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preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style"><div class="fm-sec bkr_bottom_sep"><div class="bkr_thumb"><a href="https://www.nice.org.uk" title="National Institute for Health and Care Excellence (NICE)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng142er1-lrg.png" alt="Cover of Evidence review: What are the best service models to support the identification of people who may be entering the last year of life?" /></a></div><div class="bkr_bib"><h1 id="_NBK558773_"><span itemprop="name">Evidence review: What are the best service models to support the identification of people who may be entering the last year of life?</span></h1><div class="subtitle">End of life care for adults: service delivery</div><p><b>Evidence review A</b></p><p><i>NICE Guideline, No. 142</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Guideline Centre (UK)</span>.</p><div class="half_rhythm">London: <a href="https://www.nice.org.uk" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2019 Oct</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-3560-4</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2019.</div></div><div class="bkr_clear"></div></div><div id="ch1.s1"><h2 id="_ch1_s1_">1. Identification of people who may be in their last year of life and their carers</h2><div id="ch1.s1.1"><h3>1.1. Review question: What are the best service models to support the identification of people who may be entering the last year of life?</h3></div><div id="ch1.s1.2"><h3>1.2. Introduction</h3><p>There are wide ranging benefits to be gained from identifying people who may be nearing the end of life. Following effective identification, time can then be given to allow patients, and those important to them, to re-align their priorities for care. This can facilitate the delivery of health and social care interventions that are targeted to ensure patients’ priorities are recognised and, where possible, met. Reducing the burden of treatments that may be unnecessary and minimising the risk of inappropriate hospital admission are potential benefits to be gained from effective identification of this cohort.<a class="bibr" href="#ch1.ref66" rid="ch1.ref66"><sup>66</sup></a></p><p>Prognostication for individual patients is a recognised challenge for healthcare professionals, due in part to the implications of the decisions being made and the inherent uncertainty in the outcomes for individual patients.<a class="bibr" href="#ch1.ref49" rid="ch1.ref49"><sup>49</sup></a> A variety of tools and approaches have been developed in an attempt to augment what could be seen as a ‘typical’ intuitive approach.<a class="bibr" href="#ch1.ref56" rid="ch1.ref56"><sup>56</sup></a> The accuracy of tools which attempt to identify dying patients was not part of the guideline scope. This review seeks to explore the evidence for service delivery models which can best support the identification of people who may be in their last year of life.</p></div><div id="ch1.s1.3"><h3>1.3. PICO table</h3><p>For full details see the review protocol in <a href="#ch1.appa">Appendix A</a>.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch1tab1"><a href="/books/NBK558773/table/ch1.tab1/?report=objectonly" target="object" title="Table 1" class="img_link icnblk_img figpopup" rid-figpopup="figch1tab1" rid-ob="figobch1tab1"><img class="small-thumb" src="/books/NBK558773/table/ch1.tab1/?report=thumb" src-large="/books/NBK558773/table/ch1.tab1/?report=previmg" alt="Table 1. PICO characteristics of review question." /></a><div class="icnblk_cntnt"><h4 id="ch1.tab1"><a href="/books/NBK558773/table/ch1.tab1/?report=objectonly" target="object" rid-ob="figobch1tab1">Table 1</a></h4><p class="float-caption no_bottom_margin">PICO characteristics of review question. </p></div></div></div><div id="ch1.s1.4"><h3>1.4. Clinical evidence</h3><div id="ch1.s1.4.1"><h4>1.4.1. Included studies</h4><p>A search was conducted for randomised or non-randomised comparative studies on service models to support the identification of people who may be entering the last year of life.</p><p>One clinical study (Campbell 2004)<a class="bibr" href="#ch1.ref13" rid="ch1.ref13"><sup>13</sup></a> was identified for this review.</p></div><div id="ch1.s1.4.2"><h4>1.4.2. Excluded studies</h4><p>See the excluded studies list in <a href="#ch1.appg">Appendix G</a>.</p></div><div id="ch1.s1.4.3"><h4>1.4.3. Summary of clinical studies included in the evidence review</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch1tab2"><a href="/books/NBK558773/table/ch1.tab2/?report=objectonly" target="object" title="Table 2" class="img_link icnblk_img figpopup" rid-figpopup="figch1tab2" rid-ob="figobch1tab2"><img class="small-thumb" src="/books/NBK558773/table/ch1.tab2/?report=thumb" src-large="/books/NBK558773/table/ch1.tab2/?report=previmg" alt="Table 2. Summary of studies included in the evidence review." /></a><div class="icnblk_cntnt"><h4 id="ch1.tab2"><a href="/books/NBK558773/table/ch1.tab2/?report=objectonly" target="object" rid-ob="figobch1tab2">Table 2</a></h4><p class="float-caption no_bottom_margin">Summary of studies included in the evidence review. </p></div></div><p>See <a href="#ch1.appd">Appendix D</a> for full evidence tables.</p></div><div id="ch1.s1.4.4"><h4>1.4.4. Quality assessment of clinical studies included in the evidence review</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch1tab3"><a href="/books/NBK558773/table/ch1.tab3/?report=objectonly" target="object" title="Table 3" class="img_link icnblk_img figpopup" rid-figpopup="figch1tab3" rid-ob="figobch1tab3"><img class="small-thumb" src="/books/NBK558773/table/ch1.tab3/?report=thumb" src-large="/books/NBK558773/table/ch1.tab3/?report=previmg" alt="Table 3. Clinical evidence summary: Proactive case-finding versus no intervention." /></a><div class="icnblk_cntnt"><h4 id="ch1.tab3"><a href="/books/NBK558773/table/ch1.tab3/?report=objectonly" target="object" rid-ob="figobch1tab3">Table 3</a></h4><p class="float-caption no_bottom_margin">Clinical evidence summary: Proactive case-finding versus no intervention. </p></div></div><p>See <a href="#ch1.appf">Appendix F</a> for full GRADE tables.</p></div></div><div id="ch1.s1.5"><h3>1.5. Economic evidence</h3><div id="ch1.s1.5.1"><h4>1.5.1. Included studies</h4><p>No relevant health economic studies were identified.</p></div><div id="ch1.s1.5.2"><h4>1.5.2. Excluded studies</h4><p>No health economic studies that were relevant to this question were excluded due to assessment of limited applicability or methodological limitations.</p><p>See also the health economic study selection flow chart in <a href="#ch1.appc">Appendix C</a>.</p></div></div><div id="ch1.s1.6"><h3>1.6. Resource costs</h3><p>Recommendations made based on this review (see section <b>Error! Reference source not found.</b>) are not expected to have a substantial impact on resources.</p></div><div id="ch1.s1.7"><h3>1.7. Evidence statements</h3><div id="ch1.s1.7.1"><h4>1.7.1. Clinical evidence statements</h4><div id="ch1.s1.7.1.1"><h5>Proactive case-finding versus no intervention</h5><p>One study compared the proactive case-finding to no intervention. There was a clinically important benefit for the proactive case-finding for length of stay in hospital and in MICU (n=52; very low quality), but a clinically important benefit for no intervention for discharge to another hospital (n=52; very low quality).</p></div></div><div id="ch1.s1.7.2"><h4>1.7.2. Health economic evidence statements</h4><ul id="ch1.l10"><li id="ch1.lt42" class="half_rhythm"><div>No relevant economic evaluations were identified.</div></li></ul></div></div><div id="ch1.s1.8"><h3>1.8. The Committee’s discussion of the evidence</h3><div id="ch1.s1.8.1"><h4>1.8.1. Interpreting the evidence</h4><div id="ch1.s1.8.1.1"><h5>1.8.1.1. The outcomes that matter most</h5><p>The committee identified quality of life, preferred place of care and death, and longevity of carer as the critical outcomes for identifying people who may be in their last year of life. The following outcomes were identified as important: length of stay, length of survival hospitalisation, number of hospital visits, number of visits to accident and emergency, number of unscheduled admissions, use of community services, avoidable or inappropriate admissions to ICU, inappropriate attempts at cardiopulmonary resuscitation, staff satisfaction, patient or carer reported outcomes and carer health.</p><p>No evidence was found for the following outcomes: quality of life, preferred place of care and death, length of survival and longevity of carer as the critical outcomes for identifying people in their who may be in the last year of life, number of hospital visits, number of visits to accident and emergency, number of unscheduled admissions, use of community services, avoidable or inappropriate admissions to ICU, inappropriate attempts at cardiopulmonary resuscitation, staff satisfaction, patient or carer reported outcomes and carer health.</p><p>See tables 7 and 8 in the <a href="/books/NBK558773/bin/bm1.pdf">Methods</a> chapter for a detailed explanation of why the committee selected these outcomes.</p></div><div id="ch1.s1.8.1.2"><h5>1.8.1.2. The quality of the evidence</h5><p>One non-randomised study comparing pro-active case-finding to no intervention was identified. There was no evidence found for proactive care, centralised records, gold standard framework, AMBER care bundle, electronic discharge notifications, video-conferencing, multi-disciplinary meetings, virtual hospital/ward rounds and established routines for handovers and exchange of information.. Evidence was available evaluating the accuracy of various tools but these studies did not compare different service delivery models.</p><p>The evidence was very low quality due to high risk of bias and imprecision. It was a non-randomised study with few participants. The Committee agreed that this study lacked direct relevance, as it was a different healthcare system and ICU outreach in UK already includes this type of intervention.</p></div><div id="ch1.s1.8.1.3"><h5>1.8.1.3. Benefits and harms</h5><p>Length of stay in hospital and length of stay in MICU were lower in the pro-active case-finding group. The number of people discharged to another hospital was higher, but this was based on only more individual. The outcome ‘discharged to another hospital ‘was included as a proxy for the outcome hospitalisation, the Committee clarified that this would be a benefit in this evidence as it was discharge to a community hospital.</p><p>The Committee agreed that although the study met the protocol the setting was not directly relevant to the NHS and the quality of the evidence was too low for them to be confident in basing a recommendation for proactive case finding. The Committee made a consensus based recommendation based on their clinical experience that early identification can support people in making decisions about their priorities for care.</p><p>The Committee recommended that all NHS commissioned services should have a system in place that would identify people who may be in their last year of life. The identification and documentation of people who may be in their last year of life is helpful to service planners for commissioning future services for people in the last year of life. Timely identification is required to ensure people’s needs are met at the end of life (for example, being cared for in the place they want to). The Committee agreed it was important that information should be shared between services. This would enable people to have access to appropriate well-coordinated care.</p></div></div><div id="ch1.s1.8.2"><h4>1.8.2. Cost effectiveness and resource use</h4><p>“The national primary care snapshot audit in End of Life Care 2010/11 of the provision of EoLC based on use of Palliative Care/GSF Registers in primary care for 502 GP practices in 15 PCTs and 7,200 case notes, over a two-month period found 27% of people who died were included on the palliative care register and of these 23% had a non-cancer diagnosis. Most significantly though it found that those people included on the palliative care register were more likely to receive well-co-ordinated care (for example handover to out-of-hours, anticipatory prescribing) and more likely to have been offered an advance care planning discussion and to die in their preferred place of choice.”<a class="bibr" href="#ch1.ref73" rid="ch1.ref73"><sup>73</sup></a></p><p>It is anticipated that 20% of deaths are unpredictable and people who die in these circumstances could not have been identified as approaching the end of life. However, it is clear that the majority of people dying from predictable causes are also not being appropriately identified as approaching the end of life. This can have significant consequences for patients. Unidentified people will not receive appropriate holistic needs assessments to determine what services and care they would benefit from, and this in turn will lead to their needs not being adequately met by the health and social care services.</p><p>Unidentified people would be likely to experience a lower quality of life than if they had been identified and offered access to services to support their needs. Poor identification can also have significant financial consequences for the NHS, as early identification of people who may be in the last year of life can reduce the costs of end of life service provision, for example by ensuing necessary services are in place to avoid costly emergency admissions to hospital.</p><p>Currently, the majority of carers who are caring for someone that is in the last year of life are not identified as being a carer by the health and/or social services, and therefore do not receive access to services to support them in their caring role. Identifying a carer should trigger a referral for a carer assessment for which they are legally entitled to. Identifying carers means they can be referred to carer support services, ensuring their own needs can be met and enabling them to be adequately equipped, skilled and informed, to care for someone outside of hospital. These support services could reduce avoidable hospital admissions and improve quality of life and health outcomes for both the carer and the person in the last year of life.</p><p>Increasing the number of people that are identified either as carers or those likely to be in the last year of life will have a mixed effect on costs to the NHS. Increased identification will increase the number of people who are offered access to carer support services, supportive care, palliative care or end of life care services therefore will increase the demand for these services. This will increase costs but is fundamental to good end of life care. However, some of the services could decrease the probability and frequency that people in the last year of life are admitted to hospital and could increase the chance and length of time that they can be cared for in their preferred place of choice which could in turn, decrease costs to the NHS.</p><p>No health economic studies were identified for inclusion in this review and the one clinical study that was included was not considered relevant to base recommendations on. The committee considered the costs to the NHS when formulating the consensus recommendations however, due to wide scale national variation and uncertainty in effect that increasing identification will have on costs (as highlighted above) they could not estimate how the recommendations they have made on identification will affect NHS costs. The cost implications of the recommendations will depend on the local processes currently in existence or that they decide to establish in order to adequately identify and record people thought to be in the last year of their life and, if applicable, their carers.</p></div><div id="ch1.s1.8.3"><h4>1.8.3. Other factors the committee took into account</h4><p>No evidence was identified to evaluate the effectiveness of systems that are currently used in practice to identify people who are likely to be in the last year of life, the Committee agreed it was important to note that there are systems in place but could not recommend any one system. They are aware of systems, for example the Gold Standards Framework, Amber Care Bundle, Supportive and Palliative Care Indicators Tool (SPICT).</p><p>The committee discussed and acknowledged the negative connotations the term register can have and the perceived stigma attached to being placed on a register. 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J. A qualitative analysis of the elements used by palliative care clinicians when formulating a survival estimate. BMJ Supportive & Palliative Care. 2013; 3(3):330–334 [<a href="/pmc/articles/PMC3756520/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3756520</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24644752" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24644752</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>21.</dt><dd><div class="bk_ref" id="ch1.ref21">Cotogni
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P, A
|
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DEL, Evangelista
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A, Filippini
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C, Gili
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R, Scarmozzino
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KM, Thorsell
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G, Delmar
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C. Identifying transitions in terminal illness trajectories: A critical factor in hospital-based palliative care. International Journal of Palliative Nursing. 2010; 16(2):87–92 [<a href="https://pubmed.ncbi.nlm.nih.gov/20220686" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20220686</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>23.</dt><dd><div class="bk_ref" id="ch1.ref23">Davis
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R. Starting end-of-life conversations in hospital. Nursing Times. 2015; 111(4):18–21 [<a href="https://pubmed.ncbi.nlm.nih.gov/26016115" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26016115</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>24.</dt><dd><div class="bk_ref" id="ch1.ref24">Dhiliwal
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S, Salins
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N, Deodhar
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J, Rao
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R, Muckaden
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MA. Pilot testing of triage coding system in home-based palliative care using Edmonton symptom assessment scale. Indian Journal of Palliative Care. 2016; 22(1):19–24 [<a href="/pmc/articles/PMC4768444/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4768444</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26962276" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26962276</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>25.</dt><dd><div class="bk_ref" id="ch1.ref25">Downar
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J, Goldman
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R, Pinto
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R, Englesakis
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M, Adhikari
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NK. The “surprise question” for predicting death in seriously ill patients: a systematic review and meta-analysis. CMAJ Canadian Medical Association Journal. 2017; 189(13):E484–E493 [<a href="/pmc/articles/PMC5378508/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5378508</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28385893" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28385893</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>26.</dt><dd><div class="bk_ref" id="ch1.ref26">Evans
|
|
RS, Benuzillo
|
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J, Horne
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BD, Lloyd
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JF, Bradshaw
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A, Budge
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et al. Automated identification and predictive tools to help identify high-risk heart failure patients: pilot evaluation. Journal of the American Medical Informatics Association. 2016; 23(5):872–878 [<a href="https://pubmed.ncbi.nlm.nih.gov/26911827" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26911827</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>27.</dt><dd><div class="bk_ref" id="ch1.ref27">Fenning
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S, Woolcock
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R, Haga
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K, Iqbal
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J, Fox
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KA, Murray
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SA
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et al. Identifying acute coronary syndrome patients approaching end-of-life. PloS One. 2012; 7(4):e35536 [<a href="/pmc/articles/PMC3329478/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3329478</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22530044" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22530044</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>28.</dt><dd><div class="bk_ref" id="ch1.ref28">Feyi
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K, Klinger
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S, Pharro
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G, McNally
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L, James
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A, Gretton
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K
