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class="bkr_bib"><h1 id="_NBK557360_"><span itemprop="name">Psychological interventions for the treatment of depression</span></h1><div class="subtitle">Depression in children and young people, 2019 evidence review</div><p><b>Evidence review A</b></p><p><i>NICE Guideline, No. 134</i></p><div class="half_rhythm">London: <a href="https://www.nice.org.uk" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2019 Jun</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-3396-9</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2019.</div></div><div class="bkr_clear"></div></div><div id="ch2.s1"><h2 id="_ch2_s1_">Psychological interventions for depression</h2><div id="ch2.s1.1"><h3>Review question</h3><p>What are the most effective psychological interventions for children and young people with depression?</p><div id="ch2.s1.1.1"><h4>Introduction</h4><p>Depression in children and young people can have a devastating impact on their development, ability to function and attendance at school. The 2015 NICE guidance (<a href="https://www.nice.org.uk/Guidance/CG28" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NICE guideline CG28</a>) on depression in children and young people recommends psychological interventions for people with mild or moderate to severe depression before pharmacological interventions are considered. Psychological interventions can be delivered as group interventions (e.g. group Cognitive Behavioural Therapy, CBT), using computers or other digital devices (e.g. computer CBT), as individual sessions (e.g. CBT) or as sessions involving family in addition to the child or young person with depression, either in joint sessions (e.g. family therapy) or in parallel (interpersonal psychotherapy, IPT, which includes some parent sessions, psychodynamic psychotherapy). The choice of therapy is based on the individual needs of the child or young person with depression, taking into account their history and presentation and the context in which treatment is to be provided.</p><p>The NICE guideline on depression in children and young people (<a href="https://www.nice.org.uk/Guidance/CG28" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NICE guideline CG28</a>) was reviewed in 2017 as part of NICE’s routine surveillance programme to determine whether new evidence was available that could alter the current recommendations. The surveillance report identified new evidence relating to psychological therapies for the treatment of depression in children and young people. In particular, results from the National Institute for Health Research funded IMPACT trial (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>) suggested that a brief psychosocial intervention was as clinically effective as short-term psychoanalytical therapy and CBT, while a cost-effectiveness analysis showed no difference in cost between the interventions. As a result, the decision was made to update this part of the guideline.</p><p>The aim of this review is to compare psychological interventions to determine the most effective treatments for depression in children and young people. This review identified studies that fulfilled the conditions specified in <a class="figpopup" href="/books/NBK557360/table/ch2.tab1/?report=objectonly" target="object" rid-figpopup="figch2tab1" rid-ob="figobch2tab1">Table 1</a>. For full details of the review protocol, see <a href="#ch2.appa">appendix A</a>.</p></div><div id="ch2.s1.1.2"><h4>PICO table</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab1"><a href="/books/NBK557360/table/ch2.tab1/?report=objectonly" target="object" title="Table 1" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab1" rid-ob="figobch2tab1"><img class="small-thumb" src="/books/NBK557360/table/ch2.tab1/?report=thumb" src-large="/books/NBK557360/table/ch2.tab1/?report=previmg" alt="Table 1. PICO table for psychological interventions review." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab1"><a href="/books/NBK557360/table/ch2.tab1/?report=objectonly" target="object" rid-ob="figobch2tab1">Table 1</a></h4><p class="float-caption no_bottom_margin">PICO table for psychological interventions review. </p></div></div></div><div id="ch2.s1.1.3"><h4>Methods and process</h4><p>This evidence review was developed using the methods and process described in <a href="https://www.nice.org.uk/process/pmg20/chapter/introduction-and-overview" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>
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<u>(2014)</u>. Methods specific to this review question are described in the review protocol in <a href="#ch2.appa">appendix A</a> and the methods section in <a href="#ch2.appb">appendix B</a>.</p><p>The search strategies used in this review are detailed in <a href="#ch2.appc">appendix C</a>.</p><p>Declarations of interest were recorded according to <a href="https://www.nice.org.uk/Media/Default/Get-involved/Fellows%20and%20scholars%20unsecure/Conflicts-of-interest-policy.pdf" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NICE’s 2014 conflicts of interest policy</a>.</p><p>The following methods were specific for this review:
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<ol id="ch2.l7"><li id="ch2.lt46" class="half_rhythm"><div>References that were excluded from the 2015 update of this review question were also excluded in this review at the title and abstract stage if the reasons for exclusion remained valid based on the current review protocol in <a href="#ch2.appa">appendix A</a>. Any references that were potentially relevant based on changes in the review protocol from the 2015 update (such as the addition of art therapies to the list of interventions) were included at the titale and abstract stage and screened at full text. A modified version of the table of excluded references from the 2015 update is included in <a href="#ch2.appm">appendix M</a>.</div></li><li id="ch2.lt47" class="half_rhythm"><div>Controls were defined as follows:
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<ol id="ch2.l8" class="lower-alpha"><li id="ch2.lt48" class="half_rhythm"><div class="half_rhythm">Waiting list was merged with no treatment
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<ul id="ch2.l9"><li id="ch2.lt49" class="half_rhythm"><div>Participants were measured at post-treatment and did not receive anything additional during the treatment period of the intervention.</div></li></ul></div></li><li id="ch2.lt50" class="half_rhythm"><div class="half_rhythm">Monitoring
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<ul id="ch2.l10"><li id="ch2.lt51" class="half_rhythm"><div>Participants were monitored for their depression symptoms during the duration of the intervention.</div></li></ul></div></li><li id="ch2.lt52" class="half_rhythm"><div class="half_rhythm">Pill placebo
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<ul id="ch2.l11"><li id="ch2.lt53" class="half_rhythm"><div>Participants received a pill placebo matching the active treatment.</div></li></ul></div></li><li id="ch2.lt54" class="half_rhythm"><div class="half_rhythm">Attention control
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<ul id="ch2.l12"><li id="ch2.lt55" class="half_rhythm"><div>Participants had access to a programme (for example, a course, website, education, etc). that did not have the same elements of the intervention</div></li></ul></div></li><li id="ch2.lt56" class="half_rhythm"><div class="half_rhythm">Usual care
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<ul id="ch2.l13"><li id="ch2.lt57" class="half_rhythm"><div>Participants received any treatment as usual which could include other psychological interventions or antidepressants.</div></li></ul></div><div class="half_rhythm">Controls were reclassified, where necessary, into these groups based on the descriptions provided in the trials and committee input.</div></li></ol></div></li><li id="ch2.lt58" class="half_rhythm"><div>This review used the term digital CBT to cover CBT delivered online by computer or using other electronic interfaces, such as mobile phones or tablets, or by using a downloadable programme. Since the majority of the studies that included this intervention delivered it using a computer, the pairwise and NMA results refer to computer CBT, but the term digital CBT is used in the rationale to reflect the wider range of potential delivery methods.</div></li><li id="ch2.lt59" class="half_rhythm"><div>For continuous outcomes:
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<ol id="ch2.l14" class="lower-alpha"><li id="ch2.lt60" class="half_rhythm"><div>Some studies reported on more than one scale per outcome. A ranked list of scales was developed for each outcome to prioritise data extraction with the result that only one scale was extracted per outcome per study. The prioritisation was based on committee suggestions of the most frequently used scales in the included studies and a hierarchy of depression symptom severity measurement scales reported by a Cochrane review of newer generation antidepressants for depressive disorders in children and adolescents (<a class="bibr" href="#ch2.appo.ref269" rid="ch2.appo.ref269">Hetrick 2012</a>). See <a class="figpopup" href="/books/NBK557360/table/ch2.appq.tab1/?report=objectonly" target="object" rid-figpopup="figch2appqtab1" rid-ob="figobch2appqtab1">Table 42</a> in <a href="#ch2.appq">appendix Q</a> for the ranking of these scales.</div></li><li id="ch2.lt61" class="half_rhythm"><div>Data from individual studies were inverted to match the direction of top ranked scale in cases where the direction of improvement was opposite to the top ranked scale prior to pooling (where pooling was possible) in a meta-analysis. Scale directions were inverted even if only one study was found per comparison and outcome to ensure that all improvements were in one direction. This aimed to simplify interpretation of the pair-wise data and was required for data export from RevMan for inclusion in the network meta-analysis (NMA). The direction was changed by multiplying the mean change in effect by −1.</div></li><li id="ch2.lt62" class="half_rhythm"><div>Continuous outcomes were reported as standardised mean differences (SMDs) if multiple studies using multiple scales were pooled for analysis. If the study/studies reported effects using a single scale then mean differences were used. However, when these results were entered into the NMA relative effectiveness charts as pairwise data, the results were converted to the same scale as the NMA results if the MDs were reported on a different scale. To do this the pooled MD was converted to a SMD in RevMan and then back converted to the chosen output scale as described below.</div></li><li id="ch2.lt63" class="half_rhythm"><div>To simplify the interpretation of continuous outcomes, pooled effect sizes were back calculated from SMDs to MDs on a single scale. The choice of scale used here was made with committee input based on top ranked/most frequently used scales in the included studies. These were the HoNOSCA scale for quality of life; CDI for depressive symptoms and CGAS for functional status.</div></li><li id="ch2.lt64" class="half_rhythm"><div>For the pairwise data shown in the GRADE and NMA tables, the back calculations were carried out using a pooled standard deviation (SD) based on the SDs from all the studies included in the network meta-analysis that reported results using this scale across all depression severity groups and timepoints.</div></li></ol></div></li><li id="ch2.lt65" class="half_rhythm"><div>For dichotomous outcomes:
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<ol id="ch2.l15" class="lower-alpha"><li id="ch2.lt66" class="half_rhythm"><div>In the case of discontinuation, the number of people who started treatment or control was taken as the sample size for use in the calculation of relative risks.</div></li><li id="ch2.lt67" class="half_rhythm"><div>Discontinuation was not reported consistently by the included RCTs and covered dropouts too in some cases. The outcome was called discontinuation for any reason to try to highlight this issue. Since the definition of remission varied greatly across studies and the data was also expected to be more variable, random effect models were used when pooling studies with different definitions of remission, irrespective of the I<sup>2</sup> value for the meta-analysis.</div></li></ol></div></li><li id="ch2.lt68" class="half_rhythm"><div>Data from <a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn (1990)</a> was excluded from the pairwise and meta-analysis of depression symptoms post-treatment as the SD provided for this outcome for one of the interventions was unreasonably large compared to the depression scale used to measure it and was likely to be a typing error. Data for other time points and outcomes were still included.</div></li><li id="ch2.lt69" class="half_rhythm"><div><a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel (2016)</a> compared IPT-A (IPT for adolescents) to IPT-A plus additional parent sessions. This was not included in the NMA because the IPT-A comparator had a reduced number of parent sessions and so was not sufficiently similar to IPT-A to be grouped in the same node of the NMA.</div></li><li id="ch2.lt70" class="half_rhythm"><div>Studies were divided into mild and moderate to severe severity groups to help the committee make different recommendations for children and young people with different severities of depression. In the 2015 update of the guideline, the studies were divided into those which recruited children and young people with a diagnosis of depression, who were considered to be the more severe group (moderate to severe depression), and those which recruited participants with depressive symptoms who were considered to be the least severe group (mild depression). The committee decided to keep this division of the studies (see discussion section for details of the rationale for this decision.)</div></li><li id="ch2.lt71" class="half_rhythm"><div>Studies reporting on children and young people with comorbidities and depression were included in this review if the focus of the intervention was treatment for depression, but excluded if the treatment was for depression <b>and</b> the comorbidty (for example for anxiety and depression). However, these studies were not included in the NMA and kept as separate subgroups in the pairwise analysis in case the presence of the comorbidity altered the effect of the intervention.</div></li><li id="ch2.lt72" class="half_rhythm"><div>The proposed subgroup analysis dividing the moderate to severe population into people with no previous depression, a previous incidence of depression or refractory depression was not carried out as the included studies did not provide this information.</div></li><li id="ch2.lt73" class="half_rhythm"><div>The following subgroups were used for all pairwise and NMA analyses, where data was available, to aid with decision making by the committee:
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<ol id="ch2.l16" class="lower-alpha"><li id="ch2.lt74" class="half_rhythm"><div>5–11 years old, mild depression</div></li><li id="ch2.lt75" class="half_rhythm"><div>12–18 years old, mild depression</div></li><li id="ch2.lt76" class="half_rhythm"><div>5–11 years old, moderate to severe depression</div></li><li id="ch2.lt77" class="half_rhythm"><div>12–18 years old, moderate to severe depression</div></li></ol></div></li><li id="ch2.lt78" class="half_rhythm"><div>Two RCTs (<a class="bibr" href="#ch2.appo.ref32" rid="ch2.appo.ref32">Ip 2016</a> and <a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>) were considered to involve the use of a particularly complex attention control. <a class="bibr" href="#ch2.appo.ref32" rid="ch2.appo.ref32">Ip (2016)</a> used a control anti-smoking website to promote a smoke-free attitude among participants, whereas <a class="bibr" href="#ch2.appo.ref131" rid="ch2.appo.ref131">Stasiak (2016)</a> used a psychoeducation computer program. Since these attention controls were more intensive than the other attention controls used by other RCTs and could be judged to be active interventions in their own right, they might have unduly skewed the results of the comparison of computer CBT to attention control. To examine whether this was the case, these RCTs were excluded from the pairwise meta-analysis as an additional sensitivity analysis.</div></li><li id="ch2.lt79" class="half_rhythm"><div>The NMA models for dichotomous outcomes were based on models from the NICE Decision Support Unit (DSU) technical support document 2 (models 1c and 1d). The models for standardised mean differences were supplied by the TSU and came from <a class="bibr" href="#ch2.appo.ref268" rid="ch2.appo.ref268">Dias et al. (2016)</a>. The models are shown in <a href="#ch2.appr">appendix R</a>.</div></li><li id="ch2.lt80" class="half_rhythm"><div>Results were reported as the posterior median and 95% credible interval from the NMA model with the best fit to the data based on the NICE Guideline Updates team criteria for model choice detailed in <a href="#ch2.appb">appendix B</a>.</div></li><li id="ch2.lt81" class="half_rhythm"><div>The DSU code presents the results of dichotomous outcomes as OR. These were converted to RR by the NICE Guideline Updates Team using the event rate in the reference treatment arm (treatment coded 1 for model output) for each dichotomous outcome. The event rate was taken from the largest trial with the relevant treatment arm for that outcome and time point.</div></li><li id="ch2.lt82" class="half_rhythm"><div>Where the data for the NMA for a dichotomous outcome (for example discontinuation) included trials with 0 events in both arms, these trials were not included as part of the analysis because trials with 0 events in both arms do not contribute evidence on the relative treatment effects in pairwise or NMA.</div></li><li id="ch2.lt83" class="half_rhythm"><div>A continuity correction was used where the data contained zero events in 1 arm of a trial, but not the other, but only if there were problems running the model. Continuity correction was used to help the models converge because there were issues with data containing 0 events. The continuity correction involved adding 0.5 to the zero event arm and its matching comparator arm and 1 to the denominator for both arms. The use of a continuity correction is noted in the model fit table.</div></li><li id="ch2.lt84" class="half_rhythm"><div>NMAs were not run for networks without useful comparisons for making recommendations. For example, in a small network where individual CBT would only be compared to 2 controls the committee were not interested in the relative effects of the controls compared to each other and the NMA would not provide additional useful information to the pairwise analysis).</div></li><li id="ch2.lt85" class="half_rhythm"><div>For models looking at continuous outcomes, MD data for each trial was converted to SMD data within the models using a different SD value per scale that was reported by the included studies. The pooled SDs for each scale were calculated using the SDs of all of the trials that reported MD data for that particular scale, outcome, age and severity subgroup and time point. However, in the cases of the Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA) for quality of life, Child Depression Inventory (CDI) for depressive symptoms and the Children’s Global Assessment Scale (CGAS) for functional status, the SD used to convert MD to SMD was the pooled SD from all of the trials reporting data using that particular scale across all of the depression age and severity subgroups and timepoints. This SD was also used to back convert the NMA results onto the chosen scale for output.</div></li><li id="ch2.lt86" class="half_rhythm"><div>The published NMA was not used as a source of data for this review as new NMAs were carried out to combine all the existing evidence and look at the outcomes of interest identified by the committee. Instead, the published NMA was used to provide evidence to support or contrast with the findings of this review. In addition, the published NMA grouped the interventions by the type of psychotherapy (for example, CBT or IPT) rather than separating interventions by the type of psychotherapy and method of delivery (for example, group CBT or individual CBT). This was not considered to be an informative approach by the committee.</div></li><li id="ch2.lt87" class="half_rhythm"><div>Inconsistency checking of the NMAs was carried (see <a href="#ch2.apps">appendix S</a>) in cases where the models contained loops of evidence. These analyses relaxed the NMA assumption that the data from trials within a loop was consistent and identified several studies as being potentially inconsistent. The characteristics of these studies and others within the loop were re-examined and sensitivity analyses were carried out removing these studies from the NMA models where potential inconsistency had been detected. The results of these analyses were compared to the original results and are discussed in the sensitivity analyses section of the quality of the evidence part of the committee discussion.</div></li><li id="ch2.lt88" class="half_rhythm"><div>The pairwise meta-analysis using RevMan converted MDs to SMDs using individual trial SDs because this is the methodology built into the software package. The NMA models standardised the studies using the pooled SDs for each scale included in the analysis. In order to check that these 2 approaches gave similar results, NMA sensitivity analyses were carried out for 2 of the key outcomes identified by the committee (functional status and depression symptoms). The post treatment time point was selected as this was the time point with the most data and the 12–18 age group was chosen for the same reason. The results of these analyses were compared to the original results and are discussed in the sensitivity analyses section of the quality of the evidence part of the committee discussion.</div></li><li id="ch2.lt89" class="half_rhythm"><div>Although there were studies at high risk of bias included in the NMA, sensitivity analyses excluding these studies were not carried out because sensitivity analyses for the pair wise data did not alter the interpretation of the effects of the treatments with 2 exceptions. These were not considered sufficient to warrant running NMA sensitivity analyses for the depression symptoms post treatment outcome for mild depression in 12–18 year olds because the excluded studies were not expected to contribute greatly to the analysis due to their small size and the number of other studies in the network that also involved individual CBT.</div></li></ol></p><p>We would like to acknowledge the Technical Support Unit, at University of Bristol, particularly Nicky Welton, Sofia Dias, Caitlin Daly and Deborah Caldwell, for providing advice, models, inconsistency checking and quality assurance for the network meta-analyses included in this review.</p><div id="ch2.s1.1.3.1"><h5>Protocol deviation</h5><p>The planned subgroup analysis looking at the effect of treatment duration on effectiveness of the therapies was not carried out because it was decided that there were too few trials for individual pairwise comparisons for this to be informative.</p><p>This review had a number of prespecified subgroups based on age and depression severity and it was planned that pooled results from the pairwise comparisons would be reported in GRADE tables unless there was evidence suggesting between subgroup heterogeneity (defined as a statistically significant test for subgroup interactions at the 95% confidence level). However, the committee decided that it was easier to use the results of the NMAs to make recommendations when they were divided up by age and severity into 4 groups (mild depression for 5–11 year olds or 12–18 year olds; moderate to severe depression for 5–11 year olds or 12–18 year olds). The pairwise analyses were reordered to match the NMAs to facilitate comparison of the pairwise and NMA results.</p><p>The protocol did not include pill placebo as a comparator as the committee did not expect that trials comparing a pharmaceutical intervention with a pill placebo would also include a psychotherapy. However, 2 trials were identified that fell into this category and otherwise fulfilled the inclusion criteria for this review. In these cases, data was extracted for the pill placebo and psychological therapy arms only.</p></div></div><div id="ch2.s1.1.4"><h4>Clinical evidence</h4><div id="ch2.s1.1.4.1"><h5>Included studies</h5><p>A systematic search was carried out to identify randomised controlled trials (RCTs) and systematic reviews of RCTs, which found 10,246 references (see <a href="#ch2.appc">appendix C</a> for the literature search strategy). Evidence identified in the 2015 update (53 references), surveillance review (32 references), from systematic reviews (see below) and post-consultation (3 references) was also reviewed. In total, 10,334 references were identified for screening at title and abstract level. 10,078 were excluded based on their titles and abstracts and 256 references (58 systematic reviews and 198 RCTs) were ordered for screening based on their full texts.</p><p>Fifty eight systematic reviews were identified in the full text screen and the most recent were used as additional sources of references (5 RCTs). In total 70 RCTs published in 85 references were included based on their relevance to the review protocol (<a href="#ch2.appa">appendix A</a>). In addition, one published NMA was identified that was relevant to this topic. The clinical evidence study selection is presented as a PRISMA diagram in <a href="#ch2.appd">appendix D</a>.</p><p>See <a href="#ch2.appo">appendix O</a> for a list of references for included studies.</p></div><div id="ch2.s1.1.4.2"><h5>Excluded studies</h5><p>See <a href="#ch2.appm">appendix M</a> for a list of excluded studies with reasons for exclusion and <a href="#ch2.appo">appendix O</a> for the bibliographic reference.</p></div></div><div id="ch2.s1.1.5"><h4>Summary of clinical studies included in the evidence review</h4><p>The included RCTs are summarised in <a class="figpopup" href="/books/NBK557360/table/ch2.tab2/?report=objectonly" target="object" rid-figpopup="figch2tab2" rid-ob="figobch2tab2">Table 2</a> (RCTs for all age and depression severity groups), (5–11 year olds with mild depression), <a class="figpopup" href="/books/NBK557360/table/ch2.tab4/?report=objectonly" target="object" rid-figpopup="figch2tab4" rid-ob="figobch2tab4">Table 4</a> (12–18 year olds with mild depression), <a class="figpopup" href="/books/NBK557360/table/ch2.tab5/?report=objectonly" target="object" rid-figpopup="figch2tab5" rid-ob="figobch2tab5">Table 5</a> (5–11 year olds with moderate to severe depression), <a class="figpopup" href="/books/NBK557360/table/ch2.tab6/?report=objectonly" target="object" rid-figpopup="figch2tab6" rid-ob="figobch2tab6">Table 6</a> (12–18 year olds with moderate to severe depression) and <a class="figpopup" href="/books/NBK557360/table/ch2.tab7/?report=objectonly" target="object" rid-figpopup="figch2tab7" rid-ob="figobch2tab7">Table 7</a> (summary of the characteristics of the RCTs).</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab2"><a href="/books/NBK557360/table/ch2.tab2/?report=objectonly" target="object" title="Table 2" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab2" rid-ob="figobch2tab2"><img class="small-thumb" src="/books/NBK557360/table/ch2.tab2/?report=thumb" src-large="/books/NBK557360/table/ch2.tab2/?report=previmg" alt="Table 2. Number of included studies for each comparison for all age and depression severity groups. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab2"><a href="/books/NBK557360/table/ch2.tab2/?report=objectonly" target="object" rid-ob="figobch2tab2">Table 2</a></h4><p class="float-caption no_bottom_margin">Number of included studies for each comparison for all age and depression severity groups. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons. <a href="/books/NBK557360/table/ch2.tab2/?report=objectonly" target="object" rid-ob="figobch2tab2">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab3"><a href="/books/NBK557360/table/ch2.tab3/?report=objectonly" target="object" title="Table 3" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab3" rid-ob="figobch2tab3"><img class="small-thumb" src="/books/NBK557360/table/ch2.tab3/?report=thumb" src-large="/books/NBK557360/table/ch2.tab3/?report=previmg" alt="Table 3. Number of included studies for each comparison for mild depression, age 5–11 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab3"><a href="/books/NBK557360/table/ch2.tab3/?report=objectonly" target="object" rid-ob="figobch2tab3">Table 3</a></h4><p class="float-caption no_bottom_margin">Number of included studies for each comparison for mild depression, age 5–11 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons. <a href="/books/NBK557360/table/ch2.tab3/?report=objectonly" target="object" rid-ob="figobch2tab3">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab4"><a href="/books/NBK557360/table/ch2.tab4/?report=objectonly" target="object" title="Table 4" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab4" rid-ob="figobch2tab4"><img class="small-thumb" src="/books/NBK557360/table/ch2.tab4/?report=thumb" src-large="/books/NBK557360/table/ch2.tab4/?report=previmg" alt="Table 4. Number of included studies for each comparison for mild depression, age 12–18 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab4"><a href="/books/NBK557360/table/ch2.tab4/?report=objectonly" target="object" rid-ob="figobch2tab4">Table 4</a></h4><p class="float-caption no_bottom_margin">Number of included studies for each comparison for mild depression, age 12–18 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all <a href="/books/NBK557360/table/ch2.tab4/?report=objectonly" target="object" rid-ob="figobch2tab4">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab5"><a href="/books/NBK557360/table/ch2.tab5/?report=objectonly" target="object" title="Table 5" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab5" rid-ob="figobch2tab5"><img class="small-thumb" src="/books/NBK557360/table/ch2.tab5/?report=thumb" src-large="/books/NBK557360/table/ch2.tab5/?report=previmg" alt="Table 5. Number of included studies for each comparison for moderate to severe depression, age 5–11 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab5"><a href="/books/NBK557360/table/ch2.tab5/?report=objectonly" target="object" rid-ob="figobch2tab5">Table 5</a></h4><p class="float-caption no_bottom_margin">Number of included studies for each comparison for moderate to severe depression, age 5–11 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting <a href="/books/NBK557360/table/ch2.tab5/?report=objectonly" target="object" rid-ob="figobch2tab5">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab6"><a href="/books/NBK557360/table/ch2.tab6/?report=objectonly" target="object" title="Table 6" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab6" rid-ob="figobch2tab6"><img class="small-thumb" src="/books/NBK557360/table/ch2.tab6/?report=thumb" src-large="/books/NBK557360/table/ch2.tab6/?report=previmg" alt="Table 6. Number of included studies for each comparison for moderate to severe depression, age 12–18 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab6"><a href="/books/NBK557360/table/ch2.tab6/?report=objectonly" target="object" rid-ob="figobch2tab6">Table 6</a></h4><p class="float-caption no_bottom_margin">Number of included studies for each comparison for moderate to severe depression, age 12–18 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting <a href="/books/NBK557360/table/ch2.tab6/?report=objectonly" target="object" rid-ob="figobch2tab6">(more...)</a></p></div></div><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab7"><a href="/books/NBK557360/table/ch2.tab7/?report=objectonly" target="object" title="Table 7" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab7" rid-ob="figobch2tab7"><img class="small-thumb" src="/books/NBK557360/table/ch2.tab7/?report=thumb" src-large="/books/NBK557360/table/ch2.tab7/?report=previmg" alt="Table 7. Summary of the characteristics of the included studies." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab7"><a href="/books/NBK557360/table/ch2.tab7/?report=objectonly" target="object" rid-ob="figobch2tab7">Table 7</a></h4><p class="float-caption no_bottom_margin">Summary of the characteristics of the included studies. Studies were classified into 2 age groups: 5 to 11 years and 12 to 18 years. This classification was based on age range or mean age reported by the studies. Classifications used in the 2015 update <a href="/books/NBK557360/table/ch2.tab7/?report=objectonly" target="object" rid-ob="figobch2tab7">(more...)</a></p></div></div><p>See <a href="#ch2.appe">appendix E</a> for full evidence tables.</p></div><div id="ch2.s1.1.6"><h4>Quality assessment of clinical studies included in the evidence review</h4><p>See evidence tables in <a href="#ch2.appe">appendix E</a> for quality assessment of individual studies, <a href="#ch2.appf">appendix F</a> for forest plots and <a href="#ch2.apph">appendix H</a> for GRADE tables.</p></div><div id="ch2.s1.1.7"><h4>Economic evidence</h4><div id="ch2.s1.1.7.1"><h5>Included studies</h5><p>A search was conducted to identify economic evaluations relevant to the review question with a date limit of the previous 2014 guideline (<a href="#ch2.appc">Appendix C</a>). The search returned a total of 4,031 records, 4,015 of which were exclude on the basis of title and abstract. The remaining 16 studies were fully inspected and 3 were included in the synthesis. During inspection of the full publications and reference lists, an additional economic evaluation by <a class="bibr" href="#ch2.appo.ref253" rid="ch2.appo.ref253">Domino 2009</a> was identified and included in the review.</p></div><div id="ch2.s1.1.7.2"><h5>Excluded studies</h5><p>Details of excluded studies are provided in <a href="#ch2.appm">appendix M</a>.</p></div></div><div id="ch2.s1.1.8"><h4>Summary of studies included in the economic evidence review</h4><p>The 4 published economic evaluations included in the review compared cognitive behavioural (CBT) therapy with or without selective serotonin reuptake inhibitors (SSRIs) to usual care, brief psychological intervention (BPI) or short-term psychoanalytic psychotherapy (STPP). These are summarised in <a class="figpopup" href="/books/NBK557360/table/ch2.tab8/?report=objectonly" target="object" rid-figpopup="figch2tab8" rid-ob="figobch2tab8">Table 8</a> with further details in <a href="#ch2.appj">appendix J</a>.</p><div id="ch2.s1.1.8.1"><h5><a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a> (IMPACT HTA)</h5><p>Goodyer et al was a cost-effectiveness analysis conducted alongside a clinical trial comparing cognitive behavioural therapy (CBT), brief psychological intervention (BPI) and short-term psychoanalytic psychotherapy (STPP) in a population of 465 English adolescents with depression. The time horizon of the analysis comprised the 86-week duration of the trial’s follow-up and took a UK societal perspective, with education and voluntary services costs being considered. The outcomes of the interventions were assessed using the EQ-5D instrument applied at baseline and then at 6, 12, 36, 52 and 86-week follow-up sessions. System resource usage was elicited from the participants and parents/carers at the same time points. The analysis included costs of delivering BPI, CBT and STPP, NHS primary and secondary services, social care, education, voluntary sector services, and medication costs. Prices were based on usual UK sources.</p><p>In the deterministic results BPI was the most cost-effective intervention with an incremental cost-effectiveness ratio (ICER) of £23,000/QALY, although the trial did not detect any statistically significant differences in costs or outcomes and absolute differences between interventions were small. CBT was cheaper and less effective than BPI and STPP was equally effective and more expensive than BPI. The probabilistic results suggest that CBT had a greater than 50% probability of being the most cost-effective treatment regardless of the willingness to pay for one additional QALY. The base case considered that sessions that were offered but not attended had a cost of £0, under the assumption that professionals could still make use of their time. In sensitivity analysis the cost of 50% of the offered but not attended sessions was included in the calculations raising the cost of CBT, previously the cheapest alternative. BPI became dominant with a probability greater than 50% of being the most cost-effective strategy for any willingness to pay value. Overall, the relative cost-effectiveness of the interventions assessed is very unclear.</p><p>Important limitations affecting the generalisability of the cost-effectiveness estimates in this study are the uncertainty about how levels of attendance at planned sessions reflect current clinical practice and the volume of missing data related to resource consumption. This is particularly relevant given the analysis’ sensitivity to the cost of interventions and the marginal difference in QALYs gained between comparators. The analysis took a societal perspective which deviates from NICE’s reference case. It is also unclear whether the adult version of the EQ-5D questionnaire and value set are appropriate for measuring health related quality of life in adolescents. It is also unclear whether, given the seniority of the therapists delivering BPI (>80% consultant psychiatrists), the efficacy estimates for this intervention are generalisable to current practice in the NHS.</p></div><div id="ch2.s1.1.8.2"><h5>
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<a class="bibr" href="#ch2.appo.ref251" rid="ch2.appo.ref251">Byford 2007</a>
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</h5><p><a class="bibr" href="#ch2.appo.ref251" rid="ch2.appo.ref251">Byford 2007</a> conducted a trial based economic evaluation comparing the cost effectiveness of CBT combined with SSRIs and standard clinical care with SSRIs and standard clinical care alone, in a population of 208 English adolescents with probable or diagnosed major depression. The analysis had a 28-week time horizon and was conducted from a societal perspective, including the costs of delivering the interventions, costs of health, social, education, voluntary and private service use as well as costs of travel and productivity loss from parents/guardians. The units of resource used were collected from the adolescents using the Child and Adolescent Service use Schedule (CA-SUS). Unit costs used standard UK sources as well as published literature. The outcomes of the interventions were assessed using the Health and Nation Outcome Scale for Children and Adolescents (HoNOSCA) and Euro-QOL 5 dimension (EQ-5D) instrument applied at baseline, 12 and 28 weeks.</p><p>The incremental analysis using the HoNOSCA score as the outcome measure showed that CBT in combination with SSRIs was dominated by of SSRIs with standard care. This means that CBT was more expensive and less effective than the SSRIs with standard clinical care comparator. The probabilistic results showed that the probability of CBT+SSRIs being cost effective was 25% at a willingness to pay of £50,000. Results were similar when quality of life was used as an outcome, with the CBT+SSRIs interventions having a probability of being cost-effective lower than 4% at any willingness to pay threshold. Several sensitivity analysis scenarios were explored, none of which changed the direction of the results.</p><p>The main limitation of this analysis for decision making is that it considers a population of adolescents who are all receiving anti-depressants and could therefore be considered further along the care pathway than the population in this review question. It is unclear if the relative effectiveness of CBT observed in this trial is relevant. The mean attendance to CBT sessions was only 58% of planned sessions (11/19), which may have impacted the effectiveness of the intervention. Also, the duration of follow-up (28 weeks) may not suffice to capture the medium to long term effects of CBT. The analysis took a societal perspective considering the costs of education, voluntary and private sectors, such as travel costs and productivity losses, which deviates from NICE’s reference case. QALYs were valued using the adult version of EQ-5D.</p></div><div id="ch2.s1.1.8.3"><h5>
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<a class="bibr" href="#ch2.appo.ref173" rid="ch2.appo.ref173">Dickerson et al 2018</a>
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</h5><p>Dickerson et al was an economic evaluation alongside a clinical trial comparing brief CBT (median 7 acute and 3 follow-up sessions) plus treatment as usual (TAU) with TAU alone in a total of 212 adolescents declining antidepressant medication. Patients in either arm were allowed to access any TAU over the follow-up period. The time horizon of the economic evaluation was two years and it was conducted from a US societal perspective.</p><p>The study recorded and assigned costs to all service use in both arms at one and two year follow up. Depressive symptoms were assessed at baseline and at 6, 12, 25, 52, 78 and 104 weeks. This assessment also recorded Depression Free Days (DFDs), which enabled the calculation of QALYs accrued across the follow-up period assuming that DFDs had QoL = 1 and depressed days had HRQoL = 0.4.</p><p>The study found that CBT was associated with a per patient increase in QALYs of 0.109 (se 0.062) driven by an increase of 43.3 (se 24.6) DFDs over the two year follow up period. It also found a per patient decrease in costs of −$4,976 (se $2,225), making it a dominant intervention. In a sensitivity analysis excluding inpatient days (an important and influential driver of costs), the authors calculated that CBT had an ICER of $5,588 per QALY gained over TAU. The authors conducted probabilistic sensitivity analysis suggesting a 97% probability that CBT dominates TAU.</p><p>Important limitations of this study as it relates to this review question include the pragmatic nature of the trial design, the societal and US perspective, the influence that small units of differential resource use have over the incremental costs and a method for calculating QALYs that was not directly collected from trial participants and is outside NICE’s reference case. It is also not clear that the population is directly relevant as they have been offered antidepressants rather than psychological therapies.</p></div><div id="ch2.s1.1.8.4"><h5>
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<a class="bibr" href="#ch2.appo.ref253" rid="ch2.appo.ref253">Domino 2009</a>
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</h5><p>The publication by <a class="bibr" href="#ch2.appo.ref253" rid="ch2.appo.ref253">Domino 2009</a> is a trial-based economic evaluation comparing fluoxetine versus cognitive behavioural therapy (CBT) plus fluoxetine versus CBT alone. The study assessed a population of 327 adolescents aged 12 to 18 years with a primary diagnosis of major depression, and was conducted in the US using a societal perspective. The original trial incorporated clinical management with placebo to allow for a double-blind comparison with fluoxetine. The economic analysis considered the 36-week costs and outcome for the trial participants assigned to one of the active treatment arms.</p><p>The outcomes of the interventions were measured in depression free days and quality of life. Depression free days were assessed using the Children depression rating Scale Revised (CDRS-R) which was applied every 6 weeks. Scores less than 29 were considered as depression-free, scores equal or greater than 45 as not free of depression and intermediate scores were included linearly in the calculations of daily utility weights. To calculate quality-adjusted life-years (QALYs) depression-free days were assigned a utility value of 1.0, depression days to a utility weight of 0.6 and days with intermediate values were linearly interpolated (e.g. if depression-free for half a day, the total day’s utility would be 0.8). The authors recognised the limitations of calculating QALYs based on depression-free days measurement and have also calculated exploratory QALY weights from the Quality of Life Enjoyment and Satisfaction Questionnaire (PQ-LES-Q), assuming that the lowest score across time points (15) had a QALY weight of 0.6 and that the highest score (75) was associated with an utility of 1.0, intermediate values were linearly interpolated.</p><p>In addition to the costs of delivering the interventions and medication, the authors also included caregiver-reported costs incurred outside the study such as primary care, medical visits, criminal justice, school based services, emergency department visits and hospital admissions.</p><p>The study found that CBT in combination with fluoxetine was associated with an ICER of $23,067 (£20,444), dominating the alternative strategies. Parameter uncertainty was explored using bias-corrected 95% confidence intervals and 1,000 iteration bootstrapping. When the summary measure of QALY was used fluoxetine + CBT had a greater than 90% probability of being cost-effective compared to fluoxetine alone, for a willingness to pay of $100,000 (£88,632). Similar results were obtained when using QALYs generated using different instruments. When the utility weights were varied in sensitivity analysis. If QALY loss from depression was as low as 0.2, fluoxetine + CBT had an 89% probability of being more cost-effective than fluoxetine alone, at a willingness to pay of $200,000 (£177,264). If QALY loss was higher (0.6) then the combined strategy had a 94% probability of being cost-effective, compared to fluoxetine.</p><p>The study had important limitations including the societal perspective and the fact it was conducted in the US. QALY calculations used depression-free days obtained from the CDRS-R scale, this being adapted from the adult depression literature. This may be of limited validity in a population of adolescents with major depression. The authors used different strategies to explore the uncertainty around the quality of life outcome. Missing cost and efficacy data was replaced using regression estimates imputed from the patients with complete records, which may have increased the uncertainty in the estimates of the analysis.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2tab8"><a href="/books/NBK557360/table/ch2.tab8/?report=objectonly" target="object" title="Table 8" class="img_link icnblk_img figpopup" rid-figpopup="figch2tab8" rid-ob="figobch2tab8"><img class="small-thumb" src="/books/NBK557360/table/ch2.tab8/?report=thumb" src-large="/books/NBK557360/table/ch2.tab8/?report=previmg" alt="Table 8. Summary of economic evaluations included in the review." /></a><div class="icnblk_cntnt"><h4 id="ch2.tab8"><a href="/books/NBK557360/table/ch2.tab8/?report=objectonly" target="object" rid-ob="figobch2tab8">Table 8</a></h4><p class="float-caption no_bottom_margin">Summary of economic evaluations included in the review. </p></div></div></div></div><div id="ch2.s1.1.9"><h4>Economic model</h4><p>The committee has considered the published economic evidence and has decided not to prioritise original economic modelling to answer the research question. The reasons for this relate to several aspects:
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<ul id="ch2.l87"><li id="ch2.lt220" class="half_rhythm"><div>The network meta-analysis for this guideline mostly reported short term clinical outcomes that would have been difficult to tie to definitive differences in health related quality of life between the treatments.</div></li><li id="ch2.lt221" class="half_rhythm"><div>Outcomes were heterogeneously reported between trials and significant uncertainty existed in the differential effectiveness between active interventions.</div></li><li id="ch2.lt222" class="half_rhythm"><div>The number and duration of the therapies and the level of attendance is heterogeneously reported in the literature, which made the costing exercise imprecise and not necessarily representative of clinical practice.</div></li></ul></p><p>The committee considered the potential resource use associated with the interventions (see <a href="#ch2.appl">appendix L</a>) alongside the clinical evidence and found that there was sufficient evidence to inform the recommendations. The costing estimates were imprecise but provided some evidence that group and computer interventions were likely to be cheaper than individual therapies and that some individual therapies were likely to be cheaper than others.</p></div><div id="ch2.s1.1.10"><h4>Evidence statements</h4><div id="ch2.s1.1.10.1"><h5>Pairwise analysis</h5><p>The format for the evidence statements is described in <a href="#ch2.appb">appendix B</a>.</p><div id="ch2.s1.1.10.1.1"><h5>Mild depression in 5–11 year olds</h5><div id="ch2.s1.1.10.1.1.1"><h5>Depression symptoms at post-treatment</h5><p>The following psychological interventions were effective at reducing depression symptoms compared to a control:
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<ul id="ch2.l88"><li id="ch2.lt223" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 47 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.1.2"><h5>Depression symptoms at >6 to ≤18 months</h5><p>The following psychological interventions could not differentiate depression symptoms between children with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l89"><li id="ch2.lt224" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 29 participants)</div></li></ul></p></div></div><div id="ch2.s1.1.10.1.2"><h5>Mild depression in 12–18 year olds</h5><div id="ch2.s1.1.10.1.2.1"><h5>Depression symptoms at post-treatment</h5><p>The following psychological interventions were effective at reducing depression symptoms compared to a control:
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<ul id="ch2.l90"><li id="ch2.lt225" class="half_rhythm"><div>Computer CBT compared to waiting list/no treatment (low quality evidence from 2 RCTs with 142 participants)</div></li><li id="ch2.lt226" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 5 RCTs with 395 participants)</div></li><li id="ch2.lt227" class="half_rhythm"><div>Relaxation compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 18 participants)</div></li><li id="ch2.lt228" class="half_rhythm"><div>Dance therapy compared to waiting list/no treatment (low quality evidence from 1 RCT with 40 participants)</div></li><li id="ch2.lt229" class="half_rhythm"><div>Individual CBT compared to usual care (very low quality evidence from 3 RCTs with 86 participants)</div></li><li id="ch2.lt230" class="half_rhythm"><div>Guided self-help compared to attention control (low quality evidence from 1 RCT with 14 participants)</div></li></ul></p><p>The following interventions were effective at reducing depression symptoms compared to another intervention:
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<ul id="ch2.l91"><li id="ch2.lt231" class="half_rhythm"><div>Group CBT compared to guided self-help (moderate quality evidence from 1 RCT with 169 participants)</div></li><li id="ch2.lt232" class="half_rhythm"><div>Group CBT compared to group non-directive supportive therapy (moderate quality evidence from 1 RCT with 177 participants)</div></li><li id="ch2.lt233" class="half_rhythm"><div>Group mindfulness compared to group CBT (very low quality evidence from 1 RCT with 33 participants)</div></li><li id="ch2.lt234" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 110 participants)</div></li><li id="ch2.lt235" class="half_rhythm"><div>Group IPT compared to non-directive supportive therapy (low quality evidence from 3 RCTs with 280 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate depression symptoms between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l92"><li id="ch2.lt236" class="half_rhythm"><div>Individual CBT compared to waiting list/no treatment (very low quality evidence from 2 RCTs with 60 participants)</div></li><li id="ch2.lt237" class="half_rhythm"><div>Individual CBT and family education compared to waiting list (moderate quality evidence from 1 RCT with 23 participants)</div></li><li id="ch2.lt238" class="half_rhythm"><div>Computer CBT compared to attention control (low quality evidence from 3 RCTs with 386 participants)</div></li><li id="ch2.lt239" class="half_rhythm"><div>Computer CBT compared to usual care (high quality evidence from 1 RCT with 187 participants)</div></li><li id="ch2.lt240" class="half_rhythm"><div>Computer CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 107 participants)</div></li><li id="ch2.lt241" class="half_rhythm"><div>Group CBT compared to attention control (moderate quality evidence from 3 RCTs with 818 participants)</div></li><li id="ch2.lt242" class="half_rhythm"><div>Group CBT compared to usual care (low quality evidence from 3 RCTs with 798 participants)</div></li><li id="ch2.lt243" class="half_rhythm"><div>Group CBT compared to relaxation (moderate quality evidence from 2 RCTs with 47 participants)</div></li><li id="ch2.lt244" class="half_rhythm"><div>Group CBT compared to self-modelling (moderate quality evidence from 1 RCT with 34 participants)</div></li><li id="ch2.lt245" class="half_rhythm"><div>Group CBT compared to computer CBT (high quality evidence from 1 RCT with 101 participants)</div></li><li id="ch2.lt246" class="half_rhythm"><div>Group CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 106 participants)</div></li><li id="ch2.lt247" class="half_rhythm"><div>Group CBT and computer CBT compared to attention control (high quality evidence from 1 RCT with 107 participants)</div></li><li id="ch2.lt248" class="half_rhythm"><div>Family therapy compared to usual care (moderate quality evidence from 1 RCT with 66 participants)</div></li><li id="ch2.lt249" class="half_rhythm"><div>Guided self-help compared to waiting list/no treatment (very low evidence from 2 RCTs with 194 participants)</div></li><li id="ch2.lt250" class="half_rhythm"><div>Group non-directive supportive therapy compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 172 participants)</div></li><li id="ch2.lt251" class="half_rhythm"><div>Group non-directive supportive therapy compared to guided self-help (moderate quality evidence from 1 RCT with 168 participants)</div></li><li id="ch2.lt252" class="half_rhythm"><div>Relaxation compared to self-modelling (moderate quality evidence from 1 RCT with 34 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.2.1.1"><h5>Subgroup analysis with comorbidities</h5><p>The following interventions were effective at reducing depression symptoms compared to another intervention in young people with mild depression and irritable bowel syndrome:
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<ul id="ch2.l93"><li id="ch2.lt253" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 86 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.1.2"><h5>Sensitivity analysis removing studies at high risk of bias</h5><p>This sensitivity analysis showed that individual CBT became effective at reducing depression symptoms at post-treatment compared to waiting list/no treatment when studies at high risk of bias were removed.</p><p>This sensitivity analysis showed that individual CBT compared to usual care could not differentiate depression symptoms at post-treatment anymore when studies at high risk of bias were removed.</p></div><div id="ch2.s1.1.10.1.2.1.3"><h5>Sensitivity analysis removing studies with a complex attention control</h5><p>This sensitivity analysis showed similar results for depression symptoms at post-treatment with or without RCTs with a complex attention control (computer CBT compared to attention control).</p></div></div><div id="ch2.s1.1.10.1.2.2"><h5>Depression symptoms at ≤6 months</h5><p>The following psychological interventions were effective at reducing depression symptoms compared to a control:
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<ul id="ch2.l94"><li id="ch2.lt254" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 5 RCTs with 394 participants)</div></li><li id="ch2.lt255" class="half_rhythm"><div>Group non-directive supportive therapy compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 172 participants)</div></li><li id="ch2.lt256" class="half_rhythm"><div>Relaxation compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 49 participants)</div></li></ul></p><p>The following psychological interventions or controls were effective at reducing depression symptoms compared to an intervention:
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<ul id="ch2.l95"><li id="ch2.lt257" class="half_rhythm"><div>Usual care compared to group CBT (moderate quality evidence from 2 RCTs with 650 participants)</div></li><li id="ch2.lt258" class="half_rhythm"><div>Group CBT compared to guided self-help (moderate quality evidence from 1 RCT with 169 participants)</div></li><li id="ch2.lt259" class="half_rhythm"><div>Group mindfulness compared to group CBT (very low quality evidence from 1 RCT with 33 participants)</div></li><li id="ch2.lt260" class="half_rhythm"><div>Group non-directive supportive therapy compared to guided self-help (moderate quality evidence from 1 RCT with 168 participants)</div></li><li id="ch2.lt261" class="half_rhythm"><div>Group IPT compared to group non-directive supportive therapy (moderate quality evidence from 3 RCTs with 280 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate depression symptoms between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l96"><li id="ch2.lt262" class="half_rhythm"><div>Individual CBT compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 299 participants)</div></li><li id="ch2.lt263" class="half_rhythm"><div>Individual CBT compared to usual care (very low quality evidence from 2 RCTs with 28 participants)</div></li><li id="ch2.lt264" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 110 participants)</div></li><li id="ch2.lt265" class="half_rhythm"><div>Computer CBT compared to attention control (high quality evidence from 3 RCTs with 191 participants)</div></li><li id="ch2.lt266" class="half_rhythm"><div>Computer CBT compared to usual care (high quality evidence from 1 RCT with 187 participants)</div></li><li id="ch2.lt267" class="half_rhythm"><div>Computer CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 107 participants)</div></li><li id="ch2.lt268" class="half_rhythm"><div>Group CBT compared to attention control (moderate quality evidence from 3 RCTs with 733 participants)</div></li><li id="ch2.lt269" class="half_rhythm"><div>Group CBT compared to group non-directive supportive therapy (moderate quality evidence from 1 RCT with 177 participants)</div></li><li id="ch2.lt270" class="half_rhythm"><div>Group CBT compared to relaxation (moderate quality evidence from 2 RCTs with 45 participants)</div></li><li id="ch2.lt271" class="half_rhythm"><div>Group CBT compared to self-modelling (moderate quality evidence from 1 RCT with 34 participants)</div></li><li id="ch2.lt272" class="half_rhythm"><div>Group CBT compared to computer CBT (high quality evidence from 1 RCT with 101 participants)</div></li><li id="ch2.lt273" class="half_rhythm"><div>Group CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 106 participants)</div></li><li id="ch2.lt274" class="half_rhythm"><div>Group CBT and computer CBT compared to attention control (high quality evidence from 1 RCT with 107 participants)</div></li><li id="ch2.lt275" class="half_rhythm"><div>Family therapy compared to usual care (moderate quality evidence from 1 RCT with 66 participants)</div></li><li id="ch2.lt276" class="half_rhythm"><div>Guided self-help compared to waiting list/no treatment (moderate evidence from 1 RCT with 164 participants</div></li><li id="ch2.lt277" class="half_rhythm"><div>Relaxation compared to self-modelling (moderate quality evidence from 1 RCT with 34 participants)</div></li><li id="ch2.lt278" class="half_rhythm"><div>Self-modelling compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 34 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.2.2.1"><h5>Sensitivity analysis removing studies at high risk of bias</h5><p>This sensitivity analysis showed similar results for depression symptoms at ≤6 months with or without RCTs at high risk of bias (individual CBT compared to waiting list/no treatment; individual CBT compared to usual care; computer CBT compared to attention control).</p></div><div id="ch2.s1.1.10.1.2.2.2"><h5>Sensitivity analysis removing studies with a complex attention control</h5><p>This sensitivity analysis showed similar results for depression symptoms at ≤6 months with or without RCTs with a complex attention control (computer CBT compared to attention control).</p></div></div><div id="ch2.s1.1.10.1.2.3"><h5>Depression symptoms at >6 to ≤18 months</h5><p>The following psychological interventions were effective at reducing depression symptoms compared a control:
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<ul id="ch2.l97"><li id="ch2.lt279" class="half_rhythm"><div>Group non-directive supportive therapy compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 172 participants)</div></li><li id="ch2.lt280" class="half_rhythm"><div>Computer CBT compared to attention control (high quality evidence from 2 RCTs with 352 participants)</div></li></ul></p><p>The following psychological interventions were effective at reducing depression symptoms compared to another intervention:
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<ul id="ch2.l98"><li id="ch2.lt281" class="half_rhythm"><div>Computer CBT compared to group CBT (high quality evidence from 1 RCT with 101 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate depression symptoms between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l99"><li id="ch2.lt282" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 110 participants)</div></li><li id="ch2.lt283" class="half_rhythm"><div>Computer CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 107 participants)</div></li><li id="ch2.lt284" class="half_rhythm"><div>Group CBT compared to attention control (high quality evidence from 1 RCT with 101 participants)</div></li><li id="ch2.lt285" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 144 participants)</div></li><li id="ch2.lt286" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 2 RCTs with 182 participants)</div></li><li id="ch2.lt287" class="half_rhythm"><div>Group CBT compared to guided self-help (moderate quality evidence from 1 RCT with 169 participants)</div></li><li id="ch2.lt288" class="half_rhythm"><div>Group CBT compared to group non-directive supportive therapy (moderate quality evidence from 1 RCT with 177 participants)</div></li><li id="ch2.lt289" class="half_rhythm"><div>Group CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 106 participants)</div></li><li id="ch2.lt290" class="half_rhythm"><div>Group CBT and computer CBT compared to attention control (high quality evidence from 1 RCT with 107 participants)</div></li><li id="ch2.lt291" class="half_rhythm"><div>Guided self-help compared to waiting list/no treatment (moderate evidence from 1 RCT with 164 participants</div></li><li id="ch2.lt292" class="half_rhythm"><div>Group IPT compared to group non-directive supportive therapy (moderate quality evidence from 3 RCTs with 245 participants)</div></li><li id="ch2.lt293" class="half_rhythm"><div>Group non-directive supportive therapy compared to guided self-help (Moderate quality evidence from 1 RCT with 168 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.2.3.1"><h5>Sensitivity analysis removing studies with a complex attention control</h5><p>This sensitivity analysis showed similar results for depression symptoms at >6 to ≤18 months with or without RCTs with a complex attention control (computer CBT compared to attention control).</p></div></div><div id="ch2.s1.1.10.1.2.4"><h5>Functional status at post-treatment</h5><p>The following psychological interventions could not differentiate functional status between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l100"><li id="ch2.lt294" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 2 RCTs with 204 participants)</div></li><li id="ch2.lt295" class="half_rhythm"><div>Group IPT compared to group non-directive supportive therapy (very low quality evidence from 3 RCTs with 280 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.2.4.1"><h5>Subgroup analysis with comorbidities</h5><p>The following interventions were effective at improving functional status compared to a control in young people with mild depression and irritable bowel syndrome:
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<ul id="ch2.l101"><li id="ch2.lt296" class="half_rhythm"><div>Individual CBT compared to usual care (low quality evidence from 1 RCT with 40 participants)</div></li></ul></p></div></div><div id="ch2.s1.1.10.1.2.5"><h5>Functional status at ≤6 months</h5><p>The following psychological interventions could not differentiate functional status between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l102"><li id="ch2.lt297" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 112 participants)</div></li><li id="ch2.lt298" class="half_rhythm"><div>Group IPT compared to group non-directive supportive therapy (very low quality evidence from 3 RCTs with 267 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.2.5.1"><h5>Subgroup analysis with comorbidities</h5><p>The following interventions were effective at improving functional status compared to a control in young people with mild depression and irritable bowel syndrome:
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<ul id="ch2.l103"><li id="ch2.lt299" class="half_rhythm"><div>Individual CBT compared to usual care (low quality evidence from 1 RCT with 35 participants)</div></li></ul></p></div></div><div id="ch2.s1.1.10.1.2.6"><h5>Functional status at >6 to ≤18 months</h5><p>The following psychological interventions could not differentiate functional status between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l104"><li id="ch2.lt300" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 2 RCTs with 182 participants)</div></li><li id="ch2.lt301" class="half_rhythm"><div>Group IPT compared to group non-directive supportive therapy (moderate quality evidence from 2 RCTs with 203 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.2.6.1"><h5>Subgroup analysis with comorbidities</h5><p>The following psychological interventions could not differentiate functional status between young people with mild depression and irritable bowel syndrome who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l105"><li id="ch2.lt302" class="half_rhythm"><div>Individual CBT compared to usual care (low quality evidence from 1 RCT with 33 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.6.2"><h5>Remission at post-treatment</h5><p>The following psychological interventions could not differentiate risk of remission between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l106"><li id="ch2.lt303" class="half_rhythm"><div>Individual CBT compared to usual care (low quality evidence from 1 RCT with 13 participants)</div></li><li id="ch2.lt304" class="half_rhythm"><div>Computer CBT compared to attention control (high quality evidence from 1 RCT with 30 participants)</div></li><li id="ch2.lt305" class="half_rhythm"><div>Computer CBT compared to waiting list/no treatment (high quality evidence from 1 RCT with 30 participants)</div></li><li id="ch2.lt306" class="half_rhythm"><div>Family therapy compared to usual care (moderate quality evidence from 1 RCT with 26 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.6.3"><h5>Remission at ≤6 months</h5><p>The following psychological interventions could not differentiate risk of remission between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l107"><li id="ch2.lt307" class="half_rhythm"><div>Family therapy compared to usual care (moderate quality evidence from 1 RCT with 28 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.6.4"><h5>Quality of life at post-treatment</h5><p>The following psychological interventions could not differentiate quality of life between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l108"><li id="ch2.lt308" class="half_rhythm"><div>Computer CBT compared to waiting list/no treatment (high quality evidence from 1 RCT with 30 participants)</div></li><li id="ch2.lt309" class="half_rhythm"><div>Computer CBT compared to usual care (high quality evidence from 1 RCT with 187 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.6.5"><h5>Quality of life at ≤6 months</h5><p>The following psychological interventions could not differentiate quality of life between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l109"><li id="ch2.lt310" class="half_rhythm"><div>Computer CBT compared to attention control (low quality evidence from 1 RCT with 52 participants)</div></li><li id="ch2.lt311" class="half_rhythm"><div>Computer CBT compared to usual care (high quality evidence from 1 RCT with 187 participants)</div></li></ul></p></div></div><div id="ch2.s1.1.10.1.2.7"><h5>Self-harm</h5><p>The following psychological interventions could not differentiate risk of self-harm between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l110"><li id="ch2.lt312" class="half_rhythm"><div>Computer CBT compared to waiting list/no treatment (high quality evidence from 1 RCT with 30 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.2.7.1"><h5>Self-harm (thoughts)</h5><p>The following psychological interventions could not differentiate risk of self-harm (thoughts) between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l111"><li id="ch2.lt313" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 213 participants)</div></li><li id="ch2.lt314" class="half_rhythm"><div>Group CBT compared to attention control (moderate quality evidence from 1 RCT with 249 participants)</div></li></ul></p></div></div><div id="ch2.s1.1.10.1.2.8"><h5>Self-harm (deliberate)</h5><p>The following psychological interventions could not differentiate risk of self-harm (deliberate) between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l112"><li id="ch2.lt315" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 128 participants)</div></li><li id="ch2.lt316" class="half_rhythm"><div>Group CBT compared to attention control (moderate quality evidence from 1 RCT with 148 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.9"><h5>Suicide-related adverse events</h5><p>The following psychological interventions could not differentiate risk of suicide-related adverse events between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l113"><li id="ch2.lt317" class="half_rhythm"><div>Computer CBT compared to usual care (high quality evidence from 1 RCT with 187)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.10"><h5>Suicide ideation at post-treatment</h5><p>The following psychological interventions could not differentiate risk of suicide ideation between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l114"><li id="ch2.lt318" class="half_rhythm"><div>Computer CBT compared to attention control (high quality evidence from 1 RCT with 102 participants)</div></li><li id="ch2.lt319" class="half_rhythm"><div>Individual CBT compared to usual care (low quality evidence from 1 RCT with 27 participants)</div></li><li id="ch2.lt320" class="half_rhythm"><div>Computer CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 107 participants)</div></li><li id="ch2.lt321" class="half_rhythm"><div>Group CBT compared to attention control (high quality evidence from 1 RCT with 101 participants)</div></li><li id="ch2.lt322" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 84 participants)</div></li><li id="ch2.lt323" class="half_rhythm"><div>Group CBT compared to computer CBT (high quality evidence from 1 RCT with 101 participants)</div></li><li id="ch2.lt324" class="half_rhythm"><div>Group CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 106 participants)</div></li><li id="ch2.lt325" class="half_rhythm"><div>Group CBT and computer CBT compared to attention control (high quality evidence from 1 RCT with 107 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.11"><h5>Suicide ideation at ≤6 months</h5><p>The following psychological interventions were effective at reducing suicide ideation compared to a control:
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<ul id="ch2.l115"><li id="ch2.lt326" class="half_rhythm"><div>Family therapy compared to usual care (moderate quality evidence from 1 RCT with 28 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.12"><h5>Suicide ideation at >6 to ≤18 months</h5><p>The following psychological interventions were effective at reducing suicide ideation compared to a control:
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<ul id="ch2.l116"><li id="ch2.lt327" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 72 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.2.13"><h5>Discontinuation for any reason at end point</h5><p>The following psychological interventions or controls were effective at reducing discontinuation compared to an intervention:
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<ul id="ch2.l117"><li id="ch2.lt328" class="half_rhythm"><div>Attention control compared to group CBT (moderate quality evidence from 3 RCTs with 182 participants)</div></li><li id="ch2.lt329" class="half_rhythm"><div>Waiting list/no treatment compared to group non-directive supportive therapy (moderate quality evidence from 1 RCT with 159 participants)</div></li><li id="ch2.lt330" class="half_rhythm"><div>Waiting list/no treatment compared to guided self-help (moderate quality evidence from 1 RCT with 164 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate risk of discontinuation between young people with mild depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l118"><li id="ch2.lt331" class="half_rhythm"><div>Individual CBT compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 362 participants)</div></li><li id="ch2.lt332" class="half_rhythm"><div>Individual CBT compared to usual care (low quality evidence from 3 RCTs with 367 participants)</div></li><li id="ch2.lt333" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 110 participants)</div></li><li id="ch2.lt334" class="half_rhythm"><div>Computer CBT compared to attention control (very low quality evidence from 4 RCTs with 475 participants)</div></li><li id="ch2.lt335" class="half_rhythm"><div>Computer CBT compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 142 participants)</div></li><li id="ch2.lt336" class="half_rhythm"><div>Computer CBT compared to usual care (high quality evidence from 1 RCT with 185 participants)</div></li><li id="ch2.lt337" class="half_rhythm"><div>Computer CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 104 participants)</div></li><li id="ch2.lt338" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (low quality evidence from 4 RCTs with 381 participants)</div></li><li id="ch2.lt339" class="half_rhythm"><div>Group CBT compared to usual care (very low quality evidence from 2 RCTs with 840 participants)</div></li><li id="ch2.lt340" class="half_rhythm"><div>Group CBT compared to guided self-help (moderate quality evidence from 1 RCT with 41 participants)</div></li><li id="ch2.lt341" class="half_rhythm"><div>Group CBT compared to group non-directive supportive therapy (moderate quality evidence from 1 RCT with 155 participants)</div></li><li id="ch2.lt342" class="half_rhythm"><div>Group CBT compared to relaxation (moderate quality evidence from 1 RCT with 20 participants)</div></li><li id="ch2.lt343" class="half_rhythm"><div>Group CBT compared to group CBT and computer CBT (high quality evidence from 1 RCT with 100 participants)</div></li><li id="ch2.lt344" class="half_rhythm"><div>Group CBT and computer CBT compared to attention control (high quality evidence from 1 RCT with 103 participants)</div></li><li id="ch2.lt345" class="half_rhythm"><div>Group mindfulness compared to group CBT (very low quality evidence from 1 RCT with 28 participants)</div></li><li id="ch2.lt346" class="half_rhythm"><div>Guided self-help compared to attention control (low quality evidence from 1 RCT with 30 participants)</div></li><li id="ch2.lt347" class="half_rhythm"><div>Group IPT compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 209 participants)</div></li><li id="ch2.lt348" class="half_rhythm"><div>Group IPT compared to group non-directive supportive therapy (moderate quality evidence from 3 RCTs with 280 participants)</div></li><li id="ch2.lt349" class="half_rhythm"><div>Group IPT compared to creative play therapy (moderate quality evidence form 1 RCT with 210 participants)</div></li><li id="ch2.lt350" class="half_rhythm"><div>Group non-directive supportive therapy compared to guided self-help (moderate quality evidence from 1 RCT with 45 participants)</div></li><li id="ch2.lt351" class="half_rhythm"><div>Relaxation compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 21 participants)</div></li><li id="ch2.lt352" class="half_rhythm"><div>Creative play therapy compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 209 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.2.13.1"><h5>Sensitivity analysis removing studies at high risk of bias</h5><p>This sensitivity analysis showed similar results for discontinuation for any reason at end point with or without RCTs at high risk of bias (individual CBT compared to usual care; computer CBT compared to attention control).</p></div><div id="ch2.s1.1.10.1.2.13.2"><h5>Sensitivity analysis removing studies with a complex attention control</h5><p>This sensitivity analysis showed similar results for discontinuation for any reason at end point with or without RCTs with a complex attention control (computer CBT compared to attention control).</p></div></div></div><div id="ch2.s1.1.10.1.3"><h5>Moderate to severe depression in age 5–11 year olds</h5><div id="ch2.s1.1.10.1.3.1"><h5>Depression symptoms at post-treatment</h5><p>The following psychological interventions were effective at reducing depression symptoms compared to another psychological intervention:
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<ul id="ch2.l119"><li id="ch2.lt353" class="half_rhythm"><div>Family therapy compared to psychodynamic psychotherapy (moderate quality evidence from 1 RCT with 72 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate depression symptoms between children with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l120"><li id="ch2.lt354" class="half_rhythm"><div>Individual CBT compared to usual care (low quality evidence from 1 RCT with 44 participants)</div></li><li id="ch2.lt355" class="half_rhythm"><div>Group CBT compared to attention control (moderate quality evidence from 1 RCT with 21 participants)</div></li><li id="ch2.lt356" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 21 participants)</div></li><li id="ch2.lt357" class="half_rhythm"><div>Family psychoeducation with CBT compared to pill placebo (moderate quality evidence from 1 RCT with 37 participants)</div></li><li id="ch2.lt358" class="half_rhythm"><div>Family based IPT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 38 participants)</div></li><li id="ch2.lt359" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 134 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.3.2"><h5>Depression symptoms at ≤6 months</h5><p>The following psychological interventions could not differentiate depression symptoms between children with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l121"><li id="ch2.lt360" class="half_rhythm"><div>Group CBT compared to attention control (moderate quality evidence from 1 RCT with 21 participants)</div></li><li id="ch2.lt361" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 21 participants)</div></li><li id="ch2.lt362" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family therapy (moderate quality evidence from 1 RCT with 72 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.3.3"><h5>Functional status at post-treatment</h5><p>The following psychological interventions could not differentiate functional status between children with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l122"><li id="ch2.lt363" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 134 participants)</div></li><li id="ch2.lt364" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family therapy (moderate quality evidence from 1 RCT with 72 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.3.4"><h5>Functional status at ≤6 months</h5><p>The following psychological interventions could not differentiate functional status between children with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l123"><li id="ch2.lt365" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family therapy (moderate quality evidence from 1 RCT with 72 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.3.5"><h5>Remission at post-treatment</h5><p>The following psychological interventions could not differentiate remission between children with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l124"><li id="ch2.lt366" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCTs with 134 participants)</div></li><li id="ch2.lt367" class="half_rhythm"><div>Family based IPT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 38 participants)</div></li><li id="ch2.lt368" class="half_rhythm"><div>Family psychoeducation with CBT compared to pill placebo (moderate quality evidence from 1 RCT with 37 participants)</div></li><li id="ch2.lt369" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family therapy (moderate quality evidence from 1 RCT with 72 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.3.6"><h5>Remission at ≤6 months</h5><p>The following psychological interventions were effective at increasing the number of people in remission compared to another psychological intervention:
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<ul id="ch2.l125"><li id="ch2.lt370" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family therapy (moderate quality evidence from 1 RCT with 72 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.3.7"><h5>Discontinuation for any reason at end point</h5><p>The following psychological interventions could not differentiate risk of discontinuation between children with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l126"><li id="ch2.lt371" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCTs with 134 participants)</div></li><li id="ch2.lt372" class="half_rhythm"><div>Family based IPT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 40 participants)</div></li><li id="ch2.lt373" class="half_rhythm"><div>Family psychoeducation with CBT compared to pill placebo (moderate quality evidence from 1 RCT with 37 participants)</div></li><li id="ch2.lt374" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family therapy (moderate quality evidence from 1 RCT with 72 participants)</div></li></ul></p></div></div><div id="ch2.s1.1.10.1.4"><h5>Moderate to severe depression in age 12–18 year olds</h5><div id="ch2.s1.1.10.1.4.1"><h5>Depression symptoms at post-treatment</h5><p>The following psychological interventions were effective at reducing depression symptoms compared to a control:
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<ul id="ch2.l127"><li id="ch2.lt375" class="half_rhythm"><div>Individual CBT compared to waiting list/no treatment (very low quality evidence from 3 RCTs with 194 participants)</div></li><li id="ch2.lt376" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 102 participants)</div></li><li id="ch2.lt377" class="half_rhythm"><div>Group CBT and parent sessions compared to waiting list/no treatment (low quality evidence from 2 RCTs with 99 participants)</div></li><li id="ch2.lt378" class="half_rhythm"><div>Online guided self-help compared to waiting list/no treatment (moderate quality of evidence from 1 RCT with 31 participants)</div></li><li id="ch2.lt379" class="half_rhythm"><div>Computer CBT compared to attention control (low quality evidence from 1 RCT with 70 participants)</div></li></ul></p><p>The following psychological interventions were effective at reducing depression symptoms compared to another psychological intervention:
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<ul id="ch2.l128"><li id="ch2.lt380" class="half_rhythm"><div>Individual CBT compared to family therapy (moderate quality evidence from 1 RCT with 64 participants)</div></li><li id="ch2.lt381" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention (high quality evidence from 1 RCT with 209 participants)</div></li><li id="ch2.lt382" class="half_rhythm"><div>Individual CBT compared to relaxation (moderate quality evidence from 1 RCT with 48 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate depression symptoms between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l129"><li id="ch2.lt383" class="half_rhythm"><div>Individual CBT compared to pill placebo (low quality evidence from 1 RCT with 223 participants)</div></li><li id="ch2.lt384" class="half_rhythm"><div>Individual CBT compared to usual care (very low quality evidence from 3 RCTs with 220 participants)</div></li><li id="ch2.lt385" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 64 participants)</div></li><li id="ch2.lt386" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy (high quality evidence from 1 RCT with 213 participants)</div></li><li id="ch2.lt387" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 86 participants)</div></li><li id="ch2.lt388" class="half_rhythm"><div>Group CBT compared to group CBT and parent sessions (low quality evidence from 2 RCTs with 109 participants)</div></li><li id="ch2.lt389" class="half_rhythm"><div>Family therapy compared to attention control (moderate quality evidence from 1 RCT with 32 participants)</div></li><li id="ch2.lt390" class="half_rhythm"><div>Family therapy compared to usual care (high quality evidence from 2 RCTs with 78 participants)</div></li><li id="ch2.lt391" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 62 participants)</div></li><li id="ch2.lt392" class="half_rhythm"><div>IPT-A compared to waiting list (moderate quality evidence from 1 RCT with 37 participants)</div></li><li id="ch2.lt393" class="half_rhythm"><div>IPT-A compared to monitoring (moderate quality evidence from 1 RCT with 48 participants)</div></li><li id="ch2.lt394" class="half_rhythm"><div>IPT-A compared to usual care (moderate quality evidence from 1 RCT with 63 participants)</div></li><li id="ch2.lt395" class="half_rhythm"><div>IPT-A compared to individual CBT (moderate quality evidence from 1 RCT with 40 participants)</div></li><li id="ch2.lt396" class="half_rhythm"><div>IPT-A compared to IPT-A and parent sessions (moderate quality evidence from 1 RCT with 15 participants)</div></li><li id="ch2.lt397" class="half_rhythm"><div>IPT-A compared to group IPT (moderate quality evidence from 1 RCT with 39 participants)</div></li><li id="ch2.lt398" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention (high quality evidence from 1 RCT with 214 participants)</div></li><li id="ch2.lt399" class="half_rhythm"><div>Behaviour activation compared to usual care (low quality evidence from 1 RCT with 60 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.4.1.1"><h5>Sensitivity analysis removing studies at high risk of bias</h5><p>This sensitivity analysis showed similar results for depression symptoms at post-treatment with or without RCTs at high risk of bias (individual CBT compared to usual care).</p></div></div><div id="ch2.s1.1.10.1.4.2"><h5>Depression symptoms at ≤6 months</h5><p>The following psychological interventions could not differentiate depression symptoms between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l130"><li id="ch2.lt400" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li><li id="ch2.lt401" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy (high quality evidence from 1 RCT with 221 participants)</div></li><li id="ch2.lt402" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention (high quality evidence from 1 RCT with 216 participants)</div></li><li id="ch2.lt403" class="half_rhythm"><div>Individual CBT compared to relaxation (moderate quality evidence from 1 RCT with 48 participants)</div></li><li id="ch2.lt404" class="half_rhythm"><div>Group CBT compared to group CBT and parent sessions (moderate quality evidence from 1 RCT with 30 participants)</div></li><li id="ch2.lt405" class="half_rhythm"><div>Family therapy compared to usual care (high quality evidence from 1 RCT with 64 participants)</div></li><li id="ch2.lt406" class="half_rhythm"><div>IPT-A compared to individual CBT (moderate quality evidence from 1 RCT with 23 participants)</div></li><li id="ch2.lt407" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention (high quality evidence from 1 RCT with 115 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.3"><h5>Depression symptoms at ≥6 to ≤18 months</h5><p>The following psychological interventions could not differentiate depression symptoms between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l131"><li id="ch2.lt408" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li><li id="ch2.lt409" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy (high quality evidence from 1 RCT with 237 participants)</div></li><li id="ch2.lt410" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention (high quality evidence from 1 RCT with 239 participants)</div></li><li id="ch2.lt411" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 73 participants)</div></li><li id="ch2.lt412" class="half_rhythm"><div>Group CBT compared to group CBT and parent sessions (moderate quality evidence from 1 RCT with 29 participants)</div></li><li id="ch2.lt413" class="half_rhythm"><div>IPT-A compared to group IPT (moderate quality evidence from 1 RCT with 39 participants)</div></li><li id="ch2.lt414" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention (high quality evidence from 1 RCT with 130 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.4"><h5>Functional status at post-treatment</h5><p>The following psychological interventions were effective at improving functional status compared to a control:
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<ul id="ch2.l132"><li id="ch2.lt415" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li><li id="ch2.lt416" class="half_rhythm"><div>Group CBT and parent sessions compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 59 participants)</div></li><li id="ch2.lt417" class="half_rhythm"><div>IPT-A compared to usual care (moderate quality evidence from 1 RCT with 58 participants)</div></li></ul></p><p>The following psychological interventions or controls were effective at improving functional status compared to an intervention:
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<ul id="ch2.l133"><li id="ch2.lt418" class="half_rhythm"><div>IPT-A and parent sessions compared to IPT-A (moderate quality evidence from 1 RCT with 15 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate functional status between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l134"><li id="ch2.lt419" class="half_rhythm"><div>Individual CBT compared to pill placebo (low quality evidence from 1 RCT with 223 participants)</div></li><li id="ch2.lt420" class="half_rhythm"><div>Individual CBT compared to family therapy (moderate quality evidence from 1 RCT with 66 participants)</div></li><li id="ch2.lt421" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 68 participants)</div></li><li id="ch2.lt422" class="half_rhythm"><div>Individual CBT compared to relaxation (moderate quality evidence from 1 RCT with 53 participants)</div></li><li id="ch2.lt423" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 64 participants)</div></li><li id="ch2.lt424" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 86 participants)</div></li><li id="ch2.lt425" class="half_rhythm"><div>Group CBT compared to group CBT and parent sessions (moderate quality evidence from 1 RCT with 69 participants)</div></li><li id="ch2.lt426" class="half_rhythm"><div>IPT-A compared to group IPT (moderate quality evidence from 1 RCT with 39 participants)</div></li><li id="ch2.lt427" class="half_rhythm"><div>Behaviour activation compared to usual care (low quality evidence from 1 RCT with 60 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.5"><h5>Functional status at ≤6 months</h5><p>The following psychological interventions could not differentiate functional status between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l135"><li id="ch2.lt428" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li><li id="ch2.lt429" class="half_rhythm"><div>Individual CBT compared to relaxation (moderate quality evidence from 1 RCT with 48 participants)</div></li><li id="ch2.lt430" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 53 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.6"><h5>Functional status at ≥6 to ≤18 months</h5><p>The following psychological interventions could not differentiate functional status between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l136"><li id="ch2.lt431" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li><li id="ch2.lt432" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 73 participants)</div></li><li id="ch2.lt433" class="half_rhythm"><div>IPT-A compared to group IPT (moderate quality evidence from 1 RCT with 39 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.7"><h5>Remission at post-treatment</h5><p>The following psychological interventions were effective at increasing the number of people in remission compared to a control:
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<ul id="ch2.l137"><li id="ch2.lt434" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 30 participants)</div></li><li id="ch2.lt435" class="half_rhythm"><div>Computer CBT compared to attention control (low quality evidence from 1 RCT with 70 participants)</div></li></ul></p><p>The following psychological interventions were effective at increasing the number of people in remission compared to another intervention:
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<ul id="ch2.l138"><li id="ch2.lt436" class="half_rhythm"><div>Individual CBT compared to family therapy (moderate quality evidence from 1 RCT with 66 participants)</div></li><li id="ch2.lt437" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 124 participants)</div></li><li id="ch2.lt438" class="half_rhythm"><div>Individual CBT compared to relaxation (moderate quality evidence from 1 RCT with 48 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate risk of remission between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l139"><li id="ch2.lt439" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 43 participants)</div></li><li id="ch2.lt440" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 3 RCTs with 124 participants)</div></li><li id="ch2.lt441" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy (high quality evidence from 1 RCT with 97 participants)</div></li><li id="ch2.lt442" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention (high quality evidence from 1 RCT with 313 participants)</div></li><li id="ch2.lt443" class="half_rhythm"><div>Group CBT compared to group CBT and parent sessions (moderate quality evidence from 1 RCT with 35 participants)</div></li><li id="ch2.lt444" class="half_rhythm"><div>Group CBT and parent sessions compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 33 participants)</div></li><li id="ch2.lt445" class="half_rhythm"><div>Family therapy compared to attention control (moderate quality evidence from 1 RCT with 32 participants)</div></li><li id="ch2.lt446" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 64 participants)</div></li><li id="ch2.lt447" class="half_rhythm"><div>IPT-A compared to group IPT (moderate quality evidence from 1 RCT with 39 participants)</div></li><li id="ch2.lt448" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention (high quality evidence from 1 RCT with 315 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.4.7.1"><h5>Subgroup analysis with comorbidities</h5><p>The following psychological interventions could not differentiate risk of remission between young people with moderate to severe depression and irritable bowel syndrome who were offered psychological interventions compared to other psychological interventions or controls
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<ul id="ch2.l140"><li id="ch2.lt449" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 217 participants)</div></li></ul></p></div></div><div id="ch2.s1.1.10.1.4.8"><h5>Remission at <6 months</h5><p>The following psychological interventions could not differentiate risk of remission between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l141"><li id="ch2.lt450" class="half_rhythm"><div>Individual CBT compared to relaxation (moderate quality evidence from 1 RCT with 43 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.9"><h5>Remission at >6 to ≤18 months</h5><p>The following psychological interventions could not differentiate risk of remission between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l142"><li id="ch2.lt451" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 56 participants)</div></li><li id="ch2.lt452" class="half_rhythm"><div>IPT-A compared to group IPT (moderate quality evidence from 1 RCT with 39 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.10"><h5>Quality of life at post-treatment</h5><p>The following psychological interventions were effective at improving quality of life compared to a control:
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<ul id="ch2.l143"><li id="ch2.lt453" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate quality of life between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l144"><li id="ch2.lt454" class="half_rhythm"><div>Individual CBT compared to pill placebo (low quality evidence from 1 RCT with 163 participants)</div></li><li id="ch2.lt455" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy (high quality evidence from 1 RCT with 169 participants)</div></li><li id="ch2.lt456" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention (high quality evidence from 1 RCT with 169 participants)</div></li><li id="ch2.lt457" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention (high quality evidence from 1 RCT with 176 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.11"><h5>Quality of life at ≤6 months</h5><p>The following psychological interventions were effective at improving quality of life compared to usual care:
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<ul id="ch2.l145"><li id="ch2.lt458" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate quality of life between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l146"><li id="ch2.lt459" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy (high quality evidence from 1 RCT with 169 participants)</div></li><li id="ch2.lt460" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention (high quality evidence from 1 RCT with 169 participants)</div></li><li id="ch2.lt461" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention (high quality evidence from 1 RCT with 171 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.12"><h5>Quality of life at >6 to ≤18 months</h5><p>The following psychological interventions could not differentiate quality of life between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l147"><li id="ch2.lt462" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li><li id="ch2.lt463" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy (high quality evidence from 1 RCT with 177 participants)</div></li><li id="ch2.lt464" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention (high quality evidence from 1 RCT with 190 participants)</div></li><li id="ch2.lt465" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention (high quality evidence from 1 RCT with 183 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.13"><h5>Suicide-related adverse events</h5><p>The following psychological interventions could not differentiate risk of suicide-related adverse events between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l148"><li id="ch2.lt466" class="half_rhythm"><div>Individual CBT compared to pill placebo (low quality evidence from 1 RCT with 123 participants</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.14"><h5>Suicide ideation at post-treatment</h5><p>The following psychological interventions were effective at reducing suicide ideation compared to a control:
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<ul id="ch2.l149"><li id="ch2.lt467" class="half_rhythm"><div>Individual CBT compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 30 participants)</div></li><li id="ch2.lt468" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate risk of suicide ideation between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l150"><li id="ch2.lt469" class="half_rhythm"><div>Individual CBT compared to pill placebo (low quality evidence from 1 RCT with 123 participants)</div></li><li id="ch2.lt470" class="half_rhythm"><div>Individual CBT compared to family therapy (moderate quality evidence from 1 RCT with 66 participants)</div></li><li id="ch2.lt471" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 68 participants)</div></li><li id="ch2.lt472" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 86 participants)</div></li><li id="ch2.lt473" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 64 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.15"><h5>Suicide ideation at ≤6 months</h5><p>The following psychological interventions could not differentiate risk of suicide ideation between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l151"><li id="ch2.lt474" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.16"><h5>Suicide ideation at >6 to ≤18 months</h5><p>The following psychological interventions could not differentiate risk of suicide ideation between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l152"><li id="ch2.lt475" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 1 RCT with 212 participants)</div></li><li id="ch2.lt476" class="half_rhythm"><div>Group CBT compared to usual care (moderate quality evidence from 1 RCT with 73 participants)</div></li><li id="ch2.lt477" class="half_rhythm"><div>Group CBT compared to group CBT and parent sessions (moderate quality evidence from 1 RCT with 73 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.17"><h5>Discontinuation for any reason at end point</h5><p>The following psychological interventions were effective at reducing discontinuation compared to a control:
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<ul id="ch2.l153"><li id="ch2.lt478" class="half_rhythm"><div>Behavioural activation compared to usual care (low quality evidence from 1 RCT with 53 participants)</div></li><li id="ch2.lt479" class="half_rhythm"><div>IPT-A compared to monitoring (moderate quality evidence from 1 RCT with 48 participants)</div></li></ul></p><p>The following psychological interventions were effective at reducing discontinuation compared to an intervention:
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<ul id="ch2.l154"><li id="ch2.lt480" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention (high quality evidence from 1 RCT with 289 participants)</div></li></ul></p><p>The following psychological interventions could not differentiate risk of discontinuation between young people with moderate to severe depression who were offered psychological interventions compared to other psychological interventions or controls:
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<ul id="ch2.l155"><li id="ch2.lt481" class="half_rhythm"><div>Individual CBT compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 48 participants)</div></li><li id="ch2.lt482" class="half_rhythm"><div>Individual CBT compared to pill placebo (low quality evidence from 1 RCT with 123 participants)</div></li><li id="ch2.lt483" class="half_rhythm"><div>Individual CBT compared to usual care (moderate quality evidence from 3 RCTs with 321 participants)</div></li><li id="ch2.lt484" class="half_rhythm"><div>Individual CBT compared to family therapy (moderate quality evidence from 1 RCT with 72 participants)</div></li><li id="ch2.lt485" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 2 RCTs with 128 participants)</div></li><li id="ch2.lt486" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy (high quality evidence from 1 RCT with 178 participants)</div></li><li id="ch2.lt487" class="half_rhythm"><div>Individual CBT compared to relaxation (moderate quality evidence from 1 RCT with 53 participants)</div></li><li id="ch2.lt488" class="half_rhythm"><div>Computer CBT compared to attention control (low quality evidence from 1 RCT with 70 participants)</div></li><li id="ch2.lt489" class="half_rhythm"><div>Group CBT compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 121 participants)</div></li><li id="ch2.lt490" class="half_rhythm"><div>Group CBT and parent sessions compared to waiting list/no treatment (moderate quality evidence from 2 RCTs with 116 participants)</div></li><li id="ch2.lt491" class="half_rhythm"><div>Group CBT compared to group CBT and parent sessions (moderate quality evidence from 2 RCTs with 127 participants)</div></li><li id="ch2.lt492" class="half_rhythm"><div>Family therapy compared to usual care (moderate quality evidence from 2 RCTs with 73 participants)</div></li><li id="ch2.lt493" class="half_rhythm"><div>Family therapy compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 70 participants)</div></li><li id="ch2.lt494" class="half_rhythm"><div>Online guided self-help compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 31 participants)</div></li><li id="ch2.lt495" class="half_rhythm"><div>IPT-A compared to waiting list/no treatment (moderate quality evidence from 1 RCT with 46 participants)</div></li><li id="ch2.lt496" class="half_rhythm"><div>IPT-A compared to usual care (moderate quality evidence from 1 RCT with 63 participants)</div></li><li id="ch2.lt497" class="half_rhythm"><div>IPT-A compared to individual CBT (moderate quality evidence from 1 RCT with 48 participants)</div></li><li id="ch2.lt498" class="half_rhythm"><div>IPT-A compared to IPT-A and parent sessions (moderate quality evidence from 1 RCT with 15 participants)</div></li><li id="ch2.lt499" class="half_rhythm"><div>Group IPT compared to IPT-A (moderate quality evidence from 1 RCT with 39 participants)</div></li><li id="ch2.lt500" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention (high quality evidence from 1 RCT with 283 participants)</div></li></ul></p><div id="ch2.s1.1.10.1.4.17.1"><h5>Subgroup analysis with comorbidities</h5><p>The following psychological interventions could not differentiate risk of discontinuation between young people with moderate to severe depression and irritable bowel syndrome who were offered psychological interventions compared to other psychological interventions or controls
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<ul id="ch2.l156"><li id="ch2.lt501" class="half_rhythm"><div>Individual CBT compared to non-directive supportive therapy (moderate quality evidence from 1 RCT with 191 participants)</div></li></ul></p></div><div id="ch2.s1.1.10.1.4.17.2"><h5>Sensitivity analysis removing studies at high risk of bias</h5><p>This sensitivity analysis showed similar results for discontinuation for any reason at end point with or without RCTs at high risk of bias (individual CBT compared to usual care).</p></div></div></div></div><div id="ch2.s1.1.10.2"><h5>Network meta-analysis</h5><p>The format of the evidence statements is described in <a href="#ch2.appb">appendix B</a> and summaries of the results of the NMA are presented in <a href="#ch2.appg">appendix G</a>.</p><div id="ch2.s1.1.10.2.1"><h5>Mild depression in 12–18 year olds</h5><div id="ch2.s1.1.10.2.1.1"><h5>Depression symptoms at post-treatment, mild depression in 12 to 18 years old</h5><p>Very low quality evidence from 1 network meta-analysis with 25 RCTs containing 3,213 participants found that the following psychological interventions were effective at reducing depression symptoms compared to waiting list/no treatment:
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<ul id="ch2.l157"><li id="ch2.lt502" class="half_rhythm"><div>Group CBT</div></li><li id="ch2.lt503" class="half_rhythm"><div>Relaxation</div></li><li id="ch2.lt504" class="half_rhythm"><div>Guided self-help</div></li><li id="ch2.lt505" class="half_rhythm"><div>Computer CBT</div></li><li id="ch2.lt506" class="half_rhythm"><div>Group CBT + computer CBT</div></li><li id="ch2.lt507" class="half_rhythm"><div>Family therapy</div></li><li id="ch2.lt508" class="half_rhythm"><div>Group IPT</div></li></ul></p><p>The following psychological interventions were effective reducing depression symptoms:
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<ul id="ch2.l158"><li id="ch2.lt509" class="half_rhythm"><div>Group IPT better than group NDST</div></li></ul></p><p>The evidence could not differentiate depression symptoms between the remaining comparators.</p></div><div id="ch2.s1.1.10.2.1.2"><h5>Depression symptoms at ≤6 months, mild depression in 12 to 18 years old</h5><p>Low quality evidence from 1 network meta-analysis with 21 RCTs containing 2,852 participants found that the following psychological interventions were effective at reducing depression symptoms compared to waiting list/no treatment:
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<ul id="ch2.l159"><li id="ch2.lt510" class="half_rhythm"><div>Group CBT</div></li><li id="ch2.lt511" class="half_rhythm"><div>Group NDST</div></li><li id="ch2.lt512" class="half_rhythm"><div>Individual CBT</div></li><li id="ch2.lt513" class="half_rhythm"><div>Computer CBT</div></li><li id="ch2.lt514" class="half_rhythm"><div>Group CBT + computer CBT</div></li><li id="ch2.lt515" class="half_rhythm"><div>Family therapy</div></li><li id="ch2.lt516" class="half_rhythm"><div>Group IPT</div></li></ul></p><p>The following psychological interventions were effective at reducing depression symptoms compared to attention control:
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<ul id="ch2.l160"><li id="ch2.lt517" class="half_rhythm"><div>Computer CBT</div></li><li id="ch2.lt518" class="half_rhythm"><div>Group IPT</div></li></ul></p><p>The following psychological interventions were effective at reducing depression symptoms:
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|
<ul id="ch2.l161"><li id="ch2.lt519" class="half_rhythm"><div>Group CBT compared to guided self-help, NDST</div></li><li id="ch2.lt520" class="half_rhythm"><div>Group NDST compared to guided self-help, NDST</div></li><li id="ch2.lt521" class="half_rhythm"><div>Computer CBT compared to group CBT, guided self-help, individual CBT, NDST</div></li><li id="ch2.lt522" class="half_rhythm"><div>Group CBT + computer CBT compared to guided self-help, NDST</div></li><li id="ch2.lt523" class="half_rhythm"><div>Family therapy compared to guided self-help, individual CBT, NDST</div></li><li id="ch2.lt524" class="half_rhythm"><div>Group IPT compared to group CBT, guided self-help, group NDST, individual CBT, NDST</div></li><li id="ch2.lt525" class="half_rhythm"><div>Attention control compared to guided self-help, NDST</div></li><li id="ch2.lt526" class="half_rhythm"><div>Usual care compared to guided self-help, individual CBT, NDST</div></li></ul></p><p>The evidence could not differentiate depression symptoms between the remaining comparators.</p></div><div id="ch2.s1.1.10.2.1.3"><h5>Depression symptoms at >6 to ≤18 months, mild depression in 12 to 18 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 9 RCTs containing 1,417 participants found that the following psychological interventions were effective at reducing depression symptoms compared to waiting list/no treatment:
|
|
<ul id="ch2.l162"><li id="ch2.lt527" class="half_rhythm"><div>Group NDST</div></li><li id="ch2.lt528" class="half_rhythm"><div>Computer CBT</div></li><li id="ch2.lt529" class="half_rhythm"><div>Group IPT</div></li></ul></p><p>The following psychological interventions were effective at reducing depression symptoms compared to attention control:
|
|
<ul id="ch2.l163"><li id="ch2.lt530" class="half_rhythm"><div>Computer CBT</div></li></ul></p><p>The following psychological interventions were effective at reducing depression symptoms compared to usual care:
|
|
<ul id="ch2.l164"><li id="ch2.lt531" class="half_rhythm"><div>Computer CBT</div></li></ul></p><p>The following psychological interventions were effective at reducing depression symptoms:
|
|
<ul id="ch2.l165"><li id="ch2.lt532" class="half_rhythm"><div>Computer CBT compared to group CBT, guided self-help, group NDST</div></li></ul></p><p>The evidence could not differentiate depression symptoms between the remaining comparators.</p></div><div id="ch2.s1.1.10.2.1.4"><h5>Remission at post-treatment, mild depression in 12 to 18 years old</h5><p>Very low quality evidence from 1 network meta-analysis with 2 RCTs containing 87 participants found that the following psychological interventions were effective at increasing remission compared to usual care:
|
|
<ul id="ch2.l166"><li id="ch2.lt533" class="half_rhythm"><div>Individual CBT</div></li></ul></p><p>The evidence could not differentiate remission between:
|
|
<ul id="ch2.l167"><li id="ch2.lt534" class="half_rhythm"><div>Family therapy compared to individual CBT and usual care</div></li></ul></p></div><div id="ch2.s1.1.10.2.1.5"><h5>Discontinuation for any reason at end point, mild depression in 12 to 18 years old</h5><p>Low quality evidence from 1 network meta-analysis with 21 RCTs containing 3,396 participants could not differentiate discontinuation between:
|
|
<ul id="ch2.l168"><li id="ch2.lt535" class="half_rhythm"><div>Group CBT, relaxation, guided self-help, group NDST, individual CBT, NDST, computer CBT, group + computer CBT, group IPT, creative play therapy, attention control, usual care, and waiting list or no treatment</div></li></ul></p></div></div><div id="ch2.s1.1.10.2.2"><h5>Moderate to severe depression in 5–11 year olds</h5><div id="ch2.s1.1.10.2.2.1"><h5>Depression symptoms at post-treatment, moderate to severe depression in 5 to 11 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 3 RCTs containing 244 participants found that the following psychological interventions were effective at reducing depression symptoms
|
|
<ul id="ch2.l169"><li id="ch2.lt536" class="half_rhythm"><div>Family based IPT compared to psychodynamic psychotherapy</div></li><li id="ch2.lt537" class="half_rhythm"><div>Family therapy compared to psychodynamic psychotherapy</div></li></ul></p><p>The evidence could not differentiate depression symptoms between the remaining comparators.</p></div><div id="ch2.s1.1.10.2.2.2"><h5>Functional status at post-treatment, moderate to severe depression in 5 to 11 years old</h5><p>Low quality evidence from 1 network meta-analysis with 2 RCTs containing 206 participants could not differentiate functional status between:
|
|
<ul id="ch2.l170"><li id="ch2.lt538" class="half_rhythm"><div>Family therapy, NDST and psychodynamic psychotherapy</div></li></ul></p></div><div id="ch2.s1.1.10.2.2.3"><h5>Functional status at post-treatment, moderate to severe depression in 5 to 11 years old</h5><p>Low quality evidence from 1 network meta-analysis with 2 RCTs containing 206 participants could not differentiate functional status between:
|
|
<ul id="ch2.l171"><li id="ch2.lt539" class="half_rhythm"><div>Family therapy, NDST and psychodynamic psychotherapy</div></li></ul></p></div><div id="ch2.s1.1.10.2.2.4"><h5>Remission at post-treatment, moderate to severe depression in 5 to 11 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 3 RCTs containing 244 participants found that the following psychological interventions were effective at increasing remission:
|
|
<ul id="ch2.l172"><li id="ch2.lt540" class="half_rhythm"><div>Family based IPT compared to NDST</div></li></ul></p><p>The evidence could not differentiate remission between:
|
|
<ul id="ch2.l173"><li id="ch2.lt541" class="half_rhythm"><div>Family therapy compared to family based IPT, NDST</div></li><li id="ch2.lt542" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family based IPT, NDST, family therapy</div></li></ul></p></div><div id="ch2.s1.1.10.2.2.5"><h5>Discontinuation for any reason at end point, moderate to severe depression in 5 to 11 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 3 RCTs containing 246 participants found that the following psychological interventions were effective at reducing discontinuation:
|
|
<ul id="ch2.l174"><li id="ch2.lt543" class="half_rhythm"><div>NDST compared to family therapy</div></li><li id="ch2.lt544" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family therapy</div></li></ul></p><p>The evidence could not differentiate discontinuation between the remaining comparators.</p></div></div><div id="ch2.s1.1.10.2.3"><h5>Moderate to severe depression in 12–18 year olds</h5><div id="ch2.s1.1.10.2.3.1"><h5>Depression symptoms at post-treatment, moderate to severe depression in 12 to 18 years old</h5><p>Very low quality evidence from 1 network meta-analysis with 22 RCTs containing 1,886 participants found that the following psychological interventions were effective reducing depression symptoms compared to waiting list/no treatment:
|
|
<ul id="ch2.l175"><li id="ch2.lt545" class="half_rhythm"><div>Individual CBT</div></li><li id="ch2.lt546" class="half_rhythm"><div>IPT-A</div></li><li id="ch2.lt547" class="half_rhythm"><div>Family therapy</div></li><li id="ch2.lt548" class="half_rhythm"><div>Group CBT</div></li></ul></p><p>No interventions were better than others in this group.</p><p>The evidence could not differentiate depression symptoms between the remaining comparators.</p></div><div id="ch2.s1.1.10.2.3.2"><h5>Depression symptoms at ≤6 months, moderate to severe depression in 12 to 18 years old</h5><p>Low quality evidence from 1 network meta-analysis with 5 RCTs containing 703 participants could not differentiate depression symptoms between:
|
|
<ul id="ch2.l176"><li id="ch2.lt549" class="half_rhythm"><div>Individual CBT, psychodynamic psychotherapy, psychosocial intervention, relaxation, family therapy, IPT-A and usual care</div></li></ul></p></div><div id="ch2.s1.1.10.2.3.3"><h5>Depression symptoms at >6 to ≤18 months, moderate to severe depression in 12 to 18 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 4 RCTs containing 706 participants could not differentiate depression symptoms between:
|
|
<ul id="ch2.l177"><li id="ch2.lt550" class="half_rhythm"><div>Individual CBT, psychodynamic psychotherapy, psychosocial intervention, group CBT, group CBT + parent sessions and usual care</div></li></ul></p></div><div id="ch2.s1.1.10.2.3.4"><h5>Functional status at post-treatment, moderate to severe depression in 12 to 18 years old</h5><p>Low quality evidence from 1 network meta-analysis with 9 RCTs containing 926 participants found that the following psychological interventions were effective at increasing functional status compared to waiting list or no treatment:
|
|
<ul id="ch2.l178"><li id="ch2.lt551" class="half_rhythm"><div>Individual CBT</div></li><li id="ch2.lt552" class="half_rhythm"><div>Family therapy</div></li><li id="ch2.lt553" class="half_rhythm"><div>Group CBT + parent sessions</div></li><li id="ch2.lt554" class="half_rhythm"><div>IPT-A</div></li></ul></p><p>The following psychological interventions were effective at increasing functional status compared to usual care:
|
|
<ul id="ch2.l179"><li id="ch2.lt555" class="half_rhythm"><div>Individual CBT</div></li><li id="ch2.lt556" class="half_rhythm"><div>Family therapy</div></li><li id="ch2.lt557" class="half_rhythm"><div>IPT-A</div></li></ul></p><p>The evidence could not differentiate functional status between the remaining comparators.</p></div><div id="ch2.s1.1.10.2.3.5"><h5>Functional status at >6 months to ≤18 months, moderate to severe depression in 12 to 18 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 2 RCTs containing 285 participants could not differentiate functional status between:
|
|
<ul id="ch2.l180"><li id="ch2.lt558" class="half_rhythm"><div>Individual CBT, group CBT and usual care</div></li></ul></p></div><div id="ch2.s1.1.10.2.3.6"><h5>Functional status at ≤6 months, moderate to severe depression in 12 to 18 years old</h5><p>Low quality evidence from 1 network meta-analysis with 2 RCTs containing 260 participants could not differentiate functional status between:
|
|
<ul id="ch2.l181"><li id="ch2.lt559" class="half_rhythm"><div>Individual CBT, relaxation and usual care</div></li></ul></p></div><div id="ch2.s1.1.10.2.3.7"><h5>Remission at post-treatment, moderate to severe depression in 12 to 18 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 8 RCTs containing 875 participants found that the following psychological interventions were effective at increasing remission compared to attention control
|
|
<ul id="ch2.l182"><li id="ch2.lt560" class="half_rhythm"><div>Individual CBT</div></li><li id="ch2.lt561" class="half_rhythm"><div>Family therapy</div></li><li id="ch2.lt562" class="half_rhythm"><div>NDST</div></li><li id="ch2.lt563" class="half_rhythm"><div>Psychodynamic psychotherapy</div></li><li id="ch2.lt564" class="half_rhythm"><div>Psychosocial intervention</div></li><li id="ch2.lt565" class="half_rhythm"><div>Computer CBT</div></li></ul></p><p>The following psychological interventions were effective at increasing remission
|
|
<ul id="ch2.l183"><li id="ch2.lt566" class="half_rhythm"><div>Individual CBT compared to family therapy, NDST, relaxation</div></li><li id="ch2.lt567" class="half_rhythm"><div>Psychodynamic psychotherapy compared to family therapy and relaxation</div></li><li id="ch2.lt568" class="half_rhythm"><div>Psychosocial intervention compared to family therapy and relaxation</div></li><li id="ch2.lt569" class="half_rhythm"><div>Usual care compared to family therapy, relaxation</div></li></ul></p><p>The evidence could not differentiate remission between the remaining comparators.</p></div><div id="ch2.s1.1.10.2.3.8"><h5>Quality of life at post-treatment, moderate to severe depression in 12 to 18 years old</h5><p>Low quality evidence from 1 network meta-analysis with 3 RCTs containing 632 participants found that the following psychological interventions were effective at improving quality of life compared to usual care
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|
<ul id="ch2.l184"><li id="ch2.lt570" class="half_rhythm"><div>Individual CBT</div></li><li id="ch2.lt571" class="half_rhythm"><div>Pill placebo</div></li></ul></p><p>The evidence could not differentiate quality of life between:
|
|
<ul id="ch2.l185"><li id="ch2.lt572" class="half_rhythm"><div>Individual CBT and pill placebo</div></li><li id="ch2.lt573" class="half_rhythm"><div>Psychodynamic psychotherapy compared to pill placebo, individual CBT and usual care</div></li><li id="ch2.lt574" class="half_rhythm"><div>Psychosocial intervention compared to pill placebo, individual CBT, psychodynamic psychotherapy, and usual care</div></li></ul></p></div><div id="ch2.s1.1.10.2.3.9"><h5>Quality of life at ≤6 months, moderate to severe depression in 12 to 18 years old</h5><p>Low quality evidence from 1 network meta-analysis with 2 RCTs containing 469 participants found that the following psychological interventions were effective at improving quality of life compared to usual care:
|
|
<ul id="ch2.l186"><li id="ch2.lt575" class="half_rhythm"><div>Individual CBT</div></li></ul></p><p>The evidence could not differentiate quality of life between:
|
|
<ul id="ch2.l187"><li id="ch2.lt576" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy and psychosocial intervention</div></li><li id="ch2.lt577" class="half_rhythm"><div>Psychodynamic psychotherapy compared to individual CBT, psychosocial intervention, and usual care</div></li></ul></p></div><div id="ch2.s1.1.10.2.3.10"><h5>Quality of life at >6 to ≤18 months, moderate to severe depression in 12 to 18 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 2 RCTs containing 487 participants could not differentiate quality of life between:
|
|
<ul id="ch2.l188"><li id="ch2.lt578" class="half_rhythm"><div>Individual CBT compared to psychodynamic psychotherapy, psychosocial intervention and usual care</div></li><li id="ch2.lt579" class="half_rhythm"><div>Psychodynamic psychotherapy compared to psychosocial intervention and usual care</div></li><li id="ch2.lt580" class="half_rhythm"><div>Psychosocial intervention compared to usual care</div></li></ul></p></div><div id="ch2.s1.1.10.2.3.11"><h5>Suicide ideation (dichotomous) at post-treatment, moderate to severe depression in 12 to 18 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 3 RCTs containing 534 participants found that the following psychological interventions were effective at reducing suicide ideation compared to usual care:
|
|
<ul id="ch2.l189"><li id="ch2.lt581" class="half_rhythm"><div>Individual CBT</div></li></ul></p><p>The evidence could not differentiate suicide ideation between:
|
|
<ul id="ch2.l190"><li id="ch2.lt582" class="half_rhythm"><div>Individual CBT compared to family therapy, NDST, and pill placebo</div></li><li id="ch2.lt583" class="half_rhythm"><div>Family therapy compared to NDST, usual care, and pill placebo</div></li><li id="ch2.lt584" class="half_rhythm"><div>NDST compared to usual care and pill placebo</div></li></ul></p></div><div id="ch2.s1.1.10.2.3.12"><h5>Discontinuation for any reason at end point, moderate to severe depression in 12 to 18 years old</h5><p>Moderate quality evidence from 1 network meta-analysis with 18 RCTs containing 1,886 participants found that the following psychological interventions were effective at reducing discontinuation compared to waiting list or no treatment:
|
|
<ul id="ch2.l191"><li id="ch2.lt585" class="half_rhythm"><div>Group IPT</div></li><li id="ch2.lt586" class="half_rhythm"><div>Behavioural activation</div></li></ul></p><p>The following psychological interventions were effective at reducing discontinuation compared to usual care:
|
|
<ul id="ch2.l192"><li id="ch2.lt587" class="half_rhythm"><div>Group IPT</div></li><li id="ch2.lt588" class="half_rhythm"><div>Behavioural activation</div></li></ul></p><p>The following psychological interventions were effective at reducing discontinuation compared to monitoring:
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|
<ul id="ch2.l193"><li id="ch2.lt589" class="half_rhythm"><div>Individual CBT</div></li><li id="ch2.lt590" class="half_rhythm"><div>IPT-A</div></li><li id="ch2.lt591" class="half_rhythm"><div>Family therapy</div></li><li id="ch2.lt592" class="half_rhythm"><div>Psychodynamic psychotherapy</div></li><li id="ch2.lt593" class="half_rhythm"><div>Group CBT</div></li><li id="ch2.lt594" class="half_rhythm"><div>Group CBT + parent sessions</div></li><li id="ch2.lt595" class="half_rhythm"><div>Group IPT</div></li><li id="ch2.lt596" class="half_rhythm"><div>Behavioural activation</div></li></ul></p><p>The following psychological interventions were effective at reducing discontinuation:
|
|
<ul id="ch2.l194"><li id="ch2.lt597" class="half_rhythm"><div>Individual CBT compared to psychosocial intervention and online guided self-help</div></li><li id="ch2.lt598" class="half_rhythm"><div>Group IPT compared to IPT-A, psychodynamic psychotherapy, psychosocial intervention, online guided self-help, IPT-A + parent sessions</div></li><li id="ch2.lt599" class="half_rhythm"><div>Behavioural activation compared to individual CBT, IPT-A, psychodynamic psychotherapy, psychosocial intervention, online guided self-help</div></li><li id="ch2.lt600" class="half_rhythm"><div>Group CBT compared to online guided self-help</div></li><li id="ch2.lt601" class="half_rhythm"><div>Group CBT + parent sessions compared to online guided self-help</div></li><li id="ch2.lt602" class="half_rhythm"><div>Pill placebo compared to online guided self-help</div></li></ul></p><p>The evidence could not differentiate discontinuation between the remaining comparators.</p></div></div></div><div id="ch2.s1.1.10.3"><h5>NMA sensitivity analyses and inconsistency checking</h5><p>The results of the sensitivity analyses using an alternative approach to converting MD to SMD only detected minor differences in results compared to the original approach used in the NMAs for depression symptoms and functional status post treatment for 12–18 year olds with mild or moderate to severe depression.</p><p>Inconsistency checking identified several networks with potential inconsistency. Sensitivity analyses removing the studies that were potentially inconsistent for depression symptom post treatment and at 6 months for mild depression in 12–18 year olds (see <a href="#ch2.apps">appendix S</a>) led to minor changes in results in most cases, however, in the post treatment NMA, group IPT became disconnected from the network. In the 6 months post treatment network, individual CBT ceased to be effective at reducing depression symptoms compared to waiting list/no treatment amongst other changes.</p></div><div id="ch2.s1.1.10.4"><h5>Published NMA results</h5><p>High quality evidence from 1 published network meta-analysis containing 3,805 participants (children and young people aged 7 to 18 years with depression) found that IPT and CBT were effective at reducing depression symptoms at post-treatment compared to control interventions (including psychological placebo, usual care and waiting list) and compared to play therapy. The evidence was partially applicable because the NMA does not cover all of the outcomes of interest, does not report results by the ages groups of interest to this review, and does not separate interventions by the type of psychotherapy and method of delivery (group and individual forms of a particular type of therapy are combined to form single nodes in the analyses).</p></div><div id="ch2.s1.1.10.5"><h5>Economic evidence statements</h5><ul id="ch2.l195"><li id="ch2.lt603" class="half_rhythm"><div>Evidence from 1 single UK study conducted alongside a RCT (n=470) suggests that cognitive behavioural therapy is likely to be cost-effective in young people compared to brief psychological intervention and short-term psychoanalytic psychotherapy, although there were no significant differences in costs or effects. The evidence is directly applicable to the UK but has potentially serious limitations.</div></li><li id="ch2.lt604" class="half_rhythm"><div>Evidence from 1 single UK study conducted alongside a RCT (n=208) suggests that cognitive behavioural therapy in combination with selective serotonin reuptake inhibitors is unlikely to be cost-effective in young people compared to selective serotonin reuptake inhibitors alone. The evidence is partially applicable to the research question but has potentially serious limitations.</div></li><li id="ch2.lt605" class="half_rhythm"><div>Evidence from 1 single US study conducted alongside an RCT (n=212) suggests that cognitive behavioural therapy combined with treatment as usual is likely to be cost-effective in young people declining selective serotonin reuptake inhibitors compared to treatment as usual. The evidence is partially applicable to the UK and but potentially serious limitations.</div></li><li id="ch2.lt606" class="half_rhythm"><div>Evidence from 1 single US study conducted alongside a RCT (n=327) suggests that cognitive behavioural therapy in combination with fluoxetine is likely to be cost-effective in young people compared to cognitive behavioural therapy or fluoxetine on its own. The evidence is partially applicable to the UK but has potentially serious limitations.</div></li></ul></div></div><div id="ch2.s1.1.11"><h4>The committee’s discussion of the evidence</h4><div id="ch2.s1.1.11.1"><h5>Interpreting the evidence</h5><div id="ch2.s1.1.11.1.1"><h5>The outcomes that matter most</h5><p>The committee agreed that the key outcomes for children and young people with depression were depression symptoms, functional status, remission and quality of life and they made these the primary outcomes for this review to reflect their importance. Depression symptoms and remission were chosen because they could be used to assess whether the interventions were having the desired effect of treating the depressive symptoms experienced by the child or young person. Remission was considered to be harder to achieve than a reduction in depression symptoms measured by a depression scale. Following on from these changes, the interventions would also ideally lead to an improvement in functional status and quality of life, enabling the child or young person being treated for depression to return to school, join in with family life again and resume social activities. The committee also agreed that self-report scales would give the opportunity to children and young people to report their own experience.</p><p>The committee agreed that suicide ideation, suicide-related adverse events and self-harm were also very important outcomes as they could be indications that an intervention was not working or might be harmful. They noted that suicide (ideation or attempts) and self-harm represent signs of distress and were very real risks for children and young people with depression if they are untreated. However, these outcomes were not prioritised because the committee expected that there would be a shortage of evidence, making it harder to use them for decision making than the primary outcomes listed above.</p><p>The committee were interested in examining the data on discontinuation, but acknowledged that this was a complex outcome to interpret and as a result, they did not prioritise it. The committee noted that discontinuation could be caused by many different factors and could include cases where the intervention did not work for the particular child or young person; interventions working sooner than expected leading to drop outs as no more sessions are required; or issues concerning access such as timing of sessions and transport or equality issues (see the section below on ‘other factors the committee took into account’ for a full discussion of equality issues).</p></div><div id="ch2.s1.1.11.1.2"><h5>The quality of the evidence</h5><div id="ch2.s1.1.11.1.2.1"><h5>Deciding on the division of the trials based on the severity of depression of the participants and the age of the child or young person</h5><p>The committee agreed that it was appropriate to try to make separate recommendations based on the severity of the depression and the age of the child or young person because it was expected that younger children were likely to respond differently to treatments compared to young people and the treatments that were most effective might be different for children and young people with mild depression compared to those with moderate to severe depression. As a result, they agreed to divide the analyses into 2 age groups and depression severity levels: 5–11 year olds or 12–18 year olds; mild depression or moderate to severe depression.</p><p>The committee agreed that it was necessary to separate the children and young people into different groups because children differ greatly in their level of development and maturity compared to teenagers. They agreed to retain the categories used in the 2015 and divided the studies into those recruiting 5–11 or 12–18 year olds. However, they noted that within a category 5 year olds (or 12 year olds) would also be very different in their level of development and maturity compared to 11 year olds (or 18 year olds) and that this would likely affect the choice of treatment and its effectiveness.</p><p>These age categories were used in the 2015 update of this review question and the studies that were included previously were kept in the same categories as before for this analysis. In the majority of cases, studies recruited children or young people and it was obvious which category the study fell into as the study age range fell within the 5–11 or 12–18 range. However, in other cases, the age range spanned 2 categories and the decision was based on a combination of the mean age of the participants, if supplied, and the range itself. For example, in <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a> participants were 9–15 years old and had a mean age of 11.71 years. This study was classified under the 5–11 heading here as it was included in this category in the 2015 update, but it could have been included in the 12–18 category instead or as well as the 5–11 category.</p><p>In an ideal situation, the included studies would have recruited children or young people with either mild or moderate to severe depression using recognised instruments. This would have allowed the included studies to be divided up by severity. However, this was not possible as the trials did not recruit participants in this manner. The committee considered dividing the studies based on the mean population characteristics of each study, but decided against this approach because it was unclear which cut off point should be used to distinguish between populations of children and young people with mild or moderate to severe depression for each depression scale reported in the baseline study characteristics table. They were also concerned about using a depression scale in isolation to determine severity as this does not reflect clinical practice, which also includes additional sources of information in the decision making process. As a result, the committee agreed to divide the studies into those with participants with mild or moderate to severe depression based on the study inclusion criteria. Studies that recruited children and young people with a diagnosis of depression were classified as having participants with moderate to severe depression and those using depression symptoms as inclusion criteria were classified under mild depression. However, this classification was not without issue as some of the studies that included children and young people based on depression symptoms excluded those with a diagnosis of depression, whilst others did not and so may have included some participants with more severe depression.</p><p>Some of the studies looking at psychological interventions for depression were aimed at the prevention of depression in high risk groups. These studies were excluded from this review if the participants did not meet the requirement of having depression symptoms at baseline. However, under our classification, studies such as <a class="bibr" href="#ch2.appo.ref19" rid="ch2.appo.ref19">Dobson 2010</a> are grouped with other studies of mild depression as the participants had depression symptoms at baseline. In this case, we interpreted the study as being aimed at preventing the development of more severe depression in young people who already had mild depression.</p></div><div id="ch2.s1.1.11.1.2.2"><h5>Grouping of controls and issues surrounding the use of multiple types of control</h5><p>The studies used a number of controls, which included active interventions such as attention control and usual care, whilst others used no treatment or waiting list as controls. The committee agreed that waiting list or no treatment were sufficiently similar that they could be merged to act as a single node in the NMAs and that these were the most appropriate controls as they reflected real clinical practice most closely. In comparison, in some trials attention control was very intensive and could almost count as an active intervention in its own right. The use of pill placebo as a control was also problematic as there was a risk of a placebo effect. This control was used by a small number of trials that also included a drug intervention arm, but for the purposes of this analysis the drug arm data was not included. The definitions of the controls used in individual trials was varied and they were reclassified based on descriptions provided by the committee to ensure that each control node in the NMA consisted of similar control interventions.</p><p>The committee noted that although the recommended psychological therapies were more effective than waiting list/no treatment in many of the outcomes and time points, this was not the case when compared to attention control or usual care. Instead, many of the active treatments were worse than, or not detectably different from, usual care or an attention control. In the case of the attention control this might be attributed to a large amount of interaction between the researcher and the child or young person with depression acting as an intervention in itself in some trials, reducing the relative effect of the psychological intervention. In contrast, in other trials, an attention control may have involved more minimal contact. The variable nature of usual care, which could include psychological or other therapies or antidepressant treatment, may have had a similar effect to the attention control.</p></div><div id="ch2.s1.1.11.1.2.3"><h5>Modified GRADE methodology and overall quality of the evidence</h5><p>This update used a modification of the GRADE process to assess the quality of the evidence underlying the results for each outcome. Rather than including imprecision in the GRADE tables, the impact of imprecision on the certainty of the effect estimates was discussed with the committee during the presentation of results of the pairwise meta-analysis and NMA. However, this approach meant that the quality of the evidence as presented to the committee and listed in the evidence statements for both the pairwise meta-analyses and NMAs was likely to be graded higher than would otherwise have been the case for some outcomes. (Please refer to the benefits and harms section below for a discussion of the approach taken by the committee to examine imprecision in the results.)</p><p>Overall, the quality of the pairwise evidence varied from high to very low, with the main reason for downgrading being due to risk of bias of the included studies due to a lack of allocation concealment, lack of blinding, and high attrition without information about how missing data was handled.</p><p>The quality of the evidence was moderate for the majority of NMAs. The main reasons for downgrading were due to risk of bias of the included studies for the reasons mentioned above and inconsistency between the results of the pairwise and NMA results. Networks that contained fewer studies were typically graded as being of higher quality than the larger NMAs. These larger networks included outcomes, such as depression symptoms for 12–18 year olds for both severity levels, that were of particular importance and played larger roles in the committee’s decision making process. The analyses with smaller networks, such as for depression symptoms post treatment for 5–11 year olds year olds with moderate to severe depression (<a class="figpopup" href="/books/NBK557360/figure/ch2.appg.fig16/?report=objectonly" target="object" rid-figpopup="figch2appgfig16" rid-ob="figobch2appgfig16">Figure 73</a>), were less likely to show substantial differences between the pairwise and NMA results (and therefore be downgraded for inconsistency) than networks with large numbers of interventions from multiple trials (for example, depression symptoms for 12–18 year olds with mild depression post treatment, <a class="figpopup" href="/books/NBK557360/figure/ch2.appg.fig1/?report=objectonly" target="object" rid-figpopup="figch2appgfig1" rid-ob="figobch2appgfig1">Figure 58</a>). This was not unexpected as the larger, more complex networks contained many more comparisons between the pairwise and NMA results and so there were more chances for individual comparisons to show differences between the pairwise and NMA results and a single discrepancy resulted in the whole network being downgraded. While smaller networks were often graded as higher quality largely as a result of containing fewer studies.</p></div><div id="ch2.s1.1.11.1.2.4"><h5>Interpreting whether the results of the analyses were clinically meaningful</h5><p>To help the committee with their examination of the clinical importance of the effects of the interventions across outcomes, it was necessary to convert continuous outcomes reported on multiple scales to a single scale per outcome to allow the data to be combined. Depression symptoms, functional status, and quality of life were all measured as continuous outcomes using a variety of scales (see <a href="#ch2.appp">appendix P</a> for information about the key scales reported by the included studies). The committee agreed to allow prioritisation of certain scales for data extraction for each outcome based on the most frequently used scales in the included studies, a hierarchy of depression symptom severity measurement scales reported by a Cochrane review of newer generation antidepressants for depressive disorders in children and adolescents (<a class="bibr" href="#ch2.appo.ref269" rid="ch2.appo.ref269">Hetrick 2012</a>) and their own experience (see <a href="#ch2.appq">appendix Q</a> for the ranking of these scales). The pooled results of the meta-analyses for these outcomes are reported in the forest plots and GRADE tables as standardised mean differences (SMDs), or mean differences (MD) where the studies for that particular pairwise comparison used a single common scale.</p><p>However, although SMDs have the benefit of allowing multiple scales per outcome to be combined, it is hard to relate changes in SMDs to clinically meaningful differences that would matter to children and young people with depression. As a result, the committee agreed that it was helpful to back convert the SMDs onto a common scale for each outcome to aid interpretation of the results of the analyses. The committee chose a single highly ranked scale for each outcome based on their experience of using the scales. The standardised mean difference results were then back converted to these scales. In the case of depression symptoms the committee agreed to use the Child Depression Inventory (CDI), for functional status they chose the Children’s global assessment scale (CGAS) and for quality of life they used Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA).</p><p>The committee discussed these scales in detail and reached an agreement on the changes that they thought would be clinically meaningful for each outcome and scale based on their clinical expertise and published literature. For the continuous outcomes these were:
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<ul id="ch2.l196"><li id="ch2.lt607" class="half_rhythm"><div>Depression symptoms: a difference of 8 points on the CDI</div></li><li id="ch2.lt608" class="half_rhythm"><div>Functional status: a difference of 5–10 points on the CGAS</div></li><li id="ch2.lt609" class="half_rhythm"><div>Quality of life: a difference of 5–10 points on the HoNOSCA</div></li></ul></p><p>The committee chose to set a range for the minimal clinically important differences (MIDs) for functional status and quality of life because they thought that the published values were rather high at 10 points on each scale. Since HoNOSCA is measured from 0–52 or 0–60 and CGAS is measured from 1–90 or 1–100, a change of 10 points would be quite large. Details of all identified MIDs are included in <a class="figpopup" href="/books/NBK557360/table/ch2.appb.tab1/?report=objectonly" target="object" rid-figpopup="figch2appbtab1" rid-ob="figobch2appbtab1">Table 9</a>.</p><p>Looking at the continuous outcomes overall, the committee noted that some NMAs had much wider credible intervals (CrIs) than others, which led to increased uncertainty surrounding the results for these outcomes. These NMAs typically consisted of large numbers of interventions, with very few trials per intervention. For example, for depression symptoms post-treatment (at the end of treatment), for moderate to severe depression in 12–18 year olds the CrIs for some comparisons were up to 30 points wide. However, for 5–11 year olds, the CrIs were around 10 points wide on the CDI scale for the same outcome. In other cases, such as quality of life post-treatment in the 12–18 year old age group, the CrIs were much tighter but the network of trials was much smaller.</p><p>For the dichotomous outcomes the committee found it easier to interpret the results of the pairwise analysis using the absolute risk per 100 people rather than by looking at the relative risk as presented by the risk ratio (RR) for the pairwise evidence. They decided that for remission and self-harm a difference of 10 people out of 100 people would likely reflect meaningful differences between interventions. In contrast for suicide ideation and suicide-related adverse events, a smaller difference was important because of the potential severity of these outcomes. For discontinuation they agreed that a difference of 20 people out of 100 people might reflect meaningful differences between interventions. They chose this because they noted that discontinuation from psychological therapy was not the same as for pharmaceutical interventions and there were many possible reasons for discontinuation of therapy that were unrelated to the actual interventions themselves. For example, discontinuation may have been more related to the ages of the participants, their environment and/or the therapy having worked (see ‘<a href="#ch2.s1.1.11.1.1">the outcomes that matter most</a>’ above and ‘<a href="#ch2.s1.1.11.3">other factors the committee took into account</a>’ for more discussion of issues surrounding attendance at therapy sessions). However, the results of the NMAs for dichotomous outcomes were presented in the form of risk ratios and not converted to absolute risks because very few studies reported data for these outcomes and, apart from remission, they were not prioritised for decision making. In the case of remission, there was data for 12–18 year olds with moderate to severe depression in particular, but the majority of CrIs spanned the line of no effect.</p></div><div id="ch2.s1.1.11.1.2.5"><h5>Gaps in the evidence base and issues concerning the reporting of outcomes</h5><p>The committee noted that the majority of the included studies reported data on depression symptoms, but fewer reported functional status and remission. Very few studies reported the impact of the therapies on quality of life. There was limited evidence for the rest of outcomes (suicide-related adverse events, suicide ideation and self-harm) as the majority of RCTs did not report data on these outcomes. The majority of studies included data on discontinuation, but this was hard to interpret as there were multiple reasons that a child or young person with depression could have for discontinuing an intervention, including remission. In addition, the committee identified a number of groups of people whose characteristics could affect their attendance at sessions (see ‘<a href="#ch2.s1.1.11.1.1">the outcomes that matter most</a>’ above and ‘<a href="#ch2.s1.1.11.3">other factors the committee took into account</a>’ for more discussion of these issues). The committee noted that for many of the included studies, the participants on the waiting list were offered the intervention once the trial ended.</p><p>The definition of remission varied across studies. However, these differences were not a barrier for pairwise or network meta-analysis because remission was measured in the same way between arms within single RCTs and the results were analysed as relative effects within trials.</p><p>The committee noted that there was a shortage of trials that recruited younger children aged 5 to 11 years with mild depression and the only active intervention under investigation was group CBT. There was also limited evidence for the same age group with moderate to severe depression. Here the interventions tested were restricted to individual CBT, group CBT, NDST, psychodynamic psychotherapy, family psychoeducation with CBT, family therapy and family based IPT. For both levels of depression severity the study sample sizes were small and there were typically only 1 or 2 trials per therapy.</p><p>There was more evidence for young people aged 12–18 years for both mild and moderate to severe depression, but again sample sizes were small for most included RCTs and some interventions were only examined by 1 or 2 trials. In contrast, individual CBT was included as an intervention in a large number of trials (more than 15 trials across the different depression severity levels for this age group) and group CBT was reported in more than 10 trials.</p><p>The committee also noted that, while all included studies reported data at the end of treatment (post-treatment) there was a shortage of evidence for the effects of interventions at later time points in many cases. They considered shorter term follow up to be up to and including 6 months post-treatment and longer follow up to cover a year to 18 months. The data was analysed for these follow up times for both the pairwise and network meta-analyses, where it was available. Longer time points were not chosen because the committee thought the data would be unreliable, given its paucity and their experience that children and young people between the ages of 5–18 years change dramatically within relatively short periods of time compared to adults.</p><p>Based on the shortage of evidence for effectiveness over time, the committee included a requirement for evidence of effectiveness post-treatment and at later time points in all of the research recommendations they made to help investigate whether the effects of the interventions are maintained over time (see below for the details of these research recommendations).</p><p>The review included studies that recruited children and young people with depression and comorbidities if the focus of the intervention was treatment for depression only, but these studies were excluded if the treatment was for depression <b>and</b> the comorbidty (for example for anxiety <b>and</b> depression). However, these studies were not included in the NMA and kept as separate subgroups in the pairwise analysis in case the presence of the comorbidity altered the effect of the intervention. The committee noted that there were very few studies that recruited people with comorbidities and depression specifically to treat depression, This review identified 3 such studies (<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>, <a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy 2007</a> and <a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy 2014</a>). <a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a> recruited young people aged 12–17 years with a high risk of diabetes, while the other papers recruited 9–17 year olds with inflammatory bowel disease. The committee also noted that the studies that did not deliberately recruit children or young people with a comorbidity, did not present subgroup data for comorbidities. However, the specific management of patients with other physical or psychiatric conditions (ie. comorbidities) was not within the scope of this update and the committee would have been unable to make separate recommendations for these groups even if the data had existed.</p><p>There was a shortage of evidence concerning which psychological therapies were most effective for children and young people who had not responded to a previous psychological therapy. The review protocol included a subgroup analysis to look at the effectiveness of these therapies in people with moderate to severe depression who had either no previous depression, a previous incidence of depression or refractory depression. However, this subgroup analysis was not carried out as the included studies did not provide this information.</p></div><div id="ch2.s1.1.11.1.2.6"><h5>Other issues</h5><p>The committee noted that IPT-A includes a variable number of parent sessions as part of the intervention, but the <a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel (2016)</a> study compared IPT-A with reduced parental involvement to IPT-A with additional parental involvement. They therefore agreed that this study should not be included in the NMA as the IPT-A intervention was not comparable to IPT-A as carried out in other studies and could not be grouped under the same intervention node. Since this study did not include a non-IPT arm, this exclusion could not have influenced the IPT-A results in the NMA.</p><p>A large proportion of the group therapy trials included in this analysis were carried out in a school setting but, as these interventions were administered by healthcare professionals and not teachers, the committee agreed that they could be delivered outside the school setting and were therefore suitable for inclusion in the analysis as types of group therapy. The committee noted that these interventions were aimed at treating children and young people with existing symptoms of depression or a diagnosis of depression rather than at preventing the development of depression in the future. Trials that recruited children and young people at risk of depression and/or that aimed to prevent depression developing in a group of children or young people were not included in this review as they did not meet the review protocol, which required people to have existing symptoms or diagnosis of depression.</p></div><div id="ch2.s1.1.11.1.2.7"><h5>NMA sensitivity analyses and NMA model inconsistency checks</h5><p>Sensitivity analyses were carried out to compare the results obtained by different methods of standardising the study results for continuous outcomes (a process made necessary by different studies using different questionnaires to measure the same outcome). Modified models that standardised at the individual study level (see <a href="#ch2.s1.1.3">methods and processes</a> point 22 for details) were run for: depression symptoms and functional status at post-treatment for 12 to 18 year olds with mild depression; and for the same outcomes post-treatment for 12 to 18 year olds with moderate to severe depression. The results of these models were compared to the original results with only minor differences being identified between the two sets. As a result, the committee were confident that changing the method of standardisation in this manner does not alter the results of the analyses substantially and the committee were able to use the original results to make recommendations.</p><p>A second set of analyses were carried out to examine the networks identified as being potentially inconsistent (<a href="#ch2.apps">appendix S</a>). This focused on the networks for depression symptoms post treatment and at 6 months post treatment for 12–18 year olds with mild depression as these models were of particular importance for the committee’s decision making process. Firstly, the parts of the network containing the potentially inconsistent studies were identified. The characteristics of the studies identified as being potentially inconsistent were examined in detail to determine if there were any differences between these studies and the other studies in the loop in question that could explain the inconsistency. If substantial differences were identified this might suggest that the potentially inconsistent studies should be excluded from the NMA or placed in a separate/different node in the network. These checks focused on key factors that the committee had previously mentioned during their discussions that could potentially alter the results substantially, such as study format (e.g. group in a clinic or primary care setting versus group in a school setting), study population, and the details of the interventions and the controls. Secondly, the characteristics of the other RCTs within the loops were examined to determine whether any of them could be causing the inconsistency instead. In both cases, no differences in study characteristics were identified that could account for the inconsistency and therefore there were no reasons to exclude any of the individual studies.</p><p>Thirdly, the NMA models for these outcomes were re-run without the potentially inconsistent studies to investigate the effects these studies have on the NMA results. In the case of depression symptoms post treatment, <a class="bibr" href="#ch2.appo.ref34" rid="ch2.appo.ref34">Jacob (2016)</a>, <a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice (2008)</a>, and <a class="bibr" href="#ch2.appo.ref2" rid="ch2.appo.ref2">Ackerson (1998)</a> were the only studies looking at guided self-help and their removal led to the loss of this treatment from the network. It also broke the connections with the nodes for group NDST, which had not been recommended, and group IPT, which was recommended. However, the effects on the results for the interventions that were retained in the network were minimal, with all of the interventions that were effective compared to waiting list/no treatment remaining so in the sensitivity analysis. These interventions would still be recommended based on the results of the sensitivity analysis. Group IPT was recommended by the committee based on the original NMA data. The pairwise data from 3 RCTs showed that this intervention was more effective at reducing depression symptoms than group NDST, suggesting that any potential inconsistency in the NMA would not affect conclusions about the interventions effectiveness.</p><p>One study, <a class="bibr" href="#ch2.appo.ref30" rid="ch2.appo.ref30">Hayes (2011)</a>, was identified as the potential source of inconsistency and was removed from the network for the sensitivity analysis for depression symptoms at 6 months post treatment. This RCT reported on individual CBT versus usual care and its removal did not result in the loss of any treatments from the network. The sensitivity analysis showed minor differences in results compared to the original NMA for all comparisons. The only meaningful change was for individual CBT, which ceased to be effective at reducing depression symptoms compared to waiting list/no treatment amongst other changes. However, based on the pairwise results from 3 RCTs, the recommendation for individual CBT would still stand because, compared to usual care, individual CBT reduced depression symptoms post treatment and improved functional status at the same time point. In addition, the improvement in functional status was still detected at 6 months post treatment.</p><p>In conclusion, although statistical inconsistency was identified in the depression symptoms NMA models for 12–18 year olds with mild depression post treatment and at 6 months post treatment, the effects on the results of the NMAs were minor in most cases and, taking the pairwise direct evidence into account where differences were found, and the committee agreed that the recommendations did not need to be changed.</p></div></div><div id="ch2.s1.1.11.1.3"><h5>Benefits and harms</h5><div id="ch2.s1.1.11.1.3.1"><h5>Mild and moderate to severe depression-recommendations included in both severity levels</h5><p>The committee agreed that it is important to involve the children and young people with depression and their families or carers (as appropriate) in the decision making process as much as possible to ensure that they understand which therapies are suitable for them and why and, if there is a choice of suitable therapies, to help them make an informed decision based on their preferences. They made a recommendation to reflect this issue and included it in the sections for both mild and moderate to severe depression. They also noted that this discussion should include the evidence base for the therapies and, in particular, that there is limited evidence for effectiveness in 5–11 year olds).</p><p>The committee also agreed that an equivalent recommendation was required to prompt the practitioner to carry out a full assessment of needs, including the clinical and social/personal history and current situation/environment of the child or young person with depression before making a choice of therapy. The committee chose to include social/personal history to stress the importance of taking a broader individual history than that covered by clinical issues alone. They agreed that a child or young person’s social/personal history could be a major factor in the development of depression and should be taken into consideration during the decision making process. This recommendation was also based on a discussion of the difficulties faced by some children and young people in attending therapy sessions, which may be due to transport problems, poverty or family issues amongst many others (see ‘<a href="#ch2.s1.1.11.3">other factors the committee took into account</a>’ for more discussion of these issues).</p><p>The committee noted that the context or setting in which the treatment was to be provided was also an important consideration as, for example, children and young people in young offenders institutions would have different needs to those living in normal society with parents or carers. By tailoring the therapy to the person’s needs and environment the committee hoped to improve attendance and increase the likelihood of the therapy being effective at relieving depression. This recommendation also included consideration of comorbidities, neurodevelopmental disorders, communication abilities (language, sensory impairment) and learning disabilities as part of the full assessment of needs to ensure that the chosen therapy met the needs of the individual and was provided in a manner that they could understand or access. The committee noted that for certain groups of children and young people, such as those with learning difficulties, the therapies may require adaptation prior to use. They included a reference to the <u>NICE guideline on</u>
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<a href="https://www.nice.org.uk/guidance/ng54/chapter/Recommendations#psychological-interventions" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">mental health problems in people with learning disabilities</a> which has relevant sections on this issue and recommends psychological therapies that are particularly suitable for this group. The committee also noted that an existing recommendation in the section on treatment and considerations in all settings referred to comorbid diagnoses and the need for these to be assessed and manged in parallel with the treatment for depression.</p></div><div id="ch2.s1.1.11.1.3.2"><h5>Mild depression</h5><p>The committee noted that there was a shortage of trials that recruited children aged 5–11 years with mild depression and the 2 trials that did so both looked at group CBT compared to waiting list/no treatment. Group CBT was more effective at reducing depression symptoms post treatment than waiting list/no treatment and the point estimate of effect exceded the threashold set by the committee as being clinically meaningful (−8.23 [−13.78, −2.77]), but this effect was not maintained at later time points and there was no data available for other outcomes. As a result, the committee decided to make a recommendation for this age group to follow the treatments that were effective in 12–18 year olds.</p><p>The committee noted the difficulty of generalising evidence across the age groups as levels of development and maturity can vary greatly both between and within the 5–11 and 12–18 year groups and even between children or young people of the same age. To highlight this issue and ensure the treatment selected was suitable for the individual, the committee included maturity and developmental level in the factors that the healthcare professional should take into account when discussing treatment options with the child or young person and their family (or carer). In addition, the committee agreed that interventions that were effective for 12–18 year olds would not necessarily be effective for younger children, but in the absence of robust evidence for younger children and the continued need for treatment, they agreed that it was important to provide some guidance and the earlier recommendations were designed to give healthcare professional the scope to match treatment to the individual as best as possible. The committee agreed that developmental adapatation of the therapies may be required for 5–11 year olds and included this point in the recommendation as well. In addition, due to the shortage of evidence for effective treatments for 5–11 year olds with mild depression, the committee wrote a research recommendation for this age group. (They included 5–11 year olds with moderate to severe depression in this research recommendation because there is also a shortage of evidence for this group. See the section on moderate to severe depression below for discussion of the limited evidence for this group.)</p><p>Based on the NMAs for 12–18 year olds, the committee noted that group CBT was effective at reducing depression symptoms post-treatment and at 6 months follow up, and reduced suicide ideation compared to a control. These results were based on the data from 10 RCTs that included group CBT as an intervention, while the NMA networks contained up to 25 RCTs in total across interventions. Computer CBT was also better than control for reducing depression symptoms post-treatment (at the end of treatment), and at up to 6 months and up to 18 months later. This intervention was reported in 6 trials. Individual CBT (3 RCTs) was more effective than waiting list/no treatment at reducing depression symptoms at 6 months post-treatment, but not at the end of treatment, and it increased remission post-treatment. In pairwise data from <a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy 2007</a>, which was not included in the NMA because the participants had comorbid irritable bowl disease, individual CBT was also better than usual care at increasing functional status post treatment and at 6 months. Group IPT (3 RCTs) was effective at improving depression symptoms post-treatment and later follow up times (up to 6 months and up to 18 months later) compared to waiting list/no treatment.</p><p>Group NDST (4 RCTs) was more effective than waiting list/no treatment at reducing depression symptoms at 6 months and up to 18 months post-treatment, but not at the end of treatment. In pairwise data (that was not included in an NMA because there were insufficient connected studies to form a network) group NDST could not be differentiated from group IPT for effects on functional status post treatment and at later time points. From the NMAs, group IPT was more effective then group NDST at reducing depression symptoms post treatment, but could not be differentiated from group NDST at 6 months. In addition, group NDST could not be differentiated from group CBT or digital CBT post treatment, or at 6 months follow up for group CBT. Family therapy (1 RCT) also showed a reduction in depression symptoms post-treatment and at 6 months follow up and reduced suicide ideation compared to waiting list/no treatment or usual care. Finally, computer CBT, group CBT, group IPT, individual CBT and family therapy had high probabilities of being more effective at reducing depression symptoms than waiting list/no treatment (<a class="figpopup" href="/books/NBK557360/table/ch2.appg.tab23/?report=objectonly" target="object" rid-figpopup="figch2appgtab23" rid-ob="figobch2appgtab23">Table 34</a>).</p><p>The committee discussed the uncertainty surrounding the effects of the aforementioned interventions for all of the outcomes. They examined the point estimates and the width of the credible intervals (CrIs) and noted that, compared to control, for depression symptoms post-treatment, family therapy, computer CBT and group IPT all had point estimates of over 8 points improvement (−8) on the CDI scale, which was the level the committee thought was likely to be clinically meaningful. Group CBT was just under this level with a point estimate of −6.79, however the upper CrI (−9.92) was greater than −8. The CrI were wide for most of the recommended interventions (e.g. family therapy −18.90, −1.45), and in all cases the CrIs spanned the MID resulting in some uncertainty about the magnitude of effect. The committee also noted that the size of the effect decreased over time with the point estimates of some of the interventions under consideration dropping to below the MID at 6 months, while family therapy, computer CBT and group IPT, were close to the MID.</p><p>For functional status post-treatment, using the pairwise data individual CBT compared to usual care gave 6.90 points improvement on CGAS, which is greater than the bottom limit of +5 for a clinically meaningful effect. The CrIs were also quite wide at 1.89, 11.91, but the upper CrI was greater than the upper limit of the range set by the committee as an MID for this outcome (+10).</p><p>The committee noted that, most of the evidence was for depression symptoms rather than functional status. Therefore, they agreed to prioritise depression symptoms as the key outcome to make recommendations based on the amount of evidence on this outcome and the magnitude of effcets. The committee also agreed that most of the included studies reported depression symptoms at the end of treatment (post-treatment) and that in their experience, this evidence is likely to be more indicative of the effectiveness of the treatment than later time points as children and young people between the ages of 5–18 years can change dramatically within relatively short periods of time.</p><p>Based on the findings discussed above, the committee made a strong recommendation for digital CBT (also known as online CBT or computer CBT), group CBT, group IPT or group NDST to be offered to 12–18 year olds with mild depression for a limited period of approximately 2–3 months if the young person lacked significant comorbid problems or active suicidal ideas or plans.</p><p>The committee envisaged that digital CBT could be more readily available for children and young people with depression than an individual treatment, which might have long waiting lists. Group therapy might meet the needs of other individuals better. In addition, the average costs estimated for computer CBT and group therapy (CBT, IPT, and NDST) were lower compared to individual CBT and family therapy (see ‘<a href="#ch2.s1.1.11.2">cost-effectiveness and resource use</a>’ below for more discussion of these issues).</p><p>The comittee used the term digital CBT in the recommendation to highlight that computer CBT could also be delivered using different electronic devices, such as phone and tablets, or be accessed via a downloadable programme. The committee noted that the trials of computer CBT involved online access in the majority of cases, but the programmes used varied across studies They were unable to recommend a specific programme as this review did not examine the relative effectiveness of individual computer CBT programmes, but rather looked at their effectiveness as a class compared to other interventions.</p><p>The committee recognised that for the digital CBT recommendation to be implemented in practice, there would need to be additional research to determine which digital CBT package would be most appropriate for a UK population. They envisaged that this would follow a similar process at the local or national level as that used to determine which digital CBT packages are available on the NHS for adults with depression. The committee also noted that digital CBT could be offered as supported digital CBT, involving contact with a healthcare professional and in other cases there may be no additional support. The committee were unable to recommend one form of digital CBT over another as the majority of included studies appeared to be for unsupported digital CBT, but it was not always clear from the way the trial was reported which form was used in a particular trial. In order to determine which form of digital CBT is most effective for a UK population, the committee wrote a research recommedation on this topic.</p><p>The committee noted that the studies in this review used a variety of different packages such as SPARX, Stressbusters, and Grasp the Opportunity, but only Stressbusters was trialled in the UK. These programmes contained some common components including: psychoeducation, relaxation, analysis of behaviour, behavioural activation, basic communication and interpersonal skills, emotional recognition, dealing with strong emotions, problem solving, cognitive restructuring (identifying thoughts, challenging unhelpful/negative thoughts), mindfulness, and relapse prevention, but it was unclear which components of the programmes were responsible for its effectiveness in practice. As a result, they also included in the recommendation that the research should try to determine which components of the intervention influence effectiveness to enable the selection (or design) of a programme that contains these components.</p><p>The combination of similar levels of effectiveness with differing degrees of likely availability of therapies and costs to the health system led the committee to make tiered recommendations to first offer a choice of digital CBT or group therapies (CBT, IPT or NDST) for children and young people with mild depression. However, the committee acknowledged that these options may not meet the needs of the individual and as a result they offered individual CBT and family therapies as alternatives for these cases. The committee specified attachment based family therapy in the recommendation because the study that provided the evidence for this recommendation used this form of family therapy.</p><p>Individual CBT (4 RCTs) was better at reducing depression symptoms at 6 months post treatment compared to waiting list/no treatment, but not at post treatment. It also improved remission post treatment and functional status post treatment and at 6 months. The point estimate for the improvement in depression symptoms at 6 months was less than the value that the committee thought would be clinically meaningful at −2.29 and the CrIs did not cross the 8 point boundary. The improvements in functional status fell within the range specified by the committee as being clinically meaningful at 6.90 (1.89, 11.91) post treatment and at 6 months (5.90 [1.93,9.87]). However, the results on functional status came from a study that recruited young people with irritable bowel syndrome and depression and although the committee agreed that it was likely that these effects would also be seen in young people without the comorbidity, some uncertainty remained. Taking these points into consideration, along with the higher costs of individual CBT compared to group therapies and digital CBT, the committee agreed that individual CBT should be considered as a second line choice if the other options were unsuitable or failed to meet the young person’s needs.</p><p>Family therapy was included as a second line option because, although the point estimates for effect on depression symptoms post treatment exceeded the MID compared to waiting list/no treatment (−10.11 [−18.90, −1.45]), at 6 months follow up this was just under the MID (−7.76 [−12.39, −3.17]) the results were based on a single RCT with 66 participants. However, family therapy was better at reducing depression symptoms than individual CBT at 6 months post treatment and at reducing suicide ideation compared to usual care and it might be the most suitable type of therapy for a particular young person.</p><p>Although group mindfulness was better than waiting list/no treatment at reducing depression symptoms post treatment and at 6 months in the NMA, this intervention was not recommended because the effect was not sustained longer term and no data was available for effects on other outcomes such as functional status. In addition, the committee noted that the data for this intervention came from a single, small US based study with 33 female participants who were at risk of type 2 diabetes due to being overweight or obese (<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>). The committee therefore agreed that the evidence behind the results for group mindfulness were insufficiently robust to change UK practice. However, the committee agreed that a research recommendation was appropriate to investigate the effectiveness of group mindfulness compared with other psychological therapies with a larger sample size of UK participants to allow differences in effectiveness between interventions to be detected. They also specifed that longer term follow-up should be carried out to determine whether the effects of group mindfulness are short-lived or maintained over time.</p><p>The committee also decided not to making positive recommendations for individual non-directive supportive therapy (NDST) or guided self-help for the following reasons:
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<ul id="ch2.l197"><li id="ch2.lt610" class="half_rhythm"><div>Individual NDST was not more effective at reducing depression symptoms for this severity group than control (waiting list/no treatment, attention control or usual care) post-treatment and was less effective than group or computer CBT, group NDST, group IPT or family therapy at 6 months follow up. There was no data on other outcomes and the evidence came from 1 RCT.</div></li><li id="ch2.lt611" class="half_rhythm"><div>Although guided self-help was more effective than waiting list/no treatment for depression symptoms post-treatment, it was not more effective than the newly recommended group therapies (group CBT, group NDST, group IPT), computer CBT, individual CBT or family therapy. In addition, the effect on depression symptoms compared to waiting list/no treatment was not sustained at 6 months post-treatment, and guided self-help was also less effective than group or computer CBT, group NDST, group IPT, family therapy, usual care or attention control at 6 months follow up.</div></li></ul></p><p>Relaxation, dance therapy and group with computer CBT also had high probabilities of being more effective at reducing depression symptoms than waiting list/no treatment (<a class="figpopup" href="/books/NBK557360/table/ch2.appg.tab23/?report=objectonly" target="object" rid-figpopup="figch2appgtab23" rid-ob="figobch2appgtab23">Table 34</a>). They were not recommended for the following reasons:
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<ul id="ch2.l198"><li id="ch2.lt612" class="half_rhythm"><div>Relaxation was more effective at reducing depression symptoms post-treatment than waiting list/no treatment, but this effect was not sustained at 6 months post-treatment (<a class="figpopup" href="/books/NBK557360/table/ch2.appg.tab3/?report=objectonly" target="object" rid-figpopup="figch2appgtab3" rid-ob="figobch2appgtab3">Table 14</a>) and there was no evidence for the effects of this therapy on functional status, quality of life, or remission (not reported in the 2 included RCTs).</div></li><li id="ch2.lt613" class="half_rhythm"><div>Dance therapy was trailled in 1 RCT with 40 participants and this study only reported effects on depression symptoms post treatment. This result was judged to be low quality due to high risk of bias of the study.</div></li><li id="ch2.lt614" class="half_rhythm"><div>Group with computer CBT was more effective than waiting list/no treatment at reducing depression symptoms post-treatment and at 6 months, but there was no evidence for other outcomes apart from discontinuation and these results were based on evidence from a single study looking at this intervention. In addition, group with computer CBT was not more effective at relieving depression symptoms than group CBT (<a class="figpopup" href="/books/NBK557360/table/ch2.appg.tab2/?report=objectonly" target="object" rid-figpopup="figch2appgtab2" rid-ob="figobch2appgtab2">Table 13</a>), which was recommended, and this intervention likely to be more resource intensive than group CBT alone.</div></li></ul></p><p>The committee stressed that it was important for people to be trained and skilled in the therapies they are delivering and they included a link to the relevant recommendations in the guideline to highlight this point. However, they noted that these therapies could be provided in multiple settings such as primary care, schools, social services, the community and the voluntary sector as well as in tier 2 child and adolescent mental health services (CAMHS). The committee made a recommendation to make people aware of these different settings, but they agreed that the list was not meant to be exhaustive. The committee noted that this guideline does not cover non-healthcare related professionals, such as school teachers, and as a result if an intervention was to be carried out in a school setting it was envisaged that a trained practitioner would be involved. (This would not exclude a person from being both a trained practitioner and school teacher.)</p><p>The committee agreed that it was appropriate to refer children and young people with depression for review by a tier 2 or 3 CAMHS team if they did not respond to the treatment within a specific time frame allowed (2–3 months) and made a recommendation to reflect this point. In addition, they agreed that the recommendations for moderate to severe depression would apply for these people. However, the committee noted that the terminology for tier 2 or 3 CAMHS is under revision currently and may change in the future.</p><p>The committee wrote a research recommendation for a brief psychosocial intervention to be tested in 12–18 year olds with mild or moderate to severe depression. The committee also wrote a second research recommendation to promote investigation of the effectiveness of behavioural activation in children and young people with mild depression. The rationale for these recommendations is detailed at the end of the section on moderate to severe depression below as the recommendations covered both mild and moderate to severe depression and were based on studies that included 12–18 year olds with moderate to severe depression.</p></div><div id="ch2.s1.1.11.1.3.3"><h5>Moderate to severe depression</h5><p>The committee agreed that, due to the severity of their depression, children and young people presenting with moderate to severe depression should be reviewed by a CAMHS team who can provide suitable further assessment and treatment suitable for this severity of depression. They made a recommendation to reflect this.</p><p>The committee agreed that there was a shortage of evidence for many of the interventions in the 5–11 year age group with moderate to severe depression and the evidence of benefit of the therapies compared to control was absent. There was evidence for family based IPT, psychoeducation with CBT, psychodynamic psychotherapy, NDST, group CBT, individual CBT and family therapy. In the pairwise data, none of the interventions that were tested against a control were better than the control for reducing depression symptoms post-treatment. The NMA networks only contained some of these interventions, due to a lack of common interventions to make a larger network, and these did not include a control. From the NMA results, family IPT was more effective at reducing depression symptoms post treatment than psychodynamic psychotherapy (−7.05 [−13.73, −0.39]) and family therapy was more effective than psychodynamic psychotherapy (−5.20 [−8.96, −1.46]), while in the pairwise data psychodynamic psychotherapy was more effective at increasing remission at 6 months than family therapy (1.23 [1.04, 1.45]). These results were based on 3 RCTs with up to 244 people.</p><p>Due to the lack of clear evidence for effectiveness for the psychological therapies in 5–11 years olds, the committee made a recommendation based on their clinical expertise, taking into account the limited evidence for thiss age group and the evidence from the 12–18 year olds with moderate to severe depression. They recommended that family based IPT, family therapy or psychodynamic psychotherapy be considered because they were suitable for younger children and were more effective than other therapies in the NMA. They also included individual CBT in this recommendation because it was the most effective treatment for 12–18 year olds with moderate to severe depression and they agreed that older or more mature children might benefit from this intervention. In all cases, they agreed that development adaptation of the therapies to suit the child and regular monitoring were important. They envisaged that the earlier recommendations on tailoring the choice of intervention to the individual needs of the child and their maturity and developmental level would also help to ensure that the child received a suitable treatment. In addition, the committee included a research recommendation specifically aimed at the 5–11 age group to try to stimulate research in this area. The recommendation also covered children with mild depression because there is a shortage of evidence for the most effective treatments for this group of children as well.</p><p>The committee noted that multiple forms of family therapy exist, including family-focused treatment for childhood depression, attachment based and systemic family therapy, but agreed that they were sufficiently similar that they could be analysed under the grouping of family therapy. The committee specified the types of family therapy in the recommendation based on the forms used by the studies included in the evidence base for 5–11 year olds with moderate to severe depression.</p><p>The committee noted that the terms “psychodynamic psychotherapy” and “psychoanalytic psychotherapy” are sometimes used interchangeably but that more usually, psychoanalytic psychotherapy is regarded as a narrower term than psychodynamic psychotherapy. This update searched for studies of psychodynamic psychotherapy and thus this term was retained throughout, but the committee noted that both the studies found (<a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a>; <a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a> – IMPACT trial) were of the same model of psychoanalytic psychotherapy, which in the IMPACT trial was labelled “Short-term Psychoanalytic Psychotherapy” or STPP. In the recommendations they chose to use the term psychodynamic psychotherapy to encompass this class of intervention.</p><p>The committee examined the results of the NMAs for all of the outcomes for the 12–18 age group with moderate to severe depression in detail. Please note that all of the discussion from this point onwards is based on the analyses of evidence from the 12–18 age group with moderate to severe depression, unless otherwise specified.</p><p>Based on the results of a single NMA containing 22 RCTs, the committee identified a number of possible interventions which were more effective at reducing depression symptoms post-treatment compared to waiting list/no treatment or usual care. These results were based on the data from RCTs that included individual CBT (10 RCTs), family therapy (4 RCTs), IPT-A (4 RCTs), and group CBT (4 RCTs) as an intervention. In addition, these interventions also had the highest probabilities of being effective compared to waiting list/no treatment (<a class="figpopup" href="/books/NBK557360/table/ch2.appg.tab24/?report=objectonly" target="object" rid-figpopup="figch2appgtab24" rid-ob="figobch2appgtab24">Table 35</a>).</p><p>Individual CBT was also more effective than control for the following outcomes: functional status at post-treatment; quality of life at post-treatment and suicide ideation at post-treatment. In addition, individual CBT was more effective at inducing remission post-treatment compared to family therapy, NDST, and relaxation.</p><p>The committee discussed the uncertainty surrounding the effects of individual CBT for all of the outcomes where NMA results were available. For depression symptoms post-treatment, individual CBT had a point estimate of effect of −9.88, which was greater than the clinically meaningful level of −8. Again the CrIs were quite wide, but the lower CrI was very large at −15.66. For functional status compred to waiting list/no treatment, the point estimate was 6.59, which was within the range of 5–10 the committee agreed would be clinically meaningful (CrI 0.26, 12.87); and compared to usual care 4.27 (2.00, 6.55). Based on the magnitude of effects, the number and range of outcomes showing effects and the large number of studies trialling individual CBT, the committee decided to recommend individual CBT as the first line treatment for 12–18 year olds with moderate to severe depression.</p><p>The committee also decided to make a weaker recommendation for family therapy, IPT-A, brief psychosocial intervention (BPI) and psychodynamic psychotherapy as second line treatments should individual CBT not meet the young person’s clinical needs or be unsuitable based on the following rationale.</p><p>Family therapy (4 RCTs) was more effective than control for the following outcomes at post treatment: depression symptoms; functional status and remission. The post treatment results for family therapy compared to to waiting list/no treatment were greater than the MID at −8.95 (−18.38, −0.14) for depression symptoms, and functional status (8.97 [1.41, 16.60]) was well within the clinically meaningful range. Family therapy was also effective compared to usual care for functional status post treatment (6.67 [1.92, 11.47]) and better at inducing remission than attention control (4.76 [1.20, 33.33]). It was not recommended as a first line treatment because although it had similar magnitude of effects for functional status and depression symptoms compared to individual CBT, there was no data on suicide ideation and quality of life and the evidence base for family therapy was much smaller (4 studies versus 10 for individual CBT).</p><p>IPT-A (4 RCTs) was effective at reducing depression symptoms and increasing functional status post-treatment compared to waiting list/no treatment or usual care. The effect post treatment was greater than the MID for depression symptoms (−9.68 [−18.29, −1.12]) and for functional status compared to waiting list/no treatment 9.59 (1.21, 18.00) or usual care (7.30 [1.28, 13.24]). IPT-A was recommeded as a second line intervention because there was no data for remission, suicide ideation or quality of life, or for later time points for functional status and IPT-A was no better or worse than other interventions or controls at 6 months for depression symptoms</p><p>The committee also discussed the evidence for effectiveness of the BPI, which was trialled in the IMPACT study. In this study, BPI was not found to be less effective than psychodynamic psychotherapy or individual CBT across a range of outcomes and time points. In the NMAs, BPI was also effective at increasing remission at post-streatment compared to attention control and compared to family therapy and relaxation, although it was not detectably different to psychodynamic psychotherapy. Based on these results and considering the likely lower cost of BPI compared to psychodynamic psychotherapy (<a class="figpopup" href="/books/NBK557360/table/ch2.appl.tab3/?report=objectonly" target="object" rid-figpopup="figch2appltab3" rid-ob="figobch2appltab3">Table 39</a>), they decided to also recommend that BPI be an option. However, since the evidence for the effectiveness of a brief psychosocial intervention (BPI) or psychodynamic psychotherapy was weaker than for individual CBT, the committee only made a ‘consider’ recommendation for these interventions should individual CBT be otherwise contraindicated or should this intervention prove more appropriate for the individual’s situation and clinical needs.</p><p>The committee discussed the evidence for psychodynamic psychotherapy (also called STPP or short term psychoanalytic psychotherapy in the IMPACT trial). Psychodynamic psychotherapy was effective at increasing remission post-treatment compared to attention control (1 NMA with 8 RCTs) and compared to family therapy and relaxation. However, there was no evidence for functional status and psychodynamic psychotherapy was not more effective than control at relieving depression symptoms or improving quality of life post-treatment. The committee noted that the evidence for psychodynamic psychotherapy in the NMA came from 1 trial (versus a brief psychosocial intervention (BPI) or individual CBT). They also noted that the IMPACT trial was unable to detect a difference in effectiveness between individual CBT and psychodynamic psychotherapy on a range of outcomes across different follow-up periods. However, an additional trial, <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a>, also tested this intervention in 9–15 year olds, but was included in the analysis of the 5–11 age group. This trial showed that psychodynamic psychotherapy could not be differentiated from family therapy for functional status post treatment and at 6 months, while depression symptoms were reduced by family therapy compared to psychodynamic psychotherapy post treatment, but could not be differentiated at 6 months follow up. These findings provide extra support for the inclusion of psychodynamic psychotherapy in the recommendations, but the lack of effect compared to a control for depression symptoms and small number of trials led to committee to make it a 2<sup>nd</sup> line treatment.</p><p>The committee recognised that there were fewer studies of family therapy, IPT-A and psychodynamic psychotherapy, but they agreed that the evidence supported the option of these interventions in clinical practice. However they were also in agreement that further research in this area would be useful to provide evidence about the relative effectiveness of these interventions compared with each other and individual CBT.</p><p>The committee noted that parental involvement is an explicit element in IPT-A, BPI, family therapy and psychodynamic psychotherapy, and sometimes in CBT, in trials included in this analysis. Parent work is carried out in different ways for different psychotherapies and can be very important for work with children and young people with depression.</p><p>The committee decided not to recommend group CBT for the following reasons:
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<ul id="ch2.l199"><li id="ch2.lt615" class="half_rhythm"><div>Group CBT was more effective than waiting list/no treatment at reducing depression symptoms post-treatment, but was not detectably better than usual care or waiting list/no treatment at improving functional status post-treatment. There was no evidence for quality of life or remission outcomes. In addition, the committee had already recommended individual CBT which was also more effective than control for other outcomes such as functional status; quality of life and suicide ideation.</div></li></ul></p><p>The committee recognised that the recommendations for BPI were based on NMA networks incorporating a single RCT testing BPI in young people aged 12–18 years with moderate to severe depression. As a result, they included a research recommendations to explore the clinical effectiveness of this intervention further in comparison with other psychological therapies or control interventions in this age and severity group. In particular, committee noted that >80% of the therapists delivering BPI in the IMPACT trial were psychiatrists and it is unclear whether the results obtained by these staff would be generalisable to current practice in the NHS, given that BPI is designed as a simpler, less intensive psychological intervention that requires less specialist training to deliver. The committee noted that in future trials of BPI the intervention should be carried out by practitioners other than psychiatrists to confirm that the lack of differences seen between BPI and individual CBT or psychodynamic psychotherapy was not due to the relative seniority of the staff conducting the intervention in the IMPACT trial. In addition, they also included a requirement within the research recommendation to investigate the effectiveness of BPI in other settings, including primary care. In addition, the committee expanded this research recommendation to include young people aged 5–11 years old because they noted that this intervention has yet to be tested in this group and could be beneficial for them too.</p><p>The committee also made a research recommendation to investigate the effectiveness of behavioural activation because this therapy may meet the specific needs of some children and young people with mild or moderate to severe depression that are not already covered by the other recommended psychological therapies. Behavioural activation is particularly helpful in treating the symptoms of withdrawal from social activities, inactivity and avoidance which are common symptoms for young people who experience depression. In addition, some children and young people might find it difficult to engage with the concepts of CBT but be more able to respond to behavioural activation because the link between behaviour and mood is an every day experience that they would be used to. Additionally, it could be more suitable for younger children and for children with learning disabilities or neurodevelopmental disorders. Only 1 RCT (<a class="bibr" href="#ch2.appo.ref46" rid="ch2.appo.ref46">McCauley 2016</a>) was identified which compared behavioural activation with usual care in adolescents with a diagnosis of depression at recruitment (moderate to severe depression). The RCT could not detect any differences between behavioural activation and usual care in depression symptoms and functional status at post-treatment. However, the sample size was small (60 participants) and it is possible that a larger trial would be able to detect an effect on these outcomes. The committee included children aged 5–11 years and young people aged 12–18 years with mild or moderate to severe depression in this research recommendation because they agreed that both age groups and severities of depression could potentially benefit from this intervention and this review did not identify any studies using behavioural activation in 5–11 year olds or 12–18 year olds with mild depression or 5–11 year olds with moderate to severe depression.</p><p>In all of the research recommendations, a sufficiently large sample size is essential to allow differences in effectiveness between interventions to be detected. They also specify that longer term follow-up is carried out as many RCTs included in this review only look at the effect of the psychological intervention post–treatment and it is important to determine whether the effects of the interventions are short-lived or maintained over time.</p></div></div></div><div id="ch2.s1.1.11.2"><h5>Cost effectiveness and resource use</h5><p>A systematic review of health economic evidence found four published economic evaluations, which considered the cost-effectiveness of individual CBT, variously with or without selective serotonin reuptake inhibitors (SSRIs) compared to usual care, BPI or STPP (see the Economic evidence section for details). Three of the studies examined the cost-effectiveness of individual CBT, and were found to be partially applicable with potentially serious limitations. The committee agreed that these studies did not provide sufficient evidence to draw firm cost-effectiveness conclusions.</p><p>In addition, the committee discussed the IMPACT study which considered CBT and STPP versus BPI in adolescents with depression. There were no statistically significant differences in costs or effectiveness between the interventions, leading the authors to conclude that BPI might be a valuable lower-intensity addition to the ‘menu’ of psychological treatments. The committee discussed that the evidence for BPI is only partially applicable due to high proportion of psychiatrists delivering BPI within the study, although BPI could potentially be a cost-effective option if it could be delivered as effectively by less specialist CAMHS staff. However, although BPI was not shown to be any worse than the other interventions, no conclusions can be drawn about whether it is non-inferior to the other interventions because the study was not powered to detect non-inferiority.</p><p>The committee decided that de novo health economic modelling was not required to answer the research question. Instead, the committee discussed the opportunity cost of each therapy (health gain lost by choosing an alternative option) by qualitatively considering the evidence on resource use alongside the clinical evidence (for full details see <a href="#ch2.appl">appendix L</a> – Costing Exercise). Resource use data were obtained from the most relevant studies in the clinical review, including information on staff, number and length of sessions, number of participants and average attendance (where available), as well as the committee’s expert opinion. Given data limitations, costs were presented as estimated ranges rather than definitive point estimates of mean costs, with the aim of capturing the potential range of costs associated with the various interventions.</p><p>The committee discussed the units of resource use and associated costs presented to them, with a particular focus on the estimated average costs per person treated and the opportunity costs of missed appointments. The two extremes of costing missed appointments are to: a) assume that there is no opportunity cost associated with a non-attendance (an opportunity cost of 0% of sessions that were missed), or b) assume that the full cost of the entire course of sessions is incurred, regardless of whether or not the person attended (an opportunity cost of 100% of sessions that were missed). The committee agreed that there are many complexities surrounding non-attendance, including that it was difficult to tell whether average attendance figures reported in the studies were related to earlier-than-planned effectiveness, ineffectiveness, unpalatability of specific interventions or a combination of these. There was no strong evidence that participants were more likely to attend the maximum number of sessions planned for one intervention than any other but such evidence as there was did not contradict the committee’s experience that more intensive interventions are likely to have lower overall attendance rates (as a proportion of planned sessions). They agreed the true opportunity cost associated with each intervention was uncertain but likely to lie between the two extremes outlined above. Despite this, it was agreed that it is the ranking of the costs of the interventions that is important, rather than the absolute costs, so any inaccuracies in the cost estimates are unlikely to have affected conclusions as long as a consistent approach was applied to all interventions. As such, the opportunity cost of missed appointments was not included explicitly and the committee did not attempt to be more precise in its quantification of costs than the estimates set out in <a href="#ch2.appl">appendix L</a>, although they noted that the per hour staffing costs were perhaps uniformly a bit high compared to current practice. It was, however, agreed that group and computer based psychological interventions are generally expected to have a lower average cost per patient than individual psychological interventions.</p><p>After qualitative assessment of the evidence, the committee were happy that the cost ranges that were presented represent reasonable estimates. They agreed that interventions with lower cost should be favoured if their effectiveness and suitability are comparable, while acknowledging the limitations of the cost data. Importantly, the consensus was that although practitioners should take costs into account to some extent, cost alone is not a reason to deny an individual the most appropriate intervention for their needs. Areas where cost influenced the decision to recommend certain treatments are outlined in the “benefits and harms” section above along with the other outcomes the committee considered important.</p></div><div id="ch2.s1.1.11.3"><h5>Other factors the committee took into account</h5><p>The committee noted that there were potential differences between the responsiveness of males and females to the psychological interventions, but the included studies did not report any subgroup analyses based on sex. They also noted that the incidence of depression increased greatly in girls as they reach puberty. In order to facilitate examination of this issue the committee included sex under the list of subgroup analyses listed for their research recommendations.</p><p>The committee identified a number of potential equality issues which included those concerning: young offenders, looked after children, ethnic/cultural/language differences, physical access to the sessions, computer access, sensory deficits (for example hearing/sight) socioeconomic status and people with neurodevelopmental disorders.</p><p>Many of these issues were related to difficulties in ensuring the attendance/access of the children and young people with depression to the therapy sessions.</p><ul id="ch2.l200"><li id="ch2.lt616" class="half_rhythm"><div>Children and young people living in rural areas might have problems with travelling to their appointments if public transport is sporadic and unreliable, and their parents/carers are unable to drive them there.</div></li><li id="ch2.lt617" class="half_rhythm"><div>Some children and young people, particularly those from lower socioeconomic backgrounds, might not have access to a computer or suitable device to access the therapy if an online or, computer based therapy is the preferred option. They may also lack internet at home or have insufficient data on mobile phones to access online therapies. Alternatively, they may have access, but not be able to use online systems due to a lack of experience with computers or lack the privacy needed to complete the therapy if they only have access using a school or public library computer. Alternatively, they may have parents who control their computer use and may prevent them from accessing the therapy. (The unsuitability of digital therapy for very young children is not an equality issue, but rather a developmental one, and should be taken into account by the practitioner when matching the therapy to the person.)</div></li><li id="ch2.lt618" class="half_rhythm"><div>Young offenders depend on their carers/prison officers to escort them to appointments and these appointments may not be a priority for the staff at these institutions.</div></li><li id="ch2.lt619" class="half_rhythm"><div>The committee advised that adolescents are less likely to turn up to appointments compared with children aged 5 to 11 years and this is not dependent on the severity of depression. This may be due to a number of factors including transport problems and issues with remembering to go to the appointment if not escorted by parents or carers. In contrast, children aged 5–11 years are likely to be brought to sessions by parents and carers and have better attendance as a result.</div></li><li id="ch2.lt620" class="half_rhythm"><div>Children and young people from lower socioeconomic groups may lack the financial support required to ensure that they attend the sessions. These families may also be less likely to seek help in the first place and/or less able to navigate the healthcare system to ensure that the child or young person receives the help they require.</div></li><li id="ch2.lt621" class="half_rhythm"><div>Children and young people with more chaotic home lives (for example, due to alcohol and drug misuse by family members, neglect or absence) may lack the family support required to ensure that they attend the sessions. These families may also be less likely to seek help in the first place and/or be less willing or able to navigate the healthcare system to ensure that the child or young person receives the help they require.</div></li><li id="ch2.lt622" class="half_rhythm"><div>Children and young people from abusive homes may be prevented from seeking help and/or attending therapy sessions by controlling parents or carers. They may be afraid to leave the home and be unable to protect other family members if there is a violent or abusive member of the household.</div></li><li id="ch2.lt623" class="half_rhythm"><div>Looked after children and young people may lack the support they need to engage with mental health services.</div></li><li id="ch2.lt624" class="half_rhythm"><div>The way that children and young people with depression and their families view mental health problems may be affected by their ethnic, religion and cultural background. Families or carers from some ethnic groups/religious or cultural backgrounds may view mental health issue as shaming or stigmatising and be less likely to seek medical help as a result. Or they may be less able to navigate the healthcare system to ensure that the child or young person receives the help they require. Language difficulties may also hinder access to treatment.</div></li><li id="ch2.lt625" class="half_rhythm"><div>Children and young people with neurodevelopmental disorders might respond differently to various psychological therapies. (This may also be the case for children and young people with learning disabilities, but these issues are covered in <a href="https://www.nice.org.uk/guidance/ng54" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NICE guidance NG54</a> on mental health problems in people with learning disabilities: prevention, assessment and management for recommendations covering psychological interventions for people with learning disabilities to treat depression.)</div></li><li id="ch2.lt626" class="half_rhythm"><div>LGBTQ children and young people may have different requirements to other children and young people with depression.</div></li><li id="ch2.lt627" class="half_rhythm"><div>Children with physical illnesses, such as cancer, may have additional requirements due to their physical illness.</div></li><li id="ch2.lt628" class="half_rhythm"><div>Children and young people with sensory deficits (eg sight/hearing) may find it harder to attend or engage, for example with digital CBT, or with talking therapies.</div></li></ul><p>The committee dealt with these issues in several ways. Firstly, by recommending: that practitioners should discuss the choice of therapies with children and young people and their family members or carers (as appropriate) and explain what the different therapies involve and how these might meet their needs, preferences and values. By promoting the involvement of children and young people with depression and their families or carers (as appropriate), in the shared decision making process cases of non-attendance that occur because the person with depression or their family member/carer does not like/want that particular type of psychological therapy may be reduced. In addition, the family members/carers will have a greater understanding of what is involved in the psychological therapy and may be more able to provide support for the child or young person with depression.</p><p>Secondly, the committee recommended that the choice of interventions is based on a full assessment of needs, including the circumstances of the person and their carer(s), their history and presentation, and the context in which treatment is to be provided. The committee noted that consideration of these factors should help practitioners to identify the needs and circumstances of the person and to choose the best psychological therapy for them. For example, this could involve ensuring that children and young people who do not a suitable device and data or an internet connection are not offered an online therapy and that people in young offenders institutions are not penalised if they miss sessions due to a lack of staff to supervise their transfer to the sessions. In addition, for mild depression, the recommendations include a choice of group, digital or individual therapy allowing the format of the sessions to match the needs and preferences of the child or young person with depression. The committee also included consideration of neurodevelopmental disorders and communication needs (language, sensory impairment) as part of the decision making process. They noted that language and learning difficulties may affect communication, for example in deaf children and young people whose first language is British Sign Language.</p><p>Thirdly, the recommendations for mild depression and for moderate to severe depression either offer a choice oftreatments, or a first line treatment(s) and then go on to recommend a second grouping of therapies if the earlier options would not meet the child or young person’s needs or are unsuitable for their circumstances. This stresses the importance of tailoring the treatment to the requirements of the individual again.</p><p>Fourthly, the committee noted that the studies included in the evidence did not provide information on the effectiveness of these therapies for the subgroups listed above. As a result, they recommended that each of the therapies that were covered by research recommendations should include subgroup analyses that cover environment and family situation and neurodevelopmental disorders as part of the clinical trial process to provide evidence for future updates of the guideline.</p><p>Finally, the new recommendations cover the treatment of children and young people with depression after they have requested help. They do not address the problem that certain disadvantaged groups are less likely to seek help in the first place as consideration of barriers to seeking help was not part of this update. However, this issue will be considered for inclusion in future updates of this guideline.</p></div></div></div></div><div id="appendixesappgroup2"><h2 id="_appendixesappgroup2_">Appendices</h2><div id="ch2.appa"><h3>Appendix A. Review protocol</h3><div id="ch2.appa.s1"><h4>Review protocol for psychological interventions to manage depression in children and young people</h4><p id="ch2.appa.fm1"><a href="/books/NBK557360/bin/ch2-appa-fm1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Download PDF</a><span class="small"> (327K)</span></p></div></div><div id="ch2.appb"><h3>Appendix B. Methods</h3><div id="ch2.appb.s1"><h4>Incorporating published systematic reviews</h4><p>For all review questions where a literature search was undertaken looking for a particular study design, systematic reviews containing studies of that design were also included. All included studies from those systematic reviews were screened to identify any additional relevant primary studies not found as part of the initial search. Systematic reviews were not used as a source of data in this particular review and so no quality assessment was carried out.</p></div><div id="ch2.appb.s2"><h4>Evidence synthesis and meta-analyses</h4><p>Where possible, meta-analyses were conducted to combine the results of quantitative studies for each outcome. For continuous outcomes analysed as mean differences, where change from baseline data were reported in the trials and were accompanied by a measure of spread (for example standard deviation), these were extracted and used in the meta-analysis. Where measures of spread for change from baseline values were not reported, the corresponding values at study end were used and were combined with change from baseline values to produce summary estimates of effect. These studies were assessed to ensure that baseline values were balanced across the treatment groups; if there were significant differences at baseline these studies were not included in any meta-analysis and were reported separately. For continuous outcomes analysed as standardised mean differences (SMDs), where only baseline and final time point values were available, change from baseline standard deviations were estimated, assuming a correlation coefficient of 0.5.</p><p>For the pair-wise data analysis, continuous data was analysed as mean differences when all the data came from a single measure and as standardised mean differences if multiple measures of the same outcome were combined. In cases where data was reported for multiple scales for a single outcome, data was only extracted for a single scale per study. For each outcome the scales were ranked based on committee discussions about which scales were most clinically useful and the frequency of reporting using each scale in the included studies (see <a class="figpopup" href="/books/NBK557360/table/ch2.appq.tab1/?report=objectonly" target="object" rid-figpopup="figch2appqtab1" rid-ob="figobch2appqtab1">Table 42</a> in <a href="#ch2.appq">appendix Q</a> for the ranking of these scales).</p><p>In cases where SMDs were used they were back converted to a single scale to aid interpretation by the committee where possible. The choice of this scale was made based on committee input taking into account which scales are commonly used in the UK, which scales were prioritised for data extraction and had the most data, and which scales had associated MIDs that could help with interpretation of the results.</p><p>For the network meta-analyses (NMAs, see below), it was expected that using SMDs would be necessary, due to the larger number of studies included in each model. However, if a particular model only included data from one outcome scale then mean differences were used instead.</p></div><div id="ch2.appb.s3"><h4>Evidence of effectiveness of interventions</h4><div id="ch2.appb.s3.1"><h5>Quality assessment</h5><p>Individual RCTs and quasi-randomised controlled trials were quality assessed using the Cochrane Risk of Bias Tool. Each individual study was classified into one of the following three groups:
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<ul id="ch2.l201"><li id="ch2.lt629" class="half_rhythm"><div>Low risk of bias – The true effect size for the study is likely to be close to the estimated effect size.</div></li><li id="ch2.lt630" class="half_rhythm"><div>Moderate risk of bias – There is a possibility the true effect size for the study is substantially different to the estimated effect size.</div></li><li id="ch2.lt631" class="half_rhythm"><div>High risk of bias – It is likely the true effect size for the study is substantially different to the estimated effect size.</div></li></ul></p><p>Each individual study was also classified into one of three groups for directness, based on if there were concerns about the population, intervention, comparator and/or outcomes in the study and how directly these variables could address the specified review question. Studies were rated as follows:
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<ul id="ch2.l202"><li id="ch2.lt632" class="half_rhythm"><div>Direct – No important deviations from the protocol in population, intervention, comparator and/or outcomes.</div></li><li id="ch2.lt633" class="half_rhythm"><div>Partially indirect – Important deviations from the protocol in one of the population, intervention, comparator and/or outcomes.</div></li><li id="ch2.lt634" class="half_rhythm"><div>Indirect – Important deviations from the protocol in at least two of the following areas: population, intervention, comparator and/or outcomes.</div></li></ul></p></div><div id="ch2.appb.s3.2"><h5>Methods for combining intervention evidence</h5><p>Meta-analyses of interventional data were conducted with reference to the Cochrane Handbook for Systematic Reviews of Interventions (Higgins et al. 2011).</p><p>Where different studies presented continuous data measuring the same outcome but using different numerical scales (e.g. a 0–10 and a 0–100 visual analogue scale), these outcomes were all converted to the same scale before meta-analysis was conducted on the mean differences. Where outcomes measured the same underlying construct but used different instruments/metrics, data were analysed using standardised mean differences (Hedges’ g).</p><p>A pooled relative risk was calculated for dichotomous outcomes (using the Mantel–Haenszel method) reporting numbers of people having an event. Both relative and absolute risks were presented, with absolute risks calculated by applying the relative risk to the pooled risk in the comparator arm of the meta-analysis (all pooled trials).</p><p>Fixed- and random-effects models (der Simonian and Laird) were fitted for all syntheses, with the presented analysis dependent on the degree of heterogeneity in the assembled evidence. Fixed-effects models were the preferred choice to report, but in situations where the assumption of a shared mean for fixed-effects model were clearly not met random-effects results are presented.</p><p>Fixed-effects models were deemed to be inappropriate if one or both of the following conditions was met:
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<ul id="ch2.l203"><li id="ch2.lt635" class="half_rhythm"><div>Significant between study heterogeneity in methodology, population, intervention or comparator was identified by the reviewer in advance of data analysis. This decision was made and recorded before any data analysis was undertaken.</div></li><li id="ch2.lt636" class="half_rhythm"><div>The presence of significant statistical heterogeneity in the meta-analysis, defined as I<sup>2</sup>≥50%.</div></li></ul></p><p>However, in cases where the results from individual pre-specified subgroup analyses are less heterogeneous (with I<sup>2</sup> < 50%) the results from these subgroups will be reported using fixed effects models. This may lead to situations where pooled results are reported from random-effects models and subgroup results are reported from fixed-effects models.</p><p>In cases where subgroup analyses were performed, it was planned that pooled results would be reported in the GRADE tables, but the results from individual strata would only reported if there was evidence suggesting between subgroup heterogeneity. This is defined as a statistically significant test for subgroup interactions (at the 95% confidence level). Where no such evidence was identified, only pooled results were presented. (See the protocol deviation section of <a href="#ch2.s1.1.3">methods and processes</a> for relevant information on how subgroup analyses were actually reported in GRADE tables.)</p><p>In any meta-analyses where some (but not all) of the data came from studies at high risk of bias, a sensitivity analysis was conducted, excluding those studies from the analysis. Results from both the full and restricted meta-analyses are reported. Similarly, in any meta-analyses where some (but not all) of the data came from indirect studies, a sensitivity analysis was conducted, excluding those studies from the analysis.</p><p>Meta-analyses were performed in Cochrane Review Manager V5.3.</p></div><div id="ch2.appb.s3.3"><h5>Minimal clinically important differences (MIDs)</h5><p>The Core Outcome Measures in Effectiveness Trials (COMET) database was searched to identify published minimal clinically important difference thresholds relevant to this guideline. Identified MIDs were assessed to ensure they had been developed and validated in a methodologically rigorous way, and were applicable to the populations, interventions and outcomes specified in this guideline. In addition, the Guideline Committee were asked to prospectively specify any outcomes where they were aware of useful MIDs. The committee identified the MIDs shown in <a class="figpopup" href="/books/NBK557360/table/ch2.appb.tab1/?report=objectonly" target="object" rid-figpopup="figch2appbtab1" rid-ob="figobch2appbtab1">Table 9</a>.</p><p id="ch2.appb.tab1"><a href="/books/NBK557360/table/ch2.appb.tab1/?report=objectonly" target="object" rid-ob="figobch2appbtab1" class="figpopup">Table 9. Identified MIDs</a></p><div id="ch2.appb.s3.3.1"><h5>Specific use of MIDs in this guideline update</h5><p>This evidence review for this guideline was conducted using a modified version of the GRADE approach to rating the certainty of evidence in systematic reviews. This is part of a pilot project being undertaken by NICE, to examine the assessment of certainy of evidence in systematic reviews. Instead of using predefined MIDs to assess imprecision in GRADE tables, imprecision was assessed qualitatively during committee discussions. These discussions involved consideration of published MIDs where they exist, but the committee were also encouraged to make judgements of imprecision based on the 95% confidence intervals and sample sizes reported in the GRADE tables. This should enable judgements of clinical importance to be made in the context of wider decision making, taking into account evidence across all outcomes and analyses, including health economic analyses.</p><p>Committee discussions regarding the clinical importance of effects was recorded in the ‘benefits and harms’ section of the evidence review. In particular, this included consideration of whether the whole effect of a treatment (which may be felt across multiple independent outcome domains) would be likely to be clinically meaningful, rather than simply whether each individual sub outcome might be meaningful in isolation. The impact of imprecision on the recommendations was presented in the ‘quality of the evidence’ section of the committee discussion in the evidence review.</p></div></div><div id="ch2.appb.s3.4"><h5>GRADE for pairwise meta-analyses of interventional evidence</h5><p>GRADE was used to assess the quality of evidence for the selected outcomes as specified in ‘Developing NICE guidelines: the manual (2014)’. Data from all study designs was initially rated as high quality and the quality of the evidence for each outcome was downgraded or not from this initial point, based on the criteria given in <a class="figpopup" href="/books/NBK557360/table/ch2.appb.tab2/?report=objectonly" target="object" rid-figpopup="figch2appbtab2" rid-ob="figobch2appbtab2">Table 10</a>.</p><p>A modified form of GRADE that excluded consideration of imprecision was used for this guideline update. The reasons for this are discussed in the <a href="#ch2.appb.s3.3.1">specific use of MIDs section</a> above. As a result, the quality of the evidence presented in the GRADE tables was likely to be judged to be higher than normal as there is now one less domain to use for downgrading.</p><p id="ch2.appb.tab2"><a href="/books/NBK557360/table/ch2.appb.tab2/?report=objectonly" target="object" rid-ob="figobch2appbtab2" class="figpopup">Table 10. Rationale for downgrading quality of evidence for intervention studies</a></p><p>The quality of evidence for each outcome was upgraded if any of the following three conditions were met:
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<ul id="ch2.l204"><li id="ch2.lt637" class="half_rhythm"><div>Data from non-randomised studies showing an effect size sufficiently large that it cannot be explained by confounding alone.</div></li><li id="ch2.lt638" class="half_rhythm"><div>Data showing a dose-response gradient.</div></li><li id="ch2.lt639" class="half_rhythm"><div>Data where all plausible residual confounding is likely to increase our confidence in the effect estimate.</div></li></ul></p></div><div id="ch2.appb.s3.5"><h5>Publication bias</h5><p>Publication bias was assessed in two ways. First, if evidence of conducted but unpublished studies was identified during the review (e.g. conference abstracts, trial protocols or trial records without accompanying published data), available information on these unpublished studies was reported as part of the review. Secondly, where 10 or more studies were included as part of a single meta-analysis, a funnel plot was produced to graphically assess the potential for publication bias.</p></div><div id="ch2.appb.s3.6"><h5>Evidence statements for pairwise clinical data</h5><p>The evidence statements were grouped by outcome for ease of interpretation. They were divided into 2 categories as follows:
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<ul id="ch2.l205"><li id="ch2.lt640" class="half_rhythm"><div>We state that the evidence showed that there is an effect if the 95% CI does not cross the line of no effect.</div></li><li id="ch2.lt641" class="half_rhythm"><div>The evidence could not differentiate between comparators if the 95% CI crosses the line of no effect. If any of the boundaries of the 95% CI included 1.0 or 0.0 for RR or MD respectively this was considered to be within the line of no effect and the result was reported as ‘could not differentiate’.</div></li></ul></p><p>The evidence statements for an effect were further divided into 3 groups:
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<ul id="ch2.l206"><li id="ch2.lt642" class="half_rhythm"><div>Psychological interventions compared to controls where the psychological intervention was more effective than the control</div></li><li id="ch2.lt643" class="half_rhythm"><div>Psychological interventions compared to other psychological interventions and controls, where the first named intervention or control is more effective than the comparator for that outcome and time point.</div></li><li id="ch2.lt644" class="half_rhythm"><div>Psychological interventions compared to other psychological interventions, where one intervention was more effective than the other.</div></li></ul></p><p>The evidence statements included the quality of the evidence from the GRADE table based on the pooled results for each age group and depression severity group separately.</p></div></div><div id="ch2.appb.s4"><h4>Methods for combining direct and indirect evidence (network meta-analysis) for interventions</h4><p>Conventional ‘pairwise’ meta-analysis involves the statistical combination of direct evidence about pairs of interventions that originate from two or more separate studies (for example, where there are two or more studies comparing A vs B).</p><p>In situations where there are more than two interventions, pairwise meta-analysis of the direct evidence alone is of limited use. This is because multiple pairwise comparisons need to be performed to analyse each pair of interventions in the evidence, and these results can be difficult to interpret. Furthermore, direct evidence about interventions of interest may not be available. For example studies may compare A vs B and B vs C, but there may be no direct evidence comparing A vs C. Network meta-analysis overcomes these problems by combining all evidence into a single, internally consistent model, synthesising data from direct and indirect comparisons, and providing estimates of relative effectiveness for all comparators and the ranking of different interventions. Network meta-analyses were undertaken in all situations where the following three criteria were met:
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<ul id="ch2.l207"><li id="ch2.lt645" class="half_rhythm"><div>At least three treatment alternatives.</div></li><li id="ch2.lt646" class="half_rhythm"><div>A connected network which enabled valid estimates to be made.</div></li><li id="ch2.lt647" class="half_rhythm"><div>The aim of the review was to produce recommendations on the most effective option, rather than simply an unordered list of treatment alternatives.</div></li></ul></p><div id="ch2.appb.s4.1"><h5>Synthesis</h5><p>Hierarchical Bayesian Network Meta-Analysis (NMA) was performed using WinBUGS version 1.4.3. The models used reflected the recommendations of the NICE Decision Support Unit’s Technical Support Documents (TSDs) on evidence synthesis, particularly TSD 2 (‘A generalised linear modelling framework for pairwise and network meta-analysis of randomised controlled trials’; see <a href="http://www.nicedsu.org.uk" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.nicedsu.org.uk</a>) with additional models provided by the TSU (see <a href="#ch2.appr">appendix R</a> for NMA models).</p><p>Results were reported summarising at least 10,000 samples from the posterior distribution of each model, having first run and discarded at least 50,000 ‘burn-in’ iterations. Three separate chains with different initial values were used. In models where autocorrelation was detected thinning was carried out using a thin value of 10.</p><p>Non-informative prior distributions were used in all models. Unless otherwise specified, trial-specific baselines and treatment effects were assigned Normal (0,10000) priors, and the between-trial standard deviations used in random-effects models were given Uniform (0,5) priors for dichotomous outcomes and Uniform (0,10) priors for continuous outcomes.</p><p>Fixed- and random-effects models were explored for each outcome, with the final choice of model based on deviance information criterion (DIC): if DIC was at least 3 points lower for the random-effects model, it was preferred; otherwise, the fixed effects model was considered to provide an equivalent fit to the data in a more parsimonious analysis, and was preferred.</p><p>In any meta-analyses where some (but not all) of the data came from studies at high risk of bias, a sensitivity analysis was conducted, excluding those studies from the analysis. Results from both the full and restricted meta-analyses are reported. Similarly, in any meta-analyses where some (but not all) of the data came from studies that were partially or indirectly applicable compared to the protocol, a sensitivity analysis was conducted, excluding those studies from the analysis. Where sufficient studies were available, meta-regression was undertaken to explore the effect of study level covariates.</p></div><div id="ch2.appb.s4.2"><h5>Choice of outcomes for network meta-analysis</h5><p>Outcomes were selected from those listed in the review protocol, with the primary outcomes of level of function, depression symptoms following treatment, quality of life and remission being prioritised. Secondary outcomes were included if there were sufficient numbers of trials to form a connected network that included the majority of interventions. Additional models were run as required for outcomes needed to inform the economic analysis.</p><p>Subgroup analyses were carried out for severity of depression by running separate models that included studies with participants with mild or moderate-to-severe depression. Subgroup analyses were carried out by age (children aged 5–11, young people aged 12–18) where there were sufficient numbers of trials and studies to form a connected network and for cases where this network would provide additional information to the pairwise analysis. For example, in cases where the NMA would only provide additional information about the effectiveness of 2 control interventions the NMA was not considered useful for decision making and was not carried out.</p></div><div id="ch2.appb.s4.3"><h5>Modified GRADE for network meta-analyses</h5><p>A modified version of the standard GRADE approach for pairwise interventions was used to assess the quality of evidence across the network meta-analyses undertaken (<a class="figpopup" href="/books/NBK557360/table/ch2.appb.tab3/?report=objectonly" target="object" rid-figpopup="figch2appbtab3" rid-ob="figobch2appbtab3">Table 11</a>). While most criteria for pairwise meta-analyses still apply, it is important to adapt some of the criteria to take into consideration additional factors, such as how each ‘link’ or pairwise comparison within the network applies to the others. As a result, the following was used when modifying the GRADE framework to a network meta-analysis. It is designed to provide a single overall quality rating for an NMA, which can then be combined with pairwise quality ratings for individual comparisons (if appropriate), to judge the overall strength of evidence for each comparison.</p><p id="ch2.appb.tab3"><a href="/books/NBK557360/table/ch2.appb.tab3/?report=objectonly" target="object" rid-ob="figobch2appbtab3" class="figpopup">Table 11. Rationale for downgrading quality of evidence for NMAs</a></p></div><div id="ch2.appb.s4.4"><h5>Evidence statements</h5><p>The evidence statements were grouped by severity of depression and outcome for ease of interpretation. They were divided into 2 categories as follows:
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<ul id="ch2.l208"><li id="ch2.lt648" class="half_rhythm"><div>We state that the evidence showed that there is an effect if the 95% credible interval (CrI) does not cross the line of no effect.</div></li><li id="ch2.lt649" class="half_rhythm"><div>The evidence could not differentiate between comparators if the 95% CrI crosses the line of no effect. If any of the boundaries of the 95% Crl included 1.0 for RR or 0.0 for MD, this was considered to be within the line of no effect and the result was reported as ‘could not differentiate’.</div></li></ul></p><p>NMA evidence statements included the quality of the network as a whole and only listed the results of interventions compared to controls or each other. The relative effectiveness of controls compared to each other were not presented as they were not viable treatment options and, as a result, would not be useful for decision making.</p></div></div></div><div id="ch2.appc"><h3>Appendix C. Literature search strategies</h3><div id="ch2.appc.s1"><h4>Q1a What are the most effective psychological interventions for children and young people with depression? (Update of the search strategy used in the 2015 version of the guideline)</h4><p>Sources searched to identify the clinical evidence:
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<div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appctab1"><a href="/books/NBK557360/table/ch2.appc.tab1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appctab1" rid-ob="figobch2appctab1"><img class="small-thumb" src="/books/NBK557360/table/ch2.appc.tab1/?report=thumb" src-large="/books/NBK557360/table/ch2.appc.tab1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appc.tab1"><a href="/books/NBK557360/table/ch2.appc.tab1/?report=objectonly" target="object" rid-ob="figobch2appctab1">Table</a></h4></div></div></p><p>The MEDLINE search strategy is presented below. This was translated for use in all of the other databases listed. The aim of the search was to identify evidence for the clinical question being asked. Randomised Controlled Trial and Systematic Review filters were used to identify the study designs specified in the Review Protocol.</p><ol id="ch2.l209"><li id="ch2.lt650" class="half_rhythm"><div>Depression/</div></li><li id="ch2.lt651" class="half_rhythm"><div>exp Depressive Disorder/</div></li><li id="ch2.lt652" class="half_rhythm"><div>(depress* or dysthymi* or dysphori* or melanchol* or sadness).tw.</div></li><li id="ch2.lt653" class="half_rhythm"><div>("seasonal affective disorder*" or sad).tw.</div></li><li id="ch2.lt654" class="half_rhythm"><div>1 or 2 or 3 or 4 (458667)</div></li><li id="ch2.lt655" class="half_rhythm"><div>exp Cognitive Therapy/</div></li><li id="ch2.lt656" class="half_rhythm"><div>Therapy, Computer-Assisted/</div></li><li id="ch2.lt657" class="half_rhythm"><div>(((cogniti* or computer*) adj4 (therap* or behavio* or interven*)) or cbt* or ccbt*).tw.</div></li><li id="ch2.lt658" class="half_rhythm"><div>exp Psychotherapy/</div></li><li id="ch2.lt659" class="half_rhythm"><div>(psychotherap* or logotherap*).tw.</div></li><li id="ch2.lt660" class="half_rhythm"><div>((self adj4 model*) or sm).tw.</div></li><li id="ch2.lt661" class="half_rhythm"><div>Relaxation Therapy/</div></li><li id="ch2.lt662" class="half_rhythm"><div>(relax* adj4 (therap* or techni*)).tw.</div></li><li id="ch2.lt663" class="half_rhythm"><div>Behavior Therapy/</div></li><li id="ch2.lt664" class="half_rhythm"><div>((behavi* or condition*) adj4 (therap* or modifi*)).tw.</div></li><li id="ch2.lt665" class="half_rhythm"><div>((social adj4 skill* adj4 train*) or sst).tw.</div></li><li id="ch2.lt666" class="half_rhythm"><div>Family Therapy/</div></li><li id="ch2.lt667" class="half_rhythm"><div>Psychotherapy, group/</div></li><li id="ch2.lt668" class="half_rhythm"><div>((famil* or group) adj4 (therap* or techni*)).tw.</div></li><li id="ch2.lt669" class="half_rhythm"><div>((control adj4 enhancement adj4 (training or therap*)) or pascet).tw.</div></li><li id="ch2.lt670" class="half_rhythm"><div>((((non adj4 directive) or nondirective) adj4 supportive adj4 therap*) or ndst).tw.</div></li><li id="ch2.lt671" class="half_rhythm"><div>(((client adj4 cent*) or rogerian) adj4 therap*).tw.</div></li><li id="ch2.lt672" class="half_rhythm"><div>“guided self help”.tw.</div></li><li id="ch2.lt673" class="half_rhythm"><div>Self care/px or self care/mt</div></li><li id="ch2.lt674" class="half_rhythm"><div>Mindfulness/</div></li><li id="ch2.lt675" class="half_rhythm"><div>mindfulness.tw.</div></li><li id="ch2.lt676" class="half_rhythm"><div>or/6–26</div></li><li id="ch2.lt677" class="half_rhythm"><div>infan*.mp,so.</div></li><li id="ch2.lt678" class="half_rhythm"><div>minor.mp,so.</div></li><li id="ch2.lt679" class="half_rhythm"><div>minors*.mp,so.</div></li><li id="ch2.lt680" class="half_rhythm"><div>boy.mp,so.</div></li><li id="ch2.lt681" class="half_rhythm"><div>boys.mp,so.</div></li><li id="ch2.lt682" class="half_rhythm"><div>boyfriend*.mp,so.</div></li><li id="ch2.lt683" class="half_rhythm"><div>boyhood.mp,so.</div></li><li id="ch2.lt684" class="half_rhythm"><div>girl*.mp,so.</div></li><li id="ch2.lt685" class="half_rhythm"><div>kid.mp,so.</div></li><li id="ch2.lt686" class="half_rhythm"><div>kids.mp,so.</div></li><li id="ch2.lt687" class="half_rhythm"><div>child*.mp,so.</div></li><li id="ch2.lt688" class="half_rhythm"><div>adolescen*.mp,so.</div></li><li id="ch2.lt689" class="half_rhythm"><div>juvenil*.mp,so.</div></li><li id="ch2.lt690" class="half_rhythm"><div>youth*.mp,so.</div></li><li id="ch2.lt691" class="half_rhythm"><div>teen*.mp,so.</div></li><li id="ch2.lt692" class="half_rhythm"><div>under*age*.mp,so.</div></li><li id="ch2.lt693" class="half_rhythm"><div>pubescen*.mp,so.</div></li><li id="ch2.lt694" class="half_rhythm"><div>exp pediatrics/</div></li><li id="ch2.lt695" class="half_rhythm"><div>pediatric*.mp,so.</div></li><li id="ch2.lt696" class="half_rhythm"><div>paediatric*.mp,so.</div></li><li id="ch2.lt697" class="half_rhythm"><div>peadiatric*.mp,so.</div></li><li id="ch2.lt698" class="half_rhythm"><div>school*.mp,so.</div></li><li id="ch2.lt699" class="half_rhythm"><div>or/28–49</div></li><li id="ch2.lt700" class="half_rhythm"><div>5 and 27 and 50</div></li><li id="ch2.lt701" class="half_rhythm"><div>Meta-Analysis.pt.</div></li><li id="ch2.lt702" class="half_rhythm"><div>Network Meta-Analysis/</div></li><li id="ch2.lt703" class="half_rhythm"><div>Meta-Analysis as Topic/</div></li><li id="ch2.lt704" class="half_rhythm"><div>Review.pt.</div></li><li id="ch2.lt705" class="half_rhythm"><div>exp Review Literature as Topic/</div></li><li id="ch2.lt706" class="half_rhythm"><div>(metaanaly$ or metanaly$ or (meta adj3 analy$)).tw.</div></li><li id="ch2.lt707" class="half_rhythm"><div>(review$ or overview$).ti.</div></li><li id="ch2.lt708" class="half_rhythm"><div>(systematic$ adj5 (review$ or overview$)).tw.</div></li><li id="ch2.lt709" class="half_rhythm"><div>((quantitative$ or qualitative$) adj5 (review$ or overview$)).tw.</div></li><li id="ch2.lt710" class="half_rhythm"><div>((studies or trial$) adj2 (review$ or overview$)).tw.</div></li><li id="ch2.lt711" class="half_rhythm"><div>(integrat$ adj3 (research or review$ or literature)).tw.</div></li><li id="ch2.lt712" class="half_rhythm"><div>(pool$ adj2 (analy$ or data)).tw.</div></li><li id="ch2.lt713" class="half_rhythm"><div>(handsearch$ or (hand adj3 search$)).tw.</div></li><li id="ch2.lt714" class="half_rhythm"><div>(manual$ adj3 search$).tw.</div></li><li id="ch2.lt715" class="half_rhythm"><div>or/52–65</div></li><li id="ch2.lt716" class="half_rhythm"><div>animals/ not humans/</div></li><li id="ch2.lt717" class="half_rhythm"><div>66 not 67</div></li><li id="ch2.lt718" class="half_rhythm"><div>Randomized Controlled Trial.pt.</div></li><li id="ch2.lt719" class="half_rhythm"><div>Controlled Clinical Trial.pt.</div></li><li id="ch2.lt720" class="half_rhythm"><div>Clinical Trial.pt.</div></li><li id="ch2.lt721" class="half_rhythm"><div>exp Clinical Trials as Topic/</div></li><li id="ch2.lt722" class="half_rhythm"><div>Placebos/</div></li><li id="ch2.lt723" class="half_rhythm"><div>Random Allocation/</div></li><li id="ch2.lt724" class="half_rhythm"><div>Double-Blind Method/</div></li><li id="ch2.lt725" class="half_rhythm"><div>Single-Blind Method/</div></li><li id="ch2.lt726" class="half_rhythm"><div>Cross-Over Studies/</div></li><li id="ch2.lt727" class="half_rhythm"><div>((random$ or control$ or clinical$) adj3 (trial$ or stud$)).tw.</div></li><li id="ch2.lt728" class="half_rhythm"><div>(random$ adj3 allocat$).tw.</div></li><li id="ch2.lt729" class="half_rhythm"><div>placebo$.tw.</div></li><li id="ch2.lt730" class="half_rhythm"><div>((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw.</div></li><li id="ch2.lt731" class="half_rhythm"><div>(crossover$ or (cross adj over$)).tw.</div></li><li id="ch2.lt732" class="half_rhythm"><div>or/69–82</div></li><li id="ch2.lt733" class="half_rhythm"><div>animals/ not humans/</div></li><li id="ch2.lt734" class="half_rhythm"><div>83 not 84</div></li><li id="ch2.lt735" class="half_rhythm"><div>68 or 85</div></li><li id="ch2.lt736" class="half_rhythm"><div>51 and 86</div></li><li id="ch2.lt737" class="half_rhythm"><div>limit 87 to english language</div></li><li id="ch2.lt738" class="half_rhythm"><div>(2014* or 2015* or 2016* or 2017* or 2018*).ed.</div></li><li id="ch2.lt739" class="half_rhythm"><div>88 and 89</div></li></ol></div><div id="ch2.appc.s2"><h4>Q1b What are the most effective psychological interventions for children and young people with depression? (search for interventions not included in previous versions of the guideline)</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appctab2"><a href="/books/NBK557360/table/ch2.appc.tab2/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appctab2" rid-ob="figobch2appctab2"><img class="small-thumb" src="/books/NBK557360/table/ch2.appc.tab2/?report=thumb" src-large="/books/NBK557360/table/ch2.appc.tab2/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appc.tab2"><a href="/books/NBK557360/table/ch2.appc.tab2/?report=objectonly" target="object" rid-ob="figobch2appctab2">Table</a></h4></div></div><p>The MEDLINE search strategy is presented below. This was translated for use in all of the other databases listed. The aim of the search was to identify evidence for the clinical question being asked. Randomised Controlled Trial and Systematic Review filters were used to identify the study designs specified in the Review Protocol.</p><ol id="ch2.l210"><li id="ch2.lt740" class="half_rhythm"><div>Depression/</div></li><li id="ch2.lt741" class="half_rhythm"><div>exp Depressive Disorder/</div></li><li id="ch2.lt742" class="half_rhythm"><div>(depress* or dysthymi* or dysphori* or melanchol* or sadness).tw.</div></li><li id="ch2.lt743" class="half_rhythm"><div>("seasonal affective disorder*" or sad).tw.</div></li><li id="ch2.lt744" class="half_rhythm"><div>Mood Disorders/</div></li><li id="ch2.lt745" class="half_rhythm"><div>((mood* or affectiv*) adj (disorder* or illness* or neuro*)).tw.</div></li><li id="ch2.lt746" class="half_rhythm"><div>Cyclothymic Disorder/</div></li><li id="ch2.lt747" class="half_rhythm"><div>cyclothym*.tw.</div></li><li id="ch2.lt748" class="half_rhythm"><div>exp bereavement/</div></li><li id="ch2.lt749" class="half_rhythm"><div>(grief* or griev* or mourn* or bereav* or sorrow*).tw.</div></li><li id="ch2.lt750" class="half_rhythm"><div>Anhedonia/</div></li><li id="ch2.lt751" class="half_rhythm"><div>anhedon*.tw.</div></li><li id="ch2.lt752" class="half_rhythm"><div>or/1–12</div></li><li id="ch2.lt753" class="half_rhythm"><div>infan*.mp,so.</div></li><li id="ch2.lt754" class="half_rhythm"><div>minor.mp,so.</div></li><li id="ch2.lt755" class="half_rhythm"><div>minors*.mp,so.</div></li><li id="ch2.lt756" class="half_rhythm"><div>boy.mp,so.</div></li><li id="ch2.lt757" class="half_rhythm"><div>boys.mp,so.</div></li><li id="ch2.lt758" class="half_rhythm"><div>boyfriend*.mp,so.</div></li><li id="ch2.lt759" class="half_rhythm"><div>boyhood.mp,so.</div></li><li id="ch2.lt760" class="half_rhythm"><div>girl*.mp,so.</div></li><li id="ch2.lt761" class="half_rhythm"><div>kid.mp,so.</div></li><li id="ch2.lt762" class="half_rhythm"><div>kids.mp,so.</div></li><li id="ch2.lt763" class="half_rhythm"><div>child*.mp,so.</div></li><li id="ch2.lt764" class="half_rhythm"><div>adolescen*.mp,so.</div></li><li id="ch2.lt765" class="half_rhythm"><div>juvenil*.mp,so.</div></li><li id="ch2.lt766" class="half_rhythm"><div>youth*.mp,so.</div></li><li id="ch2.lt767" class="half_rhythm"><div>teen*.mp,so.</div></li><li id="ch2.lt768" class="half_rhythm"><div>under*age*.mp,so.</div></li><li id="ch2.lt769" class="half_rhythm"><div>pubescen*.mp,so.</div></li><li id="ch2.lt770" class="half_rhythm"><div>exp pediatrics/</div></li><li id="ch2.lt771" class="half_rhythm"><div>pediatric*.mp,so.</div></li><li id="ch2.lt772" class="half_rhythm"><div>paediatric*.mp,so.</div></li><li id="ch2.lt773" class="half_rhythm"><div>peadiatric*.mp,so.</div></li><li id="ch2.lt774" class="half_rhythm"><div>school*.mp,so.</div></li><li id="ch2.lt775" class="half_rhythm"><div>or/14–35</div></li><li id="ch2.lt776" class="half_rhythm"><div>13 and 36</div></li><li id="ch2.lt777" class="half_rhythm"><div>psychosocial support systems/</div></li><li id="ch2.lt778" class="half_rhythm"><div>(psychosocial* or psycho-social* or “psycho social*”).tw.</div></li><li id="ch2.lt779" class="half_rhythm"><div>(psychoeducat* or psycho-educat* or “psycho educat*”).tw.</div></li><li id="ch2.lt780" class="half_rhythm"><div>Mobile Applications/</div></li><li id="ch2.lt781" class="half_rhythm"><div>(app or apps).tw.</div></li><li id="ch2.lt782" class="half_rhythm"><div>((mobile* or phone* or smartphone* or smart-phone* or “smart* phone*” or cellphone* or cell-phone* or “cell phone*” or iphone* or i-phone* or “i phone*” or ipad* or i-pad* or “i pad*” or tablet* or apple* or ios or android* or windows or blackberry* or portable or electronic or device* or digital or software or online or internet or web or medical or health) adj application*).tw.</div></li><li id="ch2.lt783" class="half_rhythm"><div>(digital health or digihealth or “digi health” or mobile health or mhealth or ehealth or m-health or e-health or “m health” or “e health”).tw.</div></li><li id="ch2.lt784" class="half_rhythm"><div>behavi* activat*.tw.</div></li><li id="ch2.lt785" class="half_rhythm"><div>Eye Movement Desensitization Reprocessing/</div></li><li id="ch2.lt786" class="half_rhythm"><div>(eye* adj4 (desens* or reprocess*)).tw.</div></li><li id="ch2.lt787" class="half_rhythm"><div>exp Counseling/</div></li><li id="ch2.lt788" class="half_rhythm"><div>(counselling or counseling).tw.</div></li><li id="ch2.lt789" class="half_rhythm"><div>Bibliotherapy/</div></li><li id="ch2.lt790" class="half_rhythm"><div>(bibliotherap* or biblio-therap* or “biblio therap*”).tw.</div></li><li id="ch2.lt791" class="half_rhythm"><div>(systemic adj4 (therap* or psycho* or interven* or manag* or support* or treat*)).tw.</div></li><li id="ch2.lt792" class="half_rhythm"><div>Problem solving/</div></li><li id="ch2.lt793" class="half_rhythm"><div>problem* solv*.tw.</div></li><li id="ch2.lt794" class="half_rhythm"><div>solution* focus* therap*.tw.</div></li><li id="ch2.lt795" class="half_rhythm"><div>solution* focus* brief therap*.tw.</div></li><li id="ch2.lt796" class="half_rhythm"><div>(dialecti* behavio* therap* or DBT).tw.</div></li><li id="ch2.lt797" class="half_rhythm"><div>(interpersonal adj4 (therap* or psycho* or interven* or manag* or support* or treat*)).tw.</div></li><li id="ch2.lt798" class="half_rhythm"><div>exp Sensory Art Therapies/</div></li><li id="ch2.lt799" class="half_rhythm"><div>((sensory or creativ* or art or music* or danc* or drama* or play* or sandplay* or sandplay* or “sand play*”) adj4 (therap* or psycho* or interven* or manag* or support* or treat*)).tw.</div></li><li id="ch2.lt800" class="half_rhythm"><div>exp Psychodrama/</div></li><li id="ch2.lt801" class="half_rhythm"><div>(psychodrama* or psycho-drama* or “psycho* drama*” or roleplay* or role-play* or “role* play*”).tw.</div></li><li id="ch2.lt802" class="half_rhythm"><div>Psychoanalysis/</div></li><li id="ch2.lt803" class="half_rhythm"><div>exp Psychoanalytic Therapy/</div></li><li id="ch2.lt804" class="half_rhythm"><div>(psychoanaly* or psycho-analy* or “psycho* analy*”).tw.</div></li><li id="ch2.lt805" class="half_rhythm"><div>or/38–65</div></li><li id="ch2.lt806" class="half_rhythm"><div>37 and 66</div></li><li id="ch2.lt807" class="half_rhythm"><div>Meta-Analysis.pt.</div></li><li id="ch2.lt808" class="half_rhythm"><div>Network Meta-Analysis/</div></li><li id="ch2.lt809" class="half_rhythm"><div>Meta-Analysis as Topic/</div></li><li id="ch2.lt810" class="half_rhythm"><div>Review.pt.</div></li><li id="ch2.lt811" class="half_rhythm"><div>exp Review Literature as Topic/</div></li><li id="ch2.lt812" class="half_rhythm"><div>(metaanaly$ or metanaly$ or (meta adj3 analy$)).tw.</div></li><li id="ch2.lt813" class="half_rhythm"><div>(review$ or overview$).ti.</div></li><li id="ch2.lt814" class="half_rhythm"><div>(systematic$ adj5 (review$ or overview$)).tw.</div></li><li id="ch2.lt815" class="half_rhythm"><div>((quantitative$ or qualitative$) adj5 (review$ or overview$)).tw.</div></li><li id="ch2.lt816" class="half_rhythm"><div>((studies or trial$) adj2 (review$ or overview$)).tw.</div></li><li id="ch2.lt817" class="half_rhythm"><div>(integrat$ adj3 (research or review$ or literature)).tw.</div></li><li id="ch2.lt818" class="half_rhythm"><div>(pool$ adj2 (analy$ or data)).tw.</div></li><li id="ch2.lt819" class="half_rhythm"><div>(handsearch$ or (hand adj3 search$)).tw.</div></li><li id="ch2.lt820" class="half_rhythm"><div>(manual$ adj3 search$).tw.</div></li><li id="ch2.lt821" class="half_rhythm"><div>or/68–81</div></li><li id="ch2.lt822" class="half_rhythm"><div>animals/ not humans/</div></li><li id="ch2.lt823" class="half_rhythm"><div>82 not 83</div></li><li id="ch2.lt824" class="half_rhythm"><div>Randomized Controlled Trial.pt.</div></li><li id="ch2.lt825" class="half_rhythm"><div>Controlled Clinical Trial.pt.</div></li><li id="ch2.lt826" class="half_rhythm"><div>Clinical Trial.pt.</div></li><li id="ch2.lt827" class="half_rhythm"><div>exp Clinical Trials as Topic/</div></li><li id="ch2.lt828" class="half_rhythm"><div>Placebos/</div></li><li id="ch2.lt829" class="half_rhythm"><div>Random Allocation/</div></li><li id="ch2.lt830" class="half_rhythm"><div>Double-Blind Method/</div></li><li id="ch2.lt831" class="half_rhythm"><div>Single-Blind Method/</div></li><li id="ch2.lt832" class="half_rhythm"><div>Cross-Over Studies/</div></li><li id="ch2.lt833" class="half_rhythm"><div>((random$ or control$ or clinical$) adj3 (trial$ or stud$)).tw.</div></li><li id="ch2.lt834" class="half_rhythm"><div>(random$ adj3 allocat$).tw.</div></li><li id="ch2.lt835" class="half_rhythm"><div>placebo$.tw.</div></li><li id="ch2.lt836" class="half_rhythm"><div>((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).tw.</div></li><li id="ch2.lt837" class="half_rhythm"><div>(crossover$ or (cross adj over$)).tw.</div></li><li id="ch2.lt838" class="half_rhythm"><div>or/85–98</div></li><li id="ch2.lt839" class="half_rhythm"><div>animals/ not humans/</div></li><li id="ch2.lt840" class="half_rhythm"><div>99 not 100</div></li><li id="ch2.lt841" class="half_rhythm"><div>84 or 101</div></li><li id="ch2.lt842" class="half_rhythm"><div>67 and 102</div></li><li id="ch2.lt843" class="half_rhythm"><div>limit 103 to english language</div></li></ol></div><div id="ch2.appc.s3"><h4>Economic evaluations and quality of life data</h4><p>Sources searched to identify economic evaluations:
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<div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appctab3"><a href="/books/NBK557360/table/ch2.appc.tab3/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appctab3" rid-ob="figobch2appctab3"><img class="small-thumb" src="/books/NBK557360/table/ch2.appc.tab3/?report=thumb" src-large="/books/NBK557360/table/ch2.appc.tab3/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appc.tab3"><a href="/books/NBK557360/table/ch2.appc.tab3/?report=objectonly" target="object" rid-ob="figobch2appctab3">Table</a></h4></div></div></p><p>Search filters to retrieve economic evaluations and quality of life papers were appended to both of the search strategies (RQ1a and RQ1b) to identify relevant evidence. The MEDLINE economic evaluations and quality of life search filters are presented below. They were translated for use in MEDLINE in Process and Embase databases.</p><p>
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<b>
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<u>Economic evaluations</u>
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</b>
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</p><ol id="ch2.l211"><li id="ch2.lt844" class="half_rhythm"><div>Economics/</div></li><li id="ch2.lt845" class="half_rhythm"><div>exp “Costs and Cost Analysis”/</div></li><li id="ch2.lt846" class="half_rhythm"><div>Economics, Dental/</div></li><li id="ch2.lt847" class="half_rhythm"><div>exp Economics, Hospital/</div></li><li id="ch2.lt848" class="half_rhythm"><div>exp Economics, Medical/</div></li><li id="ch2.lt849" class="half_rhythm"><div>Economics, Nursing/</div></li><li id="ch2.lt850" class="half_rhythm"><div>Economics, Pharmaceutical/</div></li><li id="ch2.lt851" class="half_rhythm"><div>Budgets/</div></li><li id="ch2.lt852" class="half_rhythm"><div>exp Models, Economic/</div></li><li id="ch2.lt853" class="half_rhythm"><div>Markov Chains/</div></li><li id="ch2.lt854" class="half_rhythm"><div>Monte Carlo Method/</div></li><li id="ch2.lt855" class="half_rhythm"><div>Decision Trees/</div></li><li id="ch2.lt856" class="half_rhythm"><div>econom$.tw.</div></li><li id="ch2.lt857" class="half_rhythm"><div>cba.tw.</div></li><li id="ch2.lt858" class="half_rhythm"><div>cea.tw.</div></li><li id="ch2.lt859" class="half_rhythm"><div>cua.tw.</div></li><li id="ch2.lt860" class="half_rhythm"><div>markov$.tw.</div></li><li id="ch2.lt861" class="half_rhythm"><div>(monte adj carlo).tw.</div></li><li id="ch2.lt862" class="half_rhythm"><div>(decision adj3 (tree$ or analys$)).tw.</div></li><li id="ch2.lt863" class="half_rhythm"><div>(cost or costs or costing$ or costly or costed).tw.</div></li><li id="ch2.lt864" class="half_rhythm"><div>(price$ or pricing$).tw.</div></li><li id="ch2.lt865" class="half_rhythm"><div>budget$.tw.</div></li><li id="ch2.lt866" class="half_rhythm"><div>expenditure$.tw.</div></li><li id="ch2.lt867" class="half_rhythm"><div>(value adj3 (money or monetary)).tw.</div></li><li id="ch2.lt868" class="half_rhythm"><div>(pharmacoeconomic$ or (pharmaco adj economic$)).tw.</div></li><li id="ch2.lt869" class="half_rhythm"><div>or/1–25</div></li></ol><p>
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<b>
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<u>Quality of Life</u>
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</b>
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</p><ol id="ch2.l212"><li id="ch2.lt870" class="half_rhythm"><div>“Quality of Life”/</div></li><li id="ch2.lt871" class="half_rhythm"><div>quality of life.tw.</div></li><li id="ch2.lt872" class="half_rhythm"><div>“Value of Life”/</div></li><li id="ch2.lt873" class="half_rhythm"><div>Quality-Adjusted Life Years/</div></li><li id="ch2.lt874" class="half_rhythm"><div>quality adjusted life.tw.</div></li><li id="ch2.lt875" class="half_rhythm"><div>(qaly$ or qald$ or qale$ or qtime$).tw.</div></li><li id="ch2.lt876" class="half_rhythm"><div>disability adjusted life.tw.</div></li><li id="ch2.lt877" class="half_rhythm"><div>daly$.tw.</div></li><li id="ch2.lt878" class="half_rhythm"><div>Health Status Indicators/</div></li><li id="ch2.lt879" class="half_rhythm"><div>(sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.</div></li><li id="ch2.lt880" class="half_rhythm"><div>(sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.</div></li><li id="ch2.lt881" class="half_rhythm"><div>(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.</div></li><li id="ch2.lt882" class="half_rhythm"><div>(sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw.</div></li><li id="ch2.lt883" class="half_rhythm"><div>(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.</div></li><li id="ch2.lt884" class="half_rhythm"><div>(euroqol or euro qol or eq5d or eq 5d).tw.</div></li><li id="ch2.lt885" class="half_rhythm"><div>(qol or hql or hqol or hrqol).tw.</div></li><li id="ch2.lt886" class="half_rhythm"><div>(hye or hyes).tw.</div></li><li id="ch2.lt887" class="half_rhythm"><div>health$ year$ equivalent$.tw.</div></li><li id="ch2.lt888" class="half_rhythm"><div>utilit$.tw.</div></li><li id="ch2.lt889" class="half_rhythm"><div>(hui or hui1 or hui2 or hui3).tw.</div></li><li id="ch2.lt890" class="half_rhythm"><div>disutili$.tw.</div></li><li id="ch2.lt891" class="half_rhythm"><div>rosser.tw.</div></li><li id="ch2.lt892" class="half_rhythm"><div>quality of wellbeing.tw.</div></li><li id="ch2.lt893" class="half_rhythm"><div>quality of well-being.tw.</div></li><li id="ch2.lt894" class="half_rhythm"><div>qwb.tw.</div></li><li id="ch2.lt895" class="half_rhythm"><div>willingness to pay.tw.</div></li><li id="ch2.lt896" class="half_rhythm"><div>standard gamble$.tw.</div></li><li id="ch2.lt897" class="half_rhythm"><div>time trade off.tw.</div></li><li id="ch2.lt898" class="half_rhythm"><div>time tradeoff.tw.</div></li><li id="ch2.lt899" class="half_rhythm"><div>tto.tw.</div></li><li id="ch2.lt900" class="half_rhythm"><div>or/1–30</div></li></ol></div></div><div id="ch2.appd"><h3>Appendix D. Clinical evidence study selection</h3><div id="ch2.appd.fig1" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appdf1&p=BOOKS&id=557360_ch2appdf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK557360/bin/ch2appdf1.jpg" alt="Image ch2appdf1" class="tileshop" title="Click on image to zoom" /></a></div></div></div><div id="ch2.appe"><h3>Appendix E. Evidence tables</h3><div id="ch2.appe.s1"><h4>Clinical evidence</h4><div id="ch2.appe.s1.1"><h5>Network meta-analyses</h5><p id="ch2.appe.et1"><a href="/books/NBK557360/bin/ch2-appe-et1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Download PDF</a><span class="small"> (211K)</span></p></div><div id="ch2.appe.s1.2"><h5>Randomised controlled trials</h5><p id="ch2.appe.et2"><a href="/books/NBK557360/bin/ch2-appe-et2.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Download PDF</a><span class="small"> (1.4M)</span></p></div></div></div><div id="ch2.appf"><h3>Appendix F. Forest plots</h3><p>RCTs were divided into those which recruited children and young people with depression symptoms (mild depression), and those which recruited children and young people with a depressive disorder diagnosis (moderate to severe depression). Forest plots show severity of depression based on the recruitment criteria (depression symptoms or depressive disorder diagnosis).</p><div id="ch2.appf.s1"><h4>Mild depression</h4><div id="ch2.appf.s1.1"><h5>Age 5–11 years</h5><div id="ch2.appf.s1.1.1"><h5>Group CBT v waiting list/no treatment</h5><p id="ch2.appf.fig1"><a href="/books/NBK557360/figure/ch2.appf.fig1/?report=objectonly" target="object" rid-ob="figobch2appffig1" class="figpopup">Figure 1. Depression symptoms (see footnotes for scales), Post-treatment</a></p></div></div><div id="ch2.appf.s1.2"><h5>Age 12–18 years</h5><div id="ch2.appf.s1.2.1"><h5>Individual CBT vs waiting list/no treatment</h5><p id="ch2.appf.fig2"><a href="/books/NBK557360/figure/ch2.appf.fig2/?report=objectonly" target="object" rid-ob="figobch2appffig2" class="figpopup">Figure 2. Depression symptoms (see footnotes for scales), Post-treatment</a></p><p id="ch2.appf.fig3"><a href="/books/NBK557360/figure/ch2.appf.fig3/?report=objectonly" target="object" rid-ob="figobch2appffig3" class="figpopup">Figure 3. Depression symptoms (see footnotes for scales), ≤6 months</a></p><p id="ch2.appf.fig4"><a href="/books/NBK557360/figure/ch2.appf.fig4/?report=objectonly" target="object" rid-ob="figobch2appffig4" class="figpopup">Figure 4. Discontinuation for any reason</a></p></div><div id="ch2.appf.s1.2.2"><h5>Individual CBT vs usual care</h5><p id="ch2.appf.fig5"><a href="/books/NBK557360/figure/ch2.appf.fig5/?report=objectonly" target="object" rid-ob="figobch2appffig5" class="figpopup">Figure 5. Depression symptoms (see footnotes for scales), Post-treatment</a></p><p id="ch2.appf.fig6"><a href="/books/NBK557360/figure/ch2.appf.fig6/?report=objectonly" target="object" rid-ob="figobch2appffig6" class="figpopup">Figure 6. Depression symptoms (see footnotes for scales), ≤6 months</a></p><p id="ch2.appf.fig7"><a href="/books/NBK557360/figure/ch2.appf.fig7/?report=objectonly" target="object" rid-ob="figobch2appffig7" class="figpopup">Figure 7. Discontinuation for any reason</a></p></div><div id="ch2.appf.s1.2.3"><h5>Computer CBT vs attention control</h5><p id="ch2.appf.fig8"><a href="/books/NBK557360/figure/ch2.appf.fig8/?report=objectonly" target="object" rid-ob="figobch2appffig8" class="figpopup">Figure 8. Depression symptoms (see footnote for scales), Post-treatment</a></p><p id="ch2.appf.fig9"><a href="/books/NBK557360/figure/ch2.appf.fig9/?report=objectonly" target="object" rid-ob="figobch2appffig9" class="figpopup">Figure 9. Depression symptoms (see footnote for scales), ≤6 months</a></p><p id="ch2.appf.fig10"><a href="/books/NBK557360/figure/ch2.appf.fig10/?report=objectonly" target="object" rid-ob="figobch2appffig10" class="figpopup">Figure 10. Sensitivity analysis excluding studies with a high risk of bias: Depression symptoms (see footnotes for scales), ≤6 months</a></p><p id="ch2.appf.fig11"><a href="/books/NBK557360/figure/ch2.appf.fig11/?report=objectonly" target="object" rid-ob="figobch2appffig11" class="figpopup">Figure 11. Sensitivity analysis excluding studies with a complex attention control: Depression symptoms (see footnotes for scales), ≤6 months</a></p><p id="ch2.appf.fig12"><a href="/books/NBK557360/figure/ch2.appf.fig12/?report=objectonly" target="object" rid-ob="figobch2appffig12" class="figpopup">Figure 12. Depression symptoms (scale: CESD-R), >6 to ≤18 months</a></p><p id="ch2.appf.fig13"><a href="/books/NBK557360/figure/ch2.appf.fig13/?report=objectonly" target="object" rid-ob="figobch2appffig13" class="figpopup">Figure 13. Discontinuation for any reason</a></p><p id="ch2.appf.fig14"><a href="/books/NBK557360/figure/ch2.appf.fig14/?report=objectonly" target="object" rid-ob="figobch2appffig14" class="figpopup">Figure 14. Sensitivity analysis excluding studies with a high risk of bias: Discontinuation for any reason</a></p><p id="ch2.appf.fig15"><a href="/books/NBK557360/figure/ch2.appf.fig15/?report=objectonly" target="object" rid-ob="figobch2appffig15" class="figpopup">Figure 15. Sensitivity analysis excluding studies with a complex attention control: Discontinuation for any reason</a></p></div><div id="ch2.appf.s1.2.4"><h5>Computer CBT vs waiting list/no treatment</h5><p id="ch2.appf.fig16"><a href="/books/NBK557360/figure/ch2.appf.fig16/?report=objectonly" target="object" rid-ob="figobch2appffig16" class="figpopup">Figure 16. Depression symptoms (see footnotes for scales), Post-treatment</a></p></div><div id="ch2.appf.s1.2.5"><h5>Group CBT vs attention control</h5><p id="ch2.appf.fig17"><a href="/books/NBK557360/figure/ch2.appf.fig17/?report=objectonly" target="object" rid-ob="figobch2appffig17" class="figpopup">Figure 17. Depression symptoms (see footnotes for scales), Post-treatment</a></p><p id="ch2.appf.fig18"><a href="/books/NBK557360/figure/ch2.appf.fig18/?report=objectonly" target="object" rid-ob="figobch2appffig18" class="figpopup">Figure 18. Depression symptoms (see footnotes for scales), ≤6 months</a></p><p id="ch2.appf.fig19"><a href="/books/NBK557360/figure/ch2.appf.fig19/?report=objectonly" target="object" rid-ob="figobch2appffig19" class="figpopup">Figure 19. Discontinuation for any reason</a></p></div><div id="ch2.appf.s1.2.6"><h5>Group CBT vs waiting list/no treatment</h5><p id="ch2.appf.fig20"><a href="/books/NBK557360/figure/ch2.appf.fig20/?report=objectonly" target="object" rid-ob="figobch2appffig20" class="figpopup">Figure 20. Depression symptoms (see footnotes for scales), Post-treatment</a></p><p id="ch2.appf.fig21"><a href="/books/NBK557360/figure/ch2.appf.fig21/?report=objectonly" target="object" rid-ob="figobch2appffig21" class="figpopup">Figure 21. Depression symptoms (see footnotes for scales), ≤6 months</a></p><p id="ch2.appf.fig22"><a href="/books/NBK557360/figure/ch2.appf.fig22/?report=objectonly" target="object" rid-ob="figobch2appffig22" class="figpopup">Figure 22. Depression symptoms (see footnotes for scales), >6 months to ≤18 months</a></p><p id="ch2.appf.fig23"><a href="/books/NBK557360/figure/ch2.appf.fig23/?report=objectonly" target="object" rid-ob="figobch2appffig23" class="figpopup">Figure 23. Discontinuation for any reason</a></p></div><div id="ch2.appf.s1.2.7"><h5>Group CBT vs usual care</h5><p id="ch2.appf.fig24"><a href="/books/NBK557360/figure/ch2.appf.fig24/?report=objectonly" target="object" rid-ob="figobch2appffig24" class="figpopup">Figure 24. Functional status (scale: GAF), Post-treatment</a></p><p id="ch2.appf.fig25"><a href="/books/NBK557360/figure/ch2.appf.fig25/?report=objectonly" target="object" rid-ob="figobch2appffig25" class="figpopup">Figure 25. Functional status (scale: GAF), >6 to ≤18 months</a></p><p id="ch2.appf.fig26"><a href="/books/NBK557360/figure/ch2.appf.fig26/?report=objectonly" target="object" rid-ob="figobch2appffig26" class="figpopup">Figure 26. Depression symptoms (see footnotes for scales), Post-treatment</a></p><p id="ch2.appf.fig27"><a href="/books/NBK557360/figure/ch2.appf.fig27/?report=objectonly" target="object" rid-ob="figobch2appffig27" class="figpopup">Figure 27. Depression symptoms (see footnotes for scales), ≤6 months</a></p><p id="ch2.appf.fig28"><a href="/books/NBK557360/figure/ch2.appf.fig28/?report=objectonly" target="object" rid-ob="figobch2appffig28" class="figpopup">Figure 28. Depression symptoms (scale: HAM-D), >6 to ≤18 months</a></p><p id="ch2.appf.fig29"><a href="/books/NBK557360/figure/ch2.appf.fig29/?report=objectonly" target="object" rid-ob="figobch2appffig29" class="figpopup">Figure 29. Discontinuation for any reason</a></p></div><div id="ch2.appf.s1.2.8"><h5>Group CBT vs relaxation</h5><p id="ch2.appf.fig30"><a href="/books/NBK557360/figure/ch2.appf.fig30/?report=objectonly" target="object" rid-ob="figobch2appffig30" class="figpopup">Figure 30. Depression symptoms (see footnote for scales), Post-treatment</a></p><p id="ch2.appf.fig31"><a href="/books/NBK557360/figure/ch2.appf.fig31/?report=objectonly" target="object" rid-ob="figobch2appffig31" class="figpopup">Figure 31. Depression symptoms (see footnote for scales), ≤6 months</a></p></div><div id="ch2.appf.s1.2.9"><h5>Guided self-help vs waiting list/no treatment</h5><p id="ch2.appf.fig32"><a href="/books/NBK557360/figure/ch2.appf.fig32/?report=objectonly" target="object" rid-ob="figobch2appffig32" class="figpopup">Figure 32. Depression symptoms (see footnote for scales), Post-treatment</a></p></div><div id="ch2.appf.s1.2.10"><h5>Group IPT vs group non-directive supportive therapy</h5><p id="ch2.appf.fig33"><a href="/books/NBK557360/figure/ch2.appf.fig33/?report=objectonly" target="object" rid-ob="figobch2appffig33" class="figpopup">Figure 33. Functional status (scale: CGAS), Post-treatment</a></p><p id="ch2.appf.fig34"><a href="/books/NBK557360/figure/ch2.appf.fig34/?report=objectonly" target="object" rid-ob="figobch2appffig34" class="figpopup">Figure 34. Functional status (scale: CGAS), ≤6 months</a></p><p id="ch2.appf.fig35"><a href="/books/NBK557360/figure/ch2.appf.fig35/?report=objectonly" target="object" rid-ob="figobch2appffig35" class="figpopup">Figure 35. Functional status (scale: CGAS), >6 to ≤18 months</a></p><p id="ch2.appf.fig36"><a href="/books/NBK557360/figure/ch2.appf.fig36/?report=objectonly" target="object" rid-ob="figobch2appffig36" class="figpopup">Figure 36. Depression symptoms (see footnotes for scales), Post-treatment</a></p><p id="ch2.appf.fig37"><a href="/books/NBK557360/figure/ch2.appf.fig37/?report=objectonly" target="object" rid-ob="figobch2appffig37" class="figpopup">Figure 37. Depression symptoms (see footnote for scales), ≤6 months</a></p><p id="ch2.appf.fig38"><a href="/books/NBK557360/figure/ch2.appf.fig38/?report=objectonly" target="object" rid-ob="figobch2appffig38" class="figpopup">Figure 38. Depression symptoms (see footnote for scales), >6 to ≤18 months</a></p><p id="ch2.appf.fig39"><a href="/books/NBK557360/figure/ch2.appf.fig39/?report=objectonly" target="object" rid-ob="figobch2appffig39" class="figpopup">Figure 39. Discontinuation for any reason</a></p></div><div id="ch2.appf.s1.2.11"><h5>Relaxation vs waiting list/no treatment</h5><p id="ch2.appf.fig40"><a href="/books/NBK557360/figure/ch2.appf.fig40/?report=objectonly" target="object" rid-ob="figobch2appffig40" class="figpopup">Figure 40. Depression symptoms (see footnote for scales), ≤6 months</a></p></div></div></div><div id="ch2.appf.s2"><h4>Moderate to severe depression</h4><div id="ch2.appf.s2.1"><h5>Age 5–11 years</h5><div id="ch2.appf.s2.1.1"><h5>Group CBT v waiting list/no treatment</h5><p id="ch2.appf.fig41"><a href="/books/NBK557360/figure/ch2.appf.fig41/?report=objectonly" target="object" rid-ob="figobch2appffig41" class="figpopup">Figure 41. Depression symptoms (see footnotes for scales), Post-treatment</a></p></div></div><div id="ch2.appf.s2.2"><h5>Age 12–18 years</h5><div id="ch2.appf.s2.2.1"><h5>Individual CBT vs waiting list/no treatment</h5><p id="ch2.appf.fig42"><a href="/books/NBK557360/figure/ch2.appf.fig42/?report=objectonly" target="object" rid-ob="figobch2appffig42" class="figpopup">Figure 42. Depression symptoms (see footnote for scales), Post-treatment</a></p></div><div id="ch2.appf.s2.2.2"><h5>Individual CBT vs usual care</h5><p id="ch2.appf.fig43"><a href="/books/NBK557360/figure/ch2.appf.fig43/?report=objectonly" target="object" rid-ob="figobch2appffig43" class="figpopup">Figure 43. Depression symptoms (see footnote for scales), Post-treatment</a></p><p id="ch2.appf.fig44"><a href="/books/NBK557360/figure/ch2.appf.fig44/?report=objectonly" target="object" rid-ob="figobch2appffig44" class="figpopup">Figure 44. Sensitivity analysis excluding studies with a high risk of bias: Depression symptoms (see footnotes for scales), Post-treatment</a></p><p id="ch2.appf.fig45"><a href="/books/NBK557360/figure/ch2.appf.fig45/?report=objectonly" target="object" rid-ob="figobch2appffig45" class="figpopup">Figure 45. Discontinuation for any reason</a></p><p id="ch2.appf.fig46"><a href="/books/NBK557360/figure/ch2.appf.fig46/?report=objectonly" target="object" rid-ob="figobch2appffig46" class="figpopup">Figure 46. Sensitivity analysis excluding studies with a high risk of bias: Discontinuation for any reason</a></p></div><div id="ch2.appf.s2.2.3"><h5>Individual CBT vs non-directive supportive therapy</h5><p id="ch2.appf.fig47"><a href="/books/NBK557360/figure/ch2.appf.fig47/?report=objectonly" target="object" rid-ob="figobch2appffig47" class="figpopup">Figure 47. Remission, Post-treatment</a></p><p id="ch2.appf.fig48"><a href="/books/NBK557360/figure/ch2.appf.fig48/?report=objectonly" target="object" rid-ob="figobch2appffig48" class="figpopup">Figure 48. Discontinuation for any reason</a></p></div><div id="ch2.appf.s2.2.4"><h5>Group CBT vs waiting list/no treatment</h5><p id="ch2.appf.fig49"><a href="/books/NBK557360/figure/ch2.appf.fig49/?report=objectonly" target="object" rid-ob="figobch2appffig49" class="figpopup">Figure 49. Depression symptoms, Post-treatment</a></p><p id="ch2.appf.fig50"><a href="/books/NBK557360/figure/ch2.appf.fig50/?report=objectonly" target="object" rid-ob="figobch2appffig50" class="figpopup">Figure 50. Discontinuation for any reason</a></p></div><div id="ch2.appf.s2.2.5"><h5>Group CBT vs group CBT and parent sessions</h5><p id="ch2.appf.fig51"><a href="/books/NBK557360/figure/ch2.appf.fig51/?report=objectonly" target="object" rid-ob="figobch2appffig51" class="figpopup">Figure 51. Depression symptoms (scale : BDI), Post-treatment</a></p><p id="ch2.appf.fig52"><a href="/books/NBK557360/figure/ch2.appf.fig52/?report=objectonly" target="object" rid-ob="figobch2appffig52" class="figpopup">Figure 52. Discontinuation for any reason</a></p></div><div id="ch2.appf.s2.2.6"><h5>Group CBT and parent sessions vs waiting list/no treatment</h5><p id="ch2.appf.fig53"><a href="/books/NBK557360/figure/ch2.appf.fig53/?report=objectonly" target="object" rid-ob="figobch2appffig53" class="figpopup">Figure 53. Depression symptoms (scale : BDI), Post-treatment</a></p><p id="ch2.appf.fig54"><a href="/books/NBK557360/figure/ch2.appf.fig54/?report=objectonly" target="object" rid-ob="figobch2appffig54" class="figpopup">Figure 54. Discontinuation for any reason</a></p></div><div id="ch2.appf.s2.2.7"><h5>Family therapy vs usual care</h5><p id="ch2.appf.fig55"><a href="/books/NBK557360/figure/ch2.appf.fig55/?report=objectonly" target="object" rid-ob="figobch2appffig55" class="figpopup">Figure 55. Depression symptoms (see footnote for scales), Post-treatment</a></p><p id="ch2.appf.fig56"><a href="/books/NBK557360/figure/ch2.appf.fig56/?report=objectonly" target="object" rid-ob="figobch2appffig56" class="figpopup">Figure 56. Depression symptoms (see footnote for scales), Post-treatment</a></p><p id="ch2.appf.fig57"><a href="/books/NBK557360/figure/ch2.appf.fig57/?report=objectonly" target="object" rid-ob="figobch2appffig57" class="figpopup">Figure 57. Discontinuation for any reason</a></p></div></div></div></div><div id="ch2.appg"><h3>Appendix G. Network meta-analysis results</h3><p>RCTs were divided into those which recruited children and young people with depression symptoms (mild depression), and those which recruited children and young people with a depressive disorder diagnosis (moderate to severe depression). NMA results show severity of depression as mild depression or moderate to severe depression.</p><div id="ch2.appg.s1"><h4>Model fit statistics for all outcomes</h4><p id="ch2.appg.tab1"><a href="/books/NBK557360/table/ch2.appg.tab1/?report=objectonly" target="object" rid-ob="figobch2appgtab1" class="figpopup">Table 12. Model fit statistics</a></p></div><div id="ch2.appg.s2"><h4>Mild depression in 12 to 18 year olds</h4><div id="ch2.appg.s2.1"><h5>Depression symptoms, post-treatment on the CDI scale for mild depression in 12 to 18 year olds</h5><div id="ch2.appg.s2.1.1"><h5>Network diagram</h5><p id="ch2.appg.fig1"><a href="/books/NBK557360/figure/ch2.appg.fig1/?report=objectonly" target="object" rid-ob="figobch2appgfig1" class="figpopup">Figure 58. Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s2.1.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig2"><a href="/books/NBK557360/figure/ch2.appg.fig2/?report=objectonly" target="object" rid-ob="figobch2appgfig2" class="figpopup">Figure 59. Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)
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</a></p></div><div id="ch2.appg.s2.1.3"><h5>Rank probability histograms for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds</h5><p id="ch2.appg.fig3"><a href="/books/NBK557360/figure/ch2.appg.fig3/?report=objectonly" target="object" rid-ob="figobch2appgfig3" class="figpopup">Figure 60. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s2.1.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab2"><a href="/books/NBK557360/table/ch2.appg.tab2/?report=objectonly" target="object" rid-ob="figobch2appgtab2" class="figpopup">Table 13. Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s2.2"><h5>Depression symptoms, ≤6 months on the CDI scale for mild depression in 12 to 18 year olds</h5><div id="ch2.appg.s2.2.1"><h5>Network diagram</h5><p id="ch2.appg.fig4"><a href="/books/NBK557360/figure/ch2.appg.fig4/?report=objectonly" target="object" rid-ob="figobch2appgfig4" class="figpopup">Figure 61. Diagram of the network of studies underlying the NMA for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</a></p><div id="ch2.appg.s2.2.1.1"><h5>Caterpillar plot</h5><p id="ch2.appg.fig5"><a href="/books/NBK557360/figure/ch2.appg.fig5/?report=objectonly" target="object" rid-ob="figobch2appgfig5" class="figpopup">Figure 62. Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)</a></p></div></div><div id="ch2.appg.s2.2.2"><h5>Rank probability histograms for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds</h5><p id="ch2.appg.fig6"><a href="/books/NBK557360/figure/ch2.appg.fig6/?report=objectonly" target="object" rid-ob="figobch2appgfig6" class="figpopup">Figure 63. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s2.2.3"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab3"><a href="/books/NBK557360/table/ch2.appg.tab3/?report=objectonly" target="object" rid-ob="figobch2appgtab3" class="figpopup">Table 14. Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s2.3"><h5>Depression symptoms, >6 to ≤18 months on the CDI scale for mild depression in 12 to 18 year olds</h5><div id="ch2.appg.s2.3.1"><h5>Network diagram</h5><p id="ch2.appg.fig7"><a href="/books/NBK557360/figure/ch2.appg.fig7/?report=objectonly" target="object" rid-ob="figobch2appgfig7" class="figpopup">Figure 64. Diagram of the network of studies underlying the NMA for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s2.3.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig8"><a href="/books/NBK557360/figure/ch2.appg.fig8/?report=objectonly" target="object" rid-ob="figobch2appgfig8" class="figpopup">Figure 65. Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s2.3.3"><h5>Rank probability histograms for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds</h5><p id="ch2.appg.fig9"><a href="/books/NBK557360/figure/ch2.appg.fig9/?report=objectonly" target="object" rid-ob="figobch2appgfig9" class="figpopup">Figure 66. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s2.3.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab4"><a href="/books/NBK557360/table/ch2.appg.tab4/?report=objectonly" target="object" rid-ob="figobch2appgtab4" class="figpopup">Table 15. Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, <6 to ≤18 months, in mild depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s2.4"><h5>Remission, post-treatment for mild depression in 12 to 18 year olds</h5><div id="ch2.appg.s2.4.1"><h5>Network diagram</h5><p id="ch2.appg.fig10"><a href="/books/NBK557360/figure/ch2.appg.fig10/?report=objectonly" target="object" rid-ob="figobch2appgfig10" class="figpopup">Figure 67. Diagram of the network of studies underlying the NMA for remission, post-treatment, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</a></p></div><div id="ch2.appg.s2.4.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig11"><a href="/books/NBK557360/figure/ch2.appg.fig11/?report=objectonly" target="object" rid-ob="figobch2appgfig11" class="figpopup">Figure 68. Relative effectiveness of all options versus usual care for remission, post-treatment, in mild depression, 12 to 18 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour usual care; values higher than 1 favour the other treatments.)</a></p></div><div id="ch2.appg.s2.4.3"><h5>Rank probability histograms for remission, post-treatment, in mild depression, 12 to 18 year olds</h5><p id="ch2.appg.fig12"><a href="/books/NBK557360/figure/ch2.appg.fig12/?report=objectonly" target="object" rid-ob="figobch2appgfig12" class="figpopup">Figure 69. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)</a></p></div><div id="ch2.appg.s2.4.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab5"><a href="/books/NBK557360/table/ch2.appg.tab5/?report=objectonly" target="object" rid-ob="figobch2appgtab5" class="figpopup">Table 16. Relative effectiveness of all pairwise combinations for remission, post-treatment, in mild depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs greater than 1 favour the column defining treatment, RRs less than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR greater than 1 favour the row defining treatment. RRs less than 1 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s2.5"><h5>Discontinuation for mild depression in 12 to 18 year olds</h5><div id="ch2.appg.s2.5.1"><h5>Network diagram</h5><p id="ch2.appg.fig13"><a href="/books/NBK557360/figure/ch2.appg.fig13/?report=objectonly" target="object" rid-ob="figobch2appgfig13" class="figpopup">Figure 70. Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s2.5.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig14"><a href="/books/NBK557360/figure/ch2.appg.fig14/?report=objectonly" target="object" rid-ob="figobch2appgfig14" class="figpopup">Figure 71. Relative effectiveness of all options versus waiting list/no treatment for discontinuation, endpoint, in mild depression, 12 to 18 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour waiting list/no treatment; values lower than 1 favour the other treatments.)</a></p></div><div id="ch2.appg.s2.5.3"><h5>Rank probability histograms for discontinuation, endpoint, in mild depression, 12 to 18 year olds</h5><p id="ch2.appg.fig15"><a href="/books/NBK557360/figure/ch2.appg.fig15/?report=objectonly" target="object" rid-ob="figobch2appgfig15" class="figpopup">Figure 72. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s2.5.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab6"><a href="/books/NBK557360/table/ch2.appg.tab6/?report=objectonly" target="object" rid-ob="figobch2appgtab6" class="figpopup">Table 17. Relative effectiveness of all pairwise combinations for discontinuation, endpoint, in mild depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs less than 1 favour the column defining treatment, RRs greater than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR less than 1 favour the row defining treatment. RRs greater than 1 favour the column defining treatment.)</a></p></div></div></div><div id="ch2.appg.s3"><h4>Moderate to severe depression in 5 to 11 year olds</h4><div id="ch2.appg.s3.1"><h5>Depression symptoms, post-treatment on the CDI scale for moderate to severe depression in 5 to 11 year olds</h5><div id="ch2.appg.s3.1.1"><h5>Network diagram</h5><p id="ch2.appg.fig16"><a href="/books/NBK557360/figure/ch2.appg.fig16/?report=objectonly" target="object" rid-ob="figobch2appgfig16" class="figpopup">Figure 73. Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s3.1.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig17"><a href="/books/NBK557360/figure/ch2.appg.fig17/?report=objectonly" target="object" rid-ob="figobch2appgfig17" class="figpopup">Figure 74. Relative effectiveness of all options versus family based IPT on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour family based IPT; values lower than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s3.1.3"><h5>Rank probability histograms for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds</h5><p id="ch2.appg.fig18"><a href="/books/NBK557360/figure/ch2.appg.fig18/?report=objectonly" target="object" rid-ob="figobch2appgfig18" class="figpopup">Figure 75. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s3.1.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab7"><a href="/books/NBK557360/table/ch2.appg.tab7/?report=objectonly" target="object" rid-ob="figobch2appgtab7" class="figpopup">Table 18. Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s3.2"><h5>Functional status, post-treatment on the CGAS scale for moderate to severe depression in 5 to 11 year olds</h5><div id="ch2.appg.s3.2.1"><h5>Network diagram</h5><p id="ch2.appg.fig19"><a href="/books/NBK557360/figure/ch2.appg.fig19/?report=objectonly" target="object" rid-ob="figobch2appgfig19" class="figpopup">Figure 76. Diagram of the network of studies underlying the NMA for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s3.2.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig20"><a href="/books/NBK557360/figure/ch2.appg.fig20/?report=objectonly" target="object" rid-ob="figobch2appgfig20" class="figpopup">Figure 77. Relative effectiveness of all options versus family therapy on the CGAS scale for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour family therapy; values higher than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s3.2.3"><h5>Rank probability histograms for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds</h5><p id="ch2.appg.fig21"><a href="/books/NBK557360/figure/ch2.appg.fig21/?report=objectonly" target="object" rid-ob="figobch2appgfig21" class="figpopup">Figure 78. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)</a></p></div><div id="ch2.appg.s3.2.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab8"><a href="/books/NBK557360/table/ch2.appg.tab8/?report=objectonly" target="object" rid-ob="figobch2appgtab8" class="figpopup">Table 19. Relative effectiveness of all pairwise combinations on the GCAS scale for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs greater than 0 favour the column defining treatment, MDs less than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs greater than 0 favour the row defining treatment. MDs less than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s3.3"><h5>Remission, post-treatment for moderate to severe depression in 5 to 11 year olds</h5><div id="ch2.appg.s3.3.1"><h5>Network diagram</h5><p id="ch2.appg.fig22"><a href="/books/NBK557360/figure/ch2.appg.fig22/?report=objectonly" target="object" rid-ob="figobch2appgfig22" class="figpopup">Figure 79. Diagram of the network of studies underlying the NMA for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s3.3.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig23"><a href="/books/NBK557360/figure/ch2.appg.fig23/?report=objectonly" target="object" rid-ob="figobch2appgfig23" class="figpopup">Figure 80. Relative effectiveness of all options versus family based IPT for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour family based IPT; values higher than 1 favour the other treatments.)</a></p></div><div id="ch2.appg.s3.3.3"><h5>Rank probability histograms for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds</h5><p id="ch2.appg.fig24"><a href="/books/NBK557360/figure/ch2.appg.fig24/?report=objectonly" target="object" rid-ob="figobch2appgfig24" class="figpopup">Figure 81. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 4 is best.)</a></p></div><div id="ch2.appg.s3.3.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab9"><a href="/books/NBK557360/table/ch2.appg.tab9/?report=objectonly" target="object" rid-ob="figobch2appgtab9" class="figpopup">Table 20. Relative effectiveness of all pairwise combinations for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs greater than 1 favour the column defining treatment, RRs less than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR greater than 1 favour the row defining treatment. RRs less than 1 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s3.4"><h5>Discontinuation for moderate to severe depression in 5 to 11 year olds</h5><div id="ch2.appg.s3.4.1"><h5>Network diagram</h5><p id="ch2.appg.fig25"><a href="/books/NBK557360/figure/ch2.appg.fig25/?report=objectonly" target="object" rid-ob="figobch2appgfig25" class="figpopup">Figure 82. Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s3.4.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig26"><a href="/books/NBK557360/figure/ch2.appg.fig26/?report=objectonly" target="object" rid-ob="figobch2appgfig26" class="figpopup">Figure 83. Relative effectiveness of all options versus family based IPT for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour family based IPT; values lower than 1 favour the other treatments.)</a></p></div><div id="ch2.appg.s3.4.3"><h5>Rank probability histograms for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds</h5><p id="ch2.appg.fig27"><a href="/books/NBK557360/figure/ch2.appg.fig27/?report=objectonly" target="object" rid-ob="figobch2appgfig27" class="figpopup">Figure 84. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best</a></p></div><div id="ch2.appg.s3.4.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab10"><a href="/books/NBK557360/table/ch2.appg.tab10/?report=objectonly" target="object" rid-ob="figobch2appgtab10" class="figpopup">Table 21. Relative effectiveness of all pairwise combinations for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs less than 1 favour the column defining treatment, RRs greater than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR less than 1 favour the row defining treatment. RRs greater than 1 favour the column defining treatment.)</a></p></div></div></div><div id="ch2.appg.s4"><h4>Moderate to severe depression in 12 to 18 year olds</h4><div id="ch2.appg.s4.1"><h5>Depression symptoms, post-treatment on the CDI scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.1.1"><h5>Network diagram</h5><p id="ch2.appg.fig28"><a href="/books/NBK557360/figure/ch2.appg.fig28/?report=objectonly" target="object" rid-ob="figobch2appgfig28" class="figpopup">Figure 85. Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s4.1.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig29"><a href="/books/NBK557360/figure/ch2.appg.fig29/?report=objectonly" target="object" rid-ob="figobch2appgfig29" class="figpopup">Figure 86. Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.1.3"><h5>Rank probability histograms for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig30"><a href="/books/NBK557360/figure/ch2.appg.fig30/?report=objectonly" target="object" rid-ob="figobch2appgfig30" class="figpopup">Figure 87. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s4.1.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab11"><a href="/books/NBK557360/table/ch2.appg.tab11/?report=objectonly" target="object" rid-ob="figobch2appgtab11" class="figpopup">Table 22. Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pairwise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.2"><h5>Depression symptoms, ≤6 months on the CDI scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.2.1"><h5>Network diagram</h5><p id="ch2.appg.fig31"><a href="/books/NBK557360/figure/ch2.appg.fig31/?report=objectonly" target="object" rid-ob="figobch2appgfig31" class="figpopup">Figure 88. Diagram of the network of studies underlying the NMA for depression symptoms, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy)</a></p></div><div id="ch2.appg.s4.2.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig32"><a href="/books/NBK557360/figure/ch2.appg.fig32/?report=objectonly" target="object" rid-ob="figobch2appgfig32" class="figpopup">Figure 89. Relative effectiveness of all options versus usual care on the CDI scale for depression symptoms, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.2.3"><h5>Rank probability histograms for depression symptoms, ≤6 months, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig33"><a href="/books/NBK557360/figure/ch2.appg.fig33/?report=objectonly" target="object" rid-ob="figobch2appgfig33" class="figpopup">Figure 90. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s4.2.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab12"><a href="/books/NBK557360/table/ch2.appg.tab12/?report=objectonly" target="object" rid-ob="figobch2appgtab12" class="figpopup">Table 23. Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, .6 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.3"><h5>Depression symptoms, >6 to ≤18 months on the CDI scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.3.1"><h5>Network diagram</h5><p id="ch2.appg.fig34"><a href="/books/NBK557360/figure/ch2.appg.fig34/?report=objectonly" target="object" rid-ob="figobch2appgfig34" class="figpopup">Figure 91. Diagram of the network of studies underlying the NMA for depression symptoms, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</a></p></div><div id="ch2.appg.s4.3.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig35"><a href="/books/NBK557360/figure/ch2.appg.fig35/?report=objectonly" target="object" rid-ob="figobch2appgfig35" class="figpopup">Figure 92. Relative effectiveness of all options versus usual care on the CDI scale for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.3.3"><h5>Rank probability histograms for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds</h5><p id="ch2.appg.fig36"><a href="/books/NBK557360/figure/ch2.appg.fig36/?report=objectonly" target="object" rid-ob="figobch2appgfig36" class="figpopup">Figure 93. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s4.3.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab13"><a href="/books/NBK557360/table/ch2.appg.tab13/?report=objectonly" target="object" rid-ob="figobch2appgtab13" class="figpopup">Table 24. Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, <6 to ≤18 months, in mild depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.4"><h5>Functional status, post-treatment on the CGAS scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.4.1"><h5>Network diagram</h5><p id="ch2.appg.fig37"><a href="/books/NBK557360/figure/ch2.appg.fig37/?report=objectonly" target="object" rid-ob="figobch2appgfig37" class="figpopup">Figure 94. Diagram of the network of studies underlying the NMA for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s4.4.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig38"><a href="/books/NBK557360/figure/ch2.appg.fig38/?report=objectonly" target="object" rid-ob="figobch2appgfig38" class="figpopup">Figure 95. Relative effectiveness of all options versus usual care on the CGAS scale for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour usual care; values higher than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.4.3"><h5>Rank probability histograms for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig39"><a href="/books/NBK557360/figure/ch2.appg.fig39/?report=objectonly" target="object" rid-ob="figobch2appgfig39" class="figpopup">Figure 96. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 13 is best.)</a></p></div><div id="ch2.appg.s4.4.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab14"><a href="/books/NBK557360/table/ch2.appg.tab14/?report=objectonly" target="object" rid-ob="figobch2appgtab14" class="figpopup">Table 25. Relative effectiveness of all pairwise combinations on the CGAS scale for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds.(Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs greater than 0 favour the column defining treatment, MDs less than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs greater than 0 favour the row defining treatment. MDs less than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.5"><h5>Functional status, ≤6 months on the CGAS scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.5.1"><h5>Network diagram</h5><p id="ch2.appg.fig40"><a href="/books/NBK557360/figure/ch2.appg.fig40/?report=objectonly" target="object" rid-ob="figobch2appgfig40" class="figpopup">Figure 97. Diagram of the network of studies underlying the NMA for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</a></p></div><div id="ch2.appg.s4.5.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig41"><a href="/books/NBK557360/figure/ch2.appg.fig41/?report=objectonly" target="object" rid-ob="figobch2appgfig41" class="figpopup">Figure 98. Relative effectiveness of all options versus CBT on the CGAS scale for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour CBT; values higher than 0 favour the other treatments)</a></p></div><div id="ch2.appg.s4.5.3"><h5>Rank probability histograms for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig42"><a href="/books/NBK557360/figure/ch2.appg.fig42/?report=objectonly" target="object" rid-ob="figobch2appgfig42" class="figpopup">Figure 99. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)</a></p></div><div id="ch2.appg.s4.5.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab15"><a href="/books/NBK557360/table/ch2.appg.tab15/?report=objectonly" target="object" rid-ob="figobch2appgtab15" class="figpopup">Table 26. Relative effectiveness of all pairwise combinations on the CGAS scale for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs greater than 0 favour the column defining treatment, MDs less than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs greater than 0 favour the row defining treatment. MDs less than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.6"><h5>Functional status, >6 to ≤18 months on the CGAS scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.6.1"><h5>Network diagram</h5><p id="ch2.appg.fig43"><a href="/books/NBK557360/figure/ch2.appg.fig43/?report=objectonly" target="object" rid-ob="figobch2appgfig43" class="figpopup">Figure 100. Diagram of the network of studies underlying the NMA for functional status, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</a></p></div><div id="ch2.appg.s4.6.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig44"><a href="/books/NBK557360/figure/ch2.appg.fig44/?report=objectonly" target="object" rid-ob="figobch2appgfig44" class="figpopup">Figure 101. Relative effectiveness of all options versus usual care on the CGAS scale for functional status, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour usual care; values higher than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.6.3"><h5>Rank probability histograms for functional status, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig45"><a href="/books/NBK557360/figure/ch2.appg.fig45/?report=objectonly" target="object" rid-ob="figobch2appgfig45" class="figpopup">Figure 102. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)</a></p></div><div id="ch2.appg.s4.6.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab16"><a href="/books/NBK557360/table/ch2.appg.tab16/?report=objectonly" target="object" rid-ob="figobch2appgtab16" class="figpopup">Table 27. Relative effectiveness of all pairwise combinations on the CGAS scale for functional status, <6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs greater than 0 favour the column defining treatment, MDs less than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs greater than 0 favour the row defining treatment. MDs less than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.7"><h5>Remission, post-treatment for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.7.1"><h5>Network diagram</h5><p id="ch2.appg.fig46"><a href="/books/NBK557360/figure/ch2.appg.fig46/?report=objectonly" target="object" rid-ob="figobch2appgfig46" class="figpopup">Figure 103. Diagram of the network of studies underlying the NMA for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s4.7.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig47"><a href="/books/NBK557360/figure/ch2.appg.fig47/?report=objectonly" target="object" rid-ob="figobch2appgfig47" class="figpopup">Figure 104. Relative effectiveness of all options versus usual care for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds.(Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour usual care; values higher than 1 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.7.3"><h5>Rank probability histograms for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig48"><a href="/books/NBK557360/figure/ch2.appg.fig48/?report=objectonly" target="object" rid-ob="figobch2appgfig48" class="figpopup">Figure 105. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 9 is best)</a></p></div><div id="ch2.appg.s4.7.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab17"><a href="/books/NBK557360/table/ch2.appg.tab17/?report=objectonly" target="object" rid-ob="figobch2appgtab17" class="figpopup">Table 28. Relative effectiveness of all pairwise combinations for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs greater than 1 favour the column defining treatment, RRs less than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR greater than 1 favour the row defining treatment. RRs less than 1 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.8"><h5>Quality of life, post-treatment on the HoNOSCA scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.8.1"><h5>Network diagram</h5><p id="ch2.appg.fig49"><a href="/books/NBK557360/figure/ch2.appg.fig49/?report=objectonly" target="object" rid-ob="figobch2appgfig49" class="figpopup">Figure 106. Diagram of the network of studies underlying the NMA for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</a></p></div><div id="ch2.appg.s4.8.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig50"><a href="/books/NBK557360/figure/ch2.appg.fig50/?report=objectonly" target="object" rid-ob="figobch2appgfig50" class="figpopup">Figure 107. Relative effectiveness of all options versus pill placebo on the HoNOSCA scale for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour pill placebo; values lower than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.8.3"><h5>Rank probability histograms for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig51"><a href="/books/NBK557360/figure/ch2.appg.fig51/?report=objectonly" target="object" rid-ob="figobch2appgfig51" class="figpopup">Figure 108. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s4.8.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab18"><a href="/books/NBK557360/table/ch2.appg.tab18/?report=objectonly" target="object" rid-ob="figobch2appgtab18" class="figpopup">Table 29. Relative effectiveness of all pairwise combinations on the HoNOSCA scale for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.9"><h5>Quality of life, ≤6 months on the HoNOSCA scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.9.1"><h5>Network diagram</h5><p id="ch2.appg.fig52"><a href="/books/NBK557360/figure/ch2.appg.fig52/?report=objectonly" target="object" rid-ob="figobch2appgfig52" class="figpopup">Figure 109. Diagram of the network of studies underlying the NMA for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</a></p></div><div id="ch2.appg.s4.9.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig53"><a href="/books/NBK557360/figure/ch2.appg.fig53/?report=objectonly" target="object" rid-ob="figobch2appgfig53" class="figpopup">Figure 110. Relative effectiveness of all options versus usual care on the HoNOSCA scale for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.9.3"><h5>Rank probability histograms for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig54"><a href="/books/NBK557360/figure/ch2.appg.fig54/?report=objectonly" target="object" rid-ob="figobch2appgfig54" class="figpopup">Figure 111. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s4.9.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab19"><a href="/books/NBK557360/table/ch2.appg.tab19/?report=objectonly" target="object" rid-ob="figobch2appgtab19" class="figpopup">Table 30. Relative effectiveness of all pairwise combinations on the HoNOSCA scale for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.10"><h5>Quality of life, >6 to ≤18 months on the HoNOSCA scale for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.10.1"><h5>Network diagram</h5><p id="ch2.appg.fig55"><a href="/books/NBK557360/figure/ch2.appg.fig55/?report=objectonly" target="object" rid-ob="figobch2appgfig55" class="figpopup">Figure 112. Diagram of the network of studies underlying the NMA for quality of life, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</a></p></div><div id="ch2.appg.s4.10.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig56"><a href="/books/NBK557360/figure/ch2.appg.fig56/?report=objectonly" target="object" rid-ob="figobch2appgfig56" class="figpopup">Figure 113. Relative effectiveness of all options versus usual care on the HoNOSCA scale for quality of life, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.10.3"><h5>Rank probability histograms for quality of life, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig57"><a href="/books/NBK557360/figure/ch2.appg.fig57/?report=objectonly" target="object" rid-ob="figobch2appgfig57" class="figpopup">Figure 114. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s4.10.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab20"><a href="/books/NBK557360/table/ch2.appg.tab20/?report=objectonly" target="object" rid-ob="figobch2appgtab20" class="figpopup">Table 31. Relative effectiveness of all pairwise combinations on the HoNOSCA scale for quality of life, <6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.11"><h5>Suicide ideation (dichotomous), post-treatment for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.11.1"><h5>Network diagram</h5><p id="ch2.appg.fig58"><a href="/books/NBK557360/figure/ch2.appg.fig58/?report=objectonly" target="object" rid-ob="figobch2appgfig58" class="figpopup">Figure 115. Diagram of the network of studies underlying the NMA for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; NDST: non-directive supportive therapy)</a></p></div><div id="ch2.appg.s4.11.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig59"><a href="/books/NBK557360/figure/ch2.appg.fig59/?report=objectonly" target="object" rid-ob="figobch2appgfig59" class="figpopup">Figure 116. Relative effectiveness of all options versus usual care for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values higher than 1 favour usual care; values lower than 1 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.11.3"><h5>Rank probability histograms for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig60"><a href="/books/NBK557360/figure/ch2.appg.fig60/?report=objectonly" target="object" rid-ob="figobch2appgfig60" class="figpopup">Figure 117. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s4.11.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab21"><a href="/books/NBK557360/table/ch2.appg.tab21/?report=objectonly" target="object" rid-ob="figobch2appgtab21" class="figpopup">Table 32. Relative effectiveness of all pairwise combinations for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs less than 1 favour the column defining treatment, RRs greater than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR less than 1 favour the row defining treatment. RRs greater than 1 favour the column defining treatment.)</a></p></div></div><div id="ch2.appg.s4.12"><h5>Discontinuation for moderate to severe depression in 12 to 18 year olds</h5><div id="ch2.appg.s4.12.1"><h5>Network diagram</h5><p id="ch2.appg.fig61"><a href="/books/NBK557360/figure/ch2.appg.fig61/?report=objectonly" target="object" rid-ob="figobch2appgfig61" class="figpopup">Figure 118. Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy; IPT: interpersonal psychotherapy)</a></p></div><div id="ch2.appg.s4.12.2"><h5>Caterpillar plot</h5><p id="ch2.appg.fig62"><a href="/books/NBK557360/figure/ch2.appg.fig62/?report=objectonly" target="object" rid-ob="figobch2appgfig62" class="figpopup">Figure 119. Relative effectiveness of all options versus waiting list/no treatment for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour waiting list/no treatment; values lower than 1 favour the other treatments.)</a></p></div><div id="ch2.appg.s4.12.3"><h5>Rank probability histograms for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds</h5><p id="ch2.appg.fig63"><a href="/books/NBK557360/figure/ch2.appg.fig63/?report=objectonly" target="object" rid-ob="figobch2appgfig63" class="figpopup">Figure 120. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</a></p></div><div id="ch2.appg.s4.12.4"><h5>Relative effectiveness chart</h5><p id="ch2.appg.tab22"><a href="/books/NBK557360/table/ch2.appg.tab22/?report=objectonly" target="object" rid-ob="figobch2appgtab22" class="figpopup">Table 33. Relative effectiveness of all pairwise combinations for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs less than 1 favour the column defining treatment, RRs greater than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR less than 1 favour the row defining treatment. RRs greater than 1 favour the column defining treatment.)</a></p></div></div></div><div id="ch2.appg.s5"><h4>NMA Summaries</h4><p>Note: tables/graphs in this section are best viewed in colour. Colour formatting was added to help the reader to make sense of the large amount of data contained within each table/graph. Numbers in white bold text are where the 95% credible interval does not cross the line of no effect.</p><p>The results of the NMAs for depressive symptoms post treatment were chosen to be displayed in this way because these NMAs were populated by the largest amount of studies and included the most statistically significant results.</p><div id="ch2.appg.s5.1"><h5>Pairwise probability more effective</h5><p id="ch2.appg.tab23"><a href="/books/NBK557360/table/ch2.appg.tab23/?report=objectonly" target="object" rid-ob="figobch2appgtab23" class="figpopup">Table 34. Age 12–18, Mild, Depressive Symptoms Post Treatment (pairwise probability more effective)</a></p><p>Each cell in <a class="figpopup" href="/books/NBK557360/table/ch2.appg.tab23/?report=objectonly" target="object" rid-figpopup="figch2appgtab23" rid-ob="figobch2appgtab23">Table 34</a> shows the probability that the intervention in the column is more effective than the intervention in the row as calculated from the CODA outputs of the NMA. Values of 0.975 or more (in white) are analogous to a statistically significant result at a 95% confidence interval.</p><p>Columns with more high values (highlighted green rather than red) indicate that the intervention in that column is more likely to be more effective than a larger number of interventions. Row number 1 shows the probability that the intervention is better than waiting list/no treatment.</p><p id="ch2.appg.tab24"><a href="/books/NBK557360/table/ch2.appg.tab24/?report=objectonly" target="object" rid-ob="figobch2appgtab24" class="figpopup">Table 35. Age 12–18, Severe. Depressive Symptoms Post Treatment (pairwise probability more effective)</a></p><p>Each cell in <a class="figpopup" href="/books/NBK557360/table/ch2.appg.tab24/?report=objectonly" target="object" rid-figpopup="figch2appgtab24" rid-ob="figobch2appgtab24">Table 35</a> shows the probability that the intervention in the column is more effective than the intervention in the row as calculated from the CODA outputs of the NMA. Values of 0.975 or more (in white) are analogous to a statistically significant result at a 95% confidence interval. Columns with more high values (highlighted green rather than red) indicate that the intervention in that column is more likely to be more effective than a larger number of interventions. Row number 1 shows the probability that the intervention is better than waiting list/no treatment.</p><p id="ch2.appg.tab25"><a href="/books/NBK557360/table/ch2.appg.tab25/?report=objectonly" target="object" rid-ob="figobch2appgtab25" class="figpopup">Table 36. Age 5–11, Severe. Depressive Symptoms Post Treatment (pairwise probability more effective)</a></p><p>Each cell in <a class="figpopup" href="/books/NBK557360/table/ch2.appg.tab25/?report=objectonly" target="object" rid-figpopup="figch2appgtab25" rid-ob="figobch2appgtab25">Table 36</a> shows the probability that the intervention in the column is more effective than the intervention in the row as calculated from the CODA outputs of the NMA. Values of 0.975 or more (in white) are analogous to a statistically significant result at a 95% confidence interval. Columns with more high values (highlighted green rather than red) indicate that the intervention in that column is more likely to be more effective than a larger number of interventions. Row number 1 shows the probability that the intervention is better than waiting list/no treatment.</p></div><div id="ch2.appg.s5.2"><h5>Ranking summaries for all outcomes</h5><p>The graphs in this section show the probability that each intervention is ranked in each position from best to worst in the NMA for that outcome (the row indicates the outcome in question) and need to be viewed in colour. Note that there are a different number of interventions included in the NMA for each outcome and therefore a different number of total ranks. Unfortunately, due to the number of interventions the results for a single outcome in both 12–18 age groups appear on multiple lines. For example, in the Age 12–18 Mild group there is a ~100% probability that for the NMA of remission post-treatment, usual care was ranked number 3 out of the 3 options (CBT, family therapy and usual care). CBT and family therapy have a roughly 70% and 30% probability of taking rank 1, indicating that there was no significant difference between them but a probability close to 100% that they were better than usual care. In general, the more interventions there are within an NMA, the less likely high probabilities of an intervention holding a particular rank are. For example, for the outcome of depressive symptoms post-treatment in the mild 12–18 group, no intervention holds more than a 50% probability of occupying one of the 15 ranks with the exception of waiting list, which has a 63% probability of being the worst. The reader can interpret the general spread and position of the blocks of colour as indicating the average ranks and their associated uncertainty among other interventions for each NMA although should be careful not to interpret the differences in shading between different outcomes, only within them. These plots were produced to help the committee make sense of the very large number of outcomes and interventions and the strengths and limitations of these plots were discussed at the meeting.</p><div id="ch2.appg.s5.2.1"><h5>Age 12–18, Mild</h5><div id="ch2.appg.fig64" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appgf63&p=BOOKS&id=557360_ch2appgf63.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK557360/bin/ch2appgf63.jpg" alt="Image ch2appgf63" class="tileshop" title="Click on image to zoom" /></a></div></div></div><div id="ch2.appg.s5.2.2"><h5>Age 12–18, Severe</h5><div id="ch2.appg.fig65" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appgf64&p=BOOKS&id=557360_ch2appgf64.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK557360/bin/ch2appgf64.jpg" alt="Image ch2appgf64" class="tileshop" title="Click on image to zoom" /></a></div></div></div><div id="ch2.appg.s5.2.3"><h5>Age 5–11, Severe</h5><div id="ch2.appg.fig66" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appgf65&p=BOOKS&id=557360_ch2appgf65.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK557360/bin/ch2appgf65.jpg" alt="Image ch2appgf65" class="tileshop" title="Click on image to zoom" /></a></div></div></div></div></div></div><div id="ch2.apph"><h3>Appendix H. GRADE tables</h3><div id="ch2.apph.s1"><h4>Pair-wise meta-analysis</h4><p>RCTs were divided into those which recruited children and young people with depression symptoms (mild depression), or those which recruited children and young people with a depressive disorder diagnosis (moderate to severe depression). GRADE tables show severity of depression based on these criteria</p><div id="ch2.apph.s1.1"><h5>Mild depression in 5–11 year olds</h5><div id="ch2.apph.s1.1.1"><h5>Group CBT vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab1"><a href="/books/NBK557360/table/ch2.apph.tab1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab1" rid-ob="figobch2apphtab1"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab1/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab1"><a href="/books/NBK557360/table/ch2.apph.tab1/?report=objectonly" target="object" rid-ob="figobch2apphtab1">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.95 (−1.59, −0.32)</p></div></div></div></div><div id="ch2.apph.s1.2"><h5>Mild depression in 12–18 year olds</h5><div id="ch2.apph.s1.2.1"><h5>Individual CBT vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab2"><a href="/books/NBK557360/table/ch2.apph.tab2/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab2" rid-ob="figobch2apphtab2"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab2/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab2/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab2"><a href="/books/NBK557360/table/ch2.apph.tab2/?report=objectonly" target="object" rid-ob="figobch2apphtab2">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.52 (−1.81, 0.77)</p></div></div><div id="ch2.apph.s1.2.1.1"><h5>Sensitivity analysis excluding studies with a high risk of bias: individual CBT vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab3"><a href="/books/NBK557360/table/ch2.apph.tab3/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab3" rid-ob="figobch2apphtab3"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab3/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab3/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab3"><a href="/books/NBK557360/table/ch2.apph.tab3/?report=objectonly" target="object" rid-ob="figobch2apphtab3">Table</a></h4><p class="float-caption no_bottom_margin">SMD −1.15 (−1.82, −0.48)</p></div></div></div></div></div><div id="ch2.apph.s1.3"><h5>Individual CBT vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab4"><a href="/books/NBK557360/table/ch2.apph.tab4/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab4" rid-ob="figobch2apphtab4"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab4/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab4/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab4"><a href="/books/NBK557360/table/ch2.apph.tab4/?report=objectonly" target="object" rid-ob="figobch2apphtab4">Table</a></h4><p class="float-caption no_bottom_margin">MD 6.90 (1.89, 11.91)</p></div></div><div id="ch2.apph.s1.3.1"><h5>Sensitivity analysis excluding studies with a high risk of bias: individual CBT vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab5"><a href="/books/NBK557360/table/ch2.apph.tab5/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab5" rid-ob="figobch2apphtab5"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab5/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab5/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab5"><a href="/books/NBK557360/table/ch2.apph.tab5/?report=objectonly" target="object" rid-ob="figobch2apphtab5">Table</a></h4><p class="float-caption no_bottom_margin">MD 0.50 (−7.92, 8.92)</p></div></div><div id="ch2.apph.s1.3.1.1"><h5>Individual CBT vs non-directive supportive therapy (NDST)</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab6"><a href="/books/NBK557360/table/ch2.apph.tab6/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab6" rid-ob="figobch2apphtab6"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab6/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab6/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab6"><a href="/books/NBK557360/table/ch2.apph.tab6/?report=objectonly" target="object" rid-ob="figobch2apphtab6">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.46 (−0.82, −0.10)</p></div></div></div><div id="ch2.apph.s1.3.1.2"><h5>Individual CBT and family education vs waiting list</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab7"><a href="/books/NBK557360/table/ch2.apph.tab7/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab7" rid-ob="figobch2apphtab7"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab7/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab7/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab7"><a href="/books/NBK557360/table/ch2.apph.tab7/?report=objectonly" target="object" rid-ob="figobch2apphtab7">Table</a></h4><p class="float-caption no_bottom_margin">MD −2.79 (−10.21, 4.63)</p></div></div></div><div id="ch2.apph.s1.3.1.3"><h5>Computer CBT vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab8"><a href="/books/NBK557360/table/ch2.apph.tab8/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab8" rid-ob="figobch2apphtab8"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab8/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab8/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab8"><a href="/books/NBK557360/table/ch2.apph.tab8/?report=objectonly" target="object" rid-ob="figobch2apphtab8">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.47 (−1.01, 0.07)</p></div></div></div></div><div id="ch2.apph.s1.3.2"><h5>Sensitivity analysis excluding studies with a high risk of bias: computer CBT vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab9"><a href="/books/NBK557360/table/ch2.apph.tab9/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab9" rid-ob="figobch2apphtab9"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab9/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab9/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab9"><a href="/books/NBK557360/table/ch2.apph.tab9/?report=objectonly" target="object" rid-ob="figobch2apphtab9">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.17 (−0.50, 0.17)</p></div></div></div><div id="ch2.apph.s1.3.3"><h5>Sensitivity analysis excluding studies with a complex attention control: computer CBT vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab10"><a href="/books/NBK557360/table/ch2.apph.tab10/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab10" rid-ob="figobch2apphtab10"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab10/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab10/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab10"><a href="/books/NBK557360/table/ch2.apph.tab10/?report=objectonly" target="object" rid-ob="figobch2apphtab10">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.11 (−0.49, 0.28)</p></div></div></div></div><div id="ch2.apph.s1.4"><h5>Computer CBT vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab11"><a href="/books/NBK557360/table/ch2.apph.tab11/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab11" rid-ob="figobch2apphtab11"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab11/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab11/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab11"><a href="/books/NBK557360/table/ch2.apph.tab11/?report=objectonly" target="object" rid-ob="figobch2apphtab11">Table</a></h4><p class="float-caption no_bottom_margin">SMD −1.03 (−1.39, −0.68)</p></div></div><div id="ch2.apph.s1.4.1"><h5>Computer CBT vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab12"><a href="/books/NBK557360/table/ch2.apph.tab12/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab12" rid-ob="figobch2apphtab12"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab12/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab12/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab12"><a href="/books/NBK557360/table/ch2.apph.tab12/?report=objectonly" target="object" rid-ob="figobch2apphtab12">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.16 (−0.45, 0.12)</p></div></div></div><div id="ch2.apph.s1.4.2"><h5>Computer CBT vs group CBT and computer CBT</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab13"><a href="/books/NBK557360/table/ch2.apph.tab13/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab13" rid-ob="figobch2apphtab13"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab13/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab13/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab13"><a href="/books/NBK557360/table/ch2.apph.tab13/?report=objectonly" target="object" rid-ob="figobch2apphtab13">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.09 (−0.47, 0.29)</p></div></div></div><div id="ch2.apph.s1.4.3"><h5>Group CBT vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab14"><a href="/books/NBK557360/table/ch2.apph.tab14/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab14" rid-ob="figobch2apphtab14"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab14/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab14/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab14"><a href="/books/NBK557360/table/ch2.apph.tab14/?report=objectonly" target="object" rid-ob="figobch2apphtab14">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.02 (−0.11, 0.16)</p></div></div></div><div id="ch2.apph.s1.4.4"><h5>Group CBT vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab15"><a href="/books/NBK557360/table/ch2.apph.tab15/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab15" rid-ob="figobch2apphtab15"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab15/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab15/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab15"><a href="/books/NBK557360/table/ch2.apph.tab15/?report=objectonly" target="object" rid-ob="figobch2apphtab15">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.68 (−0.89, −0.48)</p></div></div></div><div id="ch2.apph.s1.4.5"><h5>Group CBT vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab16"><a href="/books/NBK557360/table/ch2.apph.tab16/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab16" rid-ob="figobch2apphtab16"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab16/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab16/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab16"><a href="/books/NBK557360/table/ch2.apph.tab16/?report=objectonly" target="object" rid-ob="figobch2apphtab16">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.27 (−0.00, 0.55)</p></div></div></div><div id="ch2.apph.s1.4.6"><h5>Group CBT vs guided self-help</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab17"><a href="/books/NBK557360/table/ch2.apph.tab17/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab17" rid-ob="figobch2apphtab17"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab17/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab17/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab17"><a href="/books/NBK557360/table/ch2.apph.tab17/?report=objectonly" target="object" rid-ob="figobch2apphtab17">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.58 (−0.89, −0.27)</p></div></div></div><div id="ch2.apph.s1.4.7"><h5>Group CBT vs group non-directive supportive therapy (group NDST)</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab18"><a href="/books/NBK557360/table/ch2.apph.tab18/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab18" rid-ob="figobch2apphtab18"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab18/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab18/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab18"><a href="/books/NBK557360/table/ch2.apph.tab18/?report=objectonly" target="object" rid-ob="figobch2apphtab18">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.36 (−0.66, −0.07)</p></div></div></div><div id="ch2.apph.s1.4.8"><h5>Group CBT vs relaxation</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab19"><a href="/books/NBK557360/table/ch2.apph.tab19/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab19" rid-ob="figobch2apphtab19"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab19/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab19/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab19"><a href="/books/NBK557360/table/ch2.apph.tab19/?report=objectonly" target="object" rid-ob="figobch2apphtab19">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.20 (−0.78, 0.38)</p></div></div></div><div id="ch2.apph.s1.4.9"><h5>Group CBT vs self-modelling</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab20"><a href="/books/NBK557360/table/ch2.apph.tab20/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab20" rid-ob="figobch2apphtab20"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab20/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab20/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab20"><a href="/books/NBK557360/table/ch2.apph.tab20/?report=objectonly" target="object" rid-ob="figobch2apphtab20">Table</a></h4><p class="float-caption no_bottom_margin">MD −6.06 (−35.64, 23.52)</p></div></div></div><div id="ch2.apph.s1.4.10"><h5>Group CBT vs computer CBT</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab21"><a href="/books/NBK557360/table/ch2.apph.tab21/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab21" rid-ob="figobch2apphtab21"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab21/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab21/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab21"><a href="/books/NBK557360/table/ch2.apph.tab21/?report=objectonly" target="object" rid-ob="figobch2apphtab21">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.34 (−0.06, 0.73)</p></div></div></div><div id="ch2.apph.s1.4.11"><h5>Group CBT vs group CBT and computer CBT</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab22"><a href="/books/NBK557360/table/ch2.apph.tab22/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab22" rid-ob="figobch2apphtab22"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab22/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab22/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab22"><a href="/books/NBK557360/table/ch2.apph.tab22/?report=objectonly" target="object" rid-ob="figobch2apphtab22">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.20 (−0.19, 0.58)</p></div></div></div><div id="ch2.apph.s1.4.12"><h5>Group CBT vs group mindfulness</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab23"><a href="/books/NBK557360/table/ch2.apph.tab23/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab23" rid-ob="figobch2apphtab23"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab23/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab23/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab23"><a href="/books/NBK557360/table/ch2.apph.tab23/?report=objectonly" target="object" rid-ob="figobch2apphtab23">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.80 (0.09, 1.51)</p></div></div></div><div id="ch2.apph.s1.4.13"><h5>Group CBT and computer CBT vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab24"><a href="/books/NBK557360/table/ch2.apph.tab24/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab24" rid-ob="figobch2apphtab24"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab24/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab24/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab24"><a href="/books/NBK557360/table/ch2.apph.tab24/?report=objectonly" target="object" rid-ob="figobch2apphtab24">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.00 (−0.38, 0.38)</p></div></div></div><div id="ch2.apph.s1.4.14"><h5>Family therapy vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab25"><a href="/books/NBK557360/table/ch2.apph.tab25/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab25" rid-ob="figobch2apphtab25"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab25/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab25/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab25"><a href="/books/NBK557360/table/ch2.apph.tab25/?report=objectonly" target="object" rid-ob="figobch2apphtab25">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.45 (−0.94, 0.04)</p></div></div></div><div id="ch2.apph.s1.4.15"><h5>Guided self-help vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab26"><a href="/books/NBK557360/table/ch2.apph.tab26/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab26" rid-ob="figobch2apphtab26"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab26/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab26/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab26"><a href="/books/NBK557360/table/ch2.apph.tab26/?report=objectonly" target="object" rid-ob="figobch2apphtab26">Table</a></h4><p class="float-caption no_bottom_margin">MD −8.80 (−15.02, −2.58)</p></div></div></div><div id="ch2.apph.s1.4.16"><h5>Guided self-help vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab27"><a href="/books/NBK557360/table/ch2.apph.tab27/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab27" rid-ob="figobch2apphtab27"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab27/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab27/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab27"><a href="/books/NBK557360/table/ch2.apph.tab27/?report=objectonly" target="object" rid-ob="figobch2apphtab27">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.85 (−2.37, 0.68)</p></div></div></div><div id="ch2.apph.s1.4.17"><h5>Group IPT vs waiting list</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab28"><a href="/books/NBK557360/table/ch2.apph.tab28/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab28" rid-ob="figobch2apphtab28"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab28/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab28/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab28"><a href="/books/NBK557360/table/ch2.apph.tab28/?report=objectonly" target="object" rid-ob="figobch2apphtab28">Table</a></h4><p class="float-caption no_bottom_margin">RR 0.50 (0.21, 1.18)</p></div></div></div><div id="ch2.apph.s1.4.18"><h5>Group IPT vs creative play therapy</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab29"><a href="/books/NBK557360/table/ch2.apph.tab29/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab29" rid-ob="figobch2apphtab29"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab29/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab29/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab29"><a href="/books/NBK557360/table/ch2.apph.tab29/?report=objectonly" target="object" rid-ob="figobch2apphtab29">Table</a></h4><p class="float-caption no_bottom_margin">RR 0.64 (0.26, 1.58)</p></div></div></div><div id="ch2.apph.s1.4.19"><h5>Creative play therapy vs waiting list</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab30"><a href="/books/NBK557360/table/ch2.apph.tab30/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab30" rid-ob="figobch2apphtab30"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab30/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab30/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab30"><a href="/books/NBK557360/table/ch2.apph.tab30/?report=objectonly" target="object" rid-ob="figobch2apphtab30">Table</a></h4><p class="float-caption no_bottom_margin">RR 0.78 (0.37, 1.63)</p></div></div></div><div id="ch2.apph.s1.4.20"><h5>Group IPT vs group non-directive supportive therapy (group NDST)</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab31"><a href="/books/NBK557360/table/ch2.apph.tab31/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab31" rid-ob="figobch2apphtab31"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab31/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab31/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab31"><a href="/books/NBK557360/table/ch2.apph.tab31/?report=objectonly" target="object" rid-ob="figobch2apphtab31">Table</a></h4><p class="float-caption no_bottom_margin">MD 1.44 (−2.31, 5.18)</p></div></div></div><div id="ch2.apph.s1.4.21"><h5>Group non-directive supportive therapy vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab32"><a href="/books/NBK557360/table/ch2.apph.tab32/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab32" rid-ob="figobch2apphtab32"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab32/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab32/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab32"><a href="/books/NBK557360/table/ch2.apph.tab32/?report=objectonly" target="object" rid-ob="figobch2apphtab32">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.27 (−0.57, 0.03)</p></div></div></div><div id="ch2.apph.s1.4.22"><h5>Group non-directive supportive therapy vs guided self-help</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab33"><a href="/books/NBK557360/table/ch2.apph.tab33/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab33" rid-ob="figobch2apphtab33"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab33/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab33/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab33"><a href="/books/NBK557360/table/ch2.apph.tab33/?report=objectonly" target="object" rid-ob="figobch2apphtab33">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.17 (−0.48, 0.13)</p></div></div></div><div id="ch2.apph.s1.4.23"><h5>Relaxation vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab34"><a href="/books/NBK557360/table/ch2.apph.tab34/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab34" rid-ob="figobch2apphtab34"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab34/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab34/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab34"><a href="/books/NBK557360/table/ch2.apph.tab34/?report=objectonly" target="object" rid-ob="figobch2apphtab34">Table</a></h4><p class="float-caption no_bottom_margin">SMD −1.64 (−2.75, −0.53)</p></div></div></div><div id="ch2.apph.s1.4.24"><h5>Relaxation vs self-modelling</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab35"><a href="/books/NBK557360/table/ch2.apph.tab35/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab35" rid-ob="figobch2apphtab35"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab35/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab35/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab35"><a href="/books/NBK557360/table/ch2.apph.tab35/?report=objectonly" target="object" rid-ob="figobch2apphtab35">Table</a></h4><p class="float-caption no_bottom_margin">MD −2.43 (−10.23, 5.37)</p></div></div></div><div id="ch2.apph.s1.4.25"><h5>Self-modelling vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab36"><a href="/books/NBK557360/table/ch2.apph.tab36/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab36" rid-ob="figobch2apphtab36"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab36/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab36/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab36"><a href="/books/NBK557360/table/ch2.apph.tab36/?report=objectonly" target="object" rid-ob="figobch2apphtab36">Table</a></h4><p class="float-caption no_bottom_margin">MD −6.24 (−16.99, 4.51)</p></div></div></div><div id="ch2.apph.s1.4.26"><h5>Dance therapy vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab37"><a href="/books/NBK557360/table/ch2.apph.tab37/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab37" rid-ob="figobch2apphtab37"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab37/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab37/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab37"><a href="/books/NBK557360/table/ch2.apph.tab37/?report=objectonly" target="object" rid-ob="figobch2apphtab37">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.87 (−1.52, −0.22)</p></div></div></div></div><div id="ch2.apph.s1.5"><h5>Moderate to severe depression in 5–11 year olds</h5><div id="ch2.apph.s1.5.1"><h5>Individual CBT vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab38"><a href="/books/NBK557360/table/ch2.apph.tab38/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab38" rid-ob="figobch2apphtab38"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab38/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab38/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab38"><a href="/books/NBK557360/table/ch2.apph.tab38/?report=objectonly" target="object" rid-ob="figobch2apphtab38">Table</a></h4><p class="float-caption no_bottom_margin">MD −0.06 (−4.71, 4.59)</p></div></div></div><div id="ch2.apph.s1.5.2"><h5>Group CBT vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab39"><a href="/books/NBK557360/table/ch2.apph.tab39/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab39" rid-ob="figobch2apphtab39"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab39/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab39/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab39"><a href="/books/NBK557360/table/ch2.apph.tab39/?report=objectonly" target="object" rid-ob="figobch2apphtab39">Table</a></h4><p class="float-caption no_bottom_margin">MD −3.55 (−8.69, 1.59)</p></div></div></div><div id="ch2.apph.s1.5.3"><h5>Group CBT vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab40"><a href="/books/NBK557360/table/ch2.apph.tab40/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab40" rid-ob="figobch2apphtab40"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab40/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab40/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab40"><a href="/books/NBK557360/table/ch2.apph.tab40/?report=objectonly" target="object" rid-ob="figobch2apphtab40">Table</a></h4><p class="float-caption no_bottom_margin">MD −2.75 (−7.81, 2.31)</p></div></div></div><div id="ch2.apph.s1.5.4"><h5>Family psychoeducation with CBT vs pill placebo</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab41"><a href="/books/NBK557360/table/ch2.apph.tab41/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab41" rid-ob="figobch2apphtab41"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab41/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab41/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab41"><a href="/books/NBK557360/table/ch2.apph.tab41/?report=objectonly" target="object" rid-ob="figobch2apphtab41">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.09 (−0.55, 0.74)</p></div></div></div><div id="ch2.apph.s1.5.5"><h5>Family therapy vs non directive supportive therapy (NDST)</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab42"><a href="/books/NBK557360/table/ch2.apph.tab42/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab42" rid-ob="figobch2apphtab42"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab42/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab42/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab42"><a href="/books/NBK557360/table/ch2.apph.tab42/?report=objectonly" target="object" rid-ob="figobch2apphtab42">Table</a></h4><p class="float-caption no_bottom_margin">MD −0.14 (−3.14, 2.86)</p></div></div></div><div id="ch2.apph.s1.5.6"><h5>Family based IPT vs non directive supportive therapy</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab43"><a href="/books/NBK557360/table/ch2.apph.tab43/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab43" rid-ob="figobch2apphtab43"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab43/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab43/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab43"><a href="/books/NBK557360/table/ch2.apph.tab43/?report=objectonly" target="object" rid-ob="figobch2apphtab43">Table</a></h4><p class="float-caption no_bottom_margin">MD −4.90 (−10.76, 0.96)</p></div></div></div><div id="ch2.apph.s1.5.7"><h5>Psychodynamic psychotherapy vs family therapy</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab44"><a href="/books/NBK557360/table/ch2.apph.tab44/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab44" rid-ob="figobch2apphtab44"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab44/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab44/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab44"><a href="/books/NBK557360/table/ch2.apph.tab44/?report=objectonly" target="object" rid-ob="figobch2apphtab44">Table</a></h4><p class="float-caption no_bottom_margin">MD −0.92 (−5.15, 3.31)</p></div></div></div></div><div id="ch2.apph.s1.6"><h5>Moderate to severe depression in 12–18 year olds</h5><div id="ch2.apph.s1.6.1"><h5>Individual CBT vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab45"><a href="/books/NBK557360/table/ch2.apph.tab45/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab45" rid-ob="figobch2apphtab45"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab45/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab45/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab45"><a href="/books/NBK557360/table/ch2.apph.tab45/?report=objectonly" target="object" rid-ob="figobch2apphtab45">Table</a></h4><p class="float-caption no_bottom_margin">SMD −1.77 (−3.13, −0.41)</p></div></div></div><div id="ch2.apph.s1.6.2"><h5>Individual CBT vs pill placebo</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab46"><a href="/books/NBK557360/table/ch2.apph.tab46/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab46" rid-ob="figobch2apphtab46"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab46/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab46/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab46"><a href="/books/NBK557360/table/ch2.apph.tab46/?report=objectonly" target="object" rid-ob="figobch2apphtab46">Table</a></h4><p class="float-caption no_bottom_margin">MD −0.20 (−2.98, 2.58)</p></div></div></div><div id="ch2.apph.s1.6.3"><h5>Individual CBT vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab47"><a href="/books/NBK557360/table/ch2.apph.tab47/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab47" rid-ob="figobch2apphtab47"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab47/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab47/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab47"><a href="/books/NBK557360/table/ch2.apph.tab47/?report=objectonly" target="object" rid-ob="figobch2apphtab47">Table</a></h4><p class="float-caption no_bottom_margin">MD 4.27 (1.99, 6.55)</p></div></div><div id="ch2.apph.s1.6.3.1"><h5>Sensitivity analysis excluding studies with a high risk of bias: individual CBT vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab48"><a href="/books/NBK557360/table/ch2.apph.tab48/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab48" rid-ob="figobch2apphtab48"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab48/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab48/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab48"><a href="/books/NBK557360/table/ch2.apph.tab48/?report=objectonly" target="object" rid-ob="figobch2apphtab48">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.11 (−0.92, 0.69)</p></div></div></div></div><div id="ch2.apph.s1.6.4"><h5>Individual CBT vs family therapy</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab49"><a href="/books/NBK557360/table/ch2.apph.tab49/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab49" rid-ob="figobch2apphtab49"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab49/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab49/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab49"><a href="/books/NBK557360/table/ch2.apph.tab49/?report=objectonly" target="object" rid-ob="figobch2apphtab49">Table</a></h4><p class="float-caption no_bottom_margin">MD −2.40 (−6.61, 1.81)</p></div></div></div><div id="ch2.apph.s1.6.5"><h5>Individual CBT vs non-directive supportive therapy (NDST)</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab50"><a href="/books/NBK557360/table/ch2.apph.tab50/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab50" rid-ob="figobch2apphtab50"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab50/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab50/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab50"><a href="/books/NBK557360/table/ch2.apph.tab50/?report=objectonly" target="object" rid-ob="figobch2apphtab50">Table</a></h4><p class="float-caption no_bottom_margin">MD 0.40 (−4.85, 4.05)</p></div></div></div><div id="ch2.apph.s1.6.6"><h5>Individual CBT vs psychodynamic psychotherapy</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab51"><a href="/books/NBK557360/table/ch2.apph.tab51/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab51" rid-ob="figobch2apphtab51"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab51/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab51/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab51"><a href="/books/NBK557360/table/ch2.apph.tab51/?report=objectonly" target="object" rid-ob="figobch2apphtab51">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.23 (−0.50, 0.04)</p></div></div></div><div id="ch2.apph.s1.6.7"><h5>Individual CBT vs psychosocial intervention</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab52"><a href="/books/NBK557360/table/ch2.apph.tab52/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab52" rid-ob="figobch2apphtab52"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab52/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab52/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab52"><a href="/books/NBK557360/table/ch2.apph.tab52/?report=objectonly" target="object" rid-ob="figobch2apphtab52">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.46 (−0.73, −0.18)</p></div></div></div><div id="ch2.apph.s1.6.8"><h5>Individual CBT vs relaxation</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab53"><a href="/books/NBK557360/table/ch2.apph.tab53/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab53" rid-ob="figobch2apphtab53"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab53/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab53/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab53"><a href="/books/NBK557360/table/ch2.apph.tab53/?report=objectonly" target="object" rid-ob="figobch2apphtab53">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.38 (−0.16, 0.93)</p></div></div></div><div id="ch2.apph.s1.6.9"><h5>Computer CBT vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab54"><a href="/books/NBK557360/table/ch2.apph.tab54/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab54" rid-ob="figobch2apphtab54"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab54/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab54/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab54"><a href="/books/NBK557360/table/ch2.apph.tab54/?report=objectonly" target="object" rid-ob="figobch2apphtab54">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.68 (−1.16, −0.19)</p></div></div></div><div id="ch2.apph.s1.6.10"><h5>Group CBT vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab55"><a href="/books/NBK557360/table/ch2.apph.tab55/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab55" rid-ob="figobch2apphtab55"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab55/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab55/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab55"><a href="/books/NBK557360/table/ch2.apph.tab55/?report=objectonly" target="object" rid-ob="figobch2apphtab55">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.42 (−0.08, 0.93)</p></div></div></div><div id="ch2.apph.s1.6.11"><h5>Group CBT vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab56"><a href="/books/NBK557360/table/ch2.apph.tab56/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab56" rid-ob="figobch2apphtab56"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab56/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab56/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab56"><a href="/books/NBK557360/table/ch2.apph.tab56/?report=objectonly" target="object" rid-ob="figobch2apphtab56">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.15 (−0.27, 0.58)</p></div></div></div><div id="ch2.apph.s1.6.12"><h5>Group CBT vs group CBT and parent sessions</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab57"><a href="/books/NBK557360/table/ch2.apph.tab57/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab57" rid-ob="figobch2apphtab57"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab57/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab57/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab57"><a href="/books/NBK557360/table/ch2.apph.tab57/?report=objectonly" target="object" rid-ob="figobch2apphtab57">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.42 (−0.90, 0.06)</p></div></div></div><div id="ch2.apph.s1.6.13"><h5>Group CBT and parent sessions vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab58"><a href="/books/NBK557360/table/ch2.apph.tab58/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab58" rid-ob="figobch2apphtab58"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab58/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab58/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab58"><a href="/books/NBK557360/table/ch2.apph.tab58/?report=objectonly" target="object" rid-ob="figobch2apphtab58">Table</a></h4><p class="float-caption no_bottom_margin">SMD 0.78 (0.25, 1.31)</p></div></div></div><div id="ch2.apph.s1.6.14"><h5>Family therapy vs attention control</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab59"><a href="/books/NBK557360/table/ch2.apph.tab59/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab59" rid-ob="figobch2apphtab59"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab59/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab59/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab59"><a href="/books/NBK557360/table/ch2.apph.tab59/?report=objectonly" target="object" rid-ob="figobch2apphtab59">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.24 (−0.94, 0.45)</p></div></div></div><div id="ch2.apph.s1.6.15"><h5>Family therapy vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab60"><a href="/books/NBK557360/table/ch2.apph.tab60/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab60" rid-ob="figobch2apphtab60"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab60/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab60/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab60"><a href="/books/NBK557360/table/ch2.apph.tab60/?report=objectonly" target="object" rid-ob="figobch2apphtab60">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.29 (−0.74, 0.17)</p></div></div></div><div id="ch2.apph.s1.6.16"><h5>Family therapy vs non-directive supportive therapy (NDST)</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab61"><a href="/books/NBK557360/table/ch2.apph.tab61/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab61" rid-ob="figobch2apphtab61"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab61/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab61/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab61"><a href="/books/NBK557360/table/ch2.apph.tab61/?report=objectonly" target="object" rid-ob="figobch2apphtab61">Table</a></h4><p class="float-caption no_bottom_margin">MD 2.00 (−2.29, 6.29)</p></div></div></div><div id="ch2.apph.s1.6.17"><h5>Online guided self-help vs waiting list/no treatment</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab62"><a href="/books/NBK557360/table/ch2.apph.tab62/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab62" rid-ob="figobch2apphtab62"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab62/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab62/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab62"><a href="/books/NBK557360/table/ch2.apph.tab62/?report=objectonly" target="object" rid-ob="figobch2apphtab62">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.87 (−1.62, −0.12)</p></div></div></div><div id="ch2.apph.s1.6.18"><h5>IPT-A vs waiting list</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab63"><a href="/books/NBK557360/table/ch2.apph.tab63/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab63" rid-ob="figobch2apphtab63"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab63/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab63/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab63"><a href="/books/NBK557360/table/ch2.apph.tab63/?report=objectonly" target="object" rid-ob="figobch2apphtab63">Table</a></h4><p class="float-caption no_bottom_margin">MD −6.12 (−10.48, 1.76)</p></div></div></div><div id="ch2.apph.s1.6.19"><h5>IPT-A vs monitoring</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab64"><a href="/books/NBK557360/table/ch2.apph.tab64/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab64" rid-ob="figobch2apphtab64"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab64/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab64/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab64"><a href="/books/NBK557360/table/ch2.apph.tab64/?report=objectonly" target="object" rid-ob="figobch2apphtab64">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.29 (−0.86, 0.28)</p></div></div></div><div id="ch2.apph.s1.6.20"><h5>IPT-A vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab65"><a href="/books/NBK557360/table/ch2.apph.tab65/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab65" rid-ob="figobch2apphtab65"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab65/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab65/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab65"><a href="/books/NBK557360/table/ch2.apph.tab65/?report=objectonly" target="object" rid-ob="figobch2apphtab65">Table</a></h4><p class="float-caption no_bottom_margin">MD 7.30 (1.37, 13.23)</p></div></div></div><div id="ch2.apph.s1.6.21"><h5>IPT-A vs individual CBT</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab66"><a href="/books/NBK557360/table/ch2.apph.tab66/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab66" rid-ob="figobch2apphtab66"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab66/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab66/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab66"><a href="/books/NBK557360/table/ch2.apph.tab66/?report=objectonly" target="object" rid-ob="figobch2apphtab66">Table</a></h4><p class="float-caption no_bottom_margin">MD −3.58 (−8.04, 0.88)</p></div></div></div><div id="ch2.apph.s1.6.22"><h5>IPT-A vs IPT-A with additional parent sessions</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab67"><a href="/books/NBK557360/table/ch2.apph.tab67/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab67" rid-ob="figobch2apphtab67"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab67/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab67/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab67"><a href="/books/NBK557360/table/ch2.apph.tab67/?report=objectonly" target="object" rid-ob="figobch2apphtab67">Table</a></h4><p class="float-caption no_bottom_margin">MD −8.55 (−15.65, −1.45)</p></div></div></div><div id="ch2.apph.s1.6.23"><h5>IPT-A vs group IPT</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab68"><a href="/books/NBK557360/table/ch2.apph.tab68/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab68" rid-ob="figobch2apphtab68"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab68/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab68/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab68"><a href="/books/NBK557360/table/ch2.apph.tab68/?report=objectonly" target="object" rid-ob="figobch2apphtab68">Table</a></h4><p class="float-caption no_bottom_margin">MD 6.95 (−2.37, 16.27)</p></div></div></div><div id="ch2.apph.s1.6.24"><h5>Psychodynamic psychotherapy vs psychosocial intervention</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab69"><a href="/books/NBK557360/table/ch2.apph.tab69/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab69" rid-ob="figobch2apphtab69"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab69/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab69/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab69"><a href="/books/NBK557360/table/ch2.apph.tab69/?report=objectonly" target="object" rid-ob="figobch2apphtab69">Table</a></h4><p class="float-caption no_bottom_margin">SMD −0.22 (−0.49, 0.05)</p></div></div></div><div id="ch2.apph.s1.6.25"><h5>Behavioural activation vs usual care</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab70"><a href="/books/NBK557360/table/ch2.apph.tab70/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab70" rid-ob="figobch2apphtab70"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab70/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab70/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab70"><a href="/books/NBK557360/table/ch2.apph.tab70/?report=objectonly" target="object" rid-ob="figobch2apphtab70">Table</a></h4><p class="float-caption no_bottom_margin">MD 3.00 (−2.61, 8.61)</p></div></div></div></div></div><div id="ch2.apph.s2"><h4>Network meta-analyses</h4><div id="ch2.apph.s2.1"><h5>Mild depression in 12 to 18 year olds</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab71"><a href="/books/NBK557360/table/ch2.apph.tab71/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab71" rid-ob="figobch2apphtab71"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab71/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab71/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab71"><a href="/books/NBK557360/table/ch2.apph.tab71/?report=objectonly" target="object" rid-ob="figobch2apphtab71">Table</a></h4></div></div></div><div id="ch2.apph.s2.2"><h5>Moderate to severe depression in 5 to 11 year olds</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab72"><a href="/books/NBK557360/table/ch2.apph.tab72/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab72" rid-ob="figobch2apphtab72"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab72/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab72/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab72"><a href="/books/NBK557360/table/ch2.apph.tab72/?report=objectonly" target="object" rid-ob="figobch2apphtab72">Table</a></h4></div></div></div><div id="ch2.apph.s2.3"><h5>Moderate to severe depression in 12 to 18 year olds</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2apphtab73"><a href="/books/NBK557360/table/ch2.apph.tab73/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2apphtab73" rid-ob="figobch2apphtab73"><img class="small-thumb" src="/books/NBK557360/table/ch2.apph.tab73/?report=thumb" src-large="/books/NBK557360/table/ch2.apph.tab73/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.apph.tab73"><a href="/books/NBK557360/table/ch2.apph.tab73/?report=objectonly" target="object" rid-ob="figobch2apphtab73">Table</a></h4></div></div></div></div></div><div id="ch2.appi"><h3>Appendix I. Economic evidence study selection</h3><div id="ch2.appi.fig1" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appif1&p=BOOKS&id=557360_ch2appif1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK557360/bin/ch2appif1.jpg" alt="Image ch2appif1" class="tileshop" title="Click on image to zoom" /></a></div></div></div><div id="ch2.appj"><h3>Appendix J. Economic evidence tables</h3><p id="ch2.appj.et1"><a href="/books/NBK557360/bin/ch2-appj-et1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Download PDF</a><span class="small"> (281K)</span></p></div><div id="ch2.appk"><h3>Appendix K. Health economic evidence profiles</h3><p>None – see the <a href="#ch2.s1.1.8">Summary of Included Health Economic Studies</a> section in the main body of this report.