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class="bkr_bib"><h1 id="_NBK559940_"><span itemprop="name">Endoscopic resection alone for early colon cancer</span></h1><div class="subtitle">Colorectal cancer (update)</div><p><b>Evidence review C6</b></p><p><i>NICE Guideline, No. 151</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Guideline Alliance (UK)</span>.</p><div class="half_rhythm">London: <a href="https://www.nice.org.uk" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2020 Jan</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-3657-1</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2020.</div></div><div class="bkr_clear"></div></div><div id="ch8.s1"><h2 id="_ch8_s1_">Endoscopic resection alone for people with early colon cancer</h2><p>No recommendations were made from this evidence review.</p><div id="ch8.s1.1"><h3>Review question</h3><p>Which people with early colon cancer can be treated with endoscopic resection alone?</p><div id="ch8.s1.1.1"><h4>Introduction</h4><p>Increasing use of endoscopy for the resection of polyps has led to improvements in the detection of early colorectal cancer and an increase in the numbers of people identified as having malignant polyps. However, malignancy is not usually confirmed until a histological examination of the resected polyp has been conducted. For some people, subsequent resection of the bowel will be required, whereas for others a ‘watch and wait’ strategy may be sufficient. There is a lack of clarity on which people should go on to have a bowel resection after endoscopy as it is not clear in which groups this will lead to improved survival. Therefore, the objective of this review was to determine which people with early colon cancer can be treated with endoscopic resection alone.</p></div><div id="ch8.s1.1.2"><h4>Summary of the protocol</h4><p>Please see <a class="figpopup" href="/books/NBK559940/table/ch8.tab1/?report=objectonly" target="object" rid-figpopup="figch8tab1" rid-ob="figobch8tab1">Table 1</a> for a summary of the population, intervention, comparison and outcome- (PICO) characteristics of this review.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch8tab1"><a href="/books/NBK559940/table/ch8.tab1/?report=objectonly" target="object" title="Table 1" class="img_link icnblk_img figpopup" rid-figpopup="figch8tab1" rid-ob="figobch8tab1"><img class="small-thumb" src="/books/NBK559940/table/ch8.tab1/?report=thumb" src-large="/books/NBK559940/table/ch8.tab1/?report=previmg" alt="Table 1. Summary of the protocol (PICO table)." /></a><div class="icnblk_cntnt"><h4 id="ch8.tab1"><a href="/books/NBK559940/table/ch8.tab1/?report=objectonly" target="object" rid-ob="figobch8tab1">Table 1</a></h4><p class="float-caption no_bottom_margin">Summary of the protocol (PICO table). </p></div></div><p>For further details see the review protocol in <a href="#ch8.appa">appendix A</a>.</p></div><div id="ch8.s1.1.3"><h4>Methods and process</h4><p>This evidence review was developed using the methods and process described in <a href="https://www.nice.org.uk/process/pmg20/chapter/introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>
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<u>2014</u>. Methods specific to this review question are described in the review protocol in <a href="#ch8.appa">appendix A</a>.</p><p>Declarations of interest were recorded according to NICE’s 2014 conflicts of interest policy until 31 March 2018. From 1 April 2018, declarations of interest were recorded according to NICE’s 2018 <a href="https://www.nice.org.uk/about/who-we-are/policies-and-procedures" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">conflicts of interest policy</a>. Those interests declared until April 2018 were reclassified according to NICE’s 2018 conflicts of interest policy (see Register of Interests).</p></div><div id="ch8.s1.1.4"><h4>Clinical evidence</h4><div id="ch8.s1.1.4.1"><h5>Included studies</h5><p>Four observational studies were included in this review (<a class="bibr" href="#ch8.s1.1.ref1" rid="ch8.s1.1.ref1">Kouyama 2018</a>; <a class="bibr" href="#ch8.s1.1.ref2" rid="ch8.s1.1.ref2">Levic 2018</a>; <a class="bibr" href="#ch8.s1.1.ref3" rid="ch8.s1.1.ref3">Tamaru 2017</a>; <a class="bibr" href="#ch8.s1.1.ref4" rid="ch8.s1.1.ref4">Yoshii 2014</a>).</p><p>The included studies are summarised in <a class="figpopup" href="/books/NBK559940/table/ch8.tab2/?report=objectonly" target="object" rid-figpopup="figch8tab2" rid-ob="figobch8tab2">Table 2</a>.</p><p>The studies compared endoscopic resection alone to endoscopic resection plus surgery.</p><p>See the literature search strategy in <a href="#ch8.appb">appendix B</a> and study selection flow chart in <a href="#ch8.appc">appendix C</a>.</p></div><div id="ch8.s1.1.4.2"><h5>Excluded studies</h5><p>Studies not included in this review with reasons for their exclusions are provided in <a href="#ch8.appk">appendix K</a>.</p></div></div><div id="ch8.s1.1.5"><h4>Summary of clinical studies included in the evidence review</h4><p>Summaries of the studies that were included in this review are presented in <a class="figpopup" href="/books/NBK559940/table/ch8.tab2/?report=objectonly" target="object" rid-figpopup="figch8tab2" rid-ob="figobch8tab2">Table 2</a>.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch8tab2"><a href="/books/NBK559940/table/ch8.tab2/?report=objectonly" target="object" title="Table 2" class="img_link icnblk_img figpopup" rid-figpopup="figch8tab2" rid-ob="figobch8tab2"><img class="small-thumb" src="/books/NBK559940/table/ch8.tab2/?report=thumb" src-large="/books/NBK559940/table/ch8.tab2/?report=previmg" alt="Table 2. Summary of included studies." /></a><div class="icnblk_cntnt"><h4 id="ch8.tab2"><a href="/books/NBK559940/table/ch8.tab2/?report=objectonly" target="object" rid-ob="figobch8tab2">Table 2</a></h4><p class="float-caption no_bottom_margin">Summary of included studies. </p></div></div><p>See the full evidence tables in <a href="#ch8.appd">appendix D</a> and the forest plots in <a href="#ch8.appe">appendix E</a>.</p></div><div id="ch8.s1.1.6"><h4>Quality assessment of clinical outcomes included in the evidence review</h4><p>See the clinical evidence profiles in <a href="#ch8.appf">appendix F</a>.</p></div><div id="ch8.s1.1.7"><h4>Economic evidence</h4><div id="ch8.s1.1.7.1"><h5>Included studies</h5><p>A systematic review of the economic literature was conducted but no economic studies were identified which were applicable to this review question.</p></div><div id="ch8.s1.1.7.2"><h5>Excluded studies</h5><p>A global search of economic evidence was undertaken for all review questions in this guideline. See Supplement 2 for further information.</p></div></div><div id="ch8.s1.1.8"><h4>Economic model</h4><p>No economic modelling was undertaken for this review because the committee agreed that other topics were higher priorities for economic evaluation.</p></div><div id="ch8.s1.1.9"><h4>Evidence statements</h4><div id="ch8.s1.1.9.1"><h5>Clinical evidence statements</h5><div id="ch8.s1.1.9.1.1"><h5>Comparison 1: Endoscopic resection alone versus endoscopic resection plus surgery</h5><div id="ch8.s1.1.9.1.1.1"><h5>Critical outcomes</h5><div id="ch8.s1.1.9.1.1.1.1"><h5>Overall survival</h5><ul id="ch8.l9"><li id="ch8.lt29" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=304) showed no clinically important difference in overall survival between those receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div><div id="ch8.s1.1.9.1.1.1.2"><h5>Local recurrence</h5><div id="ch8.s1.1.9.1.1.1.2.1"><h5>All patients</h5><ul id="ch8.l10"><li id="ch8.lt30" class="half_rhythm"><div>Very low quality evidence from 3 retrospective cohort studies (N=1399) showed a clinically important increased risk of local recurrence in those receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div><div id="ch8.s1.1.9.1.1.1.2.2"><h5>Low risk patients</h5><ul id="ch8.l11"><li id="ch8.lt31" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=164) showed no clinically important difference in local recurrence between low risk patients receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div><div id="ch8.s1.1.9.1.1.1.2.3"><h5>High risk patients</h5><ul id="ch8.l12"><li id="ch8.lt32" class="half_rhythm"><div>Very low quality evidence from 2 retrospective cohort studies (N=386) was inconsistent about the effect of ER alone compared to ER + surgery on local recurrence. One study showed a clinically important increased risk of in local recurrence in high risk patients receiving ER alone compared to those receiving ER + surgery, but the other showed no difference.</div></li></ul></div></div><div id="ch8.s1.1.9.1.1.1.3"><h5>Disease free survival</h5><div id="ch8.s1.1.9.1.1.1.3.1"><h5>All patients</h5><ul id="ch8.l13"><li id="ch8.lt33" class="half_rhythm"><div>Very low quality evidence from 2 retrospective cohort studies (N=1234) showed no clinically important difference in disease free survival between those receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div><div id="ch8.s1.1.9.1.1.1.3.2"><h5>Low risk patients</h5><ul id="ch8.l14"><li id="ch8.lt34" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=164) showed no clinically important difference in disease free survival between low risk patients receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div><div id="ch8.s1.1.9.1.1.1.3.3"><h5>High risk patients</h5><ul id="ch8.l15"><li id="ch8.lt35" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=112) showed no clinically important difference in disease free survival between high risk patients receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div></div></div><div id="ch8.s1.1.9.1.1.2"><h5>Important outcomes</h5><div id="ch8.s1.1.9.1.1.2.1"><h5>Quality of life</h5><p>No evidence was identified to inform this outcome.</p></div><div id="ch8.s1.1.9.1.1.2.2"><h5>Distant metastasis</h5><div id="ch8.s1.1.9.1.1.2.2.1"><h5>All patients</h5><ul id="ch8.l16"><li id="ch8.lt36" class="half_rhythm"><div>Very low quality evidence from 3 retrospective cohort studies (N=1389) showed no clinically important difference in distant metastasis between those receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div><div id="ch8.s1.1.9.1.1.2.2.2"><h5>Low risk patients</h5><ul id="ch8.l17"><li id="ch8.lt37" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=164) showed no clinically important difference in distant metastasis between low risk patients receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div><div id="ch8.s1.1.9.1.1.2.2.3"><h5>High risk patients</h5><ul id="ch8.l18"><li id="ch8.lt38" class="half_rhythm"><div>Very low quality evidence from 2 retrospective cohort studies (N=386) showed no clinically important difference in distant metastasis between high risk patients receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div></div><div id="ch8.s1.1.9.1.1.2.3"><h5>Treatment-related morbidity</h5><ul id="ch8.l19"><li id="ch8.lt39" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=304) showed a clinically important reduction in intraoperative surgical complications in those receiving ER alone compared to those receiving ER + surgery.</div></li><li id="ch8.lt40" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=304) showed a clinically important reduction in postoperative surgical complications in those receiving ER alone compared to those receiving ER + surgery.</div></li><li id="ch8.lt41" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=304) showed a clinically important reduction in postoperative medical complications in those receiving ER alone compared to those receiving ER + surgery.</div></li><li id="ch8.lt42" class="half_rhythm"><div>Very low quality evidence from 1 retrospective cohort study (N=304) showed a clinically important reduction in grade 3 or 4 complications in those receiving ER alone compared to those receiving ER + surgery.</div></li></ul></div></div></div></div><div id="ch8.s1.1.9.2"><h5>Economic evidence statements</h5><p>No economic evidence was identified which was applicable to this review question.