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class="bkr_bib"><h1 id="_NBK558768_"><span itemprop="name">Evidence review: Timing of referral to palliative care services</span></h1><div class="subtitle">End of life care for adults: service delivery</div><p><b>Evidence review B</b></p><p><i>NICE Guideline, No. 142</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Guideline Centre (UK)</span>.</p><div class="half_rhythm">London: <a href="https://www.nice.org.uk" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2019 Oct</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-3560-4</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2019.</div></div><div class="bkr_clear"></div></div><div id="ch2.s1"><h2 id="_ch2_s1_">1. Early versus late referral to (or provision of) palliative care services</h2><div id="ch2.s1.1"><h3>1.1. Review question: What is the best timing of referral to (or provision of) palliative care services in people thought to be entering their last year of life?</h3></div><div id="ch2.s1.2"><h3>1.2. Introduction</h3><p>Potential benefits from earlier referral to palliative care have been described, at least for people with metastatic cancer, and include better symptom management and longer survival. However, the specification of supportive and palliative care services varies widely, and the elements of care provided to intervention and control groups in studies are not described. The definition of early or late referral also varies. Some people are referred whilst still receiving disease-modifying treatment, others when a decision has been taken to discontinue such treatment. The time period for people to be referred may be between the last 6 months to a year of life, to only a few weeks.</p><p>For diseases or conditions with trajectories that are hard to predict, for example heart failure and COPD, or conditions where recovery from treatment is unlikely but still possible, it is difficult to define the criteria for early or late referral and to compare the effect of one timing against the other. Some conditions, such as some neurological diseases including dementia, may deprive a person of the ability to express their wishes regarding palliative care and, for them, it may be prudent to initiate discussions earlier after diagnosis.</p></div><div id="ch2.s1.3"><h3>1.3. PICO table</h3><p>For full details see the review protocol in <a href="#ch2.appa">Appendix A</a>.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab1"><a href="/books/NBK558768/table/ch2.tab1/?report=objectonly" target="object" title="Table 1" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab1" rid-ob="figobch2tab1"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab1/?report=thumb" src-large="/books/NBK558768/table/ch2.tab1/?report=previmg" alt="Table 1. PICO characteristics of review question." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab1"><a href="/books/NBK558768/table/ch2.tab1/?report=objectonly" target="object" rid-ob="figobch2tab1">Table 1</a></h4><p class="float-caption no_bottom_margin">PICO characteristics of review question. </p></div></div></div><div id="ch2.s1.4"><h3>1.4. Clinical evidence</h3><div id="ch2.s1.4.1"><h4>1.4.1. Included studies</h4><p>A search was conducted for randomised trials and non-randomised comparative studies on the effect of timing of referral to (or provision of) palliative care services in people thought to be entering their last year of life.</p><p>Five studies were included in the review;<a class="bibr" href="#ch2.ref3" rid="ch2.ref3"><sup>3</sup></a>
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<sup>,</sup><a class="bibr" href="#ch2.ref7" rid="ch2.ref7"><sup>7</sup></a>
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<sup>,</sup><a class="bibr" href="#ch2.ref35" rid="ch2.ref35"><sup>35</sup></a>
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<sup>,</sup><a class="bibr" href="#ch2.ref64" rid="ch2.ref64"><sup>64</sup></a>
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<sup>,</sup><a class="bibr" href="#ch2.ref68" rid="ch2.ref68"><sup>68</sup></a> these are summarised below.</p><p>Evidence from these studies is summarised in the clinical evidence summary below (<a class="figpopup" href="/books/NBK558768/table/ch2.tab4/?report=objectonly" target="object" rid-figpopup="figch2tab4" rid-ob="figobch2tab4">Table 4</a>). See also the study selection flow chart in <a href="#ch2.appb">Appendix B</a>, study evidence tables in <a href="#ch2.appd">Appendix D</a>, forest plots in <a href="#ch2.appe">Appendix E</a>, GRADE tables in <a href="#ch2.appf">Appendix F</a> and excluded studies list in <a href="#ch2.appg">Appendix G</a>.</p></div><div id="ch2.s1.4.2"><h4>1.4.2. Summary of clinical studies included in the evidence review</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab2"><a href="/books/NBK558768/table/ch2.tab2/?report=objectonly" target="object" title="Table 2" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab2" rid-ob="figobch2tab2"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab2/?report=thumb" src-large="/books/NBK558768/table/ch2.tab2/?report=previmg" alt="Table 2. Summary of studies included in the evidence review." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab2"><a href="/books/NBK558768/table/ch2.tab2/?report=objectonly" target="object" rid-ob="figobch2tab2">Table 2</a></h4><p class="float-caption no_bottom_margin">Summary of studies included in the evidence review. </p></div></div></div><div id="ch2.s1.4.3"><h4>1.4.3. Quality assessment of clinical studies included in the evidence review</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab3"><a href="/books/NBK558768/table/ch2.tab3/?report=objectonly" target="object" title="Table 3" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab3" rid-ob="figobch2tab3"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab3/?report=thumb" src-large="/books/NBK558768/table/ch2.tab3/?report=previmg" alt="Table 3. Early versus Late Referral: data unsuitable for meta-analysis." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab3"><a href="/books/NBK558768/table/ch2.tab3/?report=objectonly" target="object" rid-ob="figobch2tab3">Table 3</a></h4><p class="float-caption no_bottom_margin">Early versus Late Referral: data unsuitable for meta-analysis. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab4"><a href="/books/NBK558768/table/ch2.tab4/?report=objectonly" target="object" title="Table 4" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab4" rid-ob="figobch2tab4"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab4/?report=thumb" src-large="/books/NBK558768/table/ch2.tab4/?report=previmg" alt="Table 4. Clinical evidence summary: Early (> 3 months between first palliative care consultation and death) versus late (< 3 months between first palliative care consultation and death) referral to palliative care services." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab4"><a href="/books/NBK558768/table/ch2.tab4/?report=objectonly" target="object" rid-ob="figobch2tab4">Table 4</a></h4><p class="float-caption no_bottom_margin">Clinical evidence summary: Early (> 3 months between first palliative care consultation and death) versus late (< 3 months between first palliative care consultation and death) referral to palliative care services. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab5"><a href="/books/NBK558768/table/ch2.tab5/?report=objectonly" target="object" title="Table 5" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab5" rid-ob="figobch2tab5"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab5/?report=thumb" src-large="/books/NBK558768/table/ch2.tab5/?report=previmg" alt="Table 5. Clinical evidence summary: Early (< 30 days between diagnosis and referral) versus late (> 3 months between diagnosis and referral) referral to palliative care services." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab5"><a href="/books/NBK558768/table/ch2.tab5/?report=objectonly" target="object" rid-ob="figobch2tab5">Table 5</a></h4><p class="float-caption no_bottom_margin">Clinical evidence summary: Early (< 30 days between diagnosis and referral) versus late (> 3 months between diagnosis and referral) referral to palliative care services. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab6"><a href="/books/NBK558768/table/ch2.tab6/?report=objectonly" target="object" title="Table 6" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab6" rid-ob="figobch2tab6"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab6/?report=thumb" src-large="/books/NBK558768/table/ch2.tab6/?report=previmg" alt="Table 6. Clinical evidence summary: Early (> 6 months between first palliative care consultation and death) versus late (< 6 months between first palliative care consultation and death) referral to palliative care services." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab6"><a href="/books/NBK558768/table/ch2.tab6/?report=objectonly" target="object" rid-ob="figobch2tab6">Table 6</a></h4><p class="float-caption no_bottom_margin">Clinical evidence summary: Early (> 6 months between first palliative care consultation and death) versus late (< 6 months between first palliative care consultation and death) referral to palliative care services. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab7"><a href="/books/NBK558768/table/ch2.tab7/?report=objectonly" target="object" title="Table 7" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab7" rid-ob="figobch2tab7"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab7/?report=thumb" src-large="/books/NBK558768/table/ch2.tab7/?report=previmg" alt="Table 7. Clinical evidence summary: Early (palliative care provided >30 days before death) versus late (palliative care provided <30 days before death)." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab7"><a href="/books/NBK558768/table/ch2.tab7/?report=objectonly" target="object" rid-ob="figobch2tab7">Table 7</a></h4><p class="float-caption no_bottom_margin">Clinical evidence summary: Early (palliative care provided >30 days before death) versus late (palliative care provided <30 days before death). </p></div></div><p>See <a href="#ch2.appf">Appendix F</a> for full GRADE tables.</p></div></div><div id="ch2.s1.5"><h3>1.5. Economic evidence</h3><div id="ch2.s1.5.1"><h4>1.5.1. Included studies</h4><p>No relevant health economic studies were identified.</p></div><div id="ch2.s1.5.2"><h4>1.5.2. Excluded studies</h4><p>No health economic studies that were relevant to this question were excluded due to assessment of limited applicability or methodological limitations.</p><p>See also the health economic study selection flow chart in <a href="#ch2.appc">Appendix C</a>.</p></div><div id="ch2.s1.5.3"><h4>1.5.3. Unit costs</h4><p><a class="figpopup" href="/books/NBK558768/table/ch2.tab8/?report=objectonly" target="object" rid-figpopup="figch2tab8" rid-ob="figobch2tab8">Table 8</a> and <a class="figpopup" href="/books/NBK558768/table/ch2.tab9/?report=objectonly" target="object" rid-figpopup="figch2tab9" rid-ob="figobch2tab9">Table 9</a> provide some unit costs for specialist and generalist palliative that were presented to the guideline committee to help them consider the cost effectiveness of early versus later referral to palliative care services. <a class="figpopup" href="/books/NBK558768/table/ch2.tab8/?report=objectonly" target="object" rid-figpopup="figch2tab8" rid-ob="figobch2tab8">Table 8</a> provides national average unit costs of specialist palliative care services in hospital and in the community where unit costs were available. <a class="figpopup" href="/books/NBK558768/table/ch2.tab9/?report=objectonly" target="object" rid-figpopup="figch2tab9" rid-ob="figobch2tab9">Table 9</a> provides the unit costs of staff time for people who might provide general palliative care in a hospital and in a community setting. The cost of patient contact as opposed to per working hour has been reported where available. Once a person has been referred to receive palliative care services, the frequency of the services they receive will be very specific to the individual and their circumstances; therefore it was not possible to determine the cost of generalist or specialist palliative care over a specified time interval, for example one week or one month.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab8"><a href="/books/NBK558768/table/ch2.tab8/?report=objectonly" target="object" title="Table 8" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab8" rid-ob="figobch2tab8"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab8/?report=thumb" src-large="/books/NBK558768/table/ch2.tab8/?report=previmg" alt="Table 8. Unit costs for NHS Specialist Palliative Care Services." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab8"><a href="/books/NBK558768/table/ch2.tab8/?report=objectonly" target="object" rid-ob="figobch2tab8">Table 8</a></h4><p class="float-caption no_bottom_margin">Unit costs for NHS Specialist Palliative Care Services. </p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab9"><a href="/books/NBK558768/table/ch2.tab9/?report=objectonly" target="object" title="Table 9" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab9" rid-ob="figobch2tab9"><img class="small-thumb" src="/books/NBK558768/table/ch2.tab9/?report=thumb" src-large="/books/NBK558768/table/ch2.tab9/?report=previmg" alt="Table 9. Unit costs for Generalist Palliative Care Services." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab9"><a href="/books/NBK558768/table/ch2.tab9/?report=objectonly" target="object" rid-ob="figobch2tab9">Table 9</a></h4><p class="float-caption no_bottom_margin">Unit costs for Generalist Palliative Care Services. </p></div></div></div></div><div id="ch2.s1.6"><h3>1.6. Resource costs</h3><p>Recommendations made based on this review (see section <b>Error! Reference source not found.</b>) are not expected to have a substantial impact on resources.</p></div><div id="ch2.s1.7"><h3>1.7. Evidence statements</h3><div id="ch2.s1.7.1"><h4>1.7.1. Clinical evidence statements</h4><div id="ch2.s1.7.1.1"><h5>Early (> 3 months between first palliative care consultation and death) versus late (< 3 months between first palliative care consultation and death) referral to palliative care services</h5><p>Three studies compared referral to palliative care services at > 3 months versus < 3 months between first palliative care consultation and death. One study found no evidence of clinical difference in number of unscheduled admissions (inpatient hospice utilisation), preferred and actual place of death (hospital death) and hospitalisation (people with >14 days of hospitalisation) (n=265; very low quality). There was evidence of clinically important benefit of early referral, with fewer people having 2 or more hospital admissions and people with any number of ICU admissions (n=265, very low quality). However there was also evidence of clinically important benefit of late referral in terms of number of people with 2 or more emergency room visits (n=265; very low quality).</p><p>A second study reported a clinically important benefit of early referral was observed for the outcomes of number of visits to accident and emergency, unscheduled admissions to hospital, hospitalisation (people with >14 days of hospitalisation), preferred and actual place of death (hospital death and ICU death) and avoidable/inappropriate admissions to ICU (n=366; very low quality).</p><p>Another study found a clinically important benefit of early referral was observed for the outcomes of hospitalised in last 3 months of life, death in hospital and median survival (n=99; very low quality).</p></div><div id="ch2.s1.7.1.2"><h5>Early (< 30 days between diagnosis and referral) versus late (> 3 months between diagnosis and referral) referral to palliative care services</h5><p>One study compared referral to palliative care services at < 30 days versus > 3 months between diagnosis and referral. There was no evidence of clinically important difference between groups for quality of life (measured with FACIT-PAL scale) at any time point (n=155; low quality). There was also no clinically important difference in terms of people dying at home between the two groups (n=110; low quality).</p></div><div id="ch2.s1.7.1.3"><h5>Early (> 6 months between first palliative care consultation and death) versus late (< 6 months between first palliative care consultation and death) referral to palliative care services</h5><p>One study compared referral to palliative care services at >6 months versus <6 months between first palliative care consultation and death. Clinically important benefit of early referral was observed for the outcomes of number of visits to accident and emergency, unscheduled admissions to hospital, hospitalisation (people with >14 days of hospitalisation), preferred and actual place of death (hospital death) and avoidable/inappropriate admissions to ICU (n=366; very low quality). There was no clinically important difference between groups for the outcome of preferred and actual place of death (ICU death) (n=366; very low quality).</p></div><div id="ch2.s1.7.1.4"><h5>Early (>30 days between first palliative care consultation and death) versus late (<30 days between first palliative care consultation and death) referral to palliative care services</h5><p>One study compared referral to palliative care services at > 30 days versus < 30 days between first palliative care consultation and death. Clinically important benefit of early referral was observed for the outcomes of death occurring at home or inpatient hospice with early referral (n=842; very low quality).</p></div></div><div id="ch2.s1.7.2"><h4>1.7.2. Health economic evidence statements</h4><p>No relevant economic evaluations were identified.</p></div></div><div id="ch2.s1.8"><h3>1.8. The committee’s discussion of the evidence</h3><div id="ch2.s1.8.1"><h4>1.8.1. Interpreting the evidence</h4><div id="ch2.s1.8.1.1"><h5>1.8.1.1. The outcomes that matter most</h5><p>The Committee identified quality of life, and preferred and actual place of care and death, as the critical outcomes to measure the impact of early or late referral to the provision of palliative care services. These critical outcomes were identified as outcomes that would reflect a direct benefit to the patient as they are about maintaining or improving their quality of life and upholding their choices in the last year of life. The following outcomes were identified as important for decision making and focus on the impact and use of health resources as well as the impact on the patient; length of hospital stay, length of survival, hospitalisation, number of hospital visits, number of visits to accident and emergency, number of unscheduled admissions, use of community services, avoidable/inappropriate admissions to ICU, inappropriate attempts at cardiopulmonary resuscitation and staff, patient and carer satisfaction.</p><p>See tables 7 and 8 in the <a href="/books/NBK558768/bin/bm1.pdf">Methods</a> chapter for a detailed explanation of why the committee selected these outcomes.</p><p>Five studies reported actual place of death, which was used as an indirect outcome for actual place of death compared to preferred place of death. None of the studies reported actual and preferred place of care.</p><p>For the important outcomes, one study reported the number of hospital visits. Two studies reported the outcome length of survival. Two studies reported the number of visits to accident and emergency. Three studies reported the outcome of hospitalisation but none reported whether these were unscheduled or avoidable. Two studies reported number of admissions to hospital and admission to ICU, although there were no details on these being unscheduled, inappropriate or avoidable. No studies reported the use of community services, length of stay, satisfaction of patient or family, inappropriate resuscitation or staff satisfaction.</p></div><div id="ch2.s1.8.1.2"><h5>1.8.1.2. The quality of the evidence</h5><p>The quality of the evidence ranged from very low to low. This was due to study design, selection and performance bias, resulting in a high risk of bias rating, as well as the imprecise nature of the results extracted and analysed in this review. Indirectness in some outcomes (for example: actual and final place of death; hospitalisation) further contributed to the final GRADE rating.</p></div><div id="ch2.s1.8.1.3"><h5>1.8.1.3. Benefits and harms</h5><div id="ch2.s1.8.1.3.1"><h5>Over 30 days and under 30 days</h5><p>Clinical benefit was identified for early compared to late referral for place of death (at home or inpatient hospice (> 30 days versus < 30 days). No clinical differences were identified for early (< 30 days) compared to late referral (> 3 months). There were clinical benefits for early (> 3 months) versus late referral (< 3 month), with fewer hospital and ICU admissions, higher survival and death occurring more in hospital or the ICU.</p></div><div id="ch2.s1.8.1.3.2"><h5>Over 6 months and under 6 months</h5><p>There was a clinical benefit of early referral (> 6 months versus late (< 6 months) for number of visits to accident and emergency, unscheduled admissions to hospital, people with >14 days of hospitalisation, hospital death and avoidable/inappropriate admissions to ICU. No clinically important differences were found between the groups for preferred and actual place of death (ICU death). The results were conflicting across the studies for an increase or reduction in emergency room visits.</p><p>Overall there were more benefits for early referral than late but the committee agreed the evidence was too limited to make a recommendation for a particular time point to have early referral.</p><p>The definition of early and late referral varied across the studies and it was not always clear why the time points where chosen. Two studies had the cut-off of 3 months (with more than 3 months before death considered early and after 3 months delayed), however it is unknown why this cut-off was chosen. One study included the cut-off of 3 months (with more than 3 months before death considered early and after 3 months delayed) and 6 months (with more than 6 months before death considered early and after 6 months delayed). In another study ‘early’ and ‘late’ referral was defined as < 30 days or > 3 months from diagnosis, but no information was reported on the time to death.</p><p>The committee commented that the difference in time of referral was only a few months in the studies and this could explain the absence of evidence for any clinically important differences between the two groups for the majority of the outcomes. One study used 30 days as the cut-off point (with earlier than 30 days considered early and after this considered late). Again this was considered to be a very short time-scale in which to make any clear conclusions of when an appropriate time for referral would be.</p><p>The committee agreed that some of the studies were conducted in different healthcare systems than the UK and this made it difficult to generalise the results to the NHS. Two of the studies were conducted in the US where there are marked differences in the organisation of end of life care and the provision compared to the UK. In addition one study centre was located in a specialist centre making it harder to extrapolate any conclusions from this setting. The other studies were conducted in Norway, Japan and Singapore which have different healthcare systems to the UK. Furthermore, all studies included cancer patients further limiting the generalisability to other populations.</p><p>Overall, the Committee commented that the time between referral to palliative care services and death observed in the studies included in the review was quite short, however, this could be explained at least in part by the challenge of identifying people in the last year of life who would benefit from a referral to palliative care services. The Committee also commented that people who consented to receive early palliative care could be inherently different in severity of illness or in social or cultural factors influencing the make-up of the study populations. The Committee was aware of other studies of early referral to palliative services, however in these studies the comparison was standard care, rather than late referral. The protocol specified including studies which defined ‘early’ and ‘late’ in order to make useful recommendations.</p><p>The Committee concluded there were no negative consequences of early referral to palliative care services but no substantial evidence of benefit either. The Committee concluded that the evidence on benefit of early referral (or provision of) palliative care services for people in the last year of life was not sufficient to formulate a recommendation. However, the Committee agreed to formulate a recommendation to offer initial holistic needs assessment soon after identification of being in the last year of life and for it to be carried out by someone knowledgeable who would be able to identify when and how to carry it out. This was extended to include a recommendation about carer’s needs assessment. The Committee agreed it was important to assess the Carers needs as well. Neglecting the carers needs inevitably impacts on the care the person in the last year of life receives (also see <a href="/books/n/niceng142er8/?report=reader" class="toc-item">evidence review H</a> on carers support services).</p></div></div></div><div id="ch2.s1.8.2"><h4>1.8.2. Cost effectiveness and resource use</h4><p>No economic evidence was identified for this question.</p><p>Referral for early palliative care would cost more in terms of resources spent on palliative care services as people would receive the services for a longer period of time. However the committee acknowledged that receiving palliative care earlier could lead to some people deciding to withdraw from disease modifying or life prolonging treatments earlier. Providing early palliative care could be an efficient use of resources if the costs of providing the services for longer were lower than the costs saved from people withdrawing from (sometimes not cost effective, highly expensive with limited clinical effectiveness) treatments earlier.</p><p>Regardless of this view, the committee felt there were a number of sizeable issues with comparing ‘early’ palliative care to ‘late’ palliative care. A main issue being the inability to define what is meant by the term ‘early’. The significant challenge that exists in identifying when a person is in their last year of life, and even if identified, estimating their life expectancy with accuracy, makes knowing when to begin offering ‘early’ palliative care options extremely problematic. The committee noted that some conditions do not have predictable progression trajectories. It is extremely difficult to estimate the life expectancy of a person who has a condition where it is common for peaks and troughs in symptom severity to occur for example COPD or Heart Failure, or a condition where recovery from treatment may be unlikely but still possible.</p><p>Potential cost savings of early palliative care is dependent on the health care teams having access to resources which are not currently standardised within the NHS. Including these costs may suggest that a saving is not achievable in the short term as significant investment is required in improving resources. Estimating the costs that could be saved from people withdrawing from treatment earlier is even more challenging. Deciding to withdraw from treatment is a personal decision that will vary by condition, by individual circumstance and individual choice.</p><p>Without a clear definition of ‘early’ palliative care and without evidence on the effect that early palliative care has on treatment withdrawal in the entire end of life population, the committee were not able to estimate this effect. The committee were therefore unable to determine the cost effectiveness of early palliative care and did not feel they had enough information to be able to formulate a recommendation on the timing of an assessment.</p><p>The committee agreed that as soon as the health system identifies someone as a carer there should be a system in place that triggers an immediate referral for a carer’s needs assessment to occur as soon after the identification as possible. Early referral for a carer’s assessment will ensure that the carer is supported by and can benefit from the local carer support services available as early as possible.</p></div></div></div><div id="ch2.rl.r1"><h2 id="_ch2_rl_r1_">References</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="ch2.ref1">Adams
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CE, Bader
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J, Horn
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KV. Timing of hospice referral: assessing satisfaction while the patient receives hospice services. Home Health Care Management & Practice. 2009; 21(2):109–116 [<a href="/pmc/articles/PMC2802336/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2802336</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20126517" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20126517</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="ch2.ref2">Alsirafy
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SA, Sroor
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MZ. Referral timing of in-hospital cancer deaths to palliative care in a Saudi tertiary care hospital. Progress in Palliative Care. 2010; 18(2):85–88</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="ch2.ref3">Amano
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I. Association between early palliative care referrals, inpatient hospice utilization, and aggressiveness of care at the end of life. Journal of Palliative Medicine. 2015; 18(3):270–273 [<a href="https://pubmed.ncbi.nlm.nih.gov/25210851" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25210851</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="ch2.ref4">Ansell
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P, Howell
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A, Kite
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et al. What determines referral of UK patients with haematological malignancies to palliative care services? An exploratory study using hospital records. Palliative Medicine. 2007; 21(6):487–492 [<a href="https://pubmed.ncbi.nlm.nih.gov/17846088" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17846088</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="ch2.ref5">Baek
|
|
YJ, Shin
|
|
DW, Choi
|
|
JY, Kang
|
|
J, Mo
|
|
HN, Kim
|
|
YH
|
|
et al. Late referral to palliative care services in Korea. Journal of Pain and Symptom Management. 2011; 41(4):692–699 [<a href="https://pubmed.ncbi.nlm.nih.gov/21232909" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21232909</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="ch2.ref6">Bajwah
|
|
S, Ross
|
|
JR, Wells
|
|
AU, Mohammed
|
|
K, Oyebode
|
|
C, Birring
|
|
SS
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|
et al. Palliative care for patients with advanced fibrotic lung disease: A randomised controlled phase II and feasibility trial of a community case conference intervention. Thorax. 2015; 70(9):830–839 [<a href="https://pubmed.ncbi.nlm.nih.gov/26103995" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26103995</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="ch2.ref7">Bakitas
|
|
MA, Tosteson
|
|
TD, Li
|
|
Z, Lyons
|
|
KD, Hull
|
|
JG, Li
|
|
Z
|
|
et al. Early versus delayed initiation of concurrent palliative oncology care: Patient outcomes in the ENABLE III randomized controlled trial. Journal of Clinical Oncology. 2015; 33(13):1438–1445 [<a href="/pmc/articles/PMC4404422/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4404422</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25800768" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25800768</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="ch2.ref8">Bennett
|
|
MI, Ziegler
|
|
L, Allsop
|
|
M, Daniel
|
|
S, Hurlow
|
|
A. What determines duration of palliative care before death for patients with advanced disease? A retrospective cohort study of community and hospital palliative care provision in a large UK city. BMJ Open. 2016; 6(12):e012576 [<a href="/pmc/articles/PMC5168608/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5168608</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27940628" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27940628</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>9.</dt><dd><div class="bk_ref" id="ch2.ref9">Blackhall
|
|
LJ, Read
|
|
P, Stukenborg
|
|
G, Dillon
|
|
P, Barclay
|
|
J, Romano
|
|
A
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|
et al. CARE track for advanced cancer: Impact and timing of an outpatient palliative care clinic. Journal of Palliative Medicine. 2016; 19(1):57–63 [<a href="/pmc/articles/PMC4692130/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4692130</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26624851" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26624851</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>10.</dt><dd><div class="bk_ref" id="ch2.ref10">Broom
|
|
A, Kirby
|
|
E, Good
|
|
P, Wootton
|
|
J, Adams
|
|
J. Specialists’ experiences and perspectives on the timing of referral to palliative care: A qualitative study. Journal of Palliative Medicine. 2012; 15(11):1248–1253 [<a href="https://pubmed.ncbi.nlm.nih.gov/23039218" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23039218</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>11.</dt><dd><div class="bk_ref" id="ch2.ref11">Bruera