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et al. Predicting palliative care needs and mortality in end stage renal disease: use of an at-risk register. BMJ Supportive & Palliative Care. 2015; 5(1):19–25 [<a href="https://pubmed.ncbi.nlm.nih.gov/24644161" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24644161</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>29.</dt><dd><div class="bk_ref" id="ch1.ref29">Fromme
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EK, Smith
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MD, Bascom
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PB, Kenworthy-Heinige
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T, Lyons
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KS, Tolle
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SW. Incorporating routine survival prediction in a U.S. hospital-based palliative care service. Journal of Palliative Medicine. 2010; 13(12):1439–1444 [<a href="/pmc/articles/PMC3014755/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3014755</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21128821" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21128821</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>30.</dt><dd><div class="bk_ref" id="ch1.ref30">Glajchen
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M, Lawson
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R, Homel
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P, Todd
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KH. A rapid two-stage screening protocol for palliative care in the emergency department: A quality improvement initiative. Journal of Pain and Symptom Management. 2011; 42(5):657–662 [<a href="https://pubmed.ncbi.nlm.nih.gov/22045368" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22045368</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>31.</dt><dd><div class="bk_ref" id="ch1.ref31">Glare
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P, Virik
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S, Boult
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C, Bubolz
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T, Chiang
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L. Who will need long-term care? Creation and validation of an instrument that identifies older people at risk. Disease Management. 2004; 7(4):267–274 [<a href="https://pubmed.ncbi.nlm.nih.gov/15671784" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15671784</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>33.</dt><dd><div class="bk_ref" id="ch1.ref33">Grbich
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C, Maddocks
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I, Parker
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D, Brown
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M, Willis
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E, Piller
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N
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et al. Identification of patients with noncancer diseases for palliative care services. Palliative and Supportive Care. 2005; 3(1):5–14 [<a href="https://pubmed.ncbi.nlm.nih.gov/16594189" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16594189</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>34.</dt><dd><div class="bk_ref" id="ch1.ref34">Greiner
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L, Buhr
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B, Phelps
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D, Ward
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S. A palliative care needs assessment of health care institutions in Wisconsin. Journal of Palliative Medicine. 2003; 6(4):543–556 [<a href="https://pubmed.ncbi.nlm.nih.gov/14516496" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14516496</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>35.</dt><dd><div class="bk_ref" id="ch1.ref35">Gwilliam
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B, Keeley
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V, Todd
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C, Roberts
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C, Gittins
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M, Kelly
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et al. Prognosticating in patients with advanced cancer--observational study comparing the accuracy of clinicians’ and patients’ estimates of survival. Annals of Oncology. 2013; 24(2):482–488 [<a href="https://pubmed.ncbi.nlm.nih.gov/23028038" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23028038</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>36.</dt><dd><div class="bk_ref" id="ch1.ref36">Haga
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K, Murray
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S, Reid
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J, Ness
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A, O’Donnell
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M, Yellowlees
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J, Morita
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T, Inoue
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S, Ikenaga
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M, Matsumoto
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Y, Sekine
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et al. Surprise questions for survival prediction in patients with advanced cancer: A multicenter prospective cohort study. Oncologist. 2015; 20(7):839–844 [<a href="/pmc/articles/PMC4492240/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4492240</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26054631" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26054631</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>38.</dt><dd><div class="bk_ref" id="ch1.ref38">Harrison
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N, Cavers
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D, Campbell
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C, Murray
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SA. Are UK primary care teams formally identifying patients for palliative care before they die?
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SA, Almeder
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L, Michalakes
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L, Han
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PKJ, Strout
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TD. Using the Surprise Question To Identify Those with Unmet Palliative Care Needs in Emergency and Inpatient Settings: What Do Clinicians Think?
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MC, Fishman
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PA, Ritzwoller
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DP, Elston-Lafata
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J, O’Keeffe-Rosetti
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MC, Salloum
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RG. When does an episode of care for cancer begin?
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A, Agar
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M, Lobb
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E, Davidson
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PM, Phillips
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J. Palliative care nurses’ recognition and assessment of patients with delirium symptoms: A qualitative study using critical incident technique. International Journal of Nursing Studies. 2014; 51(10):1353–1365 [<a href="https://pubmed.ncbi.nlm.nih.gov/24630378" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24630378</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>42.</dt><dd><div class="bk_ref" id="ch1.ref42">Hui
|
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D, Meng
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YC, Bruera
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S, Geng
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Y, Hutchins
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R, Mori
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TJ, Christakis
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NA. Signs of death. Journal of Palliative Medicine. 2001; 4(4):451–452 [<a href="https://pubmed.ncbi.nlm.nih.gov/11798475" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11798475</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>44.</dt><dd><div class="bk_ref" id="ch1.ref44">Janssen
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|
DJ, Spruit
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MA, Schols
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JM, Cox
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B, Nawrot
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TS, Curtis
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JR
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et al. Predicting changes in preferences for life-sustaining treatment among patients with advanced chronic organ failure. Chest. 2012; 141(5):1251–1259 [<a href="https://pubmed.ncbi.nlm.nih.gov/22016488" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22016488</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>45.</dt><dd><div class="bk_ref" id="ch1.ref45">Jenko
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M, Adams
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JA, Johnson
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CM, Thompson
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JA, Bailey
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DE, Jr. Facilitating palliative care referrals in the intensive care unit: A pilot project. DCCN - Dimensions of Critical Care Nursing. 2015; 34(6):329–339 [<a href="https://pubmed.ncbi.nlm.nih.gov/26436297" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26436297</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>46.</dt><dd><div class="bk_ref" id="ch1.ref46">Joanne
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R, Sue
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C. How to implement the Gold Standards Framework to ensure continuity of care. Nursing Times. 2010; 17(8):10–13 [<a href="https://pubmed.ncbi.nlm.nih.gov/20879638" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20879638</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>47.</dt><dd><div class="bk_ref" id="ch1.ref47">Johnson
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|
M, Nunn
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A, Hawkes
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T, Stockdale
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S, Daley
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A. Planning for end-of-life care in heart failure: Experience of two integrated cardiology-palliative care teams. British Journal of Cardiology. 2012; 19(2):71–75</div></dd></dl><dl class="bkr_refwrap"><dt>48.</dt><dd><div class="bk_ref" id="ch1.ref48">Johnston
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GM, Gibbons
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L, Burge
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FI, Dewar
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RA, Cummings
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I, Levy
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IG. Identifying potential need for cancer palliation in Nova Scotia. CMAJ Canadian Medical Association Journal. 1998; 158(13):1691–1698 [<a href="/pmc/articles/PMC1229439/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1229439</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/9676544" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9676544</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>49.</dt><dd><div class="bk_ref" id="ch1.ref49">Kennedy
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C, Brooks-Young
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|
P, Brunton Gray
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C, Larkin
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P, Connolly
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M, Wilde-Larsson
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LJ, Aoun
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SM, Yates
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|
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U, Dusterdiek
|
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A, Galushko
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M, Dose
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C, Montag
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T, Ostgathe
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|
M, Rhondali
|
|
W, Lafumas
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V, Berthiller
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J, Teissere
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M, Piegay
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|
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B, Van den Eynden
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B, Gielen
|
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B, Bastiaens
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H, Wens
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J. Implementation of a Care Pathway for Primary Palliative Care in 5 research clusters in Belgium: Quasi-experimental study protocol and innovations in data collection (pro-SPINOZA). BMC Palliative Care. 2015; 14:46 [<a href="/pmc/articles/PMC4585994/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4585994</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26416574" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26416574</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>54.</dt><dd><div class="bk_ref" id="ch1.ref54">Llobera
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J, Esteva
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M, Rifa
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J, Benito
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E, Terrasa
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J, Rojas
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J, Schall
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MW, Milne
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C, Nolan
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KM, Kabcenell
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A. Quality improvements in end of life care: insights from two collaboratives. Joint Commission Journal on Quality Improvement. 2000; 26(5):254–267 [<a href="https://pubmed.ncbi.nlm.nih.gov/18350770" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18350770</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>56.</dt><dd><div class="bk_ref" id="ch1.ref56">Maas
|
|
EA, Murray
|
|
SA, Engels
|
|
Y, Campbell
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C. What tools are available to identify patients with palliative care needs in primary care: a systematic literature review and survey of European practice. BMJ Supportive and Palliative Care. 2013; 3(4):444–451 [<a href="https://pubmed.ncbi.nlm.nih.gov/24950525" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24950525</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>57.</dt><dd><div class="bk_ref" id="ch1.ref57">Maguire
|
|
R, Kotronoulas
|
|
G, Papadopoulou
|
|
C, Simpson
|
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MF, McPhelim
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J, Irvine
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|
|
FC, Cabrera
|
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MA, Perilla
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AB, Brun
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MM, de Barros
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EM, Martins
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VM
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|
|
B, Buckingham
|
|
S, Finucane
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A, Hutchison
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P, Kendall
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M, McCutcheon
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C, Rucker
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G, Hatami
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I, Becker
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G. Identification of hospital patients in need of palliative care--a predictive score. BMC Palliative Care. 2016; 15:21 [<a href="/pmc/articles/PMC4763405/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4763405</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26906043" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26906043</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>61.</dt><dd><div class="bk_ref" id="ch1.ref61">Mierendorf
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SM, Gidvani
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V. Palliative care in the emergency department. The Permanente journal. 2014; 18(2):77–85 [<a href="/pmc/articles/PMC4022562/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4022562</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24694318" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24694318</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>62.</dt><dd><div class="bk_ref" id="ch1.ref62">Milnes
|
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S, Orford
|
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NR, Berkeley
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L, Lambert
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N, Simpson
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N, Elderkin
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C, Iqbal
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J, Murray
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S, Bertaina
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M, Parviz
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|
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C, Quadri
|
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G, D’Ascenzo
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F, Bertaina
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M, Giusto
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T, Fujimoto
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K, Namba
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M, Sasaki
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N, Ito
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T, Yamada
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SA, Kendall
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M, Mitchell
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G, Moine
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S, Amblas-Novellas
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J, Boyd
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SA, Hogan
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LA, Holloway
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RG, Temkin-Greener
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A, Laking
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G, Frey
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R, Robinson
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PA. The benefits of a hospital-based inpatient palliative care consultation service: preliminary outcome data. Journal of Palliative Medicine. 2005; 8(5):1033–1039 [<a href="https://pubmed.ncbi.nlm.nih.gov/16238516" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16238516</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>71.</dt><dd><div class="bk_ref" id="ch1.ref71">Philip
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JA, Le
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BH, Whittall
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D, Kearney
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J. The development and evaluation of an inpatient palliative care admission triage tool. Journal of Palliative Medicine. 2010; 13(8):965–972 [<a href="https://pubmed.ncbi.nlm.nih.gov/20649453" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20649453</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>72.</dt><dd><div class="bk_ref" id="ch1.ref72">Phua
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TY, Ho
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S, Yang
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G. Identifying screening criteria for a palliative care referral. Journal of Pain and Symptom Management. 2016; 52(6):e155–e156</div></dd></dl><dl class="bkr_refwrap"><dt>73.</dt><dd><div class="bk_ref" id="ch1.ref73">Public Health England. What we know now 2013: New information collated by the National End of Life Care Intelligence Network. London. Public Health England, 2013. Available from: <a href="http://www.endoflifecare-intelligence.org.uk/resources/publications/what_we_know_now_2013" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.endoflifecare-intelligence<wbr style="display:inline-block"></wbr>​.org<wbr style="display:inline-block"></wbr>​.uk/resources/publications<wbr style="display:inline-block"></wbr>​/what_we_know_now_2013</a></div></dd></dl><dl class="bkr_refwrap"><dt>74.</dt><dd><div class="bk_ref" id="ch1.ref74">Rainone
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F, Blank
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A, Selwyn
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PA. The early identification of palliative care patients: preliminary processes and estimates from urban, family medicine practices. American Journal of Hospice & Palliative Medicine. 2007; 24(2):137–140 [<a href="https://pubmed.ncbi.nlm.nih.gov/17502439" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17502439</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>75.</dt><dd><div class="bk_ref" id="ch1.ref75">Riggs
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A, Breuer
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B, Dhingra
