up after early medical abortion in Vietnam: A randomized controlled trial, Obstetrics and gynecology, 123, 88–95, 2014 [<a href="https://pubmed.ncbi.nlm.nih.gov/24463668" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24463668</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch9.s1.1.ref5"><p id="p-144">
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<strong>Oppegaard 2015</strong>
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</p>Oppegaard, K. S., Qvigstad, E., Fiala, C., Heikinheimo, O., Benson, L., Gemzell-Danielsson, K., Clinical follow-up compared with self-assessment of outcome after medical abortion: A multicentre, non-inferiority, randomised, controlled trial, The Lancet, 385, 698–704, 2015 [<a href="https://pubmed.ncbi.nlm.nih.gov/25468164" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25468164</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch9.s1.1.ref6"><p id="p-145">
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<strong>Platais 2015</strong>
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</p>Platais, I., Tsereteli, T., Comendant, R., Kurbanbekova, D., Winikoff, B., Acceptability and feasibility of phone follow-up with a semiquantitative urine pregnancy test after medical abortion in Moldova and Uzbekistan, Contraception, 91, 178–183, 2015 [<a href="https://pubmed.ncbi.nlm.nih.gov/25497383" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25497383</span></a>]</div></p></li></ul></div></div></div><div id="appendixesappgroup9"><h2 id="_appendixesappgroup9_">Appendices</h2><div id="ch9.appa"><h3>Appendix A. Review protocols</h3><div id="ch9.appa.s1"><h4>Review protocol for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch9appatab1"><a href="/books/NBK561071/table/ch9.appa.tab1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch9appatab1" rid-ob="figobch9appatab1"><img class="small-thumb" src="/books/NBK561071/table/ch9.appa.tab1/?report=thumb" src-large="/books/NBK561071/table/ch9.appa.tab1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch9.appa.tab1"><a href="/books/NBK561071/table/ch9.appa.tab1/?report=objectonly" target="object" rid-ob="figobch9appatab1">Table</a></h4><p class="float-caption no_bottom_margin">Women who have had a medical termination of pregnancy (up to 10<sup>+0</sup> weeks of gestation) with mifepristone and misoprostol and expelled the pregnancy at home Exclusions:
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-No studies with indirect populations</p></div></div></div></div><div id="ch9.appb"><h3>Appendix B. Literature search strategies</h3><div id="ch9.appb.s1"><h4>Literature search strategy for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><p>The search for this topic was last run on 19<sup>th</sup> November 2018 during the re-runs for this guideline.</p><p>
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<b>Database: Medline & Embase (Multifile)</b>
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</p><p>Last searched on <b>Embase Classic+Embase</b> 1947 to 2018 November 16, <b>Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R)</b> 1946 to November 16, 2018</p><p id="ch9.appb.tab1"><a href="/books/NBK561071/table/ch9.appb.tab1/?report=objectonly" target="object" rid-ob="figobch9appbtab1" class="figpopup">Date of last search: 19<sup>th</sup> November 2018</a></p><p>
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<b>Database: Cochrane Library via Wiley Online</b>
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</p><p id="ch9.appb.tab2"><a href="/books/NBK561071/table/ch9.appb.tab2/?report=objectonly" target="object" rid-ob="figobch9appbtab2" class="figpopup">Date of last search: 19<sup>th</sup> November 2018</a></p></div></div><div id="ch9.appc"><h3>Appendix C. Clinical evidence study selection</h3><div id="ch9.appc.s1"><h4>Clinical evidence study selection for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><p id="ch9.appc.fig1"><a href="/books/NBK561071/figure/ch9.appc.fig1/?report=objectonly" target="object" rid-ob="figobch9appcfig1" class="figpopup">Figure 1. Study selection flow chart</a></p></div></div><div id="ch9.appd"><h3>Appendix D. Clinical evidence tables</h3><div id="ch9.appd.s1"><h4>Clinical evidence tables for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><p id="ch9.appd.et1"><a href="/books/NBK561071/bin/ch9-appd-et1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Download PDF</a><span class="small"> (429K)</span></p></div></div><div id="ch9.appe"><h3>Appendix E. Forest plots</h3><div id="ch9.appe.s1"><h4>Forest plots for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><div id="ch9.appe.s1.1"><h5>Comparison 1. Remote follow-up versus clinic follow-up</h5><p id="ch9.appe.fig1"><a href="/books/NBK561071/figure/ch9.appe.fig1/?report=objectonly" target="object" rid-ob="figobch9appefig1" class="figpopup">Figure 2. Missed ongoing pregnancy</a></p><p id="ch9.appe.fig2"><a href="/books/NBK561071/figure/ch9.appe.fig2/?report=objectonly" target="object" rid-ob="figobch9appefig2" class="figpopup">Figure 3. Patient satisfaction (Prefer remote follow up for managing abortion follow up in the future) <i>Not meta-analysed due to high heterogeneity (I<sup>2</sup> = 99%)</i></a></p><p id="ch9.appe.fig3"><a href="/books/NBK561071/figure/ch9.appe.fig3/?report=objectonly" target="object" rid-ob="figobch9appefig3" class="figpopup">Figure 4. Adherence to follow-up strategy; Not meta-analysed due to high heterogeneity (I<sup>2</sup> = 93%)</a></p><p id="ch9.appe.fig4"><a href="/books/NBK561071/figure/ch9.appe.fig4/?report=objectonly" target="object" rid-ob="figobch9appefig4" class="figpopup">Figure 5. Unscheduled visits to the abortion service</a></p><p id="ch9.appe.fig5"><a href="/books/NBK561071/figure/ch9.appe.fig5/?report=objectonly" target="object" rid-ob="figobch9appefig5" class="figpopup">Figure 6. Surgical intervention</a></p></div></div></div><div id="ch9.appf"><h3>Appendix F. GRADE tables</h3><div id="ch9.appf.s1"><h4>GRADE tables for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><p id="ch9.appf.tab1"><a href="/books/NBK561071/table/ch9.appf.tab1/?report=objectonly" target="object" rid-ob="figobch9appftab1" class="figpopup">Table 4. Clinical evidence profile: Comparison 1. Remote follow-up versus clinic follow-up</a></p><p id="ch9.appf.tab2"><a href="/books/NBK561071/table/ch9.appf.tab2/?report=objectonly" target="object" rid-ob="figobch9appftab2" class="figpopup">Table 5. Clinical evidence profile: Comparison 2. Remote follow-up ‘Multi-level pregnancy test’ versus remote follow-up ‘High sensitivity pregnancy test’</a></p><p id="ch9.appf.tab3"><a href="/books/NBK561071/table/ch9.appf.tab3/?report=objectonly" target="object" rid-ob="figobch9appftab3" class="figpopup">Table 6. Clinical evidence profile: Comparison 3. Remote follow-up ‘Demonstration’ versus remote follow-up ‘Instruction’</a></p></div></div><div id="ch9.appg"><h3>Appendix G. Economic evidence study selection</h3><div id="ch9.appg.s1"><h4>Economic evidence for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><p>No economic evidence was identified which was applicable to this review question.</p></div></div><div id="ch9.apph"><h3>Appendix H. Economic evidence tables</h3><div id="ch9.apph.s1"><h4>Economic evidence tables for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><p>No economic evidence was identified which was applicable to this review question.</p></div></div><div id="ch9.appi"><h3>Appendix I. Economic evidence profiles</h3><div id="ch9.appi.s1"><h4>Economic evidence profiles for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><p>No economic evidence was identified which was applicable to this review question.</p></div></div><div id="ch9.appj"><h3>Appendix J. Health economic analysis</h3><div id="ch9.appj.s1"><h4>Economic analysis for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home?</h4><p>No economic analysis was conducted for this review question.</p></div></div><div id="ch9.appk"><h3>Appendix K. Excluded studies</h3><div id="ch9.appk.s1"><h4>Excluded studies for review question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4></div><div id="ch9.appk.s2"><h4>Clinical studies</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch9appktab1"><a href="/books/NBK561071/table/ch9.appk.tab1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch9appktab1" rid-ob="figobch9appktab1"><img class="small-thumb" src="/books/NBK561071/table/ch9.appk.tab1/?report=thumb" src-large="/books/NBK561071/table/ch9.appk.tab1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch9.appk.tab1"><a href="/books/NBK561071/table/ch9.appk.tab1/?report=objectonly" target="object" rid-ob="figobch9appktab1">Table</a></h4><p class="float-caption no_bottom_margin">PICO: population, intervention, comparison and outcomes </p></div></div></div><div id="ch9.appk.s3"><h4>Economic studies</h4><p>No economic evidence was identified for this review. See <a href="/books/NBK561071/bin/bm2.pdf">supplementary material 2</a> for further information.</p></div></div><div id="ch9.appl"><h3>Appendix L. Research recommendations</h3><div id="ch9.appl.s1"><h4>Research recommendations for question: What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical abortion, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</h4><p>No research recommendations were made for this review question.</p></div></div></div></div><div class="fm-sec"><div><p>Final</p></div><div><p>Evidence reviews</p><p>These evidence reviews were developed by the National Guideline Alliance hosted by the Royal College of Obstetricians and Gynaecologists</p></div><div><p><b>Disclaimer</b>: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.</p><p>Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.</p><p>NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the <a href="http://wales.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Welsh Government</a>, <a href="http://www.scotland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Scottish Government</a>, and <a href="http://www.northernireland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Northern Ireland Executive</a>. All NICE guidance is subject to regular review and may be updated or withdrawn.</p></div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2019.</div><div class="small"><span class="label">Bookshelf ID: NBK561071</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32813469" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">32813469</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article><article data-type="table-wrap" id="figobch9tab1"><div id="ch9.tab1" class="table"><h3><span class="label">Table 1</span><span class="title">Summary of the protocol (PICO table)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.tab1_lrgtbl__"><table class="no_bottom_margin"><tbody><tr><th id="hd_b_ch9.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><td headers="hd_b_ch9.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Women who have had a medical termination of pregnancy (up to 10<sup>+0</sup> weeks of gestation) with mifepristone and misoprostol and expelled the pregnancy at home</td></tr><tr><th id="hd_b_ch9.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention</th><td headers="hd_b_ch9.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="l370"><li id="lt932" class="half_rhythm"><div>In-person assessment with an ultrasound scan (not keeping women in to check the expulsion)</div></li><li id="lt933" class="half_rhythm"><div>Remote assessment (e.g., consisting of low sensitivity urine pregnancy test, high sensitivity urine pregnancy test, multilevel urine pregnancy test, serum human chorionic gonadotropin (HCG), and/or self-assessment check lists)</div></li></ul>
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</td></tr><tr><th id="hd_b_ch9.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparison</th><td headers="hd_b_ch9.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="l371"><li id="lt934" class="half_rhythm"><div>In-person assessment versus remote assessment</div></li><li id="lt935" class="half_rhythm"><div>Remote assessment protocol 1 versus remote assessment protocol 2</div></li></ul>
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</td></tr><tr><th id="hd_b_ch9.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcome</th><td headers="hd_b_ch9.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Critical outcomes:</b>
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<ul id="l372"><li id="lt936" class="half_rhythm"><div>Missed ongoing pregnancy (failure to detect an ongoing pregnancy)</div></li><li id="lt937" class="half_rhythm"><div>Correct implementation of follow-up strategy (comprehension; i.e., the women understand how to undertake the remote self-assessment protocol)</div></li><li id="lt938" class="half_rhythm"><div>Patient satisfaction</div></li></ul>