|
|
E, Yennurajalingam
|
|
S. Palliative care in advanced cancer patients: How and when?
|
|
Oncologist. 2012; 17(2):267–273 [<a href="/pmc/articles/PMC3286176/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3286176</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22252934" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22252934</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>12.</dt><dd><div class="bk_ref" id="ch2.ref12">Buchman
|
|
S, Wright
|
|
F, MacKinnon
|
|
M, Walton
|
|
T, Arthurs
|
|
E, Rajmohan
|
|
Y
|
|
et al. Early integration of palliative care in ontario: integrate quality improvement project. Journal of Pain and Symptom Management. 2016; 52(6):e101–e102</div></dd></dl><dl class="bkr_refwrap"><dt>13.</dt><dd><div class="bk_ref" id="ch2.ref13">Caissie
|
|
A, Kevork
|
|
N, Hannon
|
|
B, Le
|
|
LW, Zimmermann
|
|
C. Timing of code status documentation and end-of-life outcomes in patients admitted to an oncology ward. Supportive Care in Cancer. 2014; 22(2):375–381 [<a href="https://pubmed.ncbi.nlm.nih.gov/24077686" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24077686</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>14.</dt><dd><div class="bk_ref" id="ch2.ref14">Campbell
|
|
ML, Guzman
|
|
JA. A proactive approach to improve end-of-life care in a medical intensive care unit for patients with terminal dementia. Critical Care Medicine. 2004; 32(9):1839–1843 [<a href="https://pubmed.ncbi.nlm.nih.gov/15343010" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15343010</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>15.</dt><dd><div class="bk_ref" id="ch2.ref15">Carpenter
|
|
JG, McDarby
|
|
M, Smith
|
|
D, Johnson
|
|
M, Thorpe
|
|
J, Ersek
|
|
M. Associations between timing of palliative care consults and family evaluation of care for veterans who die in a hospice/palliative care unit. Journal of Palliative Medicine. 2017; 20(7):745–751 [<a href="/pmc/articles/PMC5510033/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5510033</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28471732" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28471732</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>16.</dt><dd><div class="bk_ref" id="ch2.ref16">Charalambous
|
|
H, Pallis
|
|
A, Hasan
|
|
B, O’Brien
|
|
M. Attitudes and referral patterns of lung cancer specialists in Europe to Specialized Palliative Care (SPC) and the practice of Early Palliative Care (EPC). BMC Palliative Care. 2014; 13(1):59 [<a href="/pmc/articles/PMC4279692/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4279692</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25550683" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25550683</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>17.</dt><dd><div class="bk_ref" id="ch2.ref17">Christakis
|
|
NA. Timing of referral of terminally ill patients to an outpatient hospice. Journal of General Internal Medicine. 1994; 9(6):314–320 [<a href="https://pubmed.ncbi.nlm.nih.gov/8077995" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8077995</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>18.</dt><dd><div class="bk_ref" id="ch2.ref18">Costantini
|
|
M, Toscani
|
|
F, Gallucci
|
|
M, Brunelli
|
|
C, Miccinesi
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|
G, Tamburini
|
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M
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et al. Terminal cancer patients and timing of referral to palliative care: A Multicenter prospective cohort study. Journal of Pain and Symptom Management. 1999; 18(4):243–252 [<a href="https://pubmed.ncbi.nlm.nih.gov/10534964" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10534964</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>19.</dt><dd><div class="bk_ref" id="ch2.ref19">Curtis
|
|
L, Burns
|
|
A. Unit costs of health & social care 2016. Canterbury. University of Kent Personal Social Services Research Unit, 2016.</div></dd></dl><dl class="bkr_refwrap"><dt>20.</dt><dd><div class="bk_ref" id="ch2.ref20">Department of Health. NHS reference costs 2015–16. 2016. Available from: <a href="https://www.gov.uk/government/publications/nhs-reference-costs-collection-guidance-for-2015-to-2016" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.gov.uk/government<wbr style="display:inline-block"></wbr>​/publications<wbr style="display:inline-block"></wbr>​/nhs-reference-costs-collection-guidance-for-2015-to-2016</a> Last accessed: 25/08/2017.</div></dd></dl><dl class="bkr_refwrap"><dt>21.</dt><dd><div class="bk_ref" id="ch2.ref21">Devi
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PS. A timely referral to palliative care team improves quality of life. Indian Journal of Palliative Care. 2011; 17(Suppl):S14–16 [<a href="/pmc/articles/PMC3140091/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3140091</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21811360" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21811360</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>22.</dt><dd><div class="bk_ref" id="ch2.ref22">Diamond
|
|
EL, Russell
|
|
D, Kryza-Lacombe
|
|
M, Bowles
|
|
KH, Applebaum
|
|
AJ, Dennis
|
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J
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|
et al. Rates and risks for late referral to hospice in patients with primary malignant brain tumors. Neuro-Oncology. 2016; 18(1):78–86 [<a href="/pmc/articles/PMC4677417/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4677417</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26261221" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26261221</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>23.</dt><dd><div class="bk_ref" id="ch2.ref23">Drieskens
|
|
K, Bilsen
|
|
J, Van Den Block
|
|
L, Deschepper
|
|
R, Bauwens
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S, Distelmans
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W
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et al. Characteristics of referral to a multidisciplinary palliative home care team. Journal of Palliative Care. 2008; 24(3):162–166 [<a href="https://pubmed.ncbi.nlm.nih.gov/18942566" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18942566</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>24.</dt><dd><div class="bk_ref" id="ch2.ref24">Fink
|
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RM. Review of a study on late referral to a palliative care consultation service: length of stay and in-hospital mortality outcomes. Journal of the Advanced Practitioner in Oncology. 2015; 6(6):597–601 [<a href="/pmc/articles/PMC5017550/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5017550</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27648349" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27648349</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>25.</dt><dd><div class="bk_ref" id="ch2.ref25">Fukui
|
|
S, Fujita
|
|
J, Tsujimura
|
|
M, Sumikawa
|
|
Y, Hayashi
|
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Y, Fukui
|
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N. Late referrals to home palliative care service affecting death at home in advanced cancer patients in Japan: A nationwide survey. Annals of Oncology. 2011; 22(9):2113–2120 [<a href="https://pubmed.ncbi.nlm.nih.gov/21307157" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21307157</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>26.</dt><dd><div class="bk_ref" id="ch2.ref26">Ghazali
|
|
N, Kanatas
|
|
A, Langley
|
|
DJ, Scott
|
|
B, Lowe
|
|
D, Rogers
|
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SN. Treatment referral before and after the introduction of the Liverpool Patients Concerns Inventory (PCI) into routine head and neck oncology outpatient clinics. Supportive Care in Cancer. 2011; 19(11):1879–1886 [<a href="https://pubmed.ncbi.nlm.nih.gov/21725827" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21725827</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>27.</dt><dd><div class="bk_ref" id="ch2.ref27">Glare
|
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PA. Early implementation of palliative care can improve patient outcomes. Journal of the National Comprehensive Cancer Network. 2013; 11: Suppl 1:S3–9 [<a href="https://pubmed.ncbi.nlm.nih.gov/23520184" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23520184</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>28.</dt><dd><div class="bk_ref" id="ch2.ref28">Greer
|
|
JA, Pirl
|
|
WF, Jackson
|
|
VA, Muzikansky
|
|
A, Lennes
|
|
IT, Heist
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|
RS
|
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et al. Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancer. Journal of Clinical Oncology. 2012; 30(4):394–400 [<a href="https://pubmed.ncbi.nlm.nih.gov/22203758" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22203758</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>29.</dt><dd><div class="bk_ref" id="ch2.ref29">Groenvold
|
|
M, Petersen
|
|
MA, Damkier
|
|
A, Neergaard
|
|
MA, Nielsen
|
|
JB, Pedersen
|
|
L
|
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et al. Randomised clinical trial of early specialist palliative care plus standard care versus standard care alone in patients with advanced cancer: The Danish Palliative Care Trial. Palliative Medicine. 2017:269216317705100 [<a href="https://pubmed.ncbi.nlm.nih.gov/28494643" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28494643</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>30.</dt><dd><div class="bk_ref" id="ch2.ref30">Gu
|
|
X, Cheng
|
|
W, Chen
|
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M, Liu
|
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M, Zhang
|
|
Z. Timing of referral to inpatient palliative care services for advanced cancer patients and earlier referral predictors in mainland China. Palliative & Supportive Care. 2016; 14(5):503–509 [<a href="https://pubmed.ncbi.nlm.nih.gov/26481125" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26481125</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>31.</dt><dd><div class="bk_ref" id="ch2.ref31">Gunatilake
|
|
S, Brims
|
|
FJ, Fogg
|
|
C, Lawrie
|
|
I, Maskell
|
|
N, Forbes
|
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K
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et al. A multicentre non-blinded randomised controlled trial to assess the impact of regular early specialist symptom control treatment on quality of life in malignant mesothelioma (RESPECT-MESO): study protocol for a randomised controlled trial. Trials. 2014; 15:367 [<a href="/pmc/articles/PMC4180732/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4180732</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25238873" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25238873</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>32.</dt><dd><div class="bk_ref" id="ch2.ref32">Haun
|
|
MW, Estel
|
|
S, Rucker
|
|
G, Friederich
|
|
HC, Villalobos
|
|
M, Thomas
|
|
M
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et al. Early palliative care for adults with advanced cancer. Cochrane Database of Systematic Reviews
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|
|
K, De Almeida Mello
|
|
J, Spruytte
|
|
N, Cohen
|
|
J, Van Audenhove
|
|
C, Declercq
|
|
A. Does using the interRAI Palliative Care instrument reduce the needs and symptoms of nursing home residents receiving palliative care?
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Palliative & Supportive Care. 2017; Epublication [<a href="https://pubmed.ncbi.nlm.nih.gov/28374656" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28374656</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>34.</dt><dd><div class="bk_ref" id="ch2.ref34">Higginson
|
|
IJ, Hart
|
|
S, Burman
|
|
R, Silber
|
|
E, Saleem
|
|
T, Edmonds
|
|
P. Randomised controlled trial of a new palliative care service: Compliance, recruitment and completeness of follow-up. BMC Palliative Care. 2008; 7:7 [<a href="/pmc/articles/PMC2442830/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2442830</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18507817" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18507817</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>35.</dt><dd><div class="bk_ref" id="ch2.ref35">Hui
|
|
D, Kim
|
|
SH, Roquemore
|
|
J, Dev
|
|
R, Chisholm
|
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G, Bruera
|
|
E. Impact of timing and setting of palliative care referral on quality of end-of-life care in cancer patients. Cancer. 2014; 120(11):1743–1749 [<a href="/pmc/articles/PMC4073257/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4073257</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24967463" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24967463</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>36.</dt><dd><div class="bk_ref" id="ch2.ref36">Hui
|
|
D, Meng
|
|
YC, Bruera
|
|
S, Geng
|
|
Y, Hutchins
|
|
R, Mori
|
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M
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et al. Referral criteria for outpatient palliative cancer care: A systematic review. Oncologist. 2016; 21(7):895–901 [<a href="/pmc/articles/PMC4943399/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4943399</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27185614" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27185614</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>37.</dt><dd><div class="bk_ref" id="ch2.ref37">Humphreys
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J, Harman
|
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S. Late referral to palliative care consultation service: Length of stay and in-hospital mortality outcomes. Journal of Community and Supportive Oncology. 2014; 12(4):129–136 [<a href="https://pubmed.ncbi.nlm.nih.gov/24971422" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24971422</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>38.</dt><dd><div class="bk_ref" id="ch2.ref38">Jacobsen
|
|
J, Jackson
|
|
V, Dahlin
|
|
C, Greer
|
|
J, Perez-Cruz
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P, Billings
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|
JA
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et al. Components of early outpatient palliative care consultation in patients with metastatic nonsmall cell lung cancer. Journal of Palliative Medicine. 2011; 14(4):459–464 [<a href="https://pubmed.ncbi.nlm.nih.gov/21417739" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21417739</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>39.</dt><dd><div class="bk_ref" id="ch2.ref39">Johnsen
|
|
AT, Damkier
|
|
A, Vejlgaard
|
|
TB, Lindschou
|
|
J, Sjogren
|
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P, Gluud
|
|
C
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MJ, Gadoud
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A. Palliative care for people with chronic heart failure: When is it time?
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Journal of Palliative Care. 2011; 27(1):37–42 [<a href="https://pubmed.ncbi.nlm.nih.gov/21510130" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21510130</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>41.</dt><dd><div class="bk_ref" id="ch2.ref41">King
|
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JD, Eickhoff
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J, Traynor
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A, Campbell
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TC. Integrated onco-palliative care associated with prolonged survival compared to standard care for patients with advanced lung cancer: A retrospective review. Journal of Pain and Symptom Management. 2016; 51(6):1027–1032 [<a href="https://pubmed.ncbi.nlm.nih.gov/26948411" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26948411</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>42.</dt><dd><div class="bk_ref" id="ch2.ref42">Kozlov
|
|
E, Carpenter
|
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BD, Thorsten
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M, Heiland
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M, Agarwal
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A. Timing of palliative care consultations and recommendations: understanding the variability. American Journal of Hospice & Palliative Medicine. 2015; 32(7):772–775 [<a href="https://pubmed.ncbi.nlm.nih.gov/25024458" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25024458</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>43.</dt><dd><div class="bk_ref" id="ch2.ref43">Lamba
|
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S, Nagurka
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R, Zielinski
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A, Scott
|
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SR. Palliative care provision in the emergency department: Barriers reported by emergency physicians. Journal of Palliative Medicine. 2013; 16(2):143–147 [<a href="https://pubmed.ncbi.nlm.nih.gov/23305188" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23305188</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>44.</dt><dd><div class="bk_ref" id="ch2.ref44">Lamont
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EB, Christakis
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NA. Physician factors in the timing of cancer patient referral to hospice palliative care. Cancer. 2002; 94(10):2733–2737 [<a href="https://pubmed.ncbi.nlm.nih.gov/12173344" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12173344</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>45.</dt><dd><div class="bk_ref" id="ch2.ref45">Le
|
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BH, Mileshkin
|
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L, Doan
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K, Saward
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D, Spruyt
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O, Yoong
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BH, Watt
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JN. Care of the dying in Australia’s busiest hospital: benefits of palliative care consultation and methods to enhance access. Journal of Palliative Medicine. 2010; 13(7):855–860 [<a href="https://pubmed.ncbi.nlm.nih.gov/20636157" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20636157</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>47.</dt><dd><div class="bk_ref" id="ch2.ref47">LeBlanc
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TW, El-Jawahri
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A. When and why should patients with hematologic malignancies see a palliative care specialist?
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|
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M, Rhondali
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W, Lafumas
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V, Berthiller
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J, Teissere
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M, Piegay
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|
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YJ, Yang
|
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JH, Lee
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JW, Yoon
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J, Nah
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JR, Choi
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WS
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|
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WJ, Lowery
|
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AW, Barnett
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JC, Lopez-Acevedo
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M, Lee
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PS, Secord
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AA
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|
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JR, apG Vaughn
|
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EA, Northouse
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B, Suhong
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T, Dorneman
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LA, Foreman
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NK
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|
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M, Scarpi
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E, Dall’Agata
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M, Schiavon
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S, Biasini
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C, Codeca
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|
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M, Scarpi
|
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E, Dall’Agata
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M, Zagonel
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V, Berte
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R, Ferrari
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|
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P, Garrido
|
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MM, Cassel
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JB, Kelley
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AS, Meier
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DE, Normand
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J, Swami
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N, Hannon
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B, Lo
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C, Pope
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A, Oza
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|
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J, Swami
|
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N, Hannon
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B, Pope
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A, Oza
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A, Leighl
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|
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BA, Rosenwax
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LK, Murray
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K, Currow
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DC. Early admission to community-based palliative care reduces use of emergency departments in the ninety days before death. Journal of Palliative Medicine. 2013; 16(7):774–779 [<a href="https://pubmed.ncbi.nlm.nih.gov/23676094" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23676094</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>58.</dt><dd><div class="bk_ref" id="ch2.ref58">Meffert
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C, Gaertner
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J, Seibel
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K, Jors
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K, Bardenheuer
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H, Buchheidt
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443 [<a href="/pmc/articles/PMC4448282/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4448282</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26022223" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26022223</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>59.</dt><dd><div class="bk_ref" id="ch2.ref59">Miller
|
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SC, Lima
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JC, Intrator
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O, Martin
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E, Bull
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J, Hanson
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LC. Palliative care consultations in nursing homes and reductions in acute care use and potentially burdensome end-of-life transitions. Journal of the American Geriatrics Society. 2016; 64(11):2280–2287 [<a href="/pmc/articles/PMC5118125/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5118125</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27641157" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27641157</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>60.</dt><dd><div class="bk_ref" id="ch2.ref60">Morita
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T, Akechi
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T, Ikenaga
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M, Kizawa
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Y, Kohara
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H, Mukaiyama
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T, Miyashita
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M, Tsuneto
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S, Sato
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K, Shima
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Y. Late referrals to palliative care units in Japan: Nationwide follow-up survey and effects of palliative care team involvement after the Cancer Control Act. Journal of Pain and Symptom Management. 2009; 38(2):191–196 [<a href="https://pubmed.ncbi.nlm.nih.gov/19515529" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19515529</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>62.</dt><dd><div class="bk_ref" id="ch2.ref62">Nakajima
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N, Abe
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Y. Concurrent Specialized Palliative Care Upon Initiation of First-Line Chemotherapy for Cancer Progression: Is It Early Enough?
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American Journal of Hospice & Palliative Medicine. 2016; 33(4):340–345 [<a href="https://pubmed.ncbi.nlm.nih.gov/25433067" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25433067</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>63.</dt><dd><div class="bk_ref" id="ch2.ref63">National Institute for Health and Care Excellence. Developing NICE guidelines: the manual. London. National Institute for Health and Care Excellence, 2014. Available from: <a href="http://www.nice.org.uk/article/PMG20/chapter/1%20Introduction%20and%20overview" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.nice.org.uk<wbr style="display:inline-block"></wbr>​/article/PMG20/chapter<wbr style="display:inline-block"></wbr>​/1%20Introduction%20and%20overview</a> [<a href="https://pubmed.ncbi.nlm.nih.gov/26677490" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26677490</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>64.</dt><dd><div class="bk_ref" id="ch2.ref64">Nieder
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C, Tollali
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T, Haukland
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E, Reigstad
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A, Flatoy
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LR, Engljahringer
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K. Impact of early palliative interventions on the outcomes of care for patients with non-small cell lung cancer. Supportive Care in Cancer. 2016; 24(10):4385–4391 [<a href="https://pubmed.ncbi.nlm.nih.gov/27209479" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27209479</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>65.</dt><dd><div class="bk_ref" id="ch2.ref65">Nipp
|
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RD, Greer
|
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JA, El-Jawahri
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A, Traeger
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L, Gallagher
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ER, Park
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|
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SA, Hogan
|
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LA, Holloway
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RG, Temkin-Greener
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H, Buckley
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MJ, O’Brien
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AC, Murphy
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M, Crowley
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CM, Leahy
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HM, McCarthy
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JV, Do
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CA, Williams
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E, Harrold
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|
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RF, Slusser
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K, Power
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S, Jones
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CA, LeBlanc
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TW, Kamal
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AH
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AM, Gade
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KE, Nielsen
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G, Havard
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R, Harrison
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ER, Teno
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JS, Billings
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JA, Jackson
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VA, Reid
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C, Dahlin
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CM, Kornblith
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JS, Greer
|
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JA, El-Jawahri
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A, Pirl
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WF, Park
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ER, Jackson
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VA
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et al. Effects of early integrated palliative care in patients with lung and GI Cancer: A randomized clinical trial. Journal of Clinical Oncology. 2017; 35(8):834–841 [<a href="/pmc/articles/PMC5455686/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5455686</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28029308" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28029308</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>78.</dt><dd><div class="bk_ref" id="ch2.ref78">Temel
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JS, Greer
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JA, Muzikansky
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A, Gallagher
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ER, Admane
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S, Jackson
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VA
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et al. Early palliative care for patients with metastatic non-small-cell lung cancer. The New England journal of medicine. 2010; 363(8):733–742 [<a href="https://pubmed.ncbi.nlm.nih.gov/20818875" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20818875</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>79.</dt><dd><div class="bk_ref" id="ch2.ref79">Teno
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JM, Shu
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JE, Casarett
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D, Spence
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C, Rhodes
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R, Connor
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S. Timing of referral to hospice and quality of care: Length of stay and bereaved family members’ perceptions of the timing of hospice referral. Journal of Pain and Symptom Management. 2007; 34(2):120–125 [<a href="https://pubmed.ncbi.nlm.nih.gov/17583469" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17583469</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>80.</dt><dd><div class="bk_ref" id="ch2.ref80">Thoonsen
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B, Groot
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M, Engels
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Y, Prins
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J, Verhagen
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S, Galesloot
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C
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et al. Early identification of and proactive palliative care for patients in general practice, incentive and methods of a randomized controlled trial. BMC Family Practice. 2011; 12:123 [<a href="/pmc/articles/PMC3228678/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3228678</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22050863" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22050863</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>81.</dt><dd><div class="bk_ref" id="ch2.ref81">Vanbutsele
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G, Van Belle
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S, De Laat
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M, Surmont
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V, Geboes
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K, Eecloo
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K
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et al. The systematic early integration of palliative care into multidisciplinary oncology care in the hospital setting (IPAC), a randomized controlled trial: The study protocol. BMC Health Services Research. 2015; 15:554 [<a href="/pmc/articles/PMC4678668/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4678668</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26666301" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26666301</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>82.</dt><dd><div class="bk_ref" id="ch2.ref82">von Gunten
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CF, Lutz
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S, Ferris
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FD. Why oncologists should refer patients earlier for hospice care. Oncology. 2011; 25(13):1278–1280, 1282–1285 [<a href="https://pubmed.ncbi.nlm.nih.gov/22272498" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22272498</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>83.</dt><dd><div class="bk_ref" id="ch2.ref83">Weber
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C, Stirnemann
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J, Herrmann
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FR, Pautex
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S, Janssens
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JP. Can early introduction of specialized palliative care limit intensive care, emergency and hospital admissions in patients with severe and very severe COPD? a randomized study. BMC Palliative Care. 2016; 13:47 [<a href="/pmc/articles/PMC4448287/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4448287</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25927907" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25927907</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>84.</dt><dd><div class="bk_ref" id="ch2.ref84">Yamagishi
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A, Morita
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T, Kawagoe
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S, Shimizu
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M, Ozawa
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T, An
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E
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et al. Length of home hospice care, family-perceived timing of referrals, perceived quality of care, and quality of death and dying in terminally ill cancer patients who died at home. Supportive Care in Cancer. 2015; 23(2):491–499 [<a href="https://pubmed.ncbi.nlm.nih.gov/25142705" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25142705</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>85.</dt><dd><div class="bk_ref" id="ch2.ref85">Zagonel
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V, Torta
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R, Franciosi
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V, Brunello
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A, Biasco
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G, Cattaneo
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D
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et al. Early integration of palliative care in oncology practice: results of the Italian Association of Medical Oncology (AIOM) survey. Journal of Cancer. 2016; 7(14):1968–1978 [<a href="/pmc/articles/PMC5118660/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5118660</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27877212" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27877212</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>86.</dt><dd><div class="bk_ref" id="ch2.ref86">Zambrano
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SC, Fliedner
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MC, Eychmuller
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S. The impact of early palliative care on the quality of care during the last days of life: What does the evidence say?
