162 lines
No EOL
70 KiB
XML
162 lines
No EOL
70 KiB
XML
<?xml version="1.0" encoding="utf-8"?>
|
||
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
||
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
|
||
|
||
<head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
||
<!-- AppResources meta begin -->
|
||
<meta name="paf-app-resources" content="" />
|
||
<script type="text/javascript">var ncbi_startTime = new Date();</script>
|
||
|
||
<!-- AppResources meta end -->
|
||
|
||
<!-- TemplateResources meta begin -->
|
||
<meta name="paf_template" content="" />
|
||
|
||
<!-- TemplateResources meta end -->
|
||
|
||
<!-- Logger begin -->
|
||
<meta name="ncbi_db" content="books" /><meta name="ncbi_pdid" content="book-part" /><meta name="ncbi_acc" content="NBK560815" /><meta name="ncbi_domain" content="statpearls" /><meta name="ncbi_report" content="printable" /><meta name="ncbi_type" content="fulltext" /><meta name="ncbi_objectid" content="" /><meta name="ncbi_pcid" content="/NBK560815/?report=printable" /><meta name="ncbi_app" content="bookshelf" />
|
||
<!-- Logger end -->
|
||
|
||
<title>Acute Stress Disorder - StatPearls - NCBI Bookshelf</title>
|
||
|
||
<!-- AppResources external_resources begin -->
|
||
<link rel="stylesheet" href="/core/jig/1.15.2/css/jig.min.css" /><script type="text/javascript" src="/core/jig/1.15.2/js/jig.min.js"></script>
|
||
|
||
<!-- AppResources external_resources end -->
|
||
|
||
<!-- Page meta begin -->
|
||
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="StatPearls [Internet]" /><meta name="citation_title" content="Acute Stress Disorder" /><meta name="citation_publisher" content="StatPearls Publishing" /><meta name="citation_date" content="2023/07/10" /><meta name="citation_author" content="Mehdi Fanai" /><meta name="citation_author" content="Moien AB Khan" /><meta name="citation_pmid" content="32809650" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK560815/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Acute Stress Disorder" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="StatPearls Publishing" /><meta name="DC.Contributor" content="Mehdi Fanai" /><meta name="DC.Contributor" content="Moien AB Khan" /><meta name="DC.Date" content="2023/07/10" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK560815/" /><meta name="description" content="Acute stress disorder (ASD) was first outlined in 1994 at the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) as a new diagnosis.[1] The reasoning for adding this diagnosis was to provide healthcare services to patients with acute traumas but who were not covered by insurance due to the condition being in its early stage. Second, it was hoped to predict post-traumatic stress disorder (PTSD) development in acute trauma patients to initiate early interventions.[2]" /><meta name="og:title" content="Acute Stress Disorder" /><meta name="og:type" content="book" /><meta name="og:description" content="Acute stress disorder (ASD) was first outlined in 1994 at the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) as a new diagnosis.[1] The reasoning for adding this diagnosis was to provide healthcare services to patients with acute traumas but who were not covered by insurance due to the condition being in its early stage. Second, it was hoped to predict post-traumatic stress disorder (PTSD) development in acute trauma patients to initiate early interventions.[2]" /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK560815/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-statpearls-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/statpearls/article-29538/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK560815/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
|
||
|
||
<!-- Page meta end -->
|
||
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8D26EF7D8468E10000000000FC00E1.m_5" />
|
||
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3985586/3808861/4121862/3974050/3917732/251717/4216701/14534/45193/4113719/3849091/3984811/3751656/4033350/3840896/3577051/3852958/3984801/12930/3964959.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3411343/3882866.css" media="print" /></head>
|
||
<body class="book-part">
|
||
<div class="grid no_max_width">
|
||
<div class="col twelve_col nomargin shadow">
|
||
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
|
||
<div class="sysmessages">
|
||
<noscript>
|
||
<p class="nojs">
|
||
<strong>Warning:</strong>
|
||
The NCBI web site requires JavaScript to function.
|
||
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
||
</p>
|
||
</noscript>
|
||
</div>
|
||
<!--/.sysmessage-->
|
||
<div class="wrap">
|
||
<div class="page">
|
||
<div class="top">
|
||
|
||
<div class="header">
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<!--<component id="Page" label="headcontent"/>-->
|
||
|
||
</div>
|
||
<div class="content">
|
||
<!-- site messages -->
|
||
<div class="container content">
|
||
<div class="document">
|
||
<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. </p></div></div></div>
|
||
<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK560815_"><span class="title" itemprop="name">Acute Stress Disorder</span></h1><p class="contrib-group"><h4>Authors</h4><span itemprop="author">Mehdi Fanai</span><sup>1</sup>; <span itemprop="author">Moien AB Khan</span><sup>2</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup> Johns Hopkins Medicine</div><div class="affiliation"><sup>2</sup> United Arab Emirates University</div><p class="small">Last Update: <span itemprop="dateModified">July 10, 2023</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="article-29538.s1"><h2 id="_article-29538_s1_">Continuing Education Activity</h2><p>Acute stress disorder (ASD) was first outlined in 1994 at the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) as a new diagnosis. This activity describes the evaluation and management of stress disorder and explains the role of the interprofessional team in evaluating and treating patients with this condition.</p><p>
|
||
<b>Objectives:</b>
|
||
<ul><li class="half_rhythm"><div>Identify the etiology of acute stress disorder.</div></li><li class="half_rhythm"><div>Outline the typical presentation of a patient with acute stress disorder.</div></li><li class="half_rhythm"><div>Summarize the management of a patient with acute stress disorder.</div></li><li class="half_rhythm"><div>Explain the importance of improving care coordination among an interprofessional team to improve patient outcomes affected by acute stress disorder (ASD).</div></li></ul>
|
||
<a href="https://www.statpearls.com/account/trialuserreg/?articleid=29538&utm_source=pubmed&utm_campaign=reviews&utm_content=29538" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Access free multiple choice questions on this topic.</a>
|
||