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L, Chen
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J, Hiney
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B, McCarthy
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GB, Campbell
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TC, Johnson
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SK, King
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J, Zander
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MR, Quale
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RM
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|
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E, Schultz
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R, Linsalata
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HH, Sumberg
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D, Christensen
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M, Robinson
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|
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Y, Crowley-Matoka
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M, Dohan
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D, Rabow
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MW, Smith
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CB, White
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DB
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P, Carey
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M, Love
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C, Wein
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H, Snyder
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CF, Mularski
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RA, Shugarman
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LR, Kutner
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JS, Lorenz
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KA
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KM, Mohammed
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MA, Harriman
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P, Girolami
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A, Downes
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TW. Timely care for frail older people referred to hospital improves efficiency and reduces mortality without the need for extra resources. Age and Ageing. 2014; 43(4):472–477 [<a href="https://pubmed.ncbi.nlm.nih.gov/24222658" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24222658</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>84.</dt><dd><div class="bk_ref" id="ch1.ref84">Slaven
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M, Wylie
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B, Henderson
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N, Taylor
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S. Who needs a palliative care consult?: The Hamilton Chart Audit tool. Journal of Palliative Medicine. 2007; 10(2):304–307 [<a href="https://pubmed.ncbi.nlm.nih.gov/17472499" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17472499</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>85.</dt><dd><div class="bk_ref" id="ch1.ref85">Smith
|
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LE, Moore
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E, Ali
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I, Smeeth
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L, Stone
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P, Quint
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JK. Prognostic variables and scores identifying the end of life in COPD: A systematic review. International Journal of COPD. 2017; 12:2239–2256 [<a href="/pmc/articles/PMC5546187/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5546187</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28814852" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28814852</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>86.</dt><dd><div class="bk_ref" id="ch1.ref86">Smith
|
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LJ, Ali
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I, Stone
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P, Smeeth
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L, Quint
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JK. Prognostic variables and scores identifying the last year of life in COPD: A systematic review protocol. BMJ Open. 2016; 6(9):e011677 [<a href="/pmc/articles/PMC5030546/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5030546</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27633634" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27633634</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>87.</dt><dd><div class="bk_ref" id="ch1.ref87">Strupp
|
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J, Golla
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H, Galushko
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M, Buecken
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R, Ernstmann
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N, Hahn
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|
|
MK, Vaughn
|
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J, McLaughlin
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B, Mulvenon
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C, Porter-Williamson
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K, Sydenstricker
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|
|
PY, Tung
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EE, Crane
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SJ, Chaudhry
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R, Cha
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S, Hanson
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B, Groot
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M, Verhagen
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S, van Weel
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C, Vissers
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K, Engels
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Y. Timely identification of palliative patients and anticipatory care planning by GPs: Practical application of tools and a training programme. BMC Palliative Care. 2016; 15:39 [<a href="/pmc/articles/PMC4820918/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4820918</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27044254" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27044254</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>91.</dt><dd><div class="bk_ref" id="ch1.ref91">Trueman
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|
|
G, Van Belle
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S, De Laat
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M, Surmont
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|
V, Geboes
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K, Eecloo
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K
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et al. The systematic early integration of palliative care into multidisciplinary oncology care in the hospital setting (IPAC), a randomized controlled trial: The study protocol. BMC Health Services Research. 2015; 15:554 [<a href="/pmc/articles/PMC4678668/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4678668</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26666301" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26666301</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>93.</dt><dd><div class="bk_ref" id="ch1.ref93">Villa
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G, De Gaudio
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AR, Falsini
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S, Lanini
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I, Curtis
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JR. Development of END-of-Life ScorING-System to identify critically ill patients after initial critical care who are highly likely to die: a pilot study. Minerva Anestesiologica. 2015; 81(12):1318–1328 [<a href="https://pubmed.ncbi.nlm.nih.gov/25616205" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25616205</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>94.</dt><dd><div class="bk_ref" id="ch1.ref94">Vrijmoeth
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C, Christians
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MGM, Festen
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DAM, Groot
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M, Tonino
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M, Echteld
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MA. Physicians’ recognition of death in the foreseeable future in patients with intellectual disabilities. Journal of Intellectual Disability Research. 2016; 60(3):207–217 [<a href="https://pubmed.ncbi.nlm.nih.gov/26757410" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26757410</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>95.</dt><dd><div class="bk_ref" id="ch1.ref95">Waller
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A, Girgis
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A, Johnson
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C, Lecathelinais
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C, Sibbritt
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D, Seldon
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M
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et al. Implications of a needs assessment intervention for people with progressive cancer: Impact on clinical assessment, response and service utilisation. Psycho-Oncology. 2012; 21(5):550–557 [<a href="https://pubmed.ncbi.nlm.nih.gov/22517737" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22517737</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>96.</dt><dd><div class="bk_ref" id="ch1.ref96">Walshe
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C, Chew-Graham
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C, Todd
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C, Caress
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A. What influences referrals within community palliative care services? A qualitative case study. Social Science and Medicine. 2008; 67(1):137–146 [<a href="https://pubmed.ncbi.nlm.nih.gov/18433963" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18433963</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>97.</dt><dd><div class="bk_ref" id="ch1.ref97">White
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N, Kupeli
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N, Vickerstaff
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V, Stone
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P. How accurate is the ‘Surprise Question’ at identifying patients at the end of life? A systematic review and meta-analysis. BMC Medicine. 2017; 15:139 [<a href="/pmc/articles/PMC5540432/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5540432</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28764757" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28764757</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>98.</dt><dd><div class="bk_ref" id="ch1.ref98">White
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N, Reid
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F, Harris
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A, Harries
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P, Stone
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P. A systematic review of predictions of survival in palliative care: How accurate are clinicians and who are the experts?
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PloS One. 2016; 11(8):e0161407 [<a href="/pmc/articles/PMC4999179/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4999179</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27560380" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27560380</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>99.</dt><dd><div class="bk_ref" id="ch1.ref99">Yamada
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T, Morita
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T, Maeda
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I, Inoue
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S, Ikenaga
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M, Matsumoto
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Y
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et al. A prospective, multicenter cohort study to validate a simple performance status-based survival prediction system for oncologists. Cancer. 2017; 123(8):1442–1452 [<a href="https://pubmed.ncbi.nlm.nih.gov/27926777" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27926777</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>100.</dt><dd><div class="bk_ref" id="ch1.ref100">Zare
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F, Jackson
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WC. Who needs palliative care? Using the palliative performance scale to screen for palliative consultations (772). Journal of Pain and Symptom Management. 2011; 41(1):316–317</div></dd></dl></dl></div><div id="appendixesappgroup1"><h2 id="_appendixesappgroup1_">Appendices</h2><div id="ch1.appa"><h3>Appendix A. Review protocols</h3><p id="ch1.appa.tab1"><a href="/books/NBK558773/table/ch1.appa.tab1/?report=objectonly" target="object" rid-ob="figobch1appatab1" class="figpopup">Table 4. Review protocol for what are the best service models to support the identification of people who may be entering the last year of life</a></p><p id="ch1.appa.tab2"><a href="/books/NBK558773/table/ch1.appa.tab2/?report=objectonly" target="object" rid-ob="figobch1appatab2" class="figpopup">Table 5. Health economic review protocol</a></p></div><div id="ch1.appb"><h3>Appendix B. Literature search strategies</h3><p>The literature searches for this review are detailed below and complied with the methodology outlined in Developing NICE guidelines: the manual 2014, updated 2017 <a href="https://www.nice.org.uk/guidance/pmg20/resources/developing-nice-guidelines-the-manual-pdf-72286708700869" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www.nice.org.uk/guidance/pmg20/resources/developing-nice-guidelines-the-manual-pdf-72286708700869</a></p><p><i>For more detailed information, please see the</i>
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<a href="/books/NBK558773/bin/bm1.pdf">Methodology</a>
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<i>Review</i>.</p><div id="ch1.appb.s1"><h4>B.1. Clinical search literature search strategy</h4><p>Searches for were constructed using a PICO framework where population (P) terms were combined with Intervention (I) and in some cases Comparison (C) terms. Outcomes (O) are rarely used in search strategies for interventions as these concepts may not be well described in title, abstract or indexes and therefore difficult to retrieve. Search filters were applied to the search where appropriate.</p><p id="ch1.appb.tab1"><a href="/books/NBK558773/table/ch1.appb.tab1/?report=objectonly" target="object" rid-ob="figobch1appbtab1" class="figpopup">Table 6. Database date parameters and filters used</a></p><p id="ch1.appb.tab2"><a href="/books/NBK558773/table/ch1.appb.tab2/?report=objectonly" target="object" rid-ob="figobch1appbtab2" class="figpopup">Medline (Ovid) search terms</a></p><p id="ch1.appb.tab3"><a href="/books/NBK558773/table/ch1.appb.tab3/?report=objectonly" target="object" rid-ob="figobch1appbtab3" class="figpopup">Embase (Ovid) search terms</a></p><p id="ch1.appb.tab4"><a href="/books/NBK558773/table/ch1.appb.tab4/?report=objectonly" target="object" rid-ob="figobch1appbtab4" class="figpopup">Cochrane Library (Wiley) search terms</a></p><p id="ch1.appb.tab5"><a href="/books/NBK558773/table/ch1.appb.tab5/?report=objectonly" target="object" rid-ob="figobch1appbtab5" class="figpopup">CINAHL (EBSCO) search terms</a></p><p id="ch1.appb.tab6"><a href="/books/NBK558773/table/ch1.appb.tab6/?report=objectonly" target="object" rid-ob="figobch1appbtab6" class="figpopup">PsycINFO (ProQuest) search terms</a></p><p id="ch1.appb.tab7"><a href="/books/NBK558773/table/ch1.appb.tab7/?report=objectonly" target="object" rid-ob="figobch1appbtab7" class="figpopup">HMIC (Ovid) search terms</a></p><p id="ch1.appb.tab8"><a href="/books/NBK558773/table/ch1.appb.tab8/?report=objectonly" target="object" rid-ob="figobch1appbtab8" class="figpopup">SPP (Ovid) search terms</a></p><p id="ch1.appb.tab9"><a href="/books/NBK558773/table/ch1.appb.tab9/?report=objectonly" target="object" rid-ob="figobch1appbtab9" class="figpopup">ASSIA (ProQuest) search terms</a></p></div><div id="ch1.appb.s2"><h4>B.2. Health Economics literature search strategy</h4><p>Health economic evidence was identified by conducting a broad search relating to end of life care in NHS Economic Evaluation Database (NHS EED – this ceased to be updated after March 2015) and the Health Technology Assessment database (HTA) with no date restrictions. NHS EED and HTA databases are hosted by the Centre for Research and Dissemination (CRD). Additional searches were run on Medline and Embase for health economics, economic modelling and quality of life studies.</p><p id="ch1.appb.tab10"><a href="/books/NBK558773/table/ch1.appb.tab10/?report=objectonly" target="object" rid-ob="figobch1appbtab10" class="figpopup">Table 7. Database date parameters and filters used</a></p><p id="ch1.appb.tab11"><a href="/books/NBK558773/table/ch1.appb.tab11/?report=objectonly" target="object" rid-ob="figobch1appbtab11" class="figpopup">Medline (Ovid) search terms</a></p><p id="ch1.appb.tab12"><a href="/books/NBK558773/table/ch1.appb.tab12/?report=objectonly" target="object" rid-ob="figobch1appbtab12" class="figpopup">Embase (Ovid) search terms</a></p><p id="ch1.appb.tab13"><a href="/books/NBK558773/table/ch1.appb.tab13/?report=objectonly" target="object" rid-ob="figobch1appbtab13" class="figpopup">NHS EED and HTA (CRD) search terms</a></p></div></div><div id="ch1.appc"><h3>Appendix C. Clinical evidence selection</h3><p id="ch1.appc.fig1"><a href="/books/NBK558773/figure/ch1.appc.fig1/?report=objectonly" target="object" rid-ob="figobch1appcfig1" class="figpopup">Figure 1. Flow chart of clinical study selection for the review of what are the best service models to support the identification of people who may be entering the last year of life?</a></p><p id="ch1.appc.fig2"><a href="/books/NBK558773/figure/ch1.appc.fig2/?report=objectonly" target="object" rid-ob="figobch1appcfig2" class="figpopup">Figure 2. Flow chart of health economic study selection for the guideline</a></p></div><div id="ch1.appd"><h3>Appendix D. Clinical evidence tables</h3><p id="ch1.appd.et1"><a href="/books/NBK558773/bin/ch1-appd-et1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Download PDF</a><span class="small"> (137K)</span></p></div><div id="ch1.appe"><h3>Appendix E. Forest plots</h3><div id="ch1.appe.s1"><h4>E.1. Proactive case-finding versus no intervention</h4><p id="ch1.appe.fig3"><a href="/books/NBK558773/figure/ch1.appe.fig3/?report=objectonly" target="object" rid-ob="figobch1appefig3" class="figpopup">Figure 3. Proactive case-finding versus no intervention in end of life care: length of stay in hospital (days)</a></p><p id="ch1.appe.fig4"><a href="/books/NBK558773/figure/ch1.appe.fig4/?report=objectonly" target="object" rid-ob="figobch1appefig4" class="figpopup">Figure 4. Proactive case-finding versus no intervention in end of life care: length of MICU stay (days)</a></p><p id="ch1.appe.fig5"><a href="/books/NBK558773/figure/ch1.appe.fig5/?report=objectonly" target="object" rid-ob="figobch1appefig5" class="figpopup">Figure 5. Proactive case-finding versus no intervention in end of life care: discharge to another hospital</a></p></div></div><div id="ch1.appf"><h3>Appendix F. GRADE tables</h3><p id="ch1.appf.tab1"><a href="/books/NBK558773/table/ch1.appf.tab1/?report=objectonly" target="object" rid-ob="figobch1appftab1" class="figpopup">Table 8. Clinical evidence profile: Proactive case-finding versus no intervention</a></p></div><div id="ch1.appg"><h3>Appendix G. Excluded studies</h3><div id="ch1.appg.s1"><h4>G.1. Excluded clinical studies</h4><p id="ch1.appg.tab1"><a href="/books/NBK558773/table/ch1.appg.tab1/?report=objectonly" target="object" rid-ob="figobch1appgtab1" class="figpopup">Table 9. Studies excluded from the clinical review</a></p></div><div id="ch1.appg.s2"><h4>G.2. Excluded economic studies</h4><p>There were no excluded economic studies for this review.</p></div></div></div></div><div class="fm-sec"><div><p>Final</p></div><div><p>Evidence review</p><p>Developed by the National Guideline Centre, hosted by the Royal College of Physicians</p></div><div><p><b>Disclaimer</b>: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.</p><p>Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.</p><p>NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the <a href="http://wales.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Welsh Government</a>, <a href="http://www.scotland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Scottish Government</a>, and <a href="http://www.northernireland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Northern Ireland Executive</a>. All NICE guidance is subject to regular review and may be updated or withdrawn.</p></div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2019.</div><div class="small"><span class="label">Bookshelf ID: NBK558773</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32614546" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">32614546</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article><article data-type="table-wrap" id="figobch1tab1"><div id="ch1.tab1" class="table"><h3><span class="label">Table 1</span><span class="title">PICO characteristics of review question</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.tab1_lrgtbl__"><table><tbody><tr><th id="hd_b_ch1.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><td headers="hd_b_ch1.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l1"><li id="ch1.lt1" class="half_rhythm"><div>Adults (aged 18 or over) with progressive life-limiting conditions thought to be entering the last year of life.</div></li><li id="ch1.lt2" class="half_rhythm"><div>Carers, or those important to, adults (aged 18 or over) with progressive life-limiting conditions thought to be entering the last year of life.</div></li><li id="ch1.lt3" class="half_rhythm"><div>Carers (under 18 years old) of adults (aged 18 or over) with progressive life-limiting conditions thought to be entering the last year of life</div></li></ul>