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<b>Important outcomes:</b>
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<ul id="l373"><li id="lt939" class="half_rhythm"><div>Adherence to follow-up strategy</div></li><li id="lt940" class="half_rhythm"><div>Unscheduled visits or telephone calls to the termination service</div></li><li id="lt941" class="half_rhythm"><div>Surgical intervention</div></li></ul></td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">HCG: human chorionic gonadotropin</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch9tab2"><div id="ch9.tab2" class="table"><h3><span class="label">Table 2</span><span class="title">Summary of included studies</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch9.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study and setting</th><th id="hd_h_ch9.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><th id="hd_h_ch9.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention/ comparison</th><th id="hd_h_ch9.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes</th></tr></thead><tbody><tr><td headers="hd_h_ch9.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>
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<a class="bibr" href="#ch9.s1.1.ref1" rid="ch9.s1.1.ref1">Blum 2016</a>
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</p>
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<p>Randomised controlled trial</p>
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<p>Vietnam</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>n=600</p>
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<p>Literate women seeking early medical abortion with gestational age ≤63 days</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><b>Medical abortion:</b> 200mg mifepristone followed by 800micrograms (mcg) buccal misoprostol the next day.</p>
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<p><b>Home-based follow-up:</b> Multilevel pregnancy test at 3, 7 and 14 days after mifepristone.</p>
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<p><b>Home based follow up:</b> High sensitivity pregnancy test at 3, 7 and 14 days after mifepristone.</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="l374"><li id="lt942" class="half_rhythm"><div>Missed ongoing pregnancy</div></li><li id="lt943" class="half_rhythm"><div>Patient satisfaction</div></li><li id="lt944" class="half_rhythm"><div>Unscheduled visits to the abortion service</div></li><li id="lt945" class="half_rhythm"><div>Surgical intervention</div></li></ul>
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</td></tr><tr><td headers="hd_h_ch9.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>
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<a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>
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</p>
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<p>Randomised controlled trial</p>
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<p>England</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>n=999</p>
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<p>Women aged 16 years or above requesting a medical abortion using mifepristone and misoprostol for a pregnancy ≤63 days gestation by ultrasound scan</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><b>Medical abortion:</b> 200mg oral mifepristone followed by 800mcg vaginal misoprostol 6-72 hours later in the clinic.</p>
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<p><b>Routine clinical follow-up (Clinic):</b> In-clinic US and assessment of outcome of abortion 1 week later. Women in this group were also provided with a high-sensitivity urine pregnancy test to take 3 weeks later and to phone the clinic with the results in case of being unable to attend their in-person visit.</p>
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<p><b>Self-assessment (Remote):</b> Women choose between a telephone call, SMS text message or online questionnaire as their preferred method of remote follow-up, and they were given a low sensitivity pregnancy test to take 2 weeks later when they were also asked a series of questions about potential symptoms via their indicated method.</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="l375"><li id="lt946" class="half_rhythm"><div>Missed ongoing pregnancy</div></li><li id="lt947" class="half_rhythm"><div>Patient satisfaction</div></li><li id="lt948" class="half_rhythm"><div>Adherence to follow-up strategy</div></li><li id="lt949" class="half_rhythm"><div>Unscheduled visits to the abortion service</div></li><li id="lt950" class="half_rhythm"><div>Surgical intervention</div></li></ul>
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</td></tr><tr><td headers="hd_h_ch9.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>
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<a class="bibr" href="#ch9.s1.1.ref3" rid="ch9.s1.1.ref3">Constant 2017</a>
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</p>
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<p>Randomised controlled trial</p>
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<p>South Africa</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>n=525</p>
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<p>Women aged 18 years or above, requesting and clinically eligible for medical abortion using mifepristone with home-use of misoprostol of a pregnancy with a gestation up to 63 days.</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><b>Medical abortion:</b> 200mg oral mifepristone followed by 800mcg buccal/sublingual misoprostol 24 to 48 hours later.</p>
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<p><b>Home-based follow-up - Demonstration</b>: In-clinic practice of conducting and interpreting (5 min later) a low-sensitivity pregnancy test on own urine sample and interpreted the result at 5 minutes with guidance provided by a study fieldworker using a standardized procedure and pre-scripted instructions. Women then given a symptom checklist and a low sensitivity pregnancy test kit to use on first morning urine 14 days after mifepristone.</p>
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<p><b>Home-based follow-up - Instruction</b>: Same pre-scripted verbal instructions were provided as for Demonstration group, but no practice demonstration. Women then given a symptom checklist and a low-sensitivity pregnancy test kit to use on first morning urine 14 days after mifepristone.</p>
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<p>Both group assessed in clinic 2 weeks later.</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="l376"><li id="lt951" class="half_rhythm"><div>Missed ongoing pregnancy</div></li><li id="lt952" class="half_rhythm"><div>Patient satisfaction</div></li></ul>
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</td></tr><tr><td headers="hd_h_ch9.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>
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<a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>
|
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</p>
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<p>Randomised controlled trial</p>
|
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<p>Vietnam</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>n=1433</p>
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<p>Women requesting medical abortion of an intrauterine pregnancy up to 63 days gestation with a working personal phone and no known contraindications to abortion with mifepristone and/or misoprostol, who were able to complete an at-home symptom checklist</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><b>Medical abortion:</b> “The most common treatment regimen used for early medical abortion services at the [4] hospitals consists of oral 200 mg mifepristone followed in 24–48 hours by 800micrograms buccal misoprostol administered at home.” (p. 89)</p>
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<p><b>Clinic follow-up (Clinic):</b> Clinic visit 2 weeks after mifepristone administration for a clinical assessment and transvaginal US to confirm the abortion outcome.</p>
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<p><b>Remote follow-up (Remote):</b> A urine-based semi-quantitative pregnancy test, a urine sample cup, an information sheet explaining how to perform and interpret the test, and a questionnaire (which had the woman’s baseline human chorionic gonadotropin (hCG) noted on it) to use at home before a scheduled phone-based follow-up appointment 2 weeks after mifepristone administration.</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="l377"><li id="lt953" class="half_rhythm"><div>Missed ongoing pregnancy</div></li><li id="lt954" class="half_rhythm"><div>Patient satisfaction</div></li><li id="lt955" class="half_rhythm"><div>Adherence to follow-up strategy</div></li><li id="lt956" class="half_rhythm"><div>Unscheduled visits to the abortion service</div></li><li id="lt957" class="half_rhythm"><div>Surgical intervention</div></li></ul>
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</td></tr><tr><td headers="hd_h_ch9.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>
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<a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>
|
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</p>
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<p>Randomised controlled trial</p>
|
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<p>Austria, Finland, Norway and Sweden</p>
|
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</td><td headers="hd_h_ch9.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>n=929</p>
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<p>Women aged 18 years or above requesting a medical abortion of a confirmed evolutive intrauterine pregnancy (visible intrauterine yolk sac or fetal heartbeat on US) of up to 63 days’ gestation.</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><b>Medical abortion:</b> 200mg mifepristone followed by 800mcg vaginal misoprostol 24 to 48 hours later at home.</p>
|
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<p><b>Routine clinical follow-up (Clinic):</b> In-clinic assessment of outcome of abortion 1 to 3 weeks later by a low-sensitivity urine hCG test, measurement of hCG in serum, or ultrasonography.</p>
|
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<p><b>Self-assessment (Remote):</b> Self-administration of a 2-step urine hCG DUO pregnancy test that has 2 detection thresholds of 5 and 1000IU/L, 1 to 3 weeks after the abortion to assess the outcome. Within 1 month of the initial consultation, the women underwent a telephone consultation with the clinic that aimed to ascertain if there had been expulsion of products of conception and whether the hCG test was negative for either the 1000IU/L or 5IU/L concentrations.</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="l378"><li id="lt958" class="half_rhythm"><div>Missed ongoing pregnancy</div></li><li id="lt959" class="half_rhythm"><div>Patient satisfaction</div></li><li id="lt960" class="half_rhythm"><div>Unscheduled visits or telephone calls to the abortion service</div></li><li id="lt961" class="half_rhythm"><div>Surgical intervention</div></li></ul>
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</td></tr><tr><td headers="hd_h_ch9.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>
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<a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>
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</p>
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<p>Randomised controlled trial</p>
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<p>Moldova and Uzbekistan</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>n=2400</p>
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<p>Women requesting medical abortion of pregnancies ≤63 days’ gestation with no known contraindications to mifepristone and/or misoprostol.</p>
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</td><td headers="hd_h_ch9.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><b>Medical abortion:</b> 200mg oral mifepristone followed by 400mcg sublingual misoprostol 24 to 48 hours later.</p>
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<p><b>Clinic follow-up (Clinic):</b> Clinic-based follow-up 2 weeks after mifepristone administration assessing the abortion outcome by clinical examination, women’s report of symptoms, and ultrasound, if needed.</p>