</p></div><div id="article-29538.s2"><h2 id="_article-29538_s2_">Introduction</h2><p>Acute stress disorder (ASD) was first outlined in 1994 at the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) as a new diagnosis.<a class="bk_pop" href="#article-29538.r1">[1]</a> The reasoning for adding this diagnosis was to provide healthcare services to patients with acute traumas but who were not covered by insurance due to the condition being in its early stage. Second, it was hoped to predict post-traumatic stress disorder (PTSD) development in acute trauma patients to initiate early interventions.<a class="bk_pop" href="#article-29538.r2">[2]</a></p><p>ASD explains acute stress reactions (ASRs) that occur in no less than three days and no more than four weeks. In contrast, ASRs that continue for a more extended period than four weeks can meet the criteria for post-traumatic stress disorder (PTSD).<a class="bk_pop" href="#article-29538.r3">[3]</a> ASD was defined in an attempt to describe ASRs that were missed or treated as adjustment disorders.<a class="bk_pop" href="#article-29538.r4">[4]</a> DSM-5 no longer requires dissociative symptoms to diagnose ASD while still including it as a diagnostic criterion.</p><p>With the introduction of the DSM-5 in 2013, multiple changes were made to the diagnostic criteria. ASD was moved from the anxiety disorders bucket to a newly created bucket (i.e., trauma and stressor-related disorders) to distinguish further its characteristics. Unlike DSM-IV, in DSM-V, dissociative symptoms are no longer a requirement for the diagnosis of ASD.<a class="bk_pop" href="#article-29538.r5">[5]</a></p><p>The etiology, epidemiology, pathophysiology, history, physical examination, evaluation, treatment, side effects, prognosis, differential diagnosis, patient education, and enhancing outcomes of the acute stress disorder will be discussed here.</p></div><div id="article-29538.s3"><h2 id="_article-29538_s3_">Etiology</h2><p>According to the survey-based studies, twenty to ninety percent of the general population is exposed to one or more extreme stressful events in their life.<a class="bk_pop" href="#article-29538.r6">[6]</a> Although a large number is exposed, only 1.3 to 11.2 percent of acute stress disorder (ASD) developed long-term symptomatic disease (such as PTSD).</p><p>
|
||
<b>Risk Factors</b>
|
||
</p><p>There is limited evidence on risk factors for developing ASD after a traumatic event. However, the risk factors for PTSD could also be applied to ASD due to its close resemblance. Based on the two metanalyses performed by Ozer et al. and Brewin et al., Sareen J. categorized risk factors in three buckets:<a class="bk_pop" href="#article-29538.r7">[7]</a><a class="bk_pop" href="#article-29538.r8">[8]</a><a class="bk_pop" href="#article-29538.r9">[9]</a></p><ol><li class="half_rhythm"><div>Pretrauma factors: 
|
||
<ol><li class="half_rhythm"><div>Female gender</div></li><li class="half_rhythm"><div>Intellectual disability</div></li><li class="half_rhythm"><div>Lack of education</div></li><li class="half_rhythm"><div>History of traumatic events</div></li><li class="half_rhythm"><div>History of psychiatric disorder(s)</div></li><li class="half_rhythm"><div>Personality disorder(s)</div></li><li class="half_rhythm"><div>Genetics</div></li></ol>
|
||
</div></li><li class="half_rhythm"><div>Peritrauma factors:
|
||
<ol><li class="half_rhythm"><div>Trauma severity</div></li><li class="half_rhythm"><div>Assault</div></li><li class="half_rhythm"><div>Rape</div></li><li class="half_rhythm"><div>Physical injury</div></li></ol>
|
||
</div></li><li class="half_rhythm"><div>Posttrauma factors:
|
||
<ol><li class="half_rhythm"><div>Acute stress disorder (ASD)</div></li><li class="half_rhythm"><div>Tachycardia</div></li><li class="half_rhythm"><div>Poor socioeconomic status</div></li><li class="half_rhythm"><div>Physical pain severity</div></li><li class="half_rhythm"><div>ICU stay</div></li><li class="half_rhythm"><div>Brain injury</div></li><li class="half_rhythm"><div>Dissociative symptoms</div></li><li class="half_rhythm"><div>Disability</div></li><li class="half_rhythm"><div>Subsequent life stress</div></li></ol>
|
||
</div></li></ol></div><div id="article-29538.s4"><h2 id="_article-29538_s4_">Epidemiology</h2><p>Acute stress disorder (ASD) was initially added to the DSM-IV 20 years ago, but there is limited data on its prevalence, especially in the general population. While ASD is a separate diagnosis compared to PTSD, but the difference is limited to the duration of ASR symptoms, making ASD prevalence measurement more complicated. ASD prevalence is highly variable based on the study and nature of the trauma. The prevalence rates of ASD were reported less than one week post-injury at 24.0 to 24.6% and 1 to 2 weeks post-injury at 11.7% to 40.6%.<a class="bk_pop" href="#article-29538.r10">[10]</a></p><p>Furthermore, there have been some epidemiologic studies on specific populations. A meta-analysis performed by Wenjie Dai et al. in 2018 on the prevalence of ASD among road traffic accidents showed a pooled prevalence of 15.81% (95% CI: 8.27-25.14%). Thirteen studies in eight countries pooled a total of 2989 accident patients. The results show the significance of early ASR symptoms in surveillance and therapy.<a class="bk_pop" href="#article-29538.r5">[5]</a> ASD prevalence in emergency room encounters among children (7 to 17 years) exposed to trauma was 14.2 in two weeks. The prevalence of PTSD at nine weeks was 9.6 percent.<a class="bk_pop" href="#article-29538.r11">[11]</a> In the postpartum cross-sectional study, mothers having preterm babies had significantly higher ASD than term babies ( 14.9 % versus 0%, 95% CI: 2.16;617.61, OR: 36.5).<a class="bk_pop" href="#article-29538.r12">[12]</a></p></div><div id="article-29538.s5"><h2 id="_article-29538_s5_">Pathophysiology</h2><p>The exact reason why most people recover after a traumatic event but few develop acute stress disorder (ASD) remains unknown. Various models were developed to explain the response to traumatic events. The majority of them are related to "fear conditioning." It is a form of Pavlovian learning that when a traumatic stimulus (e.g., explosion) occurs together with a neutral stimulus (e.g., smell) or context (e.g., night time), in the future encounters of the neutral stimulus or context, the brain, and the body exhibits the same fear responses (even in the absence of the traumatic stimulus).<a class="bk_pop" href="#article-29538.r13">[13]</a></p><p>Most healthy people adapt to fear conditioning by extinction learning - a gradual reduction in response to the traumatic stimulus. If this mechanism fails, the patient continues to re-experience fearful symptoms of the initial traumatic event.<a class="bk_pop" href="#article-29538.r2">[2]</a></p><p>Functional magnetic resonance imaging (fMRI) scans of PTSD patients have shown hypoactivity of the frontal cortex and hyperactivity of the temporal cortex, demonstrating the possibility of a correlation between PTSD and neural functioning.<a class="bk_pop" href="#article-29538.r14">[14]</a> A more recent study showed hyperactivation of the superior prefrontal and cingulate cortex and medial posterior precuneus.<a class="bk_pop" href="#article-29538.r15">[15]</a></p></div><div id="article-29538.s6"><h2 id="_article-29538_s6_">History and Physical</h2><p>The American psychiatric association, DSM-5 defines acute stress disorder (ASD) criteria as the followings:<a class="bk_pop" href="#article-29538.r16">[16]</a><a class="bk_pop" href="#article-29538.r17">[17]</a></p><ul><li class="half_rhythm"><div>A: Being exposed to a traumatic event (either physically, sexually, or mentally) plus</div></li><li class="half_rhythm"><div>B: Having more than eight of the following symptoms (clustered in five categories) plus:
|
||
<ol><li class="half_rhythm"><div>Intrusion symptoms: 
|
||
<ul><li class="half_rhythm"><div>Distressing memories of the traumatic event are recurrent. Children may have repetitive game plays in themes mimicking the main event.</div></li><li class="half_rhythm"><div>Having repetitive dreams related to the traumatic event. In children, it might be in the form of night terrors.</div></li><li class="half_rhythm"><div>Enactment of the traumatic event recurrence (i.e., flashbacks).</div></li><li class="half_rhythm"><div>Intense or prolonged mental or physicological distress in response to the events or themes reminding the patient of the actual traumatic event.</div></li></ul>
|
||
</div></li><li class="half_rhythm"><div>Negative mood:
|
||
<ul><li class="half_rhythm"><div>Inability to be happy, feel successful or feel love.</div></li></ul>
|
||
</div></li><li class="half_rhythm"><div>Dissociative symptoms:
|
||
<ul><li class="half_rhythm"><div>Having a sense of being detached from self and emotions.</div></li><li class="half_rhythm"><div>Dissociative amnesia (that is not related to intoxication or traumatic brain injury [TBI])</div></li></ul>
|
||
</div></li><li class="half_rhythm"><div>Avoidance symptoms:
|
||
<ul><li class="half_rhythm"><div>Avoidance of thoughts, memories, and feelings about the traumatic event.</div></li><li class="half_rhythm"><div>Avoidance of external reminders of the traumatic event (such as people and places)</div></li></ul>
|
||
</div></li><li class="half_rhythm"><div>Arousal symptoms:
|
||
<ul><li class="half_rhythm"><div>Sleep problems (such as difficulty initiating and maintaining quality sleep)</div></li><li class="half_rhythm"><div>Irritability and rage attacks with minimum to no provocation</div></li><li class="half_rhythm"><div>Highly and abnormally alert to surroundings</div></li><li class="half_rhythm"><div>Distractibility</div></li><li class="half_rhythm"><div>Unusually strong reflexive reactive to a sudden event in the environment</div></li></ul>
|
||
</div></li></ol>
|
||
</div></li><li class="half_rhythm"><div>C, D, and E: Duration of the symptoms should be between three days and four weeks and cause significant functional impairment and not related to substance use or other medical conditions (such as TBI) to meet the criteria for ASD.<a class="bk_pop" href="#article-29538.r16">[16]</a><a class="bk_pop" href="#article-29538.r17">[17]</a></div></li></ul></div><div id="article-29538.s7"><h2 id="_article-29538_s7_">Evaluation</h2><p>Acute stress disorder (ASD) is a psychiatric disorder but still can have physiological manifestations (such as tachycardia) and abnormal fMRI. However, no validated laboratory or radiographic test exists. The diagnosis is clinical and is based on history and physical examination. Careful behavior observation and careful listening to the patient's narrative are of immense value. Many patients are unable to fully reflect their feelings and history in the initial evaluation session and will require additional visits.</p><p>There are validated and quick psychometric questionnaires available that can be used to evaluate ASD children and adults. The Child Stress Reaction Checklist (CSDC), for example, measures symptoms of ASD and PTSD that can be completed in ten minutes. CSDC can be used for children 2 to 18 years old.<a class="bk_pop" href="#article-29538.r18">[18]</a> For adults, there is a questionnaire designed explicitly for ASD (i.e., acute stress disorder scale).<a class="bk_pop" href="#article-29538.r19">[19]</a></p></div><div id="article-29538.s8"><h2 id="_article-29538_s8_">Treatment / Management</h2><p>
|
||
<b>General Measures</b>
|
||
</p><ul><li class="half_rhythm"><div><b>Patient Safety- </b>Making sure that the patient is safe after the traumatic event and knows where to seek help in case of an emergency (food and shelter).<a class="bk_pop" href="#article-29538.r20">[20]</a></div></li><li class="half_rhythm"><div><b>Emotional Support- </b>Patients can receive emotional comfort from close friends or family. In the absence of those, healthcare providers can provide support by explaining the prognosis, course, and coping skills for ASD.</div></li><li class="half_rhythm"><div><b>Practical Support- </b>The process after a traumatic process can be overwhelming. This is because the patient will probably need to help with the police report of the incident, finding a provider, work leave of absence, and health insurance. In case of disability due to an accident, the patient might need further multi-modal medical support as well.</div></li><li class="half_rhythm"><div><b>Followups- </b>Regular visits (for six months) for all patients with a significant traumatic event are recommended.<a class="bk_pop" href="#article-29538.r20">[20]</a></div></li><li class="half_rhythm"><div><b>Suicidality- </b>It is vital to evaluate patients for suicidality in each visit, especially in patients with risk factors for suicide or patients having comorbid psychiatric diseases (such as depression).<a class="bk_pop" href="#article-29538.r21">[21]</a></div></li></ul><p>
|
||
<b>Psychotherapy - </b>Treatment of choice for acute stress disorder (ASD) is a unique form of cognitive-behavioral therapy (CBT) called trauma-focused CBT. CBT can reduce the risk of further developing PTSD.<a class="bk_pop" href="#article-29538.r22">[22]</a> This evidence-based practice can be delivered via the internet, in person, or by phone. It focuses on increasing knowledge on trauma psychology, symptom management skills, identifying and disputing cognitive distortions, and exposure therapy. Exposure therapy is a CBT method that involves controlled patient exposure to the traumatic source to relieve the trauma memory mimicking fear extinction (discussed in the pathophysiology section). Exposure therapy is the standard of care for ASD (and PTSD). A transient worsening of the symptoms can appear, but it is not more common than other intervention methods.<a class="bk_pop" href="#article-29538.r2">[2]</a> Debriefing-which involves asking the patient to explain in detail, the trauma and their feeling about it in the first 72 hours is widely available. studies have not shown the efficacy of debriefing in preventing the development of PTSD, and debriefing is discouraged from routine administration to ASD patients.<a class="bk_pop" href="#article-29538.r23">[23]</a> Crisis intervention method with encouraging patients to avoid maladaptive coping behaviors (such as drinking alcohol).</p><p>
|
||
<b>Pharmacotherapy - </b>Currently, there is no high-quality evidence for a pharmacotherapeutic agent for the treatment of ASD. Serotonin reuptake inhibitors (SRIs) and propranolol were trialed to prevent or treat ASD but were showed little evidence of efficacy.<a class="bk_pop" href="#article-29538.r24">[24]</a><a class="bk_pop" href="#article-29538.r25">[25]</a> Evidence for ASD pharmacotherapy is minimal, and most of the recommendations come from the research on PTSD.<a class="bk_pop" href="#article-29538.r2">[2]</a> Due to similarities between ASD and PTSD and having more RCTs on PTSD, we will review pharmacotherapies for PTSD, which can be applied to ASD. PTSD pharmacotherapy has been more effective in reducing mood symptoms, compared to recurrent memories and avoidance:</p><ul><li class="half_rhythm"><div><b>Serotonin Reuptake Inhibitors (SRIs)- </b>SRIs include Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). SRIs are the most studied medications for the treatment of PTSD with favorable results.<a class="bk_pop" href="#article-29538.r26">[26]</a> For example, paroxetine is FDA approved for the short treatment of PTSD and has shown significant treatment response compared to placebo in three RCTs.<a class="bk_pop" href="#article-29538.r26">[26]</a> Three SSRIs (fluoxetine, sertraline, and paroxetine) and one SNRI (venlafaxine) have the strongest evidence and are first-line pharmacotherapies for the treatment of PTSD.<a class="bk_pop" href="#article-29538.r27">[27]</a></div></li><li class="half_rhythm"><div><b><b>Second-Generation Antipsychotics (SGAs)-</b></b> Can be used either as monotherapy or augmentation with SRIs. Second-generation antipsychotics are not first-line and considered in patients who have limited response to SRIs and CBT, especially in the presence of associated anxiety and depression.<a class="bk_pop" href="#article-29538.r28">[28]</a> Pharmacotherapy should be started with small doses and gradually increased. In the absence of a clinical benefit, it should be gradually discontinued.</div></li><li class="half_rhythm"><div><b>Benzodiazepines-</b> Benzodiazepines are not generally recommended for the treatment of PTSD. Benzodiazepines are ineffective in the prevention or treatment of PTSD. Benzodiazepine prescription is associated with significant adverse effects and worse outcomes and should be relatively contraindicated in PTSD patients.<a class="bk_pop" href="#article-29538.r29">[29]</a><a class="bk_pop" href="#article-29538.r30">[30]</a></div></li><li class="half_rhythm"><div><b>Beta-Blockers-</b> Studies show that propranolol therapy after an acute stressor did not change PTSD incidence but reduced sympathetic symptoms (such as tachycardia and sweating).<a class="bk_pop" href="#article-29538.r25">[25]</a> Current evidence is not strong enough to recommend its routine prescription for PTSD patients.</div></li></ul><p>