</p></div></div><div id="ch8.s1.1.10"><h4>The committee’s discussion of the evidence</h4><div id="ch8.s1.1.10.1"><h5>Interpreting the evidence</h5><div id="ch8.s1.1.10.1.1"><h5>The outcomes that matter most</h5><p>Disease-free survival and overall survival were considered critical outcomes for decision-making because the aim of cancer treatment is to control the disease and improve survival.</p><p>Local recurrence and distant metastasis were critical outcomes because they typically lead to further treatment with associated treatment related adverse effects and because they indicate that the disease was not controlled by the surgical treatment.</p><p>Quality of life was an important outcome because of the impact that different treatment options can have on patients’ functioning and their potential long term adverse effects. Treatment-related mortality was identified as an important outcome because it is indicative of the short-term side effects of treatment.</p></div><div id="ch8.s1.1.10.1.2"><h5>The quality of the evidence</h5><p>Evidence was available for the comparison of endoscopic resection alone versus endoscopic resection + surgery. Evidence was available for all of the outcomes except quality of life. The quality of the clinical evidence was assessed using GRADE and was of very low quality.</p><p>The quality of evidence was downgraded because of methodological limitations affecting the risk of bias and imprecision in the risk estimate. Indirectness was also an issue as all four studies included patients with tumours located in the rectum. Uncertainty around the risk estimate was generally attributable to low event rates and small sample sizes.</p></div><div id="ch8.s1.1.10.1.3"><h5>Benefits and harms</h5><p>The low quality of the evidence and lack of evidence for some comparisons and outcomes impacted the decision-making and the strength of the recommendations as there was insufficient evidence to recommend one type of treatment over another.</p><p>The committee agreed that they were unable to make any recommendations due to the very low quality of the studies reviewed and the inclusion of both high and low risk patients in a number of samples.</p><p>The committee discussed current practice and noted that risk scoring systems (using histopathological criteria) were already well established and had been disseminated by organisations such as the British Society of Gastroenterology and the Association of Coloproctology for Great Britain and Ireland.</p><p>The committee went on to discuss the expansion of research into the genetic markers of recurrence and the benefit that this was likely to have on treatment decision-making. It was agreed that if this guideline were to be updated in future this question might be better addressed through a review of predictive studies focusing on the biomarkers of recurrence. As a result of this discussion the committee agreed that it would not be appropriate to draft a research recommendation in relation to this review.</p></div></div><div id="ch8.s1.1.10.2"><h5>Cost effectiveness and resource use</h5><p>A systematic review of the economic literature was conducted but no relevant studies were identified which were applicable to this review question.</p></div></div><div id="ch8.rl.r1"><h4>References</h4><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch8.s1.1.ref1"><p id="p-95">
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<strong>Kouyama 2018</strong>
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</p>Kouyama
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Y, Kudo
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S, Miyachi
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H, et al. (2018) Risk factors of recurrence in T1 colorectal cancers treated by endoscopic resection alone or surgical resection with lymph node dissection. International Journal of Colorectal Disease
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33(8): 1029–1038 [<a href="https://pubmed.ncbi.nlm.nih.gov/29748707" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29748707</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch8.s1.1.ref2"><p id="p-96">
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<strong>Levic 2018</strong>
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</p>Levic
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K, Bulut
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O, Hansen
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T, et al. (2018) Malignant colorectal polyps: endoscopic polypectomy and watchful waiting is not inferior to subsequent bowel resection. A nationwide propensity score-based analysis. Langenbeck’s Archives of Surgery
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404(2): 231–242 [<a href="https://pubmed.ncbi.nlm.nih.gov/30206683" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30206683</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch8.s1.1.ref3"><p id="p-97">
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<strong>Tamaru 2017</strong>
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</p>Tamaru
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Y, Oka
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S, Tanaka
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S, et al. (2017) Long-term outcomes after treatment for T1 colorectal carcinoma: a multicenter retrospective cohort study of Hiroshima GI Endoscopy Research Group. Journal of Gastroenterology
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52(11): 1169–1179 [<a href="https://pubmed.ncbi.nlm.nih.gov/28194526" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28194526</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch8.s1.1.ref4"><p id="p-98">
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<strong>Yoshii 2014</strong>
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</p>Yoshii
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S, Nojima
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M, Nosho
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K, et al. (2014) Factors associated with risk for colorectal cancer recurrence after endoscopic resection of T1 tumors, Clinical Gastroenterology and 3 Hepatology
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12(2): 292–302 [<a href="https://pubmed.ncbi.nlm.nih.gov/23962552" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23962552</span></a>]</div></p></li></ul></div></div></div><div id="appendixesappgroup8"><h2 id="_appendixesappgroup8_">Appendices</h2><div id="ch8.appa"><h3>Appendix A. Review protocol</h3><div id="ch8.appa.s1"><h4>Review protocol for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p id="ch8.appa.tab1"><a href="/books/NBK559940/table/ch8.appa.tab1/?report=objectonly" target="object" rid-ob="figobch8appatab1" class="figpopup">Table 3. Review protocol for endoscopic resection alone for early colon cancer</a></p></div></div><div id="ch8.appb"><h3>Appendix B. Literature search strategies</h3><div id="ch8.appb.s1"><h4>Literature search strategies for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><div id="ch8.appb.s1.1"><h5>Databases: Embase/Medline</h5><p>Last searched on: 09/11/2018</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch8appbtab1"><a href="/books/NBK559940/table/ch8.appb.tab1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch8appbtab1" rid-ob="figobch8appbtab1"><img class="small-thumb" src="/books/NBK559940/table/ch8.appb.tab1/?report=thumb" src-large="/books/NBK559940/table/ch8.appb.tab1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch8.appb.tab1"><a href="/books/NBK559940/table/ch8.appb.tab1/?report=objectonly" target="object" rid-ob="figobch8appbtab1">Table</a></h4></div></div></div><div id="ch8.appb.s1.2"><h5>Database: Cochrane Library</h5><p>Last searched on: 12/11/2018</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch8appbtab2"><a href="/books/NBK559940/table/ch8.appb.tab2/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch8appbtab2" rid-ob="figobch8appbtab2"><img class="small-thumb" src="/books/NBK559940/table/ch8.appb.tab2/?report=thumb" src-large="/books/NBK559940/table/ch8.appb.tab2/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch8.appb.tab2"><a href="/books/NBK559940/table/ch8.appb.tab2/?report=objectonly" target="object" rid-ob="figobch8appbtab2">Table</a></h4></div></div></div></div></div><div id="ch8.appc"><h3>Appendix C. Clinical evidence study selection</h3><div id="ch8.appc.s1"><h4>Clinical study selection for: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p id="ch8.appc.fig1"><a href="/books/NBK559940/figure/ch8.appc.fig1/?report=objectonly" target="object" rid-ob="figobch8appcfig1" class="figpopup">Figure 1. Study selection flow chart</a></p></div></div><div id="ch8.appd"><h3>Appendix D. Clinical evidence tables</h3><div id="ch8.appd.s1"><h4>Clinical evidence tables for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p id="ch8.appd.et1"><a href="/books/NBK559940/bin/ch8-appd-et1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Table 4. Clinical evidence tables</a><span class="small"> (PDF, 463K)</span></p></div></div><div id="ch8.appe"><h3>Appendix E. Forest plots</h3><div id="ch8.appe.s1"><h4>Forest plots for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p id="ch8.appe.fig1"><a href="/books/NBK559940/figure/ch8.appe.fig1/?report=objectonly" target="object" rid-ob="figobch8appefig1" class="figpopup">Figure 2. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - overall survival</a></p><p id="ch8.appe.fig2"><a href="/books/NBK559940/figure/ch8.appe.fig2/?report=objectonly" target="object" rid-ob="figobch8appefig2" class="figpopup">Figure 3. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - local recurrence in all patients and in low risk patients</a></p><p id="ch8.appe.fig3"><a href="/books/NBK559940/figure/ch8.appe.fig3/?report=objectonly" target="object" rid-ob="figobch8appefig3" class="figpopup">Figure 4. Comparison 1: endoscopic resection only versus endoscopic resection + surgery, outcome - local recurrence in high risk patients</a></p><p id="ch8.appe.fig4"><a href="/books/NBK559940/figure/ch8.appe.fig4/?report=objectonly" target="object" rid-ob="figobch8appefig4" class="figpopup">Figure 5. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - disease free survival</a></p><p id="ch8.appe.fig5"><a href="/books/NBK559940/figure/ch8.appe.fig5/?report=objectonly" target="object" rid-ob="figobch8appefig5" class="figpopup">Figure 6. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - distant metastasis</a></p><p id="ch8.appe.fig6"><a href="/books/NBK559940/figure/ch8.appe.fig6/?report=objectonly" target="object" rid-ob="figobch8appefig6" class="figpopup">Figure 7. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - treatment-related morbidity</a></p></div></div><div id="ch8.appf"><h3>Appendix F. GRADE tables</h3><div id="ch8.appf.s1"><h4>GRADE tables for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p id="ch8.appf.tab1"><a href="/books/NBK559940/table/ch8.appf.tab1/?report=objectonly" target="object" rid-ob="figobch8appftab1" class="figpopup">Table 5. Clinical evidence profile for comparison 1: endoscopic resection alone versus endoscopic resection + surgery</a></p></div></div><div id="ch8.appg"><h3>Appendix G. Economic evidence study selection</h3><div id="ch8.appg.s1"><h4>Economic evidence study selection for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p>A global search of economic evidence was undertaken for all review questions in this 5 guideline. See Supplement 2 for further information.</p></div></div><div id="ch8.apph"><h3>Appendix H. Economic evidence tables</h3><div id="ch8.apph.s1"><h4>Economic evidence tables for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p>No economic evidence was identified which was applicable to this review question.