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Current Opinion in Supportive & Palliative Care. 2016; 10(4):310–315 [<a href="https://pubmed.ncbi.nlm.nih.gov/27635766" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27635766</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>87.</dt><dd><div class="bk_ref" id="ch2.ref87">Zimmermann
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C, Swami
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N, Krzyzanowska
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M, Hannon
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B, Leighl
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N, Oza
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A
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et al. Early palliative care for patients with advanced cancer: A cluster-randomised controlled trial. Lancet. 2014; 383(9930):1721–1730 [<a href="https://pubmed.ncbi.nlm.nih.gov/24559581" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24559581</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>88.</dt><dd><div class="bk_ref" id="ch2.ref88">Zimmermann
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C, Swami
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N, Krzyzanowska
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M, Leighl
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N, Rydall
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A, Rodin
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G
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et al. Perceptions of palliative care among patients with advanced cancer and their caregivers. CMAJ Canadian Medical Association Journal. 2016; 188(10):E217–227 [<a href="/pmc/articles/PMC4938707/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4938707</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27091801" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27091801</span></a>]</div></dd></dl></dl></div><div id="appendixesappgroup2"><h2 id="_appendixesappgroup2_">Appendices</h2><div id="ch2.appa"><h3>Appendix A. Review protocols</h3><p id="ch2.appa.tab1"><a href="/books/NBK558768/table/ch2.appa.tab1/?report=objectonly" target="object" rid-ob="figobch2appatab1" class="figpopup">Table 10. Review protocol: Early versus late referral to palliative care services</a></p><p id="ch2.appa.tab2"><a href="/books/NBK558768/table/ch2.appa.tab2/?report=objectonly" target="object" rid-ob="figobch2appatab2" class="figpopup">Table 11. Health economic review protocol</a></p></div><div id="ch2.appb"><h3>Appendix B. Literature search strategies</h3><p>The literature searches for this review are detailed below and complied with the methodology outlined in Developing NICE guidelines: the manual 2014, updated 2017 <a href="https://www.nice.org.uk/guidance/pmg20/resources/developing-nice-guidelines-the-manual-pdf-72286708700869" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www.nice.org.uk/guidance/pmg20/resources/developing-nice-guidelines-the-manual-pdf-72286708700869</a></p><p><i>For more detailed information, please see the</i>
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<a href="/books/NBK558768/bin/bm1.pdf">Methodology</a>
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<i>Review</i>.</p><div id="ch2.appb.s1"><h4>B.1. Clinical search literature search strategy</h4><p>Searches for were constructed using a PICO framework where population (P) terms were combined with Intervention (I) and in some cases Comparison (C) terms. Outcomes (O) are rarely used in search strategies for interventions as these concepts may not be well described in title, abstract or indexes and therefore difficult to retrieve. Search filters were applied to the search where appropriate.</p><p id="ch2.appb.tab1"><a href="/books/NBK558768/table/ch2.appb.tab1/?report=objectonly" target="object" rid-ob="figobch2appbtab1" class="figpopup">Table 12. Database date parameters and filters used</a></p><p id="ch2.appb.tab2"><a href="/books/NBK558768/table/ch2.appb.tab2/?report=objectonly" target="object" rid-ob="figobch2appbtab2" class="figpopup">Medline (Ovid) search terms</a></p><p id="ch2.appb.tab3"><a href="/books/NBK558768/table/ch2.appb.tab3/?report=objectonly" target="object" rid-ob="figobch2appbtab3" class="figpopup">Embase (Ovid) search terms</a></p><p id="ch2.appb.tab4"><a href="/books/NBK558768/table/ch2.appb.tab4/?report=objectonly" target="object" rid-ob="figobch2appbtab4" class="figpopup">Cochrane Library (Wiley) search terms</a></p><p id="ch2.appb.tab5"><a href="/books/NBK558768/table/ch2.appb.tab5/?report=objectonly" target="object" rid-ob="figobch2appbtab5" class="figpopup">CINAHL (EBSCO) search terms</a></p><p id="ch2.appb.tab6"><a href="/books/NBK558768/table/ch2.appb.tab6/?report=objectonly" target="object" rid-ob="figobch2appbtab6" class="figpopup">PsycINFO (ProQuest) search terms</a></p><p id="ch2.appb.tab7"><a href="/books/NBK558768/table/ch2.appb.tab7/?report=objectonly" target="object" rid-ob="figobch2appbtab7" class="figpopup">HMIC (Ovid) search terms</a></p><p id="ch2.appb.tab8"><a href="/books/NBK558768/table/ch2.appb.tab8/?report=objectonly" target="object" rid-ob="figobch2appbtab8" class="figpopup">SPP (Ovid) search terms</a></p><p id="ch2.appb.tab9"><a href="/books/NBK558768/table/ch2.appb.tab9/?report=objectonly" target="object" rid-ob="figobch2appbtab9" class="figpopup">ASSIA (ProQuest) search terms</a></p></div><div id="ch2.appb.s2"><h4>B.2. Health Economics literature search strategy</h4><p>Health economic evidence was identified by conducting a broad search relating to end of life care in NHS Economic Evaluation Database (NHS EED – this ceased to be updated after March 2015) and the Health Technology Assessment database (HTA) with no date restrictions. NHS EED and HTA databases are hosted by the Centre for Research and Dissemination (CRD). Additional searches were run on Medline and Embase for health economics, economic modelling and quality of life studies.</p><p id="ch2.appb.tab10"><a href="/books/NBK558768/table/ch2.appb.tab10/?report=objectonly" target="object" rid-ob="figobch2appbtab10" class="figpopup">Table 13. Database date parameters and filters used</a></p><p id="ch2.appb.tab11"><a href="/books/NBK558768/table/ch2.appb.tab11/?report=objectonly" target="object" rid-ob="figobch2appbtab11" class="figpopup">Medline (Ovid) search terms</a></p><p id="ch2.appb.tab12"><a href="/books/NBK558768/table/ch2.appb.tab12/?report=objectonly" target="object" rid-ob="figobch2appbtab12" class="figpopup">Embase (Ovid) search terms</a></p><p id="ch2.appb.tab13"><a href="/books/NBK558768/table/ch2.appb.tab13/?report=objectonly" target="object" rid-ob="figobch2appbtab13" class="figpopup">NHS EED and HTA (CRD) search terms</a></p></div></div><div id="ch2.appc"><h3>Appendix C. Clinical evidence selection</h3><p id="ch2.appc.fig1"><a href="/books/NBK558768/figure/ch2.appc.fig1/?report=objectonly" target="object" rid-ob="figobch2appcfig1" class="figpopup">Figure 1. Flow chart of clinical study selection for the review of information sharing</a></p><p id="ch2.appc.fig2"><a href="/books/NBK558768/figure/ch2.appc.fig2/?report=objectonly" target="object" rid-ob="figobch2appcfig2" class="figpopup">Figure 2. Flow chart of health economic study selection for the guideline</a></p></div><div id="ch2.appd"><h3>Appendix D. Clinical evidence tables</h3><p id="ch2.appd.et1"><a href="/books/NBK558768/bin/ch2-appd-et1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Download PDF</a><span class="small"> (229K)</span></p></div><div id="ch2.appe"><h3>Appendix E. Forest plots</h3><div id="ch2.appe.s1"><h4>E.1. Early referral to (or provision of) palliative care services versus late referral to (or provision of) palliative care services in people in their last year of life</h4><div id="ch2.appe.s1.1"><h5>E.1.1. Early (> 3 months between first palliative care consultation and death) versus late (< 3 months between first palliative care consultation and death) referral to palliative care services</h5><p id="ch2.appe.fig3"><a href="/books/NBK558768/figure/ch2.appe.fig3/?report=objectonly" target="object" rid-ob="figobch2appefig3" class="figpopup">Figure 3. Number of unscheduled admissions (inpatient hospice utilisation) up to death</a></p><p id="ch2.appe.fig4"><a href="/books/NBK558768/figure/ch2.appe.fig4/?report=objectonly" target="object" rid-ob="figobch2appefig4" class="figpopup">Figure 4. Preferred and actual place of death (Hospital deaths)</a></p><p id="ch2.appe.fig5"><a href="/books/NBK558768/figure/ch2.appe.fig5/?report=objectonly" target="object" rid-ob="figobch2appefig5" class="figpopup">Figure 5. Number of visits to accident and emergency (People with ≥2 emergency room visits) within last 30 days of life</a></p><p id="ch2.appe.fig6"><a href="/books/NBK558768/figure/ch2.appe.fig6/?report=objectonly" target="object" rid-ob="figobch2appefig6" class="figpopup">Figure 6. Number of unscheduled admissions at hospital (People with ≥2 hospital admissions) within last 30 days of life</a></p><p id="ch2.appe.fig7"><a href="/books/NBK558768/figure/ch2.appe.fig7/?report=objectonly" target="object" rid-ob="figobch2appefig7" class="figpopup">Figure 7. Hospitalisation (People with >14 days of hospital admission) within last 30 days of life</a></p><p id="ch2.appe.fig8"><a href="/books/NBK558768/figure/ch2.appe.fig8/?report=objectonly" target="object" rid-ob="figobch2appefig8" class="figpopup">Figure 8. Avoidable/inappropriate admissions to ICU (People with any ICU admissions)</a></p><p id="ch2.appe.fig9"><a href="/books/NBK558768/figure/ch2.appe.fig9/?report=objectonly" target="object" rid-ob="figobch2appefig9" class="figpopup">Figure 9. Number of visits to accident and emergency (people with any number of emergency room visits) within last 30 days of life</a></p><p id="ch2.appe.fig10"><a href="/books/NBK558768/figure/ch2.appe.fig10/?report=objectonly" target="object" rid-ob="figobch2appefig10" class="figpopup">Figure 10. Number of unscheduled admissions at hospital (People with any number of hospital admissions) within last 30 days of life</a></p><p id="ch2.appe.fig11"><a href="/books/NBK558768/figure/ch2.appe.fig11/?report=objectonly" target="object" rid-ob="figobch2appefig11" class="figpopup">Figure 11. Preferred and actual place of death (ICU deaths)</a></p><p id="ch2.appe.fig12"><a href="/books/NBK558768/figure/ch2.appe.fig12/?report=objectonly" target="object" rid-ob="figobch2appefig12" class="figpopup">Figure 12. Hospitalisation (Hospitalised in the last 3 months of life)</a></p></div><div id="ch2.appe.s1.2"><h5>E.1.2. Early (within 30 days of diagnosis of advanced cancer) versus late (> 3 months of diagnosis of advanced cancer) referral to palliative care services</h5><p id="ch2.appe.fig13"><a href="/books/NBK558768/figure/ch2.appe.fig13/?report=objectonly" target="object" rid-ob="figobch2appefig13" class="figpopup">Figure 13. Quality of life at 3 months (FACET-Pal, 0–184)</a></p><p id="ch2.appe.fig14"><a href="/books/NBK558768/figure/ch2.appe.fig14/?report=objectonly" target="object" rid-ob="figobch2appefig14" class="figpopup">Figure 14. Quality of life at 6 months (FACET-Pal, 0–184)</a></p><p id="ch2.appe.fig15"><a href="/books/NBK558768/figure/ch2.appe.fig15/?report=objectonly" target="object" rid-ob="figobch2appefig15" class="figpopup">Figure 15. Quality of life at 12 months (FACET-Pal, 0–184)</a></p><p id="ch2.appe.fig16"><a href="/books/NBK558768/figure/ch2.appe.fig16/?report=objectonly" target="object" rid-ob="figobch2appefig16" class="figpopup">Figure 16. Place of death (participants who died at home)</a></p></div><div id="ch2.appe.s1.3"><h5>E.1.4. Early (> 6 months between first palliative care consultation and death) versus late (< 6 months between first palliative care consultation and death) referral to palliative care services</h5><p id="ch2.appe.fig17"><a href="/books/NBK558768/figure/ch2.appe.fig17/?report=objectonly" target="object" rid-ob="figobch2appefig17" class="figpopup">Figure 17. Number of visits to accident and emergency (People with any number of emergency room visits) within last 30 days of life</a></p><p id="ch2.appe.fig18"><a href="/books/NBK558768/figure/ch2.appe.fig18/?report=objectonly" target="object" rid-ob="figobch2appefig18" class="figpopup">Figure 18. Number of visits to accident and emergency (People with ≥2 emergency room visits) within last 30 days of life</a></p><p id="ch2.appe.fig19"><a href="/books/NBK558768/figure/ch2.appe.fig19/?report=objectonly" target="object" rid-ob="figobch2appefig19" class="figpopup">Figure 19. Number of unscheduled admissions at hospital (People with any number of hospital admissions) within last 30 days of life</a></p><p id="ch2.appe.fig20"><a href="/books/NBK558768/figure/ch2.appe.fig20/?report=objectonly" target="object" rid-ob="figobch2appefig20" class="figpopup">Figure 20. Number of unscheduled admissions at hospital (People with ≥2 hospital admissions) within last 30 days of life</a></p><p id="ch2.appe.fig21"><a href="/books/NBK558768/figure/ch2.appe.fig21/?report=objectonly" target="object" rid-ob="figobch2appefig21" class="figpopup">Figure 21. Hospitalisation (People with >14 days of hospital admission) within last 30 days of life</a></p><p id="ch2.appe.fig22"><a href="/books/NBK558768/figure/ch2.appe.fig22/?report=objectonly" target="object" rid-ob="figobch2appefig22" class="figpopup">Figure 22. Preferred and actual place of death (Hospital deaths)</a></p><p id="ch2.appe.fig23"><a href="/books/NBK558768/figure/ch2.appe.fig23/?report=objectonly" target="object" rid-ob="figobch2appefig23" class="figpopup">Figure 23. Preferred and actual place of death (ICU deaths)</a></p><p id="ch2.appe.fig24"><a href="/books/NBK558768/figure/ch2.appe.fig24/?report=objectonly" target="object" rid-ob="figobch2appefig24" class="figpopup">Figure 24. Avoidable/inappropriate admissions to ICU (People with any ICU admissions) within last 30 days of life</a></p></div><div id="ch2.appe.s1.4"><h5>E.1.6. Early (palliative care >30 days before death) versus late (palliative care <30 days before death)</h5><p id="ch2.appe.fig25"><a href="/books/NBK558768/figure/ch2.appe.fig25/?report=objectonly" target="object" rid-ob="figobch2appefig25" class="figpopup">Figure 25. Preferred and actual place of death (home deaths – male patients)</a></p><p id="ch2.appe.fig26"><a href="/books/NBK558768/figure/ch2.appe.fig26/?report=objectonly" target="object" rid-ob="figobch2appefig26" class="figpopup">Figure 26. Preferred and actual place of death (home deaths – female patients)</a></p><p id="ch2.appe.fig27"><a href="/books/NBK558768/figure/ch2.appe.fig27/?report=objectonly" target="object" rid-ob="figobch2appefig27" class="figpopup">Figure 27. Preferred and actual place of death (inpatient hospice deaths – male patients)</a></p><p id="ch2.appe.fig28"><a href="/books/NBK558768/figure/ch2.appe.fig28/?report=objectonly" target="object" rid-ob="figobch2appefig28" class="figpopup">Figure 28. Preferred and actual place of death (inpatient hospice deaths – female patients)</a></p></div></div></div><div id="ch2.appf"><h3>Appendix F. GRADE tables</h3><p id="ch2.appf.tab1"><a href="/books/NBK558768/table/ch2.appf.tab1/?report=objectonly" target="object" rid-ob="figobch2appftab1" class="figpopup">Table 14. Clinical evidence profile: Early (> 3 months between first palliative care consultation and death) versus late (< 3 months between first palliative care consultation and death) referral to palliative care services</a></p><p id="ch2.appf.tab2"><a href="/books/NBK558768/table/ch2.appf.tab2/?report=objectonly" target="object" rid-ob="figobch2appftab2" class="figpopup">Table 15. Clinical evidence profile: Early (> 30 days between diagnosis and referral) versus late (< 3 months between diagnosis and referral) referral to palliative care services</a></p><p id="ch2.appf.tab3"><a href="/books/NBK558768/table/ch2.appf.tab3/?report=objectonly" target="object" rid-ob="figobch2appftab3" class="figpopup">Table 16. Clinical evidence profile: Early (> 6 months between first palliative care consultation and death) versus late (< 6months between first palliative care consultation and death) referral to palliative care services</a></p><p id="ch2.appf.tab4"><a href="/books/NBK558768/table/ch2.appf.tab4/?report=objectonly" target="object" rid-ob="figobch2appftab4" class="figpopup">Table 17. Clinical evidence profile: Early (palliative care >30 days before death) versus late (palliative care <30 days before death)</a></p></div><div id="ch2.appg"><h3>Appendix G. Excluded studies</h3><div id="ch2.appg.s1"><h4>G.1. Excluded clinical studies</h4><p id="ch2.appg.tab1"><a href="/books/NBK558768/table/ch2.appg.tab1/?report=objectonly" target="object" rid-ob="figobch2appgtab1" class="figpopup">Table 18. Studies excluded from the clinical review</a></p></div><div id="ch2.appg.s2"><h4>G.2. Excluded health economic studies</h4><p>None.</p></div></div><div id="ch2.apph"><h3>Appendix H. Research recommendations</h3><div id="ch2.apph.s1"><h4>H.1. RR1: Does early review of service provision and referral to additional specialist palliative care services improve outcomes for adults with progressive non-cancer disease thought to be entering their last year of life?</h4><p>
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<b>Why this is important:</b>
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</p><p>There is a body of research into the optimal timing of referral to specialist palliative care (SPC) in cancer patients, which generally points to earlier referral leading to better patient-reported outcomes. The committee noted that similar evidence does not exist for patients with a non-cancer diagnosis, for example in patients with progressive organ failure, such as advanced heart failure or dementia. Such patients are typically referred very late to SPC, if at all. There is a need for further research in the latter group, which would compare outcomes from the combination of early identification and specialist palliative care input, versus usual care.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab1"><a href="/books/NBK558768/table/ch2.apph.tab1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab1" rid-ob="figobch2apphtab1"><img class="small-thumb" src="/books/NBK558768/table/ch2.apph.tab1/?report=thumb" src-large="/books/NBK558768/table/ch2.apph.tab1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab1"><a href="/books/NBK558768/table/ch2.apph.tab1/?report=objectonly" target="object" rid-ob="figobch2apphtab1">Table</a></h4><p class="float-caption no_bottom_margin">There is a growing body of research into the benefits of introducing specialist palliative care earlier in the care of advanced cancer patients, but the committee noted that this was not the case for patients with a progressive non-cancer diagnosis who <a href="/books/NBK558768/table/ch2.apph.tab1/?report=objectonly" target="object" rid-ob="figobch2apphtab1">(more...)</a></p></div></div></div></div></div></div><div class="fm-sec"><div><p>Final</p></div><div><p>Evidence review</p><p>Developed by the National Guideline Centre, hosted by the Royal College of Physicians</p></div><div><p><b>Disclaimer</b>: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.</p><p>Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.</p><p>NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the <a href="http://wales.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Welsh Government</a>, <a href="http://www.scotland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Scottish Government</a>, and <a href="http://www.northernireland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Northern Ireland Executive</a>. All NICE guidance is subject to regular review and may be updated or withdrawn.</p></div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2019.</div><div class="small"><span class="label">Bookshelf ID: NBK558768</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32614554" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">32614554</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article><article data-type="table-wrap" id="figobch2tab1"><div id="ch2.tab1" class="table"><h3><span class="label">Table 1</span><span class="title">PICO characteristics of review question</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab1_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><td headers="hd_b_ch2.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adults (aged over 18 or over) with progressive life-limiting conditions thought to be entering the last year of life.</td></tr><tr><th id="hd_b_ch2.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention</th><td headers="hd_b_ch2.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l1"><li id="ch2.lt1" class="half_rhythm"><div>Early referral to (or provision of) palliative care services</div></li><li id="ch2.lt2" class="half_rhythm"><div>Late referral to (or provision of) palliative care services</div></li></ul>
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</td></tr><tr><th id="hd_b_ch2.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparison</th><td headers="hd_b_ch2.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">‘Early’ and ‘late’ as defined by studies</td></tr><tr><th id="hd_b_ch2.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes</th><td headers="hd_b_ch2.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>CRITICAL</p>
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<ul id="ch2.l2"><li id="ch2.lt3" class="half_rhythm"><div>Quality of life (Continuous)</div></li><li id="ch2.lt4" class="half_rhythm"><div>Preferred and actual place of death (Dichotomous)</div></li><li id="ch2.lt5" class="half_rhythm"><div>Preferred and actual place of care (Dichotomous)</div></li></ul>
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<p>IMPORTANT</p>
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<ul id="ch2.l3"><li id="ch2.lt6" class="half_rhythm"><div>Length of survival (Continuous)</div></li><li id="ch2.lt7" class="half_rhythm"><div>Length of stay (Continuous)</div></li><li id="ch2.lt8" class="half_rhythm"><div>Hospitalisation (Dichotomous)</div></li><li id="ch2.lt9" class="half_rhythm"><div>Number of hospital visits (Dichotomous)</div></li><li id="ch2.lt10" class="half_rhythm"><div>Number of visits to accident and emergency (Dichotomous)</div></li><li id="ch2.lt11" class="half_rhythm"><div>Number of unscheduled admissions (Dichotomous)</div></li><li id="ch2.lt12" class="half_rhythm"><div>Use of community services (Dichotomous)</div></li><li id="ch2.lt13" class="half_rhythm"><div>Avoidable/inappropriate admissions to ICU (Dichotomous)</div></li><li id="ch2.lt14" class="half_rhythm"><div>Inappropriate attempts at cardiopulmonary resuscitation (Dichotomous)</div></li><li id="ch2.lt15" class="half_rhythm"><div>Staff satisfaction (Continuous)</div></li><li id="ch2.lt16" class="half_rhythm"><div>Patient/carer reported outcomes (satisfaction) (Continuous)</div></li></ul>
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</td></tr><tr><th id="hd_b_ch2.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch2.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l4"><li id="ch2.lt17" class="half_rhythm"><div>Systematic reviews</div></li><li id="ch2.lt18" class="half_rhythm"><div>RCTs</div></li><li id="ch2.lt19" class="half_rhythm"><div>Non-randomised comparative studies, including before and after studies and interrupted-time-series.</div></li></ul>
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</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2tab2"><div id="ch2.tab2" class="table"><h3><span class="label">Table 2</span><span class="title">Summary of studies included in the evidence review</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study</th><th id="hd_h_ch2.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention and comparison</th><th id="hd_h_ch2.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><th id="hd_h_ch2.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes</th><th id="hd_h_ch2.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comment</th></tr></thead><tbody><tr><td headers="hd_h_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Amano 2015<a class="bibr" href="#ch2.ref3" rid="ch2.ref3"><sup>3</sup></a></td><td headers="hd_h_ch2.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>The palliative care team provided consultation services in both outpatients and inpatients suffering from cancer on the basis of referral from primary responsible physicians. The palliative care team consisted of two palliative physicians and 3 certified palliative care nurses. All patients were followed at least once per week, and the palliative care physician prescribed or gave written recommendations of medication. All patients were monitored continuously until death or transfer to another institution.</p>
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<p>Early (>3 months before death);</p>
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<p>Delayed (<3 months before death)</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Adults and patients who died from cancer or cause related to cancer during the study.</p>
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<p>Follow up: 1 year</p>
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<p>N=265</p>
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<p>Japan</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Number of unscheduled admissions (inpatient hospice utilisation);</p>
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<p>Preferred and actual place of death (Hospital death);</p>
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<p>Number of visits to accident and emergency (People with ≥2 emergency department visits);</p>
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<p>Number of unscheduled admissions (People with ≥2 hospital admissions);</p>
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<p>Hospitalisation (People with >14 days of hospitalisation);</p>
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<p>Avoidable/inappropriate admissions to ICU (People with ICU admission)</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bakitas 2015<a class="bibr" href="#ch2.ref7" rid="ch2.ref7"><sup>7</sup></a></td><td headers="hd_h_ch2.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>ENABLE - includes initial in-person, standardised outpatient palliative care (PC) consultation by a board-certified PC clinician and six structured weekly telephone coaching sessions by an advanced practice nurse using manualised curriculum (Charting Your Course). Session one to three focus on problem solving, symptom management, self-care, identification and coordination of local resources, communication, decision making, and advance care planning. Session four to six focused on outlook, a life review approach that encourages participants to frame advance illness challenges as personal growth opportunities. After the six sessions, monthly follow up calls reinforced prior content and identified new challenges or care coordination issues. Sessions generally lasted 30–45 minutes. Nurse coach training included self-study, review of treatment manuals and scripts, and role play with feedback. Received within 30 days of being informed of an advance cancer diagnosis, or after 3 months.</p>
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<p>Early (within 30 days of diagnosis);</p>
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<p>Delayed (> 3 months of diagnosis)</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Adults with advanced stage solid tumour or hematologic malignancy, oncologist-determined prognosis of 6–24 months, and able to complete baseline questionnaire.</p>
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<p>Aged >18 years</p>
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<p>Follow up: 1 year</p>
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<p>N=207</p>
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<p>USA</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Quality of life (FACIT-PAL) (Functional Assessment of Chronic Illness Therapy - Palliative Care);</p>
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<p>Length of survival;</p>
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<p>Preferred and actual place of death (Deaths at home)</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Hospital use reported as decedents’ rate.</p>
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<p>Insufficient information to extract.</p>
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</td></tr><tr><td headers="hd_h_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hui 2014<a class="bibr" href="#ch2.ref35" rid="ch2.ref35"><sup>35</sup></a></td><td headers="hd_h_ch2.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Referral to palliative care. The Supportive Care Centre operated 5 days per week and saw approximately 25 patients per day. It was staffed by 2 palliative care specialists who were supported by an interdisciplinary team of nurses and a social worker. Patients referred to the palliative care mobile team in the inpatient setting were managed similarly by the same team of palliative care specialists following common clinical pathways.</p>
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<p>3-month cut-off</p>
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<p>Early referral (> 3 months between first palliative care consultation and death);</p>
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<p>Late referral (< 3 months between first palliative care consultation and death)</p>
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<p>6-month cut-off</p>
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<p>Early referral (> 6 months between first palliative care consultation and death);</p>
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<p>Late referral (< 6 months between first palliative care consultation and death)</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>All adult patients in the Houston area who died of advanced cancer between 9/1/2009 and 2/28/2010, who had received a palliative care referral, and had contact with the cancer centre within the last 3 months of life.</p>
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<p>Follow up: 1 year</p>
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<p>N=732</p>
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<p>USA</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Number of unscheduled admissions (People with any number of hospital admission);</p>
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<p>Number of visits to accident and emergency (People with ≥2 emergency room visits);</p>
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<p>Number of unscheduled admissions (People with any hospital admissions);</p>
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<p>Number of hospital visits (People with ≥2 hospital admissions);</p>
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<p>Hospitalisation (People with >14 days of hospitalisation);</p>
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<p>Preferred and actual place of death (Hospital death);</p>
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<p>Preferred and actual place of death (ICU death);</p>
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<p>Avoidable/inappropriate admissions to ICU (People with ICU admission)</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nieder 2016<a class="bibr" href="#ch2.ref64" rid="ch2.ref64"><sup>64</sup></a></td><td headers="hd_h_ch2.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Early referral to (or provision of) palliative care services. Palliative care team involved 3 months before death or earlier.</p>
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<p>Late referral to (or provision of) palliative care services. Palliative Care Team involved only during the last phase of the incurable disease, > 3 months</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>All patients who died from non-small cell lung cancer NSCLC in the uptake area of the Nordland Hospital Trust.</p>
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<p>N=286</p>
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<p>Norway.</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Hospitalisation (hospitalised in last 3 months);Preferred and actual place of death (hospital death);</p>
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<p>Length of survival (median survival)</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Poulose 2013<a class="bibr" href="#ch2.ref68" rid="ch2.ref68"><sup>68</sup></a></td><td headers="hd_h_ch2.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Early referral to (or provision of) palliative care services. Palliative care referral ≥30 days before death.</p>
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<p>Late referral to (or provision of) palliative care services. Palliative care referral >30 days before death.</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Decedents who were referred to and seen by the palliative care specialists.</p>
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<p>N=842</p>
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<p>Singapore</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Preferred and actual place of death (death at home)</p>
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<p>Preferred and actual place of death (inpatient hospice death)</p>
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</td><td headers="hd_h_ch2.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Number of patients referred early or late not provided.</p>
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<p>Male/female data was reported separately.</p>
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<p>Death in hospital was not reported</p>
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</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2tab3"><div id="ch2.tab3" class="table"><h3><span class="label">Table 3</span><span class="title">Early versus Late Referral: data unsuitable for meta-analysis</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab3_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch2.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Outcome</th><th id="hd_h_ch2.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Intervention results</th><th id="hd_h_ch2.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Intervention group (n)</th><th id="hd_h_ch2.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Comparison results</th><th id="hd_h_ch2.tab3_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Comparison group (n)</th><th id="hd_h_ch2.tab3_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th></tr></thead><tbody><tr><td headers="hd_h_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bakitas 2015</td><td headers="hd_h_ch2.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Median survival (months)</td><td headers="hd_h_ch2.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.3</td><td headers="hd_h_ch2.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50</td><td headers="hd_h_ch2.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.8</td><td headers="hd_h_ch2.tab3_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59</td><td headers="hd_h_ch2.tab3_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><td headers="hd_h_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nieder 2016</td><td headers="hd_h_ch2.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Median survival (months)</td><td headers="hd_h_ch2.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_ch2.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22</td><td headers="hd_h_ch2.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.7</td><td headers="hd_h_ch2.tab3_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77</td><td headers="hd_h_ch2.tab3_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very high</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2tab4"><div id="ch2.tab4" class="table"><h3><span class="label">Table 4</span><span class="title">Clinical evidence summary: Early (> 3 months between first palliative care consultation and death) versus late (< 3 months between first palliative care consultation and death) referral to palliative care services</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab4_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch2.tab4_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch2.tab4_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch2.tab4_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch2.tab4_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch2.tab4_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_5" id="hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with <3 months</th><th headers="hd_h_ch2.tab4_1_1_1_5" id="hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with >3 months (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of unscheduled admissions (Inpatient hospice utilisation)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>265</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊕⊝⊝</p>
|
|
<p>LOW<sup>a</sup></p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR1.58 (1.28 to 1.95)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">469 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>272 more per 1000</p>
|
|
<p>(from 131 more to 446 more)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Preferred and actual place of death (Hospital death)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>730</p>
|
|
<p>(3 studies)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup> due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR0.81 (0.71 to 0.93)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">609 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>116 fewer per 1000</p>
|
|
<p>(from 43 fewer to 176 fewer)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of visits to accident and emergency (People with ≥2 emergency room visits)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>631</p>
|
|
<p>(2 studies)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>c</sup> due to imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.62 (0.62 to 1)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">147 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>56 fewer per 1000</p>
|
|
<p>(from 56 fewer to 0 more)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of unscheduled admissions (People with >2 hospital admissions)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>631</p>
|
|
<p>(2 studies)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup> due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.46 (0.27 to 0.8)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">155 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>84 fewer per 1000</p>
|
|
<p>(from 31 fewer to 113 fewer)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Hospitalisation (People with >14 days of hospitalisation)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>631</p>
|
|
<p>(2 studies)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>c</sup> due to imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.77 (0.60 to 0.99)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">398 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>92 fewer per 1000</p>
|
|
<p>(from 4 fewer to 159 fewer)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Avoidable/inappropriate admissions to ICU (People with any ICU admission)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>631</p>
|
|
<p>(2 studies)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup> due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.53 (0.27 to 1.02)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>50 fewer per 1000</p>
|
|
<p>(from 78 fewer to 2 more)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of visits to accident and emergency (People with any number of emergency room visits)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊕⊝⊝</p>
|
|
<p>LOW<sup>a</sup></p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.57 (0.45 to 0.73)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">683 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>294 fewer per 1000</p>
|
|
<p>(from 184 fewer to 376 fewer)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of unscheduled admissions (People with any hospital admission)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup> due to indirectness</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.59 (0.49 to 0.72)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">813 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>333 fewer per 1000</p>
|
|
<p>(from 228 fewer to 415 fewer)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Preferred and actual place of death (ICU death)</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup> due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.62 (0.17 to 2.19)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>15 fewer per 1000</p>
|
|
<p>(from 34 fewer to 48 more)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Hospitalised in last 3 months of life</td><td headers="hd_h_ch2.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>99</p>
|
|
<p>(1 study)</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>c</sup></p>
|
|
<p>due to risk of bias, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab4_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.75 (0.58 to 0.97)</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1 hd_h_ch2.tab4_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">974 per 1000</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_h_ch2.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>244 fewer per 1000</p>
|
|
<p>(from 29 fewer to 409 fewer)</p>
|
|