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<p><b>Remote follow-up (Remote):</b> A semi-quantitative pregnancy test and a symptom checklist questionnaire to use at home before a scheduled phone-based follow-up appointment 2 weeks after mifepristone administration.</p>
|
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</td><td headers="hd_h_ch9.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="l379"><li id="lt962" class="half_rhythm"><div>Patient satisfaction</div></li><li id="lt963" class="half_rhythm"><div>Adherence to follow-up strategy</div></li><li id="lt964" class="half_rhythm"><div>Unscheduled visits to the abortion service</div></li><li id="lt965" class="half_rhythm"><div>Surgical intervention</div></li></ul>
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</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">hCG: human chorionic gonadotrophin; mcg: micrograms; US: ultrasound</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch9tab3"><div id="ch9.tab3" class="table"><h3><span class="label">Table 3</span><span class="title">Unit costs of pregnancy tests considered</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch9.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Resource</th><th id="hd_h_ch9.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Unit costs</th><th id="hd_h_ch9.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Source</th></tr></thead><tbody><tr><td headers="hd_h_ch9.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High Sensitivity pregnancy Test Kit<sup>1</sup></td><td headers="hd_h_ch9.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£0.74</td><td headers="hd_h_ch9.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NHS Supply Chain 2017</td></tr><tr><td headers="hd_h_ch9.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low Sensitivity Pregnancy Test Kit<sup>2</sup></td><td headers="hd_h_ch9.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£2.19</td><td headers="hd_h_ch9.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NHS Supply Chain 2017</td></tr><tr><td headers="hd_h_ch9.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nurses Time (5 minutes)<sup>2</sup></td><td headers="hd_h_ch9.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£3.08</td><td headers="hd_h_ch9.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PSSRU 2018</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch9.tab3_1"><p class="no_margin">Mean cost of all reported high sensitivity pregnancy tests</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch9.tab3_2"><p class="no_margin">Mean cost of all reported low sensitivity pregnancy tests</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch9.tab3_3"><p class="no_margin">Band 5 Nurse excluding qualification costs</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch9appatab1"><div id="ch9.appa.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.appa.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.appa.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Field (based on <a href="http://www.prisma-statement.org/Extensions/Protocols.aspx" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PRISMA-P</a></th><th id="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Content</th></tr></thead><tbody><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review question in SCOPE</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">What is the best method of excluding an ongoing pregnancy after early (up to 10 weeks) medical termination of pregnancy, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review question in guideline</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">What is the best method of excluding an ongoing pregnancy after early (up to 10<sup>+0</sup> weeks) medical termination of pregnancy, when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Type of review question</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objective of the review</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To determine the best method of excluding ongoing pregnancy when the expulsion has not been witnessed by healthcare professionals.</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – population</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<p>Women who have had a medical termination of pregnancy (up to 10<sup>+0</sup> weeks of gestation) with mifepristone and misoprostol and expelled the pregnancy at home</p>
|
|
<p>Exclusions:
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|
<dl id="l380" class="temp-labeled-list"><dl class="bkr_refwrap"><dt>-</dt><dd id="lt966"><p class="no_top_margin">No studies with indirect populations</p></dd></dl></dl></p>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – intervention(s)</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<ul id="l381"><li id="lt967" class="half_rhythm"><div>In-person assessment with an ultrasound scan (not keeping in women to check the expulsion)</div></li><li id="lt968" class="half_rhythm"><div>2. Remote assessment (e.g., consisting of low sensitivity urine pregnancy test, high sensitivity urine pregnancy test, multilevel urine pregnancy test, serum human chorionic gonadotropin (HCG), and/or self-assessment check lists)</div></li></ul>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – comparator(s)</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The following comparisons will be considered:
|
|
<ol id="l382"><li id="lt969" class="half_rhythm"><div>In-person assessment versus remote assessment</div></li><li id="lt970" class="half_rhythm"><div>Remote assessment protocol 1 versus remote assessment protocol 2</div></li></ol></td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes and prioritisation</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Critical outcomes:</b>
|
|
<ul id="l383"><li id="lt971" class="half_rhythm"><div>Missed ongoing pregnancy (failure to detect an ongoing pregnancy)</div></li><li id="lt972" class="half_rhythm"><div>Correct implementation of follow-up strategy (comprehension; i.e., the women understand how to undertake the remote self-assessment protocol)</div></li><li id="lt973" class="half_rhythm"><div>Patient satisfaction</div></li></ul>
|
|
<b>Important outcomes:</b>
|
|
<ul id="l384"><li id="lt974" class="half_rhythm"><div>Adherence to follow-up strategy</div></li><li id="lt975" class="half_rhythm"><div>Unscheduled visits or telephone calls to the termination service</div></li><li id="lt976" class="half_rhythm"><div>Surgical intervention</div></li></ul></td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – study design</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<dl id="l385" class="temp-labeled-list"><dl class="bkr_refwrap"><dt>-</dt><dd id="lt977"><p class="no_top_margin">Systematic reviews of RCTs</p></dd></dl><dl class="bkr_refwrap"><dt>-</dt><dd id="lt978"><p class="no_top_margin">RCTs</p></dd></dl></dl>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other inclusion exclusion criteria</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inclusion:
|
|
<dl id="l386" class="temp-labeled-list"><dl class="bkr_refwrap"><dt>-</dt><dd id="lt979"><p class="no_top_margin">English-language</p></dd></dl></dl></td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Proposed sensitivity/sub-group analysis, or meta-regression</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Stratified analyses based on the following sub-groups of women, where possible:</p>
|
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<p>Medical conditions:
|
|
<dl id="l387" class="temp-labeled-list"><dl class="bkr_refwrap"><dt>-</dt><dd id="lt980"><p class="no_top_margin">Complex pre-existing medical conditions</p></dd></dl><dl class="bkr_refwrap"><dt>-</dt><dd id="lt981"><p class="no_top_margin">No complex pre-existing medical conditions</p></dd></dl></dl>
|
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English speaking versus non-English speaking</p>
|
|
<p>Age <18 or ≥18 years</p>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Selection process – duplicate screening/selection/analysis</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Dual sifting will be undertaken for this question using NGA STAR software, with resolution of discrepancies in discussion with the senior reviewer if necessary.</p>
|
|
<p>Sifting, data extraction, appraisal of methodological quality and GRADE assessment will be performed by the systematic reviewer.</p>
|
|
<p>Quality control will be performed by the senior systematic reviewer.</p>
|
|
<p>Dual data extraction will not be performed for this question.</p>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data management (software)</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Pairwise meta-analyses of RCT data will be performed using Cochrane Review Manager (RevMan5).</p>
|
|
<p>‘GRADEpro’ will be used to assess the quality of evidence for each outcome.</p>
|
|
<p>NGA STAR software will be used for study sifting, data extraction, recording quality assessment using checklists and generating bibliographies/citations,</p>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Information sources – databases and dates</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Sources to be searched: Medline, Medline In-Process, CCTR, CDSR, DARE, HTA, Embase</p>
|
|
<p>Limits (e.g. date, study design):</p>
|
|
<p>Apply standard animal/non-English language exclusion</p>
|
|
<p>Dates: 2000 onwards</p>
|
|
<p>A date limit of 2000 will be applied because after 2000 clinical practice changed to include the possibility of remote assessment for successful termination of an early pregnancy when the expulsion has not been witnessed by healthcare professionals (for example, expulsion at home)?</p>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Identify if an update</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not an update</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Author contacts</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the guideline in development web site</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Highlight if amendment to previous protocol</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 4.5 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy – for one database</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see <a href="#ch9.appb">appendix B</a></td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data collection process – forms/duplicate</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A standardised evidence table format will be used, and published as <a href="#ch9.appd">appendix D</a> (clinical evidence tables) or <a href="#ch9.apph">H</a> (economic evidence tables)</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data items – define all variables to be collected</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see evidence tables in <a href="#ch9.appd">appendix D</a> (clinical evidence tables) or <a href="#ch9.apph">H</a> (economic evidence tables)</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for assessing bias at outcome/study level</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Standard study checklists will be used to critically appraise individual studies. For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></p>
|
|
<p>Appraisal of methodological quality:</p>
|
|
<p>The methodological quality of each study will be assessed using an appropriate checklist:
|
|
<ul id="l388"><li id="lt982" class="half_rhythm"><div>Cochrane risk of bias tool for RCTs</div></li></ul>
|
|
The risk of bias across all available evidence will be evaluated for each outcome using an adaptation of the ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) toolbox’ developed by the international GRADE working group <a href="http://www.gradeworkinggroup.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.gradeworkinggroup.org/</a></p>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Criteria for quantitative synthesis (where suitable)</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.4 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for analysis – combining studies and exploring (in)consistency</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Synthesis of data:</p>
|
|
<p>Pairwise meta-analysis will be conducted where appropriate for all outcomes.</p>
|
|
<p>When meta-analysing continuous data, change scores will be pooled in preference to final scores.</p>
|
|
<p>For details regarding inconsistency, please see the <a href="/books/NBK561071/bin/bm1.pdf">methods</a> chapter</p>