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</td></tr><tr><th id="hd_b_ch1.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interventions</th><td headers="hd_b_ch1.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l2"><li id="ch1.lt4" class="half_rhythm"><div>Methods, systems or policies to support identification of people who may be entering the last year of life and/or their carers: for example:
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<ul id="ch1.l3" class="circle"><li id="ch1.lt5" class="half_rhythm"><div>Proactive care</div></li><li id="ch1.lt6" class="half_rhythm"><div>Centralised records</div></li><li id="ch1.lt7" class="half_rhythm"><div>Gold standard framework</div></li><li id="ch1.lt8" class="half_rhythm"><div>AMBER care bundle</div></li><li id="ch1.lt9" class="half_rhythm"><div>Electronic discharge notifications</div></li><li id="ch1.lt10" class="half_rhythm"><div>Video-conferencing</div></li><li id="ch1.lt11" class="half_rhythm"><div>Multidisciplinary meetings</div></li><li id="ch1.lt12" class="half_rhythm"><div>Virtual hospital/ward rounds</div></li><li id="ch1.lt13" class="half_rhythm"><div>Established routines for handovers and exchange of information</div></li></ul></div></li></ul>
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</td></tr><tr><th id="hd_b_ch1.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparisons</th><td headers="hd_b_ch1.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l4"><li id="ch1.lt14" class="half_rhythm"><div>Combination of methods, systems or policies to support identification of people who may be entering the last year of life, or their carers</div></li><li id="ch1.lt15" class="half_rhythm"><div>To each other</div></li><li id="ch1.lt16" class="half_rhythm"><div>No established method to support identification</div></li></ul>
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</td></tr><tr><th id="hd_b_ch1.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes</th><td headers="hd_b_ch1.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL
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<ul id="ch1.l5"><li id="ch1.lt17" class="half_rhythm"><div>Quality of life of person in their last year of life (Continuous)</div></li><li id="ch1.lt18" class="half_rhythm"><div>Quality of life of carer of (or person important to) the person in their last year of life (Continuous)</div></li><li id="ch1.lt19" class="half_rhythm"><div>Preferred and actual place of death (Dichotomous)</div></li><li id="ch1.lt20" class="half_rhythm"><div>Preferred and actual place of care (Dichotomous)</div></li><li id="ch1.lt21" class="half_rhythm"><div>Longevity of carer (Continuous)</div></li></ul>
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IMPORTANT
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<ul id="ch1.l6"><li id="ch1.lt22" class="half_rhythm"><div>Length of stay (Continuous)</div></li><li id="ch1.lt23" class="half_rhythm"><div>Length of survival (Continuous)</div></li><li id="ch1.lt24" class="half_rhythm"><div>Hospitalisation (Dichotomous)</div></li><li id="ch1.lt25" class="half_rhythm"><div>Number of hospital visits (Dichotomous)</div></li><li id="ch1.lt26" class="half_rhythm"><div>Number of visits to accident and emergency (Dichotomous)</div></li><li id="ch1.lt27" class="half_rhythm"><div>Number of unscheduled admissions (Dichotomous)</div></li><li id="ch1.lt28" class="half_rhythm"><div>Use of community services (Dichotomous)</div></li><li id="ch1.lt29" class="half_rhythm"><div>Avoidable/inappropriate admissions to ICU (Dichotomous)</div></li><li id="ch1.lt30" class="half_rhythm"><div>Inappropriate attempts at cardiopulmonary resuscitation (Dichotomous)</div></li><li id="ch1.lt31" class="half_rhythm"><div>Staff satisfaction (Continuous)</div></li><li id="ch1.lt32" class="half_rhythm"><div>Patient/carer reported outcomes (satisfaction) (Continuous)</div></li><li id="ch1.lt33" class="half_rhythm"><div>Carer health (for example: GP visits, mental health, school/work attendance) (Continuous/Dichotomous)</div></li></ul>
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</td></tr><tr><th id="hd_b_ch1.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch1.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l7"><li id="ch1.lt34" class="half_rhythm"><div>Systematic reviews</div></li><li id="ch1.lt35" class="half_rhythm"><div>RCTs</div></li><li id="ch1.lt36" class="half_rhythm"><div>Non-randomised comparative studies, including before and after studies and interrupted-time-series</div></li></ul>
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</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1tab2"><div id="ch1.tab2" class="table"><h3><span class="label">Table 2</span><span class="title">Summary of studies included in the evidence review</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch1.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch1.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Intervention and comparison</th><th id="hd_h_ch1.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Population</th><th id="hd_h_ch1.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch1.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Comments</th></tr></thead><tbody><tr><td headers="hd_h_ch1.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Campbell 2004<a class="bibr" href="#ch1.ref13" rid="ch1.ref13"><sup>13</sup></a></td><td headers="hd_h_ch1.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l8"><li id="ch1.lt37" class="half_rhythm"><div>Intervention: Proactive case-finding. Patients were screened daily for meeting the study criteria. Patients were identified and the patient’s surrogate or guardian was contacted for a meeting, and the patient’s prognosis was communicated and clarified as needed. A change of treatment goals to focus on comfort-oriented care was recommended and ventilation withdrawal.</div></li><li id="ch1.lt38" class="half_rhythm"><div>Comparison: No established method to support identification.</div></li></ul>
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</td><td headers="hd_h_ch1.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Patients with advanced-stage dementia in a medical intensive care unit (MICU) N=52 USA</td><td headers="hd_h_ch1.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l9"><li id="ch1.lt39" class="half_rhythm"><div>Length of hospital stay</div></li><li id="ch1.lt40" class="half_rhythm"><div>Length of MICU stay</div></li><li id="ch1.lt41" class="half_rhythm"><div>Discharged to another hospital</div></li></ul>
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</td><td headers="hd_h_ch1.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-randomised comparative study</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1tab3"><div id="ch1.tab3" class="table"><h3><span class="label">Table 3</span><span class="title">Clinical evidence summary: Proactive case-finding versus no intervention</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch1.tab3_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch1.tab3_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch1.tab3_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch1.tab3_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch1.tab3_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch1.tab3_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch1.tab3_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch1.tab3_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch1.tab3_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch1.tab3_1_1_1_5" id="hd_h_ch1.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with No intervention</th><th headers="hd_h_ch1.tab3_1_1_1_5" id="hd_h_ch1.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Proactive case-finding (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch1.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Length of stay (days)</td><td headers="hd_h_ch1.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>52</p>
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<p>(1 study)</p>
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</td><td headers="hd_h_ch1.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⊕⊝⊝⊝</p>
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<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
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<p>due to risk of bias, imprecision</p>
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</td><td headers="hd_h_ch1.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch1.tab3_1_1_1_5 hd_h_ch1.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch1.tab3_1_1_1_5 hd_h_ch1.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The mean length of hospital stay (days) in the intervention groups was 4.7 lower (8.87 to 0.53 lower)</td></tr><tr><td headers="hd_h_ch1.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Length of stay in MICU (days)</td><td headers="hd_h_ch1.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>52</p>
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<p>(1 study)</p>
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</td><td headers="hd_h_ch1.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⊕⊝⊝⊝</p>
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<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
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<p>due to risk of bias, imprecision</p>
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</td><td headers="hd_h_ch1.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch1.tab3_1_1_1_5 hd_h_ch1.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch1.tab3_1_1_1_5 hd_h_ch1.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The mean length of stay in MICU (days) in the intervention groups was 3.3 lower (5.46 to 1.14 lower)</td></tr><tr><td headers="hd_h_ch1.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Discharged to another hospital</td><td headers="hd_h_ch1.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>52</p>
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<p>(1 study)</p>
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</td><td headers="hd_h_ch1.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⊕⊝⊝⊝</p>
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<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
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<p>due to risk of bias, imprecision</p>
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</td><td headers="hd_h_ch1.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Peto OR 7.39 (0.15 to 372.38)</td><td headers="hd_h_ch1.tab3_1_1_1_5 hd_h_ch1.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 per 1000</td><td headers="hd_h_ch1.tab3_1_1_1_5 hd_h_ch1.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40 higher (from 60 lower to 140 higher)</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch1.tab3_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch1.tab3_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch1appatab1"><div id="ch1.appa.tab1" class="table"><h3><span class="label">Table 4</span><span class="title">Review protocol for what are the best service models to support the identification of people who may be entering the last year of life</span></h3><div class="caption"><p>Question number: 1</p><p>Relevant section of Scope: Service organisation that supports the identification of people thought to be entering the last year of life.</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appa.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appa.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ID</th><th id="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Field</th><th id="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Content</th></tr></thead><tbody><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">I</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review question</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">What are the best service models to support the identification of people who may be entering the last year of life</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">II</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Type of review question</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Intervention review.</p>
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<p>A review of health economic evidence related to the same review question was conducted in parallel with this review. For details see the health economic review protocol for this NICE guideline.</p>
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</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">III</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objective of the review</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To identify the best service models to support the identification of people who might be entering the last year of life and/or their carers (or those important to them)</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IV</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – population / disease / condition / issue / domain</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Adults (aged 18 or over) with progressive life-limiting conditions thought to be entering the last year of life and/or their carers (or those important to them);</p>
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<p>Carers of those (or those important to) adults (aged 18 or over) with progressive life-limiting conditions thought to be entering the last years of life;</p>
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<p>Carers (aged under 18) of adults (aged 18 or over) with progressive life-limiting conditions thought to be entering the last year of life.</p>
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</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">V</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – intervention(s) / exposure(s) / prognostic factor(s)</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods, systems or policies to support identification of people who may be entering the last year of life and/or their carers: for example,
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<ul id="ch1.l11"><li id="ch1.lt43" class="half_rhythm"><div>Proactive care</div></li><li id="ch1.lt44" class="half_rhythm"><div>Centralised records</div></li><li id="ch1.lt45" class="half_rhythm"><div>Gold standard framework</div></li><li id="ch1.lt46" class="half_rhythm"><div>AMBER care bundle</div></li><li id="ch1.lt47" class="half_rhythm"><div>Electronic discharge notifications</div></li><li id="ch1.lt48" class="half_rhythm"><div>Video-conferencing</div></li><li id="ch1.lt49" class="half_rhythm"><div>Multidisciplinary meetings</div></li><li id="ch1.lt50" class="half_rhythm"><div>Virtual hospital/ward rounds</div></li></ul>
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Established routines for handovers and exchange of information</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VI</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – comparator(s) / control or reference (gold) standard</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l12"><li id="ch1.lt51" class="half_rhythm"><div>Combination of methods, systems or policies to support identification of people who may be entering the last year of life, or their carers</div></li><li id="ch1.lt52" class="half_rhythm"><div>To each other</div></li><li id="ch1.lt53" class="half_rhythm"><div>No established method to support identification</div></li></ul></td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes and prioritisation</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL
|
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<ul id="ch1.l13"><li id="ch1.lt54" class="half_rhythm"><div>Quality of life of person in their last year of life (Continuous)</div></li><li id="ch1.lt55" class="half_rhythm"><div>Quality of life of carer of (or person important to) the person in their last year of life (Continuous)</div></li><li id="ch1.lt56" class="half_rhythm"><div>Preferred and actual place of death (Dichotomous)</div></li><li id="ch1.lt57" class="half_rhythm"><div>Preferred and actual place of care (Dichotomous)</div></li><li id="ch1.lt58" class="half_rhythm"><div>Longevity of carer (Continuous)</div></li></ul>
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IMPORTANT
|
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<ul id="ch1.l14"><li id="ch1.lt59" class="half_rhythm"><div>Length of stay (Continuous)</div></li><li id="ch1.lt60" class="half_rhythm"><div>Length of survival (Continuous)</div></li><li id="ch1.lt61" class="half_rhythm"><div>Hospitalisation (Dichotomous)</div></li><li id="ch1.lt62" class="half_rhythm"><div>Number of hospital visits (Dichotomous)</div></li><li id="ch1.lt63" class="half_rhythm"><div>Number of visits to accident and emergency (Dichotomous)</div></li><li id="ch1.lt64" class="half_rhythm"><div>Number of unscheduled admissions (Dichotomous)</div></li><li id="ch1.lt65" class="half_rhythm"><div>Use of community services (Dichotomous)</div></li><li id="ch1.lt66" class="half_rhythm"><div>Avoidable/inappropriate admissions to ICU (Dichotomous)</div></li><li id="ch1.lt67" class="half_rhythm"><div>Inappropriate attempts at cardiopulmonary resuscitation (Dichotomous)</div></li><li id="ch1.lt68" class="half_rhythm"><div>Staff satisfaction (Continuous)</div></li><li id="ch1.lt69" class="half_rhythm"><div>Patient/carer reported outcomes (satisfaction) (Continuous)</div></li><li id="ch1.lt70" class="half_rhythm"><div>Carer health (for example: GP visits, mental health, school/work attendance) (Continuous/Dichotomous)</div></li></ul></td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VIII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – study design</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l15"><li id="ch1.lt71" class="half_rhythm"><div>Systematic reviews</div></li><li id="ch1.lt72" class="half_rhythm"><div>RCTs</div></li><li id="ch1.lt73" class="half_rhythm"><div>Non-randomised comparative studies, including before and after studies and interrupted-time-series</div></li></ul></td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IX</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other inclusion exclusion criteria</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l16"><li id="ch1.lt74" class="half_rhythm"><div>Children and young people (17 years or younger) in their last year of life</div></li><li id="ch1.lt75" class="half_rhythm"><div>Studies will only be included if they reported one of more of the outcomes listed above</div></li><li id="ch1.lt76" class="half_rhythm"><div>Descriptive (non-comparative) studies will be excluded</div></li></ul></td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">X</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Proposed sensitivity / subgroup analysis, or meta-regression</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not applicable.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XI</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Selection process – duplicate screening / selection / analysis</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>Quality assurance will be undertaken by a senior research fellow prior to completion.</p>
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<p>Review strategy/other analysis:
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<ul id="ch1.l17"><li id="ch1.lt77" class="half_rhythm"><div>Information on identification tools used as part of a service will be extracted.</div></li><li id="ch1.lt78" class="half_rhythm"><div>Due to the expected complexity of the service models implemented in the studies, studies will be reported separately if necessary. In such case, studies on the populations included in the subgroup list will be highlighted to the Committee and will be considered when making the recommendations</div></li></ul></p>
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</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data management (software)</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch1.l18"><li id="ch1.lt79" class="half_rhythm"><div>Pairwise meta-analyses were performed using Cochrane Review Manager (RevMan5).</div></li><li id="ch1.lt80" class="half_rhythm"><div>GRADEpro was used to assess the quality of evidence for each outcome.</div></li><li id="ch1.lt81" class="half_rhythm"><div>Endnote was used for:
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<ul id="ch1.l19" class="circle"><li id="ch1.lt82" class="half_rhythm"><div>Bibliography, citations, sifting and reference management</div></li></ul></div></li><li id="ch1.lt83" class="half_rhythm"><div>Evibase was used for
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<ul id="ch1.l20" class="circle"><li id="ch1.lt84" class="half_rhythm"><div>Data extraction and quality assessment / critical appraisal</div></li></ul></div></li></ul></td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XIII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Information sources – databases and dates</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>Clinical search databases to be used: Medline, Embase, Cochrane Library, Current Nursing and Allied Health Literature (CINAHL), PsycINFO, Healthcare Management Information Consortium (HMIC), Social Policy and Practice (SSP), Applied Social Sciences Index and Abstracts (ASSIA)</p>