</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.tab4_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was from studies with observational/non-randomised study design</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.tab4_2"><p class="no_margin">Downgraded by 1 increment because the majority of the evidence had indirect outcomes</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.tab4_3"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab5"><div id="ch2.tab5" class="table"><h3><span class="label">Table 5</span><span class="title">Clinical evidence summary: Early (< 30 days between diagnosis and referral) versus late (> 3 months between diagnosis and referral) referral to palliative care services</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab5_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab5_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch2.tab5_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch2.tab5_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch2.tab5_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch2.tab5_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch2.tab5_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch2.tab5_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch2.tab5_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch2.tab5_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_5" id="hd_h_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Late</th><th headers="hd_h_ch2.tab5_1_1_1_5" id="hd_h_ch2.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Early (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life (FACIT-PAL) Scale from: 0 to 184.</td><td headers="hd_h_ch2.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>155</p>
|
|
<p>(1 study)</p>
|
|
<p>3 months</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊕⊝⊝</p>
|
|
<p>LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to risk of bias, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>The mean quality of life (FACIT-PAL) in the control groups was</p>
|
|
<p>127.2</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>The mean quality of life (facet-pal) in the intervention groups was 2.7 higher</p>
|
|
<p>(1.76 lower to 7.16 higher)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life (FACIT-PAL) Scale from: 0 to 184.</td><td headers="hd_h_ch2.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>155</p>
|
|
<p>(1 study)</p>
|
|
<p>6 months</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊕⊝⊝</p>
|
|
<p>LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to risk of bias, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>The mean quality of life (FACIT-PAL) in the control groups was</p>
|
|
<p>127.2</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>The mean quality of life (facet-pal) in the intervention groups was 2.7 higher</p>
|
|
<p>(1.76 lower to 7.16 higher)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life (FACIT-PAL) Scale from: 0 to 184.</td><td headers="hd_h_ch2.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>155</p>
|
|
<p>(1 study)</p>
|
|
<p>12 months</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊕⊝⊝</p>
|
|
<p>LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to risk of bias, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>The mean quality of life (FACIT-PAL) in the control groups was</p>
|
|
<p>129.1</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>The mean quality of life (facet-pal) in the intervention groups was 0.8 higher</p>
|
|
<p>(3.86 lower to 5.46 higher)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab5_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Preferred and actual place of death (participants who died at home)</td><td headers="hd_h_ch2.tab5_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>110</p>
|
|
<p>(1 study)</p>
|
|
<p>until death</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊕⊝⊝</p>
|
|
<p>LOW<sup>b</sup><sup>,</sup><sup>c</sup> due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab5_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR1.16 (0.80 to 1.68)</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_1 hd_h_ch2.tab5_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">467 per 1000</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_h_ch2.tab5_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>75 more per 1000</p>
|
|
<p>(from 93 fewer to 317 more)</p>
|
|
</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.tab5_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.tab5_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.tab5_3"><p class="no_margin">Downgraded by 1 increment because the majority of the evidence had indirect outcomes</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab6"><div id="ch2.tab6" class="table"><h3><span class="label">Table 6</span><span class="title">Clinical evidence summary: Early (> 6 months between first palliative care consultation and death) versus late (< 6 months between first palliative care consultation and death) referral to palliative care services</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab6_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" headers="hd_h_ch2.tab6_1_1_1_1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" headers="hd_h_ch2.tab6_1_1_1_2" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" headers="hd_h_ch2.tab6_1_1_1_3" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch2.tab6_1_1_1_4" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th><th id="hd_h_ch2.tab6_1_1_1_5" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Anticipated absolute effects</th></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_5" id="hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk with Late</th><th headers="hd_h_ch2.tab6_1_1_1_5" id="hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk difference with Early (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of visits to accident and emergency (People with any number of emergency room visits) (>6 months versus <6 months)</td><td headers="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.66 (0.49 to 0.88)</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1 hd_h_ch2.tab6_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">628 per 1000</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>213 fewer per 1000</p>
|
|
<p>(from 75 fewer to 320 fewer)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of visits to accident and emergency (People with ≥2 emergency room visits) (>6 months versus <6 months)</td><td headers="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.42 (0.19 to 0.92)</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1 hd_h_ch2.tab6_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">211 per 1000</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>123 fewer per 1000</p>
|
|
<p>(from 17 fewer to 171 fewer)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of unscheduled admissions (People with ≥2 hospital admission) (>6 months versus <6 months)</td><td headers="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup></p>
|
|
<p>due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.69 (0.54 to 0.87)</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1 hd_h_ch2.tab6_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">748 per 1000</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>232 fewer per 1000</p>
|
|
<p>(from 97 fewer to 344 fewer)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Number of unscheduled admissions (People with any hospital admission) (>6 months versus <6 months)</td><td headers="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup></p>
|
|
<p>due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.72 (0.37 to 1.38)</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1 hd_h_ch2.tab6_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">185 per 1000</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>52 fewer per 1000</p>
|
|
<p>(from 116 fewer to 70 more)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Hospitalisation (People with >14 days of hospitalisation) (>6 months versus <6 months)</td><td headers="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.65 (0.31 to 1.38)</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1 hd_h_ch2.tab6_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">158 per 1000</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>55 fewer per 1000</p>
|
|
<p>(from 109 fewer to 60 more)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Preferred and actual place of death (Hospital death) (>6 months versus <6 months)</td><td headers="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup></p>
|
|
<p>due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.62 (0.36 to 1.07)</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1 hd_h_ch2.tab6_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">285 per 1000</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>108 fewer per 1000</p>
|
|
<p>(from 183 fewer to 20 more)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Preferred and actual place of death (ICU death) (>6 months versus <6 months)</td><td headers="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup></p>
|
|
<p>due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.8 (0.18 to 3.51)</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1 hd_h_ch2.tab6_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37 per 1000</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>7 fewer per 1000</p>
|
|
<p>(from 30 fewer to 93 more)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Avoidable/inappropriate admissions to ICU (People with any ICU admission) (>6 months versus <6 months)</td><td headers="hd_h_ch2.tab6_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>366</p>
|
|
<p>(1 study)</p>
|
|
<p>1 years</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊕⊝⊝</p>
|
|
<p>LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup></p>
|
|
<p>due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab6_1_1_1_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">RR 0.73 (0.29 to 1.81)</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1 hd_h_ch2.tab6_1_1_2_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101 per 1000</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_h_ch2.tab6_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>27 fewer per 1000</p>
|
|
<p>(from 71 fewer to 82 more)</p>
|
|
</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.tab6_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was from studies with observational/non-randomised study design.</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.tab6_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.tab6_3"><p class="no_margin">Downgraded by 1 increment because the majority of the evidence had indirect outcomes</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab7"><div id="ch2.tab7" class="table"><h3><span class="label">Table 7</span><span class="title">Clinical evidence summary: Early (palliative care provided >30 days before death) versus late (palliative care provided <30 days before death)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab7_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Outcomes</th><th id="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No of Participants (studies) Follow up</th><th id="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality of the evidence (GRADE)</th><th id="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relative effect (95% CI)</th></tr></thead><tbody><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Place of death (males who died at home) (>30 days versus <30 days)</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>842</p>
|
|
<p>(1 study)</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to indirectness</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>OR 2.21</p>
|
|
<p>(1.34 to 3.65)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Place of death (females who died at home) (>30 days versus <30 days)</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>842</p>
|
|
<p>(1 study)</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to indirectness</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>OR 3.33</p>
|
|
<p>(2.07 to 5.36)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Place of death (males who died at inpatient hospice) (>30 days versus <30 days)</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>842</p>
|
|
<p>(1 study)</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup><sup>,</sup><sup>c</sup></p>
|
|
<p>due to indirectness, imprecision</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>OR 2.02</p>
|
|
<p>(1.13 to 3.61)</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Place of death (females who died at inpatient hospice) (>30 days versus <30 days)</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>842</p>
|
|
<p>(1 study)</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⊕⊝⊝⊝</p>
|
|
<p>VERY LOW<sup>a</sup><sup>,</sup><sup>b</sup></p>
|
|
<p>due to indirectness</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>OR 2.69</p>
|
|
<p>(1.55 to 4.67)</p>
|
|
</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.tab7_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was from studies with observational/non-randomised study design</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.tab7_2"><p class="no_margin">Downgraded by 1 increment because the majority of the evidence had indirect outcomes</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.tab7_3"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab8"><div id="ch2.tab8" class="table"><h3><span class="label">Table 8</span><span class="title">Unit costs for NHS Specialist Palliative Care Services</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab8_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Service description</th><th id="hd_h_ch2.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Code</th><th id="hd_h_ch2.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Currency Description</th><th id="hd_h_ch2.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">National Average Unit Cost</th></tr></thead><tbody><tr><th headers="hd_h_ch2.tab8_1_1_1_1 hd_h_ch2.tab8_1_1_1_2 hd_h_ch2.tab8_1_1_1_3 hd_h_ch2.tab8_1_1_1_4" id="hd_b_ch2.tab8_1_1_1_1" colspan="4" rowspan="1" style="text-align:left;vertical-align:top;">Specialist Palliative Care Services in Hospital</th></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Day case and Regular Day/Night</td><td headers="hd_h_ch2.tab8_1_1_1_2 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SD02A</td><td headers="hd_h_ch2.tab8_1_1_1_3 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inpatient Specialist Palliative Care, Same Day, 19 years and over</td><td headers="hd_h_ch2.tab8_1_1_1_4 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£108</td></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inpatient</td><td headers="hd_h_ch2.tab8_1_1_1_2 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SD01A</td><td headers="hd_h_ch2.tab8_1_1_1_3 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inpatient Specialist Palliative Care, 19 years and over</td><td headers="hd_h_ch2.tab8_1_1_1_4 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£396</td></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inpatient</td><td headers="hd_h_ch2.tab8_1_1_1_2 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SD03A</td><td headers="hd_h_ch2.tab8_1_1_1_3 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospital Specialist Palliative Care Support, 19 years and over</td><td headers="hd_h_ch2.tab8_1_1_1_4 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£100</td></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outpatient</td><td headers="hd_h_ch2.tab8_1_1_1_2 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SD04A</td><td headers="hd_h_ch2.tab8_1_1_1_3 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medical Specialist Palliative Care Attendance, 19 years and over</td><td headers="hd_h_ch2.tab8_1_1_1_4 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£136</td></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outpatient</td><td headers="hd_h_ch2.tab8_1_1_1_2 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SD05A</td><td headers="hd_h_ch2.tab8_1_1_1_3 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-Medical Specialist Palliative Care Attendance, 19 years and over</td><td headers="hd_h_ch2.tab8_1_1_1_4 hd_b_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£94</td></tr><tr><th headers="hd_h_ch2.tab8_1_1_1_1 hd_h_ch2.tab8_1_1_1_2 hd_h_ch2.tab8_1_1_1_3 hd_h_ch2.tab8_1_1_1_4" id="hd_b_ch2.tab8_1_1_7_1" colspan="4" rowspan="1" style="text-align:left;vertical-align:top;">Specialist Palliative Care Services in the Community</th></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1 hd_b_ch2.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nursing</td><td headers="hd_h_ch2.tab8_1_1_1_2 hd_b_ch2.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N21AF</td><td headers="hd_h_ch2.tab8_1_1_1_3 hd_b_ch2.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Specialist Nursing, Palliative/Respite Care, Adult, Face to face</td><td headers="hd_h_ch2.tab8_1_1_1_4 hd_b_ch2.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£92</td></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1 hd_b_ch2.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nursing</td><td headers="hd_h_ch2.tab8_1_1_1_2 hd_b_ch2.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N21AN</td><td headers="hd_h_ch2.tab8_1_1_1_3 hd_b_ch2.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Specialist Nursing, Palliative/Respite Care, Adult, Non face to face</td><td headers="hd_h_ch2.tab8_1_1_1_4 hd_b_ch2.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£39</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">Source: NHS reference costs (2015–16)<a class="bibr" href="#ch2.ref20" rid="ch2.ref20"><sup>20</sup></a></p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab9"><div id="ch2.tab9" class="table"><h3><span class="label">Table 9</span><span class="title">Unit costs for Generalist Palliative Care Services</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.tab9/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab9_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Staff Member</th><th id="hd_h_ch2.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Unit Cost of Staff Time<sup>(a)</sup></th></tr></thead><tbody><tr><th headers="hd_h_ch2.tab9_1_1_1_1 hd_h_ch2.tab9_1_1_1_2" id="hd_b_ch2.tab9_1_1_1_1" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Generalist Palliative Care Services in Hospital</th></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospital-based scientific and professional staff</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£24–£77 per working hour (Band 2 – Band 8b)</td></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospital-based nurses</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£86–£130 per hour of patient contact (Band 5 – 7)</td></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospital-based doctors</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£29–£106 (FY1 – Consultant)</td></tr><tr><th headers="hd_h_ch2.tab9_1_1_1_1 hd_h_ch2.tab9_1_1_1_2" id="hd_b_ch2.tab9_1_1_5_1" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Generalist Palliative Care Services in the Community</th></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">General practitioner</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£199 per hour of patient contact</td></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Community-based scientific and professional Staff</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£23–£74 per working hour (Band 2 – Band 8b)</td></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Community nurse</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£22–£73 per working hour (Band 2 – Band 8b)</td></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nurse (GP practice)</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£36 per working hour</td></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Social Worker (adult services)</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£55 per hour of client-related work</td></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Home care worker</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>£24 per hour of face-to-face contact (weekday)</p>
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<p>£27 per hour of face-to-face contact (day-time weekend)</p>
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<p>£25 per hour of face-to-face contact (nigh-time weekday)</p>
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<p>£27 per hour of face-to-face contact (night-time weekend)</p>
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</td></tr><tr><td headers="hd_h_ch2.tab9_1_1_1_1 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family support worker</td><td headers="hd_h_ch2.tab9_1_1_1_2 hd_b_ch2.tab9_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">£52 per hour of client related work</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">Source: Curtis (2016)<a class="bibr" href="#ch2.ref19" rid="ch2.ref19"><sup>19</sup></a></p></div></dd></dl><dl class="bkr_refwrap"><dt>(a)</dt><dd><div id="ch2.tab9_1"><p class="no_margin">Staff costs without qualifications have been reported.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2appatab1"><div id="ch2.appa.tab1" class="table"><h3><span class="label">Table 10</span><span class="title">Review protocol: Early versus late referral to palliative care services</span></h3><div class="caption"><p>Question number: 6</p><p>Relevant section of Scope: Service delivery models for end of life care, including both acute, community and third sector settings covering:
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<ul id="ch2.l5"><li id="ch2.lt20" class="half_rhythm"><div>types of services (supportive and palliative care) provided by generalists and specialists during the course of the last year of life,</div></li><li id="ch2.lt21" class="half_rhythm"><div>who delivers the services and how, multidisciplinary team composition,</div></li><li id="ch2.lt22" class="half_rhythm"><div>timing and review of service provision,</div></li><li id="ch2.lt23" class="half_rhythm"><div>Location of services, for example, place of care,</div></li><li id="ch2.lt24" class="half_rhythm"><div>out of hours, weekend and 24/7 availability of services</div></li></ul></p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appa.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appa.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">ID</th><th id="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Field</th><th id="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Content</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">I</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review question</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">What is the best timing of referral to (or provision of) palliative care services in people thought to be entering their last year of life?</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">II</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Type of review question</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Intervention review.</p>
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<p>A review of health economic evidence related to the same review question was conducted in parallel with this review. For details see the health economic review protocol for this NICE guideline.</p>
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</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">III</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objective of the review</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To identify the best timing of referral to (or provision of) palliative care services in people thought to be entering their last year of life</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IV</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – population / disease / condition / issue / domain</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adults (aged over 18 or over) with progressive life-limiting conditions thought to be entering the last year of life.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">V</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – intervention(s) / exposure(s) / prognostic factor(s)</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l6"><li id="ch2.lt25" class="half_rhythm"><div>Early referral to (or provision of) palliative care services</div></li></ul>
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‘Early’ as defined by studies</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VI</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – comparator(s) / control or reference (gold) standard</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l7"><li id="ch2.lt26" class="half_rhythm"><div>Late referral to (or provision of) palliative care services</div></li></ul>
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‘Late’ as defined by studies</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes and prioritisation</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL
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<ul id="ch2.l8"><li id="ch2.lt27" class="half_rhythm"><div>Quality of life (Continuous)</div></li><li id="ch2.lt28" class="half_rhythm"><div>Preferred and actual place of death (Dichotomous)</div></li><li id="ch2.lt29" class="half_rhythm"><div>Preferred and actual place of care (Dichotomous)</div></li></ul>
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IMPORTANT
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<ul id="ch2.l9"><li id="ch2.lt30" class="half_rhythm"><div>Length of stay (Continuous)</div></li><li id="ch2.lt31" class="half_rhythm"><div>Length of survival (Dichotomous)</div></li><li id="ch2.lt32" class="half_rhythm"><div>Hospitalisation (Dichotomous)</div></li><li id="ch2.lt33" class="half_rhythm"><div>Number of hospital visits (Dichotomous)</div></li><li id="ch2.lt34" class="half_rhythm"><div>Number of visits to accident and emergency (Dichotomous)</div></li><li id="ch2.lt35" class="half_rhythm"><div>Number of unscheduled admissions (Dichotomous)</div></li><li id="ch2.lt36" class="half_rhythm"><div>Use of community services (Dichotomous)</div></li><li id="ch2.lt37" class="half_rhythm"><div>Avoidable/inappropriate admissions to ICU (Dichotomous)</div></li><li id="ch2.lt38" class="half_rhythm"><div>Inappropriate resuscitation (Dichotomous)</div></li><li id="ch2.lt39" class="half_rhythm"><div>Staff satisfaction (Continuous)</div></li><li id="ch2.lt40" class="half_rhythm"><div>Patient/carer reported outcomes (satisfaction) (Continuous)</div></li></ul>
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</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">VIII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – study design</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l10"><li id="ch2.lt41" class="half_rhythm"><div>Systematic reviews</div></li><li id="ch2.lt42" class="half_rhythm"><div>RCTs</div></li><li id="ch2.lt43" class="half_rhythm"><div>Non-randomised comparative studies, including before and after studies.</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IX</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other inclusion exclusion criteria</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l11"><li id="ch2.lt44" class="half_rhythm"><div>Children and young people (17 years or younger) in their last year of life</div></li><li id="ch2.lt45" class="half_rhythm"><div>Studies will only be included if they reported one of more of the outcomes listed above</div></li><li id="ch2.lt46" class="half_rhythm"><div>Descriptive (non-comparative) studies will be excluded</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">X</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Proposed sensitivity / subgroup analysis, or meta-regression</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Subgroup analyses if there is heterogeneity:
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<ul id="ch2.l12"><li id="ch2.lt47" class="half_rhythm"><div>Younger adults (aged 18–25)</div></li><li id="ch2.lt48" class="half_rhythm"><div>Frail elderly</div></li><li id="ch2.lt49" class="half_rhythm"><div>People with dementia</div></li><li id="ch2.lt50" class="half_rhythm"><div>People with hearing loss</div></li><li id="ch2.lt51" class="half_rhythm"><div>People with advanced heart and lung disease</div></li><li id="ch2.lt52" class="half_rhythm"><div>People in prisons</div></li><li id="ch2.lt53" class="half_rhythm"><div>Socioeconomic inequalities (people from lower income brackets)</div></li><li id="ch2.lt54" class="half_rhythm"><div>Homeless people/vulnerably housed</div></li><li id="ch2.lt55" class="half_rhythm"><div>Travellers</div></li><li id="ch2.lt56" class="half_rhythm"><div>People with learning difficulties</div></li><li id="ch2.lt57" class="half_rhythm"><div>People with disabilities</div></li><li id="ch2.lt58" class="half_rhythm"><div>People with mental health problems</div></li><li id="ch2.lt59" class="half_rhythm"><div>Migrant workers</div></li><li id="ch2.lt60" class="half_rhythm"><div>LGBT</div></li><li id="ch2.lt61" class="half_rhythm"><div>People in whom life-prolonging therapies are still an active option</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XI</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Selection process – duplicate screening / selection / analysis</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Quality assurance will be undertaken by a senior research fellow prior to completion.</p>
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<p>Review strategy/other analysis:
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<ul id="ch2.l13"><li id="ch2.lt62" class="half_rhythm"><div>Information on identification tools used as part of a service will be extracted.</div></li><li id="ch2.lt63" class="half_rhythm"><div>Due to the expected complexity of the service models implemented in the studies, studies will be reported separately if necessary. In such case, studies on the populations included in the subgroup list will be highlighted to the Committee and will be considered when making the recommendations</div></li></ul></p>
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</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data management (software)</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l14"><li id="ch2.lt64" class="half_rhythm"><div>Pairwise meta-analyses were performed using Cochrane Review Manager (RevMan5).</div></li><li id="ch2.lt65" class="half_rhythm"><div>GRADEpro was used to assess the quality of evidence for each outcome.</div></li><li id="ch2.lt66" class="half_rhythm"><div>Endnote was used for:
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<ul id="ch2.l15" class="circle"><li id="ch2.lt67" class="half_rhythm"><div>Bibliography, citations, sifting and reference management</div></li></ul></div></li><li id="ch2.lt68" class="half_rhythm"><div>Evibase was used for
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<ul id="ch2.l16" class="circle"><li id="ch2.lt69" class="half_rhythm"><div>Data extraction and quality assessment / critical appraisal</div></li></ul></div></li></ul></td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XIII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Information sources – databases and dates</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Clinical search databases to be used: Medline, Embase, Cochrane Library, Current Nursing and Allied Health Literature (CINAHL), PsycINFO, Healthcare Management Information Consortium (HMIC), Social Policy and Practice (SSP), Applied Social Sciences Index and Abstracts (ASSIA)</p>
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<p>Date: All years</p>
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<p>Health economics search databases to be used: Medline, Embase, NHSEED, HTA</p>
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<p>Date: Medline, Embase from 2014</p>
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<p>NHSEED, HTA – All years</p>
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<p>Language: Restrict to English only</p>
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</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XIV</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Identify if an update</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not applicable.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XV</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Author contacts</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a href="https://www.nice.org.uk/guidance/indevelopment/gidcgwave0799" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.nice.org<wbr style="display:inline-block"></wbr>​.uk/guidance/indevelopment/gidcgwave0799</a>
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</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XVI</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Highlight if amendment to previous protocol</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 4.5 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XVII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy – for one database</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see <a href="#ch2.appb">Appendix B</a></td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XVIII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data collection process – forms / duplicate</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A standardised evidence table format will be used, and published as <a href="#ch2.appa">Appendix A</a> of the evidence report.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XIX</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data items – define all variables to be collected</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see evidence tables in <a href="#ch2.appd">Appendix D</a> (clinical evidence tables) or health economic evidence tables where applicable.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XX</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for assessing bias at outcome / study level</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Standard study checklists were used to critically appraise individual studies. For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a></p>
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<p>The risk of bias across all available evidence was evaluated for each outcome using an adaptation of the ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) toolbox’ developed by the international GRADE working group <a href="http://www.gradeworkinggroup.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.gradeworkinggroup.org/</a></p>
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<p>[Please document any deviations/alternative approach when GRADE isn’t used or if a modified GRADE approach has been used for non-intervention or non-comparative studies.]</p>
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</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXI</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Criteria for quantitative synthesis</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.4 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for quantitative analysis – combining studies and exploring (in)consistency</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the separate <a href="/books/NBK558768/bin/bm1.pdf">Methods</a> report for this guideline.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXIII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-bias assessment – publication bias, selective reporting bias</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/6-Reviewing-research-evidence#assessing-the-quality-of-the-evidence" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</p>
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<p>[Consider exploring publication bias for review questions where it may be more common, such as pharmacological questions, certain disease areas.. Describe any steps taken to mitigate against publication bias, such as examining trial registries.]</p>
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</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXIV</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Confidence in cumulative evidence</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see sections 6.4 and 9.1 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXV</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rationale / context – what is known</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the introduction to the evidence review.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXVI</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Describe contributions of authors and guarantor</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>A multidisciplinary committee</p>
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<p>[<a href="https://www.nice.org.uk/guidance/indevelopment/gidcgwave0799" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.nice.org<wbr style="display:inline-block"></wbr>​.uk/guidance/indevelopment/gidcgwave0799</a>] developed the evidence review. The committee was convened by the National Guideline Centre (NGC) and chaired by Mark Thomas in line with section 3 of <a href="https://www.nice.org.uk/article/pmg20/chapter/1%20Introduction%20and%20overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</p>
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<p>Staff from NGC undertook systematic literature searches, appraised the evidence, conducted meta-analysis and cost-effectiveness analysis where appropriate, and drafted the evidence review in collaboration with the committee. For details please see <a href="https://www.nice.org.uk/article/pmg20/chapter/1-Introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>.</p>
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</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXVII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sources of funding / support</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NGC is funded by NICE and hosted by the Royal College of Physicians.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXVIII</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Name of sponsor</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NGC is funded by NICE and hosted by the Royal College of Physicians.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXIX</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Roles of sponsor</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE funds NGC to develop guidelines for those working in the NHS, public health and social care in England.</td></tr><tr><td headers="hd_h_ch2.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">XXX</td><td headers="hd_h_ch2.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PROSPERO registration number</td><td headers="hd_h_ch2.appa.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not registered</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appatab2"><div id="ch2.appa.tab2" class="table"><h3><span class="label">Table 11</span><span class="title">Health economic review protocol</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appa.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appa.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Review question</th><th id="hd_h_ch2.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">All questions – health economic evidence</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Objectives</b>
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</td><td headers="hd_h_ch2.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">To identify health economic studies relevant to any of the review questions.</td></tr><tr><td headers="hd_h_ch2.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Search criteria</b>
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</td><td headers="hd_h_ch2.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l17"><li id="ch2.lt70" class="half_rhythm"><div>Populations, interventions and comparators must be as specified in the clinical review protocol above.</div></li><li id="ch2.lt71" class="half_rhythm"><div>Studies must be of a relevant health economic study design (cost–utility analysis, cost-effectiveness analysis, cost–benefit analysis, cost–consequences analysis, comparative cost analysis).</div></li><li id="ch2.lt72" class="half_rhythm"><div>Studies must not be a letter, editorial or commentary, or a review of health economic evaluations. (Recent reviews will be ordered although not reviewed. The bibliographies will be checked for relevant studies, which will then be ordered.)</div></li><li id="ch2.lt73" class="half_rhythm"><div>Unpublished reports will not be considered unless submitted as part of a call for evidence.</div></li><li id="ch2.lt74" class="half_rhythm"><div>Studies must be in English.</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Search strategy</b>
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</td><td headers="hd_h_ch2.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A health economic study search will be undertaken using population-specific terms and a health economic study filter – see <a href="#ch2.appg">Appendix G</a>
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<i>[in the Full guideline]</i></td></tr><tr><td headers="hd_h_ch2.appa.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Review strategy</b>
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</td><td headers="hd_h_ch2.appa.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Studies not meeting any of the search criteria above will be excluded. Studies published before 2007, abstract-only studies and studies from non-OECD countries or the USA will also be excluded.</p>