|
|
<p>Minimally important differences:</p>
|
|
<p>Default values will be used of: 0.8 and 1.25 for dichotomous outcomes (relative risks); 0.5 times SD (of control group) for continuous outcomes.</p>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-bias assessment – publication bias, selective reporting bias</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>For details please see section 6.2 of Developing NICE guidelines: the manual.</p>
|
|
<p>If sufficient relevant RCT evidence is available, publication bias will be explored using RevMan software to examine funnel plots.</p>
|
|
</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Assessment of confidence in cumulative evidence</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see sections 6.4 and 9.1 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rationale/context – Current management</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the introduction to the evidence review</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Describe contributions of authors and guarantor</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>A multidisciplinary committee developed the guideline. The committee was convened by The National Guideline Alliance and chaired by Profession Iain Cameron in line with section 3 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</p>
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<p>Staff from The National Guideline Alliance will undertake systematic literature searches, appraise the evidence, conduct meta-analysis and cost-effectiveness analysis where appropriate, and draft the guideline in collaboration with the committee. For details please see the <a href="/books/NBK561071/bin/bm1.pdf">methods</a> chapter</p>
|
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</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sources of funding/support</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The National Guideline Alliance is funded by NICE and hosted by the Royal College of Obstetricians and Gynaecologists</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Name of sponsor</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The National Guideline Alliance is funded by NICE and hosted by the Royal College of Obstetricians and Gynaecologists</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Roles of sponsor</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE funds The National Guideline Alliance to develop guidelines for those working in the NHS, public health, and social care in England</td></tr><tr><td headers="hd_h_ch9.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PROSPERO registration number</td><td headers="hd_h_ch9.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not registered</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">GRADE: Grading of Recommendations Assessment, Development and Evaluation; HCG: human chorionic gonadotropin; NHS: National Health Service; NICE: National Institute for Health and Care Excellence; NGA: National Guideline Alliance; RCT: randomised controlled trial; SD: standard deviation;</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch9appbtab1"><div id="ch9.appb.tab1" class="table"><h3><span class="title">Date of last search: 19<sup>th</sup> November 2018</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.appb.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.appb.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#</th><th id="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Searches</th></tr></thead><tbody><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp abortion/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp pregnancy termination/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Abortion, Induced/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Abortion Applicants/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Abortion, Spontaneous/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Abortion, Criminal/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Aborted fetus/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">fetus death/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">abortion.mp.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(abort$ or postabort$ or preabort$).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((f?etal$ or f?etus$ or gestat$ or midtrimester$ or pregnan$ or prenatal$ or pre natal$ or trimester$) and terminat$).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((f?etal$ or f?etus$) adj loss$).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((gestat$ or midtrimester$ or pregnan$ or prenatal$ or pre natal$ or trimester$) adj3 loss$).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((elective$ or threaten$ or voluntar$) adj3 interrupt$) and pregnan$).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Pregnancy Tests/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp pregnancy test/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((pregnan$ or LSPT or MSPT or HSPT or MLPT or HLPT or LSUP or MSUP or HSUP) adj test$).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-Assessment/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">self evaluation/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Self Report/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*self report/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Checklist/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">checklist/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((self-assess$ or selfassess$ or self assess$ or self-evaluat$ or selfevaluat$ or self evaluat$) adj3 (success or outcome$ or complet$ or home or remote)).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">checklist$.tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Chorionic Gonadotropin/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">chorionic gonadotropin/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((beta-hcg$ or hcg$) adj (test$ or level$ or measurement$)).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Telemedicine/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp telemedicine/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(telemed$ or teleconsult$).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self Administration/ use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">drug self administration/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp home/ or home care/) use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">home monitoring/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">follow up/ use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((follow-up or followup or follow up) adj (care or model$ or procedure$)).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((simple$ or standard$ or traditional$ or mToP) adj (follow-up or followup or follow up)).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((in-person$ or in-clinic$ or in-office$ or remote$ or telephone$ or ultrasound$ or ultrasonograph$ or sonogra$ or endosonogra$) adj3 (follow-up or followup or follow up or assess$)).tw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 and 41</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(controlled clinical trial or pragmatic clinical trial or randomized controlled trial).pt. or drug therapy.fs. or (groups or placebo or randomi#ed or randomly or trial).ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">crossover procedure/ or double blind procedure/ or randomized controlled trial/ or single blind procedure/ or (assign* or allocat* or crossover* or cross over* or ((doubl* or singl*) adj blind*) or factorial* or placebo* or random* or volunteer*).ti,ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">meta-analysis/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">meta-analysis as topic/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">systematic review/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">meta-analysis/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(meta analy* or metanaly* or metaanaly*).ti,ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((systematic or evidence) adj2 (review* or overview*)).ti,ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((systematic* or evidence*) adj2 (review* or overview*)).ti,ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(reference list* or bibliograph* or hand search* or manual search* or relevant journals).ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(search strategy or search criteria or systematic search or study selection or data extraction).ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(search* adj4 literature).ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(medline or pubmed or cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or science citation index or bids or cancerlit).ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cochrane.jw.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((pool* or combined) adj2 (data or trials or studies or results)).ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">news/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp historical article/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">comment/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58 or 59 or 60 or 61 or 62 or 63 or 64 or 65</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66 not 67</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animals, Laboratory/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experimentation/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Models, Animal/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68 or 69 or 70 or 71 or 72 or 73 or 74</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76 or 77 or 78 or 79 or 80</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81 not 82</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83 or 84 or 85 or 86 or 87 or 88 or 89 or 90</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75 use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91 use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92 or 93</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43 use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44 use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95 or 96</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or/45-46,49,51-56) use ppez</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or/47-50,52-57) use emczd</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">100</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98 or 99</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42 and 94</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">102</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42 not 101</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">103</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97 or 100</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">104</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">102 and 103</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">105</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 104 to english language</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">106</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 105 to yr="2000 -Current”</td></tr><tr><td headers="hd_h_ch9.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch9.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">remove duplicates from 106</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch9appbtab2"><div id="ch9.appb.tab2" class="table"><h3><span class="title">Date of last search: 19<sup>th</sup> November 2018</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.appb.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.appb.