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<p>Date: All years</p>
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<p>Health economics search databases to be used: Medline, Embase, NHSEED, HTA</p>
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<p>Date: Medline, Embase from 2014</p>
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<p>NHSEED, HTA – All years</p>
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<p>Language: Restrict to English only</p>
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</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XIV</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Identify if an update</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not applicable.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XV</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Author contacts</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XVI</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Highlight if amendment to previous protocol</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 4.5 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XVII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy – for one database</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see <a href="#ch1.appb">Appendix B</a></td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XVIII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data collection process – forms / duplicate</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A standardised evidence table format will be used, and published as append ices of the evidence report.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XIX</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data items – define all variables to be collected</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see evidence tables in <a href="#ch1.appd">Appendix D</a> (clinical evidence tables) or H (health economic evidence tables).</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XX</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for assessing bias at outcome / study level</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Standard study checklists were used to critically appraise individual studies. For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></p>
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<p>The risk of bias across all available evidence was evaluated for each outcome using an adaptation of the ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) toolbox’ developed by the international GRADE working group <a href="http://www.gradeworkinggroup.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.gradeworkinggroup.org/</a></p>
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</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXI</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Criteria for quantitative synthesis</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.4 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for quantitative analysis – combining studies and exploring (in)consistency</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the separate <a href="/books/NBK558773/bin/bm1.pdf">Methods</a> report for this guideline.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXIII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-bias assessment – publication bias, selective reporting bias</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</p>
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<p>[Consider exploring publication bias for review questions where it may be more common, such as pharmacological questions, certain disease areas. Describe any steps taken to mitigate against publication bias, such as examining trial registries.]</p>
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</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXIV</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Confidence in cumulative evidence</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see sections 6.4 and 9.1 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXV</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rationale / context – what is known</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the introduction to the evidence review.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXVI</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Describe contributions of authors and guarantor</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>A multidisciplinary committee</p><p>(<a href="https://www.nice.org.uk/guidance/indevelopment/gid-cgwave0799/documents" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.nice.org<wbr style="display:inline-block"></wbr>​.uk/guidance/indevelopment<wbr style="display:inline-block"></wbr>​/gid-cgwave0799/documents</a>) developed the evidence review. The committee was convened by the National Guideline Centre (NGC) and chaired by Mark in line with section 3 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</p>
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<p>Staff from NGC undertook systematic literature searches, appraised the evidence, conducted meta-analysis and cost-effectiveness analysis where appropriate, and drafted the evidence review in collaboration with the committee. For details please see <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</p></td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXVII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sources of funding / support</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NGC is funded by NICE and hosted by the Royal College of Physicians.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXVIII</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Name of sponsor</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NGC is funded by NICE and hosted by the Royal College of Physicians.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXIX</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Roles of sponsor</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE funds NGC to develop guidelines for those working in the NHS, public health and social care in England.</td></tr><tr><td headers="hd_h_ch1.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXX</td><td headers="hd_h_ch1.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PROSPERO registration number</td><td headers="hd_h_ch1.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not registered</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appatab2"><div id="ch1.appa.tab2" class="table"><h3><span class="label">Table 5</span><span class="title">Health economic review protocol</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appa.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appa.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch1.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Review question</th><th id="hd_h_ch1.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">All questions – health economic evidence</th></tr></thead><tbody><tr><td headers="hd_h_ch1.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objectives</td><td headers="hd_h_ch1.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To identify health economic studies relevant to any of the review questions.</td></tr><tr><td headers="hd_h_ch1.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search criteria</td><td headers="hd_h_ch1.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Populations, interventions and comparators must be as specified in the clinical review protocol above.</p>
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<p>Studies must be of a relevant health economic study design (cost–utility analysis, cost-effectiveness analysis, cost–benefit analysis, cost–consequences analysis, comparative cost analysis).</p>
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<p>Studies must not be a letter, editorial or commentary, or a review of health economic evaluations. (Recent reviews will be ordered although not reviewed. The bibliographies will be checked for relevant studies, which will then be ordered.)</p>
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<p>Unpublished reports will not be considered unless submitted as part of a call for evidence.</p>
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<p>Studies must be in English.</p>
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</td></tr><tr><td headers="hd_h_ch1.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy</td><td headers="hd_h_ch1.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A health economic study search will be undertaken using population-specific terms and a health economic study filter – see <a href="#ch1.appg">Appendix G</a> [in the Full guideline]</td></tr><tr><td headers="hd_h_ch1.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review strategy</td><td headers="hd_h_ch1.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Studies not meeting any of the search criteria above will be excluded. Studies published before 2007, abstract-only studies and studies from non-OECD countries or the USA will also be excluded.</p>
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<p>Each remaining study will be assessed for applicability and methodological limitations using the NICE economic evaluation checklist which can be found in Appendix H of Developing NICE guidelines: the manual (2014).<a class="bibr" href="#ch1.ref67" rid="ch1.ref67"><sup>67</sup></a></p>
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<p>Inclusion and exclusion criteria</p>
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<p>If a study is rated as both ‘Directly applicable’ and with ‘Minor limitations’ then it will be included in the guideline. A health economic evidence table will be completed and it will be included in the health economic evidence profile.</p>
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<p>If a study is rated as either ‘Not applicable’ or with ‘Very serious limitations’ then it will usually be excluded from the guideline. If it is excluded then a health economic evidence table will not be completed and it will not be included in the health economic evidence profile.</p>
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<p>If a study is rated as ‘Partially applicable’, with ‘Potentially serious limitations’ or both then there is discretion over whether it should be included.</p>
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<p>Where there is discretion</p>
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<p>The health economist will make a decision based on the relative applicability and quality of the available evidence for that question, in discussion with the guideline committee if required. The ultimate aim is to include health economic studies that are helpful for decision-making in the context of the guideline and the current NHS setting. If several studies are considered of sufficiently high applicability and methodological quality that they could all be included, then the health economist, in discussion with the committee if required, may decide to include only the most applicable studies and to selectively exclude the remaining studies. All studies excluded on the basis of applicability or methodological limitations will be listed with explanation as excluded health economic studies in Appendix M.</p>
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<p>The health economist will be guided by the following hierarchies.</p>
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<p>Setting:</p>
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<p>UK NHS (most applicable).</p>
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<p>OECD countries with predominantly public health insurance systems (for example, France, Germany, Sweden).</p>
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<p>OECD countries with predominantly private health insurance systems (for example, Switzerland).</p>
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<p>Studies set in non-OECD countries or in the USA will be excluded before being assessed for applicability and methodological limitations.</p>
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<p>Health economic study type:</p>
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<p>Cost–utility analysis (most applicable).</p>
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<p>Other type of full economic evaluation (cost–benefit analysis, cost-effectiveness analysis, cost–consequences analysis).</p>
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<p>Comparative cost analysis.</p>
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<p>Non-comparative cost analyses including cost-of-illness studies will be excluded before being assessed for applicability and methodological limitations.</p>
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<p>Year of analysis:</p>
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<p>The more recent the study, the more applicable it will be.</p>
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<p>Studies published in 2007 or later but that depend on unit costs and resource data entirely or predominantly from before 2007 will be rated as ‘Not applicable’. Studies published before 2007 will be excluded before being assessed for applicability and methodological limitations.</p>
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<p>Quality and relevance of effectiveness data used in the health economic analysis:</p>
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<p>The more closely the clinical effectiveness data used in the health economic analysis match with the outcomes of the studies included in the clinical review the more useful the analysis will be for decision-making in the guideline.</p>
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</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab1"><div id="ch1.appb.tab1" class="table"><h3><span class="label">Table 6</span><span class="title">Database date parameters and filters used</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Database</th><th id="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dates searched</th><th id="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Search filter used</th></tr></thead><tbody><tr><td headers="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medline (Ovid)</td><td headers="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1946 – 04 January 2019</td><td headers="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusions</td></tr><tr><td headers="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase (Ovid)</td><td headers="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1974 – 04 January 2019</td><td headers="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusions</td></tr><tr><td headers="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The Cochrane Library (Wiley)</td><td headers="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Cochrane Reviews to Issue 1 of 12, January 2019</p>
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<p>CENTRAL to Issue 1 of 12, January 2019</p>
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<p>DARE, and NHSEED to Issue 2 of 4 2015</p>
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<p>HTA to Issue 4 of 4 2016</p>
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</td><td headers="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr><tr><td headers="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CINAHL, Current Nursing and Allied Health Literature (EBSCO)</td><td headers="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inception – 04 January 2019</td><td headers="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Limiters - English Language; Exclude MEDLINE records; Publication Type: Clinical Trial, Journal Article, Meta Analysis, Randomized Controlled Trial, Systematic Review: Age Groups: All Adult; Language: English</td></tr><tr><td headers="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PsycINFO (ProQuest)</td><td headers="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inception – 04 January 2019</td><td headers="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study type</td></tr><tr><td headers="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HMIC. Healthcare Management Information Consortium (Ovid)</td><td headers="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1979 – 04 January 2019</td><td headers="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusions</td></tr><tr><td headers="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SPP, Social Policy and Practice</td><td headers="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1981 – 04 January 2019</td><td headers="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study types</td></tr><tr><td headers="hd_h_ch1.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ASSIA, Applied Social Sciences Index and Abstracts (ProQuest)</td><td headers="hd_h_ch1.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1987 – 04 January 2019</td><td headers="hd_h_ch1.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab2"><div id="ch1.appb.tab2" class="table"><h3><span class="title">Medline (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab2_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Palliative care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Terminal care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospice care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Terminally Ill/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 (care* or caring or ill*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nursing Homes/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Respite Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospices/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Continuity of Patient Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Physician-Patient Relations/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Long-Term Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Delivery of Health Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–26</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">news/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp historical article/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">comment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/28–35</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36 not 37</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animals, Laboratory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experimentation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Models, Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/38–44</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27 not 45</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 46 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47 not 48</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(commission* adj2 (support* or service* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((service* or program* or co-ordinat* or co ordinat* or coordinat*) adj2 (model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Critical Pathways/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((critical or clinic* or service* or care) adj2 path*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Patient Care Bundles/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(care adj2 (bundle* or service* or package* or standard*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/50–55</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(assess* or criteria* or predict* or recogni* or identif* or refer*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49 and 56 and 57</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">gold standard*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49 and 59</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(amber adj2 bundle).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58 or 60 or 61</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">patient care team/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">interdisciplinary communication/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((interdisciplin* or inter-disciplin* or interprofession* or inter-profession* or multidisciplin* or multi-disciplin* or multi-profession* or multiprofession* or transprofession* or trans-profession*) adj2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((integrat* or network*) adj2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(key adj2 work*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) adj2 (lead or leader or leads or facilitat*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) adj1 profession*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Case Management/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(case adj2 manage*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(co-ordinator* or coordinator* or coordinate* or co-ordinate*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/63–72</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“referral and consultation”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(referral* or referred or referring or refer or refers or consult*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(recommend* or direct*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/74–76</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Advance Care Planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/78–80</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Caregivers/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Spouses/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/82–85</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((replacement or break* or holiday* or respite) adj3 (care* or service*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((communit* or support* or psychosocial* or psycholog*) adj3 (service* or group* or system*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((group* or support* or psychosocial* or psycholog*) adj3 (selfhelp or self help or therap*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((psychosocial* or psycholog*) adj2 support*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-Help Groups/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp social support/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Counseling/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(counseling or counselling*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(buddy* or buddies).