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<p>Each remaining study will be assessed for applicability and methodological limitations using the NICE economic evaluation checklist which can be found in <a href="#ch2.apph">Appendix H</a> of Developing NICE guidelines: the manual (2014).<a class="bibr" href="#ch2.ref63" rid="ch2.ref63"><sup>63</sup></a></p>
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<p><b>Inclusion and exclusion criteria</b>
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<ul id="ch2.l18"><li id="ch2.lt75" class="half_rhythm"><div>If a study is rated as both ‘Directly applicable’ and with ‘Minor limitations’ then it will be included in the guideline. A health economic evidence table will be completed and it will be included in the health economic evidence profile.</div></li><li id="ch2.lt76" class="half_rhythm"><div>If a study is rated as either ‘Not applicable’ or with ‘Very serious limitations’ then it will usually be excluded from the guideline. If it is excluded then a health economic evidence table will not be completed and it will not be included in the health economic evidence profile.</div></li><li id="ch2.lt77" class="half_rhythm"><div>If a study is rated as ‘Partially applicable’, with ‘Potentially serious limitations’ or both then there is discretion over whether it should be included.</div></li></ul></p>
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<p>
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<b>Where there is discretion</b>
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</p>
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<p>The health economist will make a decision based on the relative applicability and quality of the available evidence for that question, in discussion with the guideline committee if required. The ultimate aim is to include health economic studies that are helpful for decision-making in the context of the guideline and the current NHS setting. If several studies are considered of sufficiently high applicability and methodological quality that they could all be included, then the health economist, in discussion with the committee if required, may decide to include only the most applicable studies and to selectively exclude the remaining studies. All studies excluded on the basis of applicability or methodological limitations will be listed with explanation as excluded health economic studies in Appendix M. The health economist will be guided by the following hierarchies.</p>
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<p><i>Setting:</i>
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<ul id="ch2.l19"><li id="ch2.lt78" class="half_rhythm"><div>UK NHS (most applicable).</div></li><li id="ch2.lt79" class="half_rhythm"><div>OECD countries with predominantly public health insurance systems (for example, France, Germany, Sweden).</div></li><li id="ch2.lt80" class="half_rhythm"><div>OECD countries with predominantly private health insurance systems (for example, Switzerland).</div></li><li id="ch2.lt81" class="half_rhythm"><div>Studies set in non-OECD countries or in the USA will be excluded before being assessed for applicability and methodological limitations.</div></li></ul></p>
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<p><i>Health economic study type:</i>
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<ul id="ch2.l20"><li id="ch2.lt82" class="half_rhythm"><div>Cost–utility analysis (most applicable).</div></li><li id="ch2.lt83" class="half_rhythm"><div>Other type of full economic evaluation (cost–benefit analysis, cost-effectiveness analysis, cost–consequences analysis).</div></li><li id="ch2.lt84" class="half_rhythm"><div>Comparative cost analysis.</div></li><li id="ch2.lt85" class="half_rhythm"><div>Non-comparative cost analyses including cost-of-illness studies will be excluded before being assessed for applicability and methodological limitations.</div></li></ul></p>
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<p><i>Year of analysis:</i>
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<ul id="ch2.l21"><li id="ch2.lt86" class="half_rhythm"><div>The more recent the study, the more applicable it will be.</div></li><li id="ch2.lt87" class="half_rhythm"><div>Studies published in 2007 or later but that depend on unit costs and resource data entirely or predominantly from before 2007 will be rated as ‘Not applicable’.</div></li><li id="ch2.lt88" class="half_rhythm"><div>Studies published before 2007 will be excluded before being assessed for applicability and methodological limitations.</div></li></ul></p>
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<p><i>Quality and relevance of effectiveness data used in the health economic analysis:</i>
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<ul id="ch2.l22"><li id="ch2.lt89" class="half_rhythm"><div>The more closely the clinical effectiveness data used in the health economic analysis match with the outcomes of the studies included in the clinical review the more useful the analysis will be for decision-making in the guideline.</div></li></ul></p>
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</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab1"><div id="ch2.appb.tab1" class="table"><h3><span class="label">Table 12</span><span class="title">Database date parameters and filters used</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Database</th><th id="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dates searched</th><th id="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Search filter used</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medline (Ovid)</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1946 – 04 January 2019</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusions</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase (Ovid)</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1974 – 04 January 2019</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusions</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The Cochrane Library (Wiley)</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Cochrane Reviews to Issue 1 of 12, January 2019</p>
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<p>CENTRAL to Issue 1 of 12, January 2019</p>
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<p>DARE, and NHSEED to Issue 2 of 4 2015</p>
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<p>HTA to Issue 4 of 4 2016</p>
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</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CINAHL, Current Nursing and Allied Health Literature (EBSCO)</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inception – 04 January 2019</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Limiters - English Language; Exclude MEDLINE records; Publication Type: Clinical Trial, Journal Article, Meta Analysis, Randomized Controlled Trial, Systematic Review: Age Groups: All Adult; Language: English</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PsycINFO (ProQuest)</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inception – 04 January 2019</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study type</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HMIC. Healthcare Management Information Consortium (Ovid)</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1979 – 04 January 2019</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusions</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SPP, Social Policy and Practice</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1981 – 04 January 2019</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study types</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ASSIA, Applied Social Sciences Index and Abstracts (ProQuest)</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1987 – 04 January 2019</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab2"><div id="ch2.appb.tab2" class="table"><h3><span class="title">Medline (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab2_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Palliative care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Terminal care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospice care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 (care* or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nursing Homes/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Respite Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospices/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Advance Care Planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Continuity of Patient Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Physician-Patient Relations/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Long-Term Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Delivery of Health Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–21</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Terminally Ill/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 ill*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/23–32</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22 and 33</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">news/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp historical article/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">comment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/35–43</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43 not 44</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animals, Laboratory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experimentation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Models, Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/45–51</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34 not 52</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53 not 54</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 55 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“referral and consultation”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(referral* or referred or referring or refer or refers or consult*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(recommend* or direct*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/57–59</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(commission* adj2 (support* or service* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((service* or program* or co-ordinat* or co ordinat* or coordinat*) adj2 (model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Critical Pathways/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((critical or clinic* or service* or care) adj2 path*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Patient Care Bundles/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(care adj2 (bundle* or service* or package* or standard*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/61–66</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(assess* or criteria* or predict* or recogni* or identif* or refer*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56 and 67 and 68</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">gold standard*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56 and 70</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(amber adj2 bundle).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69 or 71 or 72</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">patient care team/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">interdisciplinary communication/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((interdisciplin* or inter-disciplin* or interprofession* or inter-profession* or multidisciplin* or multi-disciplin* or multi-profession* or multiprofession* or transprofession* or trans-profession*) adj2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((integrat* or network*) adj2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(key adj2 work*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) adj2 (lead or leader or leads or facilitat*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) adj1 profession*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Case Management/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(case adj2 manage*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(co-ordinator* or coordinator* or coordinate* or co-ordinate*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/74–83</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">interdisciplinary communication/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Communication Barriers/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(communicat* or discuss* or speak* or talk* or convers* or contact).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((handover or hand over or share or shared or sharing or transfer*) adj3 information*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(followup or follow up).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(palliativ* adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/85–90</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56 and 84 and 91</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Social Welfare/ec, ed, es, eh, ma, st, sn, td [Economics, Education, Ethics, Ethnology, Manpower, Standards, Statistics & Numerical Data, Trends]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Charities/ec, ed, es, ma, mt, og, st, sn, sd, td, ut [Economics, Education, Ethics, Manpower, Methods, Organization & Administration, Standards, Statistics & Numerical Data, Supply & Distribution, Trends, Utilization]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Home Care Services/ec, ed, es, ma, mt, og, st, sn, sd, td, ut [Economics, Education, Ethics, Manpower, Methods, Organization & Administration, Standards, Statistics & Numerical Data, Supply & Distribution, Trends, Utilization]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Community Health Nursing/ec, ed, es, ma, mt, og, st, sn, sd, td, ut [Economics, Education, Ethics, Manpower, Methods, Organization & Administration, Standards, Statistics & Numerical Data, Supply & Distribution, Trends, Utilization]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Telemedicine/ec, es, ma, mt, og, st, sn, td, ut [Economics, Ethics, Manpower, Methods, Organization & Administration, Standards, Statistics & Numerical Data, Trends, Utilization]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp remote consultation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*telemedicine/ or *telepathology/ or *teleradiology/ or *telerehabilitation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">100.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(telemedicine or tele medicine or telehealth or tele health or virtual hospital* or helpline* or help line* or rapid response team* or telepathology or teleradiology or telerehabilitatio).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((tele* or remote) adj2 consult*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">102.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mobile Health Units/ec, es, ma, og, st, sn, sd, td, ut [Economics, Ethics, Manpower, Organization & Administration, Standards, Statistics & Numerical Data, Supply & Distribution, Trends, Utilization]</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">103.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(mobile adj2 (health or care) adj2 unit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">104.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospital-based home care or HBHC or hospital-based hospice care or acute hospital care).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">105.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospital adj3 (domicil* or home)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">106.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">home hospitali*ation.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Home Care Agencies/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">108.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(social adj (welfare or care)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">109.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nurs* adj4 (home-visit* or home visit* or home-based or home based)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">110.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((district* or communit* or home or visit*) adj nurs*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">111.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(community adj2 (health care or healthcare or nursing or nurse*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">112.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((hospitali*ation* or admission* or readmission* or admit*) adj3 (reduc* or avoid* or prevent* or inappropiate or increase* or risk*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">113.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/93–112</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">114.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Continuity of Patient Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">115.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Aftercare/ or *Patient discharge/ or *Patient handoff/ or *Patient transfer/ or *Transitional care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">116.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Patient Discharge Summaries/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">117.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((patient* or person* or people or nursing* or clinic*) adj (discharg* or handover* or hand* over* or handoff* or hand off* or signout* or sign* out* or signover* or sign* over*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">118.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or caring or serv*) adj2 (continu* or change* or transition* or transfer*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">119.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(discharg* adj2 (facilitat* or rapid* or pathway* or path way* or plan* or program*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">120.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/114–119</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">121.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">122.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">123.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/121–122</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">124.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Caregiver/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">125.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Spouse/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">126.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Family/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">127.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">128.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/124–127</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">129.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((replacement or break* or holiday* or respite) adj3 (care* or service*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">130.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((communit* or support* or psychosocial* or psycholog*) adj3 (service* or group* or system*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">131.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((group* or support* or psychosocial* or psycholog*) adj3 (selfhelp or self help or therap*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">132.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((psychosocial* or psycholog*) adj2 support*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">133.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Self-Help/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">134.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Social support/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">135.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Counseling/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">136.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(counseling or counselling*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">137.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(buddy* or buddies).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">138.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((health* or medical*) adj2 check*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">139.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*) adj3 (education or educate or educating or information or literature or leaflet* or booklet* or pamphlet* or website* or knowledge)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">140.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/129–139</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">141.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56 and 128 and 140</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">142.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56 and (60 or 84 or 113 or 120 or 123)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">143.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73 or 92 or 141 or 142</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab3"><div id="ch2.appb.tab3" class="table"><h3><span class="title">Embase (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab3_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Palliative therapy/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Terminal care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Hospice care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 (care* or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Nursing home/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Respite Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Hospice/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Doctor patient relation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Long term care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Health care delivery/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–21</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Terminally ill patient/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 ill*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/23–32</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22 and 33</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/35–39</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40 not 41</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/42–49</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34 not 50</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51 not 52</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 53 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp patient referral/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(referral* or referred or referring or refer or refers or consult*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(recommend* or direct*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/55–57</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54 and 58</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(commission* adj2 (support* or service* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((service* or program* or co-ordinat* or co ordinat* or coordinat*) adj2 (model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Clinical Pathway/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((critical or clinic* or service* or care) adj2 path*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Care Bundle/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(care adj2 (bundle* or service* or package* or standard*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/60–65</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(assess* or criteria* or predict* or recogni* or identif* or refer*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54 and 66 and 67</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">gold standard*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54 and 69</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(amber adj2 bundle).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68 or 70 or 71</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">interdisciplinary communication/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">patient care team*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((interdisciplin* or inter-disciplin* or interprofession* or inter-profession* or multidisciplin* or multi-disciplin* or multi-profession* or multiprofession* or transprofession* or trans-profession*) adj2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((integrat* or network*) adj2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(key adj2 work*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) adj2 (lead or leader or leads or facilitat*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) adj1 profession*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Case Management/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(case adj2 manage*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(co-ordinator* or coordinator* or coordinate* or co-ordinate*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/73–82</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">interdisciplinary communication/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(communicat* or discuss* or speak* or talk* or convers* or contact).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((handover or hand over or share or shared or sharing or transfer*) adj3 information*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(followup or follow up).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(palliativ* adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/84–88</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54 and 83 and 89</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*social welfare/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*community health nursing/ or *community care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*senior center/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*telemedicine/ or *telehealth/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*teleconsultation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(telehealth or tele health or virtual hospital* or helpline* or help line* or rapid response team* or mobile health unit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*home care/ or *home health agency/ or *home monitoring/ or *home oxygen therapy/ or *home physiotherapy/ or *home rehabilitation/ or *home respiratory care/ or *respite care/ or *visiting nursing service/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*health care personnel/ or *health auxiliary/ or *nursing home personnel/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(telemedicine or tele medicine or telehealth or tele health or virtual hospital* or helpline* or help line* or rapid response team* or telepathology or teleradiology or telerehabilitatio).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">100.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((tele* or remote) adj2 consult*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(mobile adj2 (health or care) adj2 unit*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">102.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospital-based home care or HBHC or hospital-based hospice care or acute hospital care).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">103.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospital adj3 (domicil* or home)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">104.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">home hospitali*ation.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">105.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(social adj (welfare or care)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">106.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nurs* adj4 (home-visit* or home visit* or home-based or home based)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((district* or communit* or home or visit*) adj nurs*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">108.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(community adj2 (health care or healthcare or nursing or nurse*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">109.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((hospitali*ation* or admission* or readmission* or admit*) adj3 (reduc* or avoid* or prevent* or inappropiate or increase* or risk*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">110.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/91–109</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">111.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*patient care/ or *case management/ or *patient care planning/ or *rapid response team/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">112.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*aftercare/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">113.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*hospital discharge/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">114.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*clinical handover/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">115.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*transitional care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">116.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">117.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*medical record/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">118.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((patient* or person* or people or nursing* or clinic*) adj (discharg* or handover* or hand* over* or handoff* or hand off* or signout* or sign* out* or signover* or sign* over*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">119.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or caring or serv*) adj2 (continu* or change* or transition* or transfer*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">120.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(discharg* adj2 (facilitat* or rapid* or pathway* or path way* or plan* or program*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">121.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/111–120</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">122.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">123.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">124.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/122–123</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">125.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Caregiver/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">126.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Spouse/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">127.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Family/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">128.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">129.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Or/125–128</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">130.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((replacement or break* or holiday* or respite) adj3 (care* or service*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">131.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((communit* or support* or psychosocial* or psycholog*) adj3 (service* or group* or system*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">132.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((group* or support* or psychosocial* or psycholog*) adj3 (selfhelp or self help or therap*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">133.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((psychosocial* or psycholog*) adj2 support*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">134.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Self-Help/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">135.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Social support/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">136.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Counseling/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">137.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(counseling or counselling*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">138.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(buddy* or buddies).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">139.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((health* or medical*) adj2 check*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">140.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*) adj3 (education or educate or educating or information or literature or leaflet* or booklet* or pamphlet* or website* or knowledge)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">141.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/130–140</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">142.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54 and 129 and 141</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">143.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54 and (83 or 110 or 121 or 124)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">144.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59 or 72 or 90 or 142 or 143</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab4"><div id="ch2.appb.tab4" class="table"><h3><span class="title">Cochrane Library (Wiley) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab4_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Palliative Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Terminal Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Hospice Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) near/2 (care* or caring)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Nursing Homes] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) near/2 (home or homes)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Respite Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) near/2 (care or caring)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Hospices] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Advance Care Planning] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* near/2 (plan* or decision* or directive*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Care Planning] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Continuity of Patient Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) near/3 (care or caring) near/3 (continu* or plan*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Physician-Patient Relations] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Long-Term Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Delivery of Health Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) near/2 (care or caring)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #1–#21)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Terminally Ill] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) near/2 ill*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) near (phase* or stage*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Attitude to Death] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* near/3 (death* or dying*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end near/2 life):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) near/2 (year or month*) near/2 life):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) near/2 (patient* or person* or people)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #24–#32)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#22 and #33</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Referral and Consultation] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(referral* or referred or referring or refer or refers or consult*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(recommend* or direct*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #34–#36)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#34 and #38</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(commission* near/2 (support* or service* or model*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((service* or program* or co-ordinat* or co ordinat* or coordinat*) near/2 (model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Critical Pathways] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((critical or clinic* or service* or care) near/2 path*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Care Bundles] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(care near/2 (bundle* or service* or package* or standard*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #40–#45)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(assess* or criteria* or predict* or recogni* or identif* or refer*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#34 and #46 and #47</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">gold standard*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#34 and #49</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(amber near/2 bundle):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#48 or #50 or #51</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Care Team] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Interdisciplinary Communication] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((interdisciplin* or inter-disciplin* or interprofession* or inter-profession* or multidisciplin* or multi-disciplin* or multi-profession* or multiprofession* or transprofession* or trans-profession*) near/2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)) or MDT or IDT):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((integrat* or network*) near/2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(key near/2 work*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) near/2 (lead or leader or leads or facilitat*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((healthcare or care) near/1 profession*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Case Management] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(case near/2 manage*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(co-ordinator* or coordinator* or coordinate* or co-ordinate*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #53–#62)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Interdisciplinary Communication] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Communication Barriers] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(communicat* or discuss* or speak* or talk* or convers* or contact):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((handover or hand over or share or shared or sharing or transfer*) near/3 information*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(followup or follow up):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(palliativ* near/2 (care or caring)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #64–#69)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34 and 63 and 69</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Social Welfare] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Charities] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Adult Day Care Centers] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Community Health Nursing] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Home Care Services] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Senior Centers] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Telemedicine] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Remote Consultation] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(telehealth or tele health or virtual hospital* or helpline* or help line* or rapid response team*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Mobile Health Units] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((community based or community dwelling home or rural) near/3 (care or health care or healthcare)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospital-based home care or HBHC or hospital-based hospice care or acute hospital care):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((hospitali*ation* or admission* or readmission* or admit*) near/3 (reduc* or avoid* or prevent* or inappropiate or increase* or risk*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(home based versus hospital based):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospital near/3 (domicil* or home)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(home hospitali*ation):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Home Care Services, Hospital-Based] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Home Health Nursing] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Homemaker Services] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Home Care Agencies] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Home Health Aides] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(social care):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Nurses, Community Health] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nurs* near/4 (home-visit* or home visit* or home-based or home based)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((district* or communit* or home or visit*) near nurs*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(Or #72–#96)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Continuity of Patient Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Aftercare] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#100.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Discharge] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#101.