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#</th><th id="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Searches</th></tr></thead><tbody><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Abortion, Induced] explode all trees</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#2</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Abortion Applicants] explode all trees</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#3</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Abortion, Spontaneous] explode all trees</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#4</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Abortion, Criminal] explode all trees</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#5</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Aborted Fetus] explode all trees</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#6</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“abortion":ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#7</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(abort* or postabort* or preabort*):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#8</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((fetal* or fetus* or foetal* or foetus* or gestat* or midtrimester* or pregnan* or prenatal* or pre natal* or trimester*) and terminat*):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#9</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((fetal* or fetus* or foetal* or foetus*) next loss*):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#10</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((gestat* or midtrimester* or pregnan* or prenatal* or pre natal* or trimester*) near/3 loss*):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#11</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((elective* or threaten* or voluntar*) near/3 interrupt*) and pregnan*):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#12</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#13</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Pregnancy Tests] explode all trees</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((pregnan* or LSPT or MSPT or HSPT or MLPT or HLPT or LSUP or MSUP or HSUP) next test*):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#15</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Self-Assessment] this term only</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#16</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Self Report] this term only</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#17</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Checklist] this term only</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#18</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((self-assess* or selfassess* or self assess* or self-evaluat* or selfevaluat* or self evaluat*) near/3 (success or outcome* or complet* or home or remote)):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#19</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">checklist*:ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#20</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Chorionic Gonadotropin] explode all trees</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#21</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((beta-hcg* or hcg*) next (test* or level* or measurement*)):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#22</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Telemedicine] explode all trees</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#23</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(telemed* or teleconsult*):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#24</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Self Administration] this term only</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#25</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((follow-up or followup or follow up) next (care or model* or procedure*)):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#26</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((simple* or standard* or traditional* or mToP) next (follow-up or followup or follow up)):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((in-person* or in-clinic* or in-office* or remote* or telephone* or ultrasound* or ultrasonograph* or sonogra* or endosonogra*) near/3 (follow-up or followup or follow up or assess*)):ti,ab,kw (Word variations have been searched)</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#28</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27</td></tr><tr><td headers="hd_h_ch9.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#29</td><td headers="hd_h_ch9.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#12 and #28</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch9appcfig1"><div id="ch9.appc.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20Study%20selection%20flow%20chart.&p=BOOKS&id=561071_ch9appcf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK561071/bin/ch9appcf1.jpg" alt="Figure 1. Study selection flow chart." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">Study selection flow chart</span></h3></div></article><article data-type="fig" id="figobch9appefig1"><div id="ch9.appe.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%202.%20Missed%20ongoing%20pregnancy.&p=BOOKS&id=561071_ch9appef1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK561071/bin/ch9appef1.jpg" alt="Figure 2. Missed ongoing pregnancy." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 2</span><span class="title">Missed ongoing pregnancy</span></h3></div></article><article data-type="fig" id="figobch9appefig2"><div id="ch9.appe.fig2" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%203.%20Patient%20satisfaction%20(Prefer%20remote%20follow%20up%20for%20managing%20abortion%20follow%20up%20in%20the%20future)%20Not%20meta-analysed%20due%20to%20high%20heterogeneity%20(I2%20%3D%2099%25).&p=BOOKS&id=561071_ch9appef2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK561071/bin/ch9appef2.jpg" alt="Figure 3. Patient satisfaction (Prefer remote follow up for managing abortion follow up in the future) Not meta-analysed due to high heterogeneity (I2 = 99%)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 3</span><span class="title">Patient satisfaction (Prefer remote follow up for managing abortion follow up in the future) <i>Not meta-analysed due to high heterogeneity (I<sup>2</sup> = 99%)</i></span></h3><div class="caption"><p>(1) High proportion of missing data, but sensitivity analyses showed that if all the missing data were preference for assigned method [Clinic: 333/466; Remote: 400/458] or preference for non-assigned method [Clinic: 190/466; Remote: 272/458], the results still favoured statistically significantly remote assessment.</p></div></div></article><article data-type="fig" id="figobch9appefig3"><div id="ch9.appe.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%204.%20Adherence%20to%20follow-up%20strategy%3B%20Not%20meta-analysed%20due%20to%20high%20heterogeneity%20(I2%20%3D%2093%25).&p=BOOKS&id=561071_ch9appef3.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK561071/bin/ch9appef3.jpg" alt="Figure 4. Adherence to follow-up strategy; Not meta-analysed due to high heterogeneity (I2 = 93%)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 4</span><span class="title">Adherence to follow-up strategy; Not meta-analysed due to high heterogeneity (I<sup>2</sup> = 93%)</span></h3></div></article><article data-type="fig" id="figobch9appefig4"><div id="ch9.appe.fig4" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%205.%20Unscheduled%20visits%20to%20the%20abortion%20service.&p=BOOKS&id=561071_ch9appef4.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK561071/bin/ch9appef4.jpg" alt="Figure 5. Unscheduled visits to the abortion service." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 5</span><span class="title">Unscheduled visits to the abortion service</span></h3></div></article><article data-type="fig" id="figobch9appefig5"><div id="ch9.appe.fig5" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%206.%20Surgical%20intervention.&p=BOOKS&id=561071_ch9appef5.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK561071/bin/ch9appef5.jpg" alt="Figure 6. Surgical intervention." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 6</span><span class="title">Surgical intervention</span></h3><div class="caption"><p>(2) Surgical intervention for ongoing pregnancy, evacuation of retained products of conception, incomplete or missed abortion, heavy bleeding, or requested by the woman</p></div></div></article><article data-type="table-wrap" id="figobch9appftab1"><div id="ch9.appf.tab1" class="table"><h3><span class="label">Table 4</span><span class="title">Clinical evidence profile: Comparison 1. Remote follow-up versus clinic follow-up</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.appf.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.appf.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch9.appf.tab1_1_1_1_1" colspan="7" rowspan="1" style="text-align:left;vertical-align:bottom;">Quality assessment</th><th id="hd_h_ch9.appf.tab1_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">No of patients</th><th id="hd_h_ch9.appf.tab1_1_1_1_3" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Effect</th><th id="hd_h_ch9.appf.tab1_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch9.appf.tab1_1_1_1_4" style="text-align:left;vertical-align:bottom;">Quality</th><th id="hd_h_ch9.appf.tab1_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch9.appf.tab1_1_1_1_5" style="text-align:left;vertical-align:bottom;">Importance</th></tr><tr><th headers="hd_h_ch9.appf.tab1_1_1_1_1" id="hd_h_ch9.appf.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No of studies</th><th headers="hd_h_ch9.appf.tab1_1_1_1_1" id="hd_h_ch9.appf.tab1_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Design</th><th headers="hd_h_ch9.appf.tab1_1_1_1_1" id="hd_h_ch9.appf.tab1_1_1_2_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th headers="hd_h_ch9.appf.tab1_1_1_1_1" id="hd_h_ch9.appf.tab1_1_1_2_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th headers="hd_h_ch9.appf.tab1_1_1_1_1" id="hd_h_ch9.appf.tab1_1_1_2_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th headers="hd_h_ch9.appf.tab1_1_1_1_1" id="hd_h_ch9.appf.tab1_1_1_2_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Imprecision</th><th headers="hd_h_ch9.appf.tab1_1_1_1_1" id="hd_h_ch9.appf.tab1_1_1_2_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Other considerations</th><th headers="hd_h_ch9.appf.tab1_1_1_1_2" id="hd_h_ch9.appf.tab1_1_1_2_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Remote follow up</th><th headers="hd_h_ch9.appf.tab1_1_1_1_2" id="hd_h_ch9.appf.tab1_1_1_2_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Clinic follow-up</th><th headers="hd_h_ch9.appf.tab1_1_1_1_3" id="hd_h_ch9.appf.tab1_1_1_2_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relative (95% CI)</th><th headers="hd_h_ch9.appf.tab1_1_1_1_3" id="hd_h_ch9.appf.tab1_1_1_2_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_h_ch9.appf.tab1_1_1_2_3 hd_h_ch9.appf.tab1_1_1_2_4 hd_h_ch9.appf.tab1_1_1_2_5 hd_h_ch9.appf.tab1_1_1_2_6 hd_h_ch9.appf.tab1_1_1_2_7 hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_h_ch9.appf.tab1_1_1_2_9 hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_h_ch9.appf.tab1_1_1_2_11 hd_h_ch9.appf.tab1_1_1_1_4 hd_h_ch9.appf.tab1_1_1_1_5" id="hd_b_ch9.appf.tab1_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Missed ongoing pregnancy (follow-up 2-13 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>; <a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>; <a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_3 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_4 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_5 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious indirectness<sup>2</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_6 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>3</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_7 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>4/1481</p>
|
|
<p>(0.27%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/1454</p>
|
|
<p>(0%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 4.91 (0.58 to 41.54)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not estimable</td><td headers="hd_h_ch9.appf.tab1_1_1_1_4 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch9.appf.tab1_1_1_1_5 hd_b_ch9.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_h_ch9.appf.tab1_1_1_2_3 hd_h_ch9.appf.tab1_1_1_2_4 hd_h_ch9.appf.tab1_1_1_2_5 hd_h_ch9.appf.tab1_1_1_2_6 hd_h_ch9.appf.tab1_1_1_2_7 hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_h_ch9.appf.tab1_1_1_2_9 hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_h_ch9.appf.tab1_1_1_2_11 hd_h_ch9.appf.tab1_1_1_1_4 hd_h_ch9.appf.tab1_1_1_1_5" id="hd_b_ch9.appf.tab1_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Patient satisfaction (Prefer remote follow-up for managing abortion follow-up in future) (follow-up 2-13 weeks) Not meta-analysed due to high heterogeneity</th></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">4 (<a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>; <a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>; <a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>; <a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_3 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_4 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>4</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_5 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>5</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_6 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">No serious imprecision<sup>6</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_7 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>: 277/326</p>