</p></div></div><div id="ch8.appi"><h3>Appendix I. Economic evidence profiles</h3><div id="ch8.appi.s1"><h4>Economic evidence profiles for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p>No economic evidence was identified which was applicable to this review question.</p></div></div><div id="ch8.appj"><h3>Appendix J. Economic analysis</h3><div id="ch8.appj.s1"><h4>Economic evidence analysis for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p>No economic analysis was conducted for this review question.</p></div></div><div id="ch8.appk"><h3>Appendix K. Excluded studies</h3><div id="ch8.appk.s1"><h4>Excluded clinical studies for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p id="ch8.appk.tab1"><a href="/books/NBK559940/table/ch8.appk.tab1/?report=objectonly" target="object" rid-ob="figobch8appktab1" class="figpopup">Table 6. Excluded studies and reasons for their exclusion</a></p></div></div><div id="ch8.appl"><h3>Appendix L. Research recommendations</h3><div id="ch8.appl.s1"><h4>Research recommendations for review question: Which people with early colon cancer can be treated with endoscopic resection alone?</h4><p>No research recommendations were made for this review question.</p></div></div></div></div><div class="fm-sec"><div><p>Final</p></div><div><p>Evidence reviews</p><p>Developed by the National Guideline Alliance part of the Royal College of Obstetricians and Gynaecologists</p></div><div><p><b>Disclaimer</b>: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.</p><p>Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.</p><p>NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the <a href="http://wales.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Welsh Government</a>, <a href="http://www.scotland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Scottish Government</a>, and <a href="http://www.northernireland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Northern Ireland Executive</a>. All NICE guidance is subject to regular review and may be updated or withdrawn.</p></div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2020.</div><div class="small"><span class="label">Bookshelf ID: NBK559940</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32729996" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">32729996</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article><article data-type="table-wrap" id="figobch8tab1"><div id="ch8.tab1" class="table"><h3><span class="label">Table 1</span><span class="title">Summary of the protocol (PICO table)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK559940/table/ch8.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch8.tab1_lrgtbl__"><table class="no_bottom_margin"><tbody><tr><th id="hd_b_ch8.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><td headers="hd_b_ch8.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<p>Adults after endoscopic resection of a pedunculated or sessile polyp with invasive cancer.</p>
|
|
<p>Early colon cancer defined as:
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|
<ul id="ch8.l1"><li id="ch8.lt1" class="half_rhythm"><div>T1</div></li><li id="ch8.lt2" class="half_rhythm"><div>N0</div></li><li id="ch8.lt3" class="half_rhythm"><div>M0</div></li></ul>
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<u>Subgroups (analysed separately):</u>
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|
<ul id="ch8.l2"><li id="ch8.lt4" class="half_rhythm"><div>sessile versus pedunculated tumour/polyp</div></li><li id="ch8.lt5" class="half_rhythm"><div>single versus fragmented specimen</div></li><li id="ch8.lt6" class="half_rhythm"><div>low grade tumours (grade 1) versus high grade (grade 2 or 3)</div></li><li id="ch8.lt7" class="half_rhythm"><div>lymphovascular infiltration</div></li><li id="ch8.lt8" class="half_rhythm"><div>positive versus negative resection margin</div></li><li id="ch8.lt9" class="half_rhythm"><div>Haggitt or kikuchi level</div></li></ul></p>
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</td></tr><tr><th id="hd_b_ch8.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention</th><td headers="hd_b_ch8.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Observation/deferred of surgery</td></tr><tr><th id="hd_b_ch8.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparison</th><td headers="hd_b_ch8.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Further surgical resection</td></tr><tr><th id="hd_b_ch8.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes</th><td headers="hd_b_ch8.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Critical</b>
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<ul id="ch8.l3"><li id="ch8.lt10" class="half_rhythm"><div>Overall survival</div></li><li id="ch8.lt11" class="half_rhythm"><div>Local recurrence</div></li><li id="ch8.lt12" class="half_rhythm"><div>Disease-free survival</div></li></ul>
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<b>Important</b>
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<ul id="ch8.l4"><li id="ch8.lt13" class="half_rhythm"><div>Quality of life</div></li><li id="ch8.lt14" class="half_rhythm"><div>Distant metastasis</div></li><li id="ch8.lt15" class="half_rhythm"><div>Treatment-related morbidity</div></li></ul></td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">TNM: cancer classification system, standing for tumour, nodal and metastasis stages</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch8tab2"><div id="ch8.tab2" class="table"><h3><span class="label">Table 2</span><span class="title">Summary of included studies</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK559940/table/ch8.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch8.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch8.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch8.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Population</th><th id="hd_h_ch8.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Intervention/comparison</th><th id="hd_h_ch8.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Outcomes</th></tr></thead><tbody><tr><td headers="hd_h_ch8.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>
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<a class="bibr" href="#ch8.s1.1.ref1" rid="ch8.s1.1.ref1">Kouyama 2018</a>
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</p>
|
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<p>Retrospective cohort study</p>
|
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<p>Japan</p>
|
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</td><td headers="hd_h_ch8.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N= 930 T1 colorectal cancer patients treated by ER or ER and surgical resection (with lymph node dissection)</td><td headers="hd_h_ch8.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ER only versus ER + surgery with lymph node dissection</td><td headers="hd_h_ch8.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<ul id="ch8.l5"><li id="ch8.lt16" class="half_rhythm"><div>Local recurrence</div></li><li id="ch8.lt17" class="half_rhythm"><div>Disease-free survival</div></li><li id="ch8.lt18" class="half_rhythm"><div>Distant metastasis</div></li></ul>
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</td></tr><tr><td headers="hd_h_ch8.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>
|
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<a class="bibr" href="#ch8.s1.1.ref2" rid="ch8.s1.1.ref2">Levic 2018</a>
|
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</p>
|
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<p>Retrospective cohort study</p>
|
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<p>Denmark</p>
|
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</td><td headers="hd_h_ch8.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N=304 (after propensity score matching) patients with colorectal cancer with a malignant colorectal polyp with submucosal invasion completely resected at a primary endoscopic procedure.</td><td headers="hd_h_ch8.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Polypectomy only (i.e. patients for whom it was decided not to perform subsequent bowel resection due to confirmed histological diagnosis of a malignant polyp) versus polypectomy + bowel resection.</td><td headers="hd_h_ch8.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<ul id="ch8.l6"><li id="ch8.lt19" class="half_rhythm"><div>Overall survival</div></li><li id="ch8.lt20" class="half_rhythm"><div>Local recurrence</div></li><li id="ch8.lt21" class="half_rhythm"><div>Disease-free survival</div></li><li id="ch8.lt22" class="half_rhythm"><div>Distant metastasis</div></li><li id="ch8.lt23" class="half_rhythm"><div>Treatment-related morbidity</div></li></ul>
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</td></tr><tr><td headers="hd_h_ch8.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>
|
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<a class="bibr" href="#ch8.s1.1.ref3" rid="ch8.s1.1.ref3">Tamaru 2017</a>
|
|
</p>
|
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<p>Retrospective cohort study</p>
|
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<p>Japan</p>
|
|
</td><td headers="hd_h_ch8.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N=359 T1 colorectal cancer patients treated between January 1992 and December 2008 at Hiroshima University Hospital and 10 affiliated hospitals (Hiroshima Gastrointestinal Endoscopy Research Group) and followed up for >5 years.</td><td headers="hd_h_ch8.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ER (e.g. polypectomy, EMR, ESD) alone versus ER + surgery (indication for additional surgery was determined according to Japanese Classification of Colorectal Carcinoma guidelines.)</td><td headers="hd_h_ch8.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch8.l7"><li id="ch8.lt24" class="half_rhythm"><div>Local recurrence</div></li><li id="ch8.lt25" class="half_rhythm"><div>Distant metastasis</div></li></ul>
|
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</td></tr><tr><td headers="hd_h_ch8.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>
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<a class="bibr" href="#ch8.s1.1.ref4" rid="ch8.s1.1.ref4">Yoshii 2014</a>
|
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</p>
|
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<p>Retrospective cohort study</p>
|
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<p>Japan</p>
|
|
</td><td headers="hd_h_ch8.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N=389 patients with histologically confirmed T1 colorectal cancer (defined as carcinoma that only invaded submucosa, corresponding to a T1 lesion under the American Joint Committee on Cancer classification guidelines.)</td><td headers="hd_h_ch8.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ER (e.g. snare polypectomy, EMR) alone versus ER + surgery (defined as radical resection (e.g. bowel resection) and regional lymph node dissection). Patients were selected for subsequent surgery on the basis of risk factors according to Japanese Society for Cancer of the Colon and Rectum criteria.</td><td headers="hd_h_ch8.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch8.l8"><li id="ch8.lt26" class="half_rhythm"><div>Local recurrence</div></li><li id="ch8.lt27" class="half_rhythm"><div>Disease-free survival</div></li><li id="ch8.lt28" class="half_rhythm"><div>Distant metastasis</div></li></ul>