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Handoff] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#102.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Transfer] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#103.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Transitional Care] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#104.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Patient Discharge Summaries] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#105.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((patient* or person* or people or nursing* or clinic*) near (discharg* or handover* or hand* over* or handoff* or hand off* or signout* or sign* out* or signover* or sign* over*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#106.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or caring or serv*) near/2 (continu* or change* or transition* or transfer*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#107.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(discharg* near/2 (facilitat* or rapid* or pathway* or path way* or plan* or program*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#108.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #98–#107)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#109.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Advance Care Planning] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#110.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* near/2 (plan* or decision* or directive*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#111.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#112.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #109–#111)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#113.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Caregivers] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#114.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Spouses] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#115.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Family] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#116.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#117.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #113–#116)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#118.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((replacement or break* or holiday* or respite) near/3 (care* or service*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#119.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((communit* or support* or psychosocial* or psycholog*) near/3 (service* or group* or system*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#120.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((group* or support* or psychosocial* or psycholog*) near/3 (selfhelp or self help or therap*)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#121.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((psychosocial* or psycholog*) near/2 support*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#122.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Self-Help Groups] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#123.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Social Support] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#124.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Counseling] this term only</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#125.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(counseling or counselling*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#126.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(buddy* or buddies):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#127.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health or medical*) near/3 check*:ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#128.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(spouse* or wife or wives or husband* or carer* or caregiver* or care giver* or significant other* or friend* or partner* or family or families or individual* or sibling* or brother* or sister* or relative or relatives or mothers* or daughters* or father* or son or sons or uncle* or aunt* or grand mother* or grandmother* or grandfather* or grand father* or aunt* or uncle* or cousin* or niece* or nephew*) near/3 (education or educate or educating or information or literature or leaflet* or booklet* or pamphlet* or website* or knowledge):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#129.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(or #118–#128)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#130.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#34 and #117 and #129</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#131.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#34 and (#63 or #97 or #108 or #112)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#132.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#39 or #52 or #71 or #130 or #131</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab5"><div id="ch2.appb.tab5" class="table"><h3><span class="title">CINAHL (EBSCO) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab5_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Palliative care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Terminal care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Hospice care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI palliat* OR AB palliat*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MW Terminally ill</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( terminal* or long term or longterm ) AND TI ( care* or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( terminal* or long term or longterm ) AND AB ( care* or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( dying or terminal ) AND TI ( phase* or stage* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( dying or terminal ) AND AB ( phase* or stage* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI life limit* OR AB life limit*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Nursing homes</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( care or nursing ) AND TI ( home or homes )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( care or nursing ) AND AB ( home or homes )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Respite care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( respite or day ) AND TI ( care or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( respite or day ) AND AB ( care or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Hospices</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI Hospice* OR AB Hospice*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Patient Care Plans”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Continuity of Patient Care”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( advance* or patient* ) AND TI ( care or caring ) AND TI ( continu* or plan* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( advance* or patient* ) AND AB ( care or caring ) AND AB ( continu* or plan* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Attitude to Death</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI attitude* AND TI ( death* or dying )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB attitude* AND AB ( death* or dying )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Physician-Patient Relations</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Long Term Care”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Health Care Delivery”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI end AND TI life OR AB end AND AB life</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI EOLC OR AB EOLC</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( last or final ) AND TI ( year or month ) AND TI life</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( last or final ) AND AB ( year or month ) AND AB life</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( dying or death ) AND TI ( patient* or person* or people )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( dying or death ) AND AB ( patient* or person* or people )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( terminal* or long term or longterm ) AND TI (ill* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( terminal* or long term or longterm ) AND AB (ill*)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( dying or death ) AND TI ( care or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( dying or death ) AND AB ( care or caring )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S1 OR S2 OR S3 OR S4 OR S6 OR S7 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S26 OR S27 OR S28 OR S37 OR S38</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S5 OR S8 OR S9 OR S10 OR S23 OR S24 OR S25 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S39 AND S40</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Referral and Consultation+”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( referral* or referred or referring or refer or refers or consult* ) OR AB ( referral* or referred or referring or refer or refers or consult* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( recommend* or direct* ) OR AB ( recommend* or direct* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S42 OR S43 OR S44</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S41 AND S45</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI commission* AND TI ( (support* or service* or model*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB commission* AND AB ( (support* or service* or model*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( service* or program* or co-ordinat* or co ordinat* or coordinat* ) AND TI ( model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( service* or program* or co-ordinat* or co ordinat* or coordinat* ) AND AB ( model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( critical or clinic* or service* or care ) AND TI path*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( critical or clinic* or service* or care ) AND AB path*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI care AND TI ( bundle* or service* or package* or standard* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB care AND AB ( bundle* or service* or package* or standard* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S47 OR S48 OR 49 OR S50 OR S51 OR S52 OR S53 OR S54</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( assess* or criteria* or predict* or recogni* or identif* or refer* ) OR AB ( assess* or criteria* or predict* or recogni* or identif* or refer* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S41 AND S55 AND S56</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI gold standard* OR AB gold standard*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S41 AND S58</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI amber AND TI bundle</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB amber AND AB bundle</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S60 OR S61</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S57 OR S59 OR 62</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Multidisciplinary Care Team+”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MDT OR IDT</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((interdisciplin* or inter-disciplin* or interprofession* or inter-profession* or multidisciplin* or multi-disciplin* or multi-profession* or multiprofession* or transprofession* or trans-profession*) n2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((integrat* or network*) n2 (team* or staff* or meeting* or manag* or appointment* or system* or program* or practic* or advic* or advis* or caring or intervention* or ward* or round* or panel* or forum* or fora or communicat* or collaborat* or relat*))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI (key n2 work*) OR AB (key n2 work*)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( ((healthcare or care) n2 (lead or leader or leads or facilitat*)) ) OR AB ( ((healthcare or care) n2 (lead or leader or leads or facilitat*)) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( ((healthcare or care) n1 profession*) ) OR AB ( ((healthcare or care) n1 profession*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Case Management</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI (case n2 manage*) OR AB (case n2 manage*)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( (co-ordinator* or coordinator* or coordinate* or co-ordinate*)*) ) OR AB ( (coordinator* or coordinator* or coordinate* or co-ordinate*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S64 OR S65 OR S66 OR S67 OR S68 OR S69 OR S70 OR S71 OR S72 OR S73</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Interdisciplinary Communication] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [Communication Barriers] explode all trees</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(communicat* or discuss* or speak* or talk* or convers* or contact):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((handover or hand over or share or shared or sharing or transfer*) near/3 information*):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(followup or follow up):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(palliativ* near/2 (care or caring)):ti,ab</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S75 OR S76 OR S77 OR S78 OR S79 OR S80</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S41 AND S74 AND S81</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Social Welfare”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Charities”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Adult Day Center (Saba CCC)”) OR (MM “Housing for the Elderly”) OR (MM “Older Adult Care (Saba CCC)”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Community Health Nursing+”) OR (MM “Community Health Centers”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Home Health Care+”) OR (MM “Home Health Aides”) OR (MM “Home Health Care Information Systems”) OR (MM “Home Health Aide Service (Saba CCC)”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Housing for the Elderly”) OR (MM “Rural Health Centers”) OR (MM “Community Health Centers”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Telemedicine+”) OR (MH “Telehealth+”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Remote Consultation”) OR (MM “Telephone Consultation (Iowa NIC)”) OR (MM “Services for Australian Rural and Remote Allied Health”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">telehealth or tele health or virtual hospital* or helpline* or help line* or rapid response team* or senior center*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Rural Health Personnel”) OR (MM “Mobile Health Units”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">remote consultation</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((community based or community dwelling home or rural) n3 (care or health care or healthcare))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospital-based home care or HBHC or hospital-based hospice care or acute hospital care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((hospitali?ation* or admission* or readmission* or admit*) n3 (reduc* or avoid* or prevent* or inappropiate or increase* or risk*))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">home based versus hospital based</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospital n3 (domicil* or home))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">home hospitali?ation</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S100.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">home care service*</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S101.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Home Health Agencies”) OR (MM “Nursing Home Personnel”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S102.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Homemaker Services”) OR (MM “Health Services for the Aged”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S103.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MH “Home Health Care+”) OR (MM “Home Care Equipment and Supplies”) OR (MH “Nursing Homes”) OR (MM “National Association for Home Care & Hospice”) OR (MM “Nursing Home Patients”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S104.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">social care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S105.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Hospitals, Community”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S106.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Home Nursing”) OR (MM “Home Nursing, Professional”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S107.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nurs* n4 (home-visit* or home visit* or home-based or home based))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S108.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((district* or communit* or home or visit*) n nurs*)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S109.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S83 OR S84 OR S85 OR S86 OR S87 OR S88 OR S89 OR S90 OR S91 OR S92 OR S93 OR S94 OR S95 OR S96 OR S97 OR S98 OR S99 OR S100 OR S101 OR S102 OR S103 OR S104 OR S105 OR S106 OR S107 OR S108</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S110.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MH Continuity of Patient Care OR MH Aftercare OR MH Patient discharge OR MH Patient handoff OR MH Patient transfer OR MH Transitional care</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S111.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(MM “Discharge Planning”) OR (MM “Patient Discharge Summaries”)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S112.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( ((patient* or person* or people or nursing* or clinic*) ) AND TX ( (discharg* or handover* or hand* over* or handoff* or hand off* or signout* or sign* out* or signover* or sign* over*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S113.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( ((patient* or person* or people or nursing* or clinic*) ) AND AB ( (discharg* or handover* or hand* over* or handoff* or hand off* or signout* or sign* out* or signover* or sign* over*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S114.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB ( (care or caring or serv*) ) AND AB ( (continu* or change* or transition* or transfer*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S115.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI ( (care or caring or serv*) ) AND TI ( (continu* or change* or transition* or transfer*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S116.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI discharg* AND TI ( facilitat* or rapid* or pathway* or path way* or plan* or program*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S117.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB discharg* AND AB ( facilitat* or rapid* or pathway* or path way* or plan* or program*) )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S118.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S110 OR S111 OR S112 OR S113 OR S114 OR S115 OR S116 OR S117</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S119.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TI advance* AND TI ( plan* or decision* or directive* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S120.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">AB advance* AND AB ( plan* or decision* or directive* )</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S121.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S119 OR S120</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S122.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S41 AND (S74 OR S109 OR S118 OR S121)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S123.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">S46 OR S63 OR S82 OR S122</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab6"><div id="ch2.appb.tab6" class="table"><h3><span class="title">PsycINFO (ProQuest) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab6_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(ti,ab(commission* NEAR/2 (support* OR service* OR model*)) OR ((service* OR program* OR co-ordinat* OR coordinat*) NEAR/2 (model* OR deliver* OR strateg* OR support* OR access* OR method* OR system* OR policies OR policy OR availab*))) AND (SU.EXACT(“Palliative Care”) OR SU.EXACT(“Terminally Ill Patients”) OR SU.EXACT(“Hospice”) OR ti,ab(palliat*) OR ti,ab((terminal* OR long-term OR longterm) NEAR/2 (care* OR caring OR ill*)) OR ti,ab((dying OR terminal) NEAR/1 (phase* OR stage*)) OR ti,ab(life-limit*) OR SU.EXACT(“Nursing Homes”) OR ti,ab((care OR nursing) NEAR/2 (home OR homes)) OR SU.EXACT(“Respite Care”) OR ti,ab((respite OR day) NEAR/2 (care OR caring)) OR ti,ab(hospice*) OR MJSUB.EXACT(“Treatment Planning”) OR MJSUB.EXACT(“Continuum of Care”) OR ti,ab((advance* OR patient*) NEAR/3 (care OR caring) NEAR/3 (continu* OR plan*)) OR MJSUB.EXACT(“Long Term Care”) OR ti,ab(attitude* NEAR/3 (death* OR dying*)) OR ti,ab(end NEAR/2 life) OR ti,ab(EOLC) OR ti,ab((last OR final) NEAR/2 (year OR month*) NEAR/2 life) OR ti,ab((dying OR death) NEAR/2 (patient* OR person* OR people OR care OR caring)))</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adolescence (13–17 Yrs), Adulthood (18 Yrs & Older), Aged (65 Yrs & Older), Middle Age (40–64 Yrs), Thirties (30–39 Yrs), Very Old (85 Yrs & Older), Young Adulthood (1829 Yrs)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 and 2</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Conference Proceedings, Journal Article, Peer Reviewed Journal</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 and 4</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab7"><div id="ch2.appb.tab7" class="table"><h3><span class="title">HMIC (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab7_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp End of life care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(terminal* adj ill*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/2–8</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp Paediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp older people/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 not 10</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 11 to English</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 12 to (audiovis or book or chapter dh helmis or circular or microfiche dh helmis or multimedias or website)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 12 to (audiocass or books or cdrom or chapter or dept pubs or diskettes or folio pamp or “map” or marc or microfiche or multimedia or pamphlet or parly or press or press rel or thesis or trustdoc or video or videos or website)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 or 14</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12 not 15</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">euthanasia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">euthanasia.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17 or 18</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 not 19</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab8"><div id="ch2.appb.tab8" class="table"><h3><span class="title">SPP (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab8_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nursing adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(terminal* adj2 ill*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(respite adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–15</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(child* or infant*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(adult* or adolescent*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17 not 18</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 not 19</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 20 to (journal or journal article or online resource or online report or report)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab9"><div id="ch2.appb.tab9" class="table"><h3><span class="title">ASSIA (ProQuest) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab9/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab9_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab. ((ti,ab(commission* N/2 (support* or service* or model*)) OR ti,ab((service* or program* or co-ordinat* or coordinat*) N/2 (model* or deliver* or strateg* or support* or access* or method* or system* or policies or policy or availab*))) AND ((SU.EXACT(“Care” OR “Clinical nursing” OR “Community homes” OR “Community nursery nursing” OR “Community nursing” OR “Compassionate care” OR “Continuing care” OR “District nursing” OR “Family centred care” OR “Geriatric wards” OR “Group care” OR “Health visiting” OR “Home care” OR “Home from home care” OR “Home health aides” OR “Home helps” OR “Hospices” OR “Hostel wards” OR “Informal care” OR “Integrated care pathways” OR “Intentional care” OR “Intermediate care” OR “Intermediate care centres” OR “Lack of care” OR “Learning disability nursing” OR “Length of stay” OR “Liaison nursing” OR “Long stay wards” OR “Long term care” OR “Long term home care” OR “Long term residential care” OR “Nurse led care” OR “Nursing” OR “Occupational health nursing” OR “Ontological care” OR “Out of home care” OR “Outreach nursing” OR “Palliative care” OR “Paranursing” OR “Pastoral care” OR “Patient care” OR “Primary nursing” OR “Private residential care” OR “Process centred care” OR “Quality of care” OR “Radical health visiting” OR “Residential care” OR “Residential group care” OR “Respite care” OR “Shared care” OR “Social care” “Temporary care” OR “Terminal care” OR “Wards”) OR (SU.EXACT(“Terminally ill elderly people”) OR SU.EXACT(“Terminally ill fathers”) OR SU.EXACT(“Terminally ill elderly men”) OR SU.EXACT(“Terminally ill elderly women”) OR SU.EXACT(“Terminally ill young adults”) OR SU.EXACT(“Terminally ill parents”) OR SU.EXACT(“Terminally ill women”) OR SU.EXACT(“Terminally ill widowed sisters”) OR SU.EXACT(“Terminally ill colleagues”) OR SU.EXACT(“Terminally ill young girls”) OR SU.EXACT(“Terminally ill people”) OR SU.EXACT(“Terminally ill men”)) OR SU.EXACT(“Advance directives” OR “Do not resuscitate orders” OR “Durable power of attorney for health care” OR “Living wills” OR “Treatment preferences” OR “Treatment needs”)) OR (ti,ab((advance* or patient*) N/3 (care or caring) N/3 (continu* or plan*)) or ti,ab(attitude* N/3 (death* or dying*)) or ti,ab(end N/2 life) or ti,ab(EOLC) or ti,ab((last or final) N/2 (year or month*) N/2 life) or ti,ab((dying or death) N/2 (patient* or person* or people or care or caring))))) OR SU.EXACT(“End of life decisions”)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab10"><div id="ch2.appb.tab10" class="table"><h3><span class="label">Table 13</span><span class="title">Database date parameters and filters used</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab10/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab10_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Database</th><th id="hd_h_ch2.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Dates searched</th><th id="hd_h_ch2.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Search filter used</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medline</td><td headers="hd_h_ch2.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2014 – 04 January 2019</td><td headers="hd_h_ch2.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Exclusions</p>
|
|
<p>Health economics studies</p>
|
|
<p>Health economics modelling studies</p>
|
|
<p>Quality of life studies</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase</td><td headers="hd_h_ch2.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2014 – 04 January 2019</td><td headers="hd_h_ch2.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Exclusions</p>
|
|
<p>Health economics studies</p>
|
|
<p>Health economics modelling studies</p>
|
|
<p>Quality of life studies</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appb.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Centre for Research and Dissemination (CRD)</td><td headers="hd_h_ch2.appb.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>HTA - Inception – 04 January 2019</p>
|
|
<p>NHSEED - Inception to March 2015</p>
|
|
</td><td headers="hd_h_ch2.appb.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab11"><div id="ch2.appb.tab11" class="table"><h3><span class="title">Medline (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab11/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab11_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Palliative care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Terminal care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospice care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Terminally Ill/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 (care* or caring or ill*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nursing Homes/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Respite Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hospices/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Advance Care Planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Continuity of Patient Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Physician-Patient Relations/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Long-Term Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*“Delivery of Health Care”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–29</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">news/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp historical article/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anecdotes as Topic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">comment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/31–38</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39 not 40</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animals/ not humans/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animals, Laboratory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experimentation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Models, Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodentia/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/41–47</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30 not 48</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 49 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50 not 51</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">economics/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">value of life/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp “costs and cost analysis”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Economics, Hospital/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Economics, medical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Economics, nursing/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">economics, pharmaceutical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp “Fees and Charges”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp budgets/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cost*.ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(economic* or pharmaco?economic*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(price* or pricing*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(cost* adj2 (effectiv* or utilit* or benefit* or minimi* or unit* or estimat* or variable*)).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(financ* or fee or fees).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(value adj2 (money or monetary)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/53–68</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp models, economic/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Models, Theoretical/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Models, Organizational/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">markov chains/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">monte carlo method/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Decision Theory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(markov* or monte carlo).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">econom* model*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(decision* adj2 (tree* or analy* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/70–78</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">quality-adjusted life years/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(quality adj2 (wellbeing or well being)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">disability adjusted life.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qal* or qtime* or qwb* or daly*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(euroqol* or eq5d* or eq 5*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qol* or hql* or hqol* or h qol* or hrqol* or hr qol*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health utility* or utility score* or disutilit* or utility value*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hui or hui1 or hui2 or hui3).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health* year* equivalent* or hye or hyes).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">discrete choice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">rosser.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(willingness to pay or time tradeoff or time trade off or tto or standard gamble*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf36* or sf 36* or short form 36* or shortform 36* or shortform36*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf20 or sf 20 or short form 20 or shortform 20 or shortform20).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf12* or sf 12* or short form 12* or shortform 12* or shortform12*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf8* or sf 8* or short form 8* or shortform 8* or shortform8*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf6* or sf 6* or short form 6* or shortform 6* or shortform6*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/80–98</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">100.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52 and (69 or 79 or 99)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab12"><div id="ch2.appb.tab12" class="table"><h3><span class="title">Embase (Ovid) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab12/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab12_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Palliative therapy/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Terminal care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Hospice care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">palliat*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Terminally ill patient/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((terminal* or long term or longterm) adj2 (care* or caring or ill*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or terminal) adj (phase* or stage*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">life limit*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Nursing home/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or nursing) adj2 (home or homes)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Respite Care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((respite or day) adj2 (care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Hospice/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">hospice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care planning/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(advance* adj2 (plan* or decision* or directive*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">living will*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Patient care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Attitude to Death/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(attitude* adj3 (death* or dying*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Doctor patient relation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Long term care/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*Health care delivery/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(end adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EOLC.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((last or final) adj2 (year or month*) adj2 life).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((dying or death) adj2 (patient* or person* or people or care or caring)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–28</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or letter/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">case report/ or case study/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/30–34</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomized controlled trial/ or random*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35 not 36</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal/ not human/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">nonhuman/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Animal Experiment/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Experimental Animal/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">animal model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp Rodent/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/37–44</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29 not 45</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 46 to English language</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/)</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47 not 48</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">health economics/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp economic evaluation/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp health care cost/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp fee/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">funding/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">budget*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">cost*.ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(economic* or pharmaco?economic*).ti.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(price* or pricing*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(cost* adj2 (effectiv* or utilit* or benefit* or minimi* or unit* or estimat* or variable*)).ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(financ* or fee or fees).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(value adj2 (money or monetary)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/50–62</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">statistical model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp economic aspect/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64 and 65</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*theoretical model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*nonbiological model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">stochastic model/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">decision theory/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">decision tree/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">monte carlo method/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(markov* or monte carlo).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">econom* model*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(decision* adj2 (tree* or analy* or model*)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/66–75</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">quality-adjusted life years/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">“quality of life index”/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">short form 12/ or short form 20/ or short form 36/ or short form 8/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile/</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(quality adj2 (wellbeing or well being)).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">sickness impact profile.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">83.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">disability adjusted life.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qal* or qtime* or qwb* or daly*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">85.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(euroqol* or eq5d* or eq 5*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(qol* or hql* or hqol* or h qol* or hrqol* or hr qol*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">87.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health utility* or utility score* or disutilit* or utility value*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">88.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hui or hui1 or hui2 or hui3).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">89.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(health* year* equivalent* or hye or hyes).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">discrete choice*.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">91.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">rosser.ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">92.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(willingness to pay or time tradeoff or time trade off or tto or standard gamble*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">93.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf36* or sf 36* or short form 36* or shortform 36* or shortform36*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">94.