|
|
<p>(84.97%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>: 294/355</p>
|
|
<p>(82.82%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.03 (0.96 to 1.1)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25 more per 1000 (from 33 fewer to 83 more)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_4 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch9.appf.tab1_1_1_1_5 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>: 606/686</p>
|
|
<p>(88.34%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>: 256/642</p>
|
|
<p>(39.88%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 2.22 (2.01 to 2.45)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">486 more per 1000 (from 403 more to 578 more)</td></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>: 272/330</p>
|
|
<p>(82.42%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>: 190/323</p>
|
|
<p>(58.82%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.4 (1.26 to 1.55)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">235 more per 1000 (from 153 more to 324 more)</td></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>: 913/1199</p>
|
|
<p>(76.15%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>: 577/1199</p>
|
|
<p>(48.12%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.58 (1.48 to 1.69)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">279 more per 1000 (from 231 more to 332 more)</td></tr><tr><th headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_h_ch9.appf.tab1_1_1_2_3 hd_h_ch9.appf.tab1_1_1_2_4 hd_h_ch9.appf.tab1_1_1_2_5 hd_h_ch9.appf.tab1_1_1_2_6 hd_h_ch9.appf.tab1_1_1_2_7 hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_h_ch9.appf.tab1_1_1_2_9 hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_h_ch9.appf.tab1_1_1_2_11 hd_h_ch9.appf.tab1_1_1_1_4 hd_h_ch9.appf.tab1_1_1_1_5" id="hd_b_ch9.appf.tab1_1_1_8_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Adherence to follow-up strategy (follow-up 2-3 weeks) Not meta-analysed due to high heterogeneity</th></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>; <a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>; <a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_3 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">No serious risk of bias</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_4 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>7</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_5 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>8</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_6 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">No serious imprecision</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_7 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>: 322/469</p>
|
|
<p>(68.66%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>: 337/464</p>
|
|
<p>(72.63%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.95 (0.87 to 1.03)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36 fewer per 1000 (from 94 fewer to 22 more)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_4 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch9.appf.tab1_1_1_1_5 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>: 693/713</p>
|
|
<p>(97.19%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>: 652/720</p>
|
|
<p>(90.56%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.07 (1.05 to 1.1)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63 more per 1000 (from 45 more to 91 more)</td></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>: 1163/1200</p>
|
|
<p>(96.92%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>: 1170/1200</p>
|
|
<p>(97.5%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.99 (0.98 to 1.01)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10 fewer per 1000 (from 19 fewer to 10 more)</td></tr><tr><th headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_h_ch9.appf.tab1_1_1_2_3 hd_h_ch9.appf.tab1_1_1_2_4 hd_h_ch9.appf.tab1_1_1_2_5 hd_h_ch9.appf.tab1_1_1_2_6 hd_h_ch9.appf.tab1_1_1_2_7 hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_h_ch9.appf.tab1_1_1_2_9 hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_h_ch9.appf.tab1_1_1_2_11 hd_h_ch9.appf.tab1_1_1_1_4 hd_h_ch9.appf.tab1_1_1_1_5" id="hd_b_ch9.appf.tab1_1_1_12_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Unscheduled visits to the termination service (follow-up 2-13 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4 (<a href="/books/n/niceng140er7/?report=reader" class="toc-item">Bracken 2014</a>; <a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>; <a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>; <a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_3 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>9</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_4 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_5 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious indirectness</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_6 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>10</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_7 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>106/2726</p>
|
|
<p>(3.9%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>88/2728</p>
|
|
<p>(3.2%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.2 (0.91 to 1.59)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6 more per 1000 (from 3 fewer to 19 more)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_4 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">LOW</td><td headers="hd_h_ch9.appf.tab1_1_1_1_5 hd_b_ch9.appf.tab1_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_h_ch9.appf.tab1_1_1_2_3 hd_h_ch9.appf.tab1_1_1_2_4 hd_h_ch9.appf.tab1_1_1_2_5 hd_h_ch9.appf.tab1_1_1_2_6 hd_h_ch9.appf.tab1_1_1_2_7 hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_h_ch9.appf.tab1_1_1_2_9 hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_h_ch9.appf.tab1_1_1_2_11 hd_h_ch9.appf.tab1_1_1_1_4 hd_h_ch9.appf.tab1_1_1_1_5" id="hd_b_ch9.appf.tab1_1_1_14_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Unscheduled telephone calls to the termination service (follow-up 13 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_3 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>11</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_4 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_5 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious indirectness</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_6 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>3</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_7 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>68/346</p>
|
|
<p>(19.7%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>65/348</p>
|
|
<p>(18.7%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.05 (0.78 to 1.43)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 more per 1000 (from 41 fewer to 80 more)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_4 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch9.appf.tab1_1_1_1_5 hd_b_ch9.appf.tab1_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_h_ch9.appf.tab1_1_1_2_3 hd_h_ch9.appf.tab1_1_1_2_4 hd_h_ch9.appf.tab1_1_1_2_5 hd_h_ch9.appf.tab1_1_1_2_6 hd_h_ch9.appf.tab1_1_1_2_7 hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_h_ch9.appf.tab1_1_1_2_9 hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_h_ch9.appf.tab1_1_1_2_11 hd_h_ch9.appf.tab1_1_1_1_4 hd_h_ch9.appf.tab1_1_1_1_5" id="hd_b_ch9.appf.tab1_1_1_16_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Surgical intervention (follow-up 2-13 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_1 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4 (<a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>; <a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>; <a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a>; <a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_2 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_3 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>9</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_4 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_5 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>5</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_6 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>10</sup></td><td headers="hd_h_ch9.appf.tab1_1_1_1_1 hd_h_ch9.appf.tab1_1_1_2_7 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_8 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>91/2837</p>
|
|
<p>(3.2%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_2 hd_h_ch9.appf.tab1_1_1_2_9 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>99/2866</p>
|
|
<p>(3.5%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_10 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.93 (0.7 to 1.23)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_3 hd_h_ch9.appf.tab1_1_1_2_11 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 fewer per 1000 (from 10 fewer to 8 more)</td><td headers="hd_h_ch9.appf.tab1_1_1_1_4 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch9.appf.tab1_1_1_1_5 hd_b_ch9.appf.tab1_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">CI: confidence interval; MID: minimally important difference; RR: relative risk</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch9.appf.tab1_1"><p class="no_margin">All the studies were unblinded, and in one of them there was high risk of attrition bias.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch9.appf.tab1_2"><p class="no_margin">In one of the studies, it was unclear how many women received ultrasound as part of the follow-up in the clinic follow-up group.</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch9.appf.tab1_3"><p class="no_margin">The 95% CI crosses two MID thresholds.</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch9.appf.tab1_4"><p class="no_margin">Very high heterogeneity (I<sup>2</sup> = 99%)</p></div></dd></dl><dl class="bkr_refwrap"><dt>5</dt><dd><div id="ch9.appf.tab1_5"><p class="no_margin">In two of the studies, it was unclear how many women received ultrasound as part of the follow-up in the clinic follow-up group. Moreover, the outcome itself is indirect and is only reported because none of the studies reported the target outcome of patient satisfaction.</p></div></dd></dl><dl class="bkr_refwrap"><dt>6</dt><dd><div id="ch9.appf.tab1_6"><p class="no_margin">The results are not downgraded for imprecision as they have already been downgraded two levels for inconsistency and they are in agreement that women either prefer remote follow-up (<a class="bibr" href="#ch9.s1.1.ref4" rid="ch9.s1.1.ref4">Ngoc 2014</a>, <a class="bibr" href="#ch9.s1.1.ref5" rid="ch9.s1.1.ref5">Oppegaard 2015</a> and <a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>) or that there is no difference between their preference for remote or clinic follow-up (<a class="bibr" href="#ch9.s1.1.ref2" rid="ch9.s1.1.ref2">Bracken 2014</a>)</p></div></dd></dl><dl class="bkr_refwrap"><dt>7</dt><dd><div id="ch9.appf.tab1_7"><p class="no_margin">Very high heterogeneity (I<sup>2</sup> = 93%)</p></div></dd></dl><dl class="bkr_refwrap"><dt>8</dt><dd><div id="ch9.appf.tab1_8"><p class="no_margin">In the largest study (<a class="bibr" href="#ch9.s1.1.ref6" rid="ch9.s1.1.ref6">Platais 2015</a>), it was unclear how many women received ultrasound as part of the follow-up in the clinic follow-up group.</p></div></dd></dl><dl class="bkr_refwrap"><dt>9</dt><dd><div id="ch9.appf.tab1_9"><p class="no_margin">All the studies were unblinded.</p></div></dd></dl><dl class="bkr_refwrap"><dt>10</dt><dd><div id="ch9.appf.tab1_10"><p class="no_margin">The 95% CI crosses one MID threshold</p></div></dd></dl><dl class="bkr_refwrap"><dt>11</dt><dd><div id="ch9.appf.tab1_11"><p class="no_margin">The study was unblinded.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch9appftab2"><div id="ch9.appf.tab2" class="table"><h3><span class="label">Table 5</span><span class="title">Clinical evidence profile: Comparison 2. Remote follow-up ‘Multi-level pregnancy test’ versus remote follow-up ‘High sensitivity pregnancy test’</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.appf.