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((health* or medical*) adj2 check*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*) adj3 (education or educate or educating or information or literature or leaflet* or booklet* or pamphlet* or website* or knowledge)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/87–97</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49 and 86 and 98</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">100.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49 and (73 or 77 or 81)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62 or 99 or 100</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab3"><div id="ch1.appb.tab3" class="table"><h3><span class="title">Embase (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab3_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Palliative therapy/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Terminal care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Hospice care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Terminally ill patient/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 (care* or caring or ill*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Nursing home/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Respite Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Hospice/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Doctor patient relation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Long term care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Health care delivery/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–26</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/28–32</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33 not 34</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/35–42</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27 not 43</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44 not 45</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 46 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(commission* adj2 (support* or service* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((service* or program* or co-ordinat* or co ordinat* or coordinat*) adj2 (model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Clinical Pathway/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((critical or clinic* or service* or care) adj2 path*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Care Bundle/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(care adj2 (bundle* or service* or package* or standard*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/48–53</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(assess* or criteria* or predict* or recogni* or identif* or refer*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47 and 54 and 55</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">gold standard*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47 and 57</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(amber adj2 bundle).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56 or 58 or 59</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">interdisciplinary communication/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">patient care team*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((interdisciplin* or inter-disciplin* or interprofession* or inter-profession* or multidisciplin* or multi-disciplin* or multi-profession* or multiprofession* or transprofession* or trans-profession*) adj2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((integrat* or network*) adj2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(key adj2 work*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) adj2 (lead or leader or leads or facilitat*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) adj1 profession*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Case Management/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(case adj2 manage*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(co-ordinator* or coordinator* or coordinate* or co-ordinate*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/61–70</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp patient referral/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(referral* or referred or referring or refer or refers or consult*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(recommend* or direct*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/72–74</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76 or 77</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Caregiver/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Spouse/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Family/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/79–82</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((replacement or break* or holiday* or respite) adj3 (care* or service*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((communit* or support* or psychosocial* or psycholog*) adj3 (service* or group* or system*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((group* or support* or psychosocial* or psycholog*) adj3 (selfhelp or self help or therap*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((psychosocial* or psycholog*) adj2 support*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Self-Help/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Social support/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Counseling/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(counseling or counselling*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(buddy* or buddies).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((health* or medical*) adj2 check*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*) adj3 (education or educate or educating or information or literature or leaflet* or booklet* or pamphlet* or website* or knowledge)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/84–94</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47 and 83 and 95</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47 and (71 or 75 or 78)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60 or 96 and 97</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab4"><div id="ch1.appb.tab4" class="table"><h3><span class="title">Cochrane Library (Wiley) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab4_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Palliative Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Terminal Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Hospice Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Terminally Ill] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) near/2 (care* or caring or ill*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) near (phase* or stage*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Nursing Homes] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) near/2 (home or homes)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Respite Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) near/2 (care or caring)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Hospices] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Care Planning] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Continuity of Patient Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) near/3 (care or caring) near/3 (continu* or plan*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Attitude to Death] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* near/3 (death* or dying*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Physician-Patient Relations] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Long-Term Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Delivery of Health Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end near/2 life):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) near/2 (year or month*) near/2 life):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) near/2 (patient* or person* or people or care or caring)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #1–#26)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(commission* near/2 (support* or service* or model*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((service* or program* or co-ordinat* or co ordinat* or coordinat*) near/2 (model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Critical Pathways] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((critical or clinic* or service* or care) near/2 path*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Care Bundles] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(care near/2 (bundle* or service* or package* or standard*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #28–#33)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(assess* or criteria* or predict* or recogni* or identif* or refer*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27 and #34 and #35</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">gold standard*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27 and #37</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(amber near/2 bundle):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#36 or #38 or #39</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Care Team] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Interdisciplinary Communication] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((interdisciplin* or inter-disciplin* or interprofession* or inter-profession* or multidisciplin* or multi-disciplin* or multi-profession* or multiprofession* or transprofession* or trans-profession*) near/2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((integrat* or network*) near/2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(key near/2 work*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) near/2 (lead or leader or leads or facilitat*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) near/1 profession*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Case Management] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(case near/2 manage*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(co-ordinator* or coordinator* or coordinate* or co-ordinate*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #41–#50)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Referral and Consultation] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(referral* or referred or referring or refer or refers or consult*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(recommend* or direct*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #52–#53)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Advance Care Planning] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* near/2 (plan* or decision* or directive*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #56–#58)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Caregivers] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Spouses] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Family] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #60–#63)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((replacement or break* or holiday* or respite) near/3 (care* or service*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((communit* or support* or psychosocial* or psycholog*) near/3 (service* or group* or system*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((group* or support* or psychosocial* or psycholog*) near/3 (selfhelp or self help or therap*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((psychosocial* or psycholog*) near/2 support*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Self-Help Groups] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Social Support] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Counseling] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(counseling or counselling*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(buddy* or buddies):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health or medical*) near/3 check*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*) near/3 (education or educate or educating or information or literature or leaflet* or booklet* or pamphlet* or website* or knowledge):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #65–#75)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27 and #64 and #76</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27 and (#51 or #55 or #59)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#40 or #77 or #78</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab5"><div id="ch1.appb.tab5" class="table"><h3><span class="title">CINAHL (EBSCO) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab5_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Palliative care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Terminal care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Hospice care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI palliat* OR AB palliat*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MW Terminally ill</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( terminal* or long term or longterm ) AND TI ( care* or caring or ill* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( terminal* or long term or longterm ) AND AB ( care* or caring or ill* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( dying or terminal ) AND TI ( phase* or stage* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( dying or terminal ) AND AB ( phase* or stage* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI life limit* OR AB life limit*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Nursing homes</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( care or nursing ) AND TI ( home or homes )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( care or nursing ) AND AB ( home or homes )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Respite care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( respite or day ) AND TI ( care or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( respite or day ) AND AB ( care or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Hospices</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI Hospice* OR AB Hospice*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Patient Care Plans”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Attitude to Death</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI attitude* AND TI ( death* or dying )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB attitude* AND AB ( death* or dying )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Physician-Patient Relations</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Long Term Care”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Health Care Delivery”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI end AND TI life OR AB end AND AB life</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI EOLC OR AB EOLC</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( last or final ) AND TI ( year or month ) AND TI life</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( last or final ) AND AB ( year or month ) AND AB life</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( dying or death ) AND TI ( patient* or person* or people or care or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( dying or death ) AND AB ( patient* or person* or people or care or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI advance* AND TI ( plan* or decision* or directive* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB advance* AND AB ( plan* or decision* or directive* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI commission* AND TI ( (support* or service* or model*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB commission* AND AB ( (support* or service* or model*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( service* or program* or co-ordinat* or co ordinat* or coordinat* ) AND TI ( model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( service* or program* or co-ordinat* or co ordinat* or coordinat* ) AND AB ( model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( critical or clinic* or service* or care ) AND TI path*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( critical or clinic* or service* or care ) AND AB path*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI care AND TI ( bundle* or service* or package* or standard* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB care AND AB ( bundle* or service* or package* or standard* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( assess* or criteria* or predict* or recogni* or identif* or refer* ) OR AB ( assess* or criteria* or predict* or recogni* or identif* or refer* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S34 AND S43 AND S44</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI gold standard* OR AB gold standard*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S34 AND S46</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI amber AND TI bundle</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB amber AND AB bundle</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S48 OR S49</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S45 OR S47 OR S50</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Multidisciplinary Care Team+”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MDT OR IDT</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((interdisciplin* or inter-disciplin* or interprofession* or inter-profession* or multidisciplin* or multi-disciplin* or multi-profession* or multiprofession* or transprofession* or trans-profession*) n2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((integrat* or network*) n2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI (key n2 work*) OR AB (key n2 work*)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( ((healthcare or care) n2 (lead or leader or leads or facilitat*)) ) OR AB ( ((healthcare or care) n2 (lead or leader or leads or facilitat*)) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( ((healthcare or care) n1 profession*) ) OR AB ( ((healthcare or care) n1 profession*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Case Management</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI (case n2 manage*) OR AB (case n2 manage*)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( (co-ordinator* or coordinator* or coordinate* or co-ordinate*)*) ) OR AB ( (coordinator* or coordinator* or coordinate* or co-ordinate*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S52 OR S53 OR S54 OR S55 OR S56 OR S57 OR S58 OR S59 OR S60 OR S61</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Referral and Consultation+”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( referral* or referred or referring or refer or refers or consult* ) OR AB ( referral* or referred or referring or refer or refers or consult* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( recommend* or direct* ) OR AB ( recommend* or direct* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S63 OR S64 OR S65</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI advance* AND TI ( plan* or decision* or directive* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB advance* AND AB ( plan* or decision* or directive* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S67 OR S68</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S34 AND (S62 OR S66 OR S69)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S51 or S70</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab6"><div id="ch1.appb.tab6" class="table"><h3><span class="title">PsycINFO (ProQuest) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab6_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ti,ab(commission* NEAR/2 (support* OR service* OR model*)) OR ((service* OR program* OR co-ordinat* OR coordinat*) NEAR/2 (model* OR deliver* OR strateg* OR support* OR access* OR method* OR system* OR policies OR policy OR availab*))) AND (SU.EXACT(“Palliative Care”) OR SU.EXACT(“Terminally Ill Patients”) OR SU.EXACT(“Hospice”) OR ti,ab(palliat*) OR ti,ab((terminal* OR long-term OR longterm) NEAR/2 (care* OR caring OR ill*)) OR ti,ab((dying OR terminal) NEAR/1 (phase* OR stage*)) OR ti,ab(life-limit*) OR SU.EXACT(“Nursing Homes”) OR ti,ab((care OR nursing) NEAR/2 (home OR homes)) OR SU.EXACT(“Respite Care”) OR ti,ab((respite OR day) NEAR/2 (care OR caring)) OR ti,ab(hospice*) OR MJSUB.EXACT(“Treatment Planning”) OR MJSUB.EXACT(“Continuum of Care”) OR ti,ab((advance* OR patient*) NEAR/3 (care OR caring) NEAR/3 (continu* OR plan*)) OR MJSUB.EXACT(“Long Term Care”) OR ti,ab(attitude* NEAR/3 (death* OR dying*)) OR ti,ab(end NEAR/2 life) OR ti,ab(EOLC) OR ti,ab((last OR final) NEAR/2 (year OR month*) NEAR/2 life) OR ti,ab((dying OR death) NEAR/2 (patient* OR person* OR people OR care OR caring)))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adolescence (13–17 Yrs), Adulthood (18 Yrs & Older), Aged (65 Yrs & Older), Middle Age (40–64 Yrs), Thirties (30–39 Yrs), Very Old (85 Yrs & Older), Young Adulthood (1829 Yrs)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 and 2</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Conference Proceedings, Journal Article, Peer Reviewed Journal</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 and 4</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab7"><div id="ch1.appb.tab7" class="table"><h3><span class="title">HMIC (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab7_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp End of life care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(terminal* adj ill*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–8</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp Paediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp older people/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 not 10</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 11 to English</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 12 to (audiovis or book or chapter dh helmis or circular or microfiche dh helmis or multimedias or website)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 12 to (audiocass or books or cdrom or chapter or dept pubs or diskettes or folio pamp or “map” or marc or microfiche or multimedia or pamphlet or parly or press or press rel or thesis or trustdoc or video or videos or website)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 or 14</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12 not 15</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">euthanasia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">euthanasia.