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf20 or sf 20 or short form 20 or shortform 20 or shortform20).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">95.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf12* or sf 12* or short form 12* or shortform 12* or shortform12*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">96.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf8* or sf 8* or short form 8* or shortform 8* or shortform8*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(sf6* or sf 6* or short form 6* or shortform 6* or shortform6*).ti,ab.</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">98.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/77–97</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49 and (63 or 76 or 98)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab13"><div id="ch2.appb.tab13" class="table"><h3><span class="title">NHS EED and HTA (CRD) search terms</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appb.tab13/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab13_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Palliative Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#2.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Terminal Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#3.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Hospice Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#4.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(palliat*) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#5.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Terminally Ill IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#6.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((terminal* or long term or longterm) adj2 (care* or caring or ill*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#7.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((dying or terminal) adj (phase* or stage*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#8.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(life limit*) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#9.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Nursing Homes IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#10.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((care or nursing) adj2 (home or homes))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#11.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Respite Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#12.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((respite or day) adj2 (care or caring))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#13.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Hospices IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(hospice*) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#15.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Advance Care Planning EXPLODE ALL TREES IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#16.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((advance* adj2 (plan* or decision* or directive*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#17.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(living will*) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#18.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Patient Care Planning IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#19.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Continuity of Patient Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#20.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((advance* or patient*) adj3 (care or caring) adj3 (continu* or plan*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#21.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Attitude to Death IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#22.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((attitude* adj3 (death* or dying*))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#23.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Physician-Patient Relations IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#24.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Long-Term Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#25.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH DESCRIPTOR Delivery of Health Care IN NHSEED,HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#26.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((end adj2 life)) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#27.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(EOLC) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#28.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((last or final) adj2 (year or month*) adj2 life)) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#29.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(((dying or death) adj2 (patient* or person* or people or care or caring))) IN NHSEED, HTA</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#30.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#31.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(#30) IN NHSEED</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#32.</td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(#30) IN HTA</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appcfig1"><div id="ch2.appc.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20Flow%20chart%20of%20clinical%20study%20selection%20for%20the%20review%20of%20information%20sharing.&p=BOOKS&id=558768_ch2appcf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appcf1.jpg" alt="Figure 1. Flow chart of clinical study selection for the review of information sharing." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">Flow chart of clinical study selection for the review of information sharing</span></h3></div></article><article data-type="fig" id="figobch2appcfig2"><div id="ch2.appc.fig2" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%202.%20Flow%20chart%20of%20health%20economic%20study%20selection%20for%20the%20guideline.&p=BOOKS&id=558768_ch2appcf2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appcf2.jpg" alt="Figure 2. Flow chart of health economic study selection for the guideline." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 2</span><span class="title">Flow chart of health economic study selection for the guideline</span></h3><div class="caption"><p>* Non-relevant population, intervention, comparison, design or setting; non-English language</p></div></div></article><article data-type="fig" id="figobch2appefig3"><div id="ch2.appe.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%203.%20Number%20of%20unscheduled%20admissions%20(inpatient%20hospice%20utilisation)%20up%20to%20death.&p=BOOKS&id=558768_ch2appef3.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef3.jpg" alt="Figure 3. Number of unscheduled admissions (inpatient hospice utilisation) up to death." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 3</span><span class="title">Number of unscheduled admissions (inpatient hospice utilisation) up to death</span></h3></div></article><article data-type="fig" id="figobch2appefig4"><div id="ch2.appe.fig4" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%204.%20Preferred%20and%20actual%20place%20of%20death%20(Hospital%20deaths).&p=BOOKS&id=558768_ch2appef4.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef4.jpg" alt="Figure 4. Preferred and actual place of death (Hospital deaths)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 4</span><span class="title">Preferred and actual place of death (Hospital deaths)</span></h3></div></article><article data-type="fig" id="figobch2appefig5"><div id="ch2.appe.fig5" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%205.%20Number%20of%20visits%20to%20accident%20and%20emergency%20(People%20with%20%022652%20emergency%20room%20visits)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef5.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef5.jpg" alt="Figure 5. Number of visits to accident and emergency (People with ≥2 emergency room visits) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 5</span><span class="title">Number of visits to accident and emergency (People with ≥2 emergency room visits) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig6"><div id="ch2.appe.fig6" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%206.%20Number%20of%20unscheduled%20admissions%20at%20hospital%20(People%20with%20%022652%20hospital%20admissions)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef6.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef6.jpg" alt="Figure 6. Number of unscheduled admissions at hospital (People with ≥2 hospital admissions) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 6</span><span class="title">Number of unscheduled admissions at hospital (People with ≥2 hospital admissions) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig7"><div id="ch2.appe.fig7" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%207.%20Hospitalisation%20(People%20with%20%3E14%20days%20of%20hospital%20admission)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef7.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef7.jpg" alt="Figure 7. Hospitalisation (People with >14 days of hospital admission) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 7</span><span class="title">Hospitalisation (People with >14 days of hospital admission) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig8"><div id="ch2.appe.fig8" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%208.%20Avoidable%2Finappropriate%20admissions%20to%20ICU%20(People%20with%20any%20ICU%20admissions).&p=BOOKS&id=558768_ch2appef8.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef8.jpg" alt="Figure 8. Avoidable/inappropriate admissions to ICU (People with any ICU admissions)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 8</span><span class="title">Avoidable/inappropriate admissions to ICU (People with any ICU admissions)</span></h3></div></article><article data-type="fig" id="figobch2appefig9"><div id="ch2.appe.fig9" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%209.%20Number%20of%20visits%20to%20accident%20and%20emergency%20(people%20with%20any%20number%20of%20emergency%20room%20visits)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef9.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef9.jpg" alt="Figure 9. Number of visits to accident and emergency (people with any number of emergency room visits) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 9</span><span class="title">Number of visits to accident and emergency (people with any number of emergency room visits) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig10"><div id="ch2.appe.fig10" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2010.%20Number%20of%20unscheduled%20admissions%20at%20hospital%20(People%20with%20any%20number%20of%20hospital%20admissions)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef10.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef10.jpg" alt="Figure 10. Number of unscheduled admissions at hospital (People with any number of hospital admissions) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 10</span><span class="title">Number of unscheduled admissions at hospital (People with any number of hospital admissions) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig11"><div id="ch2.appe.fig11" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2011.%20Preferred%20and%20actual%20place%20of%20death%20(ICU%20deaths).&p=BOOKS&id=558768_ch2appef11.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef11.jpg" alt="Figure 11. Preferred and actual place of death (ICU deaths)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 11</span><span class="title">Preferred and actual place of death (ICU deaths)</span></h3></div></article><article data-type="fig" id="figobch2appefig12"><div id="ch2.appe.fig12" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2012.%20Hospitalisation%20(Hospitalised%20in%20the%20last%203%20months%20of%20life).&p=BOOKS&id=558768_ch2appef12.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef12.jpg" alt="Figure 12. Hospitalisation (Hospitalised in the last 3 months of life)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 12</span><span class="title">Hospitalisation (Hospitalised in the last 3 months of life)</span></h3></div></article><article data-type="fig" id="figobch2appefig13"><div id="ch2.appe.fig13" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2013.%20Quality%20of%20life%20at%203%20months%20(FACET-Pal%2C%200%02013184).&p=BOOKS&id=558768_ch2appef13.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef13.jpg" alt="Figure 13. Quality of life at 3 months (FACET-Pal, 0–184)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 13</span><span class="title">Quality of life at 3 months (FACET-Pal, 0–184)</span></h3></div></article><article data-type="fig" id="figobch2appefig14"><div id="ch2.appe.fig14" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2014.%20Quality%20of%20life%20at%206%20months%20(FACET-Pal%2C%200%02013184).&p=BOOKS&id=558768_ch2appef14.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef14.jpg" alt="Figure 14. Quality of life at 6 months (FACET-Pal, 0–184)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 14</span><span class="title">Quality of life at 6 months (FACET-Pal, 0–184)</span></h3></div></article><article data-type="fig" id="figobch2appefig15"><div id="ch2.appe.fig15" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2015.%20Quality%20of%20life%20at%2012%20months%20(FACET-Pal%2C%200%02013184).&p=BOOKS&id=558768_ch2appef15.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef15.jpg" alt="Figure 15. Quality of life at 12 months (FACET-Pal, 0–184)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 15</span><span class="title">Quality of life at 12 months (FACET-Pal, 0–184)</span></h3></div></article><article data-type="fig" id="figobch2appefig16"><div id="ch2.appe.fig16" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2016.%20Place%20of%20death%20(participants%20who%20died%20at%20home).&p=BOOKS&id=558768_ch2appef16.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef16.jpg" alt="Figure 16. Place of death (participants who died at home)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 16</span><span class="title">Place of death (participants who died at home)</span></h3></div></article><article data-type="fig" id="figobch2appefig17"><div id="ch2.appe.fig17" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2017.%20Number%20of%20visits%20to%20accident%20and%20emergency%20(People%20with%20any%20number%20of%20emergency%20room%20visits)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef17.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef17.jpg" alt="Figure 17. Number of visits to accident and emergency (People with any number of emergency room visits) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 17</span><span class="title">Number of visits to accident and emergency (People with any number of emergency room visits) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig18"><div id="ch2.appe.fig18" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2018.%20Number%20of%20visits%20to%20accident%20and%20emergency%20(People%20with%20%022652%20emergency%20room%20visits)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef18.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef18.jpg" alt="Figure 18. Number of visits to accident and emergency (People with ≥2 emergency room visits) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 18</span><span class="title">Number of visits to accident and emergency (People with ≥2 emergency room visits) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig19"><div id="ch2.appe.fig19" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2019.%20Number%20of%20unscheduled%20admissions%20at%20hospital%20(People%20with%20any%20number%20of%20hospital%20admissions)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef19.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef19.jpg" alt="Figure 19. Number of unscheduled admissions at hospital (People with any number of hospital admissions) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 19</span><span class="title">Number of unscheduled admissions at hospital (People with any number of hospital admissions) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig20"><div id="ch2.appe.fig20" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2020.%20Number%20of%20unscheduled%20admissions%20at%20hospital%20(People%20with%20%022652%20hospital%20admissions)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef20.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef20.jpg" alt="Figure 20. Number of unscheduled admissions at hospital (People with ≥2 hospital admissions) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 20</span><span class="title">Number of unscheduled admissions at hospital (People with ≥2 hospital admissions) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig21"><div id="ch2.appe.fig21" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2021.%20Hospitalisation%20(People%20with%20%3E14%20days%20of%20hospital%20admission)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef21.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef21.jpg" alt="Figure 21. Hospitalisation (People with >14 days of hospital admission) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 21</span><span class="title">Hospitalisation (People with >14 days of hospital admission) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig22"><div id="ch2.appe.fig22" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2022.%20Preferred%20and%20actual%20place%20of%20death%20(Hospital%20deaths).&p=BOOKS&id=558768_ch2appef22.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef22.jpg" alt="Figure 22. Preferred and actual place of death (Hospital deaths)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 22</span><span class="title">Preferred and actual place of death (Hospital deaths)</span></h3></div></article><article data-type="fig" id="figobch2appefig23"><div id="ch2.appe.fig23" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2023.%20Preferred%20and%20actual%20place%20of%20death%20(ICU%20deaths).&p=BOOKS&id=558768_ch2appef23.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef23.jpg" alt="Figure 23. Preferred and actual place of death (ICU deaths)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 23</span><span class="title">Preferred and actual place of death (ICU deaths)</span></h3></div></article><article data-type="fig" id="figobch2appefig24"><div id="ch2.appe.fig24" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2024.%20Avoidable%2Finappropriate%20admissions%20to%20ICU%20(People%20with%20any%20ICU%20admissions)%20within%20last%2030%20days%20of%20life.&p=BOOKS&id=558768_ch2appef24.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef24.jpg" alt="Figure 24. Avoidable/inappropriate admissions to ICU (People with any ICU admissions) within last 30 days of life." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 24</span><span class="title">Avoidable/inappropriate admissions to ICU (People with any ICU admissions) within last 30 days of life</span></h3></div></article><article data-type="fig" id="figobch2appefig25"><div id="ch2.appe.fig25" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2025.%20Preferred%20and%20actual%20place%20of%20death%20(home%20deaths%20%02013%20male%20patients).&p=BOOKS&id=558768_ch2appef25.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef25.jpg" alt="Figure 25. Preferred and actual place of death (home deaths – male patients)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 25</span><span class="title">Preferred and actual place of death (home deaths – male patients)</span></h3></div></article><article data-type="fig" id="figobch2appefig26"><div id="ch2.appe.fig26" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2026.%20Preferred%20and%20actual%20place%20of%20death%20(home%20deaths%20%02013%20female%20patients).&p=BOOKS&id=558768_ch2appef26.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef26.jpg" alt="Figure 26. Preferred and actual place of death (home deaths – female patients)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 26</span><span class="title">Preferred and actual place of death (home deaths – female patients)</span></h3></div></article><article data-type="fig" id="figobch2appefig27"><div id="ch2.appe.fig27" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2027.%20Preferred%20and%20actual%20place%20of%20death%20(inpatient%20hospice%20deaths%20%02013%20male%20patients).&p=BOOKS&id=558768_ch2appef27.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef27.jpg" alt="Figure 27. Preferred and actual place of death (inpatient hospice deaths – male patients)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 27</span><span class="title">Preferred and actual place of death (inpatient hospice deaths – male patients)</span></h3></div></article><article data-type="fig" id="figobch2appefig28"><div id="ch2.appe.fig28" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2028.%20Preferred%20and%20actual%20place%20of%20death%20(inpatient%20hospice%20deaths%20%02013%20female%20patients).&p=BOOKS&id=558768_ch2appef28.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK558768/bin/ch2appef28.jpg" alt="Figure 28. Preferred and actual place of death (inpatient hospice deaths – female patients)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 28</span><span class="title">Preferred and actual place of death (inpatient hospice deaths – female patients)</span></h3></div></article><article data-type="table-wrap" id="figobch2appftab1"><div id="ch2.appf.tab1" class="table"><h3><span class="label">Table 14</span><span class="title">Clinical evidence profile: Early (> 3 months between first palliative care consultation and death) versus late (< 3 months between first palliative care consultation and death) referral to palliative care services</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appf.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appf.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.appf.tab1_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch2.appf.tab1_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch2.appf.tab1_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch2.appf.tab1_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch2.appf.tab1_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch2.appf.tab1_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch2.appf.tab1_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1" id="hd_h_ch2.appf.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch2.appf.tab1_1_1_1_1" id="hd_h_ch2.appf.tab1_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch2.appf.tab1_1_1_1_1" id="hd_h_ch2.appf.tab1_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch2.appf.tab1_1_1_1_1" id="hd_h_ch2.appf.tab1_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch2.appf.tab1_1_1_1_1" id="hd_h_ch2.appf.tab1_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch2.appf.tab1_1_1_1_1" id="hd_h_ch2.appf.tab1_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch2.appf.tab1_1_1_1_1" id="hd_h_ch2.appf.tab1_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch2.appf.tab1_1_1_1_2" id="hd_h_ch2.appf.tab1_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">>3 months</th><th headers="hd_h_ch2.appf.tab1_1_1_1_2" id="hd_h_ch2.appf.tab1_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"><3 months</th><th headers="hd_h_ch2.appf.tab1_1_1_1_3" id="hd_h_ch2.appf.tab1_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch2.appf.tab1_1_1_1_3" id="hd_h_ch2.appf.tab1_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of unscheduled admissions (Inpatient hospice utilisation) (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>40/54</p>
|
|
<p>(74.1%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>99/211</p>
|
|
<p>(46.9%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 1.58 (1.28 to 1.95)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">272 more per 1000 (from 131 more to 446 more)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁⨁◯◯</p>
|
|
<p>LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Preferred and actual place of death (Hospital death) (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>81/196</p>
|
|
<p>(41.3%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>325/534</p>
|
|
<p>(60.9%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.81 (0.71 to 0.93)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">116 fewer per 1000 (from 43 fewer to 176 fewer)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of visits to accident and emergency (People with ≥2 emergency room visits) (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>18/174</p>
|
|
<p>(10.3%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>67/457</p>
|
|
<p>(14.7%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.62 (0.38 to 1)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">56 fewer per 1000 (from 56 fewer to 0 more)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of unscheduled admissions (People with ≥2 hospital admissions) (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>14/174</p>
|
|
<p>(8%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>71/457</p>
|
|
<p>(15.5%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.46 (0.27 to 0.8)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">84 fewer per 1000 (from 31 fewer to 113 fewer)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Hospitalisation (People with >14 days of hospitalisation) (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>43/174</p>
|
|
<p>(24.7%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>182/457</p>
|
|
<p>(39.8%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.77 (0.60 to 0.99)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">92 fewer per 1000 (from 4 fewer to 159 fewer)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Avoidable/inappropriate admissions to ICU (People with any ICU admission) (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>10/174</p>
|
|
<p>(5.7%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>49/457</p>
|
|
<p>(10.7%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.53 (0.27 to 1.02)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">50 fewer per 1000 (from 78 fewer to 2 more)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of visits to accident and emergency (People with any number of emergency room visits)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>47/120</p>
|
|
<p>(39.2%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>168/246</p>
|
|
<p>(68.3%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.57 (0.45 to 0.73)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">294 fewer per 1000 (from 184 fewer to 376 fewer)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁⨁◯◯</p>
|
|
<p>LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of unscheduled admissions (People with any hospital admission) (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>58/120</p>
|
|
<p>(48.3%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>200/246</p>
|
|
<p>(81.3%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.59 (0.49 to 0.72)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">333 fewer per 1000 (from 228 fewer to 415 fewer)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Preferred and actual place of death (ICU death) (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>3/120</p>
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<p>(2.5%)</p>
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</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>10/246</p>
|
|
<p>(4.1%)</p>
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</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.62 (0.17 to 2.19)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15 fewer per 1000 (from 34 fewer to 48 more)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_h_ch2.appf.tab1_1_1_2_3 hd_h_ch2.appf.tab1_1_1_2_4 hd_h_ch2.appf.tab1_1_1_2_5 hd_h_ch2.appf.tab1_1_1_2_6 hd_h_ch2.appf.tab1_1_1_2_7 hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_h_ch2.appf.tab1_1_1_2_9 hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_h_ch2.appf.tab1_1_1_2_11 hd_h_ch2.appf.tab1_1_1_1_4 hd_h_ch2.appf.tab1_1_1_1_5" id="hd_b_ch2.appf.tab1_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Hospitalised in last 3 months of life (follow-up mean 1 year)</th></tr><tr><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_1 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_2 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_3 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>1</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_4 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_5 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_6 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab1_1_1_1_1 hd_h_ch2.appf.tab1_1_1_2_7 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_8 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>16/22</p>
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|
<p>(72.7%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_2 hd_h_ch2.appf.tab1_1_1_2_9 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>75/77</p>
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|
<p>(97.4%)</p>
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|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_10 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.75 (0.58 to 0.97)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_3 hd_h_ch2.appf.tab1_1_1_2_11 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">244 fewer per 1000 (from 29 fewer to 409 fewer)</td><td headers="hd_h_ch2.appf.tab1_1_1_1_4 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_ch2.appf.tab1_1_1_1_5 hd_b_ch2.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.appf.tab1_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was from studies with observational/non-randomised study design</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.appf.tab1_2"><p class="no_margin">Downgraded by 1 increment because the majority of the evidence had indirect outcomes</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.appf.tab1_3"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2appftab2"><div id="ch2.appf.tab2" class="table"><h3><span class="label">Table 15</span><span class="title">Clinical evidence profile: Early (> 30 days between diagnosis and referral) versus late (< 3 months between diagnosis and referral) referral to palliative care services</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appf.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appf.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.appf.tab2_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch2.appf.tab2_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch2.appf.tab2_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch2.appf.tab2_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch2.appf.tab2_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch2.appf.tab2_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch2.appf.tab2_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch2.appf.tab2_1_1_1_1" id="hd_h_ch2.appf.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch2.appf.tab2_1_1_1_1" id="hd_h_ch2.appf.tab2_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch2.appf.tab2_1_1_1_1" id="hd_h_ch2.appf.tab2_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch2.appf.tab2_1_1_1_1" id="hd_h_ch2.appf.tab2_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch2.appf.tab2_1_1_1_1" id="hd_h_ch2.appf.tab2_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch2.appf.tab2_1_1_1_1" id="hd_h_ch2.appf.tab2_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch2.appf.tab2_1_1_1_1" id="hd_h_ch2.appf.tab2_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch2.appf.tab2_1_1_1_2" id="hd_h_ch2.appf.tab2_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Early</th><th headers="hd_h_ch2.appf.tab2_1_1_1_2" id="hd_h_ch2.appf.tab2_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Late</th><th headers="hd_h_ch2.appf.tab2_1_1_1_3" id="hd_h_ch2.appf.tab2_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch2.appf.tab2_1_1_1_3" id="hd_h_ch2.appf.tab2_1_1_2_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_1 hd_h_ch2.appf.tab2_1_1_2_2 hd_h_ch2.appf.tab2_1_1_2_3 hd_h_ch2.appf.tab2_1_1_2_4 hd_h_ch2.appf.tab2_1_1_2_5 hd_h_ch2.appf.tab2_1_1_2_6 hd_h_ch2.appf.tab2_1_1_2_7 hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_8 hd_h_ch2.appf.tab2_1_1_2_9 hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_10 hd_h_ch2.appf.tab2_1_1_2_11 hd_h_ch2.appf.tab2_1_1_1_4 hd_h_ch2.appf.tab2_1_1_1_5" id="hd_b_ch2.appf.tab2_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life (FACIT-PAL) (follow-up mean 3 months; range of scores: 0–184; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_1 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_2 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_3 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>a</sup></td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_4 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_5 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_6 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_7 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_8 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">72</td><td headers="hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_9 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">83</td><td headers="hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_10 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_11 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.7 higher (1.76 lower to 7.16 higher)</td><td headers="hd_h_ch2.appf.tab2_1_1_1_4 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁⨁◯◯</p>
|
|
<p>LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab2_1_1_1_5 hd_b_ch2.appf.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_1 hd_h_ch2.appf.tab2_1_1_2_2 hd_h_ch2.appf.tab2_1_1_2_3 hd_h_ch2.appf.tab2_1_1_2_4 hd_h_ch2.appf.tab2_1_1_2_5 hd_h_ch2.appf.tab2_1_1_2_6 hd_h_ch2.appf.tab2_1_1_2_7 hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_8 hd_h_ch2.appf.tab2_1_1_2_9 hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_10 hd_h_ch2.appf.tab2_1_1_2_11 hd_h_ch2.appf.tab2_1_1_1_4 hd_h_ch2.appf.tab2_1_1_1_5" id="hd_b_ch2.appf.tab2_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life (FACIT-PAL) (follow-up mean 6 months; range of scores: 0–184; Better indicated by higher values)</th></tr><tr><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_1 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_2 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_3 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>a</sup></td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_4 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_5 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_6 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_7 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_8 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">72</td><td headers="hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_9 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">83</td><td headers="hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_10 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_11 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 2.7 higher (1.76 lower to 7.16 higher)</td><td headers="hd_h_ch2.appf.tab2_1_1_1_4 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁⨁◯◯</p>
|
|
<p>LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab2_1_1_1_5 hd_b_ch2.appf.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_1 hd_h_ch2.appf.tab2_1_1_2_2 hd_h_ch2.appf.tab2_1_1_2_3 hd_h_ch2.appf.tab2_1_1_2_4 hd_h_ch2.appf.tab2_1_1_2_5 hd_h_ch2.appf.tab2_1_1_2_6 hd_h_ch2.appf.tab2_1_1_2_7 hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_8 hd_h_ch2.appf.tab2_1_1_2_9 hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_10 hd_h_ch2.appf.tab2_1_1_2_11 hd_h_ch2.appf.tab2_1_1_1_4 hd_h_ch2.appf.tab2_1_1_1_5" id="hd_b_ch2.appf.tab2_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life (FACIT-PAL) (follow-up mean 12 months; range of scores: 0–184; Better indicated by lower values)</th></tr><tr><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_1 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_2 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_3 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>a</sup></td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_4 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_5 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_6 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_7 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_8 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">72</td><td headers="hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_9 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">83</td><td headers="hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_10 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_11 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">MD 0.8 higher (3.86 lower to 5.46 higher)</td><td headers="hd_h_ch2.appf.tab2_1_1_1_4 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁⨁◯◯</p>
|
|
<p>LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab2_1_1_1_5 hd_b_ch2.appf.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_1 hd_h_ch2.appf.tab2_1_1_2_2 hd_h_ch2.appf.tab2_1_1_2_3 hd_h_ch2.appf.tab2_1_1_2_4 hd_h_ch2.appf.tab2_1_1_2_5 hd_h_ch2.appf.tab2_1_1_2_6 hd_h_ch2.appf.tab2_1_1_2_7 hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_8 hd_h_ch2.appf.tab2_1_1_2_9 hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_10 hd_h_ch2.appf.tab2_1_1_2_11 hd_h_ch2.appf.tab2_1_1_1_4 hd_h_ch2.appf.tab2_1_1_1_5" id="hd_b_ch2.appf.tab2_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Preferred and actual place of death (participants who died at home) (follow-up until death)</th></tr><tr><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_1 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_2 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">randomised trials</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_3 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_4 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_5 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_6 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab2_1_1_1_1 hd_h_ch2.appf.tab2_1_1_2_7 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_8 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>27/50</p>
|
|
<p>(54%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab2_1_1_1_2 hd_h_ch2.appf.tab2_1_1_2_9 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>28/60</p>
|
|
<p>(46.7%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_10 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 1.16 (0.8 to 1.68)</td><td headers="hd_h_ch2.appf.tab2_1_1_1_3 hd_h_ch2.appf.tab2_1_1_2_11 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">75 more per 1000 (from 93 fewer to 317 more)</td><td headers="hd_h_ch2.appf.tab2_1_1_1_4 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁⨁◯◯</p>
|
|
<p>LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab2_1_1_1_5 hd_b_ch2.appf.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.appf.tab2_1"><p class="no_margin">Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.appf.tab2_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.appf.tab2_3"><p class="no_margin">Downgraded by 1 increment because the majority of the evidence had indirect outcomes</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2appftab3"><div id="ch2.appf.tab3" class="table"><h3><span class="label">Table 16</span><span class="title">Clinical evidence profile: Early (> 6 months between first palliative care consultation and death) versus late (< 6months between first palliative care consultation and death) referral to palliative care services</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appf.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appf.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.appf.tab3_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch2.appf.tab3_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch2.appf.tab3_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch2.appf.tab3_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch2.appf.tab3_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch2.appf.tab3_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch2.appf.tab3_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1" id="hd_h_ch2.appf.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch2.appf.tab3_1_1_1_1" id="hd_h_ch2.appf.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch2.appf.tab3_1_1_1_1" id="hd_h_ch2.appf.tab3_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch2.appf.tab3_1_1_1_1" id="hd_h_ch2.appf.tab3_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch2.appf.tab3_1_1_1_1" id="hd_h_ch2.appf.tab3_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch2.appf.tab3_1_1_1_1" id="hd_h_ch2.appf.tab3_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch2.appf.tab3_1_1_1_1" id="hd_h_ch2.appf.tab3_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch2.appf.tab3_1_1_1_2" id="hd_h_ch2.appf.tab3_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Early</th><th headers="hd_h_ch2.appf.tab3_1_1_1_2" id="hd_h_ch2.appf.tab3_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Late</th><th headers="hd_h_ch2.appf.tab3_1_1_1_3" id="hd_h_ch2.appf.tab3_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch2.appf.tab3_1_1_1_3" id="hd_h_ch2.appf.tab3_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_h_ch2.appf.tab3_1_1_2_3 hd_h_ch2.appf.tab3_1_1_2_4 hd_h_ch2.appf.tab3_1_1_2_5 hd_h_ch2.appf.tab3_1_1_2_6 hd_h_ch2.appf.tab3_1_1_2_7 hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_h_ch2.appf.tab3_1_1_2_9 hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_h_ch2.appf.tab3_1_1_2_11 hd_h_ch2.appf.tab3_1_1_1_4 hd_h_ch2.appf.tab3_1_1_1_5" id="hd_b_ch2.appf.tab3_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of visits to accident and emergency (People with any number of emergency room visits) (>6 months versus <6 months) (follow-up mean 1 years)</th></tr><tr><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_3 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_4 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_5 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_6 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_7 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>28/68</p>