|
||
<b>Other Treatments - </b>There is evidence that ECT is beneficial for PTSD patients with concurrent depression with the ability to reduce symptoms for both conditions.<a class="bk_pop" href="#article-29538.r31">[31]</a> It is suggested that one known side effect of ECT (i.e., memory disruption) could be used to help patients with severe PTSD.<a class="bk_pop" href="#article-29538.r31">[31]</a> Clinical trials on mood stabilizers (such as topiramate and tiagabine) are limited in number and quality.<a class="bk_pop" href="#article-29538.r32">[32]</a> Treatment arms were no better than the placebo or had limited effect size.<a class="bk_pop" href="#article-29538.r33">[33]</a> There are cases reports that lamotrigine or gabapentin were effective treatments for PTSD patient nightmares and flashbacks, but more evidence is required to support these medications.<a class="bk_pop" href="#article-29538.r34">[34]</a><a class="bk_pop" href="#article-29538.r33">[33]</a></p><p>
|
||
<b>Symptom Specific Treatments</b>
|
||
</p><ul><li class="half_rhythm"><div><b>Sleep Disturbance-</b> in the form of insomnia and nightmares are common in PTSD. Specific treatment of sleep disturbances might improve other symptoms of PTSD. Multiple studies have evaluated the efficacy of various pharmacotherapies. SRIs and benzodiazepines were not effective. Prazosin, which is an alpha-1 selective adrenergic blocker, has shown efficacy in the management of sleep disturbance in PTSD patients. Other adjuvant treatments, such as eszopiclone, olanzapine, and risperidone, have also been effective.<a class="bk_pop" href="#article-29538.r35">[35]</a></div></li></ul></div><div id="article-29538.s9"><h2 id="_article-29538_s9_">Differential Diagnosis</h2><p>The differential diagnoses of acute stress disorder (ASD) include but are not limited to the following:</p><ul><li class="half_rhythm"><div>PTSD (symptoms last for more than four weeks)</div></li><li class="half_rhythm"><div>Adjustment disorder (does not meet the criteria for ASD)</div></li><li class="half_rhythm"><div>Brief psychotic disorder (also lasts less than four weeks and is stress-related. Symptoms are more generalized and usually less severe).</div></li><li class="half_rhythm"><div>Organic disorder such as mild traumatic brain injury (hard to distinguish based on the neurologic evaluation) or brain tumor (presence of focal neurologic deficit or headaches)</div></li><li class="half_rhythm"><div>Mood disorders such as major depressive disorder (predominance of low mood and depressive symptoms)</div></li></ul></div><div id="article-29538.s10"><h2 id="_article-29538_s10_">Pertinent Studies and Ongoing Trials</h2><p>PTSD psychotherapy is the first-line treatment for PTSD/ASD but is not shown to be very efficacious. The lack of effective therapies continues to make PTSD a chronic illness. Therefore there is an immediate need to explore new compounds and approaches. One promising approach is the use of psychedelics such as ketamine, psilocybin, and 3,4-methylenedioxymethamphetamine (MDMA) to treat PTSD.<a class="bk_pop" href="#article-29538.r36">[36]</a> In recent years, the FDA has approved breakthrough therapy designations for both MDMA and psilocybin to treat PTSD and depression.<a class="bk_pop" href="#article-29538.r36">[36]</a> One MDMA-assisted psychotherapy study is set to get the FDA's approval by 2022.</p></div><div id="article-29538.s11"><h2 id="_article-29538_s11_">Treatment Planning </h2><p>For patients with acute stress disorder (ASD), first-line management would be of trauma-focused cognitive behavioral therapy, as oral therapies have been found to be of limited benefit. Most of the studies on pharmacological treatment have focused on secondary prevention for PTSD rather than focusing on ASD.<a class="bk_pop" href="#article-29538.r37">[37]</a> However, oral medications have been found to be effective in PTSD.</p><p>
|
||
<b>Adult Pharmacotherapy</b>
|
||
</p><p>
|
||
<b>Selective Serotonin Reuptake Inhibitors (SSRIs) -</b> SSRIs such as sertraline, paroxetine, and fluoxetine have been used to treat PTSD. FDA has only approved sertraline and paroxetine.</p><p>Two examples of SSRI pharmacotherapy are provided below:</p><ol><li class="half_rhythm"><div>Fluoxetine: Start with 20 mg/day, PO. If no clinical improvement in a month, gradually increase the initial dose by 5 mg every two to four weeks. The average dose in clinical trials is 40 mg/day. The maximum dose is 80 mg/day PO. Possible to divide the daily dose into two (one in the morning and one in the noon). The highest therapeutic dose tolerable to the patient can be tried for at least six weeks before deciding its efficacy.</div></li><li class="half_rhythm"><div>Paroxetine: Start with 20 mg/day PO. If no clinical improvement in a month, gradually increase the initial dose of 10 mg every two to four weeks. The maximum dose is 60 mg/day. The highest therapeutic dose tolerable to the patient can be tried for at least six weeks before deciding its efficacy.</div></li></ol><p>
|
||
<b>Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) -</b> Venlafaxine (Effexor) extended-release has shown to be effective in PTSD treatment.<a class="bk_pop" href="#article-29538.r38">[38]</a> The extended-release oral form can be started at 37.5 mg once a day. The maximum dose is 300 mg once daily. Dose increases should be based on patient toleration and clinical improvement with no more than 75 mg/day increase in intervals of four or more days.</p><p>
|
||
<b>Second-Generation Antipsychotics (SGAs) - </b>Two antipsychotics with the most clinical evidence are listed below:</p><ol><li class="half_rhythm"><div>Quetiapine monotherapy in an RCT started at 25 mg/day and increased to up to 800 mg/day, PO with an average dose of 258 mg/day. The results showed the clinician-administered PTSD scale (CAPS) as well as re-experiencing and hyperarousal scores in military and non-military cases. The final adjusted dose was 50-800 mg/day, with a patient count of 41. No patient dropouts in the treatment arm were due to inefficacy.<a class="bk_pop" href="#article-29538.r28">[28]</a></div></li><li class="half_rhythm"><div>Risperidone adjunctive therapy, in another RCT, did not show significant results in CAPS scores but showed a small reduction in hyperarousal and re-experiencing scores with a dose of up to 4 mg/day in military cases.<a class="bk_pop" href="#article-29538.r39">[39]</a></div></li></ol><p>
|
||
<b> Alpha-1 Selective Adrenergic Blockers - </b>Prazosin is an antihypertensive medication and works by blocking specific receptors on the vascular smooth muscle. It is thought that prazosin and its metabolites can reduce the overactivation of the sympathetic system in ASD and PTSD. Prazosin can be used as monotherapy or augmentation with an SRI to minimize sleep disturbances mainly.</p><ol><li class="half_rhythm"><div>Prazosin: start at 1 mg, PO at night with monitoring for hypotension (before and after the administration of prazosin). Gradually increase the dose for a final dose of 2 to 6 mg/night.<a class="bk_pop" href="#article-29538.r40">[40]</a></div></li></ol></div><div id="article-29538.s12"><h2 id="_article-29538_s12_">Toxicity and Adverse Effect Management</h2><p>
|
||