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</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">EMR: endoscopic mucosal resection; ER: endoscopic resection; ESD: endoscopic submucosal dissection; T: tumour stage</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch8appatab1"><div id="ch8.appa.tab1" class="table"><h3><span class="label">Table 3</span><span class="title">Review protocol for endoscopic resection alone for early colon cancer</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK559940/table/ch8.appa.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch8.appa.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Field (based on <a href="http://www.prisma-statement.org/Extensions/Protocols.aspx" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PRISMA-P</a>)</th><th id="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Content</th></tr></thead><tbody><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review question</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Which people with early colon cancer can be treated with endoscopic resection alone?</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Type of review question</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objective of the review</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To determine which people with early colon cancer can be treated with endoscopic resection alone.</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – population/disease/condition/issue/domain</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>Adults after endoscopic resection of a pedunculated or sessile polyp with invasive cancer</p>
|
|
<p>Early colon cancer defined as:
|
|
<ul id="ch8.l20"><li id="ch8.lt43" class="half_rhythm"><div>T1</div></li><li id="ch8.lt44" class="half_rhythm"><div>N0</div></li><li id="ch8.lt45" class="half_rhythm"><div>M0</div></li></ul>
|
|
A priori subgroups according to (specific definitions depending on the available evidence):
|
|
<ul id="ch8.l21"><li id="ch8.lt46" class="half_rhythm"><div>sessile versus pedunculated tumour/polyp</div></li><li id="ch8.lt47" class="half_rhythm"><div>single versus fragmented specimen</div></li><li id="ch8.lt48" class="half_rhythm"><div>low grade tumours (grade 1) versus high grade (grade 2 or 3)</div></li><li id="ch8.lt49" class="half_rhythm"><div>lymphovascular infiltration</div></li><li id="ch8.lt50" class="half_rhythm"><div>positive versus negative resection margin</div></li><li id="ch8.lt51" class="half_rhythm"><div>Haggitt or kikuchi level</div></li></ul></p>
|
|
</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – intervention(s)/exposure(s)/prognostic factor(s)</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Observation/deferral of surgery</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – comparator(s)/control or reference (gold) standard</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Further surgical resection</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes and prioritisation</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Critical outcomes:
|
|
<ul id="ch8.l22"><li id="ch8.lt52" class="half_rhythm"><div>Overall survival (MID: statistical significance)</div></li><li id="ch8.lt53" class="half_rhythm"><div>Local recurrence</div></li><li id="ch8.lt54" class="half_rhythm"><div>Disease-free survival</div></li></ul>
|
|
Important outcomes:
|
|
<ul id="ch8.l23"><li id="ch8.lt55" class="half_rhythm"><div>Quality of life (measured using validated scales)</div></li><li id="ch8.lt56" class="half_rhythm"><div>Distant metastasis</div></li><li id="ch8.lt57" class="half_rhythm"><div>Treatment-related morbidity</div></li></ul>
|
|
Quality of Life MIDs from the literature:
|
|
<ul id="ch8.l24"><li id="ch8.lt58" class="half_rhythm"><div>EORTC QLQ-C30: 5 points</div></li><li id="ch8.lt59" class="half_rhythm"><div>EORTC QLQ-CR29: 5 points</div></li><li id="ch8.lt60" class="half_rhythm"><div>EORTC QLQ-CR38: 5 points</div></li><li id="ch8.lt61" class="half_rhythm"><div>EQ-5D: 0.09 using FACT-G quintiles</div></li><li id="ch8.lt62" class="half_rhythm"><div>FACT-C: 5 points</div></li><li id="ch8.lt63" class="half_rhythm"><div>FACT-G: 5 points</div></li><li id="ch8.lt64" class="half_rhythm"><div>SF-12: > 3.77 for the mental component summary (MCS) and > 3.29 for the physical component summary (PCS) of the Short Form SF-12 (SF-12)</div></li><li id="ch8.lt65" class="half_rhythm"><div>SF-36: > 7.1 for the physical functioning scale, > 4.9 for the bodily pain scale, and > 7.2 for the physical component summary</div></li></ul></td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – study design</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch8.l25"><li id="ch8.lt66" class="half_rhythm"><div>Systematic reviews of RCTs</div></li><li id="ch8.lt67" class="half_rhythm"><div>RCTs</div></li><li id="ch8.lt68" class="half_rhythm"><div>Prospective and retrospective comparative observational studies</div></li></ul>
|
|
</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other inclusion exclusion criteria</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inclusion:
|
|
<ul id="ch8.l26"><li id="ch8.lt69" class="half_rhythm"><div>English-language</div></li><li id="ch8.lt70" class="half_rhythm"><div>All settings will be considered that consider medications and treatments available in the UK</div></li><li id="ch8.lt71" class="half_rhythm"><div>Studies published post 2005</div></li><li id="ch8.lt72" class="half_rhythm"><div>Observational studies should include multivariate analysis controlling for the following confounding factors:
|
|
<ul id="ch8.l27" class="circle"><li id="ch8.lt73" class="half_rhythm"><div>Age</div></li><li id="ch8.lt74" class="half_rhythm"><div>Sex</div></li><li id="ch8.lt75" class="half_rhythm"><div>Race</div></li><li id="ch8.lt76" class="half_rhythm"><div>Functional status</div></li></ul></div></li></ul>
|
|
Studies conducted post 2005 will be considered for this review question because the guideline committee considered that treatment techniques have evolved and evidence prior to 2005 would not be relevant any longer.</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Proposed sensitivity/sub-group analysis, or meta-regression</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">In case of heterogeneity, the following subgroup analyses will be conducted:
|
|
<ul id="ch8.l28"><li id="ch8.lt77" class="half_rhythm"><div>sessile versus pedunculated tumour/polyp</div></li><li id="ch8.lt78" class="half_rhythm"><div>single versus fragmented specimen</div></li><li id="ch8.lt79" class="half_rhythm"><div>tumour grade</div></li><li id="ch8.lt80" class="half_rhythm"><div>lymphovascular infiltration</div></li><li id="ch8.lt81" class="half_rhythm"><div>positive vs negative resection margin</div></li><li id="ch8.lt82" class="half_rhythm"><div>Haggitt or kikuchi level</div></li></ul></td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Selection process – duplicate screening/selection/analysis</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Sifting, data extraction, appraisal of methodological quality and GRADE assessment will be performed by the systematic reviewer. Resolution of any disputes will be with the senior systematic reviewer and the Topic Advisor.</p>
|
|
<p>Quality control will be performed by the senior systematic reviewer.</p>
|
|
<p>Dual sifting will be undertaken for this question for a random 10% sample of the titles and abstracts identified by the search.</p>
|
|
</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data management (software)</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Pairwise meta-analyses will be performed using Cochrane Review Manager (RevMan5).</p>
|
|
<p>‘GRADEpro’ will be used to assess the quality of evidence for each outcome.</p>
|
|
<p>NGA STAR software will be used for study sifting, data extraction, recording quality assessment using checklists and generating bibliographies/citations.</p>
|
|
</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Information sources – databases and dates</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Potential sources to be searched: Medline, Medline In-Process, CCTR, CDSR, DARE, HTA, Embase</p>
|
|
<p>Limits (e.g. date, study design):</p>
|
|
<p>Apply standard animal/non-English language exclusion</p>
|
|
<p>Limit to RCTs and systematic reviews in first instance, but download all results</p>
|
|
<p>Dates: from 1995</p>
|
|
</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Identify if an update</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not an update</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Author contacts</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>
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<a href="https://www.nice.org.uk/guidance/indevelopment/gid-ng10060" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.nice.org<wbr style="display:inline-block"></wbr>​.uk/guidance/indevelopment/gid-ng10060</a>
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</p>
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<p>Developer: NGA</p>
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</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Highlight if amendment to previous protocol</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 4.5 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy – for one database</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see <a href="#ch8.appb">appendix B</a>.</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data collection process – forms/duplicate</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A standardised evidence table format will be used, and published as <a href="#ch8.appd">appendix D</a> (clinical evidence tables) or <a href="#ch8.apph">H</a> (economic evidence tables).</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data items – define all variables to be collected</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see evidence tables in <a href="#ch8.appd">appendix D</a> (clinical evidence tables) or <a href="#ch8.apph">H</a> (economic evidence tables).</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for assessing bias at outcome/study level</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Standard study checklists were used to critically appraise individual studies. For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></p>
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<p>
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<b>Appraisal of methodological quality:</b>
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</p>
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<p>The methodological quality of each study will be assessed using an appropriate checklist:
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<ul id="ch8.l29"><li id="ch8.lt83" class="half_rhythm"><div>ROBIS for systematic reviews</div></li><li id="ch8.lt84" class="half_rhythm"><div>Cochrane risk of bias tool for RCTs</div></li><li id="ch8.lt85" class="half_rhythm"><div>ROBINS-I for non-randomised studies</div></li></ul>
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The quality of the evidence for an outcome (i.e. across studies) will be assessed using GRADE.</p>
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<p>The risk of bias across all available evidence was evaluated for each outcome using an adaptation of the ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) toolbox’ developed by the international GRADE working group <a href="http://www.gradeworkinggroup.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.gradeworkinggroup.org/</a></p>
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</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Criteria for quantitative synthesis (where suitable)</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.4 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for analysis – combining studies and exploring (in)consistency</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Synthesis of data:
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<ul id="ch8.l30"><li id="ch8.lt86" class="half_rhythm"><div>Pairwise meta-analysis of randomised trials will be conducted where appropriate.</div></li><li id="ch8.lt87" class="half_rhythm"><div>When meta-analysing continuous data, final and change scores will be pooled if baselines are comparable. If any studies report both, the method used in the majority of studies will be analysed.</div></li></ul>
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Minimally important differences:</p>