</p></div><div id="ch2.appl"><h3>Appendix L. Costing Exercise</h3><p>A costing exercise was undertaken in order to help the committee consider the opportunity cost of recommending different interventions. Due to the NHS’s fixed budget, any increase in funding leads to withdrawal of funding for other services and therefore health gain foregone. The opportunity cost in this case is therefore the amount of health gain that is lost when one alternative option is chosen. Given the heterogeneity in planned number of sessions per intervention, in average attendance and in staff delivering interventions, this exercise was intended only to provide the committee with rough estimates. Costs could then be considered qualitatively alongside the clinical evidence.</p><p>For each intervention, we obtained ranges for planned number of sessions, session length and patient numbers per session from a representative study included in the systematic review and ratified them with the committee, who made some modifications based on their understanding of current UK practice. Where average attendance was not reported we assumed it would be 63% of the maximum planned, which was the average observed among all trials included in the costing exercise. The committee noted this limitation and that, while there was no robust evidence on differential attendance between interventions, that less intensive interventions are likely to have higher adherence rates and therefore perhaps slightly higher costs than those presented here. We used staffing cost estimates from the PSSRU Unit Costs of Health and Social Care 2017<sup><a href="#ch2.fn1">a</a></sup> for targeted and multi-disciplinary CAMHS team members. Total unit costs including on-costs were £87 and £114 per hour of face-to-face contact time, respectively. These costs are not specific to banding or role because many of the interventions can be delivered by a variety of professionals provided they have had the appropriate training. The committee noted that these costs may have uniformly been overestimates, and particularly so for the less intensive interventions, which they expected largely to be delivered by more junior staff. They also indicated that interventions are often tailored to be less intensive for patients with milder symptoms; the average cost of CBT presented here has been drawn from the IMPACT HTA, which only included severe participants and is therefore likely to be an overestimate for the cost of CBT for the mild population, for example. The committee discussed several other factors that influence the cost of interventions that we did not try to capture due uncertainty; setting, age, success or failure of therapy, region and social class might all play a role in determining attendance. Similarly, we did not include the opportunity cost of attendance, which is also variable depending on the reason for non-attendance. The committee highlighted that non-attendances are managed differently according to setting, to patient severity and intervention type (group vs individual, for example).</p><p>The committee took account of these limitations while considering the evidence but noted that because costs were highly uncertain, any small differences between interventions of comparable intensity should not affect decision making. Ultimately, this costing exercise provided some evidence that group and computer based interventions are likely to be cheaper than individual psychological interventions and that some individual psychological interventions might be more costly than others but as no formal health economic analysis was conducted, these cost estimates were only taken into account qualitatively by the committee alongside other outcomes reported in the review.</p><p id="ch2.appl.tab1"><a href="/books/NBK557360/table/ch2.appl.tab1/?report=objectonly" target="object" rid-ob="figobch2appltab1" class="figpopup">Table 37. Resource use of interventions (63% attendance assumption highlighted)</a></p><p>The average cost estimates for the interventions in <a class="figpopup" href="/books/NBK557360/table/ch2.appl.tab2/?report=objectonly" target="object" rid-figpopup="figch2appltab2" rid-ob="figobch2appltab2">Table 38</a> were calculated by combining the maximum and minimum values for all data. The “best estimate” incorporates the average staff cost, session duration and attendance in studies (or estimates thereof).</p><p id="ch2.appl.tab2"><a href="/books/NBK557360/table/ch2.appl.tab2/?report=objectonly" target="object" rid-ob="figobch2appltab2" class="figpopup">Table 38. Cost estimates for Interventions</a></p><p><a class="figpopup" href="/books/NBK557360/table/ch2.appl.tab3/?report=objectonly" target="object" rid-figpopup="figch2appltab3" rid-ob="figobch2appltab3">Table 39</a> and <a class="figpopup" href="/books/NBK557360/table/ch2.appl.tab4/?report=objectonly" target="object" rid-figpopup="figch2appltab4" rid-ob="figobch2appltab4">Table 40</a> show the average cost estimates alongside selected results from the NMAs (each intervention is compared to waiting list/control). It should be noted that for NMAs where several interventions have a similar mean rank (as in <a class="figpopup" href="/books/NBK557360/table/ch2.appl.tab3/?report=objectonly" target="object" rid-figpopup="figch2appltab3" rid-ob="figobch2appltab3">Table 39</a>), a large amount of uncertainty exists about which of these treatments are better.</p><p id="ch2.appl.tab3"><a href="/books/NBK557360/table/ch2.appl.tab3/?report=objectonly" target="object" rid-ob="figobch2appltab3" class="figpopup">Table 39. Cost estimates and NMA results (12–18 Severe)</a></p><p>Note that some of the cost estimates, particularly for the more intensive interventions like individual CBT may be overestimated in <a class="figpopup" href="/books/NBK557360/table/ch2.appl.tab4/?report=objectonly" target="object" rid-figpopup="figch2appltab4" rid-ob="figobch2appltab4">Table 40</a> as they would be tailored to the mild population.</p><p id="ch2.appl.tab4"><a href="/books/NBK557360/table/ch2.appl.tab4/?report=objectonly" target="object" rid-ob="figobch2appltab4" class="figpopup">Table 40. Cost Estimates and NMA Results (12–18, Mild)</a></p><p>The costing exercise provided some low quality evidence (because of the limitations noted at the start of this appendix) on the expected average cost of the different treatment options, which ranged between £119 for guided self-help and over £1,200 for the more intensive individual psychological interventions. Computer and group based interventions are likely to cost less than individual interventions and lower intensity individual interventions such as BPI are likely to cost less than higher intensity individual interventions such as STPP. None of these cost data account for any costs beyond the initial delivery of the interventions and do not take into account any differences in effectiveness (although it should be noted that very few significant differences in effectiveness between active interventions were observed in the NMAs). A full discussion of the role that these data played in the committee’s decisions can be found in the “cost-effectiveness and resource use” and “benefits and harms” sections of the “committee’s discussion of the evidence” in the main text of this evidence review.</p></div><div id="ch2.appm"><h3>Appendix M. Excluded studies</h3><div id="ch2.appm.s1"><h4>Clinical studies</h4><div id="ch2.appm.s1.1"><h5>Systematic reviews</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appmtab1"><a href="/books/NBK557360/table/ch2.appm.tab1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appmtab1" rid-ob="figobch2appmtab1"><img class="small-thumb" src="/books/NBK557360/table/ch2.appm.tab1/?report=thumb" src-large="/books/NBK557360/table/ch2.appm.tab1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appm.tab1"><a href="/books/NBK557360/table/ch2.appm.tab1/?report=objectonly" target="object" rid-ob="figobch2appmtab1">Table</a></h4><p class="float-caption no_bottom_margin">Systematic review used as a reference for individual RCTs More recent systematic reviews were checked that covered the same topic</p></div></div></div><div id="ch2.appm.s1.2"><h5>RCT</h5><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appmtab2"><a href="/books/NBK557360/table/ch2.appm.tab2/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appmtab2" rid-ob="figobch2appmtab2"><img class="small-thumb" src="/books/NBK557360/table/ch2.appm.tab2/?report=thumb" src-large="/books/NBK557360/table/ch2.appm.tab2/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appm.tab2"><a href="/books/NBK557360/table/ch2.appm.tab2/?report=objectonly" target="object" rid-ob="figobch2appmtab2">Table</a></h4><p class="float-caption no_bottom_margin">Data not reported in an extractable format
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<i>Pair-review paper only reports baseline data. Follow-up data is only reported in the trial registration but standard deviations are too small. Therefore, it is uncertain whether standard deviation or standard</i> <a href="/books/NBK557360/table/ch2.appm.tab2/?report=objectonly" target="object" rid-ob="figobch2appmtab2">(more...)</a></p></div></div></div><div id="ch2.appm.s1.3"><h5>2015 update excluded studies that were also excluded in this review</h5><p>This table is an amended version of the excluded studies table from the 2015 update of this review question. Any references that were potentially relevant to this update due to changes in the protocol (for example in outcomes and interventions) were removed from this table and checked at full text and excluded or included as normal. The remaining references were not checked again at full text screening, but are listed here for reference.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appmtab3"><a href="/books/NBK557360/table/ch2.appm.tab3/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appmtab3" rid-ob="figobch2appmtab3"><img class="small-thumb" src="/books/NBK557360/table/ch2.appm.tab3/?report=thumb" src-large="/books/NBK557360/table/ch2.appm.tab3/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appm.tab3"><a href="/books/NBK557360/table/ch2.appm.tab3/?report=objectonly" target="object" rid-ob="figobch2appmtab3">Table</a></h4></div></div></div></div><div id="ch2.appm.s2"><h4>Economic studies</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appmtab4"><a href="/books/NBK557360/table/ch2.appm.tab4/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appmtab4" rid-ob="figobch2appmtab4"><img class="small-thumb" src="/books/NBK557360/table/ch2.appm.tab4/?report=thumb" src-large="/books/NBK557360/table/ch2.appm.tab4/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appm.tab4"><a href="/books/NBK557360/table/ch2.appm.tab4/?report=objectonly" target="object" rid-ob="figobch2appmtab4">Table</a></h4></div></div></div></div><div id="ch2.appn"><h3>Appendix N. Research recommendations</h3><div id="ch2.appn.s1"><h4>1. What is the clinical and cost effectiveness, post treatment and at longer-term follow-up, of psychological therapies in children aged 5 to 11 years with mild or moderate to severe depression?</h4><p>The majority of the evidence for psychological therapies for mild or moderate to severe depression is derived from RCTs that recruited young people aged 12–18 years. For mild depression, 2 trials (<a class="bibr" href="#ch2.appo.ref63" rid="ch2.appo.ref63">Stark 1987</a> and <a class="bibr" href="#ch2.appo.ref77" rid="ch2.appo.ref77">Weisz 1997</a>) looked at the effects of group CBP versus waiting list/no treatment in 5–11 year olds with mild depression and found a reduction in depression symptoms post treatment and at 6 months follow up, but the trials were small and did not report other outcomes such as functional status and remission. For 5–11 year olds with moderate to severe depression, there were 3 trials that compared psychological therapies to each other (<a class="bibr" href="#ch2.appo.ref18" rid="ch2.appo.ref18">Dietz 2015</a>, <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a> and <a class="bibr" href="#ch2.appo.ref70" rid="ch2.appo.ref70">Tompson 2017</a>), but none of them included a control and so it is unclear whether any of the treatments are better and usual care or waiting list/no treatment. Other trials looked at therapies compared to controls (<a class="bibr" href="#ch2.appo.ref42" rid="ch2.appo.ref42">Liddle 1990</a>, <a class="bibr" href="#ch2.appo.ref78" rid="ch2.appo.ref78">Weisz 2009</a>), but were unable to detect differences in effects for depression symptoms at post-treatment and 6 months. However, the trials were small and it is possible that larger trials would be able to detect an effect.</p><p>As a result, the current update of CG28 has recommendations for mild depression children aged 5–11 years that were made based on the evidence for 12–18 year olds. The recommendations for 5–11 year olds with moderate to severe depression include the more effective therapies from the above trials, with the caveat that it is unclear whether they are better than a control, and the individual CBT which was the most effective treatment for 12–18 year olds. However, it is likely that 5–11 year olds may respond differently to these therapies compared to 12–18 year olds.</p><p>Further research is needed to explore the clinical and cost effectiveness of the psychological therapies compared to controls or other psychological therapies in a larger group of young people aged 5 to 11 years old with mild or moderate to severe depression. Longer follow up times (including 6 months and 1 year) should also be used to determine whether the effects of the interventions are short-lived or maintained over time.</p><p>Research in this area is essential to inform future updates of this guidance and could lead to specific recommendations for the 5–11 year age group, which in turn could help improve patient outcomes.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appntab1"><a href="/books/NBK557360/table/ch2.appn.tab1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appntab1" rid-ob="figobch2appntab1"><img class="small-thumb" src="/books/NBK557360/table/ch2.appn.tab1/?report=thumb" src-large="/books/NBK557360/table/ch2.appn.tab1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appn.tab1"><a href="/books/NBK557360/table/ch2.appn.tab1/?report=objectonly" target="object" rid-ob="figobch2appntab1">Table</a></h4><p class="float-caption no_bottom_margin">Young people aged 5–11 years with mild depression Young people aged 5–11 years with moderate to severe depression</p></div></div></div><div id="ch2.appn.s2"><h4>2. What is the clinical and cost effectiveness, post treatment and at longer follow-up, of supported digital CBT compared with unsupported digital CBT in young people aged 12 to 18 years with mild depression, and what are the key components of the interventions that influence effectiveness?</h4><p>Digital CBT was identified as an effective psychological therapy to treat mild depression in 12–18 year olds, but the underlying evidence came from RCTs using a variety of digital CBT programmes. Digital CBT can also be delivered in a supported manner (with additional contact with a healthcare professional) or as an unsupported intervention (no additional contact). It is unclear whether unsupported or supported digital CBT is more effective and which programmes would be most effective for use in the UK.</p><p>The 2019 update of CG2028 identified a number of digital CBT programmes: SPARX (<a class="bibr" href="#ch2.appo.ref23" rid="ch2.appo.ref23">Fleming 2012</a>; <a class="bibr" href="#ch2.appo.ref47" rid="ch2.appo.ref47">Merry 2012</a>; <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>), Stressbusters (<a class="bibr" href="#ch2.appo.ref60" rid="ch2.appo.ref60">Smith 2015</a>; <a class="bibr" href="#ch2.appo.ref81" rid="ch2.appo.ref81">Wright 2017</a>), The Journal (<a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>), iCBT (<a class="bibr" href="#ch2.appo.ref71" rid="ch2.appo.ref71">Topooco 2018</a>) and Grasp the Opportunity (<a class="bibr" href="#ch2.appo.ref32" rid="ch2.appo.ref32">Ip 2016</a>). They have been tested in a variety of countries, but only the Stressbusters programme (<a class="bibr" href="#ch2.appo.ref60" rid="ch2.appo.ref60">Smith 2015</a>, <a class="bibr" href="#ch2.appo.ref81" rid="ch2.appo.ref81">Wright 2017</a>) has been tested in the UK. These interventions share key components including psychoeducation, relaxation, analysis of behaviour, behavioural activation, basic communication and interpersonal skills, emotional recognition, dealing with strong emotions, problem solving, cognitive restructuring (identifying thoughts, challenging unhelpful/negative thoughts), mindfulness, and relapse prevention, but it is unclear which components influence effectiveness.</p><p>Further research is needed to identify key components of digital CBT; the most effective programme for a UK population and whether supported programmes are more effective than unsupported ones to ensure that suitable form of digital CBT is available to young people aged 12–18 years old with mild depression. Longer follow up times (including 6 months and 1 year) should also be used to determine whether the effects of the interventions are short-lived or maintained over time.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appntab2"><a href="/books/NBK557360/table/ch2.appn.tab2/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appntab2" rid-ob="figobch2appntab2"><img class="small-thumb" src="/books/NBK557360/table/ch2.appn.tab2/?report=thumb" src-large="/books/NBK557360/table/ch2.appn.tab2/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appn.tab2"><a href="/books/NBK557360/table/ch2.appn.tab2/?report=objectonly" target="object" rid-ob="figobch2appntab2">Table</a></h4><p class="float-caption no_bottom_margin"><i>Population:</i> Young people aged 12 to 18 with mild depression</p></div></div></div><div id="ch2.appn.s3"><h4>3. What is the clinical and cost effectiveness, post treatment and at longer follow-up, of family therapy, psychodynamic psychotherapy and IPT-A (IPT for adolescents) compared with each other and with individual CBT in young people aged 12 to 18 years with moderate to severe depression?</h4><p>The current update of CG28 includes a recommendation for IPT-A, family therapy or STPP to treat moderate to severe depression in children and young people should individual CBT not meet the individual’s needs or preferences. These therapies were recomended as second line options due to limitations in the evidence base.</p><p><a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a> and <a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a> trials tested psychodynamic psychotherapy against family therapy, and individual CBT/brief psychosocial intervention respectively, but either they did not report results for all outcomes of interest or the results were reported for short follow up times. Family therapy was also trialled against individual CBT (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>), but this trial only reported results post treatment. Four studies looked at IPT-A compared to other interventions or controls (<a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rossello 1999</a>, <a class="bibr" href="#ch2.appo.ref48" rid="ch2.appo.ref48">Mufson 1999</a>, <a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>, <a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>) and there was similar shortage of outcomes reported or short follow up times.</p><p>In order to support and strengthen the recommendation for IPT-A, psychodynamic psychotherapy and family therapy, further research is needed to explore the clinical and cost effectiveness of these therapies compared to each other and individual CBT in a larger group of young people aged 12–18 years old with moderate to severe depression. Longer follow up times (including 6 months and 1 year) should also be used to determine whether the effects of the interventions are short-lived or maintained over time and wider range of outcomes should be reported.</p><p>Research in this area is could inform future updates of key recommendations in this guidance, which in turn could help improve patient outcomes.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appntab3"><a href="/books/NBK557360/table/ch2.appn.tab3/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appntab3" rid-ob="figobch2appntab3"><img class="small-thumb" src="/books/NBK557360/table/ch2.appn.tab3/?report=thumb" src-large="/books/NBK557360/table/ch2.appn.tab3/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appn.tab3"><a href="/books/NBK557360/table/ch2.appn.tab3/?report=objectonly" target="object" rid-ob="figobch2appntab3">Table</a></h4><p class="float-caption no_bottom_margin"><i>Population:</i> Young people aged 12 to 18 years with moderate to severe depression</p></div></div></div><div id="ch2.appn.s4"><h4>4. What is the clinical and cost effectiveness, post treatment and at longer-term follow-up, of a brief psychosocial intervention as reported by the IMPACT trial, but delivered by practitioners other than psychiatrists and in other settings, including primary care, to young people aged 12 to 18 years with mild or moderate to severe depression?</h4><p>The current update of CG28 includes a weak recommendation for a brief psychosocial intervention (BPI) to treat moderate to severe depression in children and young people. However, this recommendation is based on an NMA using data on this intervention from a single trial. The IMPACT trial (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>) assessed the medium-term effects and costs of BPI compared to CBT and short-term psychoanalytic psychotherapy in adolescents with a diagnosis of depression at recruitment. It found no evidence for the superiority of CBT or short-term psychoanalytic psychotherapy compared with the BPI, suggesting that BPI could be an effective intervention in its own right. However, a high proportion of people conducting BPI within the study were psychiatrists and it is unclear whether the intervention would be equally effective if carried out by more junior staff. In addition, these treatments were designed for delivery by practitioners working in routine NHS CAMHS settings and it is unclear whether the intervention would be equally effective if carried out in a primary care setting. As a result, further research is needed to explore the clinical and cost effectiveness of the BPI when it is delivered by other practitioners and in other settings, including primary care. In addition, this intervention has yet to be tested in young people with mild depression.</p><p>It is important to have a sufficiently large study population to enable the relative superiority of BPI compared to other interventions to be examined and to include a control arm to confirm that BPI is more effective than for example, waiting list. Longer follow up times (including 6 months and 1 year) should also be used to determine whether the effects of the interventions are short-lived or maintained over time.</p><p>Research in this area could strengthen the recommendation for BPI, and may increase the pool of healthcare professionals who can deliver the intervention and expand the settings in which the intervention can be carried out. These changes could in turn help improve patient access to treatment and outcomes.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appntab4"><a href="/books/NBK557360/table/ch2.appn.tab4/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appntab4" rid-ob="figobch2appntab4"><img class="small-thumb" src="/books/NBK557360/table/ch2.appn.tab4/?report=thumb" src-large="/books/NBK557360/table/ch2.appn.tab4/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appn.tab4"><a href="/books/NBK557360/table/ch2.appn.tab4/?report=objectonly" target="object" rid-ob="figobch2appntab4">Table</a></h4><p class="float-caption no_bottom_margin">Young people aged 12 to 18 years with mild depression Young people aged 12 to 18 years moderate to severe depression</p></div></div></div><div id="ch2.appn.s5"><h4>5. What is the clinical and cost effectiveness, post treatment and at longer-term follow-up, of behavioural activation compared with other psychological therapies in children aged 5 to 11 and young people aged 12 to 18 years with mild or moderate to severe depression?</h4><p>Behavioural activation may meet the specific needs of some children and young people with mild or moderate to severe depression. It could be particularly suitable for a large number of children and young people who might struggle with the concepts of CBT. It could also be suitable for younger children and older ones who are less into talking and more into doing things or for children with learning disabilities or neurodevelopmental disorders.</p><p>Behavioural activation is particularly helpful in treating the symptoms of withdrawal from social activities, inactivity and avoidance which are common symptoms for young people who experience depression. It is relatively simple to administer and can be used as part of a broad cognitive approach, however it is particularly useful for young people as it can be used as a stand-alone intervention and unlike cognitive base approaches, does not require the therapists to challenge the young person’s thinking. It can be considered particularly useful for this age group as it is developmentally appropriate and does not require the young person to access thought processes because many young people may struggle to access thinking processes, either due to their developmentally immaturity or as a consequence of their depression.</p><p>Only 1 RCT (<a class="bibr" href="#ch2.appo.ref46" rid="ch2.appo.ref46">McCauley 2016</a>) was identified which compared behavioural activation with usual care in adolescents with moderate to severe depresssion. The RCT found no significant differences between behavioural activation and usual care in depression symptoms and functional status at post-treatment. However, the sample size was small (60 participants), and it is possible that a larger trial would be able to detect an effect on these outcomes.</p><p>Further research is needed to explore the clinical and cost effectiveness of behavioural activation compared other psychological therapies in a larger group of young people aged 12–18 years old with moderate to severe depression. It may also be an appropriate therapy for children aged 5–11 years with modeate to severe depression and for children and young people with mild depression. Longer follow up times (including 6 months and 1 year) should also be used to determine whether the effects of the interventions are short-lived or maintained over time.</p><p>Research in this area could inform future updates of key recommendations in this guidance, which in turn could help improve patient outcomes.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appntab5"><a href="/books/NBK557360/table/ch2.appn.tab5/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appntab5" rid-ob="figobch2appntab5"><img class="small-thumb" src="/books/NBK557360/table/ch2.appn.tab5/?report=thumb" src-large="/books/NBK557360/table/ch2.appn.tab5/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appn.tab5"><a href="/books/NBK557360/table/ch2.appn.tab5/?report=objectonly" target="object" rid-ob="figobch2appntab5">Table</a></h4><p class="float-caption no_bottom_margin">Children aged 5–11 years with mild depression Children aged 5–11 years with moderate to severe depression</p></div></div></div><div id="ch2.appn.s6"><h4>6. What is the clinical and cost effectiveness, post treatment and at longer-term follow-up, of group mindfulness compared with other psychological therapies in young people aged 12 to 18 years with mild depression?</h4><p>In the NMAs included in this review, group mindfulness was better than waiting list/no treatment at reducing depression symptoms post treatment and at 6 months, but this intervention was not recommended because the effect was not sustained longer term and no data was available for effects on other outcomes such as functional status. The data on this intervention came from a single, small US based study with 33 female participants who were at risk of type 2 diabetes due to being overweight or obese that compared mindfulness group to group CBT (<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>). The evidence behind the results for group mindfulness were considered to be insufficiently robust to change UK practice at this time.</p><p>Further research is needed to explore the clinical and cost effectiveness of group mindfulness compared to other psychological therapies in a larger group of young people aged 12–18 years old with mild depression. Longer follow up times (including 6 months and 1 year) should also be used to determine whether the effects of the interventions are short-lived or maintained over time.</p><p>Research in this area could inform future updates of key recommendations in this guidance, which in turn could help improve patient outcomes.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figch2appntab6"><a href="/books/NBK557360/table/ch2.appn.tab6/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figch2appntab6" rid-ob="figobch2appntab6"><img class="small-thumb" src="/books/NBK557360/table/ch2.appn.tab6/?report=thumb" src-large="/books/NBK557360/table/ch2.appn.tab6/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="ch2.appn.tab6"><a href="/books/NBK557360/table/ch2.appn.tab6/?report=objectonly" target="object" rid-ob="figobch2appntab6">Table</a></h4><p class="float-caption no_bottom_margin">Young people aged 12 to 18 years with mild depression Group mindfulness</p></div></div></div></div><div id="ch2.appo"><h3>Appendix O. References</h3><ul class="simple-list"><div id="ch2.rl.r1"><h4>Clinical studies</h4><ul class="simple-list"><div id="ch2.rl.r1.1"><h5>Included studies – NMA</h5><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref1">Zhou
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Xinyu, Hetrick
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Sarah E, Cuijpers
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Pim, Qin
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Bin, Barth
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Jurgen, Whittington
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Craig J, Cohen
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David, Del Giovane, Cinzia, Liu
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Yiyun, Michael
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Kurt D, Zhang
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Yuqing, Weisz
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John R, and Xie
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Peng (2015) Comparative efficacy and acceptability of psychotherapies for depression in children and adolescents: A systematic review and network meta-analysis. World psychiatry: official journal of the World Psychiatric Association (WPA)
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14(2), 207–22 [<a href="/pmc/articles/PMC4471978/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4471978</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26043339" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26043339</span></a>]</div></p></li></ul></div><div id="ch2.rl.r1.2"><h5>Included studies – RCTs</h5><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref2">Ackerson
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J, Scogin
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F, McKendree-Smith
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N, and Lyman
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RD (1998) Cognitive bibliotherapy for mild and moderate adolescent depressive symptomatology.. Journal of consulting and clinical psychology
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66(4), 685–90 [<a href="https://pubmed.ncbi.nlm.nih.gov/9735587" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9735587</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref3">Alavi
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A, Sharifi
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B, Ghanizadeh
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A, and Dehbozorgi
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G (2013) Effectiveness of cognitive-behavioral therapy in decreasing suicidal ideation and hopelessness of the adolescents with previous suicidal attempts. Iranian journal of pediatrics
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23(4), 467–72 [<a href="/pmc/articles/PMC3883378/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3883378</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24427502" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24427502</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref4">Asarnow
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Joan Rosenbaum, Scott
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Cynthia V, and Mintz
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Jim (2002) A Combined Cognitive–Behavioral Family Education Intervention for Depression in Children: A Treatment Development Study. Cognitive Therapy and Research
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26(2), 221–229</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref5">Bella-Awusah
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Tolulope, Ani
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Cornelius, Ajuwon
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Ademola, and Omigbodun
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Olayinka (2015) Effectiveness of brief school-based, group cognitive behavioural therapy for depressed adolescents in south west Nigeria. Child and Adolescent Mental Health
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21(1), 44–50 [<a href="https://pubmed.ncbi.nlm.nih.gov/32680363" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32680363</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref6">Bolton
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Paul, Bass
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Judith, Betancourt
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Theresa, Speelman
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Liesbeth, Onyango
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Grace, Clougherty
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Kathleen F, Neugebauer
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Richard, Murray
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Laura, and Verdeli
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Helen (2007) Interventions for depression symptoms among adolescent survivors of war and displacement in northern Uganda: a randomized controlled trial. JAMA
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298(5), 519–27 [<a href="https://pubmed.ncbi.nlm.nih.gov/17666672" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17666672</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref7">Brent
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DA, Holder
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D, Kolko
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D, Birmaher
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B, Baugher
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M, Roth
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C, Iyengar
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S, and Johnson
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BA (1997) A clinical psychotherapy trial for adolescent depression comparing cognitive, family, and supportive therapy.. Archives of general psychiatry
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54(9), 877–85 [<a href="https://pubmed.ncbi.nlm.nih.gov/9294380" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9294380</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref8">Brent
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David A, Brunwasser
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Steven M, Hollon
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Steven D, Weersing
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V Robin, Clarke
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Gregory N, Dickerson
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John F, Beardslee
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William R, Gladstone
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Tracy R. G, Porta
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Giovanna, Lynch
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Frances L, Iyengar
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Satish, and Garber
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Judy (2015) Effect of a Cognitive-Behavioral Prevention Program on Depression 6 Years After Implementation Among At-Risk Adolescents: A Randomized Clinical Trial. JAMA psychiatry
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72(11), 1110–8 [<a href="/pmc/articles/PMC4635056/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4635056</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26421861" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26421861</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref9">Charkhandeh
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M, Talib
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MA, and Hunt
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CJ (2016) The clinical effectiveness of cognitive behavior therapy and an alternative medicine approach in reducing symptoms of depression in adolescents.. Psychiatry research
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239, 325–30 [<a href="https://pubmed.ncbi.nlm.nih.gov/27058159" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27058159</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref10">Clarke
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Gregory N, Hawkins
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Wesley, Murphy
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Mary, Sheeber
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Lisa B, Lewinsohn
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Peter M, and Seeley
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John R (1995) Targeted Prevention of Unipolar Depressive Disorder in an At-Risk Sample of High School Adolescents: A Randomized Trial of a Group Cognitive Intervention. Journal of the American Academy of Child & Adolescent Psychiatry
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34(3), 312–321 [<a href="https://pubmed.ncbi.nlm.nih.gov/7896672" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7896672</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref11">Clarke
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GN, Rohde
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P, Lewinsohn
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PM, Hops
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H, and Seeley
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JR (1999) Cognitive-behavioral treatment of adolescent depression: efficacy of acute group treatment and booster sessions.. Journal of the American Academy of Child and Adolescent Psychiatry
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38(3), 272–9 [<a href="https://pubmed.ncbi.nlm.nih.gov/10087688" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10087688</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref12">Clarke
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GN, Hornbrook
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M, Lynch
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F, Polen
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M, Gale
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J, Beardslee
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W, O’Connor
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E, and Seeley
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J (2001) A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents. Archives of general psychiatry
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58(12), 1127–34 [<a href="https://pubmed.ncbi.nlm.nih.gov/11735841" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11735841</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref13">Clarke
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Gregory N, Hornbrook
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Mark, Lynch
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Frances, Polen
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Michael, Gale
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John, O’connor
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Elizabeth, Seeley
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John R, and Debar
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Lynn (2002) Group Cognitive-Behavioral Treatment for Depressed Adolescent Offspring of Depressed Parents in a Health Maintenance Organization. Journal of the American Academy of Child & Adolescent Psychiatry
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41(3), 305–313 [<a href="https://pubmed.ncbi.nlm.nih.gov/11886025" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11886025</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref14">Clarke
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G, DeBar
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LL, Pearson
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JA, Dickerson
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JF, Lynch
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FL, Gullion
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CM, and Leo
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MC (2016) Cognitive Behavioral Therapy in Primary Care for Youth Declining Antidepressants: A Randomized Trial.. Pediatrics
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77(3), 383–96 [<a href="/pmc/articles/PMC3010274/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3010274</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19485581" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19485581</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref79">Wijnhoven
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LA, Creemers
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DH, Vermulst
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AA, Scholte
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RH, and Engels
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RC (2014) Randomized controlled trial testing the effectiveness of a depression prevention program (‘Op Volle Kracht’) among adolescent girls with elevated depressive symptoms. Journal of abnormal child psychology
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42(2), 217–28 [<a href="https://pubmed.ncbi.nlm.nih.gov/23893066" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23893066</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref80">Wood
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A, Harrington
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R, and Moore
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A (1996) Controlled trial of a brief cognitive-behavioural intervention in adolescent patients with depressive disorders.. Journal of child psychology and psychiatry, and and allied disciplines
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37(6), 737–46 [<a href="https://pubmed.ncbi.nlm.nih.gov/8894955" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8894955</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref81">Wright
|
|
Barry, Tindall
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|
Lucy, Littlewood
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Elizabeth, Allgar
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Victoria, Abeles
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Paul, Trepel
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Dominic, and Ali
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Shehzad (2017) Computerised cognitive-behavioural therapy for depression in adolescents: feasibility results and 4-month outcomes of a UK randomised controlled trial. BMJ open
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7(1), e012834 [<a href="/pmc/articles/PMC5278287/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5278287</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28132000" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28132000</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref82">Young
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Jami F, Mufson
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Laura, and Davies
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Mark (2006) Efficacy of Interpersonal Psychotherapy-Adolescent Skills Training: an indicated preventive intervention for depression. Journal of child psychology and psychiatry, and and allied disciplines
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47(12), 1254–62 [<a href="https://pubmed.ncbi.nlm.nih.gov/17176380" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17176380</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref83">Young
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Jami F, Gallop
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Robert, and Mufson
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Laura (2009) Mother-child conflict and its moderating effects on depression outcomes in a preventive intervention for adolescent depression. Journal of clinical child and adolescent psychology: the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, and Division 53
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38(5), 696–704 [<a href="https://pubmed.ncbi.nlm.nih.gov/20183654" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20183654</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref84">Young
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JF, Mufson
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L, and Gallop
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R (2010) Preventing depression: a randomized trial of interpersonal psychotherapy-adolescent skills training.. Depression and anxiety
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27(5), 426–33 [<a href="/pmc/articles/PMC3209539/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3209539</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20112246" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20112246</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref85">Young
|
|
Jami F, Benas
|
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Jessica S, Schueler
|
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Christie M, Gallop
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Robert, Gillham
|
|
Jane E, and Mufson
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Laura (2016) A Randomized Depression Prevention Trial Comparing Interpersonal Psychotherapy--Adolescent Skills Training to Group Counseling in Schools. Prevention science: the official journal of the Society for Prevention Research
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17(3), 314–24 [<a href="/pmc/articles/PMC5467441/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5467441</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26638219" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26638219</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref86">Young
|
|
Jami F, Jones
|
|
Jason D, Sbrilli
|
|
Marissa D, Benas
|
|
Jessica S, Spiro
|
|
Carolyn N, Haimm
|
|
Caroline A, Gallop
|
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Robert, Mufson
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Laura, and Gillham
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Jane E (2018) Long-Term Effects from a School-Based Trial Comparing Interpersonal Psychotherapy-Adolescent Skills Training to Group Counseling. Journal of clinical child and adolescent psychology: the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, and Division
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53, 1–10 [<a href="/pmc/articles/PMC6320721/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6320721</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29979882" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29979882</span></a>]</div></p></li></ul></div><div id="ch2.rl.r1.3"><h5>Excluded studies – Systematic reviews</h5><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref87">Aalbers
|
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S, Fusar-Poli
|
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L, Freeman
|
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R E, Spreen
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M, Ket
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J C. F, Vink
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A C, Maratos
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A, Crawford
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M, Chen
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X J, and Gold
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C (2017) Music therapy for depression. Cochrane Database of Systematic Reviews
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2017(11), CD004517 [<a href="/pmc/articles/PMC6486188/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6486188</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29144545" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29144545</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref88">Abbass
|
|
Allan A, Rabung
|
|
Sven, Leichsenring
|
|
Falk, Refseth
|
|
Johanne S, and Midgley
|
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Nick (2013) Psychodynamic psychotherapy for children and adolescents: a meta-analysis of short-term psychodynamic models. Journal of the American Academy of Child and Adolescent Psychiatry
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52(8), 863–75 [<a href="https://pubmed.ncbi.nlm.nih.gov/23880496" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23880496</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref89">Arnberg
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Alexandra, and Ost
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Lars-Goran (2014) CBT for children with depressive symptoms: a meta-analysis. Cognitive behaviour therapy
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|
43(4), 275–88 [<a href="https://pubmed.ncbi.nlm.nih.gov/25248459" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25248459</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref90">Bernecker
|
|
Samantha L, Coyne
|
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Alice E, Constantino
|
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Michael J, and Ravitz
|
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Paula (2017) For whom does interpersonal psychotherapy work? A systematic review. Clinical psychology review
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56, 82–93 [<a href="https://pubmed.ncbi.nlm.nih.gov/28710917" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28710917</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref91">Bevan Jones, Rhys, Thapar
|
|
Anita, Stone
|
|
Zoe, Thapar
|
|
Ajay, Jones
|
|
Ian, Smith
|
|
Daniel, and Simpson
|
|
Sharon (2018) Psychoeducational interventions in adolescent depression: A systematic review. Patient education and counseling
|
|
101(5), 804–816 [<a href="/pmc/articles/PMC5933524/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5933524</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29103882" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29103882</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref92">Chi
|
|
Xinli, Bo
|
|
Ai, Liu
|
|
Tingting, Zhang
|
|
Peichao, and Chi
|
|
Iris (2018) Effects of Mindfulness-Based Stress Reduction on Depression in Adolescents and Young Adults: A Systematic Review and Meta-Analysis. Frontiers in psychology
|
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9, 1034 [<a href="/pmc/articles/PMC6021542/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6021542</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29977221" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29977221</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref93">Compton
|
|
S N, March
|
|
J S, Brent
|
|
D, Albano
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A M, Weersing
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V R, and Curry
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J (2004) Cognitive-behavioral psychotherapy for anxiety and depressive disorders in children and adolescents: An evidence-based medicine review. Journal of the American Academy of Child and Adolescent Psychiatry
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43(8), 930–959 [<a href="https://pubmed.ncbi.nlm.nih.gov/15266189" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15266189</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref94">Cook
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N E, and Gorraiz
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M (2016) Dialectical behavior therapy for nonsuicidal self-injury and depression among adolescents: Preliminary meta-analytic evidence. Child and Adolescent Mental Health
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21(2), 81–89 [<a href="https://pubmed.ncbi.nlm.nih.gov/32680373" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32680373</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref95">Crowe
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Katherine, and McKay
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Dean (2017) Efficacy of cognitive-behavioral therapy for childhood anxiety and depression. Journal of anxiety disorders
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49, 76–87 [<a href="https://pubmed.ncbi.nlm.nih.gov/28460329" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28460329</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref96">Devenish
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|
B, Berk
|
|
L, and Lewis
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|
AJ (2016) The treatment of suicidality in adolescents by psychosocial interventions for depression: A systematic literature review.. The Australian and New Zealand journal of psychiatry
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50(8), 726–40 [<a href="https://pubmed.ncbi.nlm.nih.gov/26896044" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26896044</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref97">Dolle
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|
Kathrin, and Schulte-Korne
|
|
Gerd (2013) The treatment of depressive disorders in children and adolescents. Deutsches Arzteblatt international
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|
110(50), 854–60 [<a href="/pmc/articles/PMC3888928/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3888928</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24399027" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24399027</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref98">Ebert
|
|
DD, Zarski
|
|
AC, Christensen
|
|
H, Stikkelbroek
|
|
Y, Cuijpers
|
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P, Berking
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M, and Riper
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H (2015) Internet and computer-based cognitive behavioral therapy for anxiety and depression in youth: a meta-analysis of randomized controlled outcome trials.. PloS one
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10(3), e0119895 [<a href="/pmc/articles/PMC4364968/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4364968</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25786025" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25786025</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref99">Erford
|
|
Bradley T, Erford
|
|
Breann M, Lattanzi
|
|
Gina, Weller
|
|
Janet, Schein
|
|
Hallie, Wolf
|
|
Emily, Hughes
|
|
Meredith, Darrow
|
|
Jenna, Savin-Murphy
|
|
Janet, and Peacock
|
|
Elizabeth (2011) Counseling outcomes from 1990 to 2008 for school-age youth with depression: A meta-analysis. Journal of Counseling & Development
|
|
89(4), 439–457</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref100">Fleming
|
|
Theresa M, Cheek
|
|
Colleen, Merry
|
|
Sally N, Thabrew
|
|
Hiran, Bridgman
|
|
Heather, Stasiak
|
|
Karolina, Shepherd
|
|
Matthew, Perry
|
|
Yael, and Hetrick
|
|
Sarah (2014) Serious games for the treatment or prevention of depression: A systematic review. Revista de Psicopatologia y Psicologia Clinica
|
|
19(3), 227–242</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref101">Forti-Buratti
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|
MA, Saikia
|
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R, Wilkinson
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|
EL, and Ramchandani
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PG (2016) Psychological treatments for depression in pre-adolescent children (12 years and younger): systematic review and meta-analysis of randomised controlled trials.. European child & adolescent psychiatry
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25(10), 1045–54 [<a href="https://pubmed.ncbi.nlm.nih.gov/26969618" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26969618</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref102">Garber
|
|
Judy, Brunwasser
|
|
Steven M, Zerr
|
|
Argero A, Schwartz
|
|
Karen T. G, Sova
|
|
Karen, and Weersing
|
|
V Robin (2016) Treatment and Prevention of Depression and Anxiety in Youth: Test of Cross-Over Effects. Depression and anxiety
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33(10), 939–959 [<a href="/pmc/articles/PMC5094283/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5094283</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27699941" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27699941</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref103">Garcia-Escalera
|
|
Julia, Chorot
|
|
Paloma, Valiente
|
|
Rosa M, Reales
|
|
Jose M, and Sandin
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Bonifacio (2016) Efficacy of transdiagnostic cognitive-behavioral therapy for anxiety and depression in adults, children and adolescents: A meta-analysis. Revista de Psicopatologia y Psicologia Clinica
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|
21(3), 147–175</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref104">Gertler
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|
Paul, Tate
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|
Robyn L, and Cameron
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|
Ian D (2015) Non-pharmacological interventions for depression in adults and children with traumatic brain injury. The Cochrane database of systematic reviews (12), CD009871 [<a href="/pmc/articles/PMC8761477/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8761477</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26663136" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26663136</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref105">Goodyer
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|
Ian M, and Wilkinson
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Paul O (2018) Practitioner Review: Therapeutics of unipolar major depressions in adolescents. Journal of child psychology and psychiatry, and and allied disciplines, [<a href="https://pubmed.ncbi.nlm.nih.gov/29939396" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29939396</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref106">Grist
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Rebecca, Porter
|
|
Joanna, and Stallard
|
|
Paul (2017) Mental Health Mobile Apps for Preadolescents and Adolescents: A Systematic Review. Journal of medical Internet research
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19(5), e176 [<a href="/pmc/articles/PMC5465380/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5465380</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28546138" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28546138</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref107">Gualano
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|
M R, Bert
|
|
F, Martorana
|
|
M, Voglino
|
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G, Andriolo
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V, Thomas
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R, Gramaglia
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C, Zeppegno
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P, and Siliquini
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58, 49–58 [<a href="https://pubmed.ncbi.nlm.nih.gov/28993103" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28993103</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref108">Hollis
|
|
Chris, Falconer
|
|
Caroline J, Martin
|
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Jennifer L, Whittington
|
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Craig, Stockton
|
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Sarah, Glazebrook
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Cris, and Davies
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E Bethan (2017) Annual Research Review: Digital health interventions for children and young people with mental health problems - a systematic and meta-review. Journal of child psychology and psychiatry, and and allied disciplines
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58(4), 474–503 [<a href="https://pubmed.ncbi.nlm.nih.gov/27943285" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27943285</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref109">Hunnicutt
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Hollenbaugh, Karen
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Michelle, and Lenz
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A Stephen (2018) Preliminary evidence for the effectiveness of dialectical behavior therapy for adolescents. Journal of Counseling & Development
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96(2), 119–131</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref110">Kallapiran
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K, Koo
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S, Kirubakaran
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R, and Hancock
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K (2015) Review: Effectiveness of mindfulness in improving mental health symptoms of children and adolescents: A meta-analysis. Child and Adolescent Mental Health
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20(4), 182–194 [<a href="https://pubmed.ncbi.nlm.nih.gov/32680348" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32680348</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref111">Keles
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Serap, and Idsoe
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Thormod (2018) A meta-analysis of group Cognitive Behavioral Therapy (CBT) interventions for adolescents with depression. Journal of adolescence
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67, 129–139 [<a href="https://pubmed.ncbi.nlm.nih.gov/29957492" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29957492</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref112">Livheim
|
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Fredrik, Hayes
|
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Louise, Ghaderi
|
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Ata, Magnusdottir
|
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Thora, Hogfeldt
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Anna, Rowse
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Julie, Turner
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Simone, Hayes
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Steven C, and Tengstrom
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Anders (2015) The effectiveness of Acceptance and Commitment Therapy for adolescent mental health: Swedish and Australian pilot outcomes. Journal of Child and Family Studies
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24(4), 1016–1030</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref113">Loades
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Maria E, Sheils
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Elizabeth A, and Crawley
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Esther (2016) Treatment for paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) and comorbid depression: a systematic review. BMJ open
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Tamara, and Conroy-Hiller
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Tiffany (2004) Comparing the effectiveness of cognitive behaviour therapy using individual or group therapy in the treatment of depression. JBI library of systematic reviews
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C, Pennant
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M, Whittington
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C, Naqvi
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S, Sealey
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Vicky, and Nelson
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E Andrea (2015) Dance movement therapy for depression. The Cochrane database of systematic reviews (2), CD009895 [<a href="/pmc/articles/PMC8928931/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8928931</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25695871" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25695871</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref118">Midgley
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N, O’Keeffe
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S, French
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L, and Kennedy
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E (2017) Psychodynamic psychotherapy for children and adolescents: an updated narrative review of the evidence base. Journal of Child Psychotherapy
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Katherine L, Kim
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Johnny S, Springer
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David W, and Learman
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Joy A (2013) A systematic and empirical review of mindfulness interventions with adolescents: A potential fit for delinquency intervention. Best Practices in Mental Health: An International Journal
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9(1), 1–19</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref120">Morina
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Nexhmedin, Malek
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Mina, Nickerson
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Angela, and Bryant
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Richard A (2017) Psychological interventions for post-traumatic stress disorder and depression in young survivors of mass violence in low- and middle-income countries: meta-analysis. The British journal of psychiatry: the journal of mental science
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Sina, Rohde
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Paul, Gau
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Jeff M, and Stice
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Eric (2015) Moderators of the effects of indicated group and bibliotherapy cognitive behavioral depression prevention programs on adolescents’ depressive symptoms and depressive disorder onset. Behaviour research and therapy
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Matthew P, and Elson
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Damian M (2018) Working through the blues: A meta-analysis on interpersonal psychotherapy for depressed adolescents (IPT-A). Children and Youth Services Review
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87, 123–129</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref123">Pennant
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Mary E, Loucas
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Christina E, Whittington
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Craig, Creswell
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Cathy, Fonagy
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Peter, Fuggle
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Peter, Kelvin
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Raphael, Naqvi
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Tim, Expert Advisory, and Group (2015) Computerised therapies for anxiety and depression in children and young people: a systematic review and meta-analysis. Behaviour research and therapy
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Juncai, Zhou
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Xinyu, Liu
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Lanxiang, Zhang
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Yuqing, Yang
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Lining, Yuan
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Shuai, Zhang
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Hanpin, Han
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Yu, Zou
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Dezhi, and Xie
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Peng (2017) Efficacy and acceptability of interpersonal psychotherapy for depression in adolescents: A meta-analysis of randomized controlled trials. Psychiatry research
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253, 226–232 [<a href="https://pubmed.ncbi.nlm.nih.gov/28391140" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28391140</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref125">Rasing
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Sanne P. A, Creemers
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Daan H. M, Janssens
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Jan M. A. M, and Scholte
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Ron H. J (2017) Depression and Anxiety Prevention Based on Cognitive Behavioral Therapy for At-Risk Adolescents: A Meta-Analytic Review. Frontiers in psychology
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Jazmin A, Mufson
|
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Laura, Greenhill
|
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Laurence L, Gould
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Madelyn S, Fisher
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Prudence W, Tarlow
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Naomi, and Rynn
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Moira A (2014) Web-based interventions for youth internalizing problems: a systematic review. Journal of the American Academy of Child and Adolescent Psychiatry
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53(12), 1254–1270.e5 [<a href="https://pubmed.ncbi.nlm.nih.gov/25457924" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25457924</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref127">Rice
|
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Simon M, Goodall
|
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Joanne, Hetrick
|
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Sarah E, Parker
|
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Alexandra G, Gilbertson
|
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Tamsyn, Amminger
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G Paul, Davey
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Christopher G, McGorry
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Patrick D, Gleeson
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John, and Alvarez-Jimenez
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Mario (2014) Online and social networking interventions for the treatment of depression in young people: a systematic review. Journal of medical Internet research
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16(9), e206 [<a href="/pmc/articles/PMC4180352/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4180352</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25226790" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25226790</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref128">Rodgers
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M, Asaria
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M, Walker
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S, McMillan
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D, Lucock
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M, Harden
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M, Palmer
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S, and Eastwood
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A (2012) The clinical effectiveness and cost-effectiveness of low-intensity psychological interventions for the secondary prevention of relapse after depression: A systematic review. Health Technology Assessment
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16(28), 1–129 [<a href="/pmc/articles/PMC4781580/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4781580</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22642789" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22642789</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref129">Rohde
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P, Briere
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F N, and Stice
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E (2018) Major depression prevention effects for a cognitive-behavioral adolescent indicated prevention group intervention across four trials. Behaviour Research and Therapy
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100, 1–6 [<a href="/pmc/articles/PMC5794620/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5794620</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29107762" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29107762</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref130">Spinhoven
|
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Philip, Klein
|
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Nicola, Kennis
|
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Mitzy, Cramer
|
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Angelique O. J, Siegle
|
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Greg, Cuijpers
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Pim, Ormel
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Johan, Hollon
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Steve D, and Bockting
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Claudi L (2018) The effects of cognitive-behavior therapy for depression on repetitive negative thinking: A meta-analysis. Behaviour research and therapy
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106, 71–85 [<a href="https://pubmed.ncbi.nlm.nih.gov/29699700" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29699700</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref131">Stasiak
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Karolina, Fleming
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Theresa, Lucassen
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Mathijs F. G, Shepherd
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Matthew J, Whittaker
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Robyn, and Merry
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Sally N (2016) Computer-Based and Online Therapy for Depression and Anxiety in Children and Adolescents. Journal of child and adolescent psychopharmacology
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26(3), 235–45 [<a href="https://pubmed.ncbi.nlm.nih.gov/26465266" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26465266</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref132">Stein
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Ruth E. K, Zitner
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Lauren E, and Jensen
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Peter S (2006) Interventions for adolescent depression in primary care. Pediatrics
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118(2), 669–82 [<a href="https://pubmed.ncbi.nlm.nih.gov/16882822" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16882822</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref133">Straub
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J, Nicolaus
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L, Plener
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Pl, Sprober
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N, and Kolch
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M (2014) Psychotherapeutic treatment of children and adolescents with depression. Review of the literature on cognitive-behavioral and interpersonal group therapies (Provisional abstract). Database of Abstracts of Reviews of Effects (2), 7–15</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref134">Tindall
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Lucy, Mikocka-Walus
|
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Antonina, McMillan
|
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Dean, Wright
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Barry, Hewitt
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Catherine, and Gascoyne
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Samantha (2017) Is behavioural activation effective in the treatment of depression in young people? A systematic review and meta-analysis. Psychology and psychotherapy
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90(4), 770–796 [<a href="/pmc/articles/PMC5697579/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5697579</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28299896" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28299896</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref135">Valimaki
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Maritta, Anttila
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Katriina, Anttila
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Minna, and Lahti
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Mari (2017) Web-Based Interventions Supporting Adolescents and Young People With Depressive Symptoms: Systematic Review and Meta-Analysis. JMIR mHealth and uHealth
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5(12), e180 [<a href="/pmc/articles/PMC5741826/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5741826</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29222079" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29222079</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref136">Verdeli
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H, Mufson
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L, Lee
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L, and Keith
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J A (2006) Review of evidence-based psychotherapies for pediatric mood and anxiety disorders. Current Psychiatry Reviews
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2(3), 395–421</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref137">Wade
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A G (2010) Use of the internet to assist in the treatment of depression and anxiety: A systematic review. Primary Care Companion to the Journal of Clinical Psychiatry
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12(4), e1–e11 [<a href="/pmc/articles/PMC2983464/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2983464</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21085550" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21085550</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref138">Werner-Seidler
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A, Perry
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Y, Calear
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A L, Newby
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J M, and Christensen
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H (2017) School-based depression and anxiety prevention programs for young people: A systematic review and meta-analysis. Clinical Psychology Review
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51, 30–47 [<a href="https://pubmed.ncbi.nlm.nih.gov/27821267" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27821267</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref139">Wu
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Emily, Torous
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John, and Harper
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Gordon (2016) A gap in the literature: Clinical role for smartphone applications for depression care among adolescents?. Journal of the American Academy of Child & Adolescent Psychiatry
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55(7), 630–631 [<a href="https://pubmed.ncbi.nlm.nih.gov/27343892" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27343892</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref140">Yang
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L, Zhou
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X, Zhou
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C, Zhang
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Y, Pu
|
|
J, Liu
|
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L, Gong
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X, and Xie
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P (2017) Efficacy and Acceptability of Cognitive Behavioral Therapy for Depression in Children: A Systematic Review and Meta-analysis.. Academic pediatrics
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17(1), 9–16 [<a href="https://pubmed.ncbi.nlm.nih.gov/27989281" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27989281</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref141">Yatham
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Swetha, Sivathasan
|
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Shalini, Yoon
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Rosalia, da Silva, Tricia L, and Ravindran
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Arun V (2017) Depression, anxiety, and post-traumatic stress disorder among youth in low and middle income countries: A review of prevalence and treatment interventions. Asian journal of psychiatry, [<a href="https://pubmed.ncbi.nlm.nih.gov/29117922" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29117922</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref142">Ye
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|
Xibiao, Bapuji
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Sunita Bayyavarapu, Winters
|
|
Shannon Elizabeth, Struthers
|
|
Ashley, Raynard
|
|
Melissa, Metge
|
|
Colleen, Kreindler
|
|
Sara Adi, Charette
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|
Catherine Joan, Lemaire
|
|
Jacqueline Angela, Synyshyn
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Margaret, and Sutherland
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Karen (2014) Effectiveness of internet-based interventions for children, youth, and young adults with anxiety and/or depression: a systematic review and meta-analysis. BMC health services research
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14, 313 [<a href="/pmc/articles/PMC4110069/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4110069</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25037951" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25037951</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref143">Yuan
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S, Zhou
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X, Zhang
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Y, Zhang
|
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H, Pu
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J, Yang
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L, Liu
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L, Jiang
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X, and Xie
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P (2018) Comparative efficacy and acceptability of bibliotherapy for depression and anxiety disorders in children and adolescents: A meta-analysis of randomized clinical trials. Neuropsychiatric Disease and Treatment
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14, 353–365 [<a href="/pmc/articles/PMC5788928/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5788928</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29416337" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29416337</span></a>]</div></p></li></ul></div><div id="ch2.rl.r1.4"><h5>Excluded studies – RCTs</h5><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref144">Albornoz
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Yadira (2011) The effects of group improvisational music therapy on depression in adolescents and adults with substance abuse: A randomized controlled trial. Nordic Journal of Music Therapy
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|
20(3), 208–224</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref145">Anderson
|
|
Rob, Ukoumunne
|
|
Obioha C, Sayal
|
|
Kapil, Phillips
|
|
Rhiannon, Taylor
|
|
John A, Spears
|
|
Melissa, Araya
|
|
Ricardo, Lewis
|
|
Glyn, Millings
|
|
Abigail, Montgomery
|
|
Alan A, and Stallard
|
|
Paul (2014) Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis. Journal of child psychology and psychiatry, and and allied disciplines
|
|
55(12), 1390–7 [<a href="https://pubmed.ncbi.nlm.nih.gov/24813670" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24813670</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref146">Arnarson
|
|
Eirikur Orn, and Craighead
|
|
W Edward (2009) Prevention of depression among Icelandic adolescents. Behaviour research and therapy
|
|
47(7), 577–85 [<a href="https://pubmed.ncbi.nlm.nih.gov/19411074" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19411074</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref147">Arora
|
|
Prerna G, Baker
|
|
Courtney N, Marchette
|
|
Lauren Krumholz, and Stark
|
|
Kevin D (2017) Components Analyses of a School-Based Cognitive Behavioral Treatment for Youth Depression. Journal of clinical child and adolescent psychology: the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, and Division 53, 1–14 [<a href="/pmc/articles/PMC6131063/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6131063</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28278602" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28278602</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref148">Barry
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Mark, Murphy
|
|
Mike, and O’Donovan
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Hugh (2017) Assessing the effectiveness of a cognitive behavioural group coaching intervention in reducing symptoms of depression among adolescent males in a school setting. International Coaching Psychology Review
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12(2), 101–109</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref149">Bounoua
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N, Abbott
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C, Zisk
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A, Herres
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J, Diamond
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G, and Kobak
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R (2018) Emotion regulation and spillover of interpersonal stressors to postsession insight among depressed and suicidal adolescents. Journal of Consulting and Clinical Psychology
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Satish (2017) Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care: A Randomized Clinical Trial. JAMA psychiatry
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74(6), 571–578 [<a href="/pmc/articles/PMC5539834/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5539834</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28423145" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28423145</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref243">Weersing
|
|
V Robin, Shamseddeen
|
|
Wael, Garber
|
|
Judy, Hollon
|
|
Steven D, Clarke
|
|
Gregory N, Beardslee
|
|
William R, Gladstone
|
|
Tracy R, Lynch
|
|
Frances L, Porta
|
|
Giovanna, Iyengar
|
|
Satish, and Brent
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David A (2016) Prevention of Depression in At-Risk Adolescents: Predictors and Moderators of Acute Effects. Journal of the American Academy of Child and Adolescent Psychiatry
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55(3), 219–26 [<a href="/pmc/articles/PMC4783159/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4783159</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26903255" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26903255</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref244">Whittaker
|
|
Robyn, Stasiak
|
|
Karolina, McDowell
|
|
Heather, Doherty
|
|
Iain, Shepherd
|
|
Matthew, Chua
|
|
Shireen, Dorey
|
|
Enid, Parag
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|
Varsha, Ameratunga
|
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Shanthi, Rodgers
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|
Anthony, and Merry
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Sally (2017) MEMO: an mHealth intervention to prevent the onset of depression in adolescents: a double-blind, randomised, placebo-controlled trial. Journal of child psychology and psychiatry, and and allied disciplines
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58(9), 1014–1022 [<a href="https://pubmed.ncbi.nlm.nih.gov/28573672" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28573672</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref245">Wong
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N, Kady
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L, Mewton
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L, Sunderland
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M, and Andrews
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G (2014) Preventing anxiety and depression in adolescents: A randomised controlled trial of two school based Internet-delivered cognitive behavioural therapy programmes. Internet Interventions
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1(2), 90–94</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref246">Young
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|
Andrea S, Arnold
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|
L Eugene, Wolfson
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|
Hannah L, and Fristad
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|
Mary A (2017) Psychoeducational Psychotherapy and Omega-3 Supplementation Improve Co-Occurring Behavioral Problems in Youth with Depression: Results from a Pilot RCT. Journal of abnormal child psychology
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45(5), 1025–1037 [<a href="/pmc/articles/PMC5342950/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5342950</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27604240" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27604240</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref247">Young
|
|
Andrea S, Meers
|
|
Molly R, Vesco
|
|
Anthony T, Seidenfeld
|
|
Adina M, Arnold
|
|
L Eugene, and Fristad
|
|
Mary A (2016) Predicting Therapeutic Effects of Psychodiagnostic Assessment Among Children and Adolescents Participating in Randomized Controlled Trials. Journal of clinical child and adolescent psychology: the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, and Division 53, 1–12 [<a href="/pmc/articles/PMC5086444/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5086444</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27105332" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27105332</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref248">Young
|
|
J F, Makover
|
|
H B, Cohen
|
|
J R, Mufson
|
|
L, Gallop
|
|
R J, and Benas
|
|
J S (2012) Interpersonal Psychotherapy-Adolescent skills training: Anxiety outcomes and impact of comorbidity. Journal of Clinical Child and Adolescent Psychology
|
|
41(5), 640–653 [<a href="/pmc/articles/PMC3448978/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3448978</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22891881" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22891881</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref249">Young
|
|
Jami F, Kranzler
|
|
Amy, Gallop
|
|
Robert, and Mufson
|
|
Laura (2012) Interpersonal Psychotherapy-Adolescent Skills Training: Effects on School and Social Functioning. School mental health
|
|
4(4), 254–264 [<a href="/pmc/articles/PMC3564646/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3564646</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/23393545" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23393545</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref250">Young
|
|
Jami F, Mufson
|
|
Laura, and Davies
|
|
Mark (2006) Impact of comorbid anxiety in an effectiveness study of interpersonal psychotherapy for depressed adolescents. Journal of the American Academy of Child and Adolescent Psychiatry
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|
45(8), 904–12 [<a href="https://pubmed.ncbi.nlm.nih.gov/16865032" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16865032</span></a>]</div></p></li></ul></div></ul></div><div id="ch2.rl.r2"><h4>Economic studies</h4><ul class="simple-list"><div id="ch2.rl.r2.1"><h5>Included studies</h5><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref251">Byford
|
|
S, Barrett
|
|
B, Roberts
|
|
C
|
|
et al. (2007) Cost-effectiveness of selective serotonin reuptake inhibitors and routine specialist care with and without cognitive behavioural therapy in adolescents with major depression. The British journal of psychiatry: the journal of mental science
|
|
191: 521–7 [<a href="https://pubmed.ncbi.nlm.nih.gov/18055956" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18055956</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref252">Dickerson
|
|
JF, Lynch
|
|
FL, Leo
|
|
Michael C
|
|
et al. (2018) Cost-effectiveness of Cognitive Behavioral Therapy for Depressed Youth Declining Antidepressants. Pediatrics
|
|
141(2) [<a href="/pmc/articles/PMC5810604/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5810604</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29351965" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29351965</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref253">Domino
|
|
ME, Foster
|
|
EM, Vitiello
|
|
B
|
|
et al (2009) Relative cost-effectiveness of treatments for adolescent depression: 36-week results from the TADS Randomised trial. Journal American Academy Child and Adolescent Psychiatry
|
|
48(7): 711–720 [<a href="https://pubmed.ncbi.nlm.nih.gov/19465880" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19465880</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref254">Goodyer
|
|
IM, Reynolds
|
|
S, Barret
|
|
B
|
|
et al. 2017
|
|
Cognitive-behavioural therapy and short-term psychoanalytic psychotherapy versus brief psychological intervention in adolescents with unipolar major depression (IMPACT): a multicentre, pragmatic, observer-blind, randomised controlled trial. Health Technol Assess
|
|
21(12), 1–122 [<a href="/pmc/articles/PMC5392705/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5392705</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28394249" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28394249</span></a>]</div></p></li></ul></div><div id="ch2.rl.r2.2"><h5>Excluded studies</h5><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref255">Anderson
|
|
R, Ukoumunne
|
|
OC, Sayal
|
|
K
|
|
et al. (2014) Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis. Journal of child psychology and psychiatry, and allied disciplines
|
|
55(12): 1390–7 [<a href="https://pubmed.ncbi.nlm.nih.gov/24813670" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24813670</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref256">Arnberg
|
|
FK, Linton
|
|
SJ, Hultcrantz
|
|
M
|
|
et al. (2014) Internet-delivered psychological treatments for mood and anxiety disorders: a systematic review of their efficacy, safety, and cost-effectiveness. PloS one
|
|
9(5): e98118 [<a href="/pmc/articles/PMC4028301/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4028301</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24844847" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24844847</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref257">Bee
|
|
P, Bower
|
|
P, Byford
|
|
S
|
|
et al. (2014) The clinical effectiveness, cost-effectiveness and acceptability of community-based interventions aimed at improving or maintaining quality of life in children of parents with serious mental illness: A systematic review. Health Technology Assessment
|
|
18(8):1–249 [<a href="/pmc/articles/PMC4780907/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4780907</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24502767" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24502767</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref258">Brettschneider
|
|
C, Djadran
|
|
H, Harter
|
|
M
|
|
et al. (2015) Cost-utility analyses of cognitive-behavioural therapy of depression: a systematic review. Psychotherapy and psychosomatics
|
|
84(1): 6–21 [<a href="https://pubmed.ncbi.nlm.nih.gov/25547334" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25547334</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref259">Kuyken
|
|
W, Nuthall
|
|
E, Byford
|
|
S
|
|
et al. (2017) The effectiveness and cost-effectiveness of a mindfulness training programme in schools compared with normal school provision (MYRIAD): study protocol for a randomised controlled trial. Trials
|
|
18(1): 194 [<a href="/pmc/articles/PMC5406917/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5406917</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28446223" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28446223</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref260">Lee
|
|
YY, Barendregt
|
|
JJ, Stockings
|
|
EA
|
|
et al. (2017) The population cost-effectiveness of delivering universal and indicated school-based interventions to prevent the onset of major depression among youth in Australia. Epidemiology and Psychiatric Sciences
|
|
26(5): 545–564 [<a href="/pmc/articles/PMC6998892/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6998892</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27509769" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27509769</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref261">Macdonald
|
|
G, Livingstone
|
|
N, Hanratty
|
|
J
|
|
et al. (2016) The effectiveness, acceptability and cost-effectiveness of psychosocial interventions for maltreated children and adolescents: an evidence synthesis. Health technology assessment (Winchester, and England)
|
|
20(69): 1–508 [<a href="/pmc/articles/PMC5056338/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5056338</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27678342" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27678342</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref262">Philipsson
|
|
A, Duberg
|
|
A, Moller
|
|
M
|
|
et al. (2013) Cost-utility analysis of a dance intervention for adolescent girls with internalizing problems. Cost effectiveness and resource allocation C/E
|
|
11(1): 4 [<a href="/pmc/articles/PMC3598394/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3598394</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/23425608" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23425608</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref263">Rodgers
|
|
M, Asaria
|
|
M, Walker
|
|
S
|
|
et al. (2012) The clinical effectiveness and cost-effectiveness of low-intensity psychological interventions for the secondary prevention of relapse after depression: A systematic review. Health Technology Assessment
|
|
16(28): 1–129 [<a href="/pmc/articles/PMC4781580/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4781580</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22642789" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22642789</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref264">Stafford
|
|
MR, Cooper
|
|
M, Barkham
|
|
M
|
|
et al. (2018) Effectiveness and cost-effectiveness of humanistic counselling in schools for young people with emotional distress (ETHOS): study protocol for a randomised controlled trial. Trials
|
|
19(1): 175 [<a href="/pmc/articles/PMC5845203/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5845203</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29523206" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29523206</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref265">Stallard
|
|
P, Phillips
|
|
R, Montgomery
|
|
AA
|
|
et al. (2013) A cluster randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of classroom-based cognitive-behavioural therapy (CBT) in reducing symptoms of depression in high-risk adolescents. Health technology assessment (Winchester, and England)
|
|
17(47): vii–109 [<a href="/pmc/articles/PMC4781207/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4781207</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24172024" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24172024</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref266">Stikkelbroek
|
|
Y, Bodden
|
|
DH, Dekovic
|
|
M
|
|
et al. (2013) Effectiveness and cost effectiveness of cognitive behavioral therapy (CBT) in clinically depressed adolescents: individual CBT versus treatment as usual (TAU). BMC psychiatry
|
|
13: 314 [<a href="/pmc/articles/PMC4222498/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4222498</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24261913" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24261913</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref267">Wellander
|
|
L, Wells
|
|
MB and Feldman
|
|
Inna (2016) Does Prevention Pay? Costs and Potential Cost-savings of School Interventions Targeting Children with Mental Health Problems. The journal of mental health policy and economics
|
|
19(2): 91–101 [<a href="https://pubmed.ncbi.nlm.nih.gov/27453456" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27453456</span></a>]</div></p></li></ul></div></ul></div><div id="ch2.rl.r2.3"><h4>Additional references</h4><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref268">Dias, Ades, Welton, Jansen and Sutton (2016) Network Meta-Analysis for Decision Making. John Wiley & Sons.</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="ch2.appo.ref269">Hetrick
|
|
SE, McKenzie
|
|
JE, Cox
|
|
GR, Simmons
|
|
MB, Merry
|
|
SN (2012) Newer generation antidepressants for depressive disorders in children and adolescents. Cochrane Database of Systematic Reviews
|
|
2012, Issue 11: CD004851. [<a href="/pmc/articles/PMC8786271/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8786271</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/23152227" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23152227</span></a>]</div></p></li></ul></div></ul></div><div id="ch2.appp"><h3>Appendix P. Scales used to measure continuous outcomes</h3><p>Information about the key scales used in this review are shown in <a class="figpopup" href="/books/NBK557360/table/ch2.appp.tab1/?report=objectonly" target="object" rid-figpopup="figch2appptab1" rid-ob="figobch2appptab1">Table 41</a>. This list is not intended to be exhaustive, but to provide information on some of the main scales reported in the included studies.</p><p id="ch2.appp.tab1"><a href="/books/NBK557360/table/ch2.appp.tab1/?report=objectonly" target="object" rid-ob="figobch2appptab1" class="figpopup">Table 41. Rating scales used in included studies</a></p></div><div id="ch2.appq"><h3>Appendix Q. List of scales with ranking for data extraction</h3><p id="ch2.appq.tab1"><a href="/books/NBK557360/table/ch2.appq.tab1/?report=objectonly" target="object" rid-ob="figobch2appqtab1" class="figpopup">Table 42. <i>List scales used in included studies with ranking for data extraction.</i> Results for depression symptoms were back converted onto the Child Depression Inventory (CDI), the Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA) was used for quality of life and the Children’s Global Assessment Scale (CGAS) was used for level of function</a></p></div><div id="ch2.appr"><h3>Appendix R. NMA models</h3><p>Please refer to <a href="#ch2.apps">appendix S</a> for the inconsistency models.</p><div id="ch2.appr.s1"><h4>Fixed effects model for standardised mean differences with same input and output codes</h4><pre>
|
|
# Normal likelihood, identity link: SMD with arm-based means
|
|
# Fixed effect model
|
|
model{ # *** PROGRAM STARTS
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
for (k in 1:na[i]){
|
|
var[i,k] <- pow(se[i,k],2) # calcultate variances
|
|
prec[i,k] <- 1/var[i,k] # set precisions
|
|
y[i,k] ~ dnorm(phi[i,k], prec[i,k]) # normal likelihood
|
|
#phi[i,k] <- theta[i,k] * Pooled.sd[i] # theta is SMD
|
|
phi[i,k]<- theta[i,k] * sdlist[Scale[i]]
|
|
theta[i,k] <- mu[i] + d[t[i,k]] - d[t[i,1]] # model for linear predictor
|
|
#Deviance contribution
|
|
dev[i,k] <- (y[i,k]-phi[i,k])*(y[i,k]-phi[i,k])/var[i,k]
|
|
}
|
|
# summed residual deviance contribution for this trial
|
|
resdev[i] <- sum(dev[i,1:na[i]])
|
|
}
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
d[1]<-0 # treatment effect is zero for control arm
|
|
# vague priors for treatment effects
|
|
for (k in 2:nt){ d[k] ~ dnorm(0,.0001) }
|
|
for (test in 1:nt)
|
|
{ d2[test] <- d[test] * sdlist[1] }
|
|
|
|
#change sdlist[1] to a specific number if want to back convert onto a different scale
|
|
|
|
# pairwise differences
|
|
for (c in 1:(nt-1))
|
|
{ for (k in (c+1):nt) {
|
|
diff[c,k] <- d2[k] - d2[c]
|
|
}
|
|
}
|
|
# rank treatments
|
|
for (k in 1:nt) {
|
|
rk[k] <- rank(d[],k)
|
|
best[k] <- equals(rk[k],1) # Smallest is best (i.e. rank 1)
|
|
# prob treat k is h-th best, prob[1,k]=best[k]
|
|
for (h in 1:nt) { prob[h,k] <- equals(rk[k],h) }
|
|
}
|
|
}
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.appr.s2"><h4>Random effects model for standardised mean differences with same input and output codes</h4><pre>
|
|
# Normal likelihood, identity link: SMD with arm-based means
|
|
# Random effects model for multi-arm trials
|
|
model{ # *** PROGRAM STARTS
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
w[i,1] <- 0 # adjustment for multi-arm trials is zero for control arm
|
|
delta[i,1] <- 0 # treatment effect is zero for control arm
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
for (k in 1:na[i]){
|
|
var[i,k] <- pow(se[i,k],2) # calcultate variances
|
|
prec[i,k] <- 1/var[i,k] # set precisions
|
|
y[i,k] ~ dnorm(phi[i,k], prec[i,k]) # normal likelihood
|
|
#phi[i,k] <- theta[i,k] * Pooled.sd[i] # theta is SMD
|
|
phi[i,k]<- theta[i,k] * sdlist[Scale[i]]
|
|
theta[i,k] <- mu[i] + delta[i,k] # model for linear predictor
|
|
#Deviance contribution
|
|
dev[i,k] <- (y[i,k]-phi[i,k])*(y[i,k]-phi[i,k])/var[i,k]
|
|
}
|
|
# summed residual deviance contribution for this trial
|
|
resdev[i] <- sum(dev[i,1:na[i]])
|
|
for (k in 2:na[i]){ # LOOP THROUGH ARMS
|
|
# trial-specific RE distributions
|
|
delta[i,k] ~ dnorm(md[i,k], taud[i,k])
|
|
md[i,k] <- d[t[i,k]] - d[t[i,1]] + sw[i,k]
|
|
# precision of RE distributions (with multi-arm trial correction)
|
|
taud[i,k] <- tau *2*(k-1)/k
|
|
#adjustment, multi-arm RCTs
|
|
w[i,k] <- delta[i,k] - d[t[i,k]] + d[t[i,1]]
|
|
# cumulative adjustment for multi-arm trials
|
|
sw[i,k] <-sum(w[i,1:k-1])/(k-1)
|
|
}
|
|
}
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
d[1]<-0 # treatment effect is zero for control arm
|
|
# vague priors for treatment effects
|
|
for (k in 2:nt){ d[k] ~ dnorm(0,.0001) }
|
|
sd ~ dunif(0,10) # vague prior for for between-trial SD
|
|
tau <- pow(sd,-2) # between-trial precision = (1/between-trial variance)
|
|
for (test in 1:nt)
|
|
{ d2[test] <- d[test] * sdlist[1] }
|
|
|
|
#change sdlist[1] to a specific number if want to back convert onto a different scale
|
|
|
|
# pairwise differences
|
|
for (c in 1:(nt-1))
|
|
{ for (k in (c+1):nt) {
|
|
diff[c,k] <- d2[k] - d2[c]
|
|
}
|
|
}
|
|
# rank treatments
|
|
for (k in 1:nt) {
|
|
rk[k] <- rank(d[],k)
|
|
best[k] <- equals(rk[k],1) # Smallest is best (i.e. rank 1)
|
|
# prob treat k is h-th best, prob[1,k]=best[k]
|
|
for (h in 1:nt) { prob[h,k] <- equals(rk[k],h) }
|
|
}
|
|
}
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.appr.s3"><h4>Fixed effects model for standardised mean differences with input and output codes swapped</h4><pre>