<b>SRI Side Effects </b>- SRIs can cause long QT syndrome, SIADH, hyponatremia, suicide ideation (especially in children), seizures, increased risk of bleeding, sexual dysfunction, gastrointestinal symptoms (such as nausea, vomiting, and diarrhea), and serotonin syndrome. SRIs Should be prescribed by a professional and per guidelines.</p><p>Sexual dysfunction in the form of decreased libido, delayed ejaculation, and anorgasmia is common (25% to 73%) among women and men taking SSRIs.<a class="bk_pop" href="#article-29538.r41">[41]</a> Less than 10 percent of patients with sexual dysfunction due to SRIs therapy will improve after continued use of the SRI, and it is suggested to the first wait for up to 8 weeks for improvement. In the case of persistence, careful dose reduction can be tried. If the patient is still symptomatic for sexual side effects and has only partially responded to an SRI, it can be switched to another SRI. Augmentation with bupropion can be tried if the patient has had a good response to the SRI.<a class="bk_pop" href="#article-29538.r42">[42]</a> Please note that sexual dysfunction management recommendations are based on the research of depression treatment and not PTSD and ASD treatment.</p><p>SRIs should not be disconnected abruptly. This is to mitigate withdrawal symptoms.<a class="bk_pop" href="#article-29538.r43">[43]</a></p><p>SRIs can cause mania in patients with bipolar disorder and should not be used in patients with a history of bipolar disorder. In the case of mania, SRI should be discontinued and appropriate bipolar disease therapy initiated. Sleep quality improved in four weeks.</p><p>
|
||
<b>SGA side effects - </b>SGAs can cause long QT syndrome (all SGAs), metabolic syndrome (olanzapine, clozapine), anticholinergic symptoms, and extrapyramidal symptoms (EPS). EPS is less common with SGAs but still can occur:</p><ol><li class="half_rhythm"><div>Acute dystonia</div></li><li class="half_rhythm"><div>Restlessness</div></li><li class="half_rhythm"><div>Parkinsonism</div></li><li class="half_rhythm"><div>Tardive dyskinesia</div></li></ol><p>Risperidone can cause hyperprolactinemia. Clozapine can cause dose-related seizures and dangerous neutropenia. Regularly monitor neutrophil counts before and during the treatment.</p><p>
|
||
<b>Prazosin Side Effects - </b>Prazosin can cause first dose orthostatic hypotension, dizziness, fatigue, and headache. Use caution in patients with hepatic function impairment.</p></div><div id="article-29538.s13"><h2 id="_article-29538_s13_">Prognosis</h2><p>According to one recent study, later development of PTSD is strongly associated with acute stress disorder (ASD). It also showed that an abnormal fMRI is associated with subsequent PTSD severity.<a class="bk_pop" href="#article-29538.r15">[15]</a> According to the DSM-5, PTSD remission occurs within three months in approximately half of the patients. It is recommended to continue pharmacotherapy for more than six months to one year to lessen the risk of relapse.<a class="bk_pop" href="#article-29538.r44">[44]</a> The majority of the patients who developed PTSD recover within the next few years, with a steep decline in the first year. At least one-third of the PTSD patients remain symptomatic for more than two years and are at risk of substance abuse.</p><p>ASD patients are 24 times more likely to die from a suicide attempt compared to those without ASD. One study found that all-cause mortality for patients with a stress disorder diagnosis is two times more than those without.<a class="bk_pop" href="#article-29538.r45">[45]</a></p><p>Avoidance of many conditions that remind the patient of the traumatic event may continue to persist after the initial incident. For example, a car accident patient might avoid driving a car. The patient might lose their job due to abstinence from work or poor work performance. Resulting financial hardships can lead to homelessness in some cases. Social relationships can be limited and lead to break-ups with significant others, which would make the patient's emotional life, even more complicated.</p></div><div id="article-29538.s14"><h2 id="_article-29538_s14_">Complications</h2><p>Acute stress disorder (ASD) can lead to various psychiatric problems:</p><ul><li class="half_rhythm"><div><b>Mood Disorders -</b> Depressive disorders (with or without suicidality), anxiety and panic disorder</div></li><li class="half_rhythm"><div><b>Substance Use Disorders - </b>alcohol use disorder and illicit drug dependence</div></li></ul></div><div id="article-29538.s15"><h2 id="_article-29538_s15_">Deterrence and Patient Education</h2><p>Patient education plays an important role in the management of stress disorders. The patient needs to know that most people will have a strong emotional response, which will resolve in a few days to a week in most cases and will not be chronic. The patients should be advised to avoid scenarios that remind them of the event (such as watching TV shows with a similar theme), spend time with family, and have patience. The patient should be able to actively participate in the treatment planning, therapy options, and significant side effects of therapies.</p></div><div id="article-29538.s16"><h2 id="_article-29538_s16_">Enhancing Healthcare Team Outcomes </h2><p>
|
||
<b>Interprofessional Communication and Social Services - </b>Acute stress disorder (ASD) patients are twenty-four times more likely to die from suicide and have two times more risk of all-cause mortality compared to the general population. ASD can lead to chronic PTSD, which is a debilitating psychiatric disorder. PTSD can significantly affect a patient's quality of life. Due to these risks, managing a traumatic event requires interprofessional care coordination that can involve providers in various disciplines (such as emergency medicine, psychiatry, orthopedics, and neurosurgery), psychologists, nurses, pharmacists, and social workers. Each of these areas will contribute to the overall care plan based on their expertise and engage in open information-sharing regarding the patient's case. </p><p>Interprofessional work can be achieved by respecting the roles of each team member and efficient communication. It is of significant importance due to the affordable care act, which calls for improved care coordination.<a class="bk_pop" href="#article-29538.r46">[46]</a> One example would be social services. Trauma patients require regular follow-ups and most likely require social assistance. Social workers provide mental health services, referral services, care coordination, and follow-up in the case of complex mental and substance use disorders.<a class="bk_pop" href="#article-29538.r46">[46]</a></p><p>In treating acute stress disorder, utilizing the interprofessional model with the various specialties and disciplines mentioned above, patient outcomes are improved while the potential for adverse events and relapse is mitigated. [Level 5]</p></div><div id="article-29538.s17"><h2 id="_article-29538_s17_">Review Questions</h2><ul><li class="half_rhythm"><div>
|
||
<a href="https://www.statpearls.com/account/trialuserreg/?articleid=29538&utm_source=pubmed&utm_campaign=reviews&utm_content=29538" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Access free multiple choice questions on this topic.</a>
|
||
</div></li><li class="half_rhythm"><div>
|
||
<a href="https://mdsearchlight.com/mental-health/acute-stress-disorder/?utm_source=pubmedlink&utm_campaign=MDS&utm_content=29538" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Click here for a simplified version.</a>
|
||
</div></li><li class="half_rhythm"><div>
|
||
<a href="https://www.statpearls.com/articlelibrary/commentarticle/29538/?utm_source=pubmed&utm_campaign=comments&utm_content=29538" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Comment on this article.</a>
|
||