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<p>The guideline committee identified statistically significant differences as appropriate indicators for clinical significance for all outcomes except quality of life for which published MIDs from literature will be used (see outcomes section for more information).</p>
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</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-bias assessment – publication bias, selective reporting bias</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></p>
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<p>If sufficient relevant RCT evidence is available, publication bias will be explored using RevMan software to examine funnel plots.</p>
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</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Assessment of confidence in cumulative evidence</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see sections 6.4 and 9.1 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rationale/context – Current management</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the introduction to the evidence review.</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Describe contributions of authors and guarantor</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A multidisciplinary committee developed the guideline. The committee was convened by The National Guideline Alliance and chaired by Peter Hoskin in line with section 3 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>. Staff from The National Guideline Alliance undertook systematic literature searches, appraised the evidence, conducted meta-analysis and cost-effectiveness analysis where appropriate, and drafted the guideline in collaboration with the committee. For details please see Supplement 1: methods.</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sources of funding/support</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The NGA is funded by NICE and hosted by the Royal College of Obstetricians and Gynaecologists</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Name of sponsor</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The NGA is funded by NICE and hosted by the Royal College of Obstetricians and Gynaecologists</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Roles of sponsor</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE funds the NGA to develop guidelines for those working in the NHS, public health, and social care in England</td></tr><tr><td headers="hd_h_ch8.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PROSPERO registration number</td><td headers="hd_h_ch8.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not registered</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">ASA: American Society of Anesthesiologists; CCTR: Cochrane Central Register of Controlled Trials; CDSR: Cochrane Database of Systematic Reviews; DARE: Database of Abstracts of Reviews of Effects; EQ-5D: EuroQol five dimensions questionnaire; EORTC QLQ-C30: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 Items; EORTC QLQ-CR29: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire colorectal cancer module (29 items); EORTC QLQ-CR38: European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire colorectal cancer module (38 items); FACT-C: Functional Assessment of Cancer Therapy questionnaire (colorectal cancer); FACT-G: Functional Assessment of Cancer Therapy questionnaire (general); GRADE: Grading of Recommendations Assessment, Development and Evaluation; HTA: Health Technology Assessment; M0: distant metastasis stage; MCS: mental component summary; MID: minimally important difference; NGA: National Guideline Alliance; NICE: National Institute for Health and Care Excellence; PCS: physical component summary; RCT: randomised controlled trial; RevMan5: Review Manager version 5; ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions; ROBIS: a tool for assessing risk of bias in systematic reviews; SF-12: 12-Item Short Form Survey; SF-36: 36-Item Short Form Survey</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch8appbtab1"><div id="ch8.appb.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK559940/table/ch8.appb.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch8.appb.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#</th><th id="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search</th></tr></thead><tbody><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp colorectal neoplasms/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp colorectal cancer/ or exp colon tumor/) use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((colorect* or colo rect* or colon or colonic) adj3 (adenocarcinoma* or cancer* or carcinoma* or malignan* or neoplas* or oncolog* or tumo?r*)).tw.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1-3</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">colonic polyps/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp colon polyp/ or colorectal polyp/) use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((colorect* or colo rect* or colon or colonic) adj2 (adenocarcinoma or polyp or polyps or polypoid)).tw.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(t1 or n0 or M0 or (early adj2 (adenocarcinoma* or cancer* or carcinoma* or malignan* or neoplas* or oncolog* or tumo?r*))).tw.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/5-8</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">endoscopic mucosal resection/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(endoscopic surgery/ or endoscopic mucosal resection/ or endoscopic polypectomy/ or polypectomy/) use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(endoscopic adj3 (excision or management or polypectom* or resect* or therap*)).tw.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(colonoscopic adj2 polypectom*).tw.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/10-13</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4 and 9 and 14</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Letter/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Editorial/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">News/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Historical Article/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comment/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Case Report/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/16-27</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">random*.ti,ab.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/29-31</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28 not 32</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animals, Laboratory/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experimentation/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Models, Animal/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/ use ppez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/ use emez</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/33-45</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 not 46</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 47 to (yr=“2005 - current” and english language)</td></tr><tr><td headers="hd_h_ch8.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49</td><td headers="hd_h_ch8.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">remove duplicates from 48</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch8appbtab2"><div id="ch8.appb.tab2" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK559940/table/ch8.appb.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch8.appb.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#</th><th id="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search</th></tr></thead><tbody><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Colorectal Neoplasms] explode all trees</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((colorect* or colo rect* or colon or colonic) near/3 (adenocarcinoma* or cancer* or carcinoma* or malignan* or neoplas* or oncolog* or tumo?r*))):ti,ab,kw</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1 or #2</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Colonic Polyps] this term only</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((colorect* or colo rect* or colon or colonic) near/2 (adenocarcinoma* or polyp or polyps or polypoid)):ti,ab,kw</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(t1 or n0 or M0 or (early near/2 (adenocarcinoma* or cancer* or carcinoma* or malignan* or neoplas* or oncolog* or tumo?r*))):ti,ab,kw</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">{or #4-#6}</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Endoscopic Mucosal Resection] this term only</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(endoscopic near/3 (excision or management or polypectom* or resect* or therap*)):ti,ab,kw</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(colonoscopic near/2 polypectom*):ti,ab,kw</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">{or #8-#10}</td></tr><tr><td headers="hd_h_ch8.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12</td><td headers="hd_h_ch8.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#3 and #7 and #11 with Cochrane Library publication date Between Jan 2005 and Dec 2018</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch8appcfig1"><div id="ch8.appc.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20Study%20selection%20flow%20chart.&p=BOOKS&id=559940_ch8appcf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK559940/bin/ch8appcf1.jpg" alt="Figure 1. Study selection flow chart." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">Study selection flow chart</span></h3></div></article><article data-type="fig" id="figobch8appefig1"><div id="ch8.appe.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%202.%20Comparison%201%3A%20endoscopic%20resection%20only%20versus%20endoscopic%20resection%20%2B%20surgery%20-%20overall%20survival.&p=BOOKS&id=559940_ch8appef1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK559940/bin/ch8appef1.jpg" alt="Figure 2. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - overall survival." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 2</span><span class="title">Comparison 1: endoscopic resection only versus endoscopic resection + surgery - overall survival</span></h3><div class="caption"><p>CI: confidence interval; O-E: observed minus expected; V: variance</p></div></div></article><article data-type="fig" id="figobch8appefig2"><div id="ch8.appe.fig2" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%203.%20Comparison%201%3A%20endoscopic%20resection%20only%20versus%20endoscopic%20resection%20%2B%20surgery%20-%20local%20recurrence%20in%20all%20patients%20and%20in%20low%20risk%20patients.&p=BOOKS&id=559940_ch8appef2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK559940/bin/ch8appef2.jpg" alt="Figure 3. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - local recurrence in all patients and in low risk patients." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 3</span><span class="title">Comparison 1: endoscopic resection only versus endoscopic resection + surgery - local recurrence in all patients and in low risk patients</span></h3><div class="caption"><p>CI: confidence interval; M-H: Mantel-Haenszel</p></div></div></article><article data-type="fig" id="figobch8appefig3"><div id="ch8.appe.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%204.%20Comparison%201%3A%20endoscopic%20resection%20only%20versus%20endoscopic%20resection%20%2B%20surgery%2C%20outcome%20-%20local%20recurrence%20in%20high%20risk%20patients.&p=BOOKS&id=559940_ch8appef3.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK559940/bin/ch8appef3.jpg" alt="Figure 4. Comparison 1: endoscopic resection only versus endoscopic resection + surgery, outcome - local recurrence in high risk patients." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 4</span><span class="title">Comparison 1: endoscopic resection only versus endoscopic resection + surgery, outcome - local recurrence in high risk patients</span></h3><div class="caption"><p>CI: confidence interval; ER: endoscopic resection; M-H: Mantel-Haenszel</p></div></div></article><article data-type="fig" id="figobch8appefig4"><div id="ch8.appe.fig4" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%205.%20Comparison%201%3A%20endoscopic%20resection%20only%20versus%20endoscopic%20resection%20%2B%20surgery%20-%20disease%20free%20survival.&p=BOOKS&id=559940_ch8appef4.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK559940/bin/ch8appef4.jpg" alt="Figure 5. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - disease free survival." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 5</span><span class="title">Comparison 1: endoscopic resection only versus endoscopic resection + surgery - disease free survival</span></h3><div class="caption"><p>CI: confidence interval; ER: endoscopic resection; O-E: observed minus expected; V: variance</p></div></div></article><article data-type="fig" id="figobch8appefig5"><div id="ch8.appe.fig5" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%206.%20Comparison%201%3A%20endoscopic%20resection%20only%20versus%20endoscopic%20resection%20%2B%20surgery%20-%20distant%20metastasis.&p=BOOKS&id=559940_ch8appef5.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK559940/bin/ch8appef5.jpg" alt="Figure 6. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - distant metastasis." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 6</span><span class="title">Comparison 1: endoscopic resection only versus endoscopic resection + surgery - distant metastasis</span></h3><div class="caption"><p>CI: confidence interval; M-H: Mantel-Haenszel</p></div></div></article><article data-type="fig" id="figobch8appefig6"><div id="ch8.appe.fig6" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%207.%20Comparison%201%3A%20endoscopic%20resection%20only%20versus%20endoscopic%20resection%20%2B%20surgery%20-%20treatment-related%20morbidity.&p=BOOKS&id=559940_ch8appef6.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK559940/bin/ch8appef6.jpg" alt="Figure 7. Comparison 1: endoscopic resection only versus endoscopic resection + surgery - treatment-related morbidity." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 7</span><span class="title">Comparison 1: endoscopic resection only versus endoscopic resection + surgery - treatment-related morbidity</span></h3><div class="caption"><p>CI: confidence interval; M-H: Mantel-Haenszel</p></div></div></article><article data-type="table-wrap" id="figobch8appftab1"><div id="ch8.appf.tab1" class="table"><h3><span class="label">Table 5</span><span class="title">Clinical evidence profile for comparison 1: endoscopic resection alone versus endoscopic resection + surgery</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK559940/table/ch8.appf.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch8.appf.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch8.appf.tab1_1_1_1_1" colspan="7" rowspan="1" style="text-align:left;vertical-align:bottom;">Quality assessment</th><th id="hd_h_ch8.appf.tab1_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">No of patients</th><th id="hd_h_ch8.appf.tab1_1_1_1_3" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Effect</th><th id="hd_h_ch8.appf.tab1_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch8.appf.tab1_1_1_1_4" style="text-align:left;vertical-align:bottom;">Quality</th><th id="hd_h_ch8.appf.tab1_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch8.appf.tab1_1_1_1_5" style="text-align:left;vertical-align:bottom;">Importance</th></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1" id="hd_h_ch8.appf.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No of studies</th><th headers="hd_h_ch8.appf.tab1_1_1_1_1" id="hd_h_ch8.appf.tab1_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Design</th><th headers="hd_h_ch8.appf.tab1_1_1_1_1" id="hd_h_ch8.appf.tab1_1_1_2_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk of bias</th><th headers="hd_h_ch8.appf.tab1_1_1_1_1" id="hd_h_ch8.appf.tab1_1_1_2_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency</th><th headers="hd_h_ch8.appf.tab1_1_1_1_1" id="hd_h_ch8.appf.tab1_1_1_2_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Indirectness</th><th headers="hd_h_ch8.appf.tab1_1_1_1_1" id="hd_h_ch8.appf.tab1_1_1_2_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Imprecision</th><th headers="hd_h_ch8.appf.tab1_1_1_1_1" id="hd_h_ch8.appf.tab1_1_1_2_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other considerations</th><th headers="hd_h_ch8.appf.tab1_1_1_1_2" id="hd_h_ch8.appf.tab1_1_1_2_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ER alone</th><th headers="hd_h_ch8.appf.tab1_1_1_1_2" id="hd_h_ch8.appf.tab1_1_1_2_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ER + surgery</th><th headers="hd_h_ch8.appf.tab1_1_1_1_3" id="hd_h_ch8.appf.tab1_1_1_2_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relative (95% CI)</th><th headers="hd_h_ch8.appf.tab1_1_1_1_3" id="hd_h_ch8.appf.tab1_1_1_2_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Overall survival</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>60/152</p>
|
|
<p>(39.5%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>52/152</p>
|
|
<p>(34.2%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HR 1.20 (0.82 to 1.73)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42 more per 1,000 (from 43 fewer to 131 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Local recurrence – all patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>7</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>16/551</p>
|
|
<p>(2.9%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>3/848</p>
|
|
<p>(0.4%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RD 0.03 (−0.05 to 0.10)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30 more per 1,000 (from 50 fewer to 100 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Local recurrence – low risk patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2/60</p>
|
|
<p>(3.3%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/104</p>
|
|
<p>(0.0%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RD 0.03 (−0.02 to 0.08)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30 more per 1,000 (from 20 fewer to 80 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Local recurrence – high risk patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>8</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>13/128</p>
|
|
<p>(10.2 %)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7/258 (2.7%)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 3.42 (0.75 to 15.66)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66 more per 1,000 (from 7 fewer to 398 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Disease free survival – all patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>4</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>69/450</p>
|
|
<p>(15.3%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>60/784</p>
|
|
<p>(7.7%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HR 1.32 (0.93 to 1.86)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22 more per 1,000 (from 5 fewer to 57 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Disease free survival – low risk patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>1/60</p>
|
|
<p>(1.7%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1/104 (1.0%)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HR 1.51 (0.08 to 28.02)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 more per 1,000 (from 9 fewer to 199 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Disease free survival – high risk patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>3/36</p>
|
|
<p>(8.3%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3/76 (3.9%)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HR 5.51 (0.42 to 72.27)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">145 more per 1,000 (from 23 fewer to 709 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Quality of life</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No evidence available</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Distant metastasis – all patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>4</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>9/551</p>
|
|
<p>(1.6%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>11/848</p>
|
|
<p>(1.3%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.93 (0.39 to 2.19)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 fewer per 1,000 (from 8 fewer to 15 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Distant metastasis – low risk patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>1/60</p>
|
|
<p>(1.7%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2/104 (1.9%)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.87 (0.08 to 9.36)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 fewer per 1,000 (from 18 fewer to 161 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Distant metastasis – high risk patients</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>3</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>9/128</p>
|
|
<p>(7.0%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9/258 (3.8%)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 2.03 (0.83 to 4.97)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36 more per 1,000 (from 6 fewer to 138 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Morbidity – interoperative surgical complications</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>4</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/152</p>
|
|
<p>(0.0%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6/152 (3.9%)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk difference −0.04 (−0.07 to −0.01)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40 more per 1,000 with surgery (from 10 more to 70 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_25_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Morbidity – postoperative surgical complications</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>4</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">not serious</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/152</p>
|
|
<p>(0.0%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>30/152</p>
|
|
<p>(19.7%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk difference −0.20 (−0.26 to −0.13</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">200 more per 1,000 with surgery (from 130 more to 260 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_27_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Morbidity – postoperative medical complications</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>4</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/152</p>
|
|
<p>(0.0%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>15/152</p>
|
|
<p>(9.9%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk difference −0.10 (−0.15 to −0.05)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">100 more per 1,000 with surgery (from 50 more to 150 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_h_ch8.appf.tab1_1_1_2_3 hd_h_ch8.appf.tab1_1_1_2_4 hd_h_ch8.appf.tab1_1_1_2_5 hd_h_ch8.appf.tab1_1_1_2_6 hd_h_ch8.appf.tab1_1_1_2_7 hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_h_ch8.appf.tab1_1_1_2_9 hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_h_ch8.appf.tab1_1_1_2_11 hd_h_ch8.appf.tab1_1_1_1_4 hd_h_ch8.appf.tab1_1_1_1_5" id="hd_b_ch8.appf.tab1_1_1_29_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:top;">Morbidity – grade 3 or 4 complications</th></tr><tr><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_1 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_2 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_3 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>4</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_4 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_5 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>1</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_6 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>2</sup></td><td headers="hd_h_ch8.appf.tab1_1_1_1_1 hd_h_ch8.appf.tab1_1_1_2_7 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_8 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0/152</p>