|
|
<p>(41.2%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_9 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>187/298</p>
|
|
<p>(62.8%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.66 (0.49 to 0.88)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_11 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">213 fewer per 1000 (from 75 fewer to 320 fewer)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_4 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_5 hd_b_ch2.appf.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_h_ch2.appf.tab3_1_1_2_3 hd_h_ch2.appf.tab3_1_1_2_4 hd_h_ch2.appf.tab3_1_1_2_5 hd_h_ch2.appf.tab3_1_1_2_6 hd_h_ch2.appf.tab3_1_1_2_7 hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_h_ch2.appf.tab3_1_1_2_9 hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_h_ch2.appf.tab3_1_1_2_11 hd_h_ch2.appf.tab3_1_1_1_4 hd_h_ch2.appf.tab3_1_1_1_5" id="hd_b_ch2.appf.tab3_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of visits to accident and emergency (People with ≥2 emergency room visits) (>6 months versus <6 months) (follow-up mean 1 years)</th></tr><tr><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_3 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_4 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_5 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_6 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_7 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>6/68</p>
|
|
<p>(8.8%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_9 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>63/298</p>
|
|
<p>(21.1%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.42 (0.19 to 0.92)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_11 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">123 fewer per 1000 (from 17 fewer to 171 fewer)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_4 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_5 hd_b_ch2.appf.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_h_ch2.appf.tab3_1_1_2_3 hd_h_ch2.appf.tab3_1_1_2_4 hd_h_ch2.appf.tab3_1_1_2_5 hd_h_ch2.appf.tab3_1_1_2_6 hd_h_ch2.appf.tab3_1_1_2_7 hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_h_ch2.appf.tab3_1_1_2_9 hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_h_ch2.appf.tab3_1_1_2_11 hd_h_ch2.appf.tab3_1_1_1_4 hd_h_ch2.appf.tab3_1_1_1_5" id="hd_b_ch2.appf.tab3_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of unscheduled admissions (People with any hospital admission) (>6 months versus <6 months) (follow-up mean 1 years)</th></tr><tr><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_3 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_4 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_5 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_6 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_7 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>35/68</p>
|
|
<p>(51.5%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_9 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>223/298</p>
|
|
<p>(74.8%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.69 (0.54 to 0.87)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_11 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">232 fewer per 1000 (from 97 fewer to 344 fewer)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_4 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_5 hd_b_ch2.appf.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_h_ch2.appf.tab3_1_1_2_3 hd_h_ch2.appf.tab3_1_1_2_4 hd_h_ch2.appf.tab3_1_1_2_5 hd_h_ch2.appf.tab3_1_1_2_6 hd_h_ch2.appf.tab3_1_1_2_7 hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_h_ch2.appf.tab3_1_1_2_9 hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_h_ch2.appf.tab3_1_1_2_11 hd_h_ch2.appf.tab3_1_1_1_4 hd_h_ch2.appf.tab3_1_1_1_5" id="hd_b_ch2.appf.tab3_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of unscheduled admissions (People with ≥2 hospital admissions) (>6 months versus <6 months) (follow-up mean 1 years)</th></tr><tr><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_3 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_4 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_5 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_6 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_7 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>9/68</p>
|
|
<p>(13.2%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_9 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>55/298</p>
|
|
<p>(18.5%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.72 (0.37 to 1.38)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_11 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">52 fewer per 1000 (from 116 fewer to 70 more)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_4 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_5 hd_b_ch2.appf.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_h_ch2.appf.tab3_1_1_2_3 hd_h_ch2.appf.tab3_1_1_2_4 hd_h_ch2.appf.tab3_1_1_2_5 hd_h_ch2.appf.tab3_1_1_2_6 hd_h_ch2.appf.tab3_1_1_2_7 hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_h_ch2.appf.tab3_1_1_2_9 hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_h_ch2.appf.tab3_1_1_2_11 hd_h_ch2.appf.tab3_1_1_1_4 hd_h_ch2.appf.tab3_1_1_1_5" id="hd_b_ch2.appf.tab3_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Hospitalisation (People with >14 days of hospitalisation) (>6 months versus <6 months) (follow-up mean 1 years)</th></tr><tr><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_3 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_4 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_5 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_6 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_7 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>7/68</p>
|
|
<p>(10.3%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_9 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>47/298</p>
|
|
<p>(15.8%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.65 (0.31 to 1.38)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_11 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">55 fewer per 1000 (from 109 fewer to 60 more)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_4 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_5 hd_b_ch2.appf.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_h_ch2.appf.tab3_1_1_2_3 hd_h_ch2.appf.tab3_1_1_2_4 hd_h_ch2.appf.tab3_1_1_2_5 hd_h_ch2.appf.tab3_1_1_2_6 hd_h_ch2.appf.tab3_1_1_2_7 hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_h_ch2.appf.tab3_1_1_2_9 hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_h_ch2.appf.tab3_1_1_2_11 hd_h_ch2.appf.tab3_1_1_1_4 hd_h_ch2.appf.tab3_1_1_1_5" id="hd_b_ch2.appf.tab3_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Preferred and actual place of death (Hospital death) (>6 months versus <6 months) (follow-up mean 1 years)</th></tr><tr><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_3 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_4 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_5 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_6 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_7 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>12/68</p>
|
|
<p>(17.6%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_9 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>85/298</p>
|
|
<p>(28.5%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.62 (0.36 to 1.07)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_11 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">108 fewer per 1000 (from 183 fewer to 20 more)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_4 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_5 hd_b_ch2.appf.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_h_ch2.appf.tab3_1_1_2_3 hd_h_ch2.appf.tab3_1_1_2_4 hd_h_ch2.appf.tab3_1_1_2_5 hd_h_ch2.appf.tab3_1_1_2_6 hd_h_ch2.appf.tab3_1_1_2_7 hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_h_ch2.appf.tab3_1_1_2_9 hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_h_ch2.appf.tab3_1_1_2_11 hd_h_ch2.appf.tab3_1_1_1_4 hd_h_ch2.appf.tab3_1_1_1_5" id="hd_b_ch2.appf.tab3_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Preferred and actual place of death (ICU death) (>6 months versus <6 months) (follow-up mean 1 years)</th></tr><tr><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_3 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_4 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_5 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_6 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_7 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>2/68</p>
|
|
<p>(2.9%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_9 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>11/298</p>
|
|
<p>(3.7%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.8 (0.18 to 3.51)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_11 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">7 fewer per 1000 (from 30 fewer to 93 more)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_4 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_5 hd_b_ch2.appf.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_h_ch2.appf.tab3_1_1_2_3 hd_h_ch2.appf.tab3_1_1_2_4 hd_h_ch2.appf.tab3_1_1_2_5 hd_h_ch2.appf.tab3_1_1_2_6 hd_h_ch2.appf.tab3_1_1_2_7 hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_h_ch2.appf.tab3_1_1_2_9 hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_h_ch2.appf.tab3_1_1_2_11 hd_h_ch2.appf.tab3_1_1_1_4 hd_h_ch2.appf.tab3_1_1_1_5" id="hd_b_ch2.appf.tab3_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Avoidable/inappropriate admissions to ICU (People with any ICU admission) (>6 months versus <6 months) (follow-up mean 1 years)</th></tr><tr><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_1 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_2 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies<sup>a</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_3 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_4 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_5 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_6 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab3_1_1_1_1 hd_h_ch2.appf.tab3_1_1_2_7 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_8 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>5/68</p>
|
|
<p>(7.4%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_2 hd_h_ch2.appf.tab3_1_1_2_9 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>30/298</p>
|
|
<p>(10.1%)</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_10 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">RR 0.73 (0.29 to 1.81)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_3 hd_h_ch2.appf.tab3_1_1_2_11 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27 fewer per 1000 (from 71 fewer to 82 more)</td><td headers="hd_h_ch2.appf.tab3_1_1_1_4 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
|
|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_ch2.appf.tab3_1_1_1_5 hd_b_ch2.appf.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.appf.tab3_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was from studies with observational/non-randomised study design.</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.appf.tab3_2"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.appf.tab3_3"><p class="no_margin">Downgraded by 1 increment because the majority of the evidence had indirect outcomes</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2appftab4"><div id="ch2.appf.tab4" class="table"><h3><span class="label">Table 17</span><span class="title">Clinical evidence profile: Early (palliative care >30 days before death) versus late (palliative care <30 days before death)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appf.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appf.tab4_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.appf.tab4_1_1_1_1" colspan="7" rowspan="1" style="text-align:center;vertical-align:middle;">Quality assessment</th><th id="hd_h_ch2.appf.tab4_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">No of patients</th><th id="hd_h_ch2.appf.tab4_1_1_1_3" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Effect</th><th id="hd_h_ch2.appf.tab4_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_ch2.appf.tab4_1_1_1_4" style="text-align:center;vertical-align:middle;">Quality</th><th id="hd_h_ch2.appf.tab4_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_ch2.appf.tab4_1_1_1_5" style="text-align:center;vertical-align:middle;">Importance</th></tr><tr><th headers="hd_h_ch2.appf.tab4_1_1_1_1" id="hd_h_ch2.appf.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No of studies</th><th headers="hd_h_ch2.appf.tab4_1_1_1_1" id="hd_h_ch2.appf.tab4_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Design</th><th headers="hd_h_ch2.appf.tab4_1_1_1_1" id="hd_h_ch2.appf.tab4_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Risk of bias</th><th headers="hd_h_ch2.appf.tab4_1_1_1_1" id="hd_h_ch2.appf.tab4_1_1_2_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Inconsistency</th><th headers="hd_h_ch2.appf.tab4_1_1_1_1" id="hd_h_ch2.appf.tab4_1_1_2_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Indirectness</th><th headers="hd_h_ch2.appf.tab4_1_1_1_1" id="hd_h_ch2.appf.tab4_1_1_2_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Imprecision</th><th headers="hd_h_ch2.appf.tab4_1_1_1_1" id="hd_h_ch2.appf.tab4_1_1_2_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Other considerations</th><th headers="hd_h_ch2.appf.tab4_1_1_1_2" id="hd_h_ch2.appf.tab4_1_1_2_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Early</th><th headers="hd_h_ch2.appf.tab4_1_1_1_2" id="hd_h_ch2.appf.tab4_1_1_2_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Late</th><th headers="hd_h_ch2.appf.tab4_1_1_1_3" id="hd_h_ch2.appf.tab4_1_1_2_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relative (95% CI)</th><th headers="hd_h_ch2.appf.tab4_1_1_1_3" id="hd_h_ch2.appf.tab4_1_1_2_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_1 hd_h_ch2.appf.tab4_1_1_2_2 hd_h_ch2.appf.tab4_1_1_2_3 hd_h_ch2.appf.tab4_1_1_2_4 hd_h_ch2.appf.tab4_1_1_2_5 hd_h_ch2.appf.tab4_1_1_2_6 hd_h_ch2.appf.tab4_1_1_2_7 hd_h_ch2.appf.tab4_1_1_1_2 hd_h_ch2.appf.tab4_1_1_2_8 hd_h_ch2.appf.tab4_1_1_2_9 hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_10 hd_h_ch2.appf.tab4_1_1_2_11 hd_h_ch2.appf.tab4_1_1_1_4 hd_h_ch2.appf.tab4_1_1_1_5" id="hd_b_ch2.appf.tab4_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Place of death (males who died at home)</th></tr><tr><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_1 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_2 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_3 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias<sup>a</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_4 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_5 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_6 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_7 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab4_1_1_1_2 hd_h_ch2.appf.tab4_1_1_2_8 hd_b_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_9" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">824</td><td headers="hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_10 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">OR 2.21 (1.34 to 3.65)</td><td headers="hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_11 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appf.tab4_1_1_1_4 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch2.appf.tab4_1_1_1_5 hd_b_ch2.appf.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_1 hd_h_ch2.appf.tab4_1_1_2_2 hd_h_ch2.appf.tab4_1_1_2_3 hd_h_ch2.appf.tab4_1_1_2_4 hd_h_ch2.appf.tab4_1_1_2_5 hd_h_ch2.appf.tab4_1_1_2_6 hd_h_ch2.appf.tab4_1_1_2_7 hd_h_ch2.appf.tab4_1_1_1_2 hd_h_ch2.appf.tab4_1_1_2_8 hd_h_ch2.appf.tab4_1_1_2_9 hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_10 hd_h_ch2.appf.tab4_1_1_2_11 hd_h_ch2.appf.tab4_1_1_1_4 hd_h_ch2.appf.tab4_1_1_1_5" id="hd_b_ch2.appf.tab4_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Place of death (females who died at home)</th></tr><tr><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_1 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_2 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_3 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias<sup>a</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_4 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_5 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_6 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_7 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab4_1_1_1_2 hd_h_ch2.appf.tab4_1_1_2_8 hd_b_ch2.appf.tab4_1_1_3_1 hd_h_ch2.appf.tab4_1_1_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:top;">824</td><td headers="hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_10 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">OR 3.33 (2.07 to 5.36)</td><td headers="hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_11 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch2.appf.tab4_1_1_1_4 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch2.appf.tab4_1_1_1_5 hd_b_ch2.appf.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_1 hd_h_ch2.appf.tab4_1_1_2_2 hd_h_ch2.appf.tab4_1_1_2_3 hd_h_ch2.appf.tab4_1_1_2_4 hd_h_ch2.appf.tab4_1_1_2_5 hd_h_ch2.appf.tab4_1_1_2_6 hd_h_ch2.appf.tab4_1_1_2_7 hd_h_ch2.appf.tab4_1_1_1_2 hd_h_ch2.appf.tab4_1_1_2_8 hd_h_ch2.appf.tab4_1_1_2_9 hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_10 hd_h_ch2.appf.tab4_1_1_2_11 hd_h_ch2.appf.tab4_1_1_1_4 hd_h_ch2.appf.tab4_1_1_1_5" id="hd_b_ch2.appf.tab4_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Place of death (males who died at inpatient hospice)</th></tr><tr><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_1 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_2 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_3 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias<sup>a</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_4 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_5 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_6 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>c</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_7 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab4_1_1_1_2 hd_h_ch2.appf.tab4_1_1_2_8 hd_b_ch2.appf.tab4_1_1_5_1 hd_h_ch2.appf.tab4_1_1_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:top;">824</td><td headers="hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_10 hd_b_ch2.appf.tab4_1_1_5_1 hd_h_ch2.appf.tab4_1_1_2_11" colspan="2" rowspan="1" style="text-align:center;vertical-align:top;">OR 2.02 (1.13 to - 3.61)</td><td headers="hd_h_ch2.appf.tab4_1_1_1_4 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch2.appf.tab4_1_1_1_5 hd_b_ch2.appf.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_1 hd_h_ch2.appf.tab4_1_1_2_2 hd_h_ch2.appf.tab4_1_1_2_3 hd_h_ch2.appf.tab4_1_1_2_4 hd_h_ch2.appf.tab4_1_1_2_5 hd_h_ch2.appf.tab4_1_1_2_6 hd_h_ch2.appf.tab4_1_1_2_7 hd_h_ch2.appf.tab4_1_1_1_2 hd_h_ch2.appf.tab4_1_1_2_8 hd_h_ch2.appf.tab4_1_1_2_9 hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_10 hd_h_ch2.appf.tab4_1_1_2_11 hd_h_ch2.appf.tab4_1_1_1_4 hd_h_ch2.appf.tab4_1_1_1_5" id="hd_b_ch2.appf.tab4_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Place of death (females who died at inpatient hospice)</th></tr><tr><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_1 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_2 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_3 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious risk of bias<sup>a</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_4 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_5 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>b</sup></td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_6 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_ch2.appf.tab4_1_1_1_1 hd_h_ch2.appf.tab4_1_1_2_7 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_ch2.appf.tab4_1_1_1_2 hd_h_ch2.appf.tab4_1_1_2_8 hd_b_ch2.appf.tab4_1_1_7_1 hd_h_ch2.appf.tab4_1_1_2_9" colspan="2" rowspan="1" style="text-align:center;vertical-align:top;">824</td><td headers="hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_10 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">OR 2.69 (1.55 to 4.67)</td><td headers="hd_h_ch2.appf.tab4_1_1_1_3 hd_h_ch2.appf.tab4_1_1_2_11 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_ch2.appf.tab4_1_1_1_4 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_ch2.appf.tab4_1_1_1_5 hd_b_ch2.appf.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">CRITICAL</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.appf.tab4_1"><p class="no_margin">Downgraded by 2 increments if the majority of the evidence was from studies with observational/non-randomised study design</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.appf.tab4_2"><p class="no_margin">Downgraded by 1 increment because the majority of the evidence had indirect outcomes</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.appf.tab4_3"><p class="no_margin">Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2appgtab1"><div id="ch2.appg.tab1" class="table"><h3><span class="label">Table 18</span><span class="title">Studies excluded from the clinical review</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.appg.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Study</th><th id="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Exclusion reason</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adams 2009<a class="bibr" href="#ch2.ref1" rid="ch2.ref1"><sup>1</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Alsirafy 2010<a class="bibr" href="#ch2.ref2" rid="ch2.ref2"><sup>2</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ansell 2007<a class="bibr" href="#ch2.ref4" rid="ch2.ref4"><sup>4</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Baek 2011<a class="bibr" href="#ch2.ref5" rid="ch2.ref5"><sup>5</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bajwah 2015<a class="bibr" href="#ch2.ref6" rid="ch2.ref6"><sup>6</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention (inappropriate definition of ‘early’ and ‘late’)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bennett 2016<a class="bibr" href="#ch2.ref8" rid="ch2.ref8"><sup>8</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Blackhall 2016<a class="bibr" href="#ch2.ref9" rid="ch2.ref9"><sup>9</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Broom 2012<a class="bibr" href="#ch2.ref10" rid="ch2.ref10"><sup>10</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bruera 2012<a class="bibr" href="#ch2.ref11" rid="ch2.ref11"><sup>11</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Buchman 2016<a class="bibr" href="#ch2.ref12" rid="ch2.ref12"><sup>12</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Caissie 2014<a class="bibr" href="#ch2.ref13" rid="ch2.ref13"><sup>13</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect interventions</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Campbell 2004<a class="bibr" href="#ch2.ref14" rid="ch2.ref14"><sup>14</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect interventions</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Carpenter 2017<a class="bibr" href="#ch2.ref15" rid="ch2.ref15"><sup>15</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate outcome</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Charalambous 2014<a class="bibr" href="#ch2.ref16" rid="ch2.ref16"><sup>16</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Christakis 1994<a class="bibr" href="#ch2.ref17" rid="ch2.ref17"><sup>17</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Costantini 1999<a class="bibr" href="#ch2.ref18" rid="ch2.ref18"><sup>18</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design. No relevant outcomes</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Costantini 2018{Costantini, 2018 #3547}</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design. No comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Devi 2011<a class="bibr" href="#ch2.ref21" rid="ch2.ref21"><sup>21</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Diamond 2016<a class="bibr" href="#ch2.ref22" rid="ch2.ref22"><sup>22</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Drieskens 2008<a class="bibr" href="#ch2.ref23" rid="ch2.ref23"><sup>23</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fink 2015<a class="bibr" href="#ch2.ref24" rid="ch2.ref24"><sup>24</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fukui 2011<a class="bibr" href="#ch2.ref25" rid="ch2.ref25"><sup>25</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ghazali 2011<a class="bibr" href="#ch2.ref26" rid="ch2.ref26"><sup>26</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not review population</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Glare 2013<a class="bibr" href="#ch2.ref27" rid="ch2.ref27"><sup>27</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Greer 2012<a class="bibr" href="#ch2.ref28" rid="ch2.ref28"><sup>28</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Groenvold 2017<a class="bibr" href="#ch2.ref29" rid="ch2.ref29"><sup>29</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Groenvold 2017 {Groenvold, 2017 #3107}</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropraite comparison and population</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gu 2016<a class="bibr" href="#ch2.ref30" rid="ch2.ref30"><sup>30</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Unable to locate</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gunatilake 2014<a class="bibr" href="#ch2.ref31" rid="ch2.ref31"><sup>31</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design - study protocol</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Haun 2017<a class="bibr" href="#ch2.ref32" rid="ch2.ref32"><sup>32</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hermans 2017<a class="bibr" href="#ch2.ref33" rid="ch2.ref33"><sup>33</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate intervention</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Higginson 2008<a class="bibr" href="#ch2.ref34" rid="ch2.ref34"><sup>34</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not review population</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hui 2016<a class="bibr" href="#ch2.ref36" rid="ch2.ref36"><sup>36</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect interventions</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Humphreys 2014<a class="bibr" href="#ch2.ref37" rid="ch2.ref37"><sup>37</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Jacobsen 2011<a class="bibr" href="#ch2.ref38" rid="ch2.ref38"><sup>38</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Johnsen 2013<a class="bibr" href="#ch2.ref39" rid="ch2.ref39"><sup>39</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not review population</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Johnson 2011<a class="bibr" href="#ch2.ref40" rid="ch2.ref40"><sup>40</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">King 2016<a class="bibr" href="#ch2.ref41" rid="ch2.ref41"><sup>41</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kozlov 2015<a class="bibr" href="#ch2.ref42" rid="ch2.ref42"><sup>42</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lamba 2013<a class="bibr" href="#ch2.ref43" rid="ch2.ref43"><sup>43</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lamont 2002<a class="bibr" href="#ch2.ref44" rid="ch2.ref44"><sup>44</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Le 2010<a class="bibr" href="#ch2.ref46" rid="ch2.ref46"><sup>46</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Le 2014<a class="bibr" href="#ch2.ref45" rid="ch2.ref45"><sup>45</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">LeBlanc 2015<a class="bibr" href="#ch2.ref47" rid="ch2.ref47"><sup>47</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Unable to locate</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ledoux 2015<a class="bibr" href="#ch2.ref48" rid="ch2.ref48"><sup>48</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lee 2015<a class="bibr" href="#ch2.ref49" rid="ch2.ref49"><sup>49</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lowery 2013<a class="bibr" href="#ch2.ref50" rid="ch2.ref50"><sup>50</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No relevant outcome</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Madden 2015<a class="bibr" href="#ch2.ref51" rid="ch2.ref51"><sup>51</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not review population</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Maltoni 2017<a class="bibr" href="#ch2.ref52" rid="ch2.ref52"><sup>52</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Maltoni 2016<a class="bibr" href="#ch2.ref53" rid="ch2.ref53"><sup>53</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">May 2017<a class="bibr" href="#ch2.ref54" rid="ch2.ref54"><sup>54</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mcdonald 2016<a class="bibr" href="#ch2.ref55" rid="ch2.ref55"><sup>55</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mcdonald 2016<a class="bibr" href="#ch2.ref56" rid="ch2.ref56"><sup>56</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design (abstract)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">McNamara 2013<a class="bibr" href="#ch2.ref57" rid="ch2.ref57"><sup>57</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meffert 2015<a class="bibr" href="#ch2.ref58" rid="ch2.ref58"><sup>58</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Miller 2016<a class="bibr" href="#ch2.ref59" rid="ch2.ref59"><sup>59</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Morita 2005<a class="bibr" href="#ch2.ref60" rid="ch2.ref60"><sup>60</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Morita 2009<a class="bibr" href="#ch2.ref61" rid="ch2.ref61"><sup>61</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nakajima 2016<a class="bibr" href="#ch2.ref62" rid="ch2.ref62"><sup>62</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nipp 2016<a class="bibr" href="#ch2.ref65" rid="ch2.ref65"><sup>65</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect interventions</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Norton 2007<a class="bibr" href="#ch2.ref66" rid="ch2.ref66"><sup>66</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect interventions</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">O’Leary 2014<a class="bibr" href="#ch2.ref67" rid="ch2.ref67"><sup>67</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reyes-Ortiz 2015<a class="bibr" href="#ch2.ref69" rid="ch2.ref69"><sup>69</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not review population</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rickerson 2005<a class="bibr" href="#ch2.ref70" rid="ch2.ref70"><sup>70</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Riedel 2017<a class="bibr" href="#ch2.ref71" rid="ch2.ref71"><sup>71</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Unable to locate</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Romano 2017<a class="bibr" href="#ch2.ref72" rid="ch2.ref72"><sup>72</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Salins 2016<a class="bibr" href="#ch2.ref73" rid="ch2.ref73"><sup>73</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No usable outcomes. Cross-referenced for included studies</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Scarpi 2018{Scarpi, 2018 #3554}</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schockett 2005<a class="bibr" href="#ch2.ref74" rid="ch2.ref74"><sup>74</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No relevant outcome</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Seow 2010<a class="bibr" href="#ch2.ref75" rid="ch2.ref75"><sup>75</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect interventions</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Temel 2005<a class="bibr" href="#ch2.ref76" rid="ch2.ref76"><sup>76</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design (abstract)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Temel 2010<a class="bibr" href="#ch2.ref78" rid="ch2.ref78"><sup>78</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Temel 2017<a class="bibr" href="#ch2.ref77" rid="ch2.ref77"><sup>77</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Teno 2007<a class="bibr" href="#ch2.ref79" rid="ch2.ref79"><sup>79</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No relevant outcome</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Thoonsen 2011<a class="bibr" href="#ch2.ref80" rid="ch2.ref80"><sup>80</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design - study protocol</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Vanbutsele 2015<a class="bibr" href="#ch2.ref81" rid="ch2.ref81"><sup>81</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Vanbutsele 2018{Vanbutsele, 2018 #3543}</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Von gunten 2011<a class="bibr" href="#ch2.ref82" rid="ch2.ref82"><sup>82</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Weber 2016<a class="bibr" href="#ch2.ref83" rid="ch2.ref83"><sup>83</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate comparison</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Yamagishi 2015<a class="bibr" href="#ch2.ref84" rid="ch2.ref84"><sup>84</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect interventions. Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Zagonel 2016<a class="bibr" href="#ch2.ref85" rid="ch2.ref85"><sup>85</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not review population</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Zambrano 2016<a class="bibr" href="#ch2.ref86" rid="ch2.ref86"><sup>86</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Zimmermann 2014<a class="bibr" href="#ch2.ref87" rid="ch2.ref87"><sup>87</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect interventions</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Zimmerman 2016<a class="bibr" href="#ch2.ref88" rid="ch2.ref88"><sup>88</sup></a></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inappropriate study design</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2apphtab1"><div id="ch2.apph.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK558768/table/ch2.apph.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab1_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO question</th><td headers="hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>There is a growing body of research into the benefits of introducing specialist palliative care earlier in the care of advanced cancer patients, but the committee noted that this was not the case for patients with a progressive non-cancer diagnosis who may be entering the last year of life.</p>
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<p>Population: A defined group of people with advanced progressive organ failure, or frailty, eg people with NYHA Stage IV heart failure under the care of cardiologists and heart failure nurse specialists.</p>
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<p>Intervention(s): Holistic needs assessment and advance care planning followed by immediate specialist palliative care review, in addition to any current cardiology support and specialist heart failure nurses.</p>
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<p>Comparison: People with end stage organ failure who are receiving usual care (which may include cardiology support and specialist heart failure nurses, or future SPC review).</p>
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<p>Outcome(s): quality of life, Patient and carer satisfaction;; other end of life specific PROMs; timing and number of referrals to specialist palliative care; service utilisation; achievement of preferred place of care /death; survival.</p>
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</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Importance to patients or the population</th><td headers="hd_b_ch2.apph.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>People in the last year of life may benefit from needs-based care plans and advance care planning taking into account preferences and wishes. These are done to a large extent in cancer patients, and specialist palliative care services are also heavily involved in cancer patients in the last year of life. Studies have shown benefits to cancer patients from early review of needs, care planning and SPC involvement in terms of subjective outcomes - quality of life, symptoms, mood and reduced inappropriate resource utilisation.</p>
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<p>There may be a survival advantage for some. It would be useful to show if specific groups of people with non-cancer progressive disease could also benefit in these ways. Given that the majority of older people die from chronic non-cancer conditions, this would of great importance for health and social care planning and for resource allocation.</p>
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</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relevance to NICE guidance</th><td headers="hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relevant to future updates of NICE End of Life Care Service Delivery guideline, and NICE chronic disease guidelines, which have been hampered by lack of evidence on this question.</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relevance to the NHS</th><td headers="hd_b_ch2.apph.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Clarification of role of NHS-funded SPC services for non-cancer conditions; optimal use of current resources and allocation of future resources; identification of future role for community and hospice services.</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">National priorities</th><td headers="hd_b_ch2.apph.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Some non-cancer diseases have national service frameworks but lack of evidence on this question has prevented them from having a clear strategy on how best to plan and deliver SPC services in the last year of life.</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch2.apph.tab1_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Most of the research in this area for cancer populations has been conducted in North America where the healthcare systems are very different from UK. Compared to the cancer population, the current evidence base for non-cancer conditions is limited with respect to this research question. Some studies have evaluated specialist palliative input along with conventional services or new interventions, eg in chronic lung disease, but usually focused on short-term or symptom-related outcomes.</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Equality</th><td headers="hd_b_ch2.apph.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Yes – people with chronic progressive non-cancer conditions such as lung or heart disease, MND and stroke have severe physical disabilities and may have cognitive impairment.</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch2.apph.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This should be a prospective study design, but different methodologies may be applicable. Possible approaches include: observational cohort studies; cluster or patient-level RCTs; point of care allocation studies. Both quantitative and qualitative designs are appropriate, ideally nested in the same study. There should be a preliminary feasibility study with clear criteria for progression to a larger study.</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Feasibility</th><td headers="hd_b_ch2.apph.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The embedded feasibility study should assess issues such as: the likelihood of SPC services being able to respond to increased referrals; functioning of new referral pathways including to hospices; ability to standardise the elements of SPC that can be offered; acceptability of HNA and ACP to non-cancer patients entering the last year of life; ability to conduct long-term follow-up of patients living in the community and care settings; ethical constraints such as sharing of diagnostic and prognostic information to patients with longstanding conditions and limited cognition.</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch2.apph.tab1_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">As well as NIHR, disease-specific charities such as BHF, BLF, MNDA may be interested to fund a study in their populations.</td></tr><tr><th id="hd_b_ch2.apph.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Importance</th><td headers="hd_b_ch2.apph.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High: the research is essential to inform future updates of key recommendations in this EOLC service delivery guideline and also of disease-specific NICE guidelines and national service frameworks.</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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