</div></li></ul></div><div id="article-29538.s18"><h2 id="_article-29538_s18_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="article-29538.r1">Bryant RA, Friedman MJ, Spiegel D, Ursano R, Strain J. A review of acute stress disorder in DSM-5. <span><span class="ref-journal">Depress Anxiety. </span>2011 Sep;<span class="ref-vol">28</span>(9):802-17.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21910186" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21910186</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="article-29538.r2">Bryant RA. The Current Evidence for Acute Stress Disorder. <span><span class="ref-journal">Curr Psychiatry Rep. </span>2018 Oct 13;<span class="ref-vol">20</span>(12):111.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/30315408" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30315408</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="article-29538.r3">Bryant RA. Acute stress disorder as a predictor of posttraumatic stress disorder: a systematic review. <span><span class="ref-journal">J Clin Psychiatry. </span>2011 Feb;<span class="ref-vol">72</span>(2):233-9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21208593" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21208593</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="article-29538.r4">Koopman C, Classen C, Cardeña E, Spiegel D. When disaster strikes, acute stress disorder may follow. <span><span class="ref-journal">J Trauma Stress. </span>1995 Jan;<span class="ref-vol">8</span>(1):29-46.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7712057" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7712057</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="article-29538.r5">Dai W, Liu A, Kaminga AC, Deng J, Lai Z, Yang J, Wen SW. Prevalence of acute stress disorder among road traffic accident survivors: a meta-analysis. <span><span class="ref-journal">BMC Psychiatry. </span>2018 Jun 13;<span class="ref-vol">18</span>(1):188.</span> [<a href="/pmc/articles/PMC5998549/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5998549</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29895273" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29895273</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="article-29538.r6">Perrin M, Vandeleur CL, Castelao E, Rothen S, Glaus J, Vollenweider P, Preisig M. Determinants of the development of post-traumatic stress disorder, in the general population. <span><span class="ref-journal">Soc Psychiatry Psychiatr Epidemiol. </span>2014 Mar;<span class="ref-vol">49</span>(3):447-57.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24022753" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24022753</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="article-29538.r7">Sareen J. Posttraumatic stress disorder in adults: impact, comorbidity, risk factors, and treatment. <span><span class="ref-journal">Can J Psychiatry. </span>2014 Sep;<span class="ref-vol">59</span>(9):460-7.</span> [<a href="/pmc/articles/PMC4168808/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4168808</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25565692" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25565692</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="article-29538.r8">Ozer EJ, Best SR, Lipsey TL, Weiss DS. Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis. <span><span class="ref-journal">Psychol Bull. </span>2003 Jan;<span class="ref-vol">129</span>(1):52-73.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12555794" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12555794</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="article-29538.r9">Brewin CR, Andrews B, Valentine JD. Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. <span><span class="ref-journal">J Consult Clin Psychol. </span>2000 Oct;<span class="ref-vol">68</span>(5):748-66.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11068961" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11068961</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="article-29538.r10">Ophuis RH, Olij BF, Polinder S, Haagsma JA. Prevalence of post-traumatic stress disorder, acute stress disorder and depression following violence related injury treated at the emergency department: a systematic review. <span><span class="ref-journal">BMC Psychiatry. </span>2018 Sep 25;<span class="ref-vol">18</span>(1):311.</span> [<a href="/pmc/articles/PMC6156976/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6156976</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/30253782" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30253782</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="article-29538.r11">Meiser-Stedman R, McKinnon A, Dixon C, Boyle A, Smith P, Dalgleish T. Acute stress disorder and the transition to posttraumatic stress disorder in children and adolescents: Prevalence, course, prognosis, diagnostic suitability, and risk markers. <span><span class="ref-journal">Depress Anxiety. </span>2017 Apr;<span class="ref-vol">34</span>(4):348-355.</span> [<a href="/pmc/articles/PMC5381710/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5381710</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28135019" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28135019</span></a>]</div></dd><dt>12.</dt><dd><div class="bk_ref" id="article-29538.r12">Helle N, Barkmann C, Ehrhardt S, Bindt C. Postpartum posttraumatic and acute stress in mothers and fathers of infants with very low birth weight: Cross-sectional results from a controlled multicenter cohort study. <span><span class="ref-journal">J Affect Disord. </span>2018 Aug 01;<span class="ref-vol">235</span>:467-473.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/29679899" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29679899</span></a>]</div></dd><dt>13.</dt><dd><div class="bk_ref" id="article-29538.r13">Johnson LR, McGuire J, Lazarus R, Palmer AA. Pavlovian fear memory circuits and phenotype models of PTSD. <span><span class="ref-journal">Neuropharmacology. </span>2012 Feb;<span class="ref-vol">62</span>(2):638-46.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21782833" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21782833</span></a>]</div></dd><dt>14.</dt><dd><div class="bk_ref" id="article-29538.r14">Geuze E, Vermetten E, Ruf M, de Kloet CS, Westenberg HG. Neural correlates of associative learning and memory in veterans with posttraumatic stress disorder. <span><span class="ref-journal">J Psychiatr Res. </span>2008 Jul;<span class="ref-vol">42</span>(8):659-69.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17698081" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17698081</span></a>]</div></dd><dt>15.</dt><dd><div class="bk_ref" id="article-29538.r15">Cwik JC, Sartory G, Nuyken M, Schürholt B, Seitz RJ. Posterior and prefrontal contributions to the development posttraumatic stress disorder symptom severity: an fMRI study of symptom provocation in acute stress disorder. <span><span class="ref-journal">Eur Arch Psychiatry Clin Neurosci. </span>2017 Sep;<span class="ref-vol">267</span>(6):495-505.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/27455992" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27455992</span></a>]</div></dd><dt>16.</dt><dd><div class="bk_ref" id="article-29538.r16">Regier DA, Kuhl EA, Kupfer DJ. The DSM-5: Classification and criteria changes. <span><span class="ref-journal">World Psychiatry. </span>2013 Jun;<span class="ref-vol">12</span>(2):92-8.</span> [<a href="/pmc/articles/PMC3683251/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3683251</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/23737408" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23737408</span></a>]</div></dd><dt>17.</dt><dd><div class="bk_ref" id="article-29538.r17">Cardeña E, Carlson E. Acute stress disorder revisited. <span><span class="ref-journal">Annu Rev Clin Psychol. </span>2011;<span class="ref-vol">7</span>:245-67.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21275643" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21275643</span></a>]</div></dd><dt>18.</dt><dd><div class="bk_ref" id="article-29538.r18">Saxe G, Chawla N, Stoddard F, Kassam-Adams N, Courtney D, Cunningham K, Lopez C, Hall E, Sheridan R, King D, King L. Child Stress Disorders Checklist: a measure of ASD and PTSD in children. <span><span class="ref-journal">J Am Acad Child Adolesc Psychiatry. </span>2003 Aug;<span class="ref-vol">42</span>(8):972-8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12874500" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12874500</span></a>]</div></dd><dt>19.