|
|
<p>(0.0%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_2 hd_h_ch8.appf.tab1_1_1_2_9 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>20/152</p>
|
|
<p>(13.2%)</p>
|
|
</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_10 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk difference −0.13 (−0.19 to −0.08)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_3 hd_h_ch8.appf.tab1_1_1_2_11 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">130 more per 1,000 with surgery (from 80 more to 190 more)</td><td headers="hd_h_ch8.appf.tab1_1_1_1_4 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VERY LOW</td><td headers="hd_h_ch8.appf.tab1_1_1_1_5 hd_b_ch8.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">CI: confidence interval; ER: endoscopic resection; HR: hazard ratio; OR: odds ratio; RR: relative risk</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch8.appf.tab1_1"><p class="no_margin">Quality of evidence downgraded by 1 because patients with rectal cancer were included.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch8.appf.tab1_2"><p class="no_margin">Quality of evidence downgraded by 1 because of imprecision of the effect estimate (< 300 events for dichotomous outcomes or < 400 participants for continuous outcomes).</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch8.appf.tab1_3"><p class="no_margin">Quality of evidence downgraded by 1 because of potential bias due to confounding not controlled for in Kouyama and Levic and due to post-treatment deviations from intended interventions (Levic).</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch8.appf.tab1_4"><p class="no_margin">Quality of evidence downgraded by 2 because patients with rectal cancer were included and the comparison group included patients who had surgery rather than ER as their initial treatment.</p></div></dd></dl><dl class="bkr_refwrap"><dt>5</dt><dd><div id="ch8.appf.tab1_5"><p class="no_margin">Quality of evidence downgraded by 1 because of potential bias due to confounding not controlled for in Tamaru.</p></div></dd></dl><dl class="bkr_refwrap"><dt>6</dt><dd><div id="ch8.appf.tab1_6"><p class="no_margin">Quality of evidence downgraded by 2 because of potential for bias due to confounding not controlled for and post-treatment deviations from intended interventions (Levic)</p></div></dd></dl><dl class="bkr_refwrap"><dt>7</dt><dd><div id="ch8.appf.tab1_7"><p class="no_margin">Quality of evidence downgraded by 1 - 1 study shows no difference but the other 2 show significant benefit with surgery</p></div></dd></dl><dl class="bkr_refwrap"><dt>8</dt><dd><div id="ch8.appf.tab1_8"><p class="no_margin">Quality of evidence downgraded by 1 due to considerable heterogeneity not explained by subgroup analysis.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch8appktab1"><div id="ch8.appk.tab1" class="table"><h3><span class="label">Table 6</span><span class="title">Excluded studies and reasons for their exclusion</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK559940/table/ch8.appk.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch8.appk.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study</th><th id="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reason for exclusion</th></tr></thead><tbody><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Andreoni
|
|
B, Camellini
|
|
L, Sonzogni
|
|
A, et al. (2011) Multicentric GISCoR Study “intensive clinical follow-up versus surgical radicalization after complete endoscopic polypectomy of a malignant adenoma” (SEC-GISCoR). Updates in Surgery
|
|
63: 171–177 [<a href="https://pubmed.ncbi.nlm.nih.gov/21647795" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21647795</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0% event rates.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Asayama
|
|
N, Oka
|
|
S, Tanaka
|
|
S, et al. (2016) Long-term outcomes after treatment for pedunculated-type T1 colorectal carcinoma: a multicenter retrospective cohort study. Journal of Gastroenterology
|
|
51: 702–710 [<a href="https://pubmed.ncbi.nlm.nih.gov/26573300" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26573300</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Poor quality reporting/uncertainty regarding data that are reported.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Asayama, N, Oka, S, Tanaka
|
|
S, et al. (2016) Long-term outcomes after treatment for T1 colorectal carcinoma. International Journal of Colorectal Disease
|
|
31: 571–578 [<a href="https://pubmed.ncbi.nlm.nih.gov/26689400" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26689400</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data reported in Tamaru paper.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Backes
|
|
Y, De Vos
|
|
T, Van Bergeijk
|
|
J, et al. (2017) Risk for Incomplete Resection after Macroscopic Radical Endoscopic Resection of T1 Colorectal Cancer: A Multicenter Cohort Study. American Journal of Gastroenterology
|
|
112: 785–796 [<a href="https://pubmed.ncbi.nlm.nih.gov/28323275" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28323275</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not report multivariate analyses.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Belderbos
|
|
T, van Erning
|
|
F, de Hingh
|
|
I, et al. (2017) Long-term Recurrence-free Survival After Standard Endoscopic Resection Versus Surgical Resection of Submucosal Invasive Colorectal Cancer: A Population-based Study. Clinical Gastroenterology and Hepatology
|
|
15: 403–411.e1 [<a href="https://pubmed.ncbi.nlm.nih.gov/27609703" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27609703</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not report multivariate analyses.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Benizri
|
|
E, Bereder
|
|
J, Rahili
|
|
A, et al. (2012) Additional colectomy after colonoscopic polypectomy for T1 colon cancer: A fine balance between oncologic benefit and operative risk, International Journal of Colorectal Disease, 27, 1473–1478 [<a href="https://pubmed.ncbi.nlm.nih.gov/22454048" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22454048</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">All patients underwent colectomy.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Borschitz
|
|
T, Heintz
|
|
A, Junginger
|
|
T (2006) The influence of histopathologic criteria on the long-term prognosis of locally excised pT1 rectal carcinomas: Results of local excision (transanal endoscopic microsurgery) and immediate reoperation, Diseases of the Colon and Rectum, 49, 1492–1500. [<a href="https://pubmed.ncbi.nlm.nih.gov/16897336" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16897336</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not report multivariate analyses.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Buchner
|
|
A, Guarner-Argente
|
|
C, Ginsberg
|
|
G (2012) Outcomes of EMR of defiant colorectal lesions directed to an endoscopy referral center, Gastrointestinal Endoscopy, 76, 255–63 [<a href="https://pubmed.ncbi.nlm.nih.gov/22657404" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22657404</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare post endoscopic resection treatment (deferral of surgery vs surgery) in a sample who have all had endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Chen
|
|
T, Zhang
|
|
Y, Chen
|
|
W, et al. (2017) Efficacy and safety of additional surgery after non-curative endoscopic submucosal dissection for early colorectal cancer, BMC Gastroenterology, 17, 134 [<a href="/pmc/articles/PMC5704364/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5704364</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29183272" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29183272</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not comparative</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Choi
|
|
J, Jung
|
|
S, Shim
|
|
K, et al. (2015) Meta-analysis of predictive clinicopathologic factors for lymph node metastasis in patients with early colorectal carcinoma, Journal of Korean medical science, 30, 398–406, 2015 [<a href="/pmc/articles/PMC4366960/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4366960</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25829807" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25829807</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Measures risk of lymph node metastasis rather than outcomes specified in our protocol</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Coleman
|
|
H, Loughrey
|
|
M, Murray
|
|
L, et al. (2015) Colorectal cancer risk following adenoma removal: A large prospective population-based cohort study, Cancer Epidemiology Biomarkers and Prevention, 24, 1373–1380, 2015 [<a href="/pmc/articles/PMC4560642/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4560642</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26082403" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26082403</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare post endoscopic resection treatment (deferral of surgery vs surgery) in a sample who have all had endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Cooper
|
|
G, Xu
|
|
F, Barnholtz
|
|
S, et al. (2012) Management of malignant colonic polyps: a population-based analysis of colonoscopic polypectomy versus surgery, Cancer, 118, 651–9 [<a href="/pmc/articles/PMC3193545/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3193545</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21751204" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21751204</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The study compares surgical resection to colonoscopic polypectomy. Not all patients were treated with endoscopic resection to begin with.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Desgrippes
|
|
R, Beauchamp
|
|
C, Henno
|
|
S, et al. (2013) Prevalence and predictive factors of the need for surgery for advanced colorectal adenoma, Colorectal Disease, 15, 683–688 [<a href="https://pubmed.ncbi.nlm.nih.gov/23398651" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23398651</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare post endoscopic resection treatment (deferral of surgery vs surgery) in a sample who have all had endoscopic resection. Measures predictive factors for surgery in a sample in which some of the patients have had endocsopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Gill
|
|
M, Rutter
|
|
M, Holtham
|
|
S (2013) Management and short-term outcome of malignant colorectal polyps in the north of England. Colorectal Disease, 15, 169–176 [<a href="https://pubmed.ncbi.nlm.nih.gov/22709241" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22709241</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not report multivariate analysis.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Goncalves
|
|
B, Fontainhas
|
|
V, Caetano
|
|
A, et al. (2013) Oncological outcomes after endoscopic removal of malignant colorectal polyps. Revista Espanola de Enfermedades Digestivas, 105, 454–61 [<a href="https://pubmed.ncbi.nlm.nih.gov/24274442" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24274442</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not present multivariate analysis of outcomes of interest.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Hahnloser
|
|
D, Wolff
|
|
B, Larson
|
|
D, et al. (2005) Immediate radical resection after local excision of rectal cancer: an oncologic compromise?