|
|
# Input codes 1 and 2 are swopped at output stage.Input 1 had most data, but input 2 was the control.
|
|
|
|
# Normal likelihood, identity link: SMD with arm-based means
|
|
# Fixed effect model
|
|
model{ # *** PROGRAM STARTS
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
for (k in 1:na[i]){
|
|
var[i,k] <- pow(se[i,k],2) # calcultate variances
|
|
prec[i,k] <- 1/var[i,k] # set precisions
|
|
y[i,k] ~ dnorm(phi[i,k], prec[i,k]) # normal likelihood
|
|
#phi[i,k] <- theta[i,k] * Pooled.sd[i] # theta is SMD
|
|
phi[i,k]<- theta[i,k] * sdlist[Scale[i]]
|
|
theta[i,k] <- mu[i] + d[t[i,k]] - d[t[i,1]] # model for linear predictor
|
|
#Deviance contribution
|
|
dev[i,k] <- (y[i,k]-phi[i,k])*(y[i,k]-phi[i,k])/var[i,k]
|
|
}
|
|
# summed residual deviance contribution for this trial
|
|
resdev[i] <- sum(dev[i,1:na[i]])
|
|
}
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
d[1]<-0 # treatment effect is zero for control arm
|
|
# vague priors for treatment effects
|
|
for (k in 2:nt){ d[k] ~ dnorm(0,.0001) }
|
|
for (test in 1:nt)
|
|
{ d2[test] <- d[test] * sdlist[1] }
|
|
|
|
#change sdlist[1] to a specific number if want to back convert onto a different scale
|
|
|
|
# pairwise differences
|
|
for (c in 1:(nt-1))
|
|
{ for (k in (c+1):nt)
|
|
{ diff[c,k] <- d2[k] - d2[c]
|
|
}
|
|
}
|
|
diff2[1,2] <- -diff[1,2]
|
|
for (test in 3:nt)
|
|
{
|
|
diff2[1,test]<-diff[2,test]
|
|
}
|
|
for (test in 3:nt)
|
|
{
|
|
diff2[2,test]<-diff[1,test]
|
|
}
|
|
|
|
for (c in 3:(nt-1))
|
|
{ for (k in (c+1):nt)
|
|
{ diff2[c,k] <- diff[c,k]
|
|
}
|
|
}
|
|
d3[1]<-0
|
|
d3[2]<- -diff[1,2]
|
|
for (test in 3:nt)
|
|
{ d3[test] <- diff[2,test] }
|
|
# rank treatments
|
|
for (k in 1:nt) {
|
|
rk[k] <- rank(d3[],k)
|
|
best[k] <- equals(rk[k],1) # Smallest is best (i.e. rank 1)
|
|
# prob treat k is h-th best, prob[1,k]=best[k]
|
|
for (h in 1:nt) { prob[h,k] <- equals(rk[k],h) }
|
|
}
|
|
}
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.appr.s4"><h4>Random effects model for standardised mean differences with input and output codes swapped</h4><pre>
|
|
# Input codes 1 and 2 are swopped at output stage.Input 1 had most data, but input 2 was the control.
|
|
|
|
# Normal likelihood, identity link: SMD with arm-based means
|
|
# Random effects model for multi-arm trials
|
|
model{ # *** PROGRAM STARTS
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
w[i,1] <- 0 # adjustment for multi-arm trials is zero for control arm
|
|
delta[i,1] <- 0 # treatment effect is zero for control arm
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
for (k in 1:na[i]){
|
|
var[i,k] <- pow(se[i,k],2) # calcultate variances
|
|
prec[i,k] <- 1/var[i,k] # set precisions
|
|
y[i,k] ~ dnorm(phi[i,k], prec[i,k]) # normal likelihood
|
|
#phi[i,k] <- theta[i,k] * Pooled.sd[i] # theta is SMD
|
|
phi[i,k]<- theta[i,k] * sdlist[Scale[i]]
|
|
theta[i,k] <- mu[i] + delta[i,k] # model for linear predictor
|
|
#Deviance contribution
|
|
dev[i,k] <- (y[i,k]-phi[i,k])*(y[i,k]-phi[i,k])/var[i,k]
|
|
}
|
|
# summed residual deviance contribution for this trial
|
|
resdev[i] <- sum(dev[i,1:na[i]])
|
|
for (k in 2:na[i]){ # LOOP THROUGH ARMS
|
|
# trial-specific RE distributions
|
|
delta[i,k] ~ dnorm(md[i,k], taud[i,k])
|
|
md[i,k] <- d[t[i,k]] - d[t[i,1]] + sw[i,k]
|
|
# precision of RE distributions (with multi-arm trial correction)
|
|
taud[i,k] <- tau *2*(k-1)/k
|
|
#adjustment, multi-arm RCTs
|
|
w[i,k] <- delta[i,k] - d[t[i,k]] + d[t[i,1]]
|
|
# cumulative adjustment for multi-arm trials
|
|
sw[i,k] <-sum(w[i,1:k-1])/(k-1)
|
|
}
|
|
}
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
d[1]<-0 # treatment effect is zero for control arm
|
|
# vague priors for treatment effects
|
|
for (k in 2:nt){ d[k] ~ dnorm(0,.0001) }
|
|
sd ~ dunif(0,10) # vague prior for for between-trial SD
|
|
tau <- pow(sd,-2) # between-trial precision = (1/between-trial variance)
|
|
for (test in 1:nt)
|
|
{ d2[test] <- d[test] * sdlist[1] }
|
|
|
|
#change sdlist[1] to a specific number if want to back convert onto a different scale
|
|
|
|
# pairwise differences
|
|
for (c in 1:(nt-1))
|
|
{ for (k in (c+1):nt)
|
|
{ diff[c,k] <- d2[k] - d2[c]
|
|
}
|
|
}
|
|
diff2[1,2] <- -diff[1,2]
|
|
for (test in 3:nt)
|
|
{
|
|
diff2[1,test]<-diff[2,test]
|
|
}
|
|
for (test in 3:nt)
|
|
{
|
|
diff2[2,test]<-diff[1,test]
|
|
}
|
|
|
|
for (c in 3:(nt-1))
|
|
{ for (k in (c+1):nt)
|
|
{ diff2[c,k] <- diff[c,k]
|
|
}
|
|
}
|
|
d3[1]<-0
|
|
d3[2]<- -diff[1,2]
|
|
for (test in 3:nt)
|
|
{ d3[test] <- diff[2,test] }
|
|
# rank treatments
|
|
for (k in 1:nt) {
|
|
rk[k] <- rank(d3[],k)
|
|
best[k] <- equals(rk[k],1) # Smallest is best (i.e. rank 1)
|
|
# prob treat k is h-th best, prob[1,k]=best[k]
|
|
for (h in 1:nt) { prob[h,k] <- equals(rk[k],h) }
|
|
}
|
|
}
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.appr.s5"><h4>Fixed effects model for relative risk with same input and output codes</h4><pre>
|
|
model{ # *** PROGRAM STARTS
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
for (k in 1:na[i]) { # LOOP THROUGH ARMS 62
|
|
r[i,k] ~ dbin(p[i,k],n[i,k]) # binomial likelihood
|
|
logit(p[i,k]) <- mu[i] + d[t[i,k]] - d[t[i,1]] # model for linear predictor
|
|
rhat[i,k] <- p[i,k] * n[i,k] # expected value of the numerators
|
|
dev[i,k] <- 2 * (r[i,k] * (log(r[i,k])-log(rhat[i,k])) #Deviance contribution
|
|
+ (n[i,k]-r[i,k]) * (log(n[i,k]-r[i,k]) - log(n[i,k]-rhat[i,k])))
|
|
}
|
|
resdev[i] <- sum(dev[i,1:na[i]]) # summed residual deviance contribution for this trial
|
|
}
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
d[1]<-0 # treatment effect is zero for reference treatment
|
|
for (k in 2:nt){ d[k] ~ dnorm(0,.0001) } # vague priors for treatment effects
|
|
for (l in 1:nt) { pbest[l]<-equals(rank(d[],l),5) }
|
|
for (z in 1:(nt-1))
|
|
{
|
|
caterpillar[z] <- exp(d[z+1])-d[1]
|
|
}
|
|
# pairwise ORs and LORs for all possible pair-wise comparisons, if nt>2
|
|
for (c in 1:(nt-1)) {
|
|
for (k in (c+1):nt) {
|
|
or[c,k] <- exp(d[k] - d[c])
|
|
lor[c,k] <- (d[k]-d[c])
|
|
}
|
|
}
|
|
# change distribution A below for each outcome of interest (data taken from events in treatment 1 for the largest trial)
|
|
A ~ dnorm(-1.098612289, 2.25)
|
|
|
|
for (k in 1:nt) { logit(T[k]) <- A + d[k] }
|
|
# Provide estimates of number needed to treat NNT[k], Risk Difference RD[k],
|
|
# and Relative Risk RR[k], for each treatment, relative to treatment 1
|
|
RR[1] <- 1
|
|
for (k in 2:nt) {
|
|
RR[k] <- T[k]/T[1]
|
|
}
|
|
for (c in 1:(nt-1)) {
|
|
for (k in (c+1):nt) {
|
|
RRR[c,k] <- T[k]/T[c]
|
|
}
|
|
}
|
|
# rank treatments
|
|
for (k in 1:nt) {
|
|
rk[k] <- rank(d[],k)
|
|
best[k] <- equals(rk[k],1) # Smallest is best (i.e. rank 1)
|
|
# prob treat k is h-th best, prob[1,k]=best[k]
|
|
for (h in 1:nt) { prob[h,k] <- equals(rk[k],h) }
|
|
}
|
|
}
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.appr.s6"><h4>Random effects model for relative risk with same input and output codes</h4><pre>
|
|
model{ # *** PROGRAM STARTS
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
w[i,1] <- 0 # adjustment for multi-arm trials is zero for control arm
|
|
delta[i,1] <- 0 # treatment effect is zero for control arm
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
for (k in 1:na[i]) { # LOOP THROUGH ARMS
|
|
r[i,k] ~ dbin(p[i,k],n[i,k]) # binomial likelihood
|
|
logit(p[i,k]) <- mu[i] + delta[i,k] # model for linear predictor
|
|
rhat[i,k] <- p[i,k] * n[i,k] # expected value of the numerators
|
|
dev[i,k] <- 2 * (r[i,k] * (log(r[i,k])-log(rhat[i,k])) #Deviance contribution
|
|
+ (n[i,k]-r[i,k]) * (log(n[i,k]-r[i,k]) - log(n[i,k]-rhat[i,k])))
|
|
}
|
|
resdev[i] <- sum(dev[i,1:na[i]]) # summed residual deviance contribution for this trial
|
|
for (k in 2:na[i]) { # LOOP THROUGH ARMS
|
|
delta[i,k] ~ dnorm(md[i,k],taud[i,k]) # trial-specific LOR distributions
|
|
md[i,k] <- d[t[i,k]] - d[t[i,1]] + sw[i,k] # mean of LOR distributions (with multi-arm trial correction)
|
|
taud[i,k] <- tau *2*(k-1)/k # precision of LOR distributions (with multi-arm trial correction)
|
|
w[i,k] <- (delta[i,k] - d[t[i,k]] + d[t[i,1]]) # adjustment for multi-arm RCTs
|
|
sw[i,k] <- sum(w[i,1:k-1])/(k-1) # cumulative adjustment for multi-arm trials
|
|
}
|
|
}
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
d[1] <- 0 # treatment effect is zero for reference treatment
|
|
for (k in 2:nt){ d[k] ~ dnorm(0,.0001) } # vague priors for treatment effects
|
|
sd ~ dunif(0,5) # vague prior for between-trial SD. ALTERNATIVES BELOW
|
|
tau <- pow(sd,-2) # between-trial precision = (1/between-trial variance)
|
|
# pairwise ORs and LORs for all possible pair-wise comparisons, if nt>2
|
|
for (c in 1:(nt-1)) {
|
|
for (k in (c+1):nt) {
|
|
or[c,k] <- exp(d[k] - d[c])
|
|
lor[c,k] <- (d[k]-d[c])
|
|
}
|
|
}
|
|
# change distribution A below for each outcome of interest (data taken from events in treatment 1 for the largest trial)
|
|
A ~ dnorm(-1.098612289, 2.25)
|
|
|
|
for (k in 1:nt) { logit(T[k]) <- A + d[k] }
|
|
# Provide estimates of number needed to treat NNT[k], Risk Difference RD[k],
|
|
# and Relative Risk RR[k], for each treatment, relative to treatment 1
|
|
RR[1] <- 1
|
|
for (k in 2:nt) {
|
|
RR[k] <- T[k]/T[1]
|
|
}
|
|
for (c in 1:(nt-1)) {
|
|
for (k in (c+1):nt) {
|
|
RRR[c,k] <- T[k]/T[c]
|
|
}
|
|
}
|
|
# rank treatments
|
|
for (k in 1:nt) {
|
|
rk[k] <- rank(d[],k)
|
|
best[k] <- equals(rk[k],1) # Smallest is best (i.e. rank 1)
|
|
# prob treat k is h-th best, prob[1,k]=best[k]
|
|
for (h in 1:nt) { prob[h,k] <- equals(rk[k],h) }
|
|
}
|
|
}
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.appr.s7"><h4>Fixed effects model for relative risk with input and output codes swapped</h4><pre>
|
|
# Input codes 1 and 2 are swopped at output stage.Input 1 had most data, but input 2 was the control.
|
|
|
|
model{ # *** PROGRAM STARTS
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
for (k in 1:na[i]) { # LOOP THROUGH ARMS 62- can do > 2 arms
|
|
r[i,k] ~ dbin(p[i,k],n[i,k]) # binomial likelihood
|
|
logit(p[i,k]) <- mu[i] + d[t[i,k]] - d[t[i,1]] # model for linear predictor
|
|
rhat[i,k] <- p[i,k] * n[i,k] # expected value of the numerators
|
|
dev[i,k] <- 2 * (r[i,k] * (log(r[i,k])-log(rhat[i,k])) #Deviance contribution
|
|
+ (n[i,k]-r[i,k]) * (log(n[i,k]-r[i,k]) - log(n[i,k]-rhat[i,k])))
|
|
}
|
|
resdev[i] <- sum(dev[i,1:na[i]]) # summed residual deviance contribution for this trial
|
|
}
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
d[1]<-0 # treatment effect is zero for reference treatment
|
|
for (k in 2:nt){ d[k] ~ dnorm(0,.0001) } # vague priors for treatment effects
|
|
for (l in 1:nt) { pbest[l]<-equals(rank(d[],l),5) }
|
|
for (z in 1:(nt-1))
|
|
{
|
|
caterpillar[z] <- exp(d[z+1])-d[1]
|
|
}
|
|
# pairwise ORs and LORs for all possible pair-wise comparisons, if nt>2
|
|
for (c in 1:(nt-1)) {
|
|
for (k in (c+1):nt) {
|
|
or[c,k] <- exp(d[k] - d[c])
|
|
lor[c,k] <- (d[k]-d[c])
|
|
}
|
|
}
|
|
for (c in 1:(nt-1))
|
|
{ for (k in (c+1):nt)
|
|
{ diff[c,k] <- d[k] - d[c]
|
|
}
|
|
}
|
|
diff2[1,2] <- -diff[1,2]
|
|
for (test in 3:nt)
|
|
{
|
|
diff2[1,test]<-diff[2,test]
|
|
}
|
|
for (test in 3:nt)
|
|
{
|
|
diff2[2,test]<-diff[1,test]
|
|
}
|
|
|
|
for (c in 3:(nt-1))
|
|
{ for (k in (c+1):nt)
|
|
{ diff2[c,k] <- diff[c,k]
|
|
}
|
|
}
|
|
d3[1]<-0
|
|
d3[2]<- -diff[1,2]
|
|
for (test in 3:nt)
|
|
{ d3[test] <- diff[2,test] }
|
|
|
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# change distribution A below for each outcome of interest (data taken from events in treatment 1 for the largest trial)
|
|
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A ~ dnorm( 0.555946059, 24.78504673)
|
|
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for (k in 1:nt) { logit(T[k]) <- A + d3[k] }
|
|
# Provide estimates of number needed to treat NNT[k], Risk Difference RD[k],
|
|
# and Relative Risk RR[k], for each treatment, relative to treatment 1
|
|
RR[1] <- 1
|
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for (k in 2:nt) {
|
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RR[k] <- T[k]/T[1]
|
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}
|
|
for (c in 1:(nt-1)) {
|
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for (k in (c+1):nt) {
|
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RRR[c,k] <- T[k]/T[c]
|
|
}
|
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}
|
|
# rank treatments
|
|
for (k in 1:nt) {
|
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rk[k] <- rank(d3[],k)
|
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best[k] <- equals(rk[k],1) # Smallest is best (i.e. rank 1)
|
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# prob treat k is h-th best, prob[1,k]=best[k]
|
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for (h in 1:nt) { prob[h,k] <- equals(rk[k],h) }
|
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}
|
|
}
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.appr.s8"><h4>Random effects model for relative risk with input and ouput codes swapped</h4><pre>
|
|
# Input codes 1 and 2 are swopped at output stage.Input 1 had most data, but input 2 was the control.
|
|
|
|
model{ # *** PROGRAM STARTS
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
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w[i,1] <- 0 # adjustment for multi-arm trials is zero for control arm
|
|
delta[i,1] <- 0 # treatment effect is zero for control arm
|
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mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
for (k in 1:na[i]) { # LOOP THROUGH ARMS
|
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r[i,k] ~ dbin(p[i,k],n[i,k]) # binomial likelihood
|
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logit(p[i,k]) <- mu[i] + delta[i,k] # model for linear predictor
|
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rhat[i,k] <- p[i,k] * n[i,k] # expected value of the numerators
|
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dev[i,k] <- 2 * (r[i,k] * (log(r[i,k])-log(rhat[i,k])) #Deviance contribution
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+ (n[i,k]-r[i,k]) * (log(n[i,k]-r[i,k]) - log(n[i,k]-rhat[i,k])))
|
|
}
|
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resdev[i] <- sum(dev[i,1:na[i]]) # summed residual deviance contribution for this trial
|
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for (k in 2:na[i]) { # LOOP THROUGH ARMS
|
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delta[i,k] ~ dnorm(md[i,k],taud[i,k]) # trial-specific LOR distributions
|
|
md[i,k] <- d[t[i,k]] - d[t[i,1]] + sw[i,k] # mean of LOR distributions (with multi-arm trial correction)
|
|
taud[i,k] <- tau *2*(k-1)/k # precision of LOR distributions (with multi-arm trial correction)
|
|
w[i,k] <- (delta[i,k] - d[t[i,k]] + d[t[i,1]]) # adjustment for multi-arm RCTs
|
|
sw[i,k] <- sum(w[i,1:k-1])/(k-1) # cumulative adjustment for multi-arm trials
|
|
}
|
|
}
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
d[1] <- 0 # treatment effect is zero for reference treatment
|
|
for (k in 2:nt){ d[k] ~ dnorm(0,.0001) } # vague priors for treatment effects
|
|
sd ~ dunif(0,5) # vague prior for between-trial SD. ALTERNATIVES BELOW
|
|
tau <- pow(sd,-2) # between-trial precision = (1/between-trial variance)
|
|
# pairwise ORs and LORs for all possible pair-wise comparisons, if nt>2
|
|
for (c in 1:(nt-1)) {
|
|
for (k in (c+1):nt) {
|
|
or[c,k] <- exp(d[k] - d[c])
|
|
lor[c,k] <- (d[k]-d[c])
|
|
}
|
|
}
|
|
for (c in 1:(nt-1))
|
|
{ for (k in (c+1):nt)
|
|
{ diff[c,k] <- d[k] - d[c]
|
|
}
|
|
}
|
|
diff2[1,2] <- -diff[1,2]
|
|
for (test in 3:nt)
|
|
{
|
|
diff2[1,test]<-diff[2,test]
|
|
}
|
|
for (test in 3:nt)
|
|
{
|
|
diff2[2,test]<-diff[1,test]
|
|
}
|
|
for (c in 3:(nt-1))
|
|
{ for (k in (c+1):nt)
|
|
{ diff2[c,k] <- diff[c,k]
|
|
}
|
|
}
|
|
d3[1]<-0
|
|
d3[2]<- -diff[1,2]
|
|
for (test in 3:nt)
|
|
{ d3[test] <- diff[2,test] }
|
|
|
|
# change distribution A below for each outcome of interest (data taken from events in treatment 1 for the largest trial)
|
|
|
|
A ~ dnorm( 0.555946059, 24.78504673)
|
|
for (k in 1:nt) { logit(T[k]) <- A + d3[k] }
|
|
# Provide estimates of number needed to treat NNT[k], Risk Difference RD[k],
|
|
# and Relative Risk RR[k], for each treatment, relative to treatment 1
|
|
RR[1] <- 1
|
|
for (k in 2:nt) {
|
|
RR[k] <- T[k]/T[1]
|
|
}
|
|
for (c in 1:(nt-1)) {
|
|
for (k in (c+1):nt) {
|
|
RRR[c,k] <- T[k]/T[c]
|
|
}
|
|
}
|
|
# rank treatments
|
|
for (k in 1:nt) {
|
|
rk[k] <- rank(d3[],k)
|
|
best[k] <- equals(rk[k],1) # Smallest is best (i.e. rank 1)
|
|
# prob treat k is h-th best, prob[1,k]=best[k]
|
|
for (h in 1:nt) { prob[h,k] <- equals(rk[k],h) }
|
|
}
|
|
}
|
|
} # *** PROGRAM ENDS
|
|
</pre></div></div><div id="ch2.apps"><h3>Appendix S. Checking for inconsistency in the NMA results</h3><div id="ch2.apps.s1"><h4>Introduction</h4><p>The purpose of this analysis was to assess the consistency assumption in the network meta-analysis (NMA) models used to estimate the comparative effectiveness of psychological interventions for treating depression in children and young people.</p></div><div id="ch2.apps.s2"><h4>Methods</h4><p>An important assumption made in NMA concerns the consistency, that is, the agreement of the direct and indirect evidence informing the treatment contrasts [<a class="bibr" href="#ch2.apps.ref1" rid="ch2.apps.ref1">1</a>,<a class="bibr" href="#ch2.apps.ref2" rid="ch2.apps.ref2">2</a>]. There should be no meaningful differences between these two sources of evidence.</p><p>To determine if there is evidence of inconsistency, the selected consistency model (fixed or random effects) was compared to an “inconsistency”, or unrelated mean effects, model [<a class="bibr" href="#ch2.apps.ref1" rid="ch2.apps.ref1">1</a>,<a class="bibr" href="#ch2.apps.ref2" rid="ch2.apps.ref2">2</a>]. The latter is equivalent to having separate, unrelated, meta-analyses for every pairwise contrast, with a common variance parameter assumed in the case of random effects models. Note that the consistency assumption can only be assessed when there are closed loops of direct evidence on 3 treatments that are informed by at least 3 independent sources of evidence [<a class="bibr" href="#ch2.apps.ref3" rid="ch2.apps.ref3">3</a>]. This was not the case for the networks of evidence listed in <a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab1/?report=objectonly" target="object" rid-figpopup="figch2appstab1" rid-ob="figobch2appstab1">Table 43</a>.</p><p id="ch2.apps.tab1"><a href="/books/NBK557360/table/ch2.apps.tab1/?report=objectonly" target="object" rid-ob="figobch2appstab1" class="figpopup">Table 43. Networks where inconsistency checks were not possible</a></p><p>The posterior mean of the residual deviance, which measures the magnitude of the differences between the observed data and the model predictions of the data, was used to assess and compare the goodness of fit of each model [<a class="bibr" href="#ch2.apps.ref4" rid="ch2.apps.ref4">4</a>]. Smaller values are preferred, and in a well-fitting model the posterior mean residual deviance should be close to the number of data points in the network (each study arm contributes 1 data point) [<a class="bibr" href="#ch2.apps.ref4" rid="ch2.apps.ref4">4</a>].</p><p>In addition to assessing how well the models fit the data using the posterior mean of the residual deviance, models were compared using the deviance information criterion (DIC). This is equal to the sum of the posterior mean deviance and the effective number of parameters, and thus penalizes model fit with model complexity [<a class="bibr" href="#ch2.apps.ref4" rid="ch2.apps.ref4">4</a>]. Lower values are preferred and differences of 3 points were considered meaningful [<a class="bibr" href="#ch2.apps.ref4" rid="ch2.apps.ref4">4</a>].</p><p>The posterior median between-study standard deviation, which measures the heterogeneity of treatment effects estimated by trials making the same treatment comparisons, was also used to compare models. If the inconsistency model has smaller heterogeneity compared to the consistency model, then this indicates potential inconsistency in the data.</p><p><b>NOTE</b>: These inconsistency checks were carried out on earlier versions of the analyses which included: <a class="bibr" href="#ch2.appo.ref201" rid="ch2.appo.ref201">Luby (2012)</a> for 5–11 year olds with moderate to severe depression; <a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy (2007)</a> for mild depression in 12–18 year olds and <a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy (2014)</a> and <a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel (2016)</a> for moderate to severe depression in 12–18 year olds. However, the inconsistency analyses were not rerun because the removal of studies is expected to decrease inconsistency where any was previously detected. In the case of <a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel (2016)</a>, the removal of this paper led to the loss of IPT-A with extra parent sessions from the NMA network. <a class="bibr" href="#ch2.appo.ref201" rid="ch2.appo.ref201">Luby (2012)</a> was completely excluded from the review because the study recruited children aged 3–7 years old and this update covers 5–18 year olds only. <a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy (2007</a> and <a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">2014</a>) were excluded because they recruited young people with depression and a specific comorbidity. In addition, for 5–11 year olds with moderate to severe depression, the interventions in <a class="bibr" href="#ch2.appo.ref18" rid="ch2.appo.ref18">Dietz (2015)</a> and <a class="bibr" href="#ch2.appo.ref24" rid="ch2.appo.ref24">Fristad (2016)</a> were reclassified from family therapy to family based IPT and family psychoeducation with CBT respectively. Family psychoeducation with CBT (<a class="bibr" href="#ch2.appo.ref24" rid="ch2.appo.ref24">Fristad, 2016</a>) was not included in the updated analyses due to the lack of a connection to the network.</p></div><div id="ch2.apps.s3"><h4>Results</h4><div id="ch2.apps.s3.1"><h5>3.1. Outcome: Depression Symptoms Post-Treatment, 12 – 18 Year Olds, Mild Depression</h5><p>Inconsistency checks were performed using the random effects model, as smaller posterior mean residual deviance and DIC suggests this model was preferred over the fixed effect model. Convergence was satisfactory for the random effects model assuming inconsistency after 20,000 iterations, and the consistency and inconsistency models were compared using results based on samples from a further 40,000 iterations on two chains. WinBUGS code for the inconsistency model is provided in <a href="#ch2.apps.s5">appendix S1</a>.</p><p>There are no meaningful differences between the fit of the random effects consistency and inconsistency models (<a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab2/?report=objectonly" target="object" rid-figpopup="figch2appstab2" rid-ob="figobch2appstab2">Table 44</a>). However, the between-study standard deviation is smaller in the inconsistency model. The area below the line of equality in <a class="figpopup" href="/books/NBK557360/figure/ch2.apps.fig1/?report=objectonly" target="object" rid-figpopup="figch2appsfig1" rid-ob="figobch2appsfig1">Figure 121</a> highlights where the inconsistency model better predicted data points, and there were notable improvements in the prediction of data in <a class="bibr" href="#ch2.appo.ref34" rid="ch2.appo.ref34">Jacob 2016</a>, <a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>, and <a class="bibr" href="#ch2.appo.ref2" rid="ch2.appo.ref2">Ackerson 1998</a>.</p><p id="ch2.apps.tab2"><a href="/books/NBK557360/table/ch2.apps.tab2/?report=objectonly" target="object" rid-ob="figobch2appstab2" class="figpopup">Table 44. Model fit statistics for ‘Depression symptoms, post-treatment’, 12 to 18 year olds with mild depression</a></p><p id="ch2.apps.fig1"><a href="/books/NBK557360/figure/ch2.apps.fig1/?report=objectonly" target="object" rid-ob="figobch2appsfig1" class="figpopup">Figure 121. Deviance contributions for the random effects consistency and inconsistency models</a></p></div><div id="ch2.apps.s3.2"><h5>3.2. Outcome: Depression Symptoms Post-Treatment, 12 – 18 Year Olds, Moderate to Severe Depression</h5><p>Inconsistency checks were performed using the random effects model, as smaller posterior mean residual deviance and DIC suggests this model was preferred over the fixed effect model. Convergence was satisfactory for the random effects model assuming inconsistency after 20,000 iterations, and the consistency and inconsistency models were compared using results based on samples from a further 40,000 iterations on two chains. WinBUGS code for the inconsistency model is provided in <a href="#ch2.apps.s5">appendix S1</a>.</p><p>There are no meaningful differences between the fit of the random effects consistency and inconsistency models, and the between-study standard deviation is smaller in the consistency model (<a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab3/?report=objectonly" target="object" rid-figpopup="figch2appstab3" rid-ob="figobch2appstab3">Table 45</a>). The area below the line of equality in <a class="figpopup" href="/books/NBK557360/figure/ch2.apps.fig2/?report=objectonly" target="object" rid-figpopup="figch2appsfig2" rid-ob="figobch2appsfig2">Figure 122</a> highlights where the inconsistency model better predicted data points, and the improvements were minimal.</p><p id="ch2.apps.tab3"><a href="/books/NBK557360/table/ch2.apps.tab3/?report=objectonly" target="object" rid-ob="figobch2appstab3" class="figpopup">Table 45. Model fit statistics for ‘Depression symptoms, post-treatment’, 12 to 18 year olds with moderate to severe depression</a></p><p id="ch2.apps.fig2"><a href="/books/NBK557360/figure/ch2.apps.fig2/?report=objectonly" target="object" rid-ob="figobch2appsfig2" class="figpopup">Figure 122. Deviance contributions for the random effects consistency and inconsistency models</a></p></div><div id="ch2.apps.s3.3"><h5>3.3. Outcome: Depression Symptoms at Follow-Up up to 6 Months, 12 – 18 Year Olds, Mild Depression</h5><p>Inconsistency checks were performed using the fixed effect model, as there were no meaningful differences in the DIC. Nevertheless, the model fit was poor, since the posterior total residual deviance is notably larger than the number of data points (<a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab4/?report=objectonly" target="object" rid-figpopup="figch2appstab4" rid-ob="figobch2appstab4">Table 46</a>). Convergence was satisfactory for the fixed effect model assuming inconsistency after 20,000 iterations, and the consistency and inconsistency models were compared using results based on samples from a further 40,000 iterations on two chains. WinBUGS code for the inconsistency model is provided in <a href="#ch2.apps.s6">appendix S2</a>.</p><p>There are no meaningful differences between the fit of the fixed effect consistency and inconsistency models (<a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab4/?report=objectonly" target="object" rid-figpopup="figch2appstab4" rid-ob="figobch2appstab4">Table 46</a>). The area below the line of equality in <a class="figpopup" href="/books/NBK557360/figure/ch2.apps.fig3/?report=objectonly" target="object" rid-figpopup="figch2appsfig3" rid-ob="figobch2appsfig3">Figure 123</a> highlights where the inconsistency model better predicted data points, and there were notable improvements in the prediction of data in <a class="bibr" href="#ch2.appo.ref30" rid="ch2.appo.ref30">Hayes 2011</a>.</p><p id="ch2.apps.tab4"><a href="/books/NBK557360/table/ch2.apps.tab4/?report=objectonly" target="object" rid-ob="figobch2appstab4" class="figpopup">Table 46. Model fit statistics for ‘Depression symptoms, ≤ 6 months’, 12 to 18 year olds with mild depression</a></p><p id="ch2.apps.fig3"><a href="/books/NBK557360/figure/ch2.apps.fig3/?report=objectonly" target="object" rid-ob="figobch2appsfig3" class="figpopup">Figure 123. Deviance contributions for the fixed effect consistency and inconsistency models</a></p></div><div id="ch2.apps.s3.4"><h5>3.4. Outcome: Functional Status, >6 to ≤ 18 Months, 12 – 18 Year Olds, Mild Depression</h5><p>Inconsistency checks were performed using the fixed effect model, as there were no meaningful differences in the posterior mean residual deviance or DIC. Convergence was satisfactory for the fixed effect model assuming inconsistency after 20,000 iterations, and the consistency and inconsistency models were compared using results based on samples from a further 40,000 iterations on two chains. WinBUGS code for the inconsistency model is provided in <a href="#ch2.apps.s6">appendix S2</a>.</p><p>There are no meaningful differences between the fit of the fixed effect consistency and inconsistency models (<a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab5/?report=objectonly" target="object" rid-figpopup="figch2appstab5" rid-ob="figobch2appstab5">Table 47</a>). The area below the line of equality in <a class="figpopup" href="/books/NBK557360/figure/ch2.apps.fig4/?report=objectonly" target="object" rid-figpopup="figch2appsfig4" rid-ob="figobch2appsfig4">Figure 124</a> highlights where the inconsistency model better predicted data points, and there were no improvements.</p><p id="ch2.apps.tab5"><a href="/books/NBK557360/table/ch2.apps.tab5/?report=objectonly" target="object" rid-ob="figobch2appstab5" class="figpopup">Table 47. Model fit statistics for ‘Functional status >6 to ≤ 18 months’, 12 to 18 year olds with mild depression</a></p><p id="ch2.apps.fig4"><a href="/books/NBK557360/figure/ch2.apps.fig4/?report=objectonly" target="object" rid-ob="figobch2appsfig4" class="figpopup">Figure 124. Deviance contributions for the fixed effect consistency and inconsistency models</a></p></div><div id="ch2.apps.s3.5"><h5>3.5. Outcome: Discontinuation, Endpoint, 12 – 18 Year Olds, Mild Depression</h5><p>Inconsistency checks were performed using the random effects model, as smaller posterior mean residual deviance and DIC suggests this model was preferred over the fixed effect model. Nevertheless, the model fit was poor, since the posterior total residual deviance is notably larger than the number of data points (<a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab6/?report=objectonly" target="object" rid-figpopup="figch2appstab6" rid-ob="figobch2appstab6">Table 48</a>). Convergence was satisfactory for the random effects model assuming inconsistency after 20,000 iterations, and the consistency and inconsistency models were compared using results based on samples from a further 40,000 iterations on two chains. WinBUGS code for the inconsistency model is provided in <a href="#ch2.apps.s7">appendix S3</a>.</p><p>The inconsistency model better fitted the data, as noted by the smaller posterior mean residual deviance and DIC (<a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab6/?report=objectonly" target="object" rid-figpopup="figch2appstab6" rid-ob="figobch2appstab6">Table 48</a>). The area below the line of equality in <a class="figpopup" href="/books/NBK557360/figure/ch2.apps.fig5/?report=objectonly" target="object" rid-figpopup="figch2appsfig5" rid-ob="figobch2appsfig5">Figure 125</a> highlights where the inconsistency model better predicted data points, and there were notable improvements in the prediction of data in <a class="bibr" href="#ch2.appo.ref60" rid="ch2.appo.ref60">Smith 2015</a>, <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppleaars 2016</a>, and <a class="bibr" href="#ch2.appo.ref20" rid="ch2.appo.ref20">Duong 2016</a>.</p><p id="ch2.apps.tab6"><a href="/books/NBK557360/table/ch2.apps.tab6/?report=objectonly" target="object" rid-ob="figobch2appstab6" class="figpopup">Table 48. Model fit statistics for ‘Discontinuation for any reason, end point’, 12 to 18 year olds with mild depression</a></p><p id="ch2.apps.fig5"><a href="/books/NBK557360/figure/ch2.apps.fig5/?report=objectonly" target="object" rid-ob="figobch2appsfig5" class="figpopup">Figure 125. Deviance contributions for the random effects consistency and inconsistency models</a></p></div><div id="ch2.apps.s3.6"><h5>3.6. Outcome: Discontinuation, Endpoint, 12 – 18 Year Olds, Moderate to Severe Depression</h5><p>Inconsistency checks were performed using the fixed effect model, as there were no meaningful differences in the posterior mean residual deviance or DIC. Convergence was satisfactory for the fixed effect model assuming inconsistency after 20,000 iterations, and the consistency and inconsistency models were compared using results based on samples from a further 40,000 iterations on two chains. WinBUGS code for the inconsistency model is provided in <a href="#ch2.apps.s8">appendix S4</a>.</p><p>There are no meaningful differences between the fit of the fixed effect consistency and inconsistency models (<a class="figpopup" href="/books/NBK557360/table/ch2.apps.tab7/?report=objectonly" target="object" rid-figpopup="figch2appstab7" rid-ob="figobch2appstab7">Table 49</a>). The area below the line of equality in <a class="figpopup" href="/books/NBK557360/figure/ch2.apps.fig6/?report=objectonly" target="object" rid-figpopup="figch2appsfig6" rid-ob="figobch2appsfig6">Figure 126</a> highlights where the inconsistency model better predicted data points, and there were no improvements.</p><p id="ch2.apps.tab7"><a href="/books/NBK557360/table/ch2.apps.tab7/?report=objectonly" target="object" rid-ob="figobch2appstab7" class="figpopup">Table 49. Model fit statistics for ‘Discontinuation for any reason, end point, 12 to 18 year olds with moderate to severe depression</a></p><p id="ch2.apps.fig6"><a href="/books/NBK557360/figure/ch2.apps.fig6/?report=objectonly" target="object" rid-ob="figobch2appsfig6" class="figpopup">Figure 126. Deviance contributions for the fixed effect consistency and inconsistency models</a></p></div></div><div id="ch2.apps.s4"><h4>Conclusions</h4><p>There was evidence of inconsistency in the ‘Depression symptoms, post-treatment, 12–18 year olds, mild’, ‘Depression symptoms, ≤ 6 months, 12 – 18 year olds, mild’, ‘Discontinuation for any reason, endpoint, 12 – 18 year olds, mild’ networks. The data in these networks, particularly for the studies highlighted in Section 3, were scrutinised to ensure there were no errors that could account for these issues, but none were found. The lack of good fit in the ‘Depression symptoms, ≤ 6 months, 12 – 18 year olds, mild’ network was noted, which may be due to inconsistency in the network. Finally, there is large between-study heterogeneity in the ‘Discontinuation for any reason, endpoint, 12 – 18 year olds, mild’ network (posterior median of between study standard deviation: 0.77 (95% CrI: 0.17, 1.78)). These observations were carefully considered when interpreting the evidence.</p><p>Please refer to <a href="#ch2.s1.1.3">methods and processes</a> for details of subsequent analyses and the sensitivity analyses section of the <a href="#ch2.s1.1.11.1.2">quality of the evidence</a> for a discussion of the results of these additional analyses.</p></div><div id="ch2.apps.s5"><h4>Appendix S1. WinBUGS code for inconsistency model used in this report – ‘Depression symptoms post-treatment, 12 – 18 year olds, mild depression’ and ‘Depression symptoms post-treatment, 12 – 18 year olds, moderate to severe depression’</h4><pre>
|
|
# Normal likelihood, identity link: SMD with arm-based means
|
|
# Random effects model
|
|
model{ # *** PROGRAM STARTS
|
|
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
delta[i,1] <- 0 # treatment effect is zero for control arm
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
|
|
for (k in 1:na[i]){
|
|
var[i,k] <- pow(se[i,k],2) # calculate variances
|
|
prec[i,k] <- 1/var[i,k] # set precisions
|
|
y[i,k] ~ dnorm(phi[i,k], prec[i,k]) # normal likelihood
|
|
|
|
phi[i,k]<- theta[i,k] * sdlist[Scale[i]] # theta is SMD
|
|
|
|
theta[i,k] <- mu[i] + delta[i,k] # model for linear predictor
|
|
|
|
#Deviance contribution
|
|
dev[i,k] <- (y[i,k]-phi[i,k])*(y[i,k]-phi[i,k])/var[i,k]
|
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}
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# summed residual deviance contribution for this trial
|
|
resdev[i] <- sum(dev[i,1:na[i]])
|
|
|
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for (k in 2:na[i]){ # LOOP THROUGH ARMS
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# trial-specific RE distributions
|
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delta[i,k] ~ dnorm(md[i,k], tau)
|
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md[i,k] <- d[t[i,1],t[i,k]]
|
|
}
|
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}
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|
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totresdev <- sum(resdev[]) # Total Residual Deviance
|
|
|
|
sd ~ dunif(0,10) # vague prior for for between-trial SD
|
|
tau <- pow(sd,-2) # between-trial precision = (1/between-trial variance)
|
|
|
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# vague priors for treatment effects
|
|
for (c in 1:nt) { d[c,c] <- 0 }
|
|
for (c in 1:(nt-1)) { # priors for all mean treatment effects
|
|
for (k in (c+1):nt) {
|
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d[c,k] ~ dnorm(0,.0001)
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d[k,c] <- -d[c,k]
|
|
}
|
|
}
|
|
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} # *** PROGRAM ENDS
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</pre></div><div id="ch2.apps.s6"><h4>Appendix S2. WinBUGS code for inconsistency model used in this report – ‘Depression symptoms at follow-up up to 6 months, 12 – 18 year olds, mild depression’ and ‘Functional status, >6 to ≤ 18 months, 12 – 18 year olds, mild depression’</h4><pre>
|
|
# Normal likelihood, identity link: SMD with arm-based means
|
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# Fixed effect model
|
|
model{ # *** PROGRAM STARTS
|
|
|
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for(i in 1:ns){ # LOOP THROUGH STUDIES
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mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
|
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for (k in 1:na[i]){
|
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var[i,k] <- pow(se[i,k],2) # calculate variances
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prec[i,k] <- 1/var[i,k] # set precisions
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y[i,k] ~ dnorm(phi[i,k], prec[i,k]) # normal likelihood
|
|
|
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phi[i,k]<- theta[i,k] * sdlist[Scale[i]] # theta is SMD
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|
|
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# model for linear predictor
|
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theta[i,k] <- mu[i] + d[t[i,1],t[i,k]]
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|
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#Deviance contribution
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dev[i,k] <- (y[i,k]-phi[i,k])*(y[i,k]-phi[i,k])/var[i,k]
|
|
}
|
|
|
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# summed residual deviance contribution for this trial
|
|
resdev[i] <- sum(dev[i,1:na[i]])
|
|
|
|
}
|
|
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
|
|
# vague priors for treatment effects
|
|
for (c in 1:nt) { d[c,c] <- 0 }
|
|
for (c in 1:(nt-1)) { # priors for all mean treatment effects
|
|
for (k in (c+1):nt) {
|
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d[c,k] ~ dnorm(0,.0001)
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d[k,c] <- -d[c,k]
|
|
}
|
|
}
|
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} # *** PROGRAM ENDS
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|
</pre></div><div id="ch2.apps.s7"><h4>Appendix S3. WinBUGS code for inconsistency model used in this report – ‘Discontinuation, endpoint, 12 – 18 year olds, mild depression’</h4><pre>
|
|
# Binomial likelihood, logit link
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# Random effects model
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model{ # *** PROGRAM STARTS
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|
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for(i in 1:ns){ # LOOP THROUGH STUDIES
|
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delta[i,1] <- 0 # treatment effect is zero for control arm
|
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mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
|
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for (k in 1:na[i]) { # LOOP THROUGH ARMS
|
|
r[i,k] ~ dbin(p[i,k],n[i,k]) # binomial likelihood
|
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logit(p[i,k]) <- mu[i] + delta[i,k] # model for linear predictor
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|
|
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rhat[i,k] <- p[i,k] * n[i,k] # expected value of the numerators
|
|
|
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#Deviance contribution
|
|
dev[i,k] <- 2 * (r[i,k] * (log(r[i,k])-log(rhat[i,k]))
|
|
+ (n[i,k]-r[i,k]) * (log(n[i,k]-r[i,k]) - log(n[i,k]-rhat[i,k])))
|
|
|
|
}
|
|
|
|
# summed residual deviance contribution for this trial
|
|
resdev[i] <- sum(dev[i,1:na[i]])
|
|
|
|
for (k in 2:na[i]) { # LOOP THROUGH ARMS
|
|
delta[i,k] ~ dnorm(md[i,k],tau) # trial-specific LOR distributions
|
|
md[i,k] <- d[t[i,1],t[i,k]] # mean of LOR distributions
|
|
}
|
|
|
|
}
|
|
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
|
|
|
|
sd ~ dunif(0,5) # vague prior for for between-trial SD
|
|
tau <- pow(sd,-2) # between-trial precision = (1/between-trial variance)
|
|
|
|
|
|
# vague priors for treatment effects
|
|
for (c in 1:nt) { d[c,c] <- 0 }
|
|
for (c in 1:(nt-1)) { # priors for all mean treatment effects
|
|
for (k in (c+1):nt) {
|
|
d[c,k] ~ dnorm(0,.0001)
|
|
d[k,c] <- -d[c,k]
|
|
}
|
|
}
|
|
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.apps.s8"><h4>Appendix S4. WinBUGS code for inconsistency model used in this report – ‘Discontinuation, endpoint, 12 – 18 year olds, moderate to severe depression’</h4><pre>
|
|
# Binomial likelihood, logit link
|
|
# Fixed effect model
|
|
model{ # *** PROGRAM STARTS
|
|
|
|
for(i in 1:ns){ # LOOP THROUGH STUDIES
|
|
mu[i] ~ dnorm(0,.0001) # vague priors for all trial baselines
|
|
|
|
for (k in 1:na[i]) { # LOOP THROUGH ARMS
|
|
r[i,k] ~ dbin(p[i,k],n[i,k]) # binomial likelihood
|
|
|
|
# model for linear predictor
|
|
logit(p[i,k]) <- mu[i] + d[t[i,1],t[i,k]]
|
|
|
|
rhat[i,k] <- p[i,k] * n[i,k] # expected value of the numerators
|
|
|
|
#Deviance contribution
|
|
dev[i,k] <- 2 * (r[i,k] * (log(r[i,k])-log(rhat[i,k]))
|
|
+ (n[i,k]-r[i,k]) * (log(n[i,k]-r[i,k]) - log(n[i,k]-rhat[i,k])))
|
|
|
|
}
|
|
|
|
# summed residual deviance contribution for this trial
|
|
resdev[i] <- sum(dev[i,1:na[i]])
|
|
|
|
}
|
|
|
|
totresdev <- sum(resdev[]) #Total Residual Deviance
|
|
|
|
# vague priors for treatment effects
|
|
for (c in 1:nt) { d[c,c] <- 0 }
|
|
for (c in 1:(nt-1)) { # priors for all mean treatment effects
|
|
for (k in (c+1):nt) {
|
|
d[c,k] ~ dnorm(0,.0001)
|
|
d[k,c] <- -d[c,k]
|
|
}
|
|
}
|
|
|
|
} # *** PROGRAM ENDS
|
|
</pre></div><div id="ch2.apps.rl.r1"><h4>References</h4><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="ch2.apps.ref1">Dias
|
|
S, Welton
|
|
NJ, Sutton
|
|
AJ, Caldwell
|
|
DM, Lu
|
|
G, Ades
|
|
AE. Evidence Synthesis for Decision Making 4: Inconsistency in Networks of Evidence Based on Randomized Controlled Trials. <em>Medical Decision Making</em>. 2013. 33(5):641–656. [<a href="/pmc/articles/PMC3704208/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3704208</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/23804508" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23804508</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="ch2.apps.ref2">Dias
|
|
S, Welton
|
|
NJ, Sutton
|
|
AJ, Caldwell
|
|
DM, Lu
|
|
G, Ades
|
|
AE. NICE DSU Technical Support Document 4: Inconsistency in networks of evidence based on randomised controlled trials. 2011; last updated April 2014. Available from <a href="http://scharr.dept.shef.ac.uk/nicedsu/technical-support-documents/evidence-synthesis-tsd-series/" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">http://scharr<wbr style="display:inline-block"></wbr>​.dept.shef<wbr style="display:inline-block"></wbr>​.ac.uk/nicedsu/technical-support-documents<wbr style="display:inline-block"></wbr>​/evidence-synthesis-tsd-series/</a>. [<a href="https://pubmed.ncbi.nlm.nih.gov/27466656" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27466656</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="ch2.apps.ref3">van Valkenhoef, G, Dias
|
|
S, Ades
|
|
AE, Welton
|
|
NJ. Automated generation of node-splitting models for assessment of inconsistency in network meta-analysis. <em>Research Synthesis Methods</em>. 2016. 7:80–93. [<a href="/pmc/articles/PMC5057346/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5057346</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26461181" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26461181</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="ch2.apps.ref4">Spiegelhalter
|
|
DJ, Best, NG, Carlin
|
|
BP, van der Linde
|
|
A. Bayesian measures of model complexity and fit. <em>Journal of the Royal Statistical Society: Series B</em>. 2002. 64(4):583–616.</div></dd></dl></dl></div></div></div><div><h2 id="NBK557360_footnotes">Footnotes</h2><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.fn1"><p class="no_top_margin">Curtis, L. & Burns, A. (2017) Unit Costs of Health and Social Care 2017, Personal Social Services Research Unit, University of Kent, Canterbury.</p></div></dd></dl></dl></div><div style="display:none"><div style="display:none" id="figch2appgfig1"><img alt="Image ch2appgf66" src-large="/books/NBK557360/bin/ch2appgf66.jpg" /></div><div style="display:none" id="figch2appgfig16"><img alt="Image ch2appgf14" src-large="/books/NBK557360/bin/ch2appgf14.jpg" /></div><div style="display:none" id="figch2appsfig1"><img alt="Image ch2appsf1" src-large="/books/NBK557360/bin/ch2appsf1.jpg" /></div><div style="display:none" id="figch2appsfig2"><img alt="Image ch2appsf2" src-large="/books/NBK557360/bin/ch2appsf2.jpg" /></div><div style="display:none" id="figch2appsfig3"><img alt="Image ch2appsf3" src-large="/books/NBK557360/bin/ch2appsf3.jpg" /></div><div style="display:none" id="figch2appsfig4"><img alt="Image ch2appsf4" src-large="/books/NBK557360/bin/ch2appsf4.jpg" /></div><div style="display:none" id="figch2appsfig5"><img alt="Image ch2appsf5" src-large="/books/NBK557360/bin/ch2appsf5.jpg" /></div><div style="display:none" id="figch2appsfig6"><img alt="Image ch2appsf6" src-large="/books/NBK557360/bin/ch2appsf6.jpg" /></div></div></div><div class="fm-sec"><div><p>Final</p></div><div><p>Evidence review underpinning recommendations 1.5.4 to 1.5.11 (mild depression) and 1.6.1 to 1.6.6 (moderate to severe depression) in the NICE guideline</p><p>These evidence reviews were developed by the NICE Guideline Updates Team</p></div><div><p><b>Disclaimer</b>: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.</p><p>Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.</p><p>NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the <a href="http://wales.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Welsh Government</a>, <a href="http://www.scotland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Scottish Government</a>, and <a href="http://www.northernireland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Northern Ireland Executive</a>. All NICE guidance is subject to regular review and may be updated or withdrawn.</p></div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2019.</div><div class="small"><span class="label">Bookshelf ID: NBK557360</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32479041" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">32479041</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article><article data-type="table-wrap" id="figobch2tab1"><div id="ch2.tab1" class="table"><h3><span class="label">Table 1</span><span class="title">PICO table for psychological interventions review</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab1_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><td headers="hd_b_ch2.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Children and young people aged 5 to 18 years with recognised symptoms of depressive disorder</td></tr><tr><th id="hd_b_ch2.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interventions</th><td headers="hd_b_ch2.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l1"><li id="ch2.lt1" class="half_rhythm"><div>Individual cognitive behavioural therapy (CBT)</div></li><li id="ch2.lt2" class="half_rhythm"><div>Group CBT</div></li><li id="ch2.lt3" class="half_rhythm"><div>Individual computer-based CBT</div></li><li id="ch2.lt4" class="half_rhythm"><div>CBT with separate parent sessions</div></li><li id="ch2.lt5" class="half_rhythm"><div>Dialectical behavioural therapy (DBT)</div></li><li id="ch2.lt6" class="half_rhythm"><div>Interpersonal psychotherapy (also known as interpersonal therapy, IPT, and IPT-A [IPT for adolescents])</div></li><li id="ch2.lt7" class="half_rhythm"><div>Group IPT</div></li><li id="ch2.lt8" class="half_rhythm"><div>Psychodynamic child psychotherapy (psychoanalytic child psychotherapy is included as a specific type of subtype of psychodynamic psychotherapy)</div></li><li id="ch2.lt9" class="half_rhythm"><div>Self-modelling</div></li><li id="ch2.lt10" class="half_rhythm"><div>Relaxation</div></li><li id="ch2.lt11" class="half_rhythm"><div>Social skills training</div></li><li id="ch2.lt12" class="half_rhythm"><div>Systemic therapy</div></li><li id="ch2.lt13" class="half_rhythm"><div>Family therapy (excluding CBT with parental involvement)</div></li><li id="ch2.lt14" class="half_rhythm"><div>Control enhancement training</div></li><li id="ch2.lt15" class="half_rhythm"><div>Individual non-directive supportive therapy (NDST)</div></li><li id="ch2.lt16" class="half_rhythm"><div>Group NDST</div></li><li id="ch2.lt17" class="half_rhythm"><div>Guided self-help including:
|
|
<ul id="ch2.l2" class="circle"><li id="ch2.lt18" class="half_rhythm"><div>Bibliotherapy</div></li><li id="ch2.lt19" class="half_rhythm"><div>Apps targeting depression (that are separate from computer-based CBT)</div></li></ul></div></li><li id="ch2.lt20" class="half_rhythm"><div>Mindfulness-based cognitive therapy</div></li><li id="ch2.lt21" class="half_rhythm"><div>Mindfulness (other than mindfulness-based cognitive therapy)</div></li><li id="ch2.lt22" class="half_rhythm"><div>Psychosocial interventions</div></li><li id="ch2.lt23" class="half_rhythm"><div>Psychoeducation</div></li><li id="ch2.lt24" class="half_rhythm"><div>Behavioural activation</div></li><li id="ch2.lt25" class="half_rhythm"><div>Eye movement desensitisation and reprocessing</div></li><li id="ch2.lt26" class="half_rhythm"><div>Counselling</div></li><li id="ch2.lt27" class="half_rhythm"><div>Arts/creative psychotherapies
|
|
<ul id="ch2.l3" class="circle"><li id="ch2.lt28" class="half_rhythm"><div>Art therapy</div></li><li id="ch2.lt29" class="half_rhythm"><div>Psychodrama</div></li><li id="ch2.lt30" class="half_rhythm"><div>Music therapy</div></li><li id="ch2.lt31" class="half_rhythm"><div>Dance therapy</div></li></ul></div></li><li id="ch2.lt32" class="half_rhythm"><div>Play therapy</div></li></ul></td></tr><tr><th id="hd_b_ch2.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparator</th><td headers="hd_b_ch2.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l4"><li id="ch2.lt33" class="half_rhythm"><div>Any of the interventions listed above</div></li><li id="ch2.lt34" class="half_rhythm"><div>Waiting list</div></li><li id="ch2.lt35" class="half_rhythm"><div>No intervention</div></li><li id="ch2.lt36" class="half_rhythm"><div>Attention control</div></li><li id="ch2.lt37" class="half_rhythm"><div>Usual care</div></li></ul></td></tr><tr><th id="hd_b_ch2.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes</th><td headers="hd_b_ch2.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Primary outcomes:</b>
|
|
<ul id="ch2.l5"><li id="ch2.lt38" class="half_rhythm"><div>Level of function (functional status)</div></li><li id="ch2.lt39" class="half_rhythm"><div>Depression symptoms following treatment</div></li><li id="ch2.lt40" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt41" class="half_rhythm"><div>Quality of life</div></li></ul>
|
|
<b>Secondary outcomes</b>:
|
|
<ul id="ch2.l6"><li id="ch2.lt42" class="half_rhythm"><div>Suicide-related adverse events during or following treatment (including numbers of suicides if reported)</div></li><li id="ch2.lt43" class="half_rhythm"><div>Suicidal ideation</div></li><li id="ch2.lt44" class="half_rhythm"><div>Self-harm (self-injury or self-poisoning regardless of intent)</div></li><li id="ch2.lt45" class="half_rhythm"><div>Discontinuation from treatment (due to adverse events or for any reason)</div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2tab2"><div id="ch2.tab2" class="table"><h3><span class="label">Table 2</span><span class="title">Number of included studies for each comparison for all age and depression severity groups. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></th><th id="hd_h_ch2.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Waiting list/no treatment</th><th id="hd_h_ch2.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Attention control</th><th id="hd_h_ch2.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Monitoring</th><th id="hd_h_ch2.tab2_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Pill placebo</th><th id="hd_h_ch2.tab2_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Individual CBT</th><th id="hd_h_ch2.tab2_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Computer CBT</th><th id="hd_h_ch2.tab2_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Group CBT</th><th id="hd_h_ch2.tab2_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Guided self-help</th><th id="hd_h_ch2.tab2_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Family therapy</th><th id="hd_h_ch2.tab2_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Family based IPT</th><th id="hd_h_ch2.tab2_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IPT-A</th><th id="hd_h_ch2.tab2_1_1_1_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NDST</th><th id="hd_h_ch2.tab2_1_1_1_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.tab2_1_1_1_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relaxation</th><th id="hd_h_ch2.tab2_1_1_1_17" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Group IPT</th></tr></thead><tbody><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Individual CBT</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8</td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT plus parent sessions</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guided self help</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Online guided self-help</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family psychoeducation with CBT</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NDST</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_11_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relaxation</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_12_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-modelling</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A with additional parent sessions</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dance therapy</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BA</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group IPT</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT plus group CBT</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group mindfulness</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab2_1_1_1_1" id="hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Creative play therapy</th><td headers="hd_h_ch2.tab2_1_1_1_2 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab2_1_1_1_3 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_4 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_5 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_6 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_7 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_8 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_9 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_10 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_11 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_12 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_13 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_14 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_15 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_16 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab2_1_1_1_17 hd_b_ch2.tab2_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">BA: behavioural activation; CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; IPT-A: IPT for adolescents; NDST: non-directive supportive therapy</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab3"><div id="ch2.tab3" class="table"><h3><span class="label">Table 3</span><span class="title">Number of included studies for each comparison for mild depression, age 5–11 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></th><th id="hd_h_ch2.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Waiting list/no treatment</th><th id="hd_h_ch2.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Attention control</th><th id="hd_h_ch2.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Monitoring</th><th id="hd_h_ch2.tab3_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Pill placebo</th><th id="hd_h_ch2.tab3_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Ind CBT</th><th id="hd_h_ch2.tab3_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Computer CBT</th><th id="hd_h_ch2.tab3_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Group CBT</th><th id="hd_h_ch2.tab3_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Guided self-help</th><th id="hd_h_ch2.tab3_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Family therapy</th><th id="hd_h_ch2.tab3_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IPT-A</th><th id="hd_h_ch2.tab3_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NDST</th><th id="hd_h_ch2.tab3_1_1_1_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.tab3_1_1_1_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relaxation</th></tr></thead><tbody><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Individual CBT</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT plus parent sessions</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guided self help</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NDST</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relaxation</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-modelling</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A plus parent sessions</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dance therapy</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychoeducation</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BA</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group IPT</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT plus group CBT</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab3_1_1_1_1" id="hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group mindfulness</th><td headers="hd_h_ch2.tab3_1_1_1_2 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_3 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_4 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_5 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_6 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_7 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_8 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_9 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_10 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_11 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_12 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_13 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_14 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab3_1_1_1_15 hd_b_ch2.tab3_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">BA: behavioural activation; CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; IPT-A: IPT for adolescents; NDST: non-directive supportive therapy</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab4"><div id="ch2.tab4" class="table"><h3><span class="label">Table 4</span><span class="title">Number of included studies for each comparison for mild depression, age 12–18 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab4_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></th><th id="hd_h_ch2.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Waiting list/no treatment</th><th id="hd_h_ch2.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Attention control</th><th id="hd_h_ch2.tab4_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Monitoring</th><th id="hd_h_ch2.tab4_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Pill placebo</th><th id="hd_h_ch2.tab4_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Ind CBT</th><th id="hd_h_ch2.tab4_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Computer CBT</th><th id="hd_h_ch2.tab4_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Group CBT</th><th id="hd_h_ch2.tab4_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Guided self-help</th><th id="hd_h_ch2.tab4_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Family therapy</th><th id="hd_h_ch2.tab4_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IPT-A</th><th id="hd_h_ch2.tab4_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NDST</th><th id="hd_h_ch2.tab4_1_1_1_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.tab4_1_1_1_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relaxation</th><th id="hd_h_ch2.tab4_1_1_1_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Group IPT</th></tr></thead><tbody><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Individual CBT</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT plus parent sessions</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guided self help</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NDST</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relaxation</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-modelling</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group NDST</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A plus parent sessions</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dance therapy</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychoeducation</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BA</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group IPT</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT plus group CBT</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group mindfulness</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_20_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab4_1_1_1_1" id="hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Creative play therapy</th><td headers="hd_h_ch2.tab4_1_1_1_2 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab4_1_1_1_3 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_4 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_5 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_6 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_7 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_8 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_9 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_10 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_11 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_12 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_13 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_14 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_15 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab4_1_1_1_16 hd_b_ch2.tab4_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2tab5"><div id="ch2.tab5" class="table"><h3><span class="label">Table 5</span><span class="title">Number of included studies for each comparison for moderate to severe depression, age 5–11 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab5_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></th><th id="hd_h_ch2.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Waiting list/no treatment</th><th id="hd_h_ch2.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Attention control</th><th id="hd_h_ch2.tab5_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Monitoring</th><th id="hd_h_ch2.tab5_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Pill placebo</th><th id="hd_h_ch2.tab5_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Ind CBT</th><th id="hd_h_ch2.tab5_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Computer CBT</th><th id="hd_h_ch2.tab5_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Group CBT</th><th id="hd_h_ch2.tab5_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Guided self-help</th><th id="hd_h_ch2.tab5_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Family therapy</th><th id="hd_h_ch2.tab5_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Family based IPT</th><th id="hd_h_ch2.tab5_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IPT-A</th><th id="hd_h_ch2.tab5_1_1_1_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NDST</th><th id="hd_h_ch2.tab5_1_1_1_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.tab5_1_1_1_16" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relaxation</th></tr></thead><tbody><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Individual CBT</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT plus parent sessions</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guided self help</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family psychoeducation with CBT</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NDST</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relaxation</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-modelling</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A plus parent sessions</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dance therapy</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BA</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group IPT</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT plus group CBT</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab5_1_1_1_1" id="hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group mindfulness</th><td headers="hd_h_ch2.tab5_1_1_1_2 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_3 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_4 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_5 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_6 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_7 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_8 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_9 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_10 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_11 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_12 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_13 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_14 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_15 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab5_1_1_1_16 hd_b_ch2.tab5_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">BA: behavioural activation; CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; IPT-A: IPT for adolescents; NDST: non-directive supportive therapy</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab6"><div id="ch2.tab6" class="table"><h3><span class="label">Table 6</span><span class="title">Number of included studies for each comparison for moderate to severe depression, age 12–18 years. Blank cells indicate comparisons for which no studies were included; some interventions were not added in columns because there were no RCTs reporting on all comparisons</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab6_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;"></th><th id="hd_h_ch2.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Waiting list/no treatment</th><th id="hd_h_ch2.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Attention control</th><th id="hd_h_ch2.tab6_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Monitoring</th><th id="hd_h_ch2.tab6_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Pill placebo</th><th id="hd_h_ch2.tab6_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Ind CBT</th><th id="hd_h_ch2.tab6_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Computer CBT</th><th id="hd_h_ch2.tab6_1_1_1_9" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Group CBT</th><th id="hd_h_ch2.tab6_1_1_1_10" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Online guided self-help</th><th id="hd_h_ch2.tab6_1_1_1_11" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Family therapy</th><th id="hd_h_ch2.tab6_1_1_1_12" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">IPT-A</th><th id="hd_h_ch2.tab6_1_1_1_13" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">NDST</th><th id="hd_h_ch2.tab6_1_1_1_14" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.tab6_1_1_1_15" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Relaxation</th></tr></thead><tbody><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Individual CBT</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_3_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT plus parent sessions</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_4_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Online guided self help</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_5_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_6_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NDST</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relaxation</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d0d0d0;text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-modelling</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A with additional parent sessions</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dance therapy</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychoeducation</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BA</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group IPT</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT plus group CBT</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><th headers="hd_h_ch2.tab6_1_1_1_1" id="hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group mindfulness</th><td headers="hd_h_ch2.tab6_1_1_1_2 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_3 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_4 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_5 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_6 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_7 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_8 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_9 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_10 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_11 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_12 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_13 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_14 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.tab6_1_1_1_15 hd_b_ch2.tab6_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">BA: behavioural activation; CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; IPT-A: IPT for adolescents; NDST: non-directive supportive therapy</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2tab7"><div id="ch2.tab7" class="table"><h3><span class="label">Table 7</span><span class="title">Summary of the characteristics of the included studies</span></h3><div class="caption"><p>Studies were classified into 2 age groups: 5 to 11 years and 12 to 18 years. This classification was based on age range or mean age reported by the studies. Classifications used in the 2015 update of this review were retained here. However, some studies may have recruited across the age boundary and were assigned to the younger or the older group based on their mean age. The table below summarises the classification for each study by age group and level of severity, with the presence of depression symptoms being used to indicate mild depression and a diagnosis of a depressive disorder indicating moderate to severe depression.</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab7_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study reference</th><th id="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study Design</th><th id="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study population</th><th id="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention & comparator</th><th id="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relevant outcomes</th></tr></thead><tbody><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref2" rid="ch2.appo.ref2">Ackerson 1998</a>
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</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Young people with depression symptoms</p>
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<p>Age: 12 to 18</p>
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<p>Location : US</p>
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<p>Setting: Community</p>
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</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guided self-help vs attention control</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l17"><li id="ch2.lt90" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref3" rid="ch2.appo.ref3">Alavi 2013</a>
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</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Young people with diagnosed depressive disorder</p>
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<p>Age: 12 to 18</p>
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<p>Location: Iran</p>
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<p>Setting: Hospital</p>
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</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l18"><li id="ch2.lt91" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt92" class="half_rhythm"><div>Suicidal ideation</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref4" rid="ch2.appo.ref4">Asarnow 2002</a>
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</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Young people with depression symptoms</p>
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<p>Age: 12 to 18</p>
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<p>Location: US</p>
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<p>Setting: School</p>
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</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l19"><li id="ch2.lt93" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref5" rid="ch2.appo.ref5">Bella-Awusah 2015</a>
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</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Young people with depression symptoms</p>
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<p>Age: 12 to 18</p>
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<p>Location: Nigeria</p>
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<p>Setting: Public schools</p>
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</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l20"><li id="ch2.lt94" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt95" class="half_rhythm"><div>Functional status</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref6" rid="ch2.appo.ref6">Bolton 2007</a>
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</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Uganda</p>
|
|
<p>Setting: Camps for internally displaced persons in northern Uganda</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group interpersonal therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l21"><li id="ch2.lt96" class="half_rhythm"><div>Discontinuation</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: secondary care</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs family therapy vs non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l22"><li id="ch2.lt97" class="half_rhythm"><div>Function status</div></li><li id="ch2.lt98" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt99" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt100" class="half_rhythm"><div>Suicidal ideation</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref8" rid="ch2.appo.ref8">Brent 2015</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Hospital and university sites</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l23"><li id="ch2.lt101" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref9" rid="ch2.appo.ref9">Charkhande 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Iran</p>
|
|
<p>Setting: Psychotherapy clinics</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l24"><li id="ch2.lt102" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref10" rid="ch2.appo.ref10">Clarke 1995</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l25"><li id="ch2.lt103" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt104" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt105" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Research</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs group cognitive behavioural therapy + parent sessions vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l26"><li id="ch2.lt106" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt107" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref12" rid="ch2.appo.ref12">Clarke 2001</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Research</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l27"><li id="ch2.lt108" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt109" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt110" class="half_rhythm"><div>Suicidal ideation</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref13" rid="ch2.appo.ref13">Clarke 2002</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Research</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l28"><li id="ch2.lt111" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt112" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt113" class="half_rhythm"><div>Suicidal ideation</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l29"><li id="ch2.lt114" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt115" class="half_rhythm"><div>Suicidal ideation</div></li><li id="ch2.lt116" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt117" class="half_rhythm"><div>Quality of life</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref15" rid="ch2.appo.ref15">De Cuyper 2004</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Children with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Belgium</p>
|
|
<p>Setting: Research</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l30"><li id="ch2.lt118" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref16" rid="ch2.appo.ref16">Diamond 2002</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy vs attention control</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l31"><li id="ch2.lt119" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt120" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref17" rid="ch2.appo.ref17">Diamond 2010</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Hospital</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l32"><li id="ch2.lt121" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt122" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref18" rid="ch2.appo.ref18">Dietz 2015</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 5 to 11</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Outpatient psychotherapy</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family based IPT vs non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l33"><li id="ch2.lt123" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt124" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref19" rid="ch2.appo.ref19">Dobson 2010</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Iran</p>
|
|
<p>Setting; Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs attention control</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l34"><li id="ch2.lt125" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt126" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref20" rid="ch2.appo.ref20">Duong 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Public schools</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l35"><li id="ch2.lt127" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref22" rid="ch2.appo.ref22">Feehan 1996</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: UK</p>
|
|
<p>Setting: Secondary care</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l36"><li id="ch2.lt128" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref23" rid="ch2.appo.ref23">Fleming 2012</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: New Zealand</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer-based cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l37"><li id="ch2.lt129" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt130" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref24" rid="ch2.appo.ref24">Fristad 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 5 to 11</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family psychoeducation with CBT vs pill placebo</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l38"><li id="ch2.lt131" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt132" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref25" rid="ch2.appo.ref25">Gaete 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Chile</p>
|
|
<p>Setting: Secondary schools</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs no treatment</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l39"><li id="ch2.lt133" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt134" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Goodyer 2017a</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: UK</p>
|
|
<p>Setting: CAMHS clinics</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CBT vs psychodynamic psychotherapy vs psychosocial intervention</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l40"><li id="ch2.lt135" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt136" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt137" class="half_rhythm"><div>Quality of life</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interpersonal psychotherapy for adolescents vs interpersonal psychotherapy for adolescents plus additional parent sessions</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l41"><li id="ch2.lt138" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt139" class="half_rhythm"><div>Functional status</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref30" rid="ch2.appo.ref30">Hayes 2011</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Australia</p>
|
|
<p>Setting: Secondary care</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l42"><li id="ch2.lt140" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref31" rid="ch2.appo.ref31">Hogberg 2018</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Stockholm</p>
|
|
<p>Setting: Outpatients units</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l43"><li id="ch2.lt141" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt142" class="half_rhythm"><div>Suicidal ideation</div></li><li id="ch2.lt143" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref32" rid="ch2.appo.ref32">Ip 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: China</p>
|
|
<p>Setting: Secondary schools</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer-based cognitive behavioural therapy vs attention control</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l44"><li id="ch2.lt144" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref33" rid="ch2.appo.ref33">Israel 2013</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Norway</p>
|
|
<p>Setting: Outpatient clinics</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l45"><li id="ch2.lt145" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt146" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref34" rid="ch2.appo.ref34">Jacob 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Philippines</p>
|
|
<p>Setting: High schools</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guided self-help vs no treatment</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l46"><li id="ch2.lt147" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref35" rid="ch2.appo.ref35">Jeong 2005</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Korea</p>
|
|
<p>Setting Middle school</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dance therapy vs no treatment</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l47"><li id="ch2.lt148" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs relaxation vs self-modelling vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l48"><li id="ch2.lt149" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref39" rid="ch2.appo.ref39">Kobak 2015</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CBT vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l49"><li id="ch2.lt150" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewinsohn 1990</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs group cognitive behavioural therapy plus parent sessions vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l50"><li id="ch2.lt151" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt152" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref42" rid="ch2.appo.ref42">Liddle 1990</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Children with diagnosed depressive disorder</p>
|
|
<p>Age: 5 to 11</p>
|
|
<p>Location: Australia</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l51"><li id="ch2.lt153" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref43" rid="ch2.appo.ref43">Listug-Lunde 2013</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Middle school</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l52"><li id="ch2.lt154" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March/TADS 2004</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Academic and community clinics</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs pill placebo</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l53"><li id="ch2.lt155" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt156" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt157" class="half_rhythm"><div>Suicidal ideation</div></li><li id="ch2.lt158" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref46" rid="ch2.appo.ref46">McCauley 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Behavioural activation vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l54"><li id="ch2.lt159" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt160" class="half_rhythm"><div>Functional status</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref47" rid="ch2.appo.ref47">Merry 2012</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: New Zealand</p>
|
|
<p>Setting: Primary care</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer-based cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l55"><li id="ch2.lt161" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt162" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref48" rid="ch2.appo.ref48">Mufson 1999</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Secondary care</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interpersonal psychotherapy for adolescents vs monitoring</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l56"><li id="ch2.lt163" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt164" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interpersonal psychotherapy for adolescents vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l57"><li id="ch2.lt165" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt166" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt167" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref50" rid="ch2.appo.ref50">Noel 2013</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l58"><li id="ch2.lt168" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Australia</p>
|
|
<p>Setting: School of Psychology Clinic and State High School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interpersonal psychotherapy for adolescents vs group interpersonal psychotherapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l59"><li id="ch2.lt169" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt170" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt171" class="half_rhythm"><div>Functional status</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref52" rid="ch2.appo.ref52">Poole 2018</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Australia</p>
|
|
<p>Setting: Community</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l60"><li id="ch2.lt172" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt173" class="half_rhythm"><div>Functional status</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Netherlands</p>
|
|
<p>Setting: Secondary education</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs computer-based cognitive behavioural therapy vs combined interventions vs attention control</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l61"><li id="ch2.lt174" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt175" class="half_rhythm"><div>Suicidal ideation</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref54" rid="ch2.appo.ref54">Puskar 2003</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs no treatment</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l62"><li id="ch2.lt176" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs relaxation vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l63"><li id="ch2.lt177" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref56" rid="ch2.appo.ref56">Rickhi 2015</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Canada</p>
|
|
<p>Setting: Canadian Institute of Natural and Integrative Medicine</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Online guided self-help vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l64"><li id="ch2.lt178" class="half_rhythm"><div>Depressive symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rosello 1999</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Puerto Rico</p>
|
|
<p>Setting: Research</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interpersonal psychotherapy for adolescents vs cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l65"><li id="ch2.lt179" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt180" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref58" rid="ch2.appo.ref58">Shirk 2014</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Community clinics</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l66"><li id="ch2.lt181" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Centre for family and couple therapy</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs group mindfulness</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l67"><li id="ch2.lt182" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt183" class="half_rhythm"><div>Discontinuation</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref60" rid="ch2.appo.ref60">Smith 2015</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: UK</p>
|
|
<p>Setting: Secondary schools</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer-based cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l68"><li id="ch2.lt184" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt185" class="half_rhythm"><div>Functional status</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: UK</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs attention control vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l69"><li id="ch2.lt186" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref63" rid="ch2.appo.ref63">Stark 1987</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Children with depression symptoms</p>
|
|
<p>Age: 5 to 11</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs waiting list</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l70"><li id="ch2.lt187" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms.</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: New Zealand</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer-based cognitive behavioural therapy vs attention control</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l71"><li id="ch2.lt188" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt189" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt190" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting : School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs non-directive supportive therapy vs guided self-help vs monitoring</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l72"><li id="ch2.lt191" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy 2007</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms Comorbidity: irritable bowel syndrome</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Hospital</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l73"><li id="ch2.lt192" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt193" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy 2014</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder Comorbidity: irritable bowel syndrome</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Hospital</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l74"><li id="ch2.lt194" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref70" rid="ch2.appo.ref70">Tompson 2017</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 5 to 11</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Not reported</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy vs non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l75"><li id="ch2.lt195" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt196" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt197" class="half_rhythm"><div>Functional status</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref71" rid="ch2.appo.ref71">Topooco 2018</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Sweden</p>
|
|
<p>Setting: Online</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer-based cognitive behavioural therapy vs attention control</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l76"><li id="ch2.lt198" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt199" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Children with diagnosed depressive disorder</p>
|
|
<p>Age: 5 to 11</p>
|
|
<p>Location: Greece, Finland, UK</p>
|
|
<p>Setting: Secondary care</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy vs family therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l77"><li id="ch2.lt200" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt201" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt202" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt203" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Vostanis 1996a</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: UK</p>
|
|
<p>Setting: Secondary care</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l78"><li id="ch2.lt204" class="half_rhythm"><div>Remission</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref77" rid="ch2.appo.ref77">Weisz 1997</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Children with depression symptoms</p>
|
|
<p>Age: 5 to 11</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs no treatment</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l79"><li id="ch2.lt205" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref78" rid="ch2.appo.ref78">Weisz 2009</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Children with diagnosed depressive disorder</p>
|
|
<p>Age: 5 to 11</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Community clinic</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs usual care</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l80"><li id="ch2.lt206" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref79" rid="ch2.appo.ref79">Wijnhoven 2014</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: Netherlands</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group cognitive behavioural therapy vs no treatment</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l81"><li id="ch2.lt207" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref80" rid="ch2.appo.ref80">Wood 1996</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with diagnosed depressive disorder</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: UK</p>
|
|
<p>Setting: Secondary care</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive behavioural therapy vs relaxation</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l82"><li id="ch2.lt208" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt209" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt210" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt211" class="half_rhythm"><div>Discontinuation for any reason</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref81" rid="ch2.appo.ref81">Wright 2017</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: UK</p>
|
|
<p>Setting: CAMHS, GP or community centre</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer-based cognitive behavioural therapy vs attention control</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l83"><li id="ch2.lt212" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt213" class="half_rhythm"><div>Quality of life</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref82" rid="ch2.appo.ref82">Young 2006</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group interpersonal psychotherapy vs group non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l84"><li id="ch2.lt214" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt215" class="half_rhythm"><div>Functional status</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: School</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group interpersonal psychotherapy vs group non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l85"><li id="ch2.lt216" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt217" class="half_rhythm"><div>Depression symptoms</div></li></ul></td></tr><tr><td headers="hd_h_ch2.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Young people with depression symptoms</p>
|
|
<p>Age: 12 to 18</p>
|
|
<p>Location: US</p>
|
|
<p>Setting: Middle and high schools</p>
|
|
</td><td headers="hd_h_ch2.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group interpersonal psychotherapy vs group non-directive supportive therapy</td><td headers="hd_h_ch2.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l86"><li id="ch2.lt218" class="half_rhythm"><div>Depressive symptoms</div></li><li id="ch2.lt219" class="half_rhythm"><div>Functional status</div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2tab8"><div id="ch2.tab8" class="table"><h3><span class="label">Table 8</span><span class="title">Summary of economic evaluations included in the review</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.tab8_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study</th><th id="hd_h_ch2.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Comparators</th><th id="hd_h_ch2.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Costs</th><th id="hd_h_ch2.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effects</th><th id="hd_h_ch2.tab8_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Cost-effectiveness</th><th id="hd_h_ch2.tab8_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Uncertainty</th><th id="hd_h_ch2.tab8_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Applicability</th><th id="hd_h_ch2.tab8_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Limitations</th></tr></thead><tbody><tr><td headers="hd_h_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a> (IMPACT HTA) – Trial based economic evaluation</td><td headers="hd_h_ch2.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1: BPI</p>
|
|
<p>INT2: CBT</p>
|
|
<p>INT3: STPP</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>BPI: £2678</p>
|
|
<p>CBT: £2379</p>
|
|
<p>STPP: £3082</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>QALYs:</p>
|
|
<p>CBT: 1.228</p>
|
|
<p>BPI: 1.241</p>
|
|
<p>STPP: 1.246</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><b>ICER BPI vs CBT:</b> £23,000/QALY</p>
|
|
<p><b>ICER STPP vs CBT:</b> £80,800/QALY</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>CBT was the strategy with highest probability of being cost-effective.</p>
|
|
<p>When the cost of sessions not attended was included BPI became the most cost-effective intervention.</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Directly applicable</td><td headers="hd_h_ch2.tab8_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Potentially serious limitations</td></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a class="bibr" href="#ch2.appo.ref251" rid="ch2.appo.ref251">Byford 2007</a> – Trial based economic evaluation</td><td headers="hd_h_ch2.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1: CBT + SSRIs</p>
|
|
<p>INT2: SSRIs + clinical care</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1: £1,272</p>
|
|
<p>INT2: £36</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1: 0.36</p>
|
|
<p>INT2: 0.38</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INT1 was dominated<sup>(a)</sup> by INT2.</td><td headers="hd_h_ch2.tab8_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The probability of INT1 being more cost-effective than IN2 was 25% at a willingness to pay of £50,000. At a willingness to pay of £100,000 this probability did not rise above 26%.</td><td headers="hd_h_ch2.tab8_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Partially applicable</td><td headers="hd_h_ch2.tab8_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Potentially serious limitations</td></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a class="bibr" href="#ch2.appo.ref173" rid="ch2.appo.ref173">Dickerson et al 2018</a> – Trial based economic evaluation</td><td headers="hd_h_ch2.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1: TAU</p>
|
|
<p>INT2: TAU + CBT</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1: $8,631</p>
|
|
<p>INT2: $3,655</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT2 vs INT1</p>
|
|
<p>Depression free days: 43.3</p>
|
|
<p>QALYs: 0.109</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INT2 dominates</td><td headers="hd_h_ch2.tab8_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Probabilistic sensitivity analysis suggests INT2 has a 97% probability of dominating INT1.</p>
|
|
<p>Other sensitivity analysis did not change the direction of the conclusions.</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Partially applicable</td><td headers="hd_h_ch2.tab8_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Potentially serious limitations</td></tr><tr><td headers="hd_h_ch2.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a class="bibr" href="#ch2.appo.ref253" rid="ch2.appo.ref253">Domino 2009</a> – Trial based economic evaluation</td><td headers="hd_h_ch2.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1: fluoxetine</p>
|
|
<p>INT2: CBT</p>
|
|
<p>INT3: fluoxetine + CBT</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1: £5,924</p>
|
|
<p>INT2: £4,999</p>
|
|
<p>INT3: £5,618</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>QALY:</p>
|
|
<p>INT1 vs INT2: −0.0067</p>
|
|
<p>INT1 vs INT3: 0.0012</p>
|
|
</td><td headers="hd_h_ch2.tab8_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>INT1 vs INT2</p>
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<p>ICER: $52,200 (£46,266)</p>
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<p>INT1 vs INT3</p>
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<p>ICER: $−23,067 (-£20,444)</p>
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<p>INT3 dominates</p>
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</td><td headers="hd_h_ch2.tab8_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Probabilistic sensitivity analysis has shown that INT3 has a greater than 90% probability of being the most cost-effective strategy.</p>
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<p>The results of the analysis were sensible to the measure of effect used in the analysis.</p>
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</td><td headers="hd_h_ch2.tab8_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Partially applicable</td><td headers="hd_h_ch2.tab8_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Potentially serious limitations</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">BPI, brief psychological intervention; CBT, cognitive behavioural therapy; HTA, health technology assessment; ICER, incremental cost-effectiveness analysis; QALY, quality-adjusted life year; SSRIs, selective serotonin reuptake inhibitors; STPP, short-term psychoanalytic psychotherapy; TAU, treatment as usual.</p></div></dd></dl><dl class="bkr_refwrap"><dt>(a)</dt><dd><div id="ch2.tab8_1"><p class="no_margin">Intervention 1 was dominated because it was more expensive and less effective than intervention 2.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2appbtab1"><div id="ch2.appb.tab1" class="table"><h3><span class="label">Table 9</span><span class="title">Identified MIDs</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appb.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Outcome</th><th id="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">MID</th><th id="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Source</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Children’s global assessment scale</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>10 points</p>
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<p>(−10,+10)</p>
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</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Bird HR, Canino G, Rubio-Stipec M et al. Further Measures of the Psychometric Properties of the Children’s Global Assessment Scale. Archives of General Psychiatry 1987, 44(9):821–824.</p>
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<p>Green B, Shirk S, Hanze D et al. The Children’s Global Assessment Scale in clinical practice: an empirical evaluation. Journal of the American Academy of Child Adolescent Psychiatry 1994, 33(8):1158–1164.</p>
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</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Child depression inventory</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>8 points</p>
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<p>(−8, +8)</p>
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</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Lobovits DA, and Handal PJ. Childhood depression: Prevalence using DSM-III criteria and validity of parent and child depression scales. Journal of Pediatric Psychology 1985, 10(1):45–54.</p>
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<p>Finch Jr AJ, Saylor CF, Edwards GL, et al. Children’s Depression Inventory: Reliability over repeated administrations. Journal of Clinical Child Psychology 1987, 16(4):339–341.</p>
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</td></tr><tr><td headers="hd_h_ch2.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Health of the Nation Outcome Scales for Children and Adolescents</td><td headers="hd_h_ch2.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>10 points</p>
|
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<p>(−10,+10)</p>
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</td><td headers="hd_h_ch2.appb.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Hanssen-Bauer K, Heyerdahl S, Hatling T, et al. Admissions to acute adolescent psychiatric units: a prospective study of clinical severity and outcome. International Journal of Mental Health Systems 2011, 5(1):1–11.</p>
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<p>Garralda ME, Yates P, and Higginson I. Child and adolescent mental health use: HoNOSCA as an outcome measure. The British Journal of Psychiatry 2000, 177:52–58.</p>
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</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab2"><div id="ch2.appb.tab2" class="table"><h3><span class="label">Table 10</span><span class="title">Rationale for downgrading quality of evidence for intervention studies</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appb.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">GRADE criteria</th><th id="hd_h_ch2.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reasons for downgrading quality</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk of bias</td><td headers="hd_h_ch2.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Not serious: If less than 33.3% of the weight in a meta-analysis came from studies at moderate or high risk of bias, the overall outcome was not downgraded.</p>
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<p>Serious: If greater than 33.3% of the weight in a meta-analysis came from studies at moderate or high risk of bias, the outcome was downgraded one level.</p>
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<p>Very serious: If greater than 33.3% of the weight in a meta-analysis came from studies at high risk of bias, the outcome was downgraded two levels.</p>
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<p>Outcomes meeting the criteria for downgrading above were not downgraded if there was evidence the effect size was not meaningfully different between studies at high and low risk of bias.</p>
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</td></tr><tr><td headers="hd_h_ch2.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Indirectness</td><td headers="hd_h_ch2.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Not serious: If less than 33.3% of the weight in a meta-analysis came from partially indirect or indirect studies, the overall outcome was not downgraded.</p>
|
|
<p>Serious: If greater than 33.3% of the weight in a meta-analysis came from partially indirect or indirect studies, the outcome was downgraded one level.</p>
|
|
<p>Very serious: If greater than 33.3% of the weight in a meta-analysis came from indirect studies, the outcome was downgraded two levels.</p>
|
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<p>Outcomes meeting the criteria for downgrading above were not downgraded if there was evidence the effect size was not meaningfully different between direct and indirect studies.</p>
|
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</td></tr><tr><td headers="hd_h_ch2.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency</td><td headers="hd_h_ch2.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Concerns about inconsistency of effects across studies, occurring when there is unexplained variability in the treatment effect demonstrated across studies (heterogeneity), after appropriate pre-specified subgroup analyses have been conducted. This was assessed using the I<sup>2</sup> statistic.</p>
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<p>N/A: Inconsistency was marked as not applicable if data on the outcome was only available from one study.</p>
|
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<p>Not serious: If the I<sup>2</sup> was less than 33.3%, the outcome was not downgraded.</p>
|
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<p>Serious: If the I<sup>2</sup> was between 33.3% and 66.7%, the outcome was downgraded one level.</p>
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<p>Very serious: If the I<sup>2</sup> was greater than 66.7%, the outcome was downgraded two levels.</p>
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<p>Outcomes meeting the criteria for downgrading above were not downgraded if there was evidence the effect size was not meaningfully different between studies with the smallest and largest effect sizes.</p>
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</td></tr><tr><td headers="hd_h_ch2.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Imprecision</td><td headers="hd_h_ch2.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This was not included in the GRADE table, but was considered during committee discussions of the evidence, taking into account 95% confidence intervals around the point estimate of the effect, any relevant MIDs, committee expertise and the effect of a single intervention based on multiple outcomes.</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appbtab3"><div id="ch2.appb.tab3" class="table"><h3><span class="label">Table 11</span><span class="title">Rationale for downgrading quality of evidence for NMAs</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appb.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appb.tab3_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">GRADE criteria</th><th id="hd_h_ch2.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reasons for downgrading quality</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Risk of bias</td><td headers="hd_h_ch2.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Not serious: If fewer than 33.3% of the studies in the network meta-analysis were at moderate or high risk of bias, the overall network was not downgraded.</p>
|
|
<p>Serious: If greater than 33.3% of the studies in the network meta-analysis were at moderate or high risk of bias, the network was downgraded one level.</p>
|
|
<p>Very serious: If greater than 33.3% of the studies in the network meta-analysis were at high risk of bias, the network was downgraded two levels.</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Indirectness</td><td headers="hd_h_ch2.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Not serious: If fewer than 33.3% of the studies in the network meta-analysis were partially indirect or indirect, the overall network was not downgraded.</p>
|
|
<p>Serious: If greater than 33.3% of the studies in the network meta-analysis were partially indirect or indirect, the network was downgraded one level.</p>
|
|
<p>Very serious: If greater than 33.3% of the studies in the network meta-analysis were indirect, the network was downgraded two levels.</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency</td><td headers="hd_h_ch2.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>N/A: Inconsistency was marked as not applicable if there were no links in the network where data from multiple studies (either direct or indirect) were synthesised.</p>
|
|
<p>For network meta-analyses conducted under a Bayesian framework, the network was downgraded one level if the DIC for a random-effects model was lower than the DIC for a fixed-effects model.</p>
|
|
<p>In addition, the direct and indirect treatment estimates were compared as a check on the consistency of the network.</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Imprecision</td><td headers="hd_h_ch2.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This was not included in the GRADE table, but was considered during committee discussions of the evidence, taking into account 95% credible intervals around the point estimate of the effect, any relevant MIDs, committee expertise and the effect of a single intervention based on multiple outcomes.</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appctab1"><div id="ch2.appc.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appc.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appc.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Databases</th><th id="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Date searched</th><th id="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Version/files</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://onlinelibrary.wiley.com/cochranelibrary/search/quick" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cochrane Central Register of Controlled Trials (CENTRAL)</a></td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Issue 6 of 12, June 2018</td></tr><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://onlinelibrary.wiley.com/cochranelibrary/search/quick" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cochrane Database of Systematic Reviews (CDSR)</a></td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Issue 7 of 12, July 2018</td></tr><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://onlinelibrary.wiley.com/cochranelibrary/search/quick" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Database of Abstracts of Reviews of Effect (DARE)</a></td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Issue 2 of 4, April 2015</td></tr><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Embase (Ovid)</a></td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase <1974 to 2018 Week 28></td></tr><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MEDLINE (Ovid)</a></td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) ALL <1946 to July 10, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MEDLINE In-Process (Ovid)</a></td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) InProcess & Other Non-Indexed Citations <July 10, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MEDLINE Epub Ahead of Print</a></td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) Epub Ahead of Print <July 10, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MEDLINE Daily</td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) Daily Update <July 10, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PsycINFO (Ovid)</a></td><td headers="hd_h_ch2.appc.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11/07/2018</td><td headers="hd_h_ch2.appc.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid PsycINFO <1806 to July Week 1 2018></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appctab2"><div id="ch2.appc.tab2" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appc.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appc.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Databases</th><th id="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Date searched</th><th id="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Version/files</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<a href="http://onlinelibrary.wiley.com/cochranelibrary/search/quick" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cochrane Central Register of Controlled Trials (CENTRAL)</a>
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</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Issue 6 of 12, June 2018</td></tr><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="http://onlinelibrary.wiley.com/cochranelibrary/search/quick" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cochrane Database of Systematic Reviews (CDSR)</a>
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</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Issue 7 of 12, July 2018</td></tr><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="http://onlinelibrary.wiley.com/cochranelibrary/search/quick" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Database of Abstracts of Reviews of Effect (DARE)</a>
|
|
</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Issue 2 of 4, April 2015</td></tr><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Embase (Ovid)</a>
|
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</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase <1974 to 2018 Week 29></td></tr><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MEDLINE (Ovid)</a>
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</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) ALL <1946 to July 16, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MEDLINE In-Process (Ovid)</a>
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</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations <July 16, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MEDLINE Epub Ahead of Print</a>
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</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) Epub Ahead of Print <July 16, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medline daily</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) Daily Update <July 16, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PsycINFO (Ovid)</a>