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.appf.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch9.appf.tab2_1_1_1_1" colspan="7" rowspan="1" style="text-align:left;vertical-align:bottom;">Quality assessment</th><th id="hd_h_ch9.appf.tab2_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">No of patients</th><th id="hd_h_ch9.appf.tab2_1_1_1_3" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Effect</th><th id="hd_h_ch9.appf.tab2_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch9.appf.tab2_1_1_1_4" style="text-align:left;vertical-align:bottom;">Quality</th><th id="hd_h_ch9.appf.tab2_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch9.appf.tab2_1_1_1_5" style="text-align:left;vertical-align:bottom;">Importance</th></tr><tr><th headers="hd_h_ch9.appf.tab2_1_1_1_1" id="hd_h_ch9.appf.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No of studies</th><th headers="hd_h_ch9.appf.tab2_1_1_1_1" id="hd_h_ch9.appf.tab2_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Design</th><th headers="hd_h_ch9.appf.tab2_1_1_1_1" id="hd_h_ch9.appf.tab2_1_1_2_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th headers="hd_h_ch9.appf.tab2_1_1_1_1" id="hd_h_ch9.appf.tab2_1_1_2_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th headers="hd_h_ch9.appf.tab2_1_1_1_1" id="hd_h_ch9.appf.tab2_1_1_2_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th headers="hd_h_ch9.appf.tab2_1_1_1_1" id="hd_h_ch9.appf.tab2_1_1_2_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Imprecision</th><th headers="hd_h_ch9.appf.tab2_1_1_1_1" id="hd_h_ch9.appf.tab2_1_1_2_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Other considerations</th><th headers="hd_h_ch9.appf.tab2_1_1_1_2" id="hd_h_ch9.appf.tab2_1_1_2_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Multi-level pregnancy test</th><th headers="hd_h_ch9.appf.tab2_1_1_1_2" id="hd_h_ch9.appf.tab2_1_1_2_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">High sensitivity pregnancy test</th><th headers="hd_h_ch9.appf.tab2_1_1_1_3" id="hd_h_ch9.appf.tab2_1_1_2_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relative (95% CI)</th><th headers="hd_h_ch9.appf.tab2_1_1_1_3" id="hd_h_ch9.appf.tab2_1_1_2_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_1 hd_h_ch9.appf.tab2_1_1_2_2 hd_h_ch9.appf.tab2_1_1_2_3 hd_h_ch9.appf.tab2_1_1_2_4 hd_h_ch9.appf.tab2_1_1_2_5 hd_h_ch9.appf.tab2_1_1_2_6 hd_h_ch9.appf.tab2_1_1_2_7 hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_8 hd_h_ch9.appf.tab2_1_1_2_9 hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_10 hd_h_ch9.appf.tab2_1_1_2_11 hd_h_ch9.appf.tab2_1_1_1_4 hd_h_ch9.appf.tab2_1_1_1_5" id="hd_b_ch9.appf.tab2_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Missed ongoing pregnancy (follow-up 2 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_1 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch9.s1.1.ref1" rid="ch9.s1.1.ref1">Blum 2016</a>)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_2 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_3 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious risk of bias</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_4 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_5 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious indirectness</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_6 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_7 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_8 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/293</p>
|
|
<p>(0%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_9 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/291</p>
|
|
<p>(0%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_10 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not estimable</td><td headers="hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_11 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not estimable</td><td headers="hd_h_ch9.appf.tab2_1_1_1_4 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">LOW</td><td headers="hd_h_ch9.appf.tab2_1_1_1_5 hd_b_ch9.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_1 hd_h_ch9.appf.tab2_1_1_2_2 hd_h_ch9.appf.tab2_1_1_2_3 hd_h_ch9.appf.tab2_1_1_2_4 hd_h_ch9.appf.tab2_1_1_2_5 hd_h_ch9.appf.tab2_1_1_2_6 hd_h_ch9.appf.tab2_1_1_2_7 hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_8 hd_h_ch9.appf.tab2_1_1_2_9 hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_10 hd_h_ch9.appf.tab2_1_1_2_11 hd_h_ch9.appf.tab2_1_1_1_4 hd_h_ch9.appf.tab2_1_1_1_5" id="hd_b_ch9.appf.tab2_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Patient satisfaction (Prefer remote follow-up for managing abortion follow-up in future) (follow-up 2 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_1 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch9.s1.1.ref1" rid="ch9.s1.1.ref1">Blum 2016</a>)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_2 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_3 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_4 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_5 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious indirectness<sup>3</sup></td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_6 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious imprecision</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_7 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_8 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>257/293</p>
|
|
<p>(87.7%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_9 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>263/291</p>
|
|
<p>(90.4%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_10 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.97 (0.92 to 1.03)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_11 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27 fewer per 1000 (from 72 fewer to 27 more)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_4 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MODERATE</td><td headers="hd_h_ch9.appf.tab2_1_1_1_5 hd_b_ch9.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_1 hd_h_ch9.appf.tab2_1_1_2_2 hd_h_ch9.appf.tab2_1_1_2_3 hd_h_ch9.appf.tab2_1_1_2_4 hd_h_ch9.appf.tab2_1_1_2_5 hd_h_ch9.appf.tab2_1_1_2_6 hd_h_ch9.appf.tab2_1_1_2_7 hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_8 hd_h_ch9.appf.tab2_1_1_2_9 hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_10 hd_h_ch9.appf.tab2_1_1_2_11 hd_h_ch9.appf.tab2_1_1_1_4 hd_h_ch9.appf.tab2_1_1_1_5" id="hd_b_ch9.appf.tab2_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Unscheduled visits to the termination service (follow-up 2 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_1 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch9.s1.1.ref1" rid="ch9.s1.1.ref1">Blum 2016</a>)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_2 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_3 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_4 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_5 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious indirectness</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_6 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious imprecision</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_7 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_8 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>5/293</p>
|
|
<p>(1.7%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_9 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>56/291</p>
|
|
<p>(19.2%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_10 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.09 (0.04 to 0.22)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_11 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">175 fewer per 1000 (from 150 fewer to 185 fewer)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_4 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MODERATE</td><td headers="hd_h_ch9.appf.tab2_1_1_1_5 hd_b_ch9.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_1 hd_h_ch9.appf.tab2_1_1_2_2 hd_h_ch9.appf.tab2_1_1_2_3 hd_h_ch9.appf.tab2_1_1_2_4 hd_h_ch9.appf.tab2_1_1_2_5 hd_h_ch9.appf.tab2_1_1_2_6 hd_h_ch9.appf.tab2_1_1_2_7 hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_8 hd_h_ch9.appf.tab2_1_1_2_9 hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_10 hd_h_ch9.appf.tab2_1_1_2_11 hd_h_ch9.appf.tab2_1_1_1_4 hd_h_ch9.appf.tab2_1_1_1_5" id="hd_b_ch9.appf.tab2_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Surgical intervention (follow-up 2 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_1 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch9.s1.1.ref1" rid="ch9.s1.1.ref1">Blum 2016</a>)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_2 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_3 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_4 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_5 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious indirectness</td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_6 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>4</sup></td><td headers="hd_h_ch9.appf.tab2_1_1_1_1 hd_h_ch9.appf.tab2_1_1_2_7 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_8 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/293</p>
|
|
<p>(0%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab2_1_1_1_2 hd_h_ch9.appf.tab2_1_1_2_9 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>1/291</p>
|
|
<p>(0.34%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_10 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.33 (0.01 to 8.09)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_3 hd_h_ch9.appf.tab2_1_1_2_11 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 fewer per 1000 (from 3 fewer to 24 more)</td><td headers="hd_h_ch9.appf.tab2_1_1_1_4 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch9.appf.tab2_1_1_1_5 hd_b_ch9.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">CI: confidence interval; MID: minimally important difference; RR: relative risk</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch9.appf.tab2_1"><p class="no_margin">The study is not powered to detect this outcome.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch9.appf.tab2_2"><p class="no_margin">The study was unblinded.</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch9.appf.tab2_3"><p class="no_margin">The outcome itself is indirect and is only reported because the study reported the target outcome of patient satisfaction.</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch9.appf.tab2_4"><p class="no_margin">The 95% CI crosses two MID thresholds.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch9appftab3"><div id="ch9.appf.tab3" class="table"><h3><span class="label">Table 6</span><span class="title">Clinical evidence profile: Comparison 3. Remote follow-up ‘Demonstration’ versus remote follow-up ‘Instruction’</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.appf.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.appf.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch9.appf.tab3_1_1_1_1" colspan="7" rowspan="1" style="text-align:left;vertical-align:bottom;">Quality assessment</th><th id="hd_h_ch9.appf.tab3_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">No of patients</th><th id="hd_h_ch9.appf.tab3_1_1_1_3" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Effect</th><th id="hd_h_ch9.appf.tab3_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch9.appf.tab3_1_1_1_4" style="text-align:left;vertical-align:bottom;">Quality</th><th id="hd_h_ch9.appf.tab3_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch9.appf.tab3_1_1_1_5" style="text-align:left;vertical-align:bottom;">Importance</th></tr><tr><th headers="hd_h_ch9.appf.tab3_1_1_1_1" id="hd_h_ch9.appf.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No of studies</th><th headers="hd_h_ch9.appf.tab3_1_1_1_1" id="hd_h_ch9.appf.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Design</th><th headers="hd_h_ch9.appf.tab3_1_1_1_1" id="hd_h_ch9.appf.tab3_1_1_2_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th headers="hd_h_ch9.appf.tab3_1_1_1_1" id="hd_h_ch9.appf.tab3_1_1_2_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th headers="hd_h_ch9.appf.tab3_1_1_1_1" id="hd_h_ch9.appf.tab3_1_1_2_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th headers="hd_h_ch9.appf.tab3_1_1_1_1" id="hd_h_ch9.appf.tab3_1_1_2_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Imprecision</th><th headers="hd_h_ch9.appf.tab3_1_1_1_1" id="hd_h_ch9.appf.tab3_1_1_2_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Other considerations</th><th headers="hd_h_ch9.appf.tab3_1_1_1_2" id="hd_h_ch9.appf.tab3_1_1_2_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Demonstration</th><th headers="hd_h_ch9.appf.tab3_1_1_1_2" id="hd_h_ch9.appf.tab3_1_1_2_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Instruction</th><th headers="hd_h_ch9.appf.tab3_1_1_1_3" id="hd_h_ch9.appf.tab3_1_1_2_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relative (95% CI)</th><th headers="hd_h_ch9.appf.tab3_1_1_1_3" id="hd_h_ch9.appf.tab3_1_1_2_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_1 hd_h_ch9.appf.tab3_1_1_2_2 hd_h_ch9.appf.tab3_1_1_2_3 hd_h_ch9.appf.tab3_1_1_2_4 hd_h_ch9.appf.tab3_1_1_2_5 hd_h_ch9.appf.tab3_1_1_2_6 hd_h_ch9.appf.tab3_1_1_2_7 hd_h_ch9.appf.tab3_1_1_1_2 hd_h_ch9.appf.tab3_1_1_2_8 hd_h_ch9.appf.tab3_1_1_2_9 hd_h_ch9.appf.tab3_1_1_1_3 hd_h_ch9.appf.tab3_1_1_2_10 hd_h_ch9.appf.tab3_1_1_2_11 hd_h_ch9.appf.tab3_1_1_1_4 hd_h_ch9.appf.tab3_1_1_1_5" id="hd_b_ch9.appf.tab3_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Missed ongoing pregnancy (follow-up 2-4 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_1 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch9.s1.1.ref3" rid="ch9.s1.1.ref3">Constant 2017</a>)</td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_2 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_3 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_4 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_5 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious indirectness</td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_6 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_7 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab3_1_1_1_2 hd_h_ch9.appf.tab3_1_1_2_8 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>1/218</p>