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17 or 18</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 not 19</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab8"><div id="ch1.appb.tab8" class="table"><h3><span class="title">SPP (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab8_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nursing adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(terminal* adj2 ill*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(respite adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–15</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(child* or infant*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(adult* or adolescent*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17 not 18</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 not 19</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 20 to (journal or journal article or online resource or online report or report)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab9"><div id="ch1.appb.tab9" class="table"><h3><span class="title">ASSIA (ProQuest) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab9/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab9_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab. ((ti,ab(commission* N/2 (support* or service* or model*)) OR ti,ab((service* or program* or co-ordinat* or coordinat*) N/2 (model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab*))) AND ((SU.EXACT(“Care” OR “Clinical nursing” OR “Community homes” OR “Community nursery nursing” OR “Community nursing” OR “Compassionate care” OR “Continuing care” OR “District nursing” OR “Family centred care” OR “Geriatric wards” OR “Group care” OR “Health visiting” OR “Home care” OR “Home from home care” OR “Home health aides” OR “Home helps” OR “Hospices” OR “Hostel wards” OR “Informal care” OR “Integrated care pathways” OR “Intentional care” OR “Intermediate care” OR “Intermediate care centres” OR “Lack of care” OR “Learning disability nursing” OR “Length of stay” OR “Liaison nursing” OR “Long stay wards” OR “Long term care” OR “Long term home care” OR “Long term residential care” OR “Nurse led care” OR “Nursing” OR “Occupational health nursing” OR “Ontological care” OR “Out of home care” OR “Outreach nursing” OR “Palliative care” OR “Paranursing” OR “Pastoral care” OR “Patient care” OR “Primary nursing” OR “Private residential care” OR “Process centred care” OR “Quality of care” OR “Radical health visiting” OR “Residential care” OR “Residential group care” OR “Respite care” OR “Shared care” OR “Social care” “Temporary care” OR “Terminal care” OR “Wards”) OR (SU.EXACT(“Terminally ill elderly people”) OR SU.EXACT(“Terminally ill fathers”) OR SU.EXACT(“Terminally ill elderly men”) OR SU.EXACT(“Terminally ill elderly women”) OR SU.EXACT(“Terminally ill young adults”) OR SU.EXACT(“Terminally ill parents”) OR SU.EXACT(“Terminally ill women”) OR SU.EXACT(“Terminally ill widowed sisters”) OR SU.EXACT(“Terminally ill colleagues”) OR SU.EXACT(“Terminally ill young girls”) OR SU.EXACT(“Terminally ill people”) OR SU.EXACT(“Terminally ill men”)) OR SU.EXACT(“Advance directives” OR “Do not resuscitate orders” OR “Durable power of attorney for health care” OR “Living wills” OR “Treatment preferences” OR “Treatment needs”)) OR (ti,ab((advance* or patient*) N/3 (care or caring) N/3 (continu* or plan*)) or ti,ab(attitude* N/3 (death* or dying*)) or ti,ab(end N/2 life) or ti,ab(EOLC) or ti,ab((last or final) N/2 (year or month*) N/2 life) or ti,ab((dying or death) N/2 (patient* or person* or people or care or caring))))) OR SU.EXACT(“End of life decisions”)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab10"><div id="ch1.appb.tab10" class="table"><h3><span class="label">Table 7</span><span class="title">Database date parameters and filters used</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab10/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab10_lrgtbl__"><table><thead><tr><th id="hd_h_ch1.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Database</th><th id="hd_h_ch1.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dates searched</th><th id="hd_h_ch1.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Search filter used</th></tr></thead><tbody><tr><td headers="hd_h_ch1.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medline</td><td headers="hd_h_ch1.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2014 – 04 January 2019</td><td headers="hd_h_ch1.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Exclusions</p>
|
|
<p>Health economics studies</p>
|
|
<p>Health economics modelling studies</p>
|
|
<p>Quality of life studies</p>
|
|
</td></tr><tr><td headers="hd_h_ch1.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase</td><td headers="hd_h_ch1.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2014 – 04 January 2019</td><td headers="hd_h_ch1.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Exclusions</p>
|
|
<p>Health economics studies</p>
|
|
<p>Health economics modelling studies</p>
|
|
<p>Quality of life studies</p>
|
|
</td></tr><tr><td headers="hd_h_ch1.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Centre for Research and Dissemination (CRD)</td><td headers="hd_h_ch1.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>HTA - Inception – 04 January 2019</p>
|
|
<p>NHSEED - Inception to March 2015</p>
|
|
</td><td headers="hd_h_ch1.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab11"><div id="ch1.appb.tab11" class="table"><h3><span class="title">Medline (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab11/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab11_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Palliative care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Terminal care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospice care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Terminally Ill/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 (care* or caring or ill*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nursing Homes/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Respite Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospices/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Advance Care Planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Continuity of Patient Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Physician-Patient Relations/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Long-Term Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Delivery of Health Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–29</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">news/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp historical article/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">comment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/31–38</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39 not 40</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animals, Laboratory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experimentation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Models, Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/41–47</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30 not 48</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 49 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50 not 51</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">economics/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">value of life/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp “costs and cost analysis”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Economics, Hospital/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Economics, medical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Economics, nursing/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">economics, pharmaceutical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp “Fees and Charges”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp budgets/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cost*.ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(economic* or pharmaco?economic*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(price* or pricing*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(cost* adj2 (effectiv* or utilit* or benefit* or minimi* or unit* or estimat* or variable*)).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(financ* or fee or fees).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(value adj2 (money or monetary)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/53–68</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp models, economic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Models, Theoretical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Models, Organizational/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">markov chains/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">monte carlo method/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Decision Theory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(markov* or monte carlo).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">econom* model*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(decision* adj2 (tree* or analy* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/70–78</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">quality-adjusted life years/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(quality adj2 (wellbeing or well being)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">disability adjusted life.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qal* or qtime* or qwb* or daly*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(euroqol* or eq5d* or eq 5*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qol* or hql* or hqol* or h qol* or hrqol* or hr qol*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health utility* or utility score* or disutilit* or utility value*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hui or hui1 or hui2 or hui3).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health* year* equivalent* or hye or hyes).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">discrete choice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">rosser.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(willingness to pay or time tradeoff or time trade off or tto or standard gamble*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf36* or sf 36* or short form 36* or shortform 36* or shortform36*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf20 or sf 20 or short form 20 or shortform 20 or shortform20).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf12* or sf 12* or short form 12* or shortform 12* or shortform12*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf8* or sf 8* or short form 8* or shortform 8* or shortform8*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf6* or sf 6* or short form 6* or shortform 6* or shortform6*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/80–98</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">100.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52 and (69 or 79 or 99)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab12"><div id="ch1.appb.tab12" class="table"><h3><span class="title">Embase (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab12/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab12_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Palliative therapy/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Terminal care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Hospice care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Terminally ill patient/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 (care* or caring or ill*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Nursing home/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Respite Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Hospice/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Doctor patient relation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Long term care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Health care delivery/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–28</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/30–34</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35 not 36</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/37–44</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29 not 45</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 46 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47 not 48</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">health economics/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp economic evaluation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp health care cost/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp fee/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">funding/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cost*.ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(economic* or pharmaco?economic*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(price* or pricing*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(cost* adj2 (effectiv* or utilit* or benefit* or minimi* or unit* or estimat* or variable*)).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(financ* or fee or fees).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(value adj2 (money or monetary)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/50–62</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">statistical model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp economic aspect/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64 and 65</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*theoretical model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*nonbiological model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">stochastic model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">decision theory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">decision tree/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">monte carlo method/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(markov* or monte carlo).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">econom* model*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(decision* adj2 (tree* or analy* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/66–75</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">quality-adjusted life years/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“quality of life index”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">short form 12/ or short form 20/ or short form 36/ or short form 8/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(quality adj2 (wellbeing or well being)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">disability adjusted life.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qal* or qtime* or qwb* or daly*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(euroqol* or eq5d* or eq 5*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qol* or hql* or hqol* or h qol* or hrqol* or hr qol*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health utility* or utility score* or disutilit* or utility value*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hui or hui1 or hui2 or hui3).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health* year* equivalent* or hye or hyes).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">discrete choice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">rosser.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(willingness to pay or time tradeoff or time trade off or tto or standard gamble*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf36* or sf 36* or short form 36* or shortform 36* or shortform36*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf20 or sf 20 or short form 20 or shortform 20 or shortform20).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf12* or sf 12* or short form 12* or shortform 12* or shortform12*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf8* or sf 8* or short form 8* or shortform 8* or shortform8*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf6* or sf 6* or short form 6* or shortform 6* or shortform6*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/77–97</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49 and (63 or 76 or 98)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch1appbtab13"><div id="ch1.appb.tab13" class="table"><h3><span class="title">NHS EED and HTA (CRD) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appb.tab13/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appb.tab13_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Palliative Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Terminal Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Hospice Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(palliat*) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Terminally Ill IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((terminal* or long term or longterm) adj2 (care* or caring or ill*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((dying or terminal) adj (phase* or stage*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(life limit*) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Nursing Homes IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((care or nursing) adj2 (home or homes))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Respite Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((respite or day) adj2 (care or caring))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Hospices IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospice*) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Advance Care Planning EXPLODE ALL TREES IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* adj2 (plan* or decision* or directive*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(living will*) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Patient Care Planning IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Continuity of Patient Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Attitude to Death IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attitude* adj3 (death* or dying*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Physician-Patient Relations IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Long-Term Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Delivery of Health Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((end adj2 life)) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(EOLC) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((last or final) adj2 (year or month*) adj2 life)) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((dying or death) adj2 (patient* or person* or people or care or caring))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(#30) IN NHSEED</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(#30) IN HTA</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch1appcfig1"><div id="ch1.appc.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20Flow%20chart%20of%20clinical%20study%20selection%20for%20the%20review%20of%20what%20are%20the%20best%20service%20models%20to%20support%20the%20identification%20of%20people%20who%20may%20be%20entering%20the%20last%20year%20of%20life%3F&p=BOOKS&id=558773_ch1appcf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558773/bin/ch1appcf1.jpg" alt="Figure 1. Flow chart of clinical study selection for the review of what are the best service models to support the identification of people who may be entering the last year of life?" class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">Flow chart of clinical study selection for the review of what are the best service models to support the identification of people who may be entering the last year of life?</span></h3></div></article><article data-type="fig" id="figobch1appcfig2"><div id="ch1.appc.fig2" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%202.%20Flow%20chart%20of%20health%20economic%20study%20selection%20for%20the%20guideline.&p=BOOKS&id=558773_ch1appcf2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558773/bin/ch1appcf2.jpg" alt="Figure 2. Flow chart of health economic study selection for the guideline." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 2</span><span class="title">Flow chart of health economic study selection for the guideline</span></h3><div class="caption"><p>* Non-relevant population, intervention, comparison, design or setting; non-English language</p></div></div></article><article data-type="fig" id="figobch1appefig3"><div id="ch1.appe.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%203.%20Proactive%20case-finding%20versus%20no%20intervention%20in%20end%20of%20life%20care%3A%20length%20of%20stay%20in%20hospital%20(days).&p=BOOKS&id=558773_ch1appef3.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558773/bin/ch1appef3.jpg" alt="Figure 3. Proactive case-finding versus no intervention in end of life care: length of stay in hospital (days)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 3</span><span class="title">Proactive case-finding versus no intervention in end of life care: length of stay in hospital (days)</span></h3></div></article><article data-type="fig" id="figobch1appefig4"><div id="ch1.appe.fig4" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%204.