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</td><td headers="hd_h_ch2.appc.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 2018</td><td headers="hd_h_ch2.appc.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PsycINFO <1806 to July Week 2 2018></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appctab3"><div id="ch2.appc.tab3" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appc.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appc.tab3_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appc.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Databases</th><th id="hd_h_ch2.appc.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Date searched</th><th id="hd_h_ch2.appc.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Version/files</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appc.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Embase (Ovid)</a></td><td headers="hd_h_ch2.appc.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Embase <1974 to 2018 Week 29></td></tr><tr><td headers="hd_h_ch2.appc.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MEDLINE (Ovid)</a></td><td headers="hd_h_ch2.appc.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 2018</td><td headers="hd_h_ch2.appc.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) ALL <1946 to July 17, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MEDLINE In-Process (Ovid)</a></td><td headers="hd_h_ch2.appc.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 2018</td><td headers="hd_h_ch2.appc.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations <July 17, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://ovidsp.uk.ovid.com/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EconLit (Ovid)</a></td><td headers="hd_h_ch2.appc.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Econlit <1886 to July 12, 2018></td></tr><tr><td headers="hd_h_ch2.appc.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://onlinelibrary.wiley.com/cochranelibrary/search/quick" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NHS Economic Evaluation Database (NHS EED) (legacy database)</a></td><td headers="hd_h_ch2.appc.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Issue 2 of 4, April 2015</td></tr><tr><td headers="hd_h_ch2.appc.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a href="http://onlinelibrary.wiley.com/cochranelibrary/search/quick" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Health Technology Assessment (HTA Database)</a></td><td headers="hd_h_ch2.appc.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18<sup>th</sup> July 18</td><td headers="hd_h_ch2.appc.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Issue 4 of 4, October 2016</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appdfig1"><div id="ch2.appd.fig1" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appdf1&p=BOOKS&id=557360_ch2appdf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appdf1.jpg" alt="Image ch2appdf1" class="tileshop" title="Click on image to zoom" /></a></div></div></article><article data-type="fig" id="figobch2appffig1"><div id="ch2.appf.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff1.jpg" alt="Figure 1. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig2"><div id="ch2.appf.fig2" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%202.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff2.jpg" alt="Figure 2. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 2</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig3"><div id="ch2.appf.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%203.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff3.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff3.jpg" alt="Figure 3. Depression symptoms (see footnotes for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 3</span><span class="title">Depression symptoms (see footnotes for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig4"><div id="ch2.appf.fig4" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%204.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff4.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff4.jpg" alt="Figure 4. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 4</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig5"><div id="ch2.appf.fig5" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%205.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff5.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff5.jpg" alt="Figure 5. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 5</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig6"><div id="ch2.appf.fig6" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%206.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff6.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff6.jpg" alt="Figure 6. Depression symptoms (see footnotes for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 6</span><span class="title">Depression symptoms (see footnotes for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig7"><div id="ch2.appf.fig7" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%207.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff7.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff7.jpg" alt="Figure 7. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 7</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig8"><div id="ch2.appf.fig8" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%208.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff8.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff8.jpg" alt="Figure 8. Depression symptoms (see footnote for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 8</span><span class="title">Depression symptoms (see footnote for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig9"><div id="ch2.appf.fig9" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%209.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff9.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff9.jpg" alt="Figure 9. Depression symptoms (see footnote for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 9</span><span class="title">Depression symptoms (see footnote for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig10"><div id="ch2.appf.fig10" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2010.%20Sensitivity%20analysis%20excluding%20studies%20with%20a%20high%20risk%20of%20bias%3A%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff10.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff10.jpg" alt="Figure 10. Sensitivity analysis excluding studies with a high risk of bias: Depression symptoms (see footnotes for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 10</span><span class="title">Sensitivity analysis excluding studies with a high risk of bias: Depression symptoms (see footnotes for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig11"><div id="ch2.appf.fig11" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2011.%20Sensitivity%20analysis%20excluding%20studies%20with%20a%20complex%20attention%20control%3A%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff11.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff11.jpg" alt="Figure 11. Sensitivity analysis excluding studies with a complex attention control: Depression symptoms (see footnotes for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 11</span><span class="title">Sensitivity analysis excluding studies with a complex attention control: Depression symptoms (see footnotes for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig12"><div id="ch2.appf.fig12" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2012.%20Depression%20symptoms%20(scale%3A%20CESD-R)%2C%20%3E6%20to%20%0226418%20months.&p=BOOKS&id=557360_ch2appff12.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff12.jpg" alt="Figure 12. Depression symptoms (scale: CESD-R), >6 to ≤18 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 12</span><span class="title">Depression symptoms (scale: CESD-R), >6 to ≤18 months</span></h3></div></article><article data-type="fig" id="figobch2appffig13"><div id="ch2.appf.fig13" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2013.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff13.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff13.jpg" alt="Figure 13. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 13</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig14"><div id="ch2.appf.fig14" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2014.%20Sensitivity%20analysis%20excluding%20studies%20with%20a%20high%20risk%20of%20bias%3A%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff14.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff14.jpg" alt="Figure 14. Sensitivity analysis excluding studies with a high risk of bias: Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 14</span><span class="title">Sensitivity analysis excluding studies with a high risk of bias: Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig15"><div id="ch2.appf.fig15" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2015.%20Sensitivity%20analysis%20excluding%20studies%20with%20a%20complex%20attention%20control%3A%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff15.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff15.jpg" alt="Figure 15. Sensitivity analysis excluding studies with a complex attention control: Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 15</span><span class="title">Sensitivity analysis excluding studies with a complex attention control: Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig16"><div id="ch2.appf.fig16" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2016.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff16.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff16.jpg" alt="Figure 16. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 16</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig17"><div id="ch2.appf.fig17" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2017.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff17.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff17.jpg" alt="Figure 17. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 17</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig18"><div id="ch2.appf.fig18" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2018.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff18.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff18.jpg" alt="Figure 18. Depression symptoms (see footnotes for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 18</span><span class="title">Depression symptoms (see footnotes for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig19"><div id="ch2.appf.fig19" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2019.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff19.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff19.jpg" alt="Figure 19. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 19</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig20"><div id="ch2.appf.fig20" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2020.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff20.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff20.jpg" alt="Figure 20. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 20</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig21"><div id="ch2.appf.fig21" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2021.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff21.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff21.jpg" alt="Figure 21. Depression symptoms (see footnotes for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 21</span><span class="title">Depression symptoms (see footnotes for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig22"><div id="ch2.appf.fig22" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2022.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20%3E6%20months%20to%20%0226418%20months.&p=BOOKS&id=557360_ch2appff22.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff22.jpg" alt="Figure 22. Depression symptoms (see footnotes for scales), >6 months to ≤18 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 22</span><span class="title">Depression symptoms (see footnotes for scales), >6 months to ≤18 months</span></h3></div></article><article data-type="fig" id="figobch2appffig23"><div id="ch2.appf.fig23" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2023.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff23.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff23.jpg" alt="Figure 23. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 23</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig24"><div id="ch2.appf.fig24" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2024.%20Functional%20status%20(scale%3A%20GAF)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff24.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff24.jpg" alt="Figure 24. Functional status (scale: GAF), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 24</span><span class="title">Functional status (scale: GAF), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig25"><div id="ch2.appf.fig25" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2025.%20Functional%20status%20(scale%3A%20GAF)%2C%20%3E6%20to%20%0226418%20months.&p=BOOKS&id=557360_ch2appff25.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff25.jpg" alt="Figure 25. Functional status (scale: GAF), >6 to ≤18 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 25</span><span class="title">Functional status (scale: GAF), >6 to ≤18 months</span></h3></div></article><article data-type="fig" id="figobch2appffig26"><div id="ch2.appf.fig26" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2026.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff26.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff26.jpg" alt="Figure 26. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 26</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig27"><div id="ch2.appf.fig27" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2027.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff27.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff27.jpg" alt="Figure 27. Depression symptoms (see footnotes for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 27</span><span class="title">Depression symptoms (see footnotes for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig28"><div id="ch2.appf.fig28" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2028.%20Depression%20symptoms%20(scale%3A%20HAM-D)%2C%20%3E6%20to%20%0226418%20months.&p=BOOKS&id=557360_ch2appff28.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff28.jpg" alt="Figure 28. Depression symptoms (scale: HAM-D), >6 to ≤18 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 28</span><span class="title">Depression symptoms (scale: HAM-D), >6 to ≤18 months</span></h3></div></article><article data-type="fig" id="figobch2appffig29"><div id="ch2.appf.fig29" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2029.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff29.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff29.jpg" alt="Figure 29. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 29</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig30"><div id="ch2.appf.fig30" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2030.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff30.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff30.jpg" alt="Figure 30. Depression symptoms (see footnote for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 30</span><span class="title">Depression symptoms (see footnote for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig31"><div id="ch2.appf.fig31" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2031.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff31.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff31.jpg" alt="Figure 31. Depression symptoms (see footnote for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 31</span><span class="title">Depression symptoms (see footnote for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig32"><div id="ch2.appf.fig32" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2032.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff32.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff32.jpg" alt="Figure 32. Depression symptoms (see footnote for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 32</span><span class="title">Depression symptoms (see footnote for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig33"><div id="ch2.appf.fig33" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2033.%20Functional%20status%20(scale%3A%20CGAS)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff33.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff33.jpg" alt="Figure 33. Functional status (scale: CGAS), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 33</span><span class="title">Functional status (scale: CGAS), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig34"><div id="ch2.appf.fig34" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2034.%20Functional%20status%20(scale%3A%20CGAS)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff34.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff34.jpg" alt="Figure 34. Functional status (scale: CGAS), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 34</span><span class="title">Functional status (scale: CGAS), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig35"><div id="ch2.appf.fig35" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2035.%20Functional%20status%20(scale%3A%20CGAS)%2C%20%3E6%20to%20%0226418%20months.&p=BOOKS&id=557360_ch2appff35.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff35.jpg" alt="Figure 35. Functional status (scale: CGAS), >6 to ≤18 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 35</span><span class="title">Functional status (scale: CGAS), >6 to ≤18 months</span></h3></div></article><article data-type="fig" id="figobch2appffig36"><div id="ch2.appf.fig36" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2036.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff36.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff36.jpg" alt="Figure 36. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 36</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig37"><div id="ch2.appf.fig37" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2037.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff37.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff37.jpg" alt="Figure 37. Depression symptoms (see footnote for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 37</span><span class="title">Depression symptoms (see footnote for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig38"><div id="ch2.appf.fig38" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2038.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20%3E6%20to%20%0226418%20months.&p=BOOKS&id=557360_ch2appff38.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff38.jpg" alt="Figure 38. Depression symptoms (see footnote for scales), >6 to ≤18 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 38</span><span class="title">Depression symptoms (see footnote for scales), >6 to ≤18 months</span></h3></div></article><article data-type="fig" id="figobch2appffig39"><div id="ch2.appf.fig39" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2039.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff39.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff39.jpg" alt="Figure 39. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 39</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig40"><div id="ch2.appf.fig40" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2040.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20%022646%20months.&p=BOOKS&id=557360_ch2appff40.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff40.jpg" alt="Figure 40. Depression symptoms (see footnote for scales), ≤6 months." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 40</span><span class="title">Depression symptoms (see footnote for scales), ≤6 months</span></h3></div></article><article data-type="fig" id="figobch2appffig41"><div id="ch2.appf.fig41" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2041.%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff41.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff41.jpg" alt="Figure 41. Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 41</span><span class="title">Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig42"><div id="ch2.appf.fig42" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2042.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff42.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff42.jpg" alt="Figure 42. Depression symptoms (see footnote for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 42</span><span class="title">Depression symptoms (see footnote for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig43"><div id="ch2.appf.fig43" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2043.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff43.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff43.jpg" alt="Figure 43. Depression symptoms (see footnote for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 43</span><span class="title">Depression symptoms (see footnote for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig44"><div id="ch2.appf.fig44" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2044.%20Sensitivity%20analysis%20excluding%20studies%20with%20a%20high%20risk%20of%20bias%3A%20Depression%20symptoms%20(see%20footnotes%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff44.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff44.jpg" alt="Figure 44. Sensitivity analysis excluding studies with a high risk of bias: Depression symptoms (see footnotes for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 44</span><span class="title">Sensitivity analysis excluding studies with a high risk of bias: Depression symptoms (see footnotes for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig45"><div id="ch2.appf.fig45" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2045.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff45.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff45.jpg" alt="Figure 45. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 45</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig46"><div id="ch2.appf.fig46" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2046.%20Sensitivity%20analysis%20excluding%20studies%20with%20a%20high%20risk%20of%20bias%3A%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff46.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff46.jpg" alt="Figure 46. Sensitivity analysis excluding studies with a high risk of bias: Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 46</span><span class="title">Sensitivity analysis excluding studies with a high risk of bias: Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig47"><div id="ch2.appf.fig47" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2047.%20Remission%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff47.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff47.jpg" alt="Figure 47. Remission, Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 47</span><span class="title">Remission, Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig48"><div id="ch2.appf.fig48" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2048.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff48.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff48.jpg" alt="Figure 48. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 48</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig49"><div id="ch2.appf.fig49" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2049.%20Depression%20symptoms%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff49.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff49.jpg" alt="Figure 49. Depression symptoms, Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 49</span><span class="title">Depression symptoms, Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig50"><div id="ch2.appf.fig50" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2050.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff50.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff50.jpg" alt="Figure 50. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 50</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig51"><div id="ch2.appf.fig51" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2051.%20Depression%20symptoms%20(scale%20%3A%20BDI)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff51.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff51.jpg" alt="Figure 51. Depression symptoms (scale : BDI), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 51</span><span class="title">Depression symptoms (scale : BDI), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig52"><div id="ch2.appf.fig52" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2052.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff52.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff52.jpg" alt="Figure 52. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 52</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig53"><div id="ch2.appf.fig53" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2053.%20Depression%20symptoms%20(scale%20%3A%20BDI)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff53.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff53.jpg" alt="Figure 53. Depression symptoms (scale : BDI), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 53</span><span class="title">Depression symptoms (scale : BDI), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig54"><div id="ch2.appf.fig54" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2054.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff54.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff54.jpg" alt="Figure 54. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 54</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="fig" id="figobch2appffig55"><div id="ch2.appf.fig55" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2055.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff55.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff55.jpg" alt="Figure 55. Depression symptoms (see footnote for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 55</span><span class="title">Depression symptoms (see footnote for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig56"><div id="ch2.appf.fig56" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2056.%20Depression%20symptoms%20(see%20footnote%20for%20scales)%2C%20Post-treatment.&p=BOOKS&id=557360_ch2appff56.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff56.jpg" alt="Figure 56. Depression symptoms (see footnote for scales), Post-treatment." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 56</span><span class="title">Depression symptoms (see footnote for scales), Post-treatment</span></h3></div></article><article data-type="fig" id="figobch2appffig57"><div id="ch2.appf.fig57" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2057.%20Discontinuation%20for%20any%20reason.&p=BOOKS&id=557360_ch2appff57.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appff57.jpg" alt="Figure 57. Discontinuation for any reason." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 57</span><span class="title">Discontinuation for any reason</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab1"><div id="ch2.appg.tab1" class="table"><h3><span class="label">Table 12</span><span class="title">Model fit statistics</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Number of Studies</th><th id="hd_h_ch2.appg.tab1_1_1_1_2" colspan="2" rowspan="1" style="text-align:center;vertical-align:middle;">Outcome</th><th id="hd_h_ch2.appg.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Model</th><th id="hd_h_ch2.appg.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Total model DIC</th><th id="hd_h_ch2.appg.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Total residual deviance</th><th id="hd_h_ch2.appg.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">No. of data-points</th><th id="hd_h_ch2.appg.tab1_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Between-study SD (95% CrI)</th><th id="hd_h_ch2.appg.tab1_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">Preferred model</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_1_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, post-treatment</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">−3</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">5 to 11 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">28.04</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5.34</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">6</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE<sup>1</sup></td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE<sup>2</sup></td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">26</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Mild</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">276.451</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">95.56</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">58</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">RE<sup>1</sup></td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">253.101</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">59.22</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">0.3391 (0.184, 0.5736)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">22</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">264.91</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">84.23</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">49</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">RE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">237.83</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">48.84</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">0.539 (0.291, 1.037)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_8_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, ≤6 months</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">22</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Mild</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">239.606</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">67.73</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">52</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE<sup>1</sup></td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">239.694</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">63.2</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">0.1283 (0.00471, 0.4706)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">5</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">54.63</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">10.35</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">11</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">54.61</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">10.35</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.996 (0.237, 9.7490)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_13_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">9</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Mild</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">85.04</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">18.15</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">22</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">87.03</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">18.79</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">0.12 (0.005, 0.496)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">4</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">39.25</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">8.36</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">9</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">39.24</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">8.34</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.963 (0.278, 9.746)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_18_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, post-treatment</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">5 to 11 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">17.33</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3.37</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">4</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">17.32</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3.36</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.976 (0.233, 9.755)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">102.88</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">19.36</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">20</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">9</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">102.91</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">19.39</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.853 (0.194, 9.727)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_23_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, ≤6 months</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">22.65</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3.37</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">4</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">22.64</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3.36</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.956 (0.239, 9.746)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_26_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">17.40</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3.37</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">4</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">17.41</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3.36</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_26_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.978 (0.229, 9.756)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_29_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Remission, post-treatment</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">5 to 11 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">35.50</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5.44</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">6</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE<sup>2</sup></td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Mild</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">21.60</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">11.56</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">4</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">21.60</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3.47</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.508 (0.126, 4.881)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">8</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">100.68</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">15.81</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">18</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">102.32</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">16.61</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">0.5614 (0.024, 3.851)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_36_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, post-treatment</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">24.56</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">6.37</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">7</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">24.50</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">6.33</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_36_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5.051 (0.2653, 9.753)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_39_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, ≤6 months</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">18.13</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.36</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">5</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">18.09</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.34</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.972 (0.241, 9.750)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1" id="hd_b_ch2.appg.tab1_1_1_42_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_42_2" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_42_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">17.62</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.35</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">5</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">17.62</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4.36</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_42_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5.028 (0.303, 9.742)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_45_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation (dichotomous), post-treatment</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">35.82</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">6.65</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">7</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">35.86</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">6.683</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_45_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2.511 (0.122, 4.870)</td></tr><tr><th headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_h_ch2.appg.tab1_1_1_1_2 hd_h_ch2.appg.tab1_1_1_1_3 hd_h_ch2.appg.tab1_1_1_1_4 hd_h_ch2.appg.tab1_1_1_1_5 hd_h_ch2.appg.tab1_1_1_1_6 hd_h_ch2.appg.tab1_1_1_1_7 hd_h_ch2.appg.tab1_1_1_1_8" id="hd_b_ch2.appg.tab1_1_1_48_1" colspan="9" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason, end point</th></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">3<sup>*</sup></td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">5 to 11 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">28.58</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5.987</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">6</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE<sup>1</sup></td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE<sup>2</sup></td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">22</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="4" colspan="1" style="text-align:left;vertical-align:middle;">12 to 18 years</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Mild</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">280.797</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">74.35</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">51</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">RE<sup>1</sup></td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">272.229</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">56.33</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">0.7805 (0.2438, 1.688)</td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_1 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">18</td><td headers="hd_h_ch2.appg.tab1_1_1_1_2 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Moderate to severe</td><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">FE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">197.60</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">38.64</td><td headers="hd_h_ch2.appg.tab1_1_1_1_6 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">41</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab1_1_1_1_8 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">FE<sup>1</sup></td></tr><tr><td headers="hd_h_ch2.appg.tab1_1_1_1_3 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RE</td><td headers="hd_h_ch2.appg.tab1_1_1_1_4 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">199.52</td><td headers="hd_h_ch2.appg.tab1_1_1_1_5 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">38.98</td><td headers="hd_h_ch2.appg.tab1_1_1_1_7 hd_b_ch2.appg.tab1_1_1_48_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">0.337 (0.017, 1.445)</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.appg.tab1_1"><p class="no_margin">Continuity correction used (0.5 was added to both arms of studies with zero events in one arm, and 1 was added to the denominator for both groups for these models).</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.appg.tab1_2"><p class="no_margin">Thin of 10 used as autocorrelation observed.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.appg.tab1_3"><p class="no_margin">Random effects model not appropriate as no data to estimate between study heterogeneity.</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobch2appgfig1"><div id="ch2.appg.fig1" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK557360/bin/ch2appgf66.jpg" alt="Figure 58. Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)." /></div><h3><span class="label">Figure 58</span><span class="title">Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig2"><div id="ch2.appg.fig2" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK557360/bin/ch2appgf1.jpg" alt="Figure 59. Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.) ." /></div><h3><span class="label">Figure 59</span><span class="title">Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)
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</span></h3></div></article><article data-type="fig" id="figobch2appgfig3"><div id="ch2.appg.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2060.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf2.jpg" alt="Figure 60. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 60</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab2"><div id="ch2.appg.tab2" class="table"><h3><span class="label">Table 13</span><span class="title">Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, post-treatment, in mild depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><th id="hd_h_ch2.appg.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><th id="hd_h_ch2.appg.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><th id="hd_h_ch2.appg.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Dance therapy</th><th id="hd_h_ch2.appg.tab2_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Guided self-help</th><th id="hd_h_ch2.appg.tab2_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group NDST</th><th id="hd_h_ch2.appg.tab2_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><th id="hd_h_ch2.appg.tab2_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab2_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group mindfulness</th><th id="hd_h_ch2.appg.tab2_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab2_1_1_1_12" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><th id="hd_h_ch2.appg.tab2_1_1_1_13" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><th id="hd_h_ch2.appg.tab2_1_1_1_14" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + computer CBT</th><th id="hd_h_ch2.appg.tab2_1_1_1_15" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><th id="hd_h_ch2.appg.tab2_1_1_1_16" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.89 (−7.71, −4.16)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−14.21 (−23.83, −4.59)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.54 (−13.17, −1.91)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.37 (−20.54, 5.89)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.34 (−4.94, 0.26)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.51 (−15.69, 6.67)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.93 (−12.05, −5.89)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.80 (−9.97, −3.93)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.73 (−3.29, 6.76)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.03 (2.34, 7.71)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.12 (0.61, 5.72)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.17 (−1.39, 0.95)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.26 (−0.95, 1.47)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.93 (−13.09, −0.78)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.95 (−6.33, 0.52)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.73 (−5.03, 1.65)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.96 (15.53, −0.45)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.13 (−8.65, 6.54)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Dance therapy</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.49 (−15.68, 0.72)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.67 (−9.29, 8.15)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.45 (10.68, 11.65)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Guided self-help</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.92 (11.85, −2.74)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.11 (−4.98, 4.23)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.03 (−7.88, 9.29)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.55 (−9.16, 9.57)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.47 (−4.16, 1.13)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.80 (−15.02, −2.58)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group NDST</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.83 (−11.03, 0.94)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.97 (−4.08, 7.89)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.11 (−6.43, 12.38)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.66 (−7.69, 12.60)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.06 (−3.96, 8.67)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.42 (−8.06, −0.78)</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.75 (−9.72, −1.90)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.04 (−2.10, 4.42)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.20 (−5.96, 10.28)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.74 (−7.37, 10.78)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.16 (−3.53, 6.51)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.92 (−7.32, 5.78)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.07 (−8.75, 0.61)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.01 (−3.28, 3.29)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.02 (−10.41, −1.75)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.79 (−2.63, 4.36)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.95 (−6.41, 10.15)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.47 (−7.85, 10.64)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.89 (−4.33, 6.78)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.18 (−7.88, 5.72)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.26 (−4.33, 3.76)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.95 (−0.61, 4.25)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.39 (−3.90, 1.04)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.90 (−8.15, 0.35)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group mindfulness</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−12.18 (−20.60, −4.04)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.36 (−13.08, 2.33)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.21 (−15.16, 6.46)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.67 (−16.56, 6.84)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.26 (−14.03, 3.96)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.33 (−17.06, 2.41)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.42 (−14.92, 1.86)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.16 (−14.69, 2.23)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.90 (−15.21, 1.31)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.07 (−7.89, 7.85)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.05 (−9.82, 11.90)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.58 (11.12, 12.23)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.05 (−8.70, 9.26)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.04 (−11.70, 7.86)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.13 (−9.26, 6.99)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.87 (−7.94, 6.19)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.28 (−5.66, 16.34)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.99 (0.87, 7.11)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.91 (−13.77, 7.82)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.90 (−6.56, 14.43)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.06 (−7.86, 17.96)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.57 (−9.04, 17.98)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.01 (−7.06, 15.65)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.93 (−9.90, 14.00)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.85 (−7.84, 13.54)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.12 (−6.82, 13.02)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.26 (−3.65, 22.36)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.98 (−3.03, 10.98)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.94 (12.79, −5.30)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.14 (−5.58, 1.40)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.99 (−9.19, 7.05)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.46 (−10.53, 7.46)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.03 (−6.95, 3.48)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.11 (−10.65, 2.61)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.19 (−6.55, 0.08)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.93 (−7.03, 1.11)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.23 (−5.20, 11.78)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.06 (−10.22, 6.08)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.04 (−16.73, 4.65)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.78 (−2.51, 4.07)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + computer CBT</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.49 (14.26, −0.95)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.69 (−6.89, 5.60)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.45 (−9.32, 10.14)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.00 (10.70, 10.42)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.59 (−7.75, 7.19)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.68 (−11.09, 5.91)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.74 (−7.99, 4.44)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.47 (−8.30, 5.28)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.67 (−5.19, 14.62)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.61 (−10.46, 9.15)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.60 (−16.60, 7.33)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.44 (−4.78, 7.70)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−10.13 (−18.93, −1.36)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.31 (−11.62, 5.16)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.18 (−13.49, 9.09)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.62 (−14.69, 9.24)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.21 (−12.32, 6.58)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.29 (−15.38, 5.07)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.37 (−13.03, 4.26)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.10 (−11.75, 3.59)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.05 (−9.30, 13.48)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.22 (−13.71, 7.18)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.21 (−19.75, 5.31)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.17 (−9.79, 7.51)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.62 (−12.85, 7.66)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab2_1_1_1_1" id="hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><td headers="hd_h_ch2.appg.tab2_1_1_1_2 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−9.46 (17.21, −2.39)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_3 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.66 (−10.30, 4.58)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_4 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.54 (−12.16, 8.58)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_5 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.98 (−13.33, 8.74)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_6 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.57 (−10.09, 5.23)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_7 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.64 (−9.17, −0.36)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_8 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.71 (−11.90, 3.94)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_9 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.46 (−11.82, 4.40)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_10 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.68 (−8.15, 13.28)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_11 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.60 (−13.59, 7.92)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_12 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.57 (−19.53, 5.92)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_13 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.53 (−8.73, 7.19)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_14 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.97 (−11.76, 7.34)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_15 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.65 (10.69, 11.55)</td><td headers="hd_h_ch2.appg.tab2_1_1_1_16 hd_b_ch2.appg.tab2_1_1_15_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig4"><div id="ch2.appg.fig4" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK557360/bin/ch2appgf67.jpg" alt="Figure 61. Diagram of the network of studies underlying the NMA for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)." /></div><h3><span class="label">Figure 61</span><span class="title">Diagram of the network of studies underlying the NMA for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig5"><div id="ch2.appg.fig5" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK557360/bin/ch2appgf3.jpg" alt="Figure 62. Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)." /></div><h3><span class="label">Figure 62</span><span class="title">Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig6"><div id="ch2.appg.fig6" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2063.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf4.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf4.jpg" alt="Figure 63. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 63</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab3"><div id="ch2.appg.tab3" class="table"><h3><span class="label">Table 14</span><span class="title">Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, ≤6 months, in mild depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab3_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><th id="hd_h_ch2.appg.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><th id="hd_h_ch2.appg.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><th id="hd_h_ch2.appg.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Self-modelling</th><th id="hd_h_ch2.appg.tab3_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Guided self-help</th><th id="hd_h_ch2.appg.tab3_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group NDST</th><th id="hd_h_ch2.appg.tab3_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><th id="hd_h_ch2.appg.tab3_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab3_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group mindfulness</th><th id="hd_h_ch2.appg.tab3_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab3_1_1_1_12" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><th id="hd_h_ch2.appg.tab3_1_1_1_13" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><th id="hd_h_ch2.appg.tab3_1_1_1_14" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + computer CBT</th><th id="hd_h_ch2.appg.tab3_1_1_1_15" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><th id="hd_h_ch2.appg.tab3_1_1_1_16" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.59 (−6.33, −2.86)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.15 (−11.27, −1.04)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.24 (−16.99, 4.51)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.09 (−2.77, 2.6)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.07 (−6.67, −1.47)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.95 (−3.03, 1.13)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.12 (−5.76, −2.47)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.38 (−1.82, 8.49)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.24 (−2.09, 12.57)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.77 (2.17, 7.45)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.61 (−1.99, 3.12)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.17 (−1.47, 1.04)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.47 (−2.77, −0.09)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.93 (−13.09, −0.69)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.43 (−5.81, 0.95)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.56 (−4.85, 1.73)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.49 (−8.20, 1.18)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.62 (−4.00, 5.23)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.44 (−5.87, 10.75)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Self-modelling</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.70 (−7.41, 6.00)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.42 (−3.21, 10.04)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.80 (−4.37, 9.94)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Guided self-help</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.35 (−2.09, 2.79)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.47 (2.06, 6.88)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.84 (−1.25, 8.95)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.05 (−5.96, 8.05)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.16 (−6.85, −1.56)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group NDST</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.90 (−6.40, −1.41)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.22 (−2.25, 2.69)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.40 (−5.51, 4.72)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.20 (−10.20, 3.82)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.24 (−6.89, −1.61)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.94 (−7.02, −2.77)</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.09 (−6.10, −2.10)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.03 (−1.15, 1.21)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.60 (−5.33, 4.17)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.39 (−10.11, 3.34)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.44 (−7.11, −1.78)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.19 (−2.91, 2.53)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.25 (−4.77, 0.17)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.03 (−3.26, 3.32)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.30 (−7.29, −3.32)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.19 (−2.41, 0.03)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.81 (−6.55, 2.95)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.61 (−11.33, 2.12)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.66 (−8.33, −2.98)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.41 (−4.13, 1.32)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.22 (−2.49, 0.06)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.63 (−23.57, 12.31)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.13 (−3.64, 1.39)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.43 (−6.67, 1.73)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group mindfulness</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.66 (12.82, −4.52)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.55 (−8.35, −0.76)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.16 (−11.14, 0.80)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.97 (15.60, −0.30)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−9.01 (13.52, −4.53)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.77 (−9.31, −0.21)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.57 (−8.55, −0.60)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.36 (−7.35, 0.64)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.30 (−4.34, −0.26)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.82 (−0.65, 4.29)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.19 (−3.87, 6.28)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.59 (−8.57, 5.38)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.65 (−5.75, 0.47)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.60 (−1.56, 4.75)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.79 (−0.88, 4.48)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.00 (0.39, 5.65)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.36 (1.84, 10.91)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.95 (−0.17, 6.07)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.62 (−3.08, 4.30)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.73 (0.79, 8.66)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.10 (−1.79, 10.04)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.31 (−6.33, 8.92)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.27 (−4.10, 4.62)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.51 (0.10, 8.89)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.69 (0.62, 8.77)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.91 (1.89, 9.96)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.27 (3.81, 14.75)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.91 (−0.15, 5.98)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.50 (−8.89, −4.09)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.37 (−4.16, −0.59)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.00 (−7.92, 1.92)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.79 (−12.66, 1.07)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.84 (−9.82, −3.87)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.60 (−5.61, 0.42)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.40 (−4.09, −0.70)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.19 (−2.89, 0.52)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.17 (−2.03, 6.36)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.19 (−7.20, −1.22)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.09 (11.37, −2.82)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.52 (−2.77, 3.81)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + computer CBT</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.27 (−8.78, −1.79)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.15 (−4.25, 1.94)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.78 (−7.33, 3.77)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.59 (−11.89, 2.77)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.62 (−9.55, −1.72)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.38 (−5.33, 2.58)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.18 (−4.28, 1.90)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.04 (−3.16, 3.20)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.39 (−1.51, 8.30)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.97 (−6.91, 0.95)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.89 (10.87, −0.90)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.22 (−1.96, 4.39)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.77 (12.40, −3.18)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.65 (−8.01, 0.69)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.28 (−10.60, 2.05)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.07 (−15.02, 0.82)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.12 (13.09, −3.21)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.87 (−8.87, 1.10)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.68 (−8.05, 0.68)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.46 (−6.65, 1.71)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.89 (−4.90, 6.71)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.47 (10.39, −0.54)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.38 (14.17, −2.59)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.28 (−5.80, 3.24)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.50 (−7.74, 2.76)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab3_1_1_1_1" id="hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><td headers="hd_h_ch2.appg.tab3_1_1_1_2 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.94 (10.98, −4.89)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_3 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.82 (−6.82, −0.79)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_4 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.45 (−9.85, 0.99)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_5 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.24 (−14.48, 0.00)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_6 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.29 (11.45, −5.13)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_7 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.04 (−5.78, −2.31)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_8 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.85 (−7.07, −0.62)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_9 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.63 (−5.86, 0.61)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_10 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.73 (−4.15, 5.58)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_11 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.64 (−9.26, −2.03)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_12 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.55 (13.27, −3.82)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_13 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.44 (−4.93, 2.05)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_14 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.66 (−6.98, 1.65)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_15 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.17 (−5.44, 5.13)</td><td headers="hd_h_ch2.appg.tab3_1_1_1_16 hd_b_ch2.appg.tab3_1_1_15_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig7"><div id="ch2.appg.fig7" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2064.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20depression%20symptoms%2C%20%3E6%20to%20%0226418%20months%2C%20in%20mild%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20IPT%3A%20interpersonal%20psychotherapy%3B%20WL%2FNTX%3A%20waiting%20list%2Fno%20treatment%3B%20NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf5.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf5.jpg" alt="Figure 64. Diagram of the network of studies underlying the NMA for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 64</span><span class="title">Diagram of the network of studies underlying the NMA for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig8"><div id="ch2.appg.fig8" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2065.%20Relative%20effectiveness%20of%20all%20options%20versus%20waiting%20list%2Fno%20treatment%20on%20the%20CDI%20scale%20for%20depression%20symptoms%2C%20%3E6%20to%20%0226418%20months%2C%20in%20mild%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%200%20favour%20waiting%20list%2Fno%20treatment%3B%20values%20lower%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf6.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf6.jpg" alt="Figure 65. Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 65</span><span class="title">Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig9"><div id="ch2.appg.fig9" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2066.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf7.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf7.jpg" alt="Figure 66. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 66</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab4"><div id="ch2.appg.tab4" class="table"><h3><span class="label">Table 15</span><span class="title">Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, <6 to ≤18 months, in mild depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab4_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><th id="hd_h_ch2.appg.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><th id="hd_h_ch2.appg.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Guided self-help</th><th id="hd_h_ch2.appg.tab4_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group NDST</th><th id="hd_h_ch2.appg.tab4_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab4_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><th id="hd_h_ch2.appg.tab4_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><th id="hd_h_ch2.appg.tab4_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + computer CBT</th><th id="hd_h_ch2.appg.tab4_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.82 (−3.99, 0.35)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.78 (−24.01, 22.53)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.77 (−5.37, −0.17)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.88 (−4.10, 0.34)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.14 (−15.77, 36.05)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.21 (−3.81, 1.3)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.73 (−0.78, 4.25)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.63 (−9.19, −2.17)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.65 (−5.03, 1.73)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.82 (−5.11, 1.47)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Guided self-help</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.61 (−3.03, 1.81)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.27 (−1.24, 3.79)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.43 (−5.11, 0.17)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group NDST</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.95 (−5.40, −0.51)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.07 (−3.58, 1.46)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.34 (−4.81, 0.13)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.78 (−3.03, 1.47)</td></tr><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.22 (−3.52, 3.06)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.66 (−0.77, 4.08)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.39 (−3.09, 3.86)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.74 (−0.77, 6.22)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.87 (−10.38, −3.35)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.99 (−7.72, −2.26)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.27 (−9.95, −2.53)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.92 (−7.62, −0.20)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.65 (−10.29, −3.01)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.29 (−5.2, −1.47)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.03 (−0.35, 6.33)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.56 (−7.10, −0.03)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.68 (−4.44, 1.07)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.96 (−6.68, 0.78)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.61 (−4.33, 3.11)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.34 (−7.00, 0.32)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.31 (1.53, 5.09)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.35 (−3.64, 2.95)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + computer CBT</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.77 (−7.79, 0.23)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.88 (−5.24, 1.44)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.16 (−7.34, 1.00)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.82 (−5.02, 3.35)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.55 (−7.68, 0.56)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.10 (−0.13, 6.32)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.21 (−3.47, 3.06)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab4_1_1_1_1" id="hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><td headers="hd_h_ch2.appg.tab4_1_1_1_2 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.49 (−6.54, −0.45)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_3 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.61 (−4.70, 1.50)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_4 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.88 (−5.95, 0.19)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_5 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.54 (−2.38, 1.28)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_6 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.28 (−7.18, 0.65)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_7 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.38 (−0.76, 7.50)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_8 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.07 (−4.05, 4.21)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_9 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.28 (−4.25, 4.85)</td><td headers="hd_h_ch2.appg.tab4_1_1_1_10 hd_b_ch2.appg.tab4_1_1_9_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig10"><div id="ch2.appg.fig10" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2067.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20remission%2C%20post-treatment%2C%20in%20mild%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy).&p=BOOKS&id=557360_ch2appgf8.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf8.jpg" alt="Figure 67. Diagram of the network of studies underlying the NMA for remission, post-treatment, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 67</span><span class="title">Diagram of the network of studies underlying the NMA for remission, post-treatment, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig11"><div id="ch2.appg.fig11" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2068.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20for%20remission%2C%20post-treatment%2C%20in%20mild%20depression%2C%2012%20to%2018%20year%20olds.%20(Relative%20risk%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20lower%20than%201%20favour%20usual%20care%3B%20values%20higher%20than%201%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf9.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf9.jpg" alt="Figure 68. Relative effectiveness of all options versus usual care for remission, post-treatment, in mild depression, 12 to 18 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour usual care; values higher than 1 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 68</span><span class="title">Relative effectiveness of all options versus usual care for remission, post-treatment, in mild depression, 12 to 18 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour usual care; values higher than 1 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig12"><div id="ch2.appg.fig12" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2069.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%203%20is%20best.).&p=BOOKS&id=557360_ch2appgf10.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf10.jpg" alt="Figure 69. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 69</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab5"><div id="ch2.appg.tab5" class="table"><h3><span class="label">Table 16</span><span class="title">Relative effectiveness of all pairwise combinations for remission, post-treatment, in mild depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs greater than 1 favour the column defining treatment, RRs less than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR greater than 1 favour the row defining treatment. RRs less than 1 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab5_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.appg.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><th id="hd_h_ch2.appg.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family therapy</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab5_1_1_1_1" id="hd_b_ch2.appg.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><td headers="hd_h_ch2.appg.tab5_1_1_1_2 hd_b_ch2.appg.tab5_1_1_1_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab5_1_1_1_3 hd_b_ch2.appg.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.67 (0.94, 7.57)</td><td headers="hd_h_ch2.appg.tab5_1_1_1_4 hd_b_ch2.appg.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.77 (0.94, 3.32)</td></tr><tr><th headers="hd_h_ch2.appg.tab5_1_1_1_1" id="hd_b_ch2.appg.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><td headers="hd_h_ch2.appg.tab5_1_1_1_2 hd_b_ch2.appg.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.54 (1.18, 6.24)</td><td headers="hd_h_ch2.appg.tab5_1_1_1_3 hd_b_ch2.appg.tab5_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab5_1_1_1_4 hd_b_ch2.appg.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab5_1_1_1_1" id="hd_b_ch2.appg.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family therapy</th><td headers="hd_h_ch2.appg.tab5_1_1_1_2 hd_b_ch2.appg.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.83 (0.98, 3.63)</td><td headers="hd_h_ch2.appg.tab5_1_1_1_3 hd_b_ch2.appg.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.73 (0.27, 1.79)</td><td headers="hd_h_ch2.appg.tab5_1_1_1_4 hd_b_ch2.appg.tab5_1_1_3_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig13"><div id="ch2.appg.fig13" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2070.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20discontinuation%2C%20endpoint%2C%20in%20mild%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20IPT%3A%20interpersonal%20psychotherapy%3B%20WL%2FNTX%3A%20waiting%20list%2Fno%20treatment%3B%20NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf11.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf11.jpg" alt="Figure 70. Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 70</span><span class="title">Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in mild depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig14"><div id="ch2.appg.fig14" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2071.%20Relative%20effectiveness%20of%20all%20options%20versus%20waiting%20list%2Fno%20treatment%20for%20discontinuation%2C%20endpoint%2C%20in%20mild%20depression%2C%2012%20to%2018%20year%20olds.%20(Relative%20risks%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%201%20favour%20waiting%20list%2Fno%20treatment%3B%20values%20lower%20than%201%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf12.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf12.jpg" alt="Figure 71. Relative effectiveness of all options versus waiting list/no treatment for discontinuation, endpoint, in mild depression, 12 to 18 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour waiting list/no treatment; values lower than 1 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 71</span><span class="title">Relative effectiveness of all options versus waiting list/no treatment for discontinuation, endpoint, in mild depression, 12 to 18 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour waiting list/no treatment; values lower than 1 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig15"><div id="ch2.appg.fig15" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2072.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf13.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf13.jpg" alt="Figure 72. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 72</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab6"><div id="ch2.appg.tab6" class="table"><h3><span class="label">Table 17</span><span class="title">Relative effectiveness of all pairwise combinations for discontinuation, endpoint, in mild depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs less than 1 favour the column defining treatment, RRs greater than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR less than 1 favour the row defining treatment. RRs greater than 1 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab6_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><th id="hd_h_ch2.appg.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><th id="hd_h_ch2.appg.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><th id="hd_h_ch2.appg.tab6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Guided self-help</th><th id="hd_h_ch2.appg.tab6_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group NDST</th><th id="hd_h_ch2.appg.tab6_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><th id="hd_h_ch2.appg.tab6_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab6_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group mindfulness</th><th id="hd_h_ch2.appg.tab6_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab6_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><th id="hd_h_ch2.appg.tab6_1_1_1_12" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><th id="hd_h_ch2.appg.tab6_1_1_1_13" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + computer CBT</th><th id="hd_h_ch2.appg.tab6_1_1_1_14" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><th id="hd_h_ch2.appg.tab6_1_1_1_15" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Creative play therapy</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Waiting list/no treatment</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.15 (0.54, 2.47)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.55 (0.63, 32.56)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.92 (1.02, 3.63)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.15 (1.15, 4.01)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.99 (0.62, 1.58)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.21 (0.01, 4.22)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.50 (0.21, 1.18)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.78 (0.37, 1.63)</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.09 (0.44, 2.16)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.37 (0.44, 4.17)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.16 (0.68, 1.96)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.30 (0.77, 2.17)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.71 (0.55, 0.93)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.42 (0.11, 1.61)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.86 (0.05, 12.5)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.79 (0.34, 9.09)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relaxation</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.37 (0.40, 5.82)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.12 (0.40, 6.99)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guided self-help</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.41 (0.31, 3.69)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.28 (0.31, 4.14)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.61 (0.11, 4.07)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.12 (0.68, 1.82)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.67 (0.48, 5.88)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group NDST</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.34 (0.39, 3.23)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.23 (0.36, 3.80)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.58 (0.13, 3.78)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.96 (0.26, 4.00)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.78 (0.42, 1.47)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Attention control</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.54 (0.11, 1.51)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.50 (0.14, 1.15)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.24 (0.04, 1.40)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.39 (0.07, 1.85)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.41 (0.07, 1.66)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.70 (0.62, 4.61)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8.50 (0.47, 153.95)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Usual care</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.66 (0.17, 1.77)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.61 (0.21, 1.45)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.29 (0.06, 1.75)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.48 (0.10, 2.36)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.50 (0.11, 2.08)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.22 (0.44, 4.39)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.74 (0.47, 1.18)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.14 (0.46, 2.82)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group mindfulness</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.96 (0.02, 5.65)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.89 (0.02, 5.83)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.43 (0.01, 4.84)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.70 (0.01, 6.92)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.72 (0.01, 6.36)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.79 (0.03, 18.54)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.45 (0.03, 13.02)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CBT</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.59 (0.12, 1.71)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.55 (0.12, 1.72)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.26 (0.04, 1.70)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.43 (0.07, 2.29)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.45 (0.08, 2.03)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.10 (0.25, 5.31)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.90 (0.25, 2.82)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.61 (0.06, 36.57)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.39 (0.40 5.00)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NDST</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.82 (0.05, 3.90)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.76 (0.05, 4.19)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.37 (0.02, 3.34)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.60 (0.03, 4.79)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.62 (0.04, 4.39)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.51 (0.11, 12.51)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.24 (0.10, 7.63)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.87 (0.03, 61.58)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.37 (0.16, 6.76)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.00 (0.24, 2.61)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.92 (0.29, 2.26)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.44 (0.08, 2.67)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.72 (0.14, 3.58)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.75 (0.15, 3.15)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.83 (0.80, 5.33)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.50 (0.49, 4.51)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.03 (0.11, 56.75)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.67 (0.40, 7.81)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.21 (0.17, 17.53)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.96 (0.25, 3.7)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group + Computer CBT</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.57 (0.20, 4.73)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.44 (0.23, 4.75)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.69 (0.08, 4.83)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.11 (0.13, 6.62)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.16 (0.14, 5.82)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.81 (0.52, 14.38)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.31 (0.37, 10.60)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.56 (0.11, 95.56)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.57 (0.34, 16.06)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.84 (0.17, 33.21)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.53 (0.28, 6.29)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group IPT</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.79 (0.18, 2.33)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.73 (0.16, 2.70)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.35 (0.06, 2.45)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.57 (0.12, 2.82)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.60 (0.19, 1.56)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.46 (0.29, 9.47)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.20 (0.23, 6.33)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.83 (0.08, 51.51)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.33 (0.24, 8.63)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.97 (0.11, 16.91)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.79 (0.15, 4.39)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.52 (0.08, 4.59)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.56 (0.63, 3.85)</td></tr><tr><th headers="hd_h_ch2.appg.tab6_1_1_1_1" id="hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Creative play therapy</th><td headers="hd_h_ch2.appg.tab6_1_1_1_2 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.95 (0.16, 3.21)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_3 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.88 (0.14, 3.92)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_4 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.42 (0.06, 3.32)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_5 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.69 (0.10, 4.26)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_6 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.72 (0.12, 3.22)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_7 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.74 (0.26, 13.31)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_8 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.43 (0.21, 9.00)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_9 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.00 (0.08, 66.41)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_10 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.59 (0.22, 11.90)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_11 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.15 (0.11, 22.56)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_12 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.95 (0.14, 6.19)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_13 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.62 (0.08, 6.16)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_14 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.19 (0.23, 5.53)</td><td headers="hd_h_ch2.appg.tab6_1_1_1_15 hd_b_ch2.appg.tab6_1_1_14_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig16"><div id="ch2.appg.fig16" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2073.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20depression%20symptoms%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%205%20to%2011%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20WL%2FNTX%3A%20waiting%20list%2Fno%20treatment%3B%20NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf14.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf14.jpg" alt="Figure 73. Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 73</span><span class="title">Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig17"><div id="ch2.appg.fig17" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2074.%20Relative%20effectiveness%20of%20all%20options%20versus%20family%20based%20IPT%20on%20the%20CDI%20scale%20for%20depression%20symptoms%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%205%20to%2011%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%200%20favour%20family%20based%20IPT%3B%20values%20lower%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf15.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf15.jpg" alt="Figure 74. Relative effectiveness of all options versus family based IPT on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour family based IPT; values lower than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 74</span><span class="title">Relative effectiveness of all options versus family based IPT on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour family based IPT; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig18"><div id="ch2.appg.fig18" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2075.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf16.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf16.jpg" alt="Figure 75. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 75</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab7"><div id="ch2.appg.tab7" class="table"><h3><span class="label">Table 18</span><span class="title">Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab7_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family based IPT</th><th id="hd_h_ch2.appg.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><th id="hd_h_ch2.appg.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family therapy</th><th id="hd_h_ch2.appg.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab7_1_1_1_1" id="hd_b_ch2.appg.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family based IPT</th><td headers="hd_h_ch2.appg.tab7_1_1_1_2 hd_b_ch2.appg.tab7_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab7_1_1_1_3 hd_b_ch2.appg.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.90 (−0.96, 10.76)</td><td headers="hd_h_ch2.appg.tab7_1_1_1_4 hd_b_ch2.appg.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab7_1_1_1_5 hd_b_ch2.appg.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab7_1_1_1_1" id="hd_b_ch2.appg.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><td headers="hd_h_ch2.appg.tab7_1_1_1_2 hd_b_ch2.appg.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.84 (−0.73, 8.40)</td><td headers="hd_h_ch2.appg.tab7_1_1_1_3 hd_b_ch2.appg.tab7_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab7_1_1_1_4 hd_b_ch2.appg.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.60 (−5.20, 0.09)</td><td headers="hd_h_ch2.appg.tab7_1_1_1_5 hd_b_ch2.appg.tab7_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab7_1_1_1_1" id="hd_b_ch2.appg.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family therapy</th><td headers="hd_h_ch2.appg.tab7_1_1_1_2 hd_b_ch2.appg.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.85 (−3.67, 7.37)</td><td headers="hd_h_ch2.appg.tab7_1_1_1_3 hd_b_ch2.appg.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.99 (−5.08, 1.11)</td><td headers="hd_h_ch2.appg.tab7_1_1_1_4 hd_b_ch2.appg.tab7_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab7_1_1_1_5 hd_b_ch2.appg.tab7_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.20 (1.45, 8.95)</td></tr><tr><th headers="hd_h_ch2.appg.tab7_1_1_1_1" id="hd_b_ch2.appg.tab7_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab7_1_1_1_2 hd_b_ch2.appg.tab7_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.05 (0.39, 13.73)</td><td headers="hd_h_ch2.appg.tab7_1_1_1_3 hd_b_ch2.appg.tab7_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.22 (−1.62, 8.07)</td><td headers="hd_h_ch2.appg.tab7_1_1_1_4 hd_b_ch2.appg.tab7_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.20 (1.46, 8.96)</td><td headers="hd_h_ch2.appg.tab7_1_1_1_5 hd_b_ch2.appg.tab7_1_1_4_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig19"><div id="ch2.appg.fig19" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2076.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20functional%20status%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%205%20to%2011%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf17.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf17.jpg" alt="Figure 76. Diagram of the network of studies underlying the NMA for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 76</span><span class="title">Diagram of the network of studies underlying the NMA for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig20"><div id="ch2.appg.fig20" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2077.%20Relative%20effectiveness%20of%20all%20options%20versus%20family%20therapy%20on%20the%20CGAS%20scale%20for%20functional%20status%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%205%20to%2011%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20lower%20than%200%20favour%20family%20therapy%3B%20values%20higher%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf18.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf18.jpg" alt="Figure 77. Relative effectiveness of all options versus family therapy on the CGAS scale for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour family therapy; values higher than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 77</span><span class="title">Relative effectiveness of all options versus family therapy on the CGAS scale for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour family therapy; values higher than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig21"><div id="ch2.appg.fig21" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2078.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%203%20is%20best.).&p=BOOKS&id=557360_ch2appgf19.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf19.jpg" alt="Figure 78. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 78</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab8"><div id="ch2.appg.tab8" class="table"><h3><span class="label">Table 19</span><span class="title">Relative effectiveness of all pairwise combinations on the GCAS scale for functional status, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs greater than 0 favour the column defining treatment, MDs less than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs greater than 0 favour the row defining treatment. MDs less than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab8_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family based IPT</th><th id="hd_h_ch2.appg.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><th id="hd_h_ch2.appg.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab8_1_1_1_1" id="hd_b_ch2.appg.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family based IPT</th><td headers="hd_h_ch2.appg.tab8_1_1_1_2 hd_b_ch2.appg.tab8_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab8_1_1_1_3 hd_b_ch2.appg.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.14 (−2.86, 3.14)</td><td headers="hd_h_ch2.appg.tab8_1_1_1_4 hd_b_ch2.appg.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.92 (−5.15, 3.31)</td></tr><tr><th headers="hd_h_ch2.appg.tab8_1_1_1_1" id="hd_b_ch2.appg.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><td headers="hd_h_ch2.appg.tab8_1_1_1_2 hd_b_ch2.appg.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.15 (−2.87, 3.16)</td><td headers="hd_h_ch2.appg.tab8_1_1_1_3 hd_b_ch2.appg.tab8_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab8_1_1_1_4 hd_b_ch2.appg.tab8_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab8_1_1_1_1" id="hd_b_ch2.appg.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab8_1_1_1_2 hd_b_ch2.appg.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.92 (−5.15, 3.35)</td><td headers="hd_h_ch2.appg.tab8_1_1_1_3 hd_b_ch2.appg.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.07 (−6.23, 4.15)</td><td headers="hd_h_ch2.appg.tab8_1_1_1_4 hd_b_ch2.appg.tab8_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig22"><div id="ch2.appg.fig22" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2079.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20remission%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%205%20to%2011%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf20.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf20.jpg" alt="Figure 79. Diagram of the network of studies underlying the NMA for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 79</span><span class="title">Diagram of the network of studies underlying the NMA for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig23"><div id="ch2.appg.fig23" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2080.%20Relative%20effectiveness%20of%20all%20options%20versus%20family%20based%20IPT%20for%20remission%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%205%20to%2011%20year%20olds.%20(Relative%20risk%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20lower%20than%201%20favour%20family%20based%20IPT%3B%20values%20higher%20than%201%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf21.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf21.jpg" alt="Figure 80. Relative effectiveness of all options versus family based IPT for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour family based IPT; values higher than 1 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 80</span><span class="title">Relative effectiveness of all options versus family based IPT for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour family based IPT; values higher than 1 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig24"><div id="ch2.appg.fig24" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2081.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%204%20is%20best.).&p=BOOKS&id=557360_ch2appgf22.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf22.jpg" alt="Figure 81. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 4 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 81</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 4 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab9"><div id="ch2.appg.tab9" class="table"><h3><span class="label">Table 20</span><span class="title">Relative effectiveness of all pairwise combinations for remission, post-treatment, in moderate to severe depression, 5 to 11 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs greater than 1 favour the column defining treatment, RRs less than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR greater than 1 favour the row defining treatment. RRs less than 1 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab9/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab9_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family based IPT</th><th id="hd_h_ch2.appg.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><th id="hd_h_ch2.appg.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family therapy</th><th id="hd_h_ch2.appg.tab9_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab9_1_1_1_1" id="hd_b_ch2.appg.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family based IPT</th><td headers="hd_h_ch2.appg.tab9_1_1_1_2 hd_b_ch2.appg.tab9_1_1_1_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab9_1_1_1_3 hd_b_ch2.appg.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.48 (0.20, 1.15)</td><td headers="hd_h_ch2.appg.tab9_1_1_1_4 hd_b_ch2.appg.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td><td headers="hd_h_ch2.appg.tab9_1_1_1_5 hd_b_ch2.appg.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab9_1_1_1_1" id="hd_b_ch2.appg.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><td headers="hd_h_ch2.appg.tab9_1_1_1_2 hd_b_ch2.appg.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.27 (0.06, 0.96)</td><td headers="hd_h_ch2.appg.tab9_1_1_1_3 hd_b_ch2.appg.tab9_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab9_1_1_1_4 hd_b_ch2.appg.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.40 (0.95, 2.06)</td><td headers="hd_h_ch2.appg.tab9_1_1_1_5 hd_b_ch2.appg.tab9_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab9_1_1_1_1" id="hd_b_ch2.appg.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family therapy</th><td headers="hd_h_ch2.appg.tab9_1_1_1_2 hd_b_ch2.appg.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.48 (0.09, 1.76)</td><td headers="hd_h_ch2.appg.tab9_1_1_1_3 hd_b_ch2.appg.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.76 (0.93, 3.32)</td><td headers="hd_h_ch2.appg.tab9_1_1_1_4 hd_b_ch2.appg.tab9_1_1_3_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab9_1_1_1_5 hd_b_ch2.appg.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.98 (0.75, 1.28)</td></tr><tr><th headers="hd_h_ch2.appg.tab9_1_1_1_1" id="hd_b_ch2.appg.tab9_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab9_1_1_1_2 hd_b_ch2.appg.tab9_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.45 (0.06, 2.11)</td><td headers="hd_h_ch2.appg.tab9_1_1_1_3 hd_b_ch2.appg.tab9_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.65 (0.49, 5.08)</td><td headers="hd_h_ch2.appg.tab9_1_1_1_4 hd_b_ch2.appg.tab9_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.94 (0.33, 2.40)</td><td headers="hd_h_ch2.appg.tab9_1_1_1_5 hd_b_ch2.appg.tab9_1_1_4_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig25"><div id="ch2.appg.fig25" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2082.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20discontinuation%2C%20endpoint%2C%20in%20moderate%20to%20severe%20depression%2C%205%20to%2011%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf23.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf23.jpg" alt="Figure 82. Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 82</span><span class="title">Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds. The thickness of the line represents the number of studies. (NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig26"><div id="ch2.appg.fig26" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2083.%20Relative%20effectiveness%20of%20all%20options%20versus%20family%20based%20IPT%20for%20discontinuation%2C%20endpoint%2C%20in%20moderate%20to%20severe%20depression%2C%205%20to%2011%20year%20olds.%20(Relative%20risks%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%201%20favour%20family%20based%20IPT%3B%20values%20lower%20than%201%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf24.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf24.jpg" alt="Figure 83. Relative effectiveness of all options versus family based IPT for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour family based IPT; values lower than 1 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 83</span><span class="title">Relative effectiveness of all options versus family based IPT for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour family based IPT; values lower than 1 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig27"><div id="ch2.appg.fig27" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2084.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.&p=BOOKS&id=557360_ch2appgf25.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf25.jpg" alt="Figure 84. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 84</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab10"><div id="ch2.appg.tab10" class="table"><h3><span class="label">Table 21</span><span class="title">Relative effectiveness of all pairwise combinations for discontinuation, endpoint, in moderate to severe depression, 5 to 11 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs less than 1 favour the column defining treatment, RRs greater than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR less than 1 favour the row defining treatment. RRs greater than 1 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab10/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab10_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family based IPT</th><th id="hd_h_ch2.appg.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><th id="hd_h_ch2.appg.tab10_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family therapy</th><th id="hd_h_ch2.appg.tab10_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab10_1_1_1_1" id="hd_b_ch2.appg.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family based IPT</th><td headers="hd_h_ch2.appg.tab10_1_1_1_2 hd_b_ch2.appg.tab10_1_1_1_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab10_1_1_1_3 hd_b_ch2.appg.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.40 (0.02, 7.69)</td><td headers="hd_h_ch2.appg.tab10_1_1_1_4 hd_b_ch2.appg.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab10_1_1_1_5 hd_b_ch2.appg.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab10_1_1_1_1" id="hd_b_ch2.appg.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><td headers="hd_h_ch2.appg.tab10_1_1_1_2 hd_b_ch2.appg.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.22 (0.00, 3.28)</td><td headers="hd_h_ch2.appg.tab10_1_1_1_3 hd_b_ch2.appg.tab10_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab10_1_1_1_4 hd_b_ch2.appg.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.60 (0.98, 6.89)</td><td headers="hd_h_ch2.appg.tab10_1_1_1_5 hd_b_ch2.appg.tab10_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab10_1_1_1_1" id="hd_b_ch2.appg.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><td headers="hd_h_ch2.appg.tab10_1_1_1_2 hd_b_ch2.appg.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.64 (0.00, 7.82)</td><td headers="hd_h_ch2.appg.tab10_1_1_1_3 hd_b_ch2.appg.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.81 (1.07, 8.80)</td><td headers="hd_h_ch2.appg.tab10_1_1_1_4 hd_b_ch2.appg.tab10_1_1_3_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab10_1_1_1_5 hd_b_ch2.appg.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.12 (0.01, 2.10)</td></tr><tr><th headers="hd_h_ch2.appg.tab10_1_1_1_1" id="hd_b_ch2.appg.tab10_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab10_1_1_1_2 hd_b_ch2.appg.tab10_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.02 (0.00, 2.29)</td><td headers="hd_h_ch2.appg.tab10_1_1_1_3 hd_b_ch2.appg.tab10_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.17 (0.00, 2.99)</td><td headers="hd_h_ch2.appg.tab10_1_1_1_4 hd_b_ch2.appg.tab10_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.06 (0.00, 0.84)</td><td headers="hd_h_ch2.appg.tab10_1_1_1_5 hd_b_ch2.appg.tab10_1_1_4_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig28"><div id="ch2.appg.fig28" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2085.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20depression%20symptoms%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20IPT%3A%20interpersonal%20psychotherapy%3B%20WL%2FNTX%3A%20waiting%20list%2Fno%20treatment%3B%20NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf26.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf26.jpg" alt="Figure 85. Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 85</span><span class="title">Diagram of the network of studies underlying the NMA for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig29"><div id="ch2.appg.fig29" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2086.%20Relative%20effectiveness%20of%20all%20options%20versus%20waiting%20list%2Fno%20treatment%20on%20the%20CDI%20scale%20for%20depression%20symptoms%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%200%20favour%20waiting%20list%2Fno%20treatment%3B%20values%20lower%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf27.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf27.jpg" alt="Figure 86. Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 86</span><span class="title">Relative effectiveness of all options versus waiting list/no treatment on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour waiting list/no treatment; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig30"><div id="ch2.appg.fig30" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2087.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf28.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf28.jpg" alt="Figure 87. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2087.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf29.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf29.jpg" alt="Figure 87. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 87</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab11"><div id="ch2.appg.tab11" class="table"><h3><span class="label">Table 22</span><span class="title">Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pairwise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab11/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab11_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab11_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><th id="hd_h_ch2.appg.tab11_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab11_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IPT-A</th><th id="hd_h_ch2.appg.tab11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Pill placebo</th><th id="hd_h_ch2.appg.tab11_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab11_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><th id="hd_h_ch2.appg.tab11_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><th id="hd_h_ch2.appg.tab11_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab11_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychosocial intevrention</th><th id="hd_h_ch2.appg.tab11_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><th id="hd_h_ch2.appg.tab11_1_1_1_12" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><th id="hd_h_ch2.appg.tab11_1_1_1_13" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><th id="hd_h_ch2.appg.tab11_1_1_1_14" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><th id="hd_h_ch2.appg.tab11_1_1_1_15" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT+parent sessions</th><th id="hd_h_ch2.appg.tab11_1_1_1_16" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Online guided self-help</th><th id="hd_h_ch2.appg.tab11_1_1_1_17" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Monitoring</th><th id="hd_h_ch2.appg.tab11_1_1_1_18" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><th id="hd_h_ch2.appg.tab11_1_1_1_19" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Behavioural activation</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="backgound-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−15.34 (−27.13, −3.55)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.12 (−10.48, −1.76)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.67 (−10.23, −3.21)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.24 (−11.27, −1.21)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.54 (−14.04, −1.04)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−9.88 (−15.66, −4.02)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.58 (−8.04, 0.88)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.08 (−4.42, 0.17)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.13 (−2.95, 5.29)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.11 (0.78, 9.53)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.51 (−1.65, 6.67)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.99 (−0.35, 4.33)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.99 (1.56, 6.33)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.15 (1.30, 11.01)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IPT-A</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−9.68 (−18.29, −1.12)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.20 (−7.96, 8.10)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.60 (−1.73, 6.93)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.51 (−2.43, 7.45)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.26 (−5.20, 5.72)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Pill placbeo</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−11.50 (−23.53, 0.72)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.61 (−12.20, 9.03)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.81 (−15.00, 11.59)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.20 (−14.16, −0.26)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.69 (−2.63, 7.87)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.50 (−5.49, 10.57)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.29 (−7.60, 16.08)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.51 (−6.41, 1.47)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.82 (−5.55, 1.82)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.12 (−7.63, 1.30)</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.95 (−18.38, −0.14)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.94 (−7.03, 8.19)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.74 (−9.78, 10.69)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.55 (−10.89, 15.15)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.76 (−9.27, 5.16)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.17 (−6.5, 2.17)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.08 (−3.90, 8.15)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−9.22 (−21.15, 2.31)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.65 (−9.91, 10.82)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.43 (−12.38, 13.18)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.24 (−12.77, 16.85)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.05 (−13.08, 8.76)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.29 (−10.51, 10.30)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.97 (−20.09, 4.27)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.90 (−8.83, 12.67)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.72 (−11.57, 15.24)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.50 (−11.65, 18.73)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.80 (−12.67, 11.26)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.96 (−11.77, 14.50)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.26 (−13.45, 16.39)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.91 (−0.43, 4.25)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychosocial intervention</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.14 (−18.35, 6.20)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.75 (−6.96, 14.56)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.54 (−9.75, 17.10)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.37 (−9.85, 20.50)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.05 (−10.88, 13.16)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.79 (−9.98, 16.45)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.09 (−11.67, 18.25)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.83 (−8.91, 12.68)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.11 (−15.37, 11.20)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.75 (−4.21, 19.66)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.55 (−6.74, 21.96)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.35 (−6.64, 25.34)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.07 (−7.98, 18.11)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.85 (−6.96, 21.39)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.11 (−8.54, 23.17)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.85 (−10.23, 21.84)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.99 (−12.11, 20.06)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Comnputer CBT</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−11.36 (−30.75, 7.58)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.49 (−20.24, 16.77)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.70 (−21.54, 17.82)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.12 (−21.44, 21.19)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.18 (−22.73, 14.02)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.40 (−19.24, 14.48)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.14 (−22.08, 17.55)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.38 (−25.16, 17.73)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.22 (−27.00, 15.86)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−9.23 (−31.59, 12.55)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.89 (1.65, 10.05)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.28 (−22.25, 9.15)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.60 (−11.63, 18.22)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.41 (−13.19, 19.56)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.23 (−13.38, 23.15)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.92 (−14.04, 15.36)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.68 (−10.17, 15.47)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.96 (−13.61, 19.38)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.73 (−17.09, 19.73)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.11 (−18.88, 17.86)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.14 (−23.64, 14.66)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.11 (−6.02, 16.09)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.74 (−14.80, −0.66)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.13 (−5.85, 10.23)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.95 (−8.13, 12.16)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.76 (−9.54, 17.06)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.55 (−8.47, 7.47)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.21 (−8.64, 11.78)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.50 (−11.11, 14.46)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.25 (−13.20, 13.61)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.58 (−15.04, 11.80)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.62 (−19.95, 8.79)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.63 (−15.85, 23.56)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.48 (−17.53, 15.22)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.52 (−4.68, 5.81)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT+ parent sessions</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.06 (−15.04, 0.77)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.81 (−6.58, 12.09)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.63 (−8.62, 13.81)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.44 (−9.86, 18.55)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.11 (−9.58, 9.73)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.88 (−9.34, 13.59)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.16 (−11.49, 15.97)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.93 (−13.38, 14.95)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.92 (−15.26, 13.19)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.94 (−20.10, 10.10)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.30 (−15.97, 24.83)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.77 (−17.76, 16.53)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.68 (−7.28, 8.45)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Online guided self-help</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.32 (−20.64, 4.05)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.58 (−12.04, 15.17)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.41 (−13.58, 16.35)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.19 (−14.22, 20.29)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.10 (−15.24, 13.00)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.67 (−14.50, 16.21)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.92 (−15.98, 18.04)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.32 (−17.75, 16.94)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.16 (−19.64, 15.18)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.18 (−24.35, 11.93)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.10 (−19.51, 26.06)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.03 (−21.81, 18.23)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.56 (−14.79, 13.61)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.24 (−15.84, 13.49)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Monitoring</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.17 (−21.42, 7.17)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.71 (−11.44, 16.67)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.50 (−9.05, 14.09)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.33 (−13.38, 21.86)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.03 (−14.00, 13.98)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.80 (−13.38, 17.52)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.09 (−15.01, 19.35)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.80 (−16.99, 18.32)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.04 (−18.86, 16.49)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.04 (−23.56, 13.39)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.20 (−18.42, 27.25)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.89 (−20.67, 19.33)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.55 (−14.74, 15.91)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.12 (−16.12, 16.05)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.12 (−17.70, 20.03)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−9.37 (−24.25, 5.45)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.54 (−14.11, 14.98)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.34 (−11.77, 12.39)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.12 (−16.03, 20.13)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.17 (−16.69, 12.39)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.38 (−15.99, 15.70)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.12 (−17.67, 17.60)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.40 (−19.49, 16.62)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.26 (−21.43, 14.92)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−7.23 (−26.07, 11.40)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.97 (−20.78, 25.31)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.09 (−23.19, 17.68)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.63 (−17.52, 14.10)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.30 (−18.70, 14.32)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.06 (−20.27, 18.25)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.18 (−18.85, 14.51)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab11_1_1_1_1" id="hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Behavioural activation</th><td headers="hd_h_ch2.appg.tab11_1_1_1_2 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−11.31 (−25.10, 2.35)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_3 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.43 (−14.45, 11.45)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_4 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.61 (−15.92, 12.61)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_5 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.14 (−16.59, 16.88)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_6 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.13 (−16.01, 7.73)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_7 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.37 (−16.05, 11.78)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_8 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.08 (−18.08, 14.16)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_9 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.32 (−20.24, 13.35)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_10 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.19 (−22.05, 11.59)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_11 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−9.19 (−26.84, 8.41)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_12 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.05 (−21.61, 22.16)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_13 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.04 (−23.81, 14.10)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_14 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.56 (−17.89, 10.51)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_15 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.24 (−19.49, 10.95)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_16 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.98 (−21.51, 15.33)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_17 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.14 (−22.51, 14.13)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_18 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.92 (−20.71, 16.67)</td><td headers="hd_h_ch2.appg.tab11_1_1_1_19 hd_b_ch2.appg.tab11_1_1_18_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig31"><div id="ch2.appg.fig31" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2088.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20depression%20symptoms%2C%20%022646%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20IPT%3A%20interpersonal%20psychotherapy).&p=BOOKS&id=557360_ch2appgf30.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf30.jpg" alt="Figure 88. Diagram of the network of studies underlying the NMA for depression symptoms, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 88</span><span class="title">Diagram of the network of studies underlying the NMA for depression symptoms, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig32"><div id="ch2.appg.fig32" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2089.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20on%20the%20CDI%20scale%20for%20depression%20symptoms%2C%20%022646%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%200%20favour%20usual%20care%3B%20values%20lower%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf31.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf31.jpg" alt="Figure 89. Relative effectiveness of all options versus usual care on the CDI scale for depression symptoms, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 89</span><span class="title">Relative effectiveness of all options versus usual care on the CDI scale for depression symptoms, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig33"><div id="ch2.appg.fig33" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2090.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf32.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf32.jpg" alt="Figure 90. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 90</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab12"><div id="ch2.appg.tab12" class="table"><h3><span class="label">Table 23</span><span class="title">Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, .6 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab12/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab12_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab12_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychosocial intervention</th><th id="hd_h_ch2.appg.tab12_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxatio</th><th id="hd_h_ch2.appg.tab12_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><th id="hd_h_ch2.appg.tab12_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IPT-A</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab12_1_1_1_1" id="hd_b_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab12_1_1_1_2 hd_b_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab12_1_1_1_3 hd_b_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.95 (−3.29, 1.39)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_4 hd_b_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_5 hd_b_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_6 hd_b_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_7 hd_b_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.17 (−4.07, 4.42)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_8 hd_b_ch2.appg.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab12_1_1_1_1" id="hd_b_ch2.appg.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab12_1_1_1_2 hd_b_ch2.appg.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.95 (−3.28, 1.37)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_3 hd_b_ch2.appg.tab12_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab12_1_1_1_4 hd_b_ch2.appg.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.69 (−2.95, 1.56)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_5 hd_b_ch2.appg.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (−2.25, 2.34)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_6 hd_b_ch2.appg.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.04 (−3.90, 5.98)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_7 hd_b_ch2.appg.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_8 hd_b_ch2.appg.tab12_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.76 (−2.63, 10.15)</td></tr><tr><th headers="hd_h_ch2.appg.tab12_1_1_1_1" id="hd_b_ch2.appg.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab12_1_1_1_2 hd_b_ch2.appg.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.62 (−4.80, 1.58)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_3 hd_b_ch2.appg.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.67 (−2.85, 1.52)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_4 hd_b_ch2.appg.tab12_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab12_1_1_1_5 hd_b_ch2.appg.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.78 (−1.56, 3.12)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_6 hd_b_ch2.appg.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_7 hd_b_ch2.appg.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_8 hd_b_ch2.appg.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab12_1_1_1_1" id="hd_b_ch2.appg.tab12_1_1_4_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">Psychosocial intervention</th><td headers="hd_h_ch2.appg.tab12_1_1_1_2 hd_b_ch2.appg.tab12_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.90 (−4.11, 2.31)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_3 hd_b_ch2.appg.tab12_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.05 (−2.17, 2.28)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_4 hd_b_ch2.appg.tab12_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.72 (−1.38, 2.83)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_5 hd_b_ch2.appg.tab12_1_1_4_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab12_1_1_1_6 hd_b_ch2.appg.tab12_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_7 hd_b_ch2.appg.tab12_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_8 hd_b_ch2.appg.tab12_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab12_1_1_1_1" id="hd_b_ch2.appg.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">Relaxation</th><td headers="hd_h_ch2.appg.tab12_1_1_1_2 hd_b_ch2.appg.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.42 (−6.41, 7.33)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_3 hd_b_ch2.appg.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.38 (−5.06, 7.84)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_4 hd_b_ch2.appg.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.05 (−4.77, 8.88)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_5 hd_b_ch2.appg.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.33 (−5.48, 8.16)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_6 hd_b_ch2.appg.tab12_1_1_5_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab12_1_1_1_7 hd_b_ch2.appg.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab12_1_1_1_8 hd_b_ch2.appg.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab12_1_1_1_1" id="hd_b_ch2.appg.tab12_1_1_6_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">Family therapy</th><td headers="hd_h_ch2.appg.tab12_1_1_1_2 hd_b_ch2.appg.tab12_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.17 (−3.99, 4.35)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_3 hd_b_ch2.appg.tab12_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.12 (−3.65, 5.89)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_4 hd_b_ch2.appg.tab12_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.79 (−3.44, 7.03)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_5 hd_b_ch2.appg.tab12_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.06 (−4.16, 6.32)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_6 hd_b_ch2.appg.tab12_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.26 (−8.31, 7.77)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_7 hd_b_ch2.appg.tab12_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab12_1_1_1_8 hd_b_ch2.appg.tab12_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab12_1_1_1_1" id="hd_b_ch2.appg.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">IPT-A</th><td headers="hd_h_ch2.appg.tab12_1_1_1_2 hd_b_ch2.appg.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.80 (−4.01, 9.64)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_3 hd_b_ch2.appg.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.76 (−2.65, 10.16)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_4 hd_b_ch2.appg.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.42 (−2.36, 11.18)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_5 hd_b_ch2.appg.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.70 (−3.08, 10.49)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_6 hd_b_ch2.appg.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.36 (−6.67, 11.48)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_7 hd_b_ch2.appg.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.63 (−5.33, 10.62)</td><td headers="hd_h_ch2.appg.tab12_1_1_1_8 hd_b_ch2.appg.tab12_1_1_7_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig34"><div id="ch2.appg.fig34" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2091.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20depression%20symptoms%2C%20%3E6%20to%20%0226418%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy).&p=BOOKS&id=557360_ch2appgf33.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf33.jpg" alt="Figure 91. Diagram of the network of studies underlying the NMA for depression symptoms, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 91</span><span class="title">Diagram of the network of studies underlying the NMA for depression symptoms, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig35"><div id="ch2.appg.fig35" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2092.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20on%20the%20CDI%20scale%20for%20depression%20symptoms%2C%20%3E6%20to%20%0226418%20months%2C%20in%20mild%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%200%20favour%20usual%20care%3B%20values%20lower%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf34.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf34.jpg" alt="Figure 92. Relative effectiveness of all options versus usual care on the CDI scale for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 92</span><span class="title">Relative effectiveness of all options versus usual care on the CDI scale for depression symptoms, >6 to ≤18 months, in mild depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig36"><div id="ch2.appg.fig36" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2093.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf35.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf35.jpg" alt="Figure 93. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 93</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab13"><div id="ch2.appg.tab13" class="table"><h3><span class="label">Table 24</span><span class="title">Relative effectiveness of all pairwise combinations on the CDI scale for depression symptoms, <6 to ≤18 months, in mild depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab13/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab13_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab13_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab13_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab13_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab13_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychosocial intervention</th><th id="hd_h_ch2.appg.tab13_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><th id="hd_h_ch2.appg.tab13_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + parent sessions</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab13_1_1_1_1" id="hd_b_ch2.appg.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab13_1_1_1_2 hd_b_ch2.appg.tab13_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab13_1_1_1_3 hd_b_ch2.appg.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.21 (−3.55, 1.13)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_4 hd_b_ch2.appg.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab13_1_1_1_5 hd_b_ch2.appg.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab13_1_1_1_6 hd_b_ch2.appg.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.69 (−3.29, 4.68)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_7 hd_b_ch2.appg.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab13_1_1_1_1" id="hd_b_ch2.appg.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab13_1_1_1_2 hd_b_ch2.appg.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.20 (−3.51, 1.13)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_3 hd_b_ch2.appg.tab13_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab13_1_1_1_4 hd_b_ch2.appg.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.17 (−1.99, 2.43)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_5 hd_b_ch2.appg.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.78 (−1.39, 3.03)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_6 hd_b_ch2.appg.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab13_1_1_1_7 hd_b_ch2.appg.tab13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab13_1_1_1_1" id="hd_b_ch2.appg.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab13_1_1_1_2 hd_b_ch2.appg.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.00 (−4.20, 2.19)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_3 hd_b_ch2.appg.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.19 (−1.99, 2.36)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_4 hd_b_ch2.appg.tab13_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab13_1_1_1_5 hd_b_ch2.appg.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.61 (−1.65, 2.86)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_6 hd_b_ch2.appg.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab13_1_1_1_7 hd_b_ch2.appg.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab13_1_1_1_1" id="hd_b_ch2.appg.tab13_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychosocial intervention</th><td headers="hd_h_ch2.appg.tab13_1_1_1_2 hd_b_ch2.appg.tab13_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.38 (−3.60, 2.84)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_3 hd_b_ch2.appg.tab13_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.80 (−1.41, 3.02)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_4 hd_b_ch2.appg.tab13_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.62 (−1.62, 2.87)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_5 hd_b_ch2.appg.tab13_1_1_4_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab13_1_1_1_6 hd_b_ch2.appg.tab13_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab13_1_1_1_7 hd_b_ch2.appg.tab13_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab13_1_1_1_1" id="hd_b_ch2.appg.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><td headers="hd_h_ch2.appg.tab13_1_1_1_2 hd_b_ch2.appg.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.68 (−3.25, 4.59)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_3 hd_b_ch2.appg.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.87 (−2.70, 6.42)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_4 hd_b_ch2.appg.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.68 (−3.40, 6.73)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_5 hd_b_ch2.appg.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.07 (−4.04, 6.13)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_6 hd_b_ch2.appg.tab13_1_1_5_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab13_1_1_1_7 hd_b_ch2.appg.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.04 (−7.37, 5.29)</td></tr><tr><th headers="hd_h_ch2.appg.tab13_1_1_1_1" id="hd_b_ch2.appg.tab13_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + parent sessions</th><td headers="hd_h_ch2.appg.tab13_1_1_1_2 hd_b_ch2.appg.tab13_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.34 (−7.60, 6.90)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_3 hd_b_ch2.appg.tab13_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.86 (−6.76, 8.44)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_4 hd_b_ch2.appg.tab13_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.67 (−7.22, 8.55)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_5 hd_b_ch2.appg.tab13_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.05 (−7.87, 7.95)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_6 hd_b_ch2.appg.tab13_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.02 (−7.11, 5.05)</td><td headers="hd_h_ch2.appg.tab13_1_1_1_7 hd_b_ch2.appg.tab13_1_1_6_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig37"><div id="ch2.appg.fig37" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2094.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20functional%20status%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20IPT%3A%20interpersonal%20psychotherapy%3B%20WL%2FNTX%3A%20waiting%20list%2Fno%20treatment%3B%20NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf36.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf36.jpg" alt="Figure 94. Diagram of the network of studies underlying the NMA for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 94</span><span class="title">Diagram of the network of studies underlying the NMA for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; IPT: interpersonal psychotherapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig38"><div id="ch2.appg.fig38" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2095.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20on%20the%20CGAS%20scale%20for%20functional%20status%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20lower%20than%200%20favour%20usual%20care%3B%20values%20higher%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf37.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf37.jpg" alt="Figure 95. Relative effectiveness of all options versus usual care on the CGAS scale for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour usual care; values higher than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 95</span><span class="title">Relative effectiveness of all options versus usual care on the CGAS scale for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour usual care; values higher than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig39"><div id="ch2.appg.fig39" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2096.