|
|
Diseases of the Colon and Rectum, 48, 429–437 [<a href="https://pubmed.ncbi.nlm.nih.gov/15747069" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15747069</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">All patients had rectal cancer.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Hassan
|
|
C, Pickhardt
|
|
P, Di Giulio
|
|
E, et al. (2010) Value-of-information analysis to guide future research in the management of the colorectal malignant polyp, Diseases of the Colon and Rectum, 53, 135–142 [<a href="https://pubmed.ncbi.nlm.nih.gov/20087087" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20087087</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not report on outcomes specified in protocol.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Hassan
|
|
C, Repici
|
|
A, Sharma
|
|
P, et al. (2016) Efficacy and safety of endoscopic resection of large colorectal polyps: A systematic review and meta-analysis, Gut, 65, 806–820 [<a href="https://pubmed.ncbi.nlm.nih.gov/25681402" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25681402</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparisons do not match those specified in protocol.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Issa
|
|
N, Fenig
|
|
Y, Khatib
|
|
M, et al. (2017) Transanal Endoscopic Microsurgery Combined with Laparoscopic Colectomy for Synchronous Colorectal Tumors: A Word of Caution. Journal of Laparoendoscopic and Advanced Surgical Techniques
|
|
27, 605–610 [<a href="https://pubmed.ncbi.nlm.nih.gov/27992283" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27992283</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study evaluates transanal endoscopic microsurgery laparoscopic colectomy. Does not compare post endoscopic resection treatment (deferral of surgery vs surgery) in a sample who have all had endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Kidane
|
|
B, Chadi
|
|
S, Kanters
|
|
S, et al. (2015) Local resection compared with radical resection in the treatment of T1N0M0 rectal adenocarcinoma: A systematic review and meta-analysis, Diseases of the Colon and Rectum, 58, 122–140 [<a href="https://pubmed.ncbi.nlm.nih.gov/25489704" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25489704</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparisons not relevant to protocol.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Kobayashi
|
|
H, Higuchi
|
|
T, Uetake
|
|
H, et al. (2012) Resection with en bloc removal of regional lymph node after endoscopic resection for T1 colorectal cancer, Annals of Surgical Oncology, 19, 4161–4167 [<a href="https://pubmed.ncbi.nlm.nih.gov/22772868" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22772868</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparison does not include deferral of surgery.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Kogler
|
|
P, Kafka-Ritsch
|
|
R, Ofner
|
|
D, et al. (2013) Is limited surgery justified in the treatment of T1 colorectal cancer?
|
|
Surgical Endoscopy and Other Interventional Techniques. 27: 817–825 [<a href="https://pubmed.ncbi.nlm.nih.gov/23232987" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23232987</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Descriptive. Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Kozak
|
|
V, Kalady
|
|
M, Gamaleldin
|
|
M, et al. (2017) Colorectal surveillance after segmental resection for young-onset colorectal cancer: is there evidence for extended resection?
|
|
Colorectal Disease, 19, O386–O392 [<a href="https://pubmed.ncbi.nlm.nih.gov/28865167" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28865167</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Lebedyev
|
|
A, Tulchinsky
|
|
H, Rabau
|
|
M, et al. (2009) Long-term results of local excision for T1 rectal carcinoma: The experience of two colorectal units. Techniques in Coloproctology
|
|
13
|
|
231–236 [<a href="https://pubmed.ncbi.nlm.nih.gov/19644648" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19644648</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Lee
|
|
T, Rees
|
|
C, Nickerson
|
|
C, et al. (2013) Management of complex colonic polyps in the English Bowel Cancer Screening Programme, British Journal of Surgery, 100, 1633–1639 [<a href="https://pubmed.ncbi.nlm.nih.gov/24264787" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24264787</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Levic
|
|
K, Kjaer
|
|
M, Bulut
|
|
O, et al. (2015) Watchful waiting versus colorectal resection after polypectomy for malignant colorectal polyps, Danish Medical Journal, 62, A4996 [<a href="https://pubmed.ncbi.nlm.nih.gov/25557332" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25557332</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not present multivariate analysis of outcomes of interest.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Lim
|
|
D, Robinson
|
|
R, Wurm
|
|
P, et al. (2017) Outcome of an endoscopic mucosal resection service for large sessile colonic polyps (>= 20 mm) over A 9-Year period: A single centre experience and analysis of change over time in a university teaching hospital. Journal of Gastroenterology and Hepatology Research, 6, 2318–2323
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Meining
|
|
A, von Delius
|
|
S, Eames
|
|
T
|
|
et al. (2011) Risk Factors for Unfavorable Outcomes After Endoscopic Removal of Submucosal Invasive Colorectal Tumors, Clinical Gastroenterology and Hepatology, 9, 590–594 [<a href="https://pubmed.ncbi.nlm.nih.gov/21320641" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21320641</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not present multivariate analysis of outcomes of interest.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Mitchell
|
|
R, Zhang
|
|
C, Galorport
|
|
C
|
|
et al. (2018) Characteristics of Patients with Colonic Polyps Requiring Segmental Resection, Canadian journal of gastroenterology & hepatology, 2018, 7046385 [<a href="/pmc/articles/PMC5833871/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5833871</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29670868" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29670868</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Nozawa
|
|
H, Ishihara
|
|
S, Fujishiro
|
|
M, et al. (2016) Outcome of salvage surgery for colorectal cancer initially treated by upfront endoscopic therapy, Surgery (United States), 159, 713–720 [<a href="https://pubmed.ncbi.nlm.nih.gov/26477474" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26477474</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not present multivariate analysis of outcomes of interest.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Overwater
|
|
A, Kessels
|
|
K, Elias
|
|
S, et al. (2018) Endoscopic resection of high-risk T1 colorectal carcinoma prior to surgical resection has no adverse effect on long-term outcomes. Gut
|
|
67: 284–290 [<a href="https://pubmed.ncbi.nlm.nih.gov/27811313" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27811313</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Primary surgery (only) vs surgery after endoscopic resection. Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Park
|
|
J, Cheon
|
|
J, Kwon
|
|
J, et al. (2011) Clinical outcomes and factors related to resectability and curability of EMR for early colorectal cancer. Gastrointestinal Endoscopy, 74
|
|
1337–1346 [<a href="https://pubmed.ncbi.nlm.nih.gov/22136778" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22136778</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Quaresima
|
|
S, Balla
|
|
A, D’Ambrosio
|
|
G, et al. (2016) Endoluminal loco-regional resection by TEM after R1 endoscopic removal or recurrence of rectal tumors, Minimally Invasive Therapy & Allied Technologies: Mitat, 25, 134–40 [<a href="https://pubmed.ncbi.nlm.nih.gov/26882538" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26882538</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Rickert
|
|
A, Aliyev
|
|
R, Belle
|
|
S, et al. (2014) Oncologic colorectal resection after endoscopic treatment of malignant polyps: Does endoscopy have an adverse effect on oncologic and surgical outcomes?, Gastrointestinal Endoscopy, 79, 951–960 [<a href="https://pubmed.ncbi.nlm.nih.gov/24412574" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24412574</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection. Impact of prior ER on outcomes after surgical resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Shin
|
|
J, Han
|
|
K, Hyun
|
|
J, et al. (2018) Risk of recurrence after endoscopic resection of early colorectal cancer with positive margins, Endoscopy, 50, 241–247 [<a href="https://pubmed.ncbi.nlm.nih.gov/29112994" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29112994</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not comparative.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Silva
|
|
G, de Moura
|
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E, Bernardo
|
|
W, et al. (2016) Endoscopic versus surgical resection for early colorectal cancer-a systematic review and meta-analysis, Journal of Gastrointestinal Oncology, 7, 326–335 [<a href="/pmc/articles/PMC4880782/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4880782</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27284463" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27284463</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparisons do not match those specified in protocol.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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Stipa
|
|
F, Giaccaglia
|
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V, Burza
|
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A (2012) Management and outcome of local recurrence following transanal endoscopic microsurgery for rectal cancer, Diseases of the Colon and Rectum, 55, 262–269 [<a href="https://pubmed.ncbi.nlm.nih.gov/22469792" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22469792</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not present multivariate analysis of outcomes of interest.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Su
|
|
M, Ho
|
|
Y, Hsu
|
|
C, et al. (2005) How can colorectal neoplasms be treated during colonoscopy?, World Journal of Gastroenterology, 11, 2806–2810 [<a href="/pmc/articles/PMC4305922/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4305922</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/15884128" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15884128</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Voloyiannis
|
|
T, Snyder
|
|
M, Bailey
|
|
R, et al. (2008) Management of the difficult colon polyp referred for resection: Resect or rescope?, Diseases of the Colon and Rectum, 51, 292–295 [<a href="https://pubmed.ncbi.nlm.nih.gov/18202891" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18202891</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Watanabe
|
|
D, Toyonaga
|
|
T, Ooi
|
|
M, et al. (2018) Clinical outcomes of deep invasive submucosal colorectal cancer after ESD, Surgical Endoscopy, 32, 2123–2130 [<a href="https://pubmed.ncbi.nlm.nih.gov/29098429" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29098429</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Wu
|
|
X, Liang
|
|
J, Church
|
|
J (2015) Management of sessile malignant polyps: is colonoscopic polypectomy enough?
|
|
Surgical Endoscopy, 29, 2947–52 [<a href="https://pubmed.ncbi.nlm.nih.gov/25537379" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25537379</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Descriptive.</td></tr><tr><td headers="hd_h_ch8.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
Yoshida
|
|
D, Kono
|
|
S, Moore
|
|
M
|
|
et al. (2007) Colorectal polypectomy and risk of colorectal cancer by subsite: The Fukuoka colorectal cancer study. Japanese Journal of Clinical Oncology, 37, 597–602 [<a href="https://pubmed.ncbi.nlm.nih.gov/17716994" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17716994</span></a>]
|
|
</td><td headers="hd_h_ch8.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does not compare deferral of surgery vs surgery in patients who have previously received endoscopic resection.</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">CRC: colorectal cancer; CT: chemotherapy; RCT: randomised control trial</p></div></dd></dl></dl></div></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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