%20Proactive%20case-finding%20versus%20no%20intervention%20in%20end%20of%20life%20care%3A%20length%20of%20MICU%20stay%20(days).&p=BOOKS&id=558773_ch1appef4.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558773/bin/ch1appef4.jpg" alt="Figure 4. Proactive case-finding versus no intervention in end of life care: length of MICU stay (days)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 4</span><span class="title">Proactive case-finding versus no intervention in end of life care: length of MICU stay (days)</span></h3></div></article><article data-type="fig" id="figobch1appefig5"><div id="ch1.appe.fig5" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%205.%20Proactive%20case-finding%20versus%20no%20intervention%20in%20end%20of%20life%20care%3A%20discharge%20to%20another%20hospital.&p=BOOKS&id=558773_ch1appef5.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558773/bin/ch1appef5.jpg" alt="Figure 5. Proactive case-finding versus no intervention in end of life care: discharge to another hospital." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 5</span><span class="title">Proactive case-finding versus no intervention in end of life care: discharge to another hospital</span></h3></div></article><article data-type="table-wrap" id="figobch1appftab1"><div id="ch1.appf.tab1" class="table"><h3><span class="label">Table 8</span><span class="title">Clinical evidence profile: Proactive case-finding versus no intervention</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appf.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appf.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch1.appf.tab1_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch1.appf.tab1_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch1.appf.tab1_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch1.appf.tab1_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch1.appf.tab1_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch1.appf.tab1_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch1.appf.tab1_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch1.appf.tab1_1_1_1_1" id="hd_h_ch1.appf.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch1.appf.tab1_1_1_1_1" id="hd_h_ch1.appf.tab1_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch1.appf.tab1_1_1_1_1" id="hd_h_ch1.appf.tab1_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch1.appf.tab1_1_1_1_1" id="hd_h_ch1.appf.tab1_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch1.appf.tab1_1_1_1_1" id="hd_h_ch1.appf.tab1_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch1.appf.tab1_1_1_1_1" id="hd_h_ch1.appf.tab1_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch1.appf.tab1_1_1_1_1" id="hd_h_ch1.appf.tab1_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch1.appf.tab1_1_1_1_2" id="hd_h_ch1.appf.tab1_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Proactive case-finding</th><th headers="hd_h_ch1.appf.tab1_1_1_1_2" id="hd_h_ch1.appf.tab1_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No intervention</th><th headers="hd_h_ch1.appf.tab1_1_1_1_3" id="hd_h_ch1.appf.tab1_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch1.appf.tab1_1_1_1_3" id="hd_h_ch1.appf.tab1_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_1 hd_h_ch1.appf.tab1_1_1_2_2 hd_h_ch1.appf.tab1_1_1_2_3 hd_h_ch1.appf.tab1_1_1_2_4 hd_h_ch1.appf.tab1_1_1_2_5 hd_h_ch1.appf.tab1_1_1_2_6 hd_h_ch1.appf.tab1_1_1_2_7 hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_8 hd_h_ch1.appf.tab1_1_1_2_9 hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_10 hd_h_ch1.appf.tab1_1_1_2_11 hd_h_ch1.appf.tab1_1_1_1_4 hd_h_ch1.appf.tab1_1_1_1_5" id="hd_b_ch1.appf.tab1_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:bottom;">Length of stay (days) (Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_1 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_2 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_3 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>a</sup></td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_4 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_5 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_6 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_7 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_8 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26</td><td headers="hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_9 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26</td><td headers="hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_10 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_11 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 4.7 lower (8.87 to 0.53 lower)</td><td headers="hd_h_ch1.appf.tab1_1_1_1_4 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch1.appf.tab1_1_1_1_5 hd_b_ch1.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_1 hd_h_ch1.appf.tab1_1_1_2_2 hd_h_ch1.appf.tab1_1_1_2_3 hd_h_ch1.appf.tab1_1_1_2_4 hd_h_ch1.appf.tab1_1_1_2_5 hd_h_ch1.appf.tab1_1_1_2_6 hd_h_ch1.appf.tab1_1_1_2_7 hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_8 hd_h_ch1.appf.tab1_1_1_2_9 hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_10 hd_h_ch1.appf.tab1_1_1_2_11 hd_h_ch1.appf.tab1_1_1_1_4 hd_h_ch1.appf.tab1_1_1_1_5" id="hd_b_ch1.appf.tab1_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Length of stay in MICU (days) (Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_1 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_2 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_3 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>a</sup></td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_4 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_5 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_6 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_7 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_8 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26</td><td headers="hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_9 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">26</td><td headers="hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_10 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_11 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 3.3 lower (5.46 to 1.14 lower)</td><td headers="hd_h_ch1.appf.tab1_1_1_1_4 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_ch1.appf.tab1_1_1_1_5 hd_b_ch1.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_1 hd_h_ch1.appf.tab1_1_1_2_2 hd_h_ch1.appf.tab1_1_1_2_3 hd_h_ch1.appf.tab1_1_1_2_4 hd_h_ch1.appf.tab1_1_1_2_5 hd_h_ch1.appf.tab1_1_1_2_6 hd_h_ch1.appf.tab1_1_1_2_7 hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_8 hd_h_ch1.appf.tab1_1_1_2_9 hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_10 hd_h_ch1.appf.tab1_1_1_2_11 hd_h_ch1.appf.tab1_1_1_1_4 hd_h_ch1.appf.tab1_1_1_1_5" id="hd_b_ch1.appf.tab1_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Discharged to another hospital</th></tr><tr><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_1 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_2 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_3 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>a</sup></td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_4 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_5 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_6 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>b</sup></td><td headers="hd_h_ch1.appf.tab1_1_1_1_1 hd_h_ch1.appf.tab1_1_1_2_7 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_8 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1/26 (3.8%)</td><td headers="hd_h_ch1.appf.tab1_1_1_1_2 hd_h_ch1.appf.tab1_1_1_2_9 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">0%</td><td headers="hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_10 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Peto OR (7.39 (0.15 to 372.38)</td><td headers="hd_h_ch1.appf.tab1_1_1_1_3 hd_h_ch1.appf.tab1_1_1_2_11 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40 higher (60 lower to 140 higher)</td><td headers="hd_h_ch1.appf.tab1_1_1_1_4 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch1.appf.tab1_1_1_1_5 hd_b_ch1.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch1.appf.tab1_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch1.appf.tab1_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch1appgtab1"><div id="ch1.appg.tab1" class="table"><h3><span class="label">Table 9</span><span class="title">Studies excluded from the clinical review</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558773/table/ch1.appg.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch1.appg.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reference</th><th id="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reason for exclusion</th></tr></thead><tbody><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adelson 2017<a class="bibr" href="#ch1.ref1" rid="ch1.ref1"><sup>1</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ahmed 2015<a class="bibr" href="#ch1.ref2" rid="ch1.ref2"><sup>2</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Amass 2006<a class="bibr" href="#ch1.ref3" rid="ch1.ref3"><sup>3</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Amblas-Novellas 2016<a class="bibr" href="#ch1.ref4" rid="ch1.ref4"><sup>4</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Amro 2016<a class="bibr" href="#ch1.ref5" rid="ch1.ref5"><sup>5</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Autor 2013<a class="bibr" href="#ch1.ref6" rid="ch1.ref6"><sup>6</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Baba 2015<a class="bibr" href="#ch1.ref7" rid="ch1.ref7"><sup>7</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Beernaert 2014<a class="bibr" href="#ch1.ref8" rid="ch1.ref8"><sup>8</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Begum 2013<a class="bibr" href="#ch1.ref9" rid="ch1.ref9"><sup>9</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bennett 2000<a class="bibr" href="#ch1.ref10" rid="ch1.ref10"><sup>10</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Boyd 2010<a class="bibr" href="#ch1.ref11" rid="ch1.ref11"><sup>11</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Broom 2012<a class="bibr" href="#ch1.ref12" rid="ch1.ref12"><sup>12</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Carduff 2016<a class="bibr" href="#ch1.ref14" rid="ch1.ref14"><sup>14</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Carey 2015<a class="bibr" href="#ch1.ref15" rid="ch1.ref15"><sup>15</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Chan 2012<a class="bibr" href="#ch1.ref16" rid="ch1.ref16"><sup>16</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Chang 2015<a class="bibr" href="#ch1.ref17" rid="ch1.ref17"><sup>17</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Chen 2017<a class="bibr" href="#ch1.ref18" rid="ch1.ref18"><sup>18</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Clark 2016<a class="bibr" href="#ch1.ref19" rid="ch1.ref19"><sup>19</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Clarkson 2013<a class="bibr" href="#ch1.ref20" rid="ch1.ref20"><sup>20</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cotogni 2017<a class="bibr" href="#ch1.ref21" rid="ch1.ref21"><sup>21</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dalgaard 2010<a class="bibr" href="#ch1.ref22" rid="ch1.ref22"><sup>22</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Davis 2015<a class="bibr" href="#ch1.ref23" rid="ch1.ref23"><sup>23</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dhiliwal 2016<a class="bibr" href="#ch1.ref24" rid="ch1.ref24"><sup>24</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Downar 2017<a class="bibr" href="#ch1.ref25" rid="ch1.ref25"><sup>25</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Evans 2016<a class="bibr" href="#ch1.ref26" rid="ch1.ref26"><sup>26</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fenning 2012<a class="bibr" href="#ch1.ref27" rid="ch1.ref27"><sup>27</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Feyi 2015<a class="bibr" href="#ch1.ref28" rid="ch1.ref28"><sup>28</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fromme 2010<a class="bibr" href="#ch1.ref29" rid="ch1.ref29"><sup>29</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Glajchen 2011<a class="bibr" href="#ch1.ref30" rid="ch1.ref30"><sup>30</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Glare 2001<a class="bibr" href="#ch1.ref31" rid="ch1.ref31"><sup>31</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Goodlin 2004<a class="bibr" href="#ch1.ref32" rid="ch1.ref32"><sup>32</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Grbich 2005<a class="bibr" href="#ch1.ref33" rid="ch1.ref33"><sup>33</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Greiner 2003<a class="bibr" href="#ch1.ref34" rid="ch1.ref34"><sup>34</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Unable to locate</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gwilliam 2013<a class="bibr" href="#ch1.ref35" rid="ch1.ref35"><sup>35</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Haga 2012<a class="bibr" href="#ch1.ref36" rid="ch1.ref36"><sup>36</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hamano 2015<a class="bibr" href="#ch1.ref37" rid="ch1.ref37"><sup>37</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Harrison 2012<a class="bibr" href="#ch1.ref38" rid="ch1.ref38"><sup>38</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Haydar 2017<a class="bibr" href="#ch1.ref39" rid="ch1.ref39"><sup>39</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not review population</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hornbrook 2013<a class="bibr" href="#ch1.ref40" rid="ch1.ref40"><sup>40</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hosie 2014<a class="bibr" href="#ch1.ref41" rid="ch1.ref41"><sup>41</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hui 2016<a class="bibr" href="#ch1.ref42" rid="ch1.ref42"><sup>42</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Iwashyna 2001<a class="bibr" href="#ch1.ref43" rid="ch1.ref43"><sup>43</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Unable to locate</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Janssen 2012<a class="bibr" href="#ch1.ref44" rid="ch1.ref44"><sup>44</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Jenko 2015<a class="bibr" href="#ch1.ref45" rid="ch1.ref45"><sup>45</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Johnson 2012<a class="bibr" href="#ch1.ref47" rid="ch1.ref47"><sup>47</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Johnston 1998<a class="bibr" href="#ch1.ref48" rid="ch1.ref48"><sup>48</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kennedy 2014<a class="bibr" href="#ch1.ref49" rid="ch1.ref49"><sup>49</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate population</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kristjanson 2005<a class="bibr" href="#ch1.ref50" rid="ch1.ref50"><sup>50</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kuhn 2012<a class="bibr" href="#ch1.ref51" rid="ch1.ref51"><sup>51</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ledoux 2015<a class="bibr" href="#ch1.ref52" rid="ch1.ref52"><sup>52</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not relevant to PICO</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Leysen 2015<a class="bibr" href="#ch1.ref53" rid="ch1.ref53"><sup>53</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Llobera 2000<a class="bibr" href="#ch1.ref54" rid="ch1.ref54"><sup>54</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lynn 2000<a class="bibr" href="#ch1.ref55" rid="ch1.ref55"><sup>55</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Maquire 2013<a class="bibr" href="#ch1.ref57" rid="ch1.ref57"><sup>57</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Marcucci 2016<a class="bibr" href="#ch1.ref58" rid="ch1.ref58"><sup>58</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mason 2015<a class="bibr" href="#ch1.ref59" rid="ch1.ref59"><sup>59</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meffert 2016<a class="bibr" href="#ch1.ref60" rid="ch1.ref60"><sup>60</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention and comparison</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mierendorf 2014<a class="bibr" href="#ch1.ref61" rid="ch1.ref61"><sup>61</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Milnes 2015<a class="bibr" href="#ch1.ref62" rid="ch1.ref62"><sup>62</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mittman 2018{Mittmann, 2018 #3553}</td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Conference abstract</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moretti 2016<a class="bibr" href="#ch1.ref64" rid="ch1.ref64"><sup>64</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moretti 2016<a class="bibr" href="#ch1.ref63" rid="ch1.ref63"><sup>63</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Unable to locate</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Morita 2008<a class="bibr" href="#ch1.ref65" rid="ch1.ref65"><sup>65</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Norton 2007<a class="bibr" href="#ch1.ref68" rid="ch1.ref68"><sup>68</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not relevant to PICO</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">O’Callaghan 2014<a class="bibr" href="#ch1.ref69" rid="ch1.ref69"><sup>69</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">O’Mahony 2005<a class="bibr" href="#ch1.ref70" rid="ch1.ref70"><sup>70</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Philip 2010<a class="bibr" href="#ch1.ref71" rid="ch1.ref71"><sup>71</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate interventions</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Phua 2016<a class="bibr" href="#ch1.ref72" rid="ch1.ref72"><sup>72</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design (abstract)</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rainone 2007<a class="bibr" href="#ch1.ref74" rid="ch1.ref74"><sup>74</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reynolds 2010<a class="bibr" href="#ch1.ref46" rid="ch1.ref46"><sup>46</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Riggs 2016<a class="bibr" href="#ch1.ref75" rid="ch1.ref75"><sup>75</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rocque 2015<a class="bibr" href="#ch1.ref76" rid="ch1.ref76"><sup>76</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rojas 2016<a class="bibr" href="#ch1.ref77" rid="ch1.ref77"><sup>77</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schenker 2014<a class="bibr" href="#ch1.ref78" rid="ch1.ref78"><sup>78</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schofield 2006<a class="bibr" href="#ch1.ref79" rid="ch1.ref79"><sup>79</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not relevant to PICO</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Seow 2009<a class="bibr" href="#ch1.ref80" rid="ch1.ref80"><sup>80</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sharpe 2016<a class="bibr" href="#ch1.ref81" rid="ch1.ref81"><sup>81</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Shaw 2010<a class="bibr" href="#ch1.ref82" rid="ch1.ref82"><sup>82</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Silvester 2014<a class="bibr" href="#ch1.ref83" rid="ch1.ref83"><sup>83</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Slaven 2007<a class="bibr" href="#ch1.ref84" rid="ch1.ref84"><sup>84</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Smith 2016<a class="bibr" href="#ch1.ref86" rid="ch1.ref86"><sup>86</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Smith 2017<a class="bibr" href="#ch1.ref85" rid="ch1.ref85"><sup>85</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Strupp 2015<a class="bibr" href="#ch1.ref87" rid="ch1.ref87"><sup>87</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Szekendi 2017<a class="bibr" href="#ch1.ref88" rid="ch1.ref88"><sup>88</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Takahashi 2012<a class="bibr" href="#ch1.ref89" rid="ch1.ref89"><sup>89</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Thoonsen 2016<a class="bibr" href="#ch1.ref90" rid="ch1.ref90"><sup>90</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trueman 2011<a class="bibr" href="#ch1.ref91" rid="ch1.ref91"><sup>91</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Vanbutsele 2015<a class="bibr" href="#ch1.ref92" rid="ch1.ref92"><sup>92</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Van der Plas 2018{van der Plas, 2018 #3524}</td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study population</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Villa 2015<a class="bibr" href="#ch1.ref93" rid="ch1.ref93"><sup>93</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Vrijmoeth 2016<a class="bibr" href="#ch1.ref94" rid="ch1.ref94"><sup>94</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Waller 2012<a class="bibr" href="#ch1.ref95" rid="ch1.ref95"><sup>95</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Walshe 2008<a class="bibr" href="#ch1.ref96" rid="ch1.ref96"><sup>96</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">White 2016<a class="bibr" href="#ch1.ref98" rid="ch1.ref98"><sup>98</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design and intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">White 2017<a class="bibr" href="#ch1.ref97" rid="ch1.ref97"><sup>97</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Yamada 2017<a class="bibr" href="#ch1.ref99" rid="ch1.ref99"><sup>99</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch1.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Zare 2011<a class="bibr" href="#ch1.ref100" rid="ch1.ref100"><sup>100</sup></a></td><td headers="hd_h_ch1.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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