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%2013%20is%20best.).&p=BOOKS&id=557360_ch2appgf38.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf38.jpg" alt="Figure 96. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 13 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 96</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 13 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab14"><div id="ch2.appg.tab14" class="table"><h3><span class="label">Table 25</span><span class="title">Relative effectiveness of all pairwise combinations on the CGAS scale for functional status, post-treatment, in moderate to severe depression, 12 to 18 year olds.(Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs greater than 0 favour the column defining treatment, MDs less than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs greater than 0 favour the row defining treatment. MDs less than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab14/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab14_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Pill placebo</th><th id="hd_h_ch2.appg.tab14_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><th id="hd_h_ch2.appg.tab14_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><th id="hd_h_ch2.appg.tab14_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><th id="hd_h_ch2.appg.tab14_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><th id="hd_h_ch2.appg.tab14_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><th id="hd_h_ch2.appg.tab14_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + parent sessions</th><th id="hd_h_ch2.appg.tab14_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IPT-A</th><th id="hd_h_ch2.appg.tab14_1_1_1_12" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><th id="hd_h_ch2.appg.tab14_1_1_1_13" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Behavioural activation</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.27 (1.99, 6.55)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.42 (−2.56, 5.5)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.30 (1.37, 13.23)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.00 (−2.61, 8.61)</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.27 (2.00, 6.55)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.20 (−2.58, 2.98)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.40 (−1.81, 6.61)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.40 (−4.05, 4.85)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.6 (−8.81, 1.52)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Pill placebo</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.46 (0.89, 8.04)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.19 (−2.59, 2.98)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.67 (1.92, 11.47)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.40 (−1.80, 6.62)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.21 (−2.84, 7.26)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.00 (−6.29, 2.29)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.67 (−0.30, 9.69)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.40 (−4.04, 4.85)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.21 (−5.07, 5.47)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.00 (−6.32, 2.28)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.64 (−4.91, 6.21)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.63 (−8.71, 1.45)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.83 (−9.60, 1.95)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.05 (−12.58, 0.58)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.04 (−10.79, 2.72)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.43 (−2.57, 5.44)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.84 (−7.44, 1.78)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.03 (−8.37, 2.32)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.23 (−11.54, 1.00)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.23 (−9.68, 3.18)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.80 (−6.02, 7.63)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.98 (−8.81, 0.76)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.98 (−0.57, 8.53)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.30 (−8.20, 3.58)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.59 (−12.87, −0.26)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.77 (−13.66, 0.12)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−8.97 (−16.60, −1.41)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.97 (−14.76, 0.75)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.95 (−10.99, 5.15)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.75 (−8.03, 0.57)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.39 (2.37, 12.41)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + parent sessions</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.58 (−0.61, 11.81)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.31 (−5.28, 7.93)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.11 (−6.03, 8.26)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.09 (−8.95, 6.75)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.91 (−7.09, 8.89)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.94 (−3.33, 13.22)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.15 (−0.57, 8.86)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.89 (2.86, 12.91)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IPT-A</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.30 (1.28, 13.24)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.02 (−3.38, 9.38)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.82 (−4.15, 9.72)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.63 (−7.12, 8.20)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.63 (−5.19, 10.35)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6.64 (−1.52, 14.80)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.85 (−1.35, 13.05)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9.59 (1.21, 18.00)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.69 (−6.90, 10.29)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.95 (−16.27, 2.37)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.31 (−10.83, 11.49)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.96 (−15.28, 7.43)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.15 (−15.81, 7.54)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.36 (−18.43, 5.79)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.37 (−16.51, 7.87)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.34 (−12.72, 12.11)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.12 (−12.98, 10.72)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.61 (−10.00, 15.33)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−5.27 (−18.04, 7.53)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−6.96 (−16.35, 2.43)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab14_1_1_1_1" id="hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Behavioural activation</th><td headers="hd_h_ch2.appg.tab14_1_1_1_2 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.99 (−2.58, 8.57)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_3 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.28 (−7.31, 4.73)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_4 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.47 (−8.10, 5.16)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_5 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−3.68 (−11.04, 3.66)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_6 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.67 (−9.19, 5.83)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_7 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.37 (−5.57, 10.21)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_8 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.55 (−5.29, 8.43)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_9 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.30 (−2.78, 13.40)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_10 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.58 (−10.89, 5.75)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_11 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−4.28 (−12.44, 3.86)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_12 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.68 (−9.84, 15.12)</td><td headers="hd_h_ch2.appg.tab14_1_1_1_13 hd_b_ch2.appg.tab14_1_1_12_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig40"><div id="ch2.appg.fig40" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2097.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20functional%20status%2C%20%022646%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy).&p=BOOKS&id=557360_ch2appgf39.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf39.jpg" alt="Figure 97. Diagram of the network of studies underlying the NMA for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 97</span><span class="title">Diagram of the network of studies underlying the NMA for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig41"><div id="ch2.appg.fig41" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2098.%20Relative%20effectiveness%20of%20all%20options%20versus%20CBT%20on%20the%20CGAS%20scale%20for%20functional%20status%2C%20%022646%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20lower%20than%200%20favour%20CBT%3B%20values%20higher%20than%200%20favour%20the%20other%20treatments).&p=BOOKS&id=557360_ch2appgf40.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf40.jpg" alt="Figure 98. Relative effectiveness of all options versus CBT on the CGAS scale for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour CBT; values higher than 0 favour the other treatments)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 98</span><span class="title">Relative effectiveness of all options versus CBT on the CGAS scale for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour CBT; values higher than 0 favour the other treatments)</span></h3></div></article><article data-type="fig" id="figobch2appgfig42"><div id="ch2.appg.fig42" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%2099.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%203%20is%20best.).&p=BOOKS&id=557360_ch2appgf41.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf41.jpg" alt="Figure 99. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 99</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab15"><div id="ch2.appg.tab15" class="table"><h3><span class="label">Table 26</span><span class="title">Relative effectiveness of all pairwise combinations on the CGAS scale for functional status, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs greater than 0 favour the column defining treatment, MDs less than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs greater than 0 favour the row defining treatment. MDs less than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab15/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab15_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><th id="hd_h_ch2.appg.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.appg.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Relaxation</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab15_1_1_1_1" id="hd_b_ch2.appg.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><td headers="hd_h_ch2.appg.tab15_1_1_1_2 hd_b_ch2.appg.tab15_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab15_1_1_1_3 hd_b_ch2.appg.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.84 (−4.17, 0.49)</td><td headers="hd_h_ch2.appg.tab15_1_1_1_4 hd_b_ch2.appg.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.52 (−6.92, 3.79)</td></tr><tr><th headers="hd_h_ch2.appg.tab15_1_1_1_1" id="hd_b_ch2.appg.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><td headers="hd_h_ch2.appg.tab15_1_1_1_2 hd_b_ch2.appg.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.83 (−0.50, 4.17)</td><td headers="hd_h_ch2.appg.tab15_1_1_1_3 hd_b_ch2.appg.tab15_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab15_1_1_1_4 hd_b_ch2.appg.tab15_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab15_1_1_1_1" id="hd_b_ch2.appg.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Relaxation</th><td headers="hd_h_ch2.appg.tab15_1_1_1_2 hd_b_ch2.appg.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.30 (−5.47, 6.07)</td><td headers="hd_h_ch2.appg.tab15_1_1_1_3 hd_b_ch2.appg.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.53 (−6.84, 3.75)</td><td headers="hd_h_ch2.appg.tab15_1_1_1_4 hd_b_ch2.appg.tab15_1_1_3_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig43"><div id="ch2.appg.fig43" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20100.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20functional%20status%2C%20%3E6%20to%20%0226418%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy).&p=BOOKS&id=557360_ch2appgf42.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf42.jpg" alt="Figure 100. Diagram of the network of studies underlying the NMA for functional status, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 100</span><span class="title">Diagram of the network of studies underlying the NMA for functional status, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig44"><div id="ch2.appg.fig44" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20101.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20on%20the%20CGAS%20scale%20for%20functional%20status%2C%20%3E6%20to%20%0226418%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20lower%20than%200%20favour%20usual%20care%3B%20values%20higher%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf43.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf43.jpg" alt="Figure 101. Relative effectiveness of all options versus usual care on the CGAS scale for functional status, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour usual care; values higher than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 101</span><span class="title">Relative effectiveness of all options versus usual care on the CGAS scale for functional status, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values lower than 0 favour usual care; values higher than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig45"><div id="ch2.appg.fig45" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20102.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%203%20is%20best.).&p=BOOKS&id=557360_ch2appgf44.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf44.jpg" alt="Figure 102. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 102</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 3 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab16"><div id="ch2.appg.tab16" class="table"><h3><span class="label">Table 27</span><span class="title">Relative effectiveness of all pairwise combinations on the CGAS scale for functional status, <6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs greater than 0 favour the column defining treatment, MDs less than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs greater than 0 favour the row defining treatment. MDs less than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab16/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab16_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.appg.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><th id="hd_h_ch2.appg.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Group CBT</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab16_1_1_1_1" id="hd_b_ch2.appg.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><td headers="hd_h_ch2.appg.tab16_1_1_1_2 hd_b_ch2.appg.tab16_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab16_1_1_1_3 hd_b_ch2.appg.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.03 (−2.62, 2.56)</td><td headers="hd_h_ch2.appg.tab16_1_1_1_4 hd_b_ch2.appg.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.47 (−4.83, 3.88)</td></tr><tr><th headers="hd_h_ch2.appg.tab16_1_1_1_1" id="hd_b_ch2.appg.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><td headers="hd_h_ch2.appg.tab16_1_1_1_2 hd_b_ch2.appg.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.02 (−2.63, 2.59)</td><td headers="hd_h_ch2.appg.tab16_1_1_1_3 hd_b_ch2.appg.tab16_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab16_1_1_1_4 hd_b_ch2.appg.tab16_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab16_1_1_1_1" id="hd_b_ch2.appg.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Group CBT</th><td headers="hd_h_ch2.appg.tab16_1_1_1_2 hd_b_ch2.appg.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.42 (−4.80, 3.92)</td><td headers="hd_h_ch2.appg.tab16_1_1_1_3 hd_b_ch2.appg.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.41 (−5.50, 4.66)</td><td headers="hd_h_ch2.appg.tab16_1_1_1_4 hd_b_ch2.appg.tab16_1_1_3_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig46"><div id="ch2.appg.fig46" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20103.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20remission%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf45.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf45.jpg" alt="Figure 103. Diagram of the network of studies underlying the NMA for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 103</span><span class="title">Diagram of the network of studies underlying the NMA for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig47"><div id="ch2.appg.fig47" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20104.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20for%20remission%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.(Relative%20risk%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20lower%20than%201%20favour%20usual%20care%3B%20values%20higher%20than%201%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf46.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf46.jpg" alt="Figure 104. Relative effectiveness of all options versus usual care for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds.(Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour usual care; values higher than 1 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 104</span><span class="title">Relative effectiveness of all options versus usual care for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds.(Relative risk with 95% credible intervals and line of no effect in red; values lower than 1 favour usual care; values higher than 1 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig48"><div id="ch2.appg.fig48" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20105.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%209%20is%20best).&p=BOOKS&id=557360_ch2appgf47.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf47.jpg" alt="Figure 105. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 9 is best)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 105</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 9 is best)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab17"><div id="ch2.appg.tab17" class="table"><h3><span class="label">Table 28</span><span class="title">Relative effectiveness of all pairwise combinations for remission, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs greater than 1 favour the column defining treatment, RRs less than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR greater than 1 favour the row defining treatment. RRs less than 1 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab17/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab17_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab17_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab17_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab17_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><th id="hd_h_ch2.appg.tab17_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><th id="hd_h_ch2.appg.tab17_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab17_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychosocial intervention</th><th id="hd_h_ch2.appg.tab17_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><th id="hd_h_ch2.appg.tab17_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><th id="hd_h_ch2.appg.tab17_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.05 (0.57, 1.93)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.04 (0.47, 1.70)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.48 (0.26, 0.89)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.79 (0.65, 0.96)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.97 (0.69, 1.35)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.96 (0.69, 1.33)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.38 (0.16, 0.91)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Family therapy</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.46 (0.11, 1.20)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.45 (0.17, 0.88)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.25 (0.61, 2.56)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.33 (0.11, 1.01)</td></tr><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.63 (0.19, 1.33)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.61 (0.32, 0.93)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.33 (0.68, 3.16)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.02 (0.42, 1.72)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.98 (0.72, 1.24)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.13 (1.07, 6.02)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.58 (0.98, 3.25)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.99 (0.71, 1.39)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.02 (0.42, 1.71)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.97 (0.72, 1.24)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.12 (1.07, 5.96)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.57 (0.98, 3.22)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.00 (0.76, 1.31)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relaxation</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.36 (0.07, 1.14)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.36 (0.09, 0.87)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.80 (0.19, 2.77)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.60 (0.15, 1.64)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.37 (0.09, 0.92)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.37 (0.09, 0.93)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.82 (0.08, 2.01)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.79 (0.11, 1.98)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.63 (0.31, 5.49)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.25 (0.19, 4.07)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.82 (0.11, 2.16)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.82 (0.11, 2.17)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.04 (0.26, 11.99)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.18 (0.07, 0.47)</td></tr><tr><th headers="hd_h_ch2.appg.tab17_1_1_1_1" id="hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attention control</th><td headers="hd_h_ch2.appg.tab17_1_1_1_2 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (0.01, 0.62)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_3 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (0.01, 0.50)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_4 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.21 (0.03, 0.83)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_5 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.15 (0.02, 0.76)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_6 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (0.01, 0.52)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_7 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (0.01, 0.52)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_8 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.26 (0.03, 1.90)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_9 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.13 (0.04, 0.40)</td><td headers="hd_h_ch2.appg.tab17_1_1_1_10 hd_b_ch2.appg.tab17_1_1_9_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig49"><div id="ch2.appg.fig49" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20106.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20quality%20of%20life%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy).&p=BOOKS&id=557360_ch2appgf48.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf48.jpg" alt="Figure 106. Diagram of the network of studies underlying the NMA for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 106</span><span class="title">Diagram of the network of studies underlying the NMA for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig50"><div id="ch2.appg.fig50" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20107.%20Relative%20effectiveness%20of%20all%20options%20versus%20pill%20placebo%20on%20the%20HoNOSCA%20scale%20for%20quality%20of%20life%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%200%20favour%20pill%20placebo%3B%20values%20lower%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf49.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf49.jpg" alt="Figure 107. Relative effectiveness of all options versus pill placebo on the HoNOSCA scale for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour pill placebo; values lower than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 107</span><span class="title">Relative effectiveness of all options versus pill placebo on the HoNOSCA scale for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour pill placebo; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig51"><div id="ch2.appg.fig51" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20108.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf50.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf50.jpg" alt="Figure 108. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 108</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab18"><div id="ch2.appg.tab18" class="table"><h3><span class="label">Table 29</span><span class="title">Relative effectiveness of all pairwise combinations on the HoNOSCA scale for quality of life, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab18/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab18_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab18_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Pill placebo</th><th id="hd_h_ch2.appg.tab18_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><th id="hd_h_ch2.appg.tab18_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.appg.tab18_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab18_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychosocial intervention</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab18_1_1_1_1" id="hd_b_ch2.appg.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Pill placebo</th><td headers="hd_h_ch2.appg.tab18_1_1_1_2 hd_b_ch2.appg.tab18_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab18_1_1_1_3 hd_b_ch2.appg.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.90 (−0.90, 2.70)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_4 hd_b_ch2.appg.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab18_1_1_1_5 hd_b_ch2.appg.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab18_1_1_1_6 hd_b_ch2.appg.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab18_1_1_1_1" id="hd_b_ch2.appg.tab18_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><td headers="hd_h_ch2.appg.tab18_1_1_1_2 hd_b_ch2.appg.tab18_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.90 (−0.89, 2.71)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_3 hd_b_ch2.appg.tab18_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab18_1_1_1_4 hd_b_ch2.appg.tab18_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.85 (1.1, 4.6)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_5 hd_b_ch2.appg.tab18_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.80 (−1.27, 2.87)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_6 hd_b_ch2.appg.tab18_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.80 (−0.37, 3.97)</td></tr><tr><th headers="hd_h_ch2.appg.tab18_1_1_1_1" id="hd_b_ch2.appg.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><td headers="hd_h_ch2.appg.tab18_1_1_1_2 hd_b_ch2.appg.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.75 (1.26, 6.25)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_3 hd_b_ch2.appg.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.85 (1.11, 4.59)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_4 hd_b_ch2.appg.tab18_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab18_1_1_1_5 hd_b_ch2.appg.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab18_1_1_1_6 hd_b_ch2.appg.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab18_1_1_1_1" id="hd_b_ch2.appg.tab18_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab18_1_1_1_2 hd_b_ch2.appg.tab18_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.71 (−1.04, 4.44)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_3 hd_b_ch2.appg.tab18_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.81 (−1.28, 2.88)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_4 hd_b_ch2.appg.tab18_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−2.04 (−4.76, 0.65)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_5 hd_b_ch2.appg.tab18_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab18_1_1_1_6 hd_b_ch2.appg.tab18_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.00 (−1,18, 3.18)</td></tr><tr><th headers="hd_h_ch2.appg.tab18_1_1_1_1" id="hd_b_ch2.appg.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychosocial intervention</th><td headers="hd_h_ch2.appg.tab18_1_1_1_2 hd_b_ch2.appg.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.70 (−0.12, 5.53)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_3 hd_b_ch2.appg.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.80 (−0.38, 3.98)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_4 hd_b_ch2.appg.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.05 (−3.83, 1.75)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_5 hd_b_ch2.appg.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.00 (−1.19, 3.18)</td><td headers="hd_h_ch2.appg.tab18_1_1_1_6 hd_b_ch2.appg.tab18_1_1_5_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig52"><div id="ch2.appg.fig52" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20109.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20quality%20of%20life%2C%20%022646%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy).&p=BOOKS&id=557360_ch2appgf51.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf51.jpg" alt="Figure 109. Diagram of the network of studies underlying the NMA for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 109</span><span class="title">Diagram of the network of studies underlying the NMA for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig53"><div id="ch2.appg.fig53" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20110.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20on%20the%20HoNOSCA%20scale%20for%20quality%20of%20life%2C%20%022646%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%200%20favour%20usual%20care%3B%20values%20lower%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf52.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf52.jpg" alt="Figure 110. Relative effectiveness of all options versus usual care on the HoNOSCA scale for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 110</span><span class="title">Relative effectiveness of all options versus usual care on the HoNOSCA scale for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig54"><div id="ch2.appg.fig54" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20111.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf53.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf53.jpg" alt="Figure 111. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 111</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab19"><div id="ch2.appg.tab19" class="table"><h3><span class="label">Table 30</span><span class="title">Relative effectiveness of all pairwise combinations on the HoNOSCA scale for quality of life, ≤6 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab19/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab19_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.appg.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><th id="hd_h_ch2.appg.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab19_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychosocial intervention</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab19_1_1_1_1" id="hd_b_ch2.appg.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Usual care</th><td headers="hd_h_ch2.appg.tab19_1_1_1_2 hd_b_ch2.appg.tab19_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab19_1_1_1_3 hd_b_ch2.appg.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.88 (−3.63, −0.13)</td><td headers="hd_h_ch2.appg.tab19_1_1_1_4 hd_b_ch2.appg.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab19_1_1_1_5 hd_b_ch2.appg.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab19_1_1_1_1" id="hd_b_ch2.appg.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CBT</th><td headers="hd_h_ch2.appg.tab19_1_1_1_2 hd_b_ch2.appg.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.90 (−3.64, −0.17)</td><td headers="hd_h_ch2.appg.tab19_1_1_1_3 hd_b_ch2.appg.tab19_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab19_1_1_1_4 hd_b_ch2.appg.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.30 (−1.63, 2.23)</td><td headers="hd_h_ch2.appg.tab19_1_1_1_5 hd_b_ch2.appg.tab19_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.50 (−1.47, 2.47)</td></tr><tr><th headers="hd_h_ch2.appg.tab19_1_1_1_1" id="hd_b_ch2.appg.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab19_1_1_1_2 hd_b_ch2.appg.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.61 (−4.19, 1.01)</td><td headers="hd_h_ch2.appg.tab19_1_1_1_3 hd_b_ch2.appg.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.29 (−1.64, 2.23)</td><td headers="hd_h_ch2.appg.tab19_1_1_1_4 hd_b_ch2.appg.tab19_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab19_1_1_1_5 hd_b_ch2.appg.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.20 (−1.68, 2.08)</td></tr><tr><th headers="hd_h_ch2.appg.tab19_1_1_1_1" id="hd_b_ch2.appg.tab19_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.appg.tab19_1_1_1_2 hd_b_ch2.appg.tab19_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−1.41 (−4.03, 1.22)</td><td headers="hd_h_ch2.appg.tab19_1_1_1_3 hd_b_ch2.appg.tab19_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.49 (−1.47, 2.47)</td><td headers="hd_h_ch2.appg.tab19_1_1_1_4 hd_b_ch2.appg.tab19_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.20 (−1.68, 2.08)</td><td headers="hd_h_ch2.appg.tab19_1_1_1_5 hd_b_ch2.appg.tab19_1_1_4_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig55"><div id="ch2.appg.fig55" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20112.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20quality%20of%20life%2C%20%3E6%20to%20%0226418%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy).&p=BOOKS&id=557360_ch2appgf54.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf54.jpg" alt="Figure 112. Diagram of the network of studies underlying the NMA for quality of life, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 112</span><span class="title">Diagram of the network of studies underlying the NMA for quality of life, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig56"><div id="ch2.appg.fig56" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20113.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20on%20the%20HoNOSCA%20scale%20for%20quality%20of%20life%2C%20%3E6%20to%20%0226418%20months%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Mean%20differences%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%200%20favour%20usual%20care%3B%20values%20lower%20than%200%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf55.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf55.jpg" alt="Figure 113. Relative effectiveness of all options versus usual care on the HoNOSCA scale for quality of life, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 113</span><span class="title">Relative effectiveness of all options versus usual care on the HoNOSCA scale for quality of life, >6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Mean differences with 95% credible intervals and line of no effect in red; values higher than 0 favour usual care; values lower than 0 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig57"><div id="ch2.appg.fig57" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20114.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf56.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf56.jpg" alt="Figure 114. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 114</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab20"><div id="ch2.appg.tab20" class="table"><h3><span class="label">Table 31</span><span class="title">Relative effectiveness of all pairwise combinations on the HoNOSCA scale for quality of life, <6 to ≤18 months, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: mean difference (MD) with 95% confidence intervals from direct pair-wise meta-analysis. MDs less than 0 favour the column defining treatment, MDs greater than 0 favour the row defining treatment. Lower diagonal: posterior median MD with 95% credible intervals from NMA results, MDs less than 0 favour the row defining treatment. MDs greater than 0 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab20/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab20_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><th id="hd_h_ch2.appg.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><th id="hd_h_ch2.appg.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab20_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychosocial intervention</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab20_1_1_1_1" id="hd_b_ch2.appg.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Usual care</th><td headers="hd_h_ch2.appg.tab20_1_1_1_2 hd_b_ch2.appg.tab20_1_1_1_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab20_1_1_1_3 hd_b_ch2.appg.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.06 (−1.81, 1.68)</td><td headers="hd_h_ch2.appg.tab20_1_1_1_4 hd_b_ch2.appg.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab20_1_1_1_5 hd_b_ch2.appg.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab20_1_1_1_1" id="hd_b_ch2.appg.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CBT</th><td headers="hd_h_ch2.appg.tab20_1_1_1_2 hd_b_ch2.appg.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.05 (−1.79, 1.68)</td><td headers="hd_h_ch2.appg.tab20_1_1_1_3 hd_b_ch2.appg.tab20_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab20_1_1_1_4 hd_b_ch2.appg.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.10 (−0.75, 2.95)</td><td headers="hd_h_ch2.appg.tab20_1_1_1_5 hd_b_ch2.appg.tab20_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.40 (−1.27, 2.07)</td></tr><tr><th headers="hd_h_ch2.appg.tab20_1_1_1_1" id="hd_b_ch2.appg.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab20_1_1_1_2 hd_b_ch2.appg.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.05 (−1.48, 3.59)</td><td headers="hd_h_ch2.appg.tab20_1_1_1_3 hd_b_ch2.appg.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.10 (−0.75, 2.95)</td><td headers="hd_h_ch2.appg.tab20_1_1_1_4 hd_b_ch2.appg.tab20_1_1_3_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab20_1_1_1_5 hd_b_ch2.appg.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab20_1_1_1_1" id="hd_b_ch2.appg.tab20_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.appg.tab20_1_1_1_2 hd_b_ch2.appg.tab20_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.35 (−2.07, 2.75)</td><td headers="hd_h_ch2.appg.tab20_1_1_1_3 hd_b_ch2.appg.tab20_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.39 (−1.27, 2.07)</td><td headers="hd_h_ch2.appg.tab20_1_1_1_4 hd_b_ch2.appg.tab20_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">−0.70 (−2.58, 1.18)</td><td headers="hd_h_ch2.appg.tab20_1_1_1_5 hd_b_ch2.appg.tab20_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig58"><div id="ch2.appg.fig58" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20115.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20suicide%20ideation%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20NDST%3A%20non-directive%20supportive%20therapy).&p=BOOKS&id=557360_ch2appgf57.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf57.jpg" alt="Figure 115. Diagram of the network of studies underlying the NMA for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; NDST: non-directive supportive therapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 115</span><span class="title">Diagram of the network of studies underlying the NMA for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; NDST: non-directive supportive therapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig59"><div id="ch2.appg.fig59" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20116.%20Relative%20effectiveness%20of%20all%20options%20versus%20usual%20care%20for%20suicide%20ideation%2C%20post-treatment%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Relative%20risk%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%201%20favour%20usual%20care%3B%20values%20lower%20than%201%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf58.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf58.jpg" alt="Figure 116. Relative effectiveness of all options versus usual care for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values higher than 1 favour usual care; values lower than 1 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 116</span><span class="title">Relative effectiveness of all options versus usual care for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Relative risk with 95% credible intervals and line of no effect in red; values higher than 1 favour usual care; values lower than 1 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig60"><div id="ch2.appg.fig60" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20117.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf59.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf59.jpg" alt="Figure 117. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 117</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab21"><div id="ch2.appg.tab21" class="table"><h3><span class="label">Table 32</span><span class="title">Relative effectiveness of all pairwise combinations for suicide ideation, post-treatment, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs less than 1 favour the column defining treatment, RRs greater than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR less than 1 favour the row defining treatment. RRs greater than 1 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab21/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab21_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Pill placebo</th><th id="hd_h_ch2.appg.tab21_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><th id="hd_h_ch2.appg.tab21_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab21_1_1_1_1" id="hd_b_ch2.appg.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Usual care</th><td headers="hd_h_ch2.appg.tab21_1_1_1_2 hd_b_ch2.appg.tab21_1_1_1_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab21_1_1_1_3 hd_b_ch2.appg.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.20 (0.04, 0.89)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_4 hd_b_ch2.appg.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab21_1_1_1_5 hd_b_ch2.appg.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab21_1_1_1_6 hd_b_ch2.appg.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab21_1_1_1_1" id="hd_b_ch2.appg.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab21_1_1_1_2 hd_b_ch2.appg.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.17 (0.02, 0.69)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_3 hd_b_ch2.appg.tab21_1_1_2_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab21_1_1_1_4 hd_b_ch2.appg.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.74 (0.17, 3.23)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_5 hd_b_ch2.appg.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.75 (0.13, 4.17)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_6 hd_b_ch2.appg.tab21_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.75 (0.46, 6.67)</td></tr><tr><th headers="hd_h_ch2.appg.tab21_1_1_1_1" id="hd_b_ch2.appg.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Pill placebo</th><td headers="hd_h_ch2.appg.tab21_1_1_1_2 hd_b_ch2.appg.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.12 (0.01, 0.98)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_3 hd_b_ch2.appg.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.72 (0.13, 3.35)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_4 hd_b_ch2.appg.tab21_1_1_3_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab21_1_1_1_5 hd_b_ch2.appg.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab21_1_1_1_6 hd_b_ch2.appg.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab21_1_1_1_1" id="hd_b_ch2.appg.tab21_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><td headers="hd_h_ch2.appg.tab21_1_1_1_2 hd_b_ch2.appg.tab21_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.11 (0.01, 1.21)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_3 hd_b_ch2.appg.tab21_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.69 (0.08, 4.52)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_4 hd_b_ch2.appg.tab21_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.95 (0.07, 12.05)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_5 hd_b_ch2.appg.tab21_1_1_4_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab21_1_1_1_6 hd_b_ch2.appg.tab21_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.33 (0.49, 11.11)</td></tr><tr><th headers="hd_h_ch2.appg.tab21_1_1_1_1" id="hd_b_ch2.appg.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><td headers="hd_h_ch2.appg.tab21_1_1_1_2 hd_b_ch2.appg.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.33 (0.03, 2.47)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_3 hd_b_ch2.appg.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.95 (0.44, 9.30)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_4 hd_b_ch2.appg.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.73 (0.32, 27.28)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_5 hd_b_ch2.appg.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.79 (0.55, 22.73)</td><td headers="hd_h_ch2.appg.tab21_1_1_1_6 hd_b_ch2.appg.tab21_1_1_5_1" rowspan="1" colspan="1" style="background-color: #cccccc;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig61"><div id="ch2.appg.fig61" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20118.%20Diagram%20of%20the%20network%20of%20studies%20underlying%20the%20NMA%20for%20discontinuation%2C%20endpoint%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20The%20thickness%20of%20the%20line%20represents%20the%20number%20of%20studies.%20(CBT%3A%20cognitive%20behavioural%20therapy%3B%20WL%2FNTX%3A%20waiting%20list%2Fno%20treatment%3B%20NDST%3A%20non-directive%20supportive%20therapy%3B%20IPT%3A%20interpersonal%20psychotherapy).&p=BOOKS&id=557360_ch2appgf60.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf60.jpg" alt="Figure 118. Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy; IPT: interpersonal psychotherapy)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 118</span><span class="title">Diagram of the network of studies underlying the NMA for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds. The thickness of the line represents the number of studies. (CBT: cognitive behavioural therapy; WL/NTX: waiting list/no treatment; NDST: non-directive supportive therapy; IPT: interpersonal psychotherapy)</span></h3></div></article><article data-type="fig" id="figobch2appgfig62"><div id="ch2.appg.fig62" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20119.%20Relative%20effectiveness%20of%20all%20options%20versus%20waiting%20list%2Fno%20treatment%20for%20discontinuation%2C%20endpoint%2C%20in%20moderate%20to%20severe%20depression%2C%2012%20to%2018%20year%20olds.%20(Relative%20risks%20with%2095%25%20credible%20intervals%20and%20line%20of%20no%20effect%20in%20red%3B%20values%20higher%20than%201%20favour%20waiting%20list%2Fno%20treatment%3B%20values%20lower%20than%201%20favour%20the%20other%20treatments.).&p=BOOKS&id=557360_ch2appgf61.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf61.jpg" alt="Figure 119. Relative effectiveness of all options versus waiting list/no treatment for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour waiting list/no treatment; values lower than 1 favour the other treatments.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 119</span><span class="title">Relative effectiveness of all options versus waiting list/no treatment for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds. (Relative risks with 95% credible intervals and line of no effect in red; values higher than 1 favour waiting list/no treatment; values lower than 1 favour the other treatments.)</span></h3></div></article><article data-type="fig" id="figobch2appgfig63"><div id="ch2.appg.fig63" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20120.%20Probability%20of%20the%20treatment%20assuming%20each%20treatment%20rank%20(see%20treatment%20codes%20above.%20Rank%201%20is%20best.).&p=BOOKS&id=557360_ch2appgf62.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf62.jpg" alt="Figure 120. Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 120</span><span class="title">Probability of the treatment assuming each treatment rank (see treatment codes above. Rank 1 is best.)</span></h3></div></article><article data-type="table-wrap" id="figobch2appgtab22"><div id="ch2.appg.tab22" class="table"><h3><span class="label">Table 33</span><span class="title">Relative effectiveness of all pairwise combinations for discontinuation, endpoint, in moderate to severe depression, 12 to 18 year olds. (Upper diagonal: risk ratios (RR) with 95% confidence intervals from the pair-wise meta-analysis. RRs less than 1 favour the column defining treatment, RRs greater than 1 favour the row defining treatment. Lower diagonal: posterior median RRs with 95% credible intervals from NMA results, RR less than 1 favour the row defining treatment. RRs greater than 1 favour the column defining treatment.)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab22/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab22_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><th id="hd_h_ch2.appg.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><th id="hd_h_ch2.appg.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IPT-A</th><th id="hd_h_ch2.appg.tab22_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Pill placebo</th><th id="hd_h_ch2.appg.tab22_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><th id="hd_h_ch2.appg.tab22_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><th id="hd_h_ch2.appg.tab22_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><th id="hd_h_ch2.appg.tab22_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab22_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">psychosocial intervention</th><th id="hd_h_ch2.appg.tab22_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</th><th id="hd_h_ch2.appg.tab22_1_1_1_12" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><th id="hd_h_ch2.appg.tab22_1_1_1_13" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">group CBT + parent sessions</th><th id="hd_h_ch2.appg.tab22_1_1_1_14" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Online guided self-help</th><th id="hd_h_ch2.appg.tab22_1_1_1_15" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Monitoring</th><th id="hd_h_ch2.appg.tab22_1_1_1_16" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><th id="hd_h_ch2.appg.tab22_1_1_1_17" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Behavioural activation</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Waiting list/no treatment</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="background-color: #b7b7b7;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.74 (0.22, 2.41)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.80 (0.25, 2.61)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.65 (0.32, 1.32)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.76 (0.38, 1.52)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.33 (0.59, 31.8)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.61 (0.15, 1.82)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.09 (0.31, 3.85)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.95 (0.57, 1.59)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.32 (0.86, 2.00)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.70 (0.13, 4.00)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.33 (0.35, 5.26)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.47 (0.74, 2.94)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.92 (1.01, 3.70)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.45 (0.26, 7.69)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IPT-A</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.94 (0.28, 2.39)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.51 (0.58, 4.50)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="background-color: #b7b7b7;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.58 (0.12, 2.94)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.35 (1.41, 12.5)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.14 (0.02, 1.00)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Pill placebo</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.58 (0.12, 1.90)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.95 (0.53, 1.61)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.63 (0.18, 1.84)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Usual care</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.88 (0.22, 2.45)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.42 (0.85, 2.51)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.94 (0.33, 2.44)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.50 (0.73, 3.41)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="background-color: #b7b7b7;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.69 (0.22, 2.22)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.21 (0.05, 0.88)</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family therapy</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.54 (0.09, 2.15)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.90 (0.27, 2.43)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.59 (0.12, 2.14)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.95 (0.26, 3.00)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.63 (0.19, 1.61)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.49 (0.27, 8.33)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.86 (0.12, 3.11)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.38 (0.35, 4.24)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.92 (0.16, 3.58)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.45 (0.34, 5.21)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.98 (0.23, 3.03)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.52 (0.39, 6.13)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="background-color: #b7b7b7;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.88 (0.19, 2.62)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.41 (0.75, 2.72)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.94 (0.27, 2.82)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.50 (0.66, 3.61)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.00 (0.43, 2.22)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.58 (0.49, 6.25)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.02 (0.29, 4.64)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.30 (0.74, 2.33)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychosocial intervention</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.13 (0.27, 3.03)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.78 (1.03, 3.38)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.18 (0.38, 3.46)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.89 (0.90, 4.55)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.25 (0.59, 2.76)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.99 (0.66, 7.89)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.28 (0.39, 5.85)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.25 (0.77, 2.26)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="background-color: #b7b7b7;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Relaxation</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.90 (0.09, 3.79)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.43 (0.25, 5.99)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.96 (0.12, 4.63)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.51 (0.25, 7.18)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.02 (0.16, 4.39)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.60 (0.22, 10.36)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.04 (0.13, 7.44)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.02 (0.16, 4.71)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.81 (0.13, 3.46)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.63 (0.27, 1.28)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.04 (0.26, 4.92)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.68 (0.19, 2.73)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.10 (0.25, 5.91)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.72 (0.19, 3.39)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.17 (0.23, 8.34)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.74 (0.15, 5.88)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.72 (0.18, 3.80)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.57 (0.15, 2.75)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.71 (0.13, 7.50)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="background-color: #b7b7b7;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.18 (0.56, 2.44)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + parent sessions</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.75 (0.34, 1.48)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.23 (0.32, 5.79)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.81 (0.23, 3.23)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.30 (0.31, 6.95)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.86 (0.23, 3.97)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.38 (0.28, 9.87)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.88 (0.19, 6.94)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.85 (0.22, 4.50)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.67 (0.18, 3.24)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.84 (0.16, 8.91)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.19 (0.54, 2.62)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_12_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Online guided self-help</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.93 (0.98, 7.02)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.74 (1.06, 25.92)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.09 (0.78, 14.39)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.03 (1.06, 30.76)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.28 (0.79, 17.61)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.34 (0.97, 42.76)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.36 (0.67, 30.17)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.27 (0.75, 19.65)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.56 (0.63, 14.24)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.19 (0.58, 38.55)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.58 (1.28, 16.22)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.86 (1.10, 13.38)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="background-color: #b7b7b7;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Monitoring</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.99 (1.13, 6.65)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.81 (1.62, 20.03)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.15 (1.45, 9.04)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.10 (1.56, 24.16)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.32 (1.25, 13.53)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.43 (1.38, 34.61)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.41 (0.97, 24.75)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.31 (1.15, 15.62)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2.59 (0.99, 11.32)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.25 (0.81, 32.26)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4.69 (1.46, 15.76)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3.94 (1.26, 12.84)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.00 (0.31, 3.62)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_14_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group IPT</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.07 (0.00, 0.79)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.12 (0.00, 1.19)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.08 (0.00, 0.58)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.13 (0.00, 1.35)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (0.00, 0.82)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.14 (0.00, 1.79)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (0.00, 1.25)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (0.00, 0.90)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.07 (0.00, 0.70)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.09 (0.00, 1.51)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.12 (0.00, 1.44)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.10 (0.00, 1.20)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.03 (0.00, 0.34)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.02 (0.00, 0.25)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="background-color: #b7b7b7;text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td></tr><tr><th headers="hd_h_ch2.appg.tab22_1_1_1_1" id="hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Behavioural activation</th><td headers="hd_h_ch2.appg.tab22_1_1_1_2 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.13 (0.01, 1.01)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_3 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.23 (0.03, 1.10)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_4 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.15 (0.01, 0.91)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_5 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.24 (0.03, 1.29)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_6 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.16 (0.02, 0.70)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_7 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.26 (0.03, 1.66)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_8 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.17 (0.01, 1.26)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_9 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.16 (0.02, 0.88)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_10 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.13 (0.01, 0.68)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_11 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.16 (0.01, 1.62)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_12 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.21 (0.02, 1.88)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_13 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.18 (0.01, 1.57)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_14 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.05 (0.00, 0.45)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_15 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.05 (0.00, 0.34)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_16 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1.84 (0.08, 82.50)</td><td headers="hd_h_ch2.appg.tab22_1_1_1_17 hd_b_ch2.appg.tab22_1_1_16_1" rowspan="1" colspan="1" style="background-color: #d0cece;text-align:left;vertical-align:top;"></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appgtab23"><div id="ch2.appg.tab23" class="table"><h3><span class="label">Table 34</span><span class="title">Age 12–18, Mild, Depressive Symptoms Post Treatment (pairwise probability more effective)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab23/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab23_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">group CBT</th><th id="hd_h_ch2.appg.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">relaxation</th><th id="hd_h_ch2.appg.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">dance therapy</th><th id="hd_h_ch2.appg.tab23_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">guided self-help</th><th id="hd_h_ch2.appg.tab23_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">group NDST</th><th id="hd_h_ch2.appg.tab23_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">attention control</th><th id="hd_h_ch2.appg.tab23_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">usual care</th><th id="hd_h_ch2.appg.tab23_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">group mindfulness</th><th id="hd_h_ch2.appg.tab23_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><th id="hd_h_ch2.appg.tab23_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><th id="hd_h_ch2.appg.tab23_1_1_1_12" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">computer CBT</th><th id="hd_h_ch2.appg.tab23_1_1_1_13" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">groupCBT + computer CBT</th><th id="hd_h_ch2.appg.tab23_1_1_1_14" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">family therapy</th><th id="hd_h_ch2.appg.tab23_1_1_1_15" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">group IPT</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">waiting list</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#00b050;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>1.00</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#0bb44c;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>0.98</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#12b64a;text-align:center;vertical-align:middle;">0.97</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#01b14f;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>1.00</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#18b848;text-align:center;vertical-align:middle;">0.95</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#02b14f;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>1.00</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#02b14f;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>1.00</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#02b14f;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>1.00</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#17b848;text-align:center;vertical-align:middle;">0.96</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#92dd22;text-align:center;vertical-align:middle;">0.72</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#00b050;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>1.00</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#07b34d;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>0.99</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#06b24e;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>0.99</b>
|
|
</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_1_1" rowspan="1" colspan="1" style="background-color:#04b24e;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>0.99</b>
|
|
</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">group CBT</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#bfeb14;text-align:center;vertical-align:middle;">0.63</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#e0f60a;text-align:center;vertical-align:middle;">0.56</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#f5fc03;text-align:center;vertical-align:middle;">0.52</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff7c00;text-align:center;vertical-align:middle;">0.24</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff7d00;text-align:center;vertical-align:middle;">0.25</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff9e00;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#2cbe42;text-align:center;vertical-align:middle;">0.91</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#f9fe02;text-align:center;vertical-align:middle;">0.51</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff7000;text-align:center;vertical-align:middle;">0.22</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#34c03f;text-align:center;vertical-align:middle;">0.90</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#d2f10e;text-align:center;vertical-align:middle;">0.59</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#67d02f;text-align:center;vertical-align:middle;">0.80</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_2_1" rowspan="1" colspan="1" style="background-color:#71d32c;text-align:center;vertical-align:middle;">0.78</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">relaxation</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffbe00;text-align:center;vertical-align:middle;">0.37</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffe800;text-align:center;vertical-align:middle;">0.46</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffcc00;text-align:center;vertical-align:middle;">0.40</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ff7e00;text-align:center;vertical-align:middle;">0.25</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ff9100;text-align:center;vertical-align:middle;">0.29</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ff9e00;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#6ed22d;text-align:center;vertical-align:middle;">0.79</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffd600;text-align:center;vertical-align:middle;">0.42</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ff6b00;text-align:center;vertical-align:middle;">0.21</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#cff00f;text-align:center;vertical-align:middle;">0.60</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffe700;text-align:center;vertical-align:middle;">0.45</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#b3e818;text-align:center;vertical-align:middle;">0.65</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_3_1" rowspan="1" colspan="1" style="background-color:#c3ed13;text-align:center;vertical-align:middle;">0.62</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">dance therapy</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffdf00;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#e9f907;text-align:center;vertical-align:middle;">0.54</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffea00;text-align:center;vertical-align:middle;">0.46</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff9700;text-align:center;vertical-align:middle;">0.30</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffb100;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffbd00;text-align:center;vertical-align:middle;">0.37</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#69d12f;text-align:center;vertical-align:middle;">0.79</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffec00;text-align:center;vertical-align:middle;">0.46</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff7c00;text-align:center;vertical-align:middle;">0.24</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#bbea15;text-align:center;vertical-align:middle;">0.63</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#fffe00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#a3e31d;text-align:center;vertical-align:middle;">0.68</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_4_1" rowspan="1" colspan="1" style="background-color:#b2e718;text-align:center;vertical-align:middle;">0.65</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">guided self-help</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#fff400;text-align:center;vertical-align:middle;">0.48</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#cdf00f;text-align:center;vertical-align:middle;">0.60</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ebf906;text-align:center;vertical-align:middle;">0.54</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ff7700;text-align:center;vertical-align:middle;">0.23</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ff9d00;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ffba00;text-align:center;vertical-align:middle;">0.37</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#42c53b;text-align:center;vertical-align:middle;">0.87</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ffff00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ff7600;text-align:center;vertical-align:middle;">0.23</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#70d32d;text-align:center;vertical-align:middle;">0.78</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#e2f609;text-align:center;vertical-align:middle;">0.56</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#7ad629;text-align:center;vertical-align:middle;">0.76</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_5_1" rowspan="1" colspan="1" style="background-color:#7cd729;text-align:center;vertical-align:middle;">0.76</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">group NDST</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#7dd728;text-align:center;vertical-align:middle;">0.76</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#7fd828;text-align:center;vertical-align:middle;">0.75</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#98e020;text-align:center;vertical-align:middle;">0.70</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#78d52a;text-align:center;vertical-align:middle;">0.77</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#c3ed13;text-align:center;vertical-align:middle;">0.62</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#b2e718;text-align:center;vertical-align:middle;">0.65</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#24bc44;text-align:center;vertical-align:middle;">0.93</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#a9e51b;text-align:center;vertical-align:middle;">0.67</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ffbb00;text-align:center;vertical-align:middle;">0.37</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#34c03f;text-align:center;vertical-align:middle;">0.90</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#84d926;text-align:center;vertical-align:middle;">0.74</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#4ac738;text-align:center;vertical-align:middle;">0.86</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_6_1" rowspan="1" colspan="1" style="background-color:#09b34d;color:#ffffff;text-align:center;vertical-align:middle;">
|
|
<b>0.98</b>
|
|
</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">attention control</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#7fd828;text-align:center;vertical-align:middle;">0.75</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#92de22;text-align:center;vertical-align:middle;">0.71</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#b2e718;text-align:center;vertical-align:middle;">0.65</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#9fe11e;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffc100;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#def50a;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#22bb45;text-align:center;vertical-align:middle;">0.93</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#c2ec13;text-align:center;vertical-align:middle;">0.62</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ff9200;text-align:center;vertical-align:middle;">0.29</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#0db44b;text-align:center;vertical-align:middle;">0.97</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#8cdc24;text-align:center;vertical-align:middle;">0.73</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#49c739;text-align:center;vertical-align:middle;">0.86</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_7_1" rowspan="1" colspan="1" style="background-color:#51c936;text-align:center;vertical-align:middle;">0.84</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">usual care</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#9fe21e;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#9fe21e;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#beeb14;text-align:center;vertical-align:middle;">0.63</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#bbea15;text-align:center;vertical-align:middle;">0.63</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ffb100;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ffdd00;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#26bc44;text-align:center;vertical-align:middle;">0.93</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#c9ef11;text-align:center;vertical-align:middle;">0.61</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ff8400;text-align:center;vertical-align:middle;">0.26</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#24bb44;text-align:center;vertical-align:middle;">0.93</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#a8e41b;text-align:center;vertical-align:middle;">0.67</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#45c63a;text-align:center;vertical-align:middle;">0.87</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_8_1" rowspan="1" colspan="1" style="background-color:#5dcd33;text-align:center;vertical-align:middle;">0.82</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">group mindfulness</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff2b00;text-align:center;vertical-align:middle;">0.09</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff6d00;text-align:center;vertical-align:middle;">0.21</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff6800;text-align:center;vertical-align:middle;">0.21</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff4100;text-align:center;vertical-align:middle;">0.13</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff2300;text-align:center;vertical-align:middle;">0.07</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff2100;text-align:center;vertical-align:middle;">0.07</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff2500;text-align:center;vertical-align:middle;">0.07</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff5700;text-align:center;vertical-align:middle;">0.17</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff2800;text-align:center;vertical-align:middle;">0.08</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff6e00;text-align:center;vertical-align:middle;">0.22</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff5600;text-align:center;vertical-align:middle;">0.17</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ffb800;text-align:center;vertical-align:middle;">0.36</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff9900;text-align:center;vertical-align:middle;">0.30</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">CBT</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#fff800;text-align:center;vertical-align:middle;">0.49</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#d7f30c;text-align:center;vertical-align:middle;">0.58</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#edfa05;text-align:center;vertical-align:middle;">0.54</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#fffe00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#ffa800;text-align:center;vertical-align:middle;">0.33</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#ffc100;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#ffc800;text-align:center;vertical-align:middle;">0.39</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#58cc34;text-align:center;vertical-align:middle;">0.83</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#ff3b00;text-align:center;vertical-align:middle;">0.12</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#9be01f;text-align:center;vertical-align:middle;">0.70</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#eaf906;text-align:center;vertical-align:middle;">0.54</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#86da25;text-align:center;vertical-align:middle;">0.74</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_10_1" rowspan="1" colspan="1" style="background-color:#9fe21e;text-align:center;vertical-align:middle;">0.69</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">NDST</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#71d32c;text-align:center;vertical-align:middle;">0.78</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#6cd22e;text-align:center;vertical-align:middle;">0.79</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#7dd728;text-align:center;vertical-align:middle;">0.76</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#77d52a;text-align:center;vertical-align:middle;">0.77</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#bceb15;text-align:center;vertical-align:middle;">0.63</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#94de21;text-align:center;vertical-align:middle;">0.71</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#85da26;text-align:center;vertical-align:middle;">0.74</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#29bd43;text-align:center;vertical-align:middle;">0.92</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#3cc33d;text-align:center;vertical-align:middle;">0.88</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#43c53b;text-align:center;vertical-align:middle;">0.87</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#71d32c;text-align:center;vertical-align:middle;">0.78</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#3dc33c;text-align:center;vertical-align:middle;">0.88</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_11_1" rowspan="1" colspan="1" style="background-color:#4ac738;text-align:center;vertical-align:middle;">0.86</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">computer CBT</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ff3300;text-align:center;vertical-align:middle;">0.10</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ffce00;text-align:center;vertical-align:middle;">0.40</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ffb900;text-align:center;vertical-align:middle;">0.36</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ff6f00;text-align:center;vertical-align:middle;">0.22</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ff3300;text-align:center;vertical-align:middle;">0.10</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ff0c00;text-align:center;vertical-align:middle;">0.03</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ff2300;text-align:center;vertical-align:middle;">0.07</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#70d32d;text-align:center;vertical-align:middle;">0.78</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ff9a00;text-align:center;vertical-align:middle;">0.30</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ff4200;text-align:center;vertical-align:middle;">0.13</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ff9b00;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#c5ed12;text-align:center;vertical-align:middle;">0.62</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_12_1" rowspan="1" colspan="1" style="background-color:#e2f609;text-align:center;vertical-align:middle;">0.56</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">groupCBT + computer CBT</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffd000;text-align:center;vertical-align:middle;">0.41</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#e8f807;text-align:center;vertical-align:middle;">0.55</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffff00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffe100;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ff8300;text-align:center;vertical-align:middle;">0.26</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ff8b00;text-align:center;vertical-align:middle;">0.27</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffa700;text-align:center;vertical-align:middle;">0.33</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#57cb34;text-align:center;vertical-align:middle;">0.83</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffe900;text-align:center;vertical-align:middle;">0.46</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ff7000;text-align:center;vertical-align:middle;">0.22</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#9ce11f;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#93de22;text-align:center;vertical-align:middle;">0.71</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_13_1" rowspan="1" colspan="1" style="background-color:#a8e41b;text-align:center;vertical-align:middle;">0.67</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">family therapy</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff6600;text-align:center;vertical-align:middle;">0.20</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ffb200;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ffa100;text-align:center;vertical-align:middle;">0.32</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff7900;text-align:center;vertical-align:middle;">0.24</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff4900;text-align:center;vertical-align:middle;">0.14</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff4800;text-align:center;vertical-align:middle;">0.14</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff4400;text-align:center;vertical-align:middle;">0.13</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#b9ea15;text-align:center;vertical-align:middle;">0.64</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff8500;text-align:center;vertical-align:middle;">0.26</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff3c00;text-align:center;vertical-align:middle;">0.12</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ffc300;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff9200;text-align:center;vertical-align:middle;">0.29</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ffe200;text-align:center;vertical-align:middle;">0.44</td></tr><tr><th headers="hd_h_ch2.appg.tab23_1_1_1_1" id="hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">group IPT</th><td headers="hd_h_ch2.appg.tab23_1_1_1_2 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ff7000;text-align:center;vertical-align:middle;">0.22</td><td headers="hd_h_ch2.appg.tab23_1_1_1_3 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffc200;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab23_1_1_1_4 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffb100;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab23_1_1_1_5 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ff7b00;text-align:center;vertical-align:middle;">0.24</td><td headers="hd_h_ch2.appg.tab23_1_1_1_6 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ff0800;text-align:center;vertical-align:middle;">0.02</td><td headers="hd_h_ch2.appg.tab23_1_1_1_7 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ff5000;text-align:center;vertical-align:middle;">0.16</td><td headers="hd_h_ch2.appg.tab23_1_1_1_8 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ff5b00;text-align:center;vertical-align:middle;">0.18</td><td headers="hd_h_ch2.appg.tab23_1_1_1_9 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#9ae01f;text-align:center;vertical-align:middle;">0.70</td><td headers="hd_h_ch2.appg.tab23_1_1_1_10 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ff9e00;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab23_1_1_1_11 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ff4900;text-align:center;vertical-align:middle;">0.14</td><td headers="hd_h_ch2.appg.tab23_1_1_1_12 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffe000;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab23_1_1_1_13 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffa700;text-align:center;vertical-align:middle;">0.33</td><td headers="hd_h_ch2.appg.tab23_1_1_1_14 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#e4f708;text-align:center;vertical-align:middle;">0.55</td><td headers="hd_h_ch2.appg.tab23_1_1_1_15 hd_b_ch2.appg.tab23_1_1_15_1" rowspan="1" colspan="1" style="background-color:#cccccc;text-align:center;vertical-align:middle;"></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appgtab24"><div id="ch2.appg.tab24" class="table"><h3><span class="label">Table 35</span><span class="title">Age 12–18, Severe. Depressive Symptoms Post Treatment (pairwise probability more effective)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab24/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab24_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th id="hd_h_ch2.appg.tab24_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT</th><th id="hd_h_ch2.appg.tab24_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">individual IPT</th><th id="hd_h_ch2.appg.tab24_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">pill placebo</th><th id="hd_h_ch2.appg.tab24_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">usual care</th><th id="hd_h_ch2.appg.tab24_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">family therapy</th><th id="hd_h_ch2.appg.tab24_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><th id="hd_h_ch2.appg.tab24_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">psychodynamic psychotherapy</th><th id="hd_h_ch2.appg.tab24_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">psychosocial intervention</th><th id="hd_h_ch2.appg.tab24_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">relaxation</th><th id="hd_h_ch2.appg.tab24_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">computer CBT</th><th id="hd_h_ch2.appg.tab24_1_1_1_12" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">attention control</th><th id="hd_h_ch2.appg.tab24_1_1_1_13" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">group CBT</th><th id="hd_h_ch2.appg.tab24_1_1_1_14" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">group CBT + parent sessions</th><th id="hd_h_ch2.appg.tab24_1_1_1_15" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">guided self-help</th><th id="hd_h_ch2.appg.tab24_1_1_1_16" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">monitoring</th><th id="hd_h_ch2.appg.tab24_1_1_1_17" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">group IPT</th><th id="hd_h_ch2.appg.tab24_1_1_1_18" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">behavioural activation</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">waiting list</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#02b14f;color:#ffffff;text-align:center;vertical-align:middle;">
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<b>1.00</b>
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</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#08b34d;color:#ffffff;text-align:center;vertical-align:middle;">
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<b>0.98</b>
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</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#10b54a;text-align:center;vertical-align:middle;">0.97</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#0cb44c;color:#ffffff;text-align:center;vertical-align:middle;">
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<b>0.98</b>
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</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#0db44c;color:#ffffff;text-align:center;vertical-align:middle;">
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<b>0.98</b>
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</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#1cb947;text-align:center;vertical-align:middle;">0.95</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#2bbe42;text-align:center;vertical-align:middle;">0.92</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#47c639;text-align:center;vertical-align:middle;">0.86</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#b8e916;text-align:center;vertical-align:middle;">0.64</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#38c23e;text-align:center;vertical-align:middle;">0.89</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#67d02f;text-align:center;vertical-align:middle;">0.80</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#09b34d;color:#ffffff;text-align:center;vertical-align:middle;">
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<b>0.98</b>
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</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#12b64a;text-align:center;vertical-align:middle;">0.97</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#2abd42;text-align:center;vertical-align:middle;">0.92</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#49c739;text-align:center;vertical-align:middle;">0.86</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#32c040;text-align:center;vertical-align:middle;">0.90</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_1_1" rowspan="1" colspan="1" style="background-color:#18b848;text-align:center;vertical-align:middle;">0.95</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">CBT</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#fff400;text-align:center;vertical-align:middle;">0.48</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#b9ea16;text-align:center;vertical-align:middle;">0.64</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff4800;text-align:center;vertical-align:middle;">0.14</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ffca00;text-align:center;vertical-align:middle;">0.40</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ffe200;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ffab00;text-align:center;vertical-align:middle;">0.34</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff6d00;text-align:center;vertical-align:middle;">0.21</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff2d00;text-align:center;vertical-align:middle;">0.09</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#dcf50b;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff9a00;text-align:center;vertical-align:middle;">0.30</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff8f00;text-align:center;vertical-align:middle;">0.28</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ff8400;text-align:center;vertical-align:middle;">0.26</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ffd000;text-align:center;vertical-align:middle;">0.41</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ffab00;text-align:center;vertical-align:middle;">0.34</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#ffef00;text-align:center;vertical-align:middle;">0.47</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_2_1" rowspan="1" colspan="1" style="background-color:#cef00f;text-align:center;vertical-align:middle;">0.60</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">individual IPT</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#f6fc03;text-align:center;vertical-align:middle;">0.52</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#c1ec13;text-align:center;vertical-align:middle;">0.62</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ff7e00;text-align:center;vertical-align:middle;">0.25</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffde00;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffee00;text-align:center;vertical-align:middle;">0.47</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffc200;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ff8b00;text-align:center;vertical-align:middle;">0.27</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ff4300;text-align:center;vertical-align:middle;">0.13</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#dcf40b;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffa500;text-align:center;vertical-align:middle;">0.33</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffaa00;text-align:center;vertical-align:middle;">0.34</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ff9b00;text-align:center;vertical-align:middle;">0.30</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffd700;text-align:center;vertical-align:middle;">0.42</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#ffa000;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#fff100;text-align:center;vertical-align:middle;">0.47</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_3_1" rowspan="1" colspan="1" style="background-color:#cdf00f;text-align:center;vertical-align:middle;">0.60</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">pill placebo</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffb800;text-align:center;vertical-align:middle;">0.36</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffc000;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff6b00;text-align:center;vertical-align:middle;">0.21</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffa800;text-align:center;vertical-align:middle;">0.33</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffba00;text-align:center;vertical-align:middle;">0.37</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff9500;text-align:center;vertical-align:middle;">0.29</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff6a00;text-align:center;vertical-align:middle;">0.21</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff3700;text-align:center;vertical-align:middle;">0.11</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#fffb00;text-align:center;vertical-align:middle;">0.49</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff8800;text-align:center;vertical-align:middle;">0.27</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff8700;text-align:center;vertical-align:middle;">0.27</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff7d00;text-align:center;vertical-align:middle;">0.25</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffb100;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ff9500;text-align:center;vertical-align:middle;">0.29</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#ffc900;text-align:center;vertical-align:middle;">0.40</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_4_1" rowspan="1" colspan="1" style="background-color:#fffa00;text-align:center;vertical-align:middle;">0.49</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">usual care</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#49c739;text-align:center;vertical-align:middle;">0.86</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#7fd828;text-align:center;vertical-align:middle;">0.75</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#6cd22e;text-align:center;vertical-align:middle;">0.79</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#96df20;text-align:center;vertical-align:middle;">0.71</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#aee619;text-align:center;vertical-align:middle;">0.66</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#e4f708;text-align:center;vertical-align:middle;">0.55</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ffd100;text-align:center;vertical-align:middle;">0.41</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ff6700;text-align:center;vertical-align:middle;">0.20</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#a1e21d;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#ffe100;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#e1f609;text-align:center;vertical-align:middle;">0.56</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#fffa00;text-align:center;vertical-align:middle;">0.49</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#dcf40b;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#fffd00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#c0ec13;text-align:center;vertical-align:middle;">0.62</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_5_1" rowspan="1" colspan="1" style="background-color:#c0ec13;text-align:center;vertical-align:middle;">0.77</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">family therapy</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ccef10;text-align:center;vertical-align:middle;">0.60</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#e0f609;text-align:center;vertical-align:middle;">0.56</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#a9e51b;text-align:center;vertical-align:middle;">0.67</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ff9500;text-align:center;vertical-align:middle;">0.29</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#f5fc03;text-align:center;vertical-align:middle;">0.52</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ffda00;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ff9d00;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ff4c00;text-align:center;vertical-align:middle;">0.15</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#c4ed12;text-align:center;vertical-align:middle;">0.62</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ffa600;text-align:center;vertical-align:middle;">0.33</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ffc800;text-align:center;vertical-align:middle;">0.39</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ffb700;text-align:center;vertical-align:middle;">0.36</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ffee00;text-align:center;vertical-align:middle;">0.47</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#ffca00;text-align:center;vertical-align:middle;">0.40</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#f5fc03;text-align:center;vertical-align:middle;">0.52</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_6_1" rowspan="1" colspan="1" style="background-color:#b5e817;text-align:center;vertical-align:middle;">0.65</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">NDST</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#e4f708;text-align:center;vertical-align:middle;">0.55</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#effa05;text-align:center;vertical-align:middle;">0.53</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#bbea15;text-align:center;vertical-align:middle;">0.63</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffac00;text-align:center;vertical-align:middle;">0.34</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#fff400;text-align:center;vertical-align:middle;">0.48</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffd500;text-align:center;vertical-align:middle;">0.42</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffa000;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ff5500;text-align:center;vertical-align:middle;">0.17</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#d3f20e;text-align:center;vertical-align:middle;">0.59</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffb000;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffca00;text-align:center;vertical-align:middle;">0.40</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffb900;text-align:center;vertical-align:middle;">0.36</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffe700;text-align:center;vertical-align:middle;">0.45</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#ffc900;text-align:center;vertical-align:middle;">0.39</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#fdff00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_7_1" rowspan="1" colspan="1" style="background-color:#c5ed12;text-align:center;vertical-align:middle;">0.61</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">psychodynamic psychotherapy</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ace61a;text-align:center;vertical-align:middle;">0.66</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#c3ed13;text-align:center;vertical-align:middle;">0.62</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#96df20;text-align:center;vertical-align:middle;">0.71</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ffe300;text-align:center;vertical-align:middle;">0.45</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#dbf40b;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#d6f30c;text-align:center;vertical-align:middle;">0.58</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ffaf00;text-align:center;vertical-align:middle;">0.34</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ff6d00;text-align:center;vertical-align:middle;">0.21</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#bbea15;text-align:center;vertical-align:middle;">0.64</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ffd700;text-align:center;vertical-align:middle;">0.42</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#fff700;text-align:center;vertical-align:middle;">0.48</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ffe300;text-align:center;vertical-align:middle;">0.45</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#f4fc03;text-align:center;vertical-align:middle;">0.52</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#ffeb00;text-align:center;vertical-align:middle;">0.46</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#dcf50b;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_8_1" rowspan="1" colspan="1" style="background-color:#a6e41c;text-align:center;vertical-align:middle;">0.68</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">psychosocial intervention</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#6ed22d;text-align:center;vertical-align:middle;">0.79</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#8cdc24;text-align:center;vertical-align:middle;">0.73</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#6bd22e;text-align:center;vertical-align:middle;">0.79</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#d2f20e;text-align:center;vertical-align:middle;">0.59</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#9ee11e;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#a1e21d;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#b0e718;text-align:center;vertical-align:middle;">0.66</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#ff9700;text-align:center;vertical-align:middle;">0.30</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#98df20;text-align:center;vertical-align:middle;">0.70</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#fbfe01;text-align:center;vertical-align:middle;">0.51</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#c7ee11;text-align:center;vertical-align:middle;">0.61</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#dff50a;text-align:center;vertical-align:middle;">0.56</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#c4ed12;text-align:center;vertical-align:middle;">0.62</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#e4f708;text-align:center;vertical-align:middle;">0.55</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#b1e718;text-align:center;vertical-align:middle;">0.65</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_9_1" rowspan="1" colspan="1" style="background-color:#7ed728;text-align:center;vertical-align:middle;">0.75</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">relaxation</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#2ebf41;text-align:center;vertical-align:middle;">0.91</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#44c53a;text-align:center;vertical-align:middle;">0.87</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#38c23e;text-align:center;vertical-align:middle;">0.89</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#68d02f;text-align:center;vertical-align:middle;">0.80</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#4dc837;text-align:center;vertical-align:middle;">0.85</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#56cb35;text-align:center;vertical-align:middle;">0.83</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#6ed22d;text-align:center;vertical-align:middle;">0.79</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#98e020;text-align:center;vertical-align:middle;">0.70</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#60ce31;text-align:center;vertical-align:middle;">0.81</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#a5e41c;text-align:center;vertical-align:middle;">0.68</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#67d02f;text-align:center;vertical-align:middle;">0.80</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#7bd629;text-align:center;vertical-align:middle;">0.76</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#78d52a;text-align:center;vertical-align:middle;">0.77</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#8ddc23;text-align:center;vertical-align:middle;">0.72</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#6bd12e;text-align:center;vertical-align:middle;">0.79</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_10_1" rowspan="1" colspan="1" style="background-color:#46c63a;text-align:center;vertical-align:middle;">0.86</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">computer CBT</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffdb00;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffdb00;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#fcfe01;text-align:center;vertical-align:middle;">0.51</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ff9f00;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffc300;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffd100;text-align:center;vertical-align:middle;">0.41</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffb900;text-align:center;vertical-align:middle;">0.36</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ff9700;text-align:center;vertical-align:middle;">0.30</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ff5f00;text-align:center;vertical-align:middle;">0.19</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ff5000;text-align:center;vertical-align:middle;">0.16</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffb100;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffa700;text-align:center;vertical-align:middle;">0.33</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffc600;text-align:center;vertical-align:middle;">0.39</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffb100;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#ffda00;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_11_1" rowspan="1" colspan="1" style="background-color:#feff00;text-align:center;vertical-align:middle;">0.50</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">attention control</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#9be01f;text-align:center;vertical-align:middle;">0.70</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#a7e41b;text-align:center;vertical-align:middle;">0.67</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#89db25;text-align:center;vertical-align:middle;">0.73</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#e2f609;text-align:center;vertical-align:middle;">0.56</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#a7e41b;text-align:center;vertical-align:middle;">0.67</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#b1e718;text-align:center;vertical-align:middle;">0.65</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#d8f30c;text-align:center;vertical-align:middle;">0.58</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#fffa00;text-align:center;vertical-align:middle;">0.49</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ffa400;text-align:center;vertical-align:middle;">0.32</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#51c936;text-align:center;vertical-align:middle;">0.84</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#d7f30c;text-align:center;vertical-align:middle;">0.58</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#e8f807;text-align:center;vertical-align:middle;">0.55</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#d1f10e;text-align:center;vertical-align:middle;">0.59</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#ebf906;text-align:center;vertical-align:middle;">0.54</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#bfeb14;text-align:center;vertical-align:middle;">0.63</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_12_1" rowspan="1" colspan="1" style="background-color:#91dd22;text-align:center;vertical-align:middle;">0.72</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">group CBT</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#90dd23;text-align:center;vertical-align:middle;">0.72</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#abe51a;text-align:center;vertical-align:middle;">0.66</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#88da25;text-align:center;vertical-align:middle;">0.73</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffe000;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#c9ef10;text-align:center;vertical-align:middle;">0.61</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#cbef10;text-align:center;vertical-align:middle;">0.60</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#f8fd02;text-align:center;vertical-align:middle;">0.52</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffc600;text-align:center;vertical-align:middle;">0.39</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ff6600;text-align:center;vertical-align:middle;">0.20</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#b2e718;text-align:center;vertical-align:middle;">0.65</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffd600;text-align:center;vertical-align:middle;">0.42</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffdb00;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#edfa05;text-align:center;vertical-align:middle;">0.54</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#ffee00;text-align:center;vertical-align:middle;">0.47</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#d3f20d;text-align:center;vertical-align:middle;">0.59</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_13_1" rowspan="1" colspan="1" style="background-color:#96df21;text-align:center;vertical-align:middle;">0.71</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">group CBT + parent sessions</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#86da26;text-align:center;vertical-align:middle;">0.74</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#9ce11f;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#7ed728;text-align:center;vertical-align:middle;">0.75</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#fbfe01;text-align:center;vertical-align:middle;">0.51</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#b8e916;text-align:center;vertical-align:middle;">0.64</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#baea15;text-align:center;vertical-align:middle;">0.64</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#e4f708;text-align:center;vertical-align:middle;">0.55</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ffde00;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ff7900;text-align:center;vertical-align:middle;">0.24</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#a8e41b;text-align:center;vertical-align:middle;">0.67</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#ffe700;text-align:center;vertical-align:middle;">0.45</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#dcf50b;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#daf40b;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#fffe00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#c5ed12;text-align:center;vertical-align:middle;">0.61</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_14_1" rowspan="1" colspan="1" style="background-color:#8ddc23;text-align:center;vertical-align:middle;">0.72</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">guided self-help</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#d1f10e;text-align:center;vertical-align:middle;">0.59</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#d8f30c;text-align:center;vertical-align:middle;">0.58</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#b2e718;text-align:center;vertical-align:middle;">0.65</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffdb00;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#effa05;text-align:center;vertical-align:middle;">0.53</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#e8f807;text-align:center;vertical-align:middle;">0.55</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#fff300;text-align:center;vertical-align:middle;">0.48</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffc300;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ff7700;text-align:center;vertical-align:middle;">0.23</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#c7ee11;text-align:center;vertical-align:middle;">0.61</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffd000;text-align:center;vertical-align:middle;">0.41</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffeb00;text-align:center;vertical-align:middle;">0.46</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffd900;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#ffe200;text-align:center;vertical-align:middle;">0.44</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#eaf906;text-align:center;vertical-align:middle;">0.54</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_15_1" rowspan="1" colspan="1" style="background-color:#baea15;text-align:center;vertical-align:middle;">0.64</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">monitoring</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#ace61a;text-align:center;vertical-align:middle;">0.66</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#a1e21d;text-align:center;vertical-align:middle;">0.69</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#96df21;text-align:center;vertical-align:middle;">0.71</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#feff00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#cbef10;text-align:center;vertical-align:middle;">0.60</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#caef10;text-align:center;vertical-align:middle;">0.60</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#ecf906;text-align:center;vertical-align:middle;">0.54</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#ffe300;text-align:center;vertical-align:middle;">0.45</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#ff8c00;text-align:center;vertical-align:middle;">0.28</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#b2e718;text-align:center;vertical-align:middle;">0.65</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#ffe900;text-align:center;vertical-align:middle;">0.46</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#effa05;text-align:center;vertical-align:middle;">0.53</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#ffff00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#e3f708;text-align:center;vertical-align:middle;">0.56</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#c6ee12;text-align:center;vertical-align:middle;">0.61</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_16_1" rowspan="1" colspan="1" style="background-color:#9fe21e;text-align:center;vertical-align:middle;">0.69</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">group IPT</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#f0fb04;text-align:center;vertical-align:middle;">0.53</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#f2fb04;text-align:center;vertical-align:middle;">0.53</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#cbef10;text-align:center;vertical-align:middle;">0.60</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#ffbf00;text-align:center;vertical-align:middle;">0.38</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#fff400;text-align:center;vertical-align:middle;">0.48</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#fffc00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#ffdb00;text-align:center;vertical-align:middle;">0.43</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#ffb000;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#ff6a00;text-align:center;vertical-align:middle;">0.21</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#dbf40b;text-align:center;vertical-align:middle;">0.57</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#ffbe00;text-align:center;vertical-align:middle;">0.37</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#ffd200;text-align:center;vertical-align:middle;">0.41</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#ffc400;text-align:center;vertical-align:middle;">0.39</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#ffe900;text-align:center;vertical-align:middle;">0.46</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#efb900;text-align:center;vertical-align:middle;">0.39</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_17_1" rowspan="1" colspan="1" style="background-color:#d1f10e;text-align:center;vertical-align:middle;">0.59</td></tr><tr><th headers="hd_h_ch2.appg.tab24_1_1_1_1" id="hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">behavioural activation</th><td headers="hd_h_ch2.appg.tab24_1_1_1_2 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ffcd00;text-align:center;vertical-align:middle;">0.40</td><td headers="hd_h_ch2.appg.tab24_1_1_1_3 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ffcc00;text-align:center;vertical-align:middle;">0.40</td><td headers="hd_h_ch2.appg.tab24_1_1_1_4 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#fbfe01;text-align:center;vertical-align:middle;">0.51</td><td headers="hd_h_ch2.appg.tab24_1_1_1_5 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ff7400;text-align:center;vertical-align:middle;">0.23</td><td headers="hd_h_ch2.appg.tab24_1_1_1_6 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ffb400;text-align:center;vertical-align:middle;">0.35</td><td headers="hd_h_ch2.appg.tab24_1_1_1_7 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ffc400;text-align:center;vertical-align:middle;">0.39</td><td headers="hd_h_ch2.appg.tab24_1_1_1_8 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ffa500;text-align:center;vertical-align:middle;">0.32</td><td headers="hd_h_ch2.appg.tab24_1_1_1_9 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ff7d00;text-align:center;vertical-align:middle;">0.25</td><td headers="hd_h_ch2.appg.tab24_1_1_1_10 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ff4500;text-align:center;vertical-align:middle;">0.14</td><td headers="hd_h_ch2.appg.tab24_1_1_1_11 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#fffd00;text-align:center;vertical-align:middle;">0.50</td><td headers="hd_h_ch2.appg.tab24_1_1_1_12 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ff9000;text-align:center;vertical-align:middle;">0.28</td><td headers="hd_h_ch2.appg.tab24_1_1_1_13 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ff9500;text-align:center;vertical-align:middle;">0.29</td><td headers="hd_h_ch2.appg.tab24_1_1_1_14 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ff8c00;text-align:center;vertical-align:middle;">0.27</td><td headers="hd_h_ch2.appg.tab24_1_1_1_15 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ffb900;text-align:center;vertical-align:middle;">0.36</td><td headers="hd_h_ch2.appg.tab24_1_1_1_16 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ff9e00;text-align:center;vertical-align:middle;">0.31</td><td headers="hd_h_ch2.appg.tab24_1_1_1_17 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#ffd000;text-align:center;vertical-align:middle;">0.41</td><td headers="hd_h_ch2.appg.tab24_1_1_1_18 hd_b_ch2.appg.tab24_1_1_18_1" rowspan="1" colspan="1" style="background-color:#b7b7b7;text-align:center;vertical-align:middle;"></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appgtab25"><div id="ch2.appg.tab25" class="table"><h3><span class="label">Table 36</span><span class="title">Age 5–11, Severe. Depressive Symptoms Post Treatment (pairwise probability more effective)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appg.tab25/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appg.tab25_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appg.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;"></th><th id="hd_h_ch2.appg.tab25_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family IPT</th><th id="hd_h_ch2.appg.tab25_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">NDST</th><th id="hd_h_ch2.appg.tab25_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family Therapy</th><th id="hd_h_ch2.appg.tab25_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Psychodynamic Psychotherapy</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appg.tab25_1_1_1_1" id="hd_b_ch2.appg.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family IPT</th><td headers="hd_h_ch2.appg.tab25_1_1_1_2 hd_b_ch2.appg.tab25_1_1_1_1" rowspan="1" colspan="1" style="background-color:#959595;text-align:right;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab25_1_1_1_3 hd_b_ch2.appg.tab25_1_1_1_1" rowspan="1" colspan="1" style="background-color:#f8746d;text-align:right;vertical-align:middle;">0.05</td><td headers="hd_h_ch2.appg.tab25_1_1_1_4 hd_b_ch2.appg.tab25_1_1_1_1" rowspan="1" colspan="1" style="background-color:#fba977;text-align:right;vertical-align:middle;">0.25</td><td headers="hd_h_ch2.appg.tab25_1_1_1_5 hd_b_ch2.appg.tab25_1_1_1_1" rowspan="1" colspan="1" style="background-color:#f86c6b;text-align:right;vertical-align:middle;">0.02</td></tr><tr><th headers="hd_h_ch2.appg.tab25_1_1_1_1" id="hd_b_ch2.appg.tab25_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">NDST</th><td headers="hd_h_ch2.appg.tab25_1_1_1_2 hd_b_ch2.appg.tab25_1_1_2_1" rowspan="1" colspan="1" style="background-color:#71c27c;text-align:right;vertical-align:middle;">0.95</td><td headers="hd_h_ch2.appg.tab25_1_1_1_3 hd_b_ch2.appg.tab25_1_1_2_1" rowspan="1" colspan="1" style="background-color:#959595;text-align:right;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab25_1_1_1_4 hd_b_ch2.appg.tab25_1_1_2_1" rowspan="1" colspan="1" style="background-color:#83c77d;text-align:right;vertical-align:middle;">0.90</td><td headers="hd_h_ch2.appg.tab25_1_1_1_5 hd_b_ch2.appg.tab25_1_1_2_1" rowspan="1" colspan="1" style="background-color:#f9826f;text-align:right;vertical-align:middle;">0.10</td></tr><tr><th headers="hd_h_ch2.appg.tab25_1_1_1_1" id="hd_b_ch2.appg.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family Therapy</th><td headers="hd_h_ch2.appg.tab25_1_1_1_2 hd_b_ch2.appg.tab25_1_1_3_1" rowspan="1" colspan="1" style="background-color:#b1d580;text-align:right;vertical-align:middle;">0.75</td><td headers="hd_h_ch2.appg.tab25_1_1_1_3 hd_b_ch2.appg.tab25_1_1_3_1" rowspan="1" colspan="1" style="background-color:#f9826f;text-align:right;vertical-align:middle;">0.10</td><td headers="hd_h_ch2.appg.tab25_1_1_1_4 hd_b_ch2.appg.tab25_1_1_3_1" rowspan="1" colspan="1" style="background-color:#959595;text-align:right;vertical-align:middle;"></td><td headers="hd_h_ch2.appg.tab25_1_1_1_5 hd_b_ch2.appg.tab25_1_1_3_1" rowspan="1" colspan="1" style="background-color:#f8696b;text-align:right;vertical-align:middle;">0.00</td></tr><tr><th headers="hd_h_ch2.appg.tab25_1_1_1_1" id="hd_b_ch2.appg.tab25_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Psychodynamic Psychotherapy</th><td headers="hd_h_ch2.appg.tab25_1_1_1_2 hd_b_ch2.appg.tab25_1_1_4_1" rowspan="1" colspan="1" style="background-color:#68c07c;color:#ffffff;text-align:right;vertical-align:middle;">
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<b>0.98</b>
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</td><td headers="hd_h_ch2.appg.tab25_1_1_1_3 hd_b_ch2.appg.tab25_1_1_4_1" rowspan="1" colspan="1" style="background-color:#82c77d;text-align:right;vertical-align:middle;">0.90</td><td headers="hd_h_ch2.appg.tab25_1_1_1_4 hd_b_ch2.appg.tab25_1_1_4_1" rowspan="1" colspan="1" style="background-color:#63be7b;color:#ffffff;text-align:right;vertical-align:middle;">
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<b>1.00</b>
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</td><td headers="hd_h_ch2.appg.tab25_1_1_1_5 hd_b_ch2.appg.tab25_1_1_4_1" rowspan="1" colspan="1" style="background-color:#959595;text-align:right;vertical-align:middle;"></td></tr></tbody></table></div></div></article><article data-type="fig" id="figobch2appgfig64"><div id="ch2.appg.fig64" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appgf63&p=BOOKS&id=557360_ch2appgf63.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf63.jpg" alt="Image ch2appgf63" class="tileshop" title="Click on image to zoom" /></a></div></div></article><article data-type="fig" id="figobch2appgfig65"><div id="ch2.appg.fig65" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appgf64&p=BOOKS&id=557360_ch2appgf64.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf64.jpg" alt="Image ch2appgf64" class="tileshop" title="Click on image to zoom" /></a></div></div></article><article data-type="fig" id="figobch2appgfig66"><div id="ch2.appg.fig66" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appgf65&p=BOOKS&id=557360_ch2appgf65.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appgf65.jpg" alt="Image ch2appgf65" class="tileshop" title="Click on image to zoom" /></a></div></div></article><article data-type="table-wrap" id="figobch2apphtab1"><div id="ch2.apph.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab1_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab1_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab1_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab1_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab1_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab1_1_1_1_1 hd_h_ch2.apph.tab1_1_1_1_2 hd_h_ch2.apph.tab1_1_1_1_3 hd_h_ch2.apph.tab1_1_1_1_4 hd_h_ch2.apph.tab1_1_1_1_5 hd_h_ch2.apph.tab1_1_1_1_6 hd_h_ch2.apph.tab1_1_1_1_7 hd_h_ch2.apph.tab1_1_1_1_8 hd_h_ch2.apph.tab1_1_1_1_9 hd_h_ch2.apph.tab1_1_1_1_10 hd_h_ch2.apph.tab1_1_1_1_11" id="hd_b_ch2.apph.tab1_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab1_1_1_1_1 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref63" rid="ch2.appo.ref63">Stark 1987</a>, <a class="bibr" href="#ch2.appo.ref77" rid="ch2.appo.ref77">Weisz 1997</a>)</td><td headers="hd_h_ch2.apph.tab1_1_1_1_2 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab1_1_1_1_3 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47</td><td headers="hd_h_ch2.apph.tab1_1_1_1_4 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.95</p>
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<p>(−1.59, −0.32)</p>
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</td><td headers="hd_h_ch2.apph.tab1_1_1_1_5 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−8.23</p>
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<p>(−13.78, −2.77)</p>
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</td><td headers="hd_h_ch2.apph.tab1_1_1_1_6 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab1_1_1_1_7 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab1_1_1_1_8 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab1_1_1_1_9 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab1_1_1_1_10 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab1_1_1_1_11 hd_b_ch2.apph.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab1_1_1_1_1 hd_h_ch2.apph.tab1_1_1_1_2 hd_h_ch2.apph.tab1_1_1_1_3 hd_h_ch2.apph.tab1_1_1_1_4 hd_h_ch2.apph.tab1_1_1_1_5 hd_h_ch2.apph.tab1_1_1_1_6 hd_h_ch2.apph.tab1_1_1_1_7 hd_h_ch2.apph.tab1_1_1_1_8 hd_h_ch2.apph.tab1_1_1_1_9 hd_h_ch2.apph.tab1_1_1_1_10 hd_h_ch2.apph.tab1_1_1_1_11" id="hd_b_ch2.apph.tab1_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS-R (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab1_1_1_1_1 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref77" rid="ch2.appo.ref77">Weisz 1997</a>)</td><td headers="hd_h_ch2.apph.tab1_1_1_1_2 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab1_1_1_1_3 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29</td><td headers="hd_h_ch2.apph.tab1_1_1_1_4 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.62</p>
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<p>(−1.41, 0.16)</p>
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</td><td headers="hd_h_ch2.apph.tab1_1_1_1_5 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−5.37</p>
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<p>(−12.22, 1.39)</p>
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</td><td headers="hd_h_ch2.apph.tab1_1_1_1_6 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab1_1_1_1_7 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab1_1_1_1_8 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab1_1_1_1_9 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab1_1_1_1_10 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab1_1_1_1_11 hd_b_ch2.apph.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab1_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab1_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab1_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab2"><div id="ch2.apph.tab2" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab2_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab2_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab2_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab2_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab2_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab2_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab2_1_1_1_1 hd_h_ch2.apph.tab2_1_1_1_2 hd_h_ch2.apph.tab2_1_1_1_3 hd_h_ch2.apph.tab2_1_1_1_4 hd_h_ch2.apph.tab2_1_1_1_5 hd_h_ch2.apph.tab2_1_1_1_6 hd_h_ch2.apph.tab2_1_1_1_7 hd_h_ch2.apph.tab2_1_1_1_8 hd_h_ch2.apph.tab2_1_1_1_9 hd_h_ch2.apph.tab2_1_1_1_10 hd_h_ch2.apph.tab2_1_1_1_11" id="hd_b_ch2.apph.tab2_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab2_1_1_1_1 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref5" rid="ch2.appo.ref5">Bella-Awusah 2015</a>, <a class="bibr" href="#ch2.appo.ref15" rid="ch2.appo.ref15">De Cuyper 2004</a>)</td><td headers="hd_h_ch2.apph.tab2_1_1_1_2 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab2_1_1_1_3 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60</td><td headers="hd_h_ch2.apph.tab2_1_1_1_4 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.52</p>