</dt><dd><div class="bk_ref" id="article-29538.r19">Bryant RA, Moulds ML, Guthrie RM. Acute Stress Disorder Scale: a self-report measure of acute stress disorder. <span><span class="ref-journal">Psychol Assess. </span>2000 Mar;<span class="ref-vol">12</span>(1):61-8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10752364" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10752364</span></a>]</div></dd><dt>20.</dt><dd><div class="bk_ref" id="article-29538.r20">Nash WP, Watson PJ. Review of VA/DOD Clinical Practice Guideline on management of acute stress and interventions to prevent posttraumatic stress disorder. <span><span class="ref-journal">J Rehabil Res Dev. </span>2012;<span class="ref-vol">49</span>(5):637-48.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/23015576" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23015576</span></a>]</div></dd><dt>21.</dt><dd><div class="bk_ref" id="article-29538.r21">Gradus JL, Qin P, Lincoln AK, Miller M, Lawler E, Sørensen HT, Lash TL. Acute stress reaction and completed suicide. <span><span class="ref-journal">Int J Epidemiol. </span>2010 Dec;<span class="ref-vol">39</span>(6):1478-84.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/20624822" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20624822</span></a>]</div></dd><dt>22.</dt><dd><div class="bk_ref" id="article-29538.r22">Kliem S, Kröger C. Prevention of chronic PTSD with early cognitive behavioral therapy. A meta-analysis using mixed-effects modeling. <span><span class="ref-journal">Behav Res Ther. </span>2013 Nov;<span class="ref-vol">51</span>(11):753-61.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24077120" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24077120</span></a>]</div></dd><dt>23.</dt><dd><div class="bk_ref" id="article-29538.r23">Aulagnier M, Verger P, Rouillon F. [Efficiency of psychological debriefing in preventing post-traumatic stress disorders]. <span><span class="ref-journal">Rev Epidemiol Sante Publique. </span>2004 Feb;<span class="ref-vol">52</span>(1):67-79.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15107694" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15107694</span></a>]</div></dd><dt>24.</dt><dd><div class="bk_ref" id="article-29538.r24">Shalev AY, Ankri Y, Israeli-Shalev Y, Peleg T, Adessky R, Freedman S. Prevention of posttraumatic stress disorder by early treatment: results from the Jerusalem Trauma Outreach And Prevention study. <span><span class="ref-journal">Arch Gen Psychiatry. </span>2012 Feb;<span class="ref-vol">69</span>(2):166-76.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21969418" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21969418</span></a>]</div></dd><dt>25.</dt><dd><div class="bk_ref" id="article-29538.r25">Steenen SA, van Wijk AJ, van der Heijden GJ, van Westrhenen R, de Lange J, de Jongh A. Propranolol for the treatment of anxiety disorders: Systematic review and meta-analysis. <span><span class="ref-journal">J Psychopharmacol. </span>2016 Feb;<span class="ref-vol">30</span>(2):128-39.</span> [<a href="/pmc/articles/PMC4724794/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4724794</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26487439" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26487439</span></a>]</div></dd><dt>26.</dt><dd><div class="bk_ref" id="article-29538.r26">Ipser JC, Stein DJ. Evidence-based pharmacotherapy of post-traumatic stress disorder (PTSD). <span><span class="ref-journal">Int J Neuropsychopharmacol. </span>2012 Jul;<span class="ref-vol">15</span>(6):825-40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21798109" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21798109</span></a>]</div></dd><dt>27.</dt><dd><div class="bk_ref" id="article-29538.r27">Bisson JI, Baker A, Dekker W, Hoskins MD. Evidence-based prescribing for post-traumatic stress disorder. <span><span class="ref-journal">Br J Psychiatry. </span>2020 Mar;<span class="ref-vol">216</span>(3):125-126.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/32345407" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32345407</span></a>]</div></dd><dt>28.</dt><dd><div class="bk_ref" id="article-29538.r28">Villarreal G, Hamner MB, Cañive JM, Robert S, Calais LA, Durklaski V, Zhai Y, Qualls C. Efficacy of Quetiapine Monotherapy in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial. <span><span class="ref-journal">Am J Psychiatry. </span>2016 Dec 01;<span class="ref-vol">173</span>(12):1205-1212.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/27418378" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27418378</span></a>]</div></dd><dt>29.</dt><dd><div class="bk_ref" id="article-29538.r29">Guina J, Rossetter SR, DeRHODES BJ, Nahhas RW, Welton RS. Benzodiazepines for PTSD: A Systematic Review and Meta-Analysis. <span><span class="ref-journal">J Psychiatr Pract. </span>2015 Jul;<span class="ref-vol">21</span>(4):281-303.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/26164054" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26164054</span></a>]</div></dd><dt>30.</dt><dd><div class="bk_ref" id="article-29538.r30">Argolo FC, Cavalcanti-Ribeiro P, Netto LR, Quarantini LC. Prevention of posttraumatic stress disorder with propranolol: A meta-analytic review. <span><span class="ref-journal">J Psychosom Res. </span>2015 Aug;<span class="ref-vol">79</span>(2):89-93.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/25972056" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25972056</span></a>]</div></dd><dt>31.</dt><dd><div class="bk_ref" id="article-29538.r31">Kellner CH, Romanella SM. ECT as a Novel Treatment for PTSD. <span><span class="ref-journal">J ECT. </span>2019 Jun;<span class="ref-vol">35</span>(2):e13.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/30113991" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30113991</span></a>]</div></dd><dt>32.</dt><dd><div class="bk_ref" id="article-29538.r32">Davidson JR, Brady K, Mellman TA, Stein MB, Pollack MH. The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder. <span><span class="ref-journal">J Clin Psychopharmacol. </span>2007 Feb;<span class="ref-vol">27</span>(1):85-8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17224720" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17224720</span></a>]</div></dd><dt>33.</dt><dd><div class="bk_ref" id="article-29538.r33">Ralevski E, Olivera-Figueroa LA, Petrakis I. PTSD and comorbid AUD: a review of pharmacological and alternative treatment options. <span><span class="ref-journal">Subst Abuse Rehabil. </span>2014;<span class="ref-vol">5</span>:25-36.</span> [<a href="/pmc/articles/PMC3953034/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3953034</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24648794" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24648794</span></a>]</div></dd><dt>34.</dt><dd><div class="bk_ref" id="article-29538.r34">Kishimoto A, Goto Y, Hashimoto K. Post-traumatic Stress Disorder Symptoms in a Female Patient Following Repeated Teasing: Treatment with Gabapentin and Lamotrigine and the Possible Role of Sensitization. <span><span class="ref-journal">Clin Psychopharmacol Neurosci. </span>2014 Dec;<span class="ref-vol">12</span>(3):240-2.</span> [<a href="/pmc/articles/PMC4293172/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4293172</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25598830" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25598830</span></a>]</div></dd><dt>35.</dt><dd><div class="bk_ref" id="article-29538.r35">Lipinska G, Baldwin DS, Thomas KG. Pharmacology for sleep disturbance in PTSD. <span><span class="ref-journal">Hum Psychopharmacol. </span>2016 Mar;<span class="ref-vol">31</span>(2):156-63.