|
|
<p>(0.46%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab3_1_1_1_2 hd_h_ch9.appf.tab3_1_1_2_9 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/208</p>
|
|
<p>(0%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab3_1_1_1_3 hd_h_ch9.appf.tab3_1_1_2_10 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 2.86 (0.12 to 69.89)</td><td headers="hd_h_ch9.appf.tab3_1_1_1_3 hd_h_ch9.appf.tab3_1_1_2_11 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not estimable</td><td headers="hd_h_ch9.appf.tab3_1_1_1_4 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch9.appf.tab3_1_1_1_5 hd_b_ch9.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_1 hd_h_ch9.appf.tab3_1_1_2_2 hd_h_ch9.appf.tab3_1_1_2_3 hd_h_ch9.appf.tab3_1_1_2_4 hd_h_ch9.appf.tab3_1_1_2_5 hd_h_ch9.appf.tab3_1_1_2_6 hd_h_ch9.appf.tab3_1_1_2_7 hd_h_ch9.appf.tab3_1_1_1_2 hd_h_ch9.appf.tab3_1_1_2_8 hd_h_ch9.appf.tab3_1_1_2_9 hd_h_ch9.appf.tab3_1_1_1_3 hd_h_ch9.appf.tab3_1_1_2_10 hd_h_ch9.appf.tab3_1_1_2_11 hd_h_ch9.appf.tab3_1_1_1_4 hd_h_ch9.appf.tab3_1_1_1_5" id="hd_b_ch9.appf.tab3_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Patient satisfaction (Prefer remote follow-up for managing abortion follow-up in future) (follow-up 2-4 weeks)</th></tr><tr><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_1 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch9.s1.1.ref3" rid="ch9.s1.1.ref3">Constant 2017</a>)</td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_2 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised trials</td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_3 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>3</sup></td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_4 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious inconsistency</td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_5 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious indirectness<sup>4</sup></td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_6 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No serious imprecision</td><td headers="hd_h_ch9.appf.tab3_1_1_1_1 hd_h_ch9.appf.tab3_1_1_2_7 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch9.appf.tab3_1_1_1_2 hd_h_ch9.appf.tab3_1_1_2_8 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>228/231</p>
|
|
<p>(98.7%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab3_1_1_1_2 hd_h_ch9.appf.tab3_1_1_2_9 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>223/227</p>
|
|
<p>(98.2%)</p>
|
|
</td><td headers="hd_h_ch9.appf.tab3_1_1_1_3 hd_h_ch9.appf.tab3_1_1_2_10 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1 (0.98 to 1.03)</td><td headers="hd_h_ch9.appf.tab3_1_1_1_3 hd_h_ch9.appf.tab3_1_1_2_11 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 fewer per 1000 (from 20 fewer to 29 more)</td><td headers="hd_h_ch9.appf.tab3_1_1_1_4 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">LOW</td><td headers="hd_h_ch9.appf.tab3_1_1_1_5 hd_b_ch9.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">CI: confidence interval; MID: minimally important difference; RR: relative risk</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch9.appf.tab3_1"><p class="no_margin">High risk of attrition bias.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch9.appf.tab3_2"><p class="no_margin">The 95% CI crosses two MID thresholds.</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch9.appf.tab3_3"><p class="no_margin">High risk of attrition bias and only the clinic staff, not the women or the field workers, were blinded.</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch9.appf.tab3_4"><p class="no_margin">The outcome itself is indirect and is only reported because the study reported the target outcome of patient satisfaction.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch9appktab1"><div id="ch9.appk.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK561071/table/ch9.appk.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch9.appk.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study</th><th id="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reason for Exclusion</th></tr></thead><tbody><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Clark,W., Bracken,H., Tanenhaus,J., Schweikert,S., Lichtenberg,E.S., Winikoff,B., Alternatives to a routine follow-up visit for early medical abortion, Obstetrics and Gynecology, 115, 264-272, 2010</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-randomised trial</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Constant, D., Daskilewicz, K., Harries, J., Myer, L., Gemzell-Danielsson, K., Instruction-only versus demonstration of a low sensitivity pregnancy test for self-assessment of medical abortion in South Africa; a multicentre non-inferiority randomised controlled trial, European Journal of Contraception and Reproductive Health Care, 21, 52-53, 2016</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Conference abstract only - full text available</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Constant, D., Daskilewicz, K., Harries, J., Myer, L., Gemzell-Danielsson, K., Self-assessment of medical abortion using a low-sensitivity pregnancy test, checklist and text messages in the South African public sector: A randomized controlled trial, Contraception, 92 (4), 373, 2015</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Conference abstract only - full text available</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Constant, D., de Tolly, K., Harries, J., Myer, L., Assessment of completion of early medical abortion using a text questionnaire on mobile phones compared to a self-administered paper questionnaire among women attending four clinics, Cape Town, South Africa, Reproductive Health Matters, Part S1. 22, 83-93, 2015</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">All women received in-person assessment; randomisation was to standard care versus standard care and text questionnaire</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dabash, R., Shochet, T., Hajri, S., Chelli, H., Hassairi, A. E., Haleb, D., Labassi, H., Sfar, E., Temimi, F., Koenig, L., Winikoff, B., Self-administered multi-level pregnancy tests in simplified follow-up of medical abortion in Tunisia, BMC Women’s Health, 16 (1) (no pagination), 2016</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-randomised trial</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">de Tolly, K. M., Constant, D., Integrating mobile phones into medical abortion provision: intervention development, use, and lessons learned from a randomized controlled trial, JMIR MHealth and UHealthJMIR Mhealth Uhealth, 2, e5, 2014</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Results of the randomised component of the trial not reported in this paper (reported in <a class="bibr" href="#ch9.s1.1.ref3" rid="ch9.s1.1.ref3">Constant 2017</a>)</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Debby,A., Malinger,G., Harow,E., Golan,A., Glezerman,M., Transvaginal ultrasound after first-trimester uterine evacuation reduces the incidence of retained products of conception, Ultrasound in Obstetrics and Gynecology, 27, 61-64, 2006</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population inconsistent with protocol: surgical abortion</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Godfrey, E. M., Anderson, A., Fielding, S. L., Meyn, L., Creinin, M. D., Clinical utility of urine pregnancy assays to determine medical abortion outcome is limited, Contraception, 75, 378-382, 2007</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Women received all methods of assessment for ongoing pregnancy; this component of the trial was not randomised</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Grossman, D., Grindlay, K., Alternatives to ultrasound for follow-up after medication abortion: A systematic review, Contraception, 83, 504-510, 2011</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-randomised trials</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Iyengar, K., Paul, M., Iyengar, S. D., Klingberg-Allvin, M., Essen, B., Bring, J., Soni, S., Gemzell-Danielsson, K., Self-assessment of the outcome of early medical abortion versus clinic follow-up in India: A randomised, controlled, non-inferiority trial, The Lancet Global Health, 3, 2015</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">In-person assessment did not use ultrasound</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nct,, Comparison of the Effectiveness of Treatment With Mifepristone and Misoprostol at the Same Time Compared to the Administration of Drugs at a 48-hour Interval for Medical Abortion, <a href="https://clinicaltrials.gov/show/nct03440866" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Https:<wbr style="display:inline-block"></wbr>​//clinicaltrials<wbr style="display:inline-block"></wbr>​.gov/show/nct03440866</a>, 2018</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparison not in PICO</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ortiz, J., Post-abortion follow-up through SMS: Texting alternatives to unnecessary follow-up visits, International Journal of Gynecology and Obstetrics, 143 (Supplement 3), 54, 2018</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Published as abstract only, not enough information available to ascertain relevance</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paul, M., Iyengar, K., Essen, B., Gemzell-Danielsson, K., Iyengar, S. D., Bring, J., Soni, S., Klingberg-Allvin, M., Acceptability of home-assessment post medical abortion and medical abortion in a low-resource setting in Rajasthan, India. Secondary outcome analysis of a non-inferiority randomized controlled trial, PloS one, 10 (9) (no pagination), 2015</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">In-person assessment did not use ultrasound</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Raymond, E. G., Shochet, T., Blum, J., Sheldon, W. R., Platais, I., Bracken, H., Dabash, R., Weaver, M. A., Ngoc, N. T. N., Blumenthal, P. D., Winikoff, B., Serial multilevel urine pregnancy testing to assess medical abortion outcome: a meta-analysis, Contraception, 95, 442-448, 2017</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Includes non-randomised trials; no new studies identified</td></tr><tr><td headers="hd_h_ch9.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Raymond, E. G., Shochet, T., Bracken, H., Low-sensitivity urine pregnancy testing to assess medical abortion outcome: A systematic review, Contraception., 2018</td><td headers="hd_h_ch9.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Includes non-randomised trials; no new studies identified</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">PICO: population, intervention, comparison and outcomes</p></div></dd></dl></dl></div></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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