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/26856810" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26856810</span></a>]</div></dd><dt>36.</dt><dd><div class="bk_ref" id="article-29538.r36">Krediet E, Bostoen T, Breeksema J, van Schagen A, Passie T, Vermetten E. Reviewing the Potential of Psychedelics for the Treatment of PTSD. <span><span class="ref-journal">Int J Neuropsychopharmacol. </span>2020 Jun 24;<span class="ref-vol">23</span>(6):385-400.</span> [<a href="/pmc/articles/PMC7311646/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC7311646</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/32170326" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32170326</span></a>]</div></dd><dt>37.</dt><dd><div class="bk_ref" id="article-29538.r37">Howlett JR, Stein MB. Prevention of Trauma and Stressor-Related Disorders: A Review. <span><span class="ref-journal">Neuropsychopharmacology. </span>2016 Jan;<span class="ref-vol">41</span>(1):357-69.</span> [<a href="/pmc/articles/PMC4677144/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4677144</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26315508" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26315508</span></a>]</div></dd><dt>38.</dt><dd><div class="bk_ref" id="article-29538.r38">Davidson J, Baldwin D, Stein DJ, Kuper E, Benattia I, Ahmed S, Pedersen R, Musgnung J. Treatment of posttraumatic stress disorder with venlafaxine extended release: a 6-month randomized controlled trial. <span><span class="ref-journal">Arch Gen Psychiatry. </span>2006 Oct;<span class="ref-vol">63</span>(10):1158-65.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17015818" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17015818</span></a>]</div></dd><dt>39.</dt><dd><div class="bk_ref" id="article-29538.r39">Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C., Veterans Affairs Cooperative Study No. 504 Group. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. <span><span class="ref-journal">JAMA. </span>2011 Aug 03;<span class="ref-vol">306</span>(5):493-502.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21813427" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21813427</span></a>]</div></dd><dt>40.</dt><dd><div class="bk_ref" id="article-29538.r40">Reist C, Streja E, Tang CC, Shapiro B, Mintz J, Hollifield M. Prazosin for treatment of post-traumatic stress disorder: a systematic review and meta-analysis. <span><span class="ref-journal">CNS Spectr. </span>2021 Aug;<span class="ref-vol">26</span>(4):338-344.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/32362287" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32362287</span></a>]</div></dd><dt>41.</dt><dd><div class="bk_ref" id="article-29538.r41">Higgins A, Nash M, Lynch AM. Antidepressant-associated sexual dysfunction: impact, effects, and treatment. <span><span class="ref-journal">Drug Healthc Patient Saf. </span>2010;<span class="ref-vol">2</span>:141-50.</span> [<a href="/pmc/articles/PMC3108697/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3108697</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21701626" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21701626</span></a>]</div></dd><dt>42.</dt><dd><div class="bk_ref" id="article-29538.r42">Bala A, Nguyen HMT, Hellstrom WJG. Post-SSRI Sexual Dysfunction: A Literature Review. <span><span class="ref-journal">Sex Med Rev. </span>2018 Jan;<span class="ref-vol">6</span>(1):29-34.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/28778697" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28778697</span></a>]</div></dd><dt>43.</dt><dd><div class="bk_ref" id="article-29538.r43">Horowitz MA, Taylor D. Tapering of SSRI treatment to mitigate withdrawal symptoms. <span><span class="ref-journal">Lancet Psychiatry. </span>2019 Jun;<span class="ref-vol">6</span>(6):538-546.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/30850328" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30850328</span></a>]</div></dd><dt>44.</dt><dd><div class="bk_ref" id="article-29538.r44">Davis LL, Frazier EC, Williford RB, Newell JM. Long-term pharmacotherapy for post-traumatic stress disorder. <span><span class="ref-journal">CNS Drugs. </span>2006;<span class="ref-vol">20</span>(6):465-76.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16734498" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16734498</span></a>]</div></dd><dt>45.</dt><dd><div class="bk_ref" id="article-29538.r45">Gradus JL, Antonsen S, Svensson E, Lash TL, Resick PA, Hansen JG. Trauma, comorbidity, and mortality following diagnoses of severe stress and adjustment disorders: a nationwide cohort study. <span><span class="ref-journal">Am J Epidemiol. </span>2015 Sep 01;<span class="ref-vol">182</span>(5):451-8.</span> [<a href="/pmc/articles/PMC4552266/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4552266</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26243737" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26243737</span></a>]</div></dd><dt>46.</dt><dd><div class="bk_ref" id="article-29538.r46">Courtenay M, Nancarrow S, Dawson D. Interprofessional teamwork in the trauma setting: a scoping review. <span><span class="ref-journal">Hum Resour Health. </span>2013 Nov 05;<span class="ref-vol">11</span>:57.</span> [<a href="/pmc/articles/PMC3826522/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3826522</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24188523" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24188523</span></a>]</div></dd></dl></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin">
|
||
<b>Disclosure: </b>Mehdi Fanai declares no relevant financial relationships with ineligible companies.</p></div></dd><dt></dt><dd><div><p class="no_top_margin">
|
||
<b>Disclosure: </b>Moien AB Khan declares no relevant financial relationships with ineligible companies.</p></div></dd></dl></div></div></div>
|
||
<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © 2025, StatPearls Publishing LLC.<p class="small">
|
||
This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
|
||
(<a href="https://creativecommons.org/licenses/by-nc-nd/4.0/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=uri">
|
||
http://creativecommons.org/licenses/by-nc-nd/4.0/
|
||
</a>), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not required to obtain permission to distribute this article, provided that you credit the author and journal.
|
||
</p></div><div class="small"><span class="label">Bookshelf ID: NBK560815</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32809650" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">32809650</a></span></div></div></div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="bottom">
|
||
|
||
<div id="NCBIFooter_dynamic">
|
||
<!--<component id="Breadcrumbs" label="breadcrumbs"/>
|
||
<component id="Breadcrumbs" label="helpdesk"/>-->
|
||
|
||
</div>
|
||
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"> </script>
|
||
</div>
|
||
</div>
|
||
<!--/.page-->
|
||
</div>
|
||
<!--/.wrap-->
|
||
</div><!-- /.twelve_col -->
|
||
</div>
|
||
<!-- /.grid -->
|
||
|
||
<span class="PAFAppResources"></span>
|
||
|
||
<!-- BESelector tab -->
|
||
|
||
|
||
|
||
<noscript><img alt="statistics" src="/stat?jsdisabled=true&ncbi_db=books&ncbi_pdid=book-part&ncbi_acc=NBK560815&ncbi_domain=statpearls&ncbi_report=printable&ncbi_type=fulltext&ncbi_objectid=&ncbi_pcid=/NBK560815/?report=printable&ncbi_app=bookshelf" /></noscript>
|
||
|
||
|
||
<!-- usually for JS scripts at page bottom -->
|
||
<!--<component id="PageFixtures" label="styles"></component>-->
|
||
|
||
|
||
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal106 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
||
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
||
|
||
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3879255/4121861/3501987/4008961/3893018/3821238/3400083/3426610.js" snapshot="books"></script></body>
|
||
</html> |