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<p>(−1.81, 0.77)</p>
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</td><td headers="hd_h_ch2.apph.tab2_1_1_1_5 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−4.51</p>
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<p>(−15.69, 6.67)</p>
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</td><td headers="hd_h_ch2.apph.tab2_1_1_1_6 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab2_1_1_1_7 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab2_1_1_1_8 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab2_1_1_1_9 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab2_1_1_1_10 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab2_1_1_1_11 hd_b_ch2.apph.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab2_1_1_1_1 hd_h_ch2.apph.tab2_1_1_1_2 hd_h_ch2.apph.tab2_1_1_1_3 hd_h_ch2.apph.tab2_1_1_1_4 hd_h_ch2.apph.tab2_1_1_1_5 hd_h_ch2.apph.tab2_1_1_1_6 hd_h_ch2.apph.tab2_1_1_1_7 hd_h_ch2.apph.tab2_1_1_1_8 hd_h_ch2.apph.tab2_1_1_1_9 hd_h_ch2.apph.tab2_1_1_1_10 hd_h_ch2.apph.tab2_1_1_1_11" id="hd_b_ch2.apph.tab2_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab2_1_1_1_1 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref15" rid="ch2.appo.ref15">De Cuyper 2004</a>, <a class="bibr" href="#ch2.appo.ref25" rid="ch2.appo.ref25">Gaete 2016</a>)</td><td headers="hd_h_ch2.apph.tab2_1_1_1_2 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab2_1_1_1_3 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">299</td><td headers="hd_h_ch2.apph.tab2_1_1_1_4 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.11</p>
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<p>(−0.35, 0.13)</p>
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</td><td headers="hd_h_ch2.apph.tab2_1_1_1_5 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−0.95</p>
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<p>(−3.03, 1.13)</p>
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</td><td headers="hd_h_ch2.apph.tab2_1_1_1_6 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab2_1_1_1_7 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab2_1_1_1_8 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab2_1_1_1_9 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab2_1_1_1_10 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab2_1_1_1_11 hd_b_ch2.apph.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab2_1_1_1_1 hd_h_ch2.apph.tab2_1_1_1_2 hd_h_ch2.apph.tab2_1_1_1_3 hd_h_ch2.apph.tab2_1_1_1_4 hd_h_ch2.apph.tab2_1_1_1_5 hd_h_ch2.apph.tab2_1_1_1_6 hd_h_ch2.apph.tab2_1_1_1_7 hd_h_ch2.apph.tab2_1_1_1_8 hd_h_ch2.apph.tab2_1_1_1_9 hd_h_ch2.apph.tab2_1_1_1_10 hd_h_ch2.apph.tab2_1_1_1_11" id="hd_b_ch2.apph.tab2_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab2_1_1_1_1 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2<sup>**</sup> (<a class="bibr" href="#ch2.appo.ref15" rid="ch2.appo.ref15">De Cuyper 2004</a>, <a class="bibr" href="#ch2.appo.ref25" rid="ch2.appo.ref25">Gaete 2016</a>)</td><td headers="hd_h_ch2.apph.tab2_1_1_1_2 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab2_1_1_1_3 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">362</td><td headers="hd_h_ch2.apph.tab2_1_1_1_4 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>RR 0.99</p>
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<p>(0.62, 1.58)</p>
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</td><td headers="hd_h_ch2.apph.tab2_1_1_1_5 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab2_1_1_1_6 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19 per 100</td><td headers="hd_h_ch2.apph.tab2_1_1_1_7 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>18 per 100</p>
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<p>(12, 29)</p>
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</td><td headers="hd_h_ch2.apph.tab2_1_1_1_8 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab2_1_1_1_9 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab2_1_1_1_10 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab2_1_1_1_11 hd_b_ch2.apph.tab2_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab2_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab2_2"><p class="no_margin">One study had no events in either arm and so only one study contributed to the analysis</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab2_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab2_4"><p class="no_margin">I<sup>2</sup> is greater than 66.7%</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab2_5"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab3"><div id="ch2.apph.tab3" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab3_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab3_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab3_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab3_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab3_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab3_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab3_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab3_1_1_1_1 hd_h_ch2.apph.tab3_1_1_1_2 hd_h_ch2.apph.tab3_1_1_1_3 hd_h_ch2.apph.tab3_1_1_1_4 hd_h_ch2.apph.tab3_1_1_1_5 hd_h_ch2.apph.tab3_1_1_1_6 hd_h_ch2.apph.tab3_1_1_1_7 hd_h_ch2.apph.tab3_1_1_1_8 hd_h_ch2.apph.tab3_1_1_1_9 hd_h_ch2.apph.tab3_1_1_1_10 hd_h_ch2.apph.tab3_1_1_1_11" id="hd_b_ch2.apph.tab3_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab3_1_1_1_1 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref5" rid="ch2.appo.ref5">Bella-Awusah 2015</a>)</td><td headers="hd_h_ch2.apph.tab3_1_1_1_2 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab3_1_1_1_3 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_ch2.apph.tab3_1_1_1_4 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −1.15</p>
|
|
<p>(−1.82, −0.48)</p>
|
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</td><td headers="hd_h_ch2.apph.tab3_1_1_1_5 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
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<p>−9.97</p>
|
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<p>(−15.77, −4.16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab3_1_1_1_6 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab3_1_1_1_7 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab3_1_1_1_8 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab3_1_1_1_9 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab3_1_1_1_10 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab3_1_1_1_11 hd_b_ch2.apph.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab3_1_1_1_1 hd_h_ch2.apph.tab3_1_1_1_2 hd_h_ch2.apph.tab3_1_1_1_3 hd_h_ch2.apph.tab3_1_1_1_4 hd_h_ch2.apph.tab3_1_1_1_5 hd_h_ch2.apph.tab3_1_1_1_6 hd_h_ch2.apph.tab3_1_1_1_7 hd_h_ch2.apph.tab3_1_1_1_8 hd_h_ch2.apph.tab3_1_1_1_9 hd_h_ch2.apph.tab3_1_1_1_10 hd_h_ch2.apph.tab3_1_1_1_11" id="hd_b_ch2.apph.tab3_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI-II (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab3_1_1_1_1 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref25" rid="ch2.appo.ref25">Gaete 2016</a>)</td><td headers="hd_h_ch2.apph.tab3_1_1_1_2 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab3_1_1_1_3 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">279</td><td headers="hd_h_ch2.apph.tab3_1_1_1_4 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.73</p>
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<p>(−3.14, 1.68)</p>
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</td><td headers="hd_h_ch2.apph.tab3_1_1_1_5 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−6.33</p>
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<p>(−27.21, 14.56)</p>
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</td><td headers="hd_h_ch2.apph.tab3_1_1_1_6 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab3_1_1_1_7 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab3_1_1_1_8 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab3_1_1_1_9 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab3_1_1_1_10 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab3_1_1_1_11 hd_b_ch2.apph.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab3_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab3_2"><p class="no_margin">>33.3% of weighted data from study at moderate risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab3_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab4"><div id="ch2.apph.tab4" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab4_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab4_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab4_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab4_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab4_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab4_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab4_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab4_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup: With comorbidity (IBS), Functional status, CGAS (values higher than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy 2007</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>MD 6.90</p>
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|
<p>(1.89, 11.91)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>4</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup: With comorbidity (IBS), Functional status, CGAS (values higher than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy 2007</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 5.90</p>
|
|
<p>(1.93, 9.87)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>4</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup: With comorbidity (IBS), Functional status, CGAS (values higher than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy 2007</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>MD 3.70</p>
|
|
<p>(−0.93, 8.33)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>4</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Main analysis: Depression symptoms (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref30" rid="ch2.appo.ref30">Hayes 2011</a>, <a class="bibr" href="#ch2.appo.ref43" rid="ch2.appo.ref43">Listug-Lunde 2013</a>, <a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy 2007</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.50</p>
|
|
<p>(−0.94, −0.06)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
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<p>MD −4.33</p>
|
|
<p>(−8.15, −0.52)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>6</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very Low</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup: With comorbidity (IBS), Depression symptoms (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref67" rid="ch2.appo.ref67">Szigethy 2007</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.99</p>
|
|
<p>(−1.65, −0.33)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>MD −8.58</p>
|
|
<p>(−14.3, −2.86)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>4</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup: Without comorbidity, Depression symptoms (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref30" rid="ch2.appo.ref30">Hayes 2011</a>, <a class="bibr" href="#ch2.appo.ref43" rid="ch2.appo.ref43">Listug-Lunde 2013</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.11</p>
|
|
<p>(−0.07, 0.49)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>MD −0.95</p>
|
|
<p>(−0.61, 4.25)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref30" rid="ch2.appo.ref30">Hayes 2011</a>, <a class="bibr" href="#ch2.appo.ref43" rid="ch2.appo.ref43">Listug-Lunde 2013</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.65</p>
|
|
<p>(−2.72, 1.42)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−5.63</p>
|
|
<p>(−23.57, 12.31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>6</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_15_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref31" rid="ch2.appo.ref31">Hogberg 2018</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.67</p>
|
|
<p>(0.94, 7.57)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25 per 100</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>67 per 100</p>
|
|
<p>(24, 189)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>4</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_17_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation (values lower than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref31" rid="ch2.appo.ref31">Hogberg 2018</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.12</p>
|
|
<p>(0.01, 2.05)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25 per 100</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>3 per 100</p>
|
|
<p>(0, 51)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>4</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_h_ch2.apph.tab4_1_1_1_2 hd_h_ch2.apph.tab4_1_1_1_3 hd_h_ch2.apph.tab4_1_1_1_4 hd_h_ch2.apph.tab4_1_1_1_5 hd_h_ch2.apph.tab4_1_1_1_6 hd_h_ch2.apph.tab4_1_1_1_7 hd_h_ch2.apph.tab4_1_1_1_8 hd_h_ch2.apph.tab4_1_1_1_9 hd_h_ch2.apph.tab4_1_1_1_10 hd_h_ch2.apph.tab4_1_1_1_11" id="hd_b_ch2.apph.tab4_1_1_19_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab4_1_1_1_1 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3<sup>**</sup> (<a class="bibr" href="#ch2.appo.ref8" rid="ch2.appo.ref8">Brent 2015</a>, <a class="bibr" href="#ch2.appo.ref30" rid="ch2.appo.ref30">Hayes 2011</a>, <a class="bibr" href="#ch2.appo.ref31" rid="ch2.appo.ref31">Hogberg 2018</a>)</td><td headers="hd_h_ch2.apph.tab4_1_1_1_2 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab4_1_1_1_3 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">367</td><td headers="hd_h_ch2.apph.tab4_1_1_1_4 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.74</p>
|
|
<p>(0.47, 1.18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_5 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab4_1_1_1_6 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 per 100</td><td headers="hd_h_ch2.apph.tab4_1_1_1_7 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>7 per 100</p>
|
|
<p>(4, 11)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab4_1_1_1_8 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab4_1_1_1_9 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_10 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab4_1_1_1_11 hd_b_ch2.apph.tab4_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab4_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab4_2"><p class="no_margin">One study had no events in either arm and so only two studies contributed to the analysis IBS: irritable bowel syndrome</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab4_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab4_4"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab4_5"><p class="no_margin">>33.3% of weighted data from studies which are partially directly applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch2.apph.tab4_6"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>5</dt><dd><div id="ch2.apph.tab4_7"><p class="no_margin">I<sup>2</sup> is greater than 33.3%</p></div></dd></dl><dl class="bkr_refwrap"><dt>6</dt><dd><div id="ch2.apph.tab4_8"><p class="no_margin">I<sup>2</sup> is greater than 66.7%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab5"><div id="ch2.apph.tab5" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab5_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab5_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab5_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab5_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab5_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab5_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab5_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab5_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab5_1_1_1_1 hd_h_ch2.apph.tab5_1_1_1_2 hd_h_ch2.apph.tab5_1_1_1_3 hd_h_ch2.apph.tab5_1_1_1_4 hd_h_ch2.apph.tab5_1_1_1_5 hd_h_ch2.apph.tab5_1_1_1_6 hd_h_ch2.apph.tab5_1_1_1_7 hd_h_ch2.apph.tab5_1_1_1_8 hd_h_ch2.apph.tab5_1_1_1_9 hd_h_ch2.apph.tab5_1_1_1_10 hd_h_ch2.apph.tab5_1_1_1_11" id="hd_b_ch2.apph.tab5_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab5_1_1_1_1 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref43" rid="ch2.appo.ref43">Listug-Lunde 2013</a>)</td><td headers="hd_h_ch2.apph.tab5_1_1_1_2 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab5_1_1_1_3 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16</td><td headers="hd_h_ch2.apph.tab5_1_1_1_4 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 0.50</p>
|
|
<p>(−7.92, 8.92)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab5_1_1_1_5 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab5_1_1_1_6 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab5_1_1_1_7 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab5_1_1_1_8 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab5_1_1_1_9 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab5_1_1_1_10 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab5_1_1_1_11 hd_b_ch2.apph.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab5_1_1_1_1 hd_h_ch2.apph.tab5_1_1_1_2 hd_h_ch2.apph.tab5_1_1_1_3 hd_h_ch2.apph.tab5_1_1_1_4 hd_h_ch2.apph.tab5_1_1_1_5 hd_h_ch2.apph.tab5_1_1_1_6 hd_h_ch2.apph.tab5_1_1_1_7 hd_h_ch2.apph.tab5_1_1_1_8 hd_h_ch2.apph.tab5_1_1_1_9 hd_h_ch2.apph.tab5_1_1_1_10 hd_h_ch2.apph.tab5_1_1_1_11" id="hd_b_ch2.apph.tab5_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab5_1_1_1_1 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref43" rid="ch2.appo.ref43">Listug-Lunde 2013</a>)</td><td headers="hd_h_ch2.apph.tab5_1_1_1_2 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab5_1_1_1_3 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16</td><td headers="hd_h_ch2.apph.tab5_1_1_1_4 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 2.25</p>
|
|
<p>(−4.04, 8.54)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab5_1_1_1_5 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab5_1_1_1_6 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab5_1_1_1_7 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab5_1_1_1_8 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab5_1_1_1_9 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab5_1_1_1_10 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab5_1_1_1_11 hd_b_ch2.apph.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab5_1_1_1_1 hd_h_ch2.apph.tab5_1_1_1_2 hd_h_ch2.apph.tab5_1_1_1_3 hd_h_ch2.apph.tab5_1_1_1_4 hd_h_ch2.apph.tab5_1_1_1_5 hd_h_ch2.apph.tab5_1_1_1_6 hd_h_ch2.apph.tab5_1_1_1_7 hd_h_ch2.apph.tab5_1_1_1_8 hd_h_ch2.apph.tab5_1_1_1_9 hd_h_ch2.apph.tab5_1_1_1_10 hd_h_ch2.apph.tab5_1_1_1_11" id="hd_b_ch2.apph.tab5_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab5_1_1_1_1 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref8" rid="ch2.appo.ref8">Brent 2015</a>)</td><td headers="hd_h_ch2.apph.tab5_1_1_1_2 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab5_1_1_1_3 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">302</td><td headers="hd_h_ch2.apph.tab5_1_1_1_4 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.43</p>
|
|
<p>(0.09, 2.20)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab5_1_1_1_5 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab5_1_1_1_6 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 per 100</td><td headers="hd_h_ch2.apph.tab5_1_1_1_7 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>1 per 100</p>
|
|
<p>(0, 7)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab5_1_1_1_8 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab5_1_1_1_9 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab5_1_1_1_10 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab5_1_1_1_11 hd_b_ch2.apph.tab5_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab5_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab5_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab5_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab6"><div id="ch2.apph.tab6" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab6_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab6_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: NDST</th><th id="hd_h_ch2.apph.tab6_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: CBT (95% CI)</th><th id="hd_h_ch2.apph.tab6_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab6_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab6_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab6_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab6_1_1_1_1 hd_h_ch2.apph.tab6_1_1_1_2 hd_h_ch2.apph.tab6_1_1_1_3 hd_h_ch2.apph.tab6_1_1_1_4 hd_h_ch2.apph.tab6_1_1_1_5 hd_h_ch2.apph.tab6_1_1_1_6 hd_h_ch2.apph.tab6_1_1_1_7 hd_h_ch2.apph.tab6_1_1_1_8 hd_h_ch2.apph.tab6_1_1_1_9 hd_h_ch2.apph.tab6_1_1_1_10 hd_h_ch2.apph.tab6_1_1_1_11" id="hd_b_ch2.apph.tab6_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab6_1_1_1_1 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref20" rid="ch2.appo.ref20">Duong 2016</a>)</td><td headers="hd_h_ch2.apph.tab6_1_1_1_2 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab6_1_1_1_3 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">110</td><td headers="hd_h_ch2.apph.tab6_1_1_1_4 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.46</p>
|
|
<p>(−0.82, −0.10)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab6_1_1_1_5 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.99</p>
|
|
<p>(−7.11, −0.87)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab6_1_1_1_6 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab6_1_1_1_7 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab6_1_1_1_8 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab6_1_1_1_9 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab6_1_1_1_10 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab6_1_1_1_11 hd_b_ch2.apph.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab6_1_1_1_1 hd_h_ch2.apph.tab6_1_1_1_2 hd_h_ch2.apph.tab6_1_1_1_3 hd_h_ch2.apph.tab6_1_1_1_4 hd_h_ch2.apph.tab6_1_1_1_5 hd_h_ch2.apph.tab6_1_1_1_6 hd_h_ch2.apph.tab6_1_1_1_7 hd_h_ch2.apph.tab6_1_1_1_8 hd_h_ch2.apph.tab6_1_1_1_9 hd_h_ch2.apph.tab6_1_1_1_10 hd_h_ch2.apph.tab6_1_1_1_11" id="hd_b_ch2.apph.tab6_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab6_1_1_1_1 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref20" rid="ch2.appo.ref20">Duong 2016</a>)</td><td headers="hd_h_ch2.apph.tab6_1_1_1_2 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab6_1_1_1_3 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">110</td><td headers="hd_h_ch2.apph.tab6_1_1_1_4 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.34</p>
|
|
<p>(−0.70, 0.02)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab6_1_1_1_5 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.95</p>
|
|
<p>(−6.07, 0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab6_1_1_1_6 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab6_1_1_1_7 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab6_1_1_1_8 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab6_1_1_1_9 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab6_1_1_1_10 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab6_1_1_1_11 hd_b_ch2.apph.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab6_1_1_1_1 hd_h_ch2.apph.tab6_1_1_1_2 hd_h_ch2.apph.tab6_1_1_1_3 hd_h_ch2.apph.tab6_1_1_1_4 hd_h_ch2.apph.tab6_1_1_1_5 hd_h_ch2.apph.tab6_1_1_1_6 hd_h_ch2.apph.tab6_1_1_1_7 hd_h_ch2.apph.tab6_1_1_1_8 hd_h_ch2.apph.tab6_1_1_1_9 hd_h_ch2.apph.tab6_1_1_1_10 hd_h_ch2.apph.tab6_1_1_1_11" id="hd_b_ch2.apph.tab6_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab6_1_1_1_1 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref20" rid="ch2.appo.ref20">Duong 2016</a>)</td><td headers="hd_h_ch2.apph.tab6_1_1_1_2 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab6_1_1_1_3 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">110</td><td headers="hd_h_ch2.apph.tab6_1_1_1_4 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.31</p>
|
|
<p>(−0.67, 0.05)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab6_1_1_1_5 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.69</p>
|
|
<p>(−5.81, 0.43)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab6_1_1_1_6 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab6_1_1_1_7 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab6_1_1_1_8 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab6_1_1_1_9 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab6_1_1_1_10 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab6_1_1_1_11 hd_b_ch2.apph.tab6_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab6_1_1_1_1 hd_h_ch2.apph.tab6_1_1_1_2 hd_h_ch2.apph.tab6_1_1_1_3 hd_h_ch2.apph.tab6_1_1_1_4 hd_h_ch2.apph.tab6_1_1_1_5 hd_h_ch2.apph.tab6_1_1_1_6 hd_h_ch2.apph.tab6_1_1_1_7 hd_h_ch2.apph.tab6_1_1_1_8 hd_h_ch2.apph.tab6_1_1_1_9 hd_h_ch2.apph.tab6_1_1_1_10 hd_h_ch2.apph.tab6_1_1_1_11" id="hd_b_ch2.apph.tab6_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab6_1_1_1_1 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref20" rid="ch2.appo.ref20">Duong 2016</a>)</td><td headers="hd_h_ch2.apph.tab6_1_1_1_2 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab6_1_1_1_3 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">110</td><td headers="hd_h_ch2.apph.tab6_1_1_1_4 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.72</p>
|
|
<p>(0.20, 2.53)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab6_1_1_1_5 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab6_1_1_1_6 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10 per 100</td><td headers="hd_h_ch2.apph.tab6_1_1_1_7 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>7 per 100</p>
|
|
<p>(2, 24)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab6_1_1_1_8 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab6_1_1_1_9 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab6_1_1_1_10 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab6_1_1_1_11 hd_b_ch2.apph.tab6_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab6_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab6_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab6_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab7"><div id="ch2.apph.tab7" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab7_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab7_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab7_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab7_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab7_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab7_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab7_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab7_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab7_1_1_1_1 hd_h_ch2.apph.tab7_1_1_1_2 hd_h_ch2.apph.tab7_1_1_1_3 hd_h_ch2.apph.tab7_1_1_1_4 hd_h_ch2.apph.tab7_1_1_1_5 hd_h_ch2.apph.tab7_1_1_1_6 hd_h_ch2.apph.tab7_1_1_1_7 hd_h_ch2.apph.tab7_1_1_1_8 hd_h_ch2.apph.tab7_1_1_1_9 hd_h_ch2.apph.tab7_1_1_1_10 hd_h_ch2.apph.tab7_1_1_1_11" id="hd_b_ch2.apph.tab7_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour individual CBT and family education) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab7_1_1_1_1 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref4" rid="ch2.appo.ref4">Asarnow 2002</a>)</td><td headers="hd_h_ch2.apph.tab7_1_1_1_2 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab7_1_1_1_3 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23</td><td headers="hd_h_ch2.apph.tab7_1_1_1_4 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −2.79</p>
|
|
<p>(−10.21, 4.63)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab7_1_1_1_5 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td><td headers="hd_h_ch2.apph.tab7_1_1_1_6 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab7_1_1_1_7 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab7_1_1_1_8 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab7_1_1_1_9 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab7_1_1_1_10 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td><td headers="hd_h_ch2.apph.tab7_1_1_1_11 hd_b_ch2.apph.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab7_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab8"><div id="ch2.apph.tab8" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab8_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab8_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab8_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab8_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab8_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab8_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab8_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab8_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab8_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab8_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_h_ch2.apph.tab8_1_1_1_2 hd_h_ch2.apph.tab8_1_1_1_3 hd_h_ch2.apph.tab8_1_1_1_4 hd_h_ch2.apph.tab8_1_1_1_5 hd_h_ch2.apph.tab8_1_1_1_6 hd_h_ch2.apph.tab8_1_1_1_7 hd_h_ch2.apph.tab8_1_1_1_8 hd_h_ch2.apph.tab8_1_1_1_9 hd_h_ch2.apph.tab8_1_1_1_10 hd_h_ch2.apph.tab8_1_1_1_11" id="hd_b_ch2.apph.tab8_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref32" rid="ch2.appo.ref32">Ip 2016</a>, <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>)</td><td headers="hd_h_ch2.apph.tab8_1_1_1_2 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab8_1_1_1_3 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">386</td><td headers="hd_h_ch2.apph.tab8_1_1_1_4 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.47</p>
|
|
<p>(−1.01, 0.07)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_5 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−4.07</p>
|
|
<p>(−8.75, 0.61)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_6 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_7 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_8 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_9 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_10 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab8_1_1_1_11 hd_b_ch2.apph.tab8_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_h_ch2.apph.tab8_1_1_1_2 hd_h_ch2.apph.tab8_1_1_1_3 hd_h_ch2.apph.tab8_1_1_1_4 hd_h_ch2.apph.tab8_1_1_1_5 hd_h_ch2.apph.tab8_1_1_1_6 hd_h_ch2.apph.tab8_1_1_1_7 hd_h_ch2.apph.tab8_1_1_1_8 hd_h_ch2.apph.tab8_1_1_1_9 hd_h_ch2.apph.tab8_1_1_1_10 hd_h_ch2.apph.tab8_1_1_1_11" id="hd_b_ch2.apph.tab8_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour computer CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>, <a class="bibr" href="#ch2.appo.ref81" rid="ch2.appo.ref81">Wright 2017</a>)</td><td headers="hd_h_ch2.apph.tab8_1_1_1_2 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab8_1_1_1_3 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">191</td><td headers="hd_h_ch2.apph.tab8_1_1_1_4 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.26</p>
|
|
<p>(−0.55, 0.02)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_5 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.25</p>
|
|
<p>(−4.77, 0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_6 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_7 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_8 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_9 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_10 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_11 hd_b_ch2.apph.tab8_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_h_ch2.apph.tab8_1_1_1_2 hd_h_ch2.apph.tab8_1_1_1_3 hd_h_ch2.apph.tab8_1_1_1_4 hd_h_ch2.apph.tab8_1_1_1_5 hd_h_ch2.apph.tab8_1_1_1_6 hd_h_ch2.apph.tab8_1_1_1_7 hd_h_ch2.apph.tab8_1_1_1_8 hd_h_ch2.apph.tab8_1_1_1_9 hd_h_ch2.apph.tab8_1_1_1_10 hd_h_ch2.apph.tab8_1_1_1_11" id="hd_b_ch2.apph.tab8_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour computer CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref32" rid="ch2.appo.ref32">Ip 2016</a>, <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab8_1_1_1_2 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab8_1_1_1_3 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">352</td><td headers="hd_h_ch2.apph.tab8_1_1_1_4 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.38</p>
|
|
<p>(−0.60, −0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_5 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.29</p>
|
|
<p>(−5.2, −1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_6 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_7 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_8 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_9 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_10 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_11 hd_b_ch2.apph.tab8_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_h_ch2.apph.tab8_1_1_1_2 hd_h_ch2.apph.tab8_1_1_1_3 hd_h_ch2.apph.tab8_1_1_1_4 hd_h_ch2.apph.tab8_1_1_1_5 hd_h_ch2.apph.tab8_1_1_1_6 hd_h_ch2.apph.tab8_1_1_1_7 hd_h_ch2.apph.tab8_1_1_1_8 hd_h_ch2.apph.tab8_1_1_1_9 hd_h_ch2.apph.tab8_1_1_1_10 hd_h_ch2.apph.tab8_1_1_1_11" id="hd_b_ch2.apph.tab8_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour computer CBT) – Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>)</td><td headers="hd_h_ch2.apph.tab8_1_1_1_2 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab8_1_1_1_3 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch2.apph.tab8_1_1_1_4 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.40</p>
|
|
<p>(0.59, 3.30)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_5 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_6 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36 per 100</td><td headers="hd_h_ch2.apph.tab8_1_1_1_7 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>50 per 100</p>
|
|
<p>(21, 118)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_8 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_9 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_10 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab8_1_1_1_11 hd_b_ch2.apph.tab8_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_h_ch2.apph.tab8_1_1_1_2 hd_h_ch2.apph.tab8_1_1_1_3 hd_h_ch2.apph.tab8_1_1_1_4 hd_h_ch2.apph.tab8_1_1_1_5 hd_h_ch2.apph.tab8_1_1_1_6 hd_h_ch2.apph.tab8_1_1_1_7 hd_h_ch2.apph.tab8_1_1_1_8 hd_h_ch2.apph.tab8_1_1_1_9 hd_h_ch2.apph.tab8_1_1_1_10 hd_h_ch2.apph.tab8_1_1_1_11" id="hd_b_ch2.apph.tab8_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, (scale -EQ-5D-Y) (values lower than 0 favour computer CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref81" rid="ch2.appo.ref81">Wright 2017</a>)</td><td headers="hd_h_ch2.apph.tab8_1_1_1_2 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab8_1_1_1_3 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52</td><td headers="hd_h_ch2.apph.tab8_1_1_1_4 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.00</p>
|
|
<p>(−0.54, 0.54)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_5 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>***</sup>HoNOSCA scale</p>
|
|
<p>0.00</p>
|
|
<p>(−3.5, 3.5)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_6 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_7 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_8 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab8_1_1_1_9 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_10 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab8_1_1_1_11 hd_b_ch2.apph.tab8_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_h_ch2.apph.tab8_1_1_1_2 hd_h_ch2.apph.tab8_1_1_1_3 hd_h_ch2.apph.tab8_1_1_1_4 hd_h_ch2.apph.tab8_1_1_1_5 hd_h_ch2.apph.tab8_1_1_1_6 hd_h_ch2.apph.tab8_1_1_1_7 hd_h_ch2.apph.tab8_1_1_1_8 hd_h_ch2.apph.tab8_1_1_1_9 hd_h_ch2.apph.tab8_1_1_1_10 hd_h_ch2.apph.tab8_1_1_1_11" id="hd_b_ch2.apph.tab8_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, CDI item 9 score 2 (values lower than 1 favour computer CBT) – Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab8_1_1_1_2 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab8_1_1_1_3 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">102</td><td headers="hd_h_ch2.apph.tab8_1_1_1_4 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.00</p>
|
|
<p>(0.06, 15.56)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_5 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_6 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 per 100</td><td headers="hd_h_ch2.apph.tab8_1_1_1_7 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2 per 100</p>
|
|
<p>(0, 31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_8 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_9 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_10 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab8_1_1_1_11 hd_b_ch2.apph.tab8_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_h_ch2.apph.tab8_1_1_1_2 hd_h_ch2.apph.tab8_1_1_1_3 hd_h_ch2.apph.tab8_1_1_1_4 hd_h_ch2.apph.tab8_1_1_1_5 hd_h_ch2.apph.tab8_1_1_1_6 hd_h_ch2.apph.tab8_1_1_1_7 hd_h_ch2.apph.tab8_1_1_1_8 hd_h_ch2.apph.tab8_1_1_1_9 hd_h_ch2.apph.tab8_1_1_1_10 hd_h_ch2.apph.tab8_1_1_1_11" id="hd_b_ch2.apph.tab8_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab8_1_1_1_1 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4 (<a class="bibr" href="#ch2.appo.ref32" rid="ch2.appo.ref32">Ip 2016</a>, <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>, <a class="bibr" href="#ch2.appo.ref81" rid="ch2.appo.ref81">Wright 2017</a>)</td><td headers="hd_h_ch2.apph.tab8_1_1_1_2 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab8_1_1_1_3 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">475</td><td headers="hd_h_ch2.apph.tab8_1_1_1_4 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.70</p>
|
|
<p>(0.62, 4.61)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_5 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab8_1_1_1_6 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 per 100</td><td headers="hd_h_ch2.apph.tab8_1_1_1_7 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>15 per 100</p>
|
|
<p>(6, 41)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab8_1_1_1_8 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab8_1_1_1_9 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab8_1_1_1_10 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>4</sup></td><td headers="hd_h_ch2.apph.tab8_1_1_1_11 hd_b_ch2.apph.tab8_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab8_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>***</dt><dd><div id="ch2.apph.tab8_2"><p class="no_margin">SMD to MD conversion on HoNOSCA scale using pooled SD for all studies using this scale (6.4787)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab8_3"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab8_4"><p class="no_margin">I<sup>2</sup> is greater than 66.7%</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab8_5"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch2.apph.tab8_6"><p class="no_margin">I<sup>2</sup> is greater than 33.3%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab9"><div id="ch2.apph.tab9" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab9/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab9_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab9_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab9_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab9_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab9_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab9_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab9_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab9_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab9_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab9_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab9_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab9_1_1_1_1 hd_h_ch2.apph.tab9_1_1_1_2 hd_h_ch2.apph.tab9_1_1_1_3 hd_h_ch2.apph.tab9_1_1_1_4 hd_h_ch2.apph.tab9_1_1_1_5 hd_h_ch2.apph.tab9_1_1_1_6 hd_h_ch2.apph.tab9_1_1_1_7 hd_h_ch2.apph.tab9_1_1_1_8 hd_h_ch2.apph.tab9_1_1_1_9 hd_h_ch2.apph.tab9_1_1_1_10 hd_h_ch2.apph.tab9_1_1_1_11" id="hd_b_ch2.apph.tab9_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour computer CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab9_1_1_1_1 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>)</td><td headers="hd_h_ch2.apph.tab9_1_1_1_2 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab9_1_1_1_3 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">136</td><td headers="hd_h_ch2.apph.tab9_1_1_1_4 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.17</p>
|
|
<p>(−0.50, 0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab9_1_1_1_5 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.47</p>
|
|
<p>(−4.33, 1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab9_1_1_1_6 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab9_1_1_1_7 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab9_1_1_1_8 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab9_1_1_1_9 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab9_1_1_1_10 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab9_1_1_1_11 hd_b_ch2.apph.tab9_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab9_1_1_1_1 hd_h_ch2.apph.tab9_1_1_1_2 hd_h_ch2.apph.tab9_1_1_1_3 hd_h_ch2.apph.tab9_1_1_1_4 hd_h_ch2.apph.tab9_1_1_1_5 hd_h_ch2.apph.tab9_1_1_1_6 hd_h_ch2.apph.tab9_1_1_1_7 hd_h_ch2.apph.tab9_1_1_1_8 hd_h_ch2.apph.tab9_1_1_1_9 hd_h_ch2.apph.tab9_1_1_1_10 hd_h_ch2.apph.tab9_1_1_1_11" id="hd_b_ch2.apph.tab9_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab9_1_1_1_1 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref32" rid="ch2.appo.ref32">Ip 2016</a>, <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref64" rid="ch2.appo.ref64">Stasiak 2014</a>)</td><td headers="hd_h_ch2.apph.tab9_1_1_1_2 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab9_1_1_1_3 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">392</td><td headers="hd_h_ch2.apph.tab9_1_1_1_4 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>RR 3.54</p>
|
|
<p>(0.35, 35.84)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab9_1_1_1_5 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab9_1_1_1_6 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 per 100</td><td headers="hd_h_ch2.apph.tab9_1_1_1_7 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>9 per 100</p>
|
|
<p>(1, 92)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab9_1_1_1_8 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab9_1_1_1_9 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab9_1_1_1_10 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious</td><td headers="hd_h_ch2.apph.tab9_1_1_1_11 hd_b_ch2.apph.tab9_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab9_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab9_2"><p class="no_margin">I<sup>2</sup> is greater than 66.7%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab10"><div id="ch2.apph.tab10" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab10/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab10_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab10_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab10_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab10_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab10_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab10_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab10_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab10_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab10_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab10_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab10_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab10_1_1_1_1 hd_h_ch2.apph.tab10_1_1_1_2 hd_h_ch2.apph.tab10_1_1_1_3 hd_h_ch2.apph.tab10_1_1_1_4 hd_h_ch2.apph.tab10_1_1_1_5 hd_h_ch2.apph.tab10_1_1_1_6 hd_h_ch2.apph.tab10_1_1_1_7 hd_h_ch2.apph.tab10_1_1_1_8 hd_h_ch2.apph.tab10_1_1_1_9 hd_h_ch2.apph.tab10_1_1_1_10 hd_h_ch2.apph.tab10_1_1_1_11" id="hd_b_ch2.apph.tab10_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab10_1_1_1_1 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab10_1_1_1_2 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab10_1_1_1_3 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">102</td><td headers="hd_h_ch2.apph.tab10_1_1_1_4 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.11</p>
|
|
<p>(−0.49, 0.28)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab10_1_1_1_5 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.95</p>
|
|
<p>(−4.25, 2.43)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab10_1_1_1_6 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab10_1_1_1_7 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab10_1_1_1_8 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab10_1_1_1_9 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab10_1_1_1_10 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab10_1_1_1_11 hd_b_ch2.apph.tab10_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab10_1_1_1_1 hd_h_ch2.apph.tab10_1_1_1_2 hd_h_ch2.apph.tab10_1_1_1_3 hd_h_ch2.apph.tab10_1_1_1_4 hd_h_ch2.apph.tab10_1_1_1_5 hd_h_ch2.apph.tab10_1_1_1_6 hd_h_ch2.apph.tab10_1_1_1_7 hd_h_ch2.apph.tab10_1_1_1_8 hd_h_ch2.apph.tab10_1_1_1_9 hd_h_ch2.apph.tab10_1_1_1_10 hd_h_ch2.apph.tab10_1_1_1_11" id="hd_b_ch2.apph.tab10_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour computer CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab10_1_1_1_1 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref81" rid="ch2.appo.ref81">Wright 2017</a>)</td><td headers="hd_h_ch2.apph.tab10_1_1_1_2 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab10_1_1_1_3 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">157</td><td headers="hd_h_ch2.apph.tab10_1_1_1_4 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.22</p>
|
|
<p>(−0.53, 0.10)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab10_1_1_1_5 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.91</p>
|
|
<p>(−4.59, 0.87)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab10_1_1_1_6 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab10_1_1_1_7 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab10_1_1_1_8 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab10_1_1_1_9 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab10_1_1_1_10 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious</td><td headers="hd_h_ch2.apph.tab10_1_1_1_11 hd_b_ch2.apph.tab10_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab10_1_1_1_1 hd_h_ch2.apph.tab10_1_1_1_2 hd_h_ch2.apph.tab10_1_1_1_3 hd_h_ch2.apph.tab10_1_1_1_4 hd_h_ch2.apph.tab10_1_1_1_5 hd_h_ch2.apph.tab10_1_1_1_6 hd_h_ch2.apph.tab10_1_1_1_7 hd_h_ch2.apph.tab10_1_1_1_8 hd_h_ch2.apph.tab10_1_1_1_9 hd_h_ch2.apph.tab10_1_1_1_10 hd_h_ch2.apph.tab10_1_1_1_11" id="hd_b_ch2.apph.tab10_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour computer CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab10_1_1_1_1 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab10_1_1_1_2 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab10_1_1_1_3 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">102</td><td headers="hd_h_ch2.apph.tab10_1_1_1_4 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.43</p>
|
|
<p>(−0.82, −0.03)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab10_1_1_1_5 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.73</p>
|
|
<p>(−7.11, −0.26)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab10_1_1_1_6 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab10_1_1_1_7 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab10_1_1_1_8 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab10_1_1_1_9 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab10_1_1_1_10 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab10_1_1_1_11 hd_b_ch2.apph.tab10_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab10_1_1_1_1 hd_h_ch2.apph.tab10_1_1_1_2 hd_h_ch2.apph.tab10_1_1_1_3 hd_h_ch2.apph.tab10_1_1_1_4 hd_h_ch2.apph.tab10_1_1_1_5 hd_h_ch2.apph.tab10_1_1_1_6 hd_h_ch2.apph.tab10_1_1_1_7 hd_h_ch2.apph.tab10_1_1_1_8 hd_h_ch2.apph.tab10_1_1_1_9 hd_h_ch2.apph.tab10_1_1_1_10 hd_h_ch2.apph.tab10_1_1_1_11" id="hd_b_ch2.apph.tab10_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab10_1_1_1_1 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref81" rid="ch2.appo.ref81">Wright 2017</a>)</td><td headers="hd_h_ch2.apph.tab10_1_1_1_2 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab10_1_1_1_3 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">184</td><td headers="hd_h_ch2.apph.tab10_1_1_1_4 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.51</p>
|
|
<p>(0.92, 2.48)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab10_1_1_1_5 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab10_1_1_1_6 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17 per 100</td><td headers="hd_h_ch2.apph.tab10_1_1_1_7 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>26 per 100</p>
|
|
<p>(16, 43)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab10_1_1_1_8 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab10_1_1_1_9 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab10_1_1_1_10 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab10_1_1_1_11 hd_b_ch2.apph.tab10_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab10_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab10_2"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab10_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab10_4"><p class="no_margin">I<sup>2</sup> is greater than 33.3%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab11"><div id="ch2.apph.tab11" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab11/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab11_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab11_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab11_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab11_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab11_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab11_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab11_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab11_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab11_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab11_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_h_ch2.apph.tab11_1_1_1_2 hd_h_ch2.apph.tab11_1_1_1_3 hd_h_ch2.apph.tab11_1_1_1_4 hd_h_ch2.apph.tab11_1_1_1_5 hd_h_ch2.apph.tab11_1_1_1_6 hd_h_ch2.apph.tab11_1_1_1_7 hd_h_ch2.apph.tab11_1_1_1_8 hd_h_ch2.apph.tab11_1_1_1_9 hd_h_ch2.apph.tab11_1_1_1_10 hd_h_ch2.apph.tab11_1_1_1_11" id="hd_b_ch2.apph.tab11_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref23" rid="ch2.appo.ref23">Fleming 2012</a>, <a class="bibr" href="#ch2.appo.ref60" rid="ch2.appo.ref60">Smith 2015</a>)</td><td headers="hd_h_ch2.apph.tab11_1_1_1_2 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab11_1_1_1_3 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">142</td><td headers="hd_h_ch2.apph.tab11_1_1_1_4 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −1.03</p>
|
|
<p>(−1.39, −0.68)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_5 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−8.93</p>
|
|
<p>(−12.05, −5.89)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_6 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab11_1_1_1_7 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab11_1_1_1_8 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab11_1_1_1_9 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab11_1_1_1_10 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab11_1_1_1_11 hd_b_ch2.apph.tab11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_h_ch2.apph.tab11_1_1_1_2 hd_h_ch2.apph.tab11_1_1_1_3 hd_h_ch2.apph.tab11_1_1_1_4 hd_h_ch2.apph.tab11_1_1_1_5 hd_h_ch2.apph.tab11_1_1_1_6 hd_h_ch2.apph.tab11_1_1_1_7 hd_h_ch2.apph.tab11_1_1_1_8 hd_h_ch2.apph.tab11_1_1_1_9 hd_h_ch2.apph.tab11_1_1_1_10 hd_h_ch2.apph.tab11_1_1_1_11" id="hd_b_ch2.apph.tab11_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref23" rid="ch2.appo.ref23">Fleming 2012</a>)</td><td headers="hd_h_ch2.apph.tab11_1_1_1_2 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab11_1_1_1_3 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch2.apph.tab11_1_1_1_4 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.17</p>
|
|
<p>(0.96, 4.91)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_5 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab11_1_1_1_6 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36 per 100</td><td headers="hd_h_ch2.apph.tab11_1_1_1_7 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>79 per 100</p>
|
|
<p>(35, 179)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_8 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab11_1_1_1_9 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab11_1_1_1_10 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab11_1_1_1_11 hd_b_ch2.apph.tab11_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_h_ch2.apph.tab11_1_1_1_2 hd_h_ch2.apph.tab11_1_1_1_3 hd_h_ch2.apph.tab11_1_1_1_4 hd_h_ch2.apph.tab11_1_1_1_5 hd_h_ch2.apph.tab11_1_1_1_6 hd_h_ch2.apph.tab11_1_1_1_7 hd_h_ch2.apph.tab11_1_1_1_8 hd_h_ch2.apph.tab11_1_1_1_9 hd_h_ch2.apph.tab11_1_1_1_10 hd_h_ch2.apph.tab11_1_1_1_11" id="hd_b_ch2.apph.tab11_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, PQ-LES-Q (values lower than 0 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref23" rid="ch2.appo.ref23">Fleming 2012</a>)</td><td headers="hd_h_ch2.apph.tab11_1_1_1_2 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab11_1_1_1_3 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch2.apph.tab11_1_1_1_4 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.05</p>
|
|
<p>(−0.69, 0.80)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_5 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>0.32</p>
|
|
<p>(−4.47, 5.18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_6 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab11_1_1_1_7 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab11_1_1_1_8 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab11_1_1_1_9 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab11_1_1_1_10 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab11_1_1_1_11 hd_b_ch2.apph.tab11_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_h_ch2.apph.tab11_1_1_1_2 hd_h_ch2.apph.tab11_1_1_1_3 hd_h_ch2.apph.tab11_1_1_1_4 hd_h_ch2.apph.tab11_1_1_1_5 hd_h_ch2.apph.tab11_1_1_1_6 hd_h_ch2.apph.tab11_1_1_1_7 hd_h_ch2.apph.tab11_1_1_1_8 hd_h_ch2.apph.tab11_1_1_1_9 hd_h_ch2.apph.tab11_1_1_1_10 hd_h_ch2.apph.tab11_1_1_1_11" id="hd_b_ch2.apph.tab11_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Self-harm (values lower than 1 favour computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref23" rid="ch2.appo.ref23">Fleming 2012</a>)</td><td headers="hd_h_ch2.apph.tab11_1_1_1_2 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab11_1_1_1_3 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch2.apph.tab11_1_1_1_4 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 3.00</p>
|
|
<p>(0.16, 57.36)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_5 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab11_1_1_1_6 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 per 100</td><td headers="hd_h_ch2.apph.tab11_1_1_1_7 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>14 per 100</p>
|
|
<p>(1, 261)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_8 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab11_1_1_1_9 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab11_1_1_1_10 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab11_1_1_1_11 hd_b_ch2.apph.tab11_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_h_ch2.apph.tab11_1_1_1_2 hd_h_ch2.apph.tab11_1_1_1_3 hd_h_ch2.apph.tab11_1_1_1_4 hd_h_ch2.apph.tab11_1_1_1_5 hd_h_ch2.apph.tab11_1_1_1_6 hd_h_ch2.apph.tab11_1_1_1_7 hd_h_ch2.apph.tab11_1_1_1_8 hd_h_ch2.apph.tab11_1_1_1_9 hd_h_ch2.apph.tab11_1_1_1_10 hd_h_ch2.apph.tab11_1_1_1_11" id="hd_b_ch2.apph.tab11_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab11_1_1_1_1 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2<sup>**</sup> (<a class="bibr" href="#ch2.appo.ref23" rid="ch2.appo.ref23">Fleming 2012</a>, <a class="bibr" href="#ch2.appo.ref60" rid="ch2.appo.ref60">Smith 2015</a>)</td><td headers="hd_h_ch2.apph.tab11_1_1_1_2 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab11_1_1_1_3 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">142</td><td headers="hd_h_ch2.apph.tab11_1_1_1_4 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>RR 0.21</p>
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<p>(0.01, 4.22)</p>
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</td><td headers="hd_h_ch2.apph.tab11_1_1_1_5 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab11_1_1_1_6 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 per 100</td><td headers="hd_h_ch2.apph.tab11_1_1_1_7 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>1 per 100</p>
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<p>(0, 12)</p>
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|
</td><td headers="hd_h_ch2.apph.tab11_1_1_1_8 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab11_1_1_1_9 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab11_1_1_1_10 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab11_1_1_1_11 hd_b_ch2.apph.tab11_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab11_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab11_2"><p class="no_margin">One study had no events in either arm and so only one study contributed to the analysis</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab11_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab11_4"><p class="no_margin">I<sup>2</sup> is greater than 33.3%</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab11_5"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab12"><div id="ch2.apph.tab12" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab12/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab12_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab12_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab12_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab12_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab12_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab12_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab12_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab12_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab12_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab12_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab12_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_h_ch2.apph.tab12_1_1_1_2 hd_h_ch2.apph.tab12_1_1_1_3 hd_h_ch2.apph.tab12_1_1_1_4 hd_h_ch2.apph.tab12_1_1_1_5 hd_h_ch2.apph.tab12_1_1_1_6 hd_h_ch2.apph.tab12_1_1_1_7 hd_h_ch2.apph.tab12_1_1_1_8 hd_h_ch2.apph.tab12_1_1_1_9 hd_h_ch2.apph.tab12_1_1_1_10 hd_h_ch2.apph.tab12_1_1_1_11" id="hd_b_ch2.apph.tab12_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS (values lower than 0 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref47" rid="ch2.appo.ref47">Merry 2012</a>)</td><td headers="hd_h_ch2.apph.tab12_1_1_1_2 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab12_1_1_1_3 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">187</td><td headers="hd_h_ch2.apph.tab12_1_1_1_4 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.16</p>
|
|
<p>(−0.45, 0.12)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_5 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.39</p>
|
|
<p>(−3.9, 1.04)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_6 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_7 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_8 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_9 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_10 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab12_1_1_1_11 hd_b_ch2.apph.tab12_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_h_ch2.apph.tab12_1_1_1_2 hd_h_ch2.apph.tab12_1_1_1_3 hd_h_ch2.apph.tab12_1_1_1_4 hd_h_ch2.apph.tab12_1_1_1_5 hd_h_ch2.apph.tab12_1_1_1_6 hd_h_ch2.apph.tab12_1_1_1_7 hd_h_ch2.apph.tab12_1_1_1_8 hd_h_ch2.apph.tab12_1_1_1_9 hd_h_ch2.apph.tab12_1_1_1_10 hd_h_ch2.apph.tab12_1_1_1_11" id="hd_b_ch2.apph.tab12_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS (values lower than 0 favour computer CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref47" rid="ch2.appo.ref47">Merry 2012</a>)</td><td headers="hd_h_ch2.apph.tab12_1_1_1_2 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab12_1_1_1_3 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">187</td><td headers="hd_h_ch2.apph.tab12_1_1_1_4 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.13</p>
|
|
<p>(−0.42, 0.16)</p>
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|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_5 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.13</p>
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|
<p>(−3.64, 1.39)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_6 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_7 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_8 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_9 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_10 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab12_1_1_1_11 hd_b_ch2.apph.tab12_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_h_ch2.apph.tab12_1_1_1_2 hd_h_ch2.apph.tab12_1_1_1_3 hd_h_ch2.apph.tab12_1_1_1_4 hd_h_ch2.apph.tab12_1_1_1_5 hd_h_ch2.apph.tab12_1_1_1_6 hd_h_ch2.apph.tab12_1_1_1_7 hd_h_ch2.apph.tab12_1_1_1_8 hd_h_ch2.apph.tab12_1_1_1_9 hd_h_ch2.apph.tab12_1_1_1_10 hd_h_ch2.apph.tab12_1_1_1_11" id="hd_b_ch2.apph.tab12_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, PQ-LES-Q (values lower than 0 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref47" rid="ch2.appo.ref47">Merry 2012</a>)</td><td headers="hd_h_ch2.apph.tab12_1_1_1_2 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab12_1_1_1_3 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">187</td><td headers="hd_h_ch2.apph.tab12_1_1_1_4 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.23</p>
|
|
<p>(−0.51, 0.06)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_5 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>***</sup>HoNOSCA scale</p>
|
|
<p>−1.49</p>
|
|
<p>(−3.3, 0.39)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_6 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_7 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_8 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_9 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_10 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab12_1_1_1_11 hd_b_ch2.apph.tab12_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_h_ch2.apph.tab12_1_1_1_2 hd_h_ch2.apph.tab12_1_1_1_3 hd_h_ch2.apph.tab12_1_1_1_4 hd_h_ch2.apph.tab12_1_1_1_5 hd_h_ch2.apph.tab12_1_1_1_6 hd_h_ch2.apph.tab12_1_1_1_7 hd_h_ch2.apph.tab12_1_1_1_8 hd_h_ch2.apph.tab12_1_1_1_9 hd_h_ch2.apph.tab12_1_1_1_10 hd_h_ch2.apph.tab12_1_1_1_11" id="hd_b_ch2.apph.tab12_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, PQ-LES-Q (values lower than 0 favour computer CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref47" rid="ch2.appo.ref47">Merry 2012</a>)</td><td headers="hd_h_ch2.apph.tab12_1_1_1_2 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab12_1_1_1_3 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">187</td><td headers="hd_h_ch2.apph.tab12_1_1_1_4 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.01</p>
|
|
<p>(−0.29, 0.28)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_5 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>***</sup>HoNOSCA scale</p>
|
|
<p>−0.06</p>
|
|
<p>(−1.88, 1.81)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_6 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_7 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_8 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_9 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_10 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab12_1_1_1_11 hd_b_ch2.apph.tab12_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_h_ch2.apph.tab12_1_1_1_2 hd_h_ch2.apph.tab12_1_1_1_3 hd_h_ch2.apph.tab12_1_1_1_4 hd_h_ch2.apph.tab12_1_1_1_5 hd_h_ch2.apph.tab12_1_1_1_6 hd_h_ch2.apph.tab12_1_1_1_7 hd_h_ch2.apph.tab12_1_1_1_8 hd_h_ch2.apph.tab12_1_1_1_9 hd_h_ch2.apph.tab12_1_1_1_10 hd_h_ch2.apph.tab12_1_1_1_11" id="hd_b_ch2.apph.tab12_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide-related adverse events – suicide attempt (values lower than 1 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref47" rid="ch2.appo.ref47">Merry 2012</a>)</td><td headers="hd_h_ch2.apph.tab12_1_1_1_2 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab12_1_1_1_3 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">187</td><td headers="hd_h_ch2.apph.tab12_1_1_1_4 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.98</p>
|
|
<p>(0.18, 21.45)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_5 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_6 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 per 100</td><td headers="hd_h_ch2.apph.tab12_1_1_1_7 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2 per 100</p>
|
|
<p>(0, 23)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_8 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_9 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_10 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab12_1_1_1_11 hd_b_ch2.apph.tab12_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_h_ch2.apph.tab12_1_1_1_2 hd_h_ch2.apph.tab12_1_1_1_3 hd_h_ch2.apph.tab12_1_1_1_4 hd_h_ch2.apph.tab12_1_1_1_5 hd_h_ch2.apph.tab12_1_1_1_6 hd_h_ch2.apph.tab12_1_1_1_7 hd_h_ch2.apph.tab12_1_1_1_8 hd_h_ch2.apph.tab12_1_1_1_9 hd_h_ch2.apph.tab12_1_1_1_10 hd_h_ch2.apph.tab12_1_1_1_11" id="hd_b_ch2.apph.tab12_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab12_1_1_1_1 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref47" rid="ch2.appo.ref47">Merry 2012</a>)</td><td headers="hd_h_ch2.apph.tab12_1_1_1_2 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab12_1_1_1_3 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">185</td><td headers="hd_h_ch2.apph.tab12_1_1_1_4 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.14</p>
|
|
<p>(0.46, 2.82)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_5 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab12_1_1_1_6 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 per 100</td><td headers="hd_h_ch2.apph.tab12_1_1_1_7 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>10 per 100</p>
|
|
<p>(4, 24)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab12_1_1_1_8 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_9 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab12_1_1_1_10 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab12_1_1_1_11 hd_b_ch2.apph.tab12_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab12_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>***</dt><dd><div id="ch2.apph.tab12_2"><p class="no_margin">SMD to MD conversion on HoNOSCA scale using pooled SD for all studies using this scale (6.4787)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab12_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab13"><div id="ch2.apph.tab13" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab13/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab13_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab13_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab13_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab13_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab13_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab13_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group CBT + computer CBT</th><th id="hd_h_ch2.apph.tab13_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: computer CBT (95% CI)</th><th id="hd_h_ch2.apph.tab13_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab13_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab13_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab13_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_h_ch2.apph.tab13_1_1_1_2 hd_h_ch2.apph.tab13_1_1_1_3 hd_h_ch2.apph.tab13_1_1_1_4 hd_h_ch2.apph.tab13_1_1_1_5 hd_h_ch2.apph.tab13_1_1_1_6 hd_h_ch2.apph.tab13_1_1_1_7 hd_h_ch2.apph.tab13_1_1_1_8 hd_h_ch2.apph.tab13_1_1_1_9 hd_h_ch2.apph.tab13_1_1_1_10 hd_h_ch2.apph.tab13_1_1_1_11" id="hd_b_ch2.apph.tab13_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab13_1_1_1_2 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab13_1_1_1_3 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch2.apph.tab13_1_1_1_4 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.09</p>
|
|
<p>(−0.47, 0.29)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_5 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.78</p>
|
|
<p>(−4.07, 2.51)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_6 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab13_1_1_1_7 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab13_1_1_1_8 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_9 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_10 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab13_1_1_1_11 hd_b_ch2.apph.tab13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_h_ch2.apph.tab13_1_1_1_2 hd_h_ch2.apph.tab13_1_1_1_3 hd_h_ch2.apph.tab13_1_1_1_4 hd_h_ch2.apph.tab13_1_1_1_5 hd_h_ch2.apph.tab13_1_1_1_6 hd_h_ch2.apph.tab13_1_1_1_7 hd_h_ch2.apph.tab13_1_1_1_8 hd_h_ch2.apph.tab13_1_1_1_9 hd_h_ch2.apph.tab13_1_1_1_10 hd_h_ch2.apph.tab13_1_1_1_11" id="hd_b_ch2.apph.tab13_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour computer CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab13_1_1_1_2 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab13_1_1_1_3 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch2.apph.tab13_1_1_1_4 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.06</p>
|
|
<p>(−0.44, 0.32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_5 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.52</p>
|
|
<p>(−3.81, 2.77)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_6 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab13_1_1_1_7 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab13_1_1_1_8 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_9 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_10 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab13_1_1_1_11 hd_b_ch2.apph.tab13_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_h_ch2.apph.tab13_1_1_1_2 hd_h_ch2.apph.tab13_1_1_1_3 hd_h_ch2.apph.tab13_1_1_1_4 hd_h_ch2.apph.tab13_1_1_1_5 hd_h_ch2.apph.tab13_1_1_1_6 hd_h_ch2.apph.tab13_1_1_1_7 hd_h_ch2.apph.tab13_1_1_1_8 hd_h_ch2.apph.tab13_1_1_1_9 hd_h_ch2.apph.tab13_1_1_1_10 hd_h_ch2.apph.tab13_1_1_1_11" id="hd_b_ch2.apph.tab13_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour computer CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab13_1_1_1_2 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab13_1_1_1_3 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch2.apph.tab13_1_1_1_4 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.35</p>
|
|
<p>(−0.73, 0.04)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_5 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.03</p>
|
|
<p>(−6.33, 0.35)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_6 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab13_1_1_1_7 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab13_1_1_1_8 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_9 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_10 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab13_1_1_1_11 hd_b_ch2.apph.tab13_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_h_ch2.apph.tab13_1_1_1_2 hd_h_ch2.apph.tab13_1_1_1_3 hd_h_ch2.apph.tab13_1_1_1_4 hd_h_ch2.apph.tab13_1_1_1_5 hd_h_ch2.apph.tab13_1_1_1_6 hd_h_ch2.apph.tab13_1_1_1_7 hd_h_ch2.apph.tab13_1_1_1_8 hd_h_ch2.apph.tab13_1_1_1_9 hd_h_ch2.apph.tab13_1_1_1_10 hd_h_ch2.apph.tab13_1_1_1_11" id="hd_b_ch2.apph.tab13_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, CDI item 9 score 2 (values lower than 1 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab13_1_1_1_2 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab13_1_1_1_3 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch2.apph.tab13_1_1_1_4 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.37</p>
|
|
<p>(0.04, 3.41)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_5 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab13_1_1_1_6 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 per 100</td><td headers="hd_h_ch2.apph.tab13_1_1_1_7 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2 per 100</p>
|
|
<p>(0, 18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_8 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_9 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_10 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab13_1_1_1_11 hd_b_ch2.apph.tab13_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_h_ch2.apph.tab13_1_1_1_2 hd_h_ch2.apph.tab13_1_1_1_3 hd_h_ch2.apph.tab13_1_1_1_4 hd_h_ch2.apph.tab13_1_1_1_5 hd_h_ch2.apph.tab13_1_1_1_6 hd_h_ch2.apph.tab13_1_1_1_7 hd_h_ch2.apph.tab13_1_1_1_8 hd_h_ch2.apph.tab13_1_1_1_9 hd_h_ch2.apph.tab13_1_1_1_10 hd_h_ch2.apph.tab13_1_1_1_11" id="hd_b_ch2.apph.tab13_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab13_1_1_1_1 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab13_1_1_1_2 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab13_1_1_1_3 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">104</td><td headers="hd_h_ch2.apph.tab13_1_1_1_4 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.04</p>
|
|
<p>(0.27, 3.94)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_5 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab13_1_1_1_6 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8 per 100</td><td headers="hd_h_ch2.apph.tab13_1_1_1_7 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>8 per 100</p>
|
|
<p>(2, 30)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab13_1_1_1_8 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_9 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab13_1_1_1_10 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab13_1_1_1_11 hd_b_ch2.apph.tab13_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab13_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab13_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab14"><div id="ch2.apph.tab14" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab14/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab14_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab14_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab14_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab14_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab14_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab14_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab14_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab14_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab14_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab14_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_h_ch2.apph.tab14_1_1_1_2 hd_h_ch2.apph.tab14_1_1_1_3 hd_h_ch2.apph.tab14_1_1_1_4 hd_h_ch2.apph.tab14_1_1_1_5 hd_h_ch2.apph.tab14_1_1_1_6 hd_h_ch2.apph.tab14_1_1_1_7 hd_h_ch2.apph.tab14_1_1_1_8 hd_h_ch2.apph.tab14_1_1_1_9 hd_h_ch2.apph.tab14_1_1_1_10 hd_h_ch2.apph.tab14_1_1_1_11" id="hd_b_ch2.apph.tab14_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref19" rid="ch2.appo.ref19">Dobson 2010</a>, <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab14_1_1_1_2 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab14_1_1_1_3 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">818</td><td headers="hd_h_ch2.apph.tab14_1_1_1_4 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.02</p>
|
|
<p>(−0.11, 0.16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_5 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>0.17</p>
|
|
<p>(−0.95, 1.39)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_6 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_7 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_8 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_9 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_10 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_11 hd_b_ch2.apph.tab14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_h_ch2.apph.tab14_1_1_1_2 hd_h_ch2.apph.tab14_1_1_1_3 hd_h_ch2.apph.tab14_1_1_1_4 hd_h_ch2.apph.tab14_1_1_1_5 hd_h_ch2.apph.tab14_1_1_1_6 hd_h_ch2.apph.tab14_1_1_1_7 hd_h_ch2.apph.tab14_1_1_1_8 hd_h_ch2.apph.tab14_1_1_1_9 hd_h_ch2.apph.tab14_1_1_1_10 hd_h_ch2.apph.tab14_1_1_1_11" id="hd_b_ch2.apph.tab14_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref19" rid="ch2.appo.ref19">Dobson 2010</a>, <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab14_1_1_1_2 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab14_1_1_1_3 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">733</td><td headers="hd_h_ch2.apph.tab14_1_1_1_4 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.02</p>
|
|
<p>(−0.12, 0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_5 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>0.17</p>
|
|
<p>(−1.04, 1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_6 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_7 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_8 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_9 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_10 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_11 hd_b_ch2.apph.tab14_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_h_ch2.apph.tab14_1_1_1_2 hd_h_ch2.apph.tab14_1_1_1_3 hd_h_ch2.apph.tab14_1_1_1_4 hd_h_ch2.apph.tab14_1_1_1_5 hd_h_ch2.apph.tab14_1_1_1_6 hd_h_ch2.apph.tab14_1_1_1_7 hd_h_ch2.apph.tab14_1_1_1_8 hd_h_ch2.apph.tab14_1_1_1_9 hd_h_ch2.apph.tab14_1_1_1_10 hd_h_ch2.apph.tab14_1_1_1_11" id="hd_b_ch2.apph.tab14_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab14_1_1_1_2 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab14_1_1_1_3 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101</td><td headers="hd_h_ch2.apph.tab14_1_1_1_4 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.19</p>
|
|
<p>(−0.20, 0.58)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_5 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>1.65</p>
|
|
<p>(−1.73, 5.03)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_6 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_7 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_8 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_9 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_10 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_11 hd_b_ch2.apph.tab14_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_h_ch2.apph.tab14_1_1_1_2 hd_h_ch2.apph.tab14_1_1_1_3 hd_h_ch2.apph.tab14_1_1_1_4 hd_h_ch2.apph.tab14_1_1_1_5 hd_h_ch2.apph.tab14_1_1_1_6 hd_h_ch2.apph.tab14_1_1_1_7 hd_h_ch2.apph.tab14_1_1_1_8 hd_h_ch2.apph.tab14_1_1_1_9 hd_h_ch2.apph.tab14_1_1_1_10 hd_h_ch2.apph.tab14_1_1_1_11" id="hd_b_ch2.apph.tab14_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, CDI item 9 score 2 (values lower than 1 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab14_1_1_1_2 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab14_1_1_1_3 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101</td><td headers="hd_h_ch2.apph.tab14_1_1_1_4 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.02</p>
|
|
<p>(0.07, 15.86)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_5 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_6 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 per 100</td><td headers="hd_h_ch2.apph.tab14_1_1_1_7 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2 per 100</p>
|
|
<p>(0, 31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_8 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_9 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_10 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_11 hd_b_ch2.apph.tab14_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_h_ch2.apph.tab14_1_1_1_2 hd_h_ch2.apph.tab14_1_1_1_3 hd_h_ch2.apph.tab14_1_1_1_4 hd_h_ch2.apph.tab14_1_1_1_5 hd_h_ch2.apph.tab14_1_1_1_6 hd_h_ch2.apph.tab14_1_1_1_7 hd_h_ch2.apph.tab14_1_1_1_8 hd_h_ch2.apph.tab14_1_1_1_9 hd_h_ch2.apph.tab14_1_1_1_10 hd_h_ch2.apph.tab14_1_1_1_11" id="hd_b_ch2.apph.tab14_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Self-harm, thoughts yes/no (values lower than 1 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab14_1_1_1_2 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab14_1_1_1_3 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">249</td><td headers="hd_h_ch2.apph.tab14_1_1_1_4 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.93</p>
|
|
<p>(0.76, 1.14)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_5 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_6 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34 per 100</td><td headers="hd_h_ch2.apph.tab14_1_1_1_7 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>31 per 100</p>
|
|
<p>(26, 38)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_8 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_9 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_10 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_11 hd_b_ch2.apph.tab14_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_h_ch2.apph.tab14_1_1_1_2 hd_h_ch2.apph.tab14_1_1_1_3 hd_h_ch2.apph.tab14_1_1_1_4 hd_h_ch2.apph.tab14_1_1_1_5 hd_h_ch2.apph.tab14_1_1_1_6 hd_h_ch2.apph.tab14_1_1_1_7 hd_h_ch2.apph.tab14_1_1_1_8 hd_h_ch2.apph.tab14_1_1_1_9 hd_h_ch2.apph.tab14_1_1_1_10 hd_h_ch2.apph.tab14_1_1_1_11" id="hd_b_ch2.apph.tab14_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Self-harm, deliberate yes/no (values lower than 1 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab14_1_1_1_2 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab14_1_1_1_3 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">148</td><td headers="hd_h_ch2.apph.tab14_1_1_1_4 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.03</p>
|
|
<p>(0.77, 1.38)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_5 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_6 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19 per 100</td><td headers="hd_h_ch2.apph.tab14_1_1_1_7 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>20 per 100</p>
|
|
<p>(15, 26)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_8 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_9 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_10 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_11 hd_b_ch2.apph.tab14_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_h_ch2.apph.tab14_1_1_1_2 hd_h_ch2.apph.tab14_1_1_1_3 hd_h_ch2.apph.tab14_1_1_1_4 hd_h_ch2.apph.tab14_1_1_1_5 hd_h_ch2.apph.tab14_1_1_1_6 hd_h_ch2.apph.tab14_1_1_1_7 hd_h_ch2.apph.tab14_1_1_1_8 hd_h_ch2.apph.tab14_1_1_1_9 hd_h_ch2.apph.tab14_1_1_1_10 hd_h_ch2.apph.tab14_1_1_1_11" id="hd_b_ch2.apph.tab14_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab14_1_1_1_1 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref19" rid="ch2.appo.ref19">Dobson 2010</a>, <a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>, <a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab14_1_1_1_2 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab14_1_1_1_3 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">182</td><td headers="hd_h_ch2.apph.tab14_1_1_1_4 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.41</p>
|
|
<p>(1.08, 1.83)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_5 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab14_1_1_1_6 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 per 100</td><td headers="hd_h_ch2.apph.tab14_1_1_1_7 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>23 per 100</p>
|
|
<p>(18, 30)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab14_1_1_1_8 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab14_1_1_1_9 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_10 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab14_1_1_1_11 hd_b_ch2.apph.tab14_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab14_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab14_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab14_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab15"><div id="ch2.apph.tab15" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab15/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab15_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab15_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab15_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab15_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab15_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab15_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab15_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab15_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab15_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab15_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab15_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab15_1_1_1_1 hd_h_ch2.apph.tab15_1_1_1_2 hd_h_ch2.apph.tab15_1_1_1_3 hd_h_ch2.apph.tab15_1_1_1_4 hd_h_ch2.apph.tab15_1_1_1_5 hd_h_ch2.apph.tab15_1_1_1_6 hd_h_ch2.apph.tab15_1_1_1_7 hd_h_ch2.apph.tab15_1_1_1_8 hd_h_ch2.apph.tab15_1_1_1_9 hd_h_ch2.apph.tab15_1_1_1_10 hd_h_ch2.apph.tab15_1_1_1_11" id="hd_b_ch2.apph.tab15_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab15_1_1_1_1 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 (<a class="bibr" href="#ch2.appo.ref50" rid="ch2.appo.ref50">Noel 2013</a>, <a class="bibr" href="#ch2.appo.ref54" rid="ch2.appo.ref54">Puskar 2003</a>, <a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>, <a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>, <a class="bibr" href="#ch2.appo.ref79" rid="ch2.appo.ref79">Wijnhoven 2014</a>)</td><td headers="hd_h_ch2.apph.tab15_1_1_1_2 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab15_1_1_1_3 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">395</td><td headers="hd_h_ch2.apph.tab15_1_1_1_4 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.68</p>
|
|
<p>(−0.89, −0.48)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab15_1_1_1_5 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−5.89</p>
|
|
<p>(−7.71, −4.16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab15_1_1_1_6 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab15_1_1_1_7 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab15_1_1_1_8 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab15_1_1_1_9 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab15_1_1_1_10 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab15_1_1_1_11 hd_b_ch2.apph.tab15_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab15_1_1_1_1 hd_h_ch2.apph.tab15_1_1_1_2 hd_h_ch2.apph.tab15_1_1_1_3 hd_h_ch2.apph.tab15_1_1_1_4 hd_h_ch2.apph.tab15_1_1_1_5 hd_h_ch2.apph.tab15_1_1_1_6 hd_h_ch2.apph.tab15_1_1_1_7 hd_h_ch2.apph.tab15_1_1_1_8 hd_h_ch2.apph.tab15_1_1_1_9 hd_h_ch2.apph.tab15_1_1_1_10 hd_h_ch2.apph.tab15_1_1_1_11" id="hd_b_ch2.apph.tab15_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab15_1_1_1_1 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>, <a class="bibr" href="#ch2.appo.ref54" rid="ch2.appo.ref54">Puskar 2003</a>, <a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>, <a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>, <a class="bibr" href="#ch2.appo.ref79" rid="ch2.appo.ref79">Wijnhoven 2014</a>)</td><td headers="hd_h_ch2.apph.tab15_1_1_1_2 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab15_1_1_1_3 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">394</td><td headers="hd_h_ch2.apph.tab15_1_1_1_4 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.53</p>
|
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<p>(−0.73, −0.33)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab15_1_1_1_5 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−4.59</p>
|
|
<p>(−6.33, −2.86)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab15_1_1_1_6 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab15_1_1_1_7 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab15_1_1_1_8 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab15_1_1_1_9 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab15_1_1_1_10 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab15_1_1_1_11 hd_b_ch2.apph.tab15_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab15_1_1_1_1 hd_h_ch2.apph.tab15_1_1_1_2 hd_h_ch2.apph.tab15_1_1_1_3 hd_h_ch2.apph.tab15_1_1_1_4 hd_h_ch2.apph.tab15_1_1_1_5 hd_h_ch2.apph.tab15_1_1_1_6 hd_h_ch2.apph.tab15_1_1_1_7 hd_h_ch2.apph.tab15_1_1_1_8 hd_h_ch2.apph.tab15_1_1_1_9 hd_h_ch2.apph.tab15_1_1_1_10 hd_h_ch2.apph.tab15_1_1_1_11" id="hd_b_ch2.apph.tab15_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab15_1_1_1_1 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref54" rid="ch2.appo.ref54">Puskar 2003</a>, <a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab15_1_1_1_2 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab15_1_1_1_3 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">144</td><td headers="hd_h_ch2.apph.tab15_1_1_1_4 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.21</p>
|
|
<p>(−0.46, 0.04)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab15_1_1_1_5 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.82</p>
|
|
<p>(−3.99, 0.35)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab15_1_1_1_6 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab15_1_1_1_7 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab15_1_1_1_8 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab15_1_1_1_9 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab15_1_1_1_10 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab15_1_1_1_11 hd_b_ch2.apph.tab15_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab15_1_1_1_1 hd_h_ch2.apph.tab15_1_1_1_2 hd_h_ch2.apph.tab15_1_1_1_3 hd_h_ch2.apph.tab15_1_1_1_4 hd_h_ch2.apph.tab15_1_1_1_5 hd_h_ch2.apph.tab15_1_1_1_6 hd_h_ch2.apph.tab15_1_1_1_7 hd_h_ch2.apph.tab15_1_1_1_8 hd_h_ch2.apph.tab15_1_1_1_9 hd_h_ch2.apph.tab15_1_1_1_10 hd_h_ch2.apph.tab15_1_1_1_11" id="hd_b_ch2.apph.tab15_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab15_1_1_1_1 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4 (<a class="bibr" href="#ch2.appo.ref54" rid="ch2.appo.ref54">Puskar 2003</a>, <a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>, <a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>, <a class="bibr" href="#ch2.appo.ref79" rid="ch2.appo.ref79">Wijnhoven 2014</a>)</td><td headers="hd_h_ch2.apph.tab15_1_1_1_2 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab15_1_1_1_3 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">381</td><td headers="hd_h_ch2.apph.tab15_1_1_1_4 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.15</p>
|
|
<p>(0.54, 2.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab15_1_1_1_5 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab15_1_1_1_6 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 per 100</td><td headers="hd_h_ch2.apph.tab15_1_1_1_7 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>18 per 100</p>
|
|
<p>(8, 38)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab15_1_1_1_8 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab15_1_1_1_9 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab15_1_1_1_10 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab15_1_1_1_11 hd_b_ch2.apph.tab15_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab15_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab15_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab15_3"><p class="no_margin">I<sup>2</sup> is greater than 33.3%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab16"><div id="ch2.apph.tab16" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab16/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab16_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab16_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab16_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab16_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab16_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab16_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab16_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab16_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab16_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab16_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab16_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status (values higher than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref10" rid="ch2.appo.ref10">Clarke, 1995</a>, <a class="bibr" href="#ch2.appo.ref12" rid="ch2.appo.ref12">Clarke 2001</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">204</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.27</p>
|
|
<p>(−0.00, 0.55)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>2.56</p>
|
|
<p>(−0.03, 5.21)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, GAF (values higher than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref10" rid="ch2.appo.ref10">Clarke 1995</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">112</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.01</p>
|
|
<p>(−0.38, 0.36)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>−0.09</p>
|
|
<p>(−3.6, 3.41)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A</td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status (values higher than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref10" rid="ch2.appo.ref10">Clarke, 1995</a>, <a class="bibr" href="#ch2.appo.ref12" rid="ch2.appo.ref12">Clarke 2001</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">182</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.27</p>
|
|
<p>(−0.02, 0.57)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>2.56</p>
|
|
<p>(−0.19, 5.4)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref10" rid="ch2.appo.ref10">Clarke 1995</a>, <a class="bibr" href="#ch2.appo.ref12" rid="ch2.appo.ref12">Clarke 2001</a>, <a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">798</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.03</p>
|
|
<p>(−0.17, 0.11)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.26</p>
|
|
<p>(−1.47, 0.95)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref10" rid="ch2.appo.ref10">Clarke 1995</a>, <a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">650</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.17</p>
|
|
<p>(0.01, 0.32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>1.47</p>
|
|
<p>(0.09, 2.77)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref10" rid="ch2.appo.ref10">Clarke, 1995</a>, <a class="bibr" href="#ch2.appo.ref12" rid="ch2.appo.ref12">Clarke 2001</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">182</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.20</p>
|
|
<p>(−0.49, 0.09)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.73</p>
|
|
<p>(−4.25, 0.78)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, K-SADS (values lower than 0 favour group CBT) – post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref12" rid="ch2.appo.ref12">Clarke 2001</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">84</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.23</p>
|
|
<p>(−0.60, 0.14)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_15_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, K-SADS (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref12" rid="ch2.appo.ref12">Clarke 2001</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.53</p>
|
|
<p>(−0.98, −0.08)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_17_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Self-harm, thoughts – yes/no (values lower than 1 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">213</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.04</p>
|
|
<p>(0.83, 1.30)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30 per 100</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>31 per 100</p>
|
|
<p>(25, 39)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_19_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Self-harm, deliberate – yes/no (values lower than 1 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">128</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.15</p>
|
|
<p>(0.83, 1.58)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17 per 100</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>20 per 100</p>
|
|
<p>(14, 27)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_h_ch2.apph.tab16_1_1_1_2 hd_h_ch2.apph.tab16_1_1_1_3 hd_h_ch2.apph.tab16_1_1_1_4 hd_h_ch2.apph.tab16_1_1_1_5 hd_h_ch2.apph.tab16_1_1_1_6 hd_h_ch2.apph.tab16_1_1_1_7 hd_h_ch2.apph.tab16_1_1_1_8 hd_h_ch2.apph.tab16_1_1_1_9 hd_h_ch2.apph.tab16_1_1_1_10 hd_h_ch2.apph.tab16_1_1_1_11" id="hd_b_ch2.apph.tab16_1_1_21_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab16_1_1_1_1 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref10" rid="ch2.appo.ref10">Clarke 1995</a>, <a class="bibr" href="#ch2.appo.ref61" rid="ch2.appo.ref61">Stallard 2012</a>)</td><td headers="hd_h_ch2.apph.tab16_1_1_1_2 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab16_1_1_1_3 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">840</td><td headers="hd_h_ch2.apph.tab16_1_1_1_4 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.36</p>
|
|
<p>(0.62, 9.06)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_5 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab16_1_1_1_6 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 per 100</td><td headers="hd_h_ch2.apph.tab16_1_1_1_7 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>38 per 100</p>
|
|
<p>(10, 146)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab16_1_1_1_8 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_9 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab16_1_1_1_10 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>4</sup></td><td headers="hd_h_ch2.apph.tab16_1_1_1_11 hd_b_ch2.apph.tab16_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab16_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab16_2"><p class="no_margin">SMD to MD conversion on CGAS scale using pooled SD for all studies using this scale (9.47517)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab16_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab16_4"><p class="no_margin">I<sup>2</sup> is greater than 33.3%</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab16_5"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch2.apph.tab16_6"><p class="no_margin">I<sup>2</sup> is greater than 66.7%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab17"><div id="ch2.apph.tab17" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab17/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab17_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab17_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab17_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab17_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab17_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab17_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: guided self-help</th><th id="hd_h_ch2.apph.tab17_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group CBT (95% CI)</th><th id="hd_h_ch2.apph.tab17_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab17_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab17_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab17_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab17_1_1_1_1 hd_h_ch2.apph.tab17_1_1_1_2 hd_h_ch2.apph.tab17_1_1_1_3 hd_h_ch2.apph.tab17_1_1_1_4 hd_h_ch2.apph.tab17_1_1_1_5 hd_h_ch2.apph.tab17_1_1_1_6 hd_h_ch2.apph.tab17_1_1_1_7 hd_h_ch2.apph.tab17_1_1_1_8 hd_h_ch2.apph.tab17_1_1_1_9 hd_h_ch2.apph.tab17_1_1_1_10 hd_h_ch2.apph.tab17_1_1_1_11" id="hd_b_ch2.apph.tab17_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab17_1_1_1_1 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab17_1_1_1_2 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab17_1_1_1_3 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">169</td><td headers="hd_h_ch2.apph.tab17_1_1_1_4 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.58</p>
|
|
<p>(−0.89, −0.27)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab17_1_1_1_5 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−5.03</p>
|
|
<p>(−7.71, −2.34)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab17_1_1_1_6 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab17_1_1_1_7 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab17_1_1_1_8 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab17_1_1_1_9 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab17_1_1_1_10 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab17_1_1_1_11 hd_b_ch2.apph.tab17_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab17_1_1_1_1 hd_h_ch2.apph.tab17_1_1_1_2 hd_h_ch2.apph.tab17_1_1_1_3 hd_h_ch2.apph.tab17_1_1_1_4 hd_h_ch2.apph.tab17_1_1_1_5 hd_h_ch2.apph.tab17_1_1_1_6 hd_h_ch2.apph.tab17_1_1_1_7 hd_h_ch2.apph.tab17_1_1_1_8 hd_h_ch2.apph.tab17_1_1_1_9 hd_h_ch2.apph.tab17_1_1_1_10 hd_h_ch2.apph.tab17_1_1_1_11" id="hd_b_ch2.apph.tab17_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab17_1_1_1_1 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab17_1_1_1_2 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab17_1_1_1_3 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">169</td><td headers="hd_h_ch2.apph.tab17_1_1_1_4 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.55</p>
|
|
<p>(−0.86, −0.25)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab17_1_1_1_5 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−4.77</p>
|
|
<p>(−7.45, −2.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab17_1_1_1_6 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab17_1_1_1_7 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab17_1_1_1_8 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab17_1_1_1_9 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab17_1_1_1_10 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab17_1_1_1_11 hd_b_ch2.apph.tab17_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab17_1_1_1_1 hd_h_ch2.apph.tab17_1_1_1_2 hd_h_ch2.apph.tab17_1_1_1_3 hd_h_ch2.apph.tab17_1_1_1_4 hd_h_ch2.apph.tab17_1_1_1_5 hd_h_ch2.apph.tab17_1_1_1_6 hd_h_ch2.apph.tab17_1_1_1_7 hd_h_ch2.apph.tab17_1_1_1_8 hd_h_ch2.apph.tab17_1_1_1_9 hd_h_ch2.apph.tab17_1_1_1_10 hd_h_ch2.apph.tab17_1_1_1_11" id="hd_b_ch2.apph.tab17_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab17_1_1_1_1 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab17_1_1_1_2 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab17_1_1_1_3 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">169</td><td headers="hd_h_ch2.apph.tab17_1_1_1_4 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.12 (−0.42, 0.19)</p>
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</td><td headers="hd_h_ch2.apph.tab17_1_1_1_5 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−10 (−36.05, 15.77)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab17_1_1_1_6 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab17_1_1_1_7 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab17_1_1_1_8 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab17_1_1_1_9 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab17_1_1_1_10 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab17_1_1_1_11 hd_b_ch2.apph.tab17_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab17_1_1_1_1 hd_h_ch2.apph.tab17_1_1_1_2 hd_h_ch2.apph.tab17_1_1_1_3 hd_h_ch2.apph.tab17_1_1_1_4 hd_h_ch2.apph.tab17_1_1_1_5 hd_h_ch2.apph.tab17_1_1_1_6 hd_h_ch2.apph.tab17_1_1_1_7 hd_h_ch2.apph.tab17_1_1_1_8 hd_h_ch2.apph.tab17_1_1_1_9 hd_h_ch2.apph.tab17_1_1_1_10 hd_h_ch2.apph.tab17_1_1_1_11" id="hd_b_ch2.apph.tab17_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab17_1_1_1_1 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab17_1_1_1_2 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab17_1_1_1_3 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41</td><td headers="hd_h_ch2.apph.tab17_1_1_1_4 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.86</p>
|
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<p>(0.51, 1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab17_1_1_1_5 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab17_1_1_1_6 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28 per 100</td><td headers="hd_h_ch2.apph.tab17_1_1_1_7 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>24 per 100</p>
|
|
<p>(14, 40)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab17_1_1_1_8 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab17_1_1_1_9 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab17_1_1_1_10 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab17_1_1_1_11 hd_b_ch2.apph.tab17_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab17_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab17_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab17_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab18"><div id="ch2.apph.tab18" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab18/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab18_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab18_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab18_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab18_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab18_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab18_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group NDST</th><th id="hd_h_ch2.apph.tab18_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group CBT (95% CI)</th><th id="hd_h_ch2.apph.tab18_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab18_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab18_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab18_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab18_1_1_1_1 hd_h_ch2.apph.tab18_1_1_1_2 hd_h_ch2.apph.tab18_1_1_1_3 hd_h_ch2.apph.tab18_1_1_1_4 hd_h_ch2.apph.tab18_1_1_1_5 hd_h_ch2.apph.tab18_1_1_1_6 hd_h_ch2.apph.tab18_1_1_1_7 hd_h_ch2.apph.tab18_1_1_1_8 hd_h_ch2.apph.tab18_1_1_1_9 hd_h_ch2.apph.tab18_1_1_1_10 hd_h_ch2.apph.tab18_1_1_1_11" id="hd_b_ch2.apph.tab18_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab18_1_1_1_1 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab18_1_1_1_2 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab18_1_1_1_3 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">177</td><td headers="hd_h_ch2.apph.tab18_1_1_1_4 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.36</p>
|
|
<p>(−0.66, −0.07)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab18_1_1_1_5 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.12</p>
|
|
<p>(−5.72, −0.61)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab18_1_1_1_6 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab18_1_1_1_7 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab18_1_1_1_8 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab18_1_1_1_9 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab18_1_1_1_10 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab18_1_1_1_11 hd_b_ch2.apph.tab18_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab18_1_1_1_1 hd_h_ch2.apph.tab18_1_1_1_2 hd_h_ch2.apph.tab18_1_1_1_3 hd_h_ch2.apph.tab18_1_1_1_4 hd_h_ch2.apph.tab18_1_1_1_5 hd_h_ch2.apph.tab18_1_1_1_6 hd_h_ch2.apph.tab18_1_1_1_7 hd_h_ch2.apph.tab18_1_1_1_8 hd_h_ch2.apph.tab18_1_1_1_9 hd_h_ch2.apph.tab18_1_1_1_10 hd_h_ch2.apph.tab18_1_1_1_11" id="hd_b_ch2.apph.tab18_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab18_1_1_1_1 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab18_1_1_1_2 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab18_1_1_1_3 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">177</td><td headers="hd_h_ch2.apph.tab18_1_1_1_4 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.07</p>
|
|
<p>(−0.36, 0.23)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab18_1_1_1_5 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.61</p>
|
|
<p>(−3.12, 1.99)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab18_1_1_1_6 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab18_1_1_1_7 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab18_1_1_1_8 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab18_1_1_1_9 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab18_1_1_1_10 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab18_1_1_1_11 hd_b_ch2.apph.tab18_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab18_1_1_1_1 hd_h_ch2.apph.tab18_1_1_1_2 hd_h_ch2.apph.tab18_1_1_1_3 hd_h_ch2.apph.tab18_1_1_1_4 hd_h_ch2.apph.tab18_1_1_1_5 hd_h_ch2.apph.tab18_1_1_1_6 hd_h_ch2.apph.tab18_1_1_1_7 hd_h_ch2.apph.tab18_1_1_1_8 hd_h_ch2.apph.tab18_1_1_1_9 hd_h_ch2.apph.tab18_1_1_1_10 hd_h_ch2.apph.tab18_1_1_1_11" id="hd_b_ch2.apph.tab18_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab18_1_1_1_1 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab18_1_1_1_2 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab18_1_1_1_3 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">177</td><td headers="hd_h_ch2.apph.tab18_1_1_1_4 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.14</p>
|
|
<p>(−0.15, 0.44)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab18_1_1_1_5 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>1.21</p>
|
|
<p>(−1.3, 3.81)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab18_1_1_1_6 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab18_1_1_1_7 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab18_1_1_1_8 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab18_1_1_1_9 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab18_1_1_1_10 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab18_1_1_1_11 hd_b_ch2.apph.tab18_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab18_1_1_1_1 hd_h_ch2.apph.tab18_1_1_1_2 hd_h_ch2.apph.tab18_1_1_1_3 hd_h_ch2.apph.tab18_1_1_1_4 hd_h_ch2.apph.tab18_1_1_1_5 hd_h_ch2.apph.tab18_1_1_1_6 hd_h_ch2.apph.tab18_1_1_1_7 hd_h_ch2.apph.tab18_1_1_1_8 hd_h_ch2.apph.tab18_1_1_1_9 hd_h_ch2.apph.tab18_1_1_1_10 hd_h_ch2.apph.tab18_1_1_1_11" id="hd_b_ch2.apph.tab18_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab18_1_1_1_1 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab18_1_1_1_2 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab18_1_1_1_3 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">155</td><td headers="hd_h_ch2.apph.tab18_1_1_1_4 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.77</p>
|
|
<p>(0.46, 1.30)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab18_1_1_1_5 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab18_1_1_1_6 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31 per 100</td><td headers="hd_h_ch2.apph.tab18_1_1_1_7 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>24 per 100</p>
|
|
<p>(14, 40)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab18_1_1_1_8 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab18_1_1_1_9 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab18_1_1_1_10 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab18_1_1_1_11 hd_b_ch2.apph.tab18_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab18_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab18_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab18_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab19"><div id="ch2.apph.tab19" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab19/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab19_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab19_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab19_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab19_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab19_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab19_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: relaxation</th><th id="hd_h_ch2.apph.tab19_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group CBT (95% CI)</th><th id="hd_h_ch2.apph.tab19_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab19_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab19_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab19_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab19_1_1_1_1 hd_h_ch2.apph.tab19_1_1_1_2 hd_h_ch2.apph.tab19_1_1_1_3 hd_h_ch2.apph.tab19_1_1_1_4 hd_h_ch2.apph.tab19_1_1_1_5 hd_h_ch2.apph.tab19_1_1_1_6 hd_h_ch2.apph.tab19_1_1_1_7 hd_h_ch2.apph.tab19_1_1_1_8 hd_h_ch2.apph.tab19_1_1_1_9 hd_h_ch2.apph.tab19_1_1_1_10 hd_h_ch2.apph.tab19_1_1_1_11" id="hd_b_ch2.apph.tab19_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab19_1_1_1_1 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>, <a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>)</td><td headers="hd_h_ch2.apph.tab19_1_1_1_2 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab19_1_1_1_3 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47</td><td headers="hd_h_ch2.apph.tab19_1_1_1_4 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.20</p>
|
|
<p>(−0.78, 0.38)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab19_1_1_1_5 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.73</p>
|
|
<p>(−6.76, 3.29)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab19_1_1_1_6 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab19_1_1_1_7 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab19_1_1_1_8 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab19_1_1_1_9 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab19_1_1_1_10 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab19_1_1_1_11 hd_b_ch2.apph.tab19_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab19_1_1_1_1 hd_h_ch2.apph.tab19_1_1_1_2 hd_h_ch2.apph.tab19_1_1_1_3 hd_h_ch2.apph.tab19_1_1_1_4 hd_h_ch2.apph.tab19_1_1_1_5 hd_h_ch2.apph.tab19_1_1_1_6 hd_h_ch2.apph.tab19_1_1_1_7 hd_h_ch2.apph.tab19_1_1_1_8 hd_h_ch2.apph.tab19_1_1_1_9 hd_h_ch2.apph.tab19_1_1_1_10 hd_h_ch2.apph.tab19_1_1_1_11" id="hd_b_ch2.apph.tab19_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab19_1_1_1_1 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>, <a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>)</td><td headers="hd_h_ch2.apph.tab19_1_1_1_2 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab19_1_1_1_3 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45</td><td headers="hd_h_ch2.apph.tab19_1_1_1_4 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.39</p>
|
|
<p>(−0.98, 0.21)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab19_1_1_1_5 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.38</p>
|
|
<p>(−8.49, 1.82)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab19_1_1_1_6 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab19_1_1_1_7 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab19_1_1_1_8 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab19_1_1_1_9 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab19_1_1_1_10 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab19_1_1_1_11 hd_b_ch2.apph.tab19_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab19_1_1_1_1 hd_h_ch2.apph.tab19_1_1_1_2 hd_h_ch2.apph.tab19_1_1_1_3 hd_h_ch2.apph.tab19_1_1_1_4 hd_h_ch2.apph.tab19_1_1_1_5 hd_h_ch2.apph.tab19_1_1_1_6 hd_h_ch2.apph.tab19_1_1_1_7 hd_h_ch2.apph.tab19_1_1_1_8 hd_h_ch2.apph.tab19_1_1_1_9 hd_h_ch2.apph.tab19_1_1_1_10 hd_h_ch2.apph.tab19_1_1_1_11" id="hd_b_ch2.apph.tab19_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab19_1_1_1_1 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>)</td><td headers="hd_h_ch2.apph.tab19_1_1_1_2 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab19_1_1_1_3 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20</td><td headers="hd_h_ch2.apph.tab19_1_1_1_4 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.73</p>
|
|
<p>(0.24, 2.27)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab19_1_1_1_5 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab19_1_1_1_6 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45 per 100</td><td headers="hd_h_ch2.apph.tab19_1_1_1_7 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>33 per 100</p>
|
|
<p>(11, 103)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab19_1_1_1_8 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab19_1_1_1_9 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab19_1_1_1_10 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab19_1_1_1_11 hd_b_ch2.apph.tab19_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab19_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab19_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab19_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab20"><div id="ch2.apph.tab20" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab20/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab20_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab20_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab20_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab20_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab20_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab20_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: self-modelling</th><th id="hd_h_ch2.apph.tab20_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group CBT (95% CI)</th><th id="hd_h_ch2.apph.tab20_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab20_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab20_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab20_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab20_1_1_1_1 hd_h_ch2.apph.tab20_1_1_1_2 hd_h_ch2.apph.tab20_1_1_1_3 hd_h_ch2.apph.tab20_1_1_1_4 hd_h_ch2.apph.tab20_1_1_1_5 hd_h_ch2.apph.tab20_1_1_1_6 hd_h_ch2.apph.tab20_1_1_1_7 hd_h_ch2.apph.tab20_1_1_1_8 hd_h_ch2.apph.tab20_1_1_1_9 hd_h_ch2.apph.tab20_1_1_1_10 hd_h_ch2.apph.tab20_1_1_1_11" id="hd_b_ch2.apph.tab20_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab20_1_1_1_1 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>)</td><td headers="hd_h_ch2.apph.tab20_1_1_1_2 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab20_1_1_1_3 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_ch2.apph.tab20_1_1_1_4 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −6.06</p>
|
|
<p>(−35.64, 23.52)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab20_1_1_1_5 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab20_1_1_1_6 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab20_1_1_1_7 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab20_1_1_1_8 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab20_1_1_1_9 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab20_1_1_1_10 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab20_1_1_1_11 hd_b_ch2.apph.tab20_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab20_1_1_1_1 hd_h_ch2.apph.tab20_1_1_1_2 hd_h_ch2.apph.tab20_1_1_1_3 hd_h_ch2.apph.tab20_1_1_1_4 hd_h_ch2.apph.tab20_1_1_1_5 hd_h_ch2.apph.tab20_1_1_1_6 hd_h_ch2.apph.tab20_1_1_1_7 hd_h_ch2.apph.tab20_1_1_1_8 hd_h_ch2.apph.tab20_1_1_1_9 hd_h_ch2.apph.tab20_1_1_1_10 hd_h_ch2.apph.tab20_1_1_1_11" id="hd_b_ch2.apph.tab20_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab20_1_1_1_1 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>)</td><td headers="hd_h_ch2.apph.tab20_1_1_1_2 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab20_1_1_1_3 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_ch2.apph.tab20_1_1_1_4 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>MD −5.24</p>
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<p>(−12.57, 2.09)</p>
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|
</td><td headers="hd_h_ch2.apph.tab20_1_1_1_5 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab20_1_1_1_6 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab20_1_1_1_7 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab20_1_1_1_8 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab20_1_1_1_9 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab20_1_1_1_10 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab20_1_1_1_11 hd_b_ch2.apph.tab20_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab20_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab20_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab21"><div id="ch2.apph.tab21" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab21/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab21_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab21_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab21_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab21_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab21_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab21_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab21_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab21_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab21_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab21_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab21_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab21_1_1_1_1 hd_h_ch2.apph.tab21_1_1_1_2 hd_h_ch2.apph.tab21_1_1_1_3 hd_h_ch2.apph.tab21_1_1_1_4 hd_h_ch2.apph.tab21_1_1_1_5 hd_h_ch2.apph.tab21_1_1_1_6 hd_h_ch2.apph.tab21_1_1_1_7 hd_h_ch2.apph.tab21_1_1_1_8 hd_h_ch2.apph.tab21_1_1_1_9 hd_h_ch2.apph.tab21_1_1_1_10 hd_h_ch2.apph.tab21_1_1_1_11" id="hd_b_ch2.apph.tab21_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab21_1_1_1_1 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab21_1_1_1_2 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab21_1_1_1_3 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101</td><td headers="hd_h_ch2.apph.tab21_1_1_1_4 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD 0.34</p>
|
|
<p>(−0.06, 0.73)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab21_1_1_1_5 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
|
<p>2.95</p>
|
|
<p>(−0.52, 6.33)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab21_1_1_1_6 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab21_1_1_1_7 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab21_1_1_1_8 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab21_1_1_1_9 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab21_1_1_1_10 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab21_1_1_1_11 hd_b_ch2.apph.tab21_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab21_1_1_1_1 hd_h_ch2.apph.tab21_1_1_1_2 hd_h_ch2.apph.tab21_1_1_1_3 hd_h_ch2.apph.tab21_1_1_1_4 hd_h_ch2.apph.tab21_1_1_1_5 hd_h_ch2.apph.tab21_1_1_1_6 hd_h_ch2.apph.tab21_1_1_1_7 hd_h_ch2.apph.tab21_1_1_1_8 hd_h_ch2.apph.tab21_1_1_1_9 hd_h_ch2.apph.tab21_1_1_1_10 hd_h_ch2.apph.tab21_1_1_1_11" id="hd_b_ch2.apph.tab21_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab21_1_1_1_1 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab21_1_1_1_2 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab21_1_1_1_3 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101</td><td headers="hd_h_ch2.apph.tab21_1_1_1_4 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.28</p>
|
|
<p>(−0.11, 0.67)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab21_1_1_1_5 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>2.43</p>
|
|
<p>(−0.95, 5.81)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab21_1_1_1_6 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab21_1_1_1_7 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab21_1_1_1_8 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab21_1_1_1_9 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab21_1_1_1_10 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab21_1_1_1_11 hd_b_ch2.apph.tab21_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab21_1_1_1_1 hd_h_ch2.apph.tab21_1_1_1_2 hd_h_ch2.apph.tab21_1_1_1_3 hd_h_ch2.apph.tab21_1_1_1_4 hd_h_ch2.apph.tab21_1_1_1_5 hd_h_ch2.apph.tab21_1_1_1_6 hd_h_ch2.apph.tab21_1_1_1_7 hd_h_ch2.apph.tab21_1_1_1_8 hd_h_ch2.apph.tab21_1_1_1_9 hd_h_ch2.apph.tab21_1_1_1_10 hd_h_ch2.apph.tab21_1_1_1_11" id="hd_b_ch2.apph.tab21_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab21_1_1_1_1 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab21_1_1_1_2 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab21_1_1_1_3 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101</td><td headers="hd_h_ch2.apph.tab21_1_1_1_4 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.65</p>
|
|
<p>(0.25, 1.06)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab21_1_1_1_5 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>5.63</p>
|
|
<p>(2.17, 9.19)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab21_1_1_1_6 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab21_1_1_1_7 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab21_1_1_1_8 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab21_1_1_1_9 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab21_1_1_1_10 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab21_1_1_1_11 hd_b_ch2.apph.tab21_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab21_1_1_1_1 hd_h_ch2.apph.tab21_1_1_1_2 hd_h_ch2.apph.tab21_1_1_1_3 hd_h_ch2.apph.tab21_1_1_1_4 hd_h_ch2.apph.tab21_1_1_1_5 hd_h_ch2.apph.tab21_1_1_1_6 hd_h_ch2.apph.tab21_1_1_1_7 hd_h_ch2.apph.tab21_1_1_1_8 hd_h_ch2.apph.tab21_1_1_1_9 hd_h_ch2.apph.tab21_1_1_1_10 hd_h_ch2.apph.tab21_1_1_1_11" id="hd_b_ch2.apph.tab21_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, CDI item 9 score 2 (values lower than 1 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab21_1_1_1_1 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab21_1_1_1_2 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab21_1_1_1_3 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">101</td><td headers="hd_h_ch2.apph.tab21_1_1_1_4 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.34</p>
|
|
<p>(0.04, 3.16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab21_1_1_1_5 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab21_1_1_1_6 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6 per 100</td><td headers="hd_h_ch2.apph.tab21_1_1_1_7 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2 per 100</p>
|
|
<p>(0, 19)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab21_1_1_1_8 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab21_1_1_1_9 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab21_1_1_1_10 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab21_1_1_1_11 hd_b_ch2.apph.tab21_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab21_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab21_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab22"><div id="ch2.apph.tab22" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab22/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab22_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab22_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab22_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab22_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab22_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab22_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: computer CBT</th><th id="hd_h_ch2.apph.tab22_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: Group CBT (95% CI)</th><th id="hd_h_ch2.apph.tab22_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab22_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab22_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab22_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_h_ch2.apph.tab22_1_1_1_2 hd_h_ch2.apph.tab22_1_1_1_3 hd_h_ch2.apph.tab22_1_1_1_4 hd_h_ch2.apph.tab22_1_1_1_5 hd_h_ch2.apph.tab22_1_1_1_6 hd_h_ch2.apph.tab22_1_1_1_7 hd_h_ch2.apph.tab22_1_1_1_8 hd_h_ch2.apph.tab22_1_1_1_9 hd_h_ch2.apph.tab22_1_1_1_10 hd_h_ch2.apph.tab22_1_1_1_11" id="hd_b_ch2.apph.tab22_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab22_1_1_1_2 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab22_1_1_1_3 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">106</td><td headers="hd_h_ch2.apph.tab22_1_1_1_4 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD 0.20</p>
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<p>(−0.19, 0.58)</p>
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</td><td headers="hd_h_ch2.apph.tab22_1_1_1_5 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>1.73</p>
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<p>(−1.65, 5.03)</p>
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</td><td headers="hd_h_ch2.apph.tab22_1_1_1_6 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab22_1_1_1_7 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab22_1_1_1_8 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_9 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_10 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab22_1_1_1_11 hd_b_ch2.apph.tab22_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_h_ch2.apph.tab22_1_1_1_2 hd_h_ch2.apph.tab22_1_1_1_3 hd_h_ch2.apph.tab22_1_1_1_4 hd_h_ch2.apph.tab22_1_1_1_5 hd_h_ch2.apph.tab22_1_1_1_6 hd_h_ch2.apph.tab22_1_1_1_7 hd_h_ch2.apph.tab22_1_1_1_8 hd_h_ch2.apph.tab22_1_1_1_9 hd_h_ch2.apph.tab22_1_1_1_10 hd_h_ch2.apph.tab22_1_1_1_11" id="hd_b_ch2.apph.tab22_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab22_1_1_1_2 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab22_1_1_1_3 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">106</td><td headers="hd_h_ch2.apph.tab22_1_1_1_4 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD 0.18</p>
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<p>(−0.20, 0.56)</p>
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</td><td headers="hd_h_ch2.apph.tab22_1_1_1_5 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>1.56</p>
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<p>(−1.73, 4.85)</p>
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</td><td headers="hd_h_ch2.apph.tab22_1_1_1_6 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab22_1_1_1_7 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab22_1_1_1_8 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_9 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_10 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab22_1_1_1_11 hd_b_ch2.apph.tab22_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_h_ch2.apph.tab22_1_1_1_2 hd_h_ch2.apph.tab22_1_1_1_3 hd_h_ch2.apph.tab22_1_1_1_4 hd_h_ch2.apph.tab22_1_1_1_5 hd_h_ch2.apph.tab22_1_1_1_6 hd_h_ch2.apph.tab22_1_1_1_7 hd_h_ch2.apph.tab22_1_1_1_8 hd_h_ch2.apph.tab22_1_1_1_9 hd_h_ch2.apph.tab22_1_1_1_10 hd_h_ch2.apph.tab22_1_1_1_11" id="hd_b_ch2.apph.tab22_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab22_1_1_1_2 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab22_1_1_1_3 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">106</td><td headers="hd_h_ch2.apph.tab22_1_1_1_4 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD 0.21</p>
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<p>(−0.17, 0.59)</p>
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</td><td headers="hd_h_ch2.apph.tab22_1_1_1_5 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
|
|
<p>1.82</p>
|
|
<p>(−1.47, 5.11)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab22_1_1_1_6 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab22_1_1_1_7 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab22_1_1_1_8 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_9 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_10 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab22_1_1_1_11 hd_b_ch2.apph.tab22_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_h_ch2.apph.tab22_1_1_1_2 hd_h_ch2.apph.tab22_1_1_1_3 hd_h_ch2.apph.tab22_1_1_1_4 hd_h_ch2.apph.tab22_1_1_1_5 hd_h_ch2.apph.tab22_1_1_1_6 hd_h_ch2.apph.tab22_1_1_1_7 hd_h_ch2.apph.tab22_1_1_1_8 hd_h_ch2.apph.tab22_1_1_1_9 hd_h_ch2.apph.tab22_1_1_1_10 hd_h_ch2.apph.tab22_1_1_1_11" id="hd_b_ch2.apph.tab22_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, CDI item 9 score 2 (values lower than 1 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab22_1_1_1_2 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab22_1_1_1_3 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">106</td><td headers="hd_h_ch2.apph.tab22_1_1_1_4 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.12</p>
|
|
<p>(0.07, 17.44)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab22_1_1_1_5 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab22_1_1_1_6 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 per 100</td><td headers="hd_h_ch2.apph.tab22_1_1_1_7 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2 per 100</p>
|
|
<p>(0, 31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab22_1_1_1_8 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_9 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_10 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab22_1_1_1_11 hd_b_ch2.apph.tab22_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_h_ch2.apph.tab22_1_1_1_2 hd_h_ch2.apph.tab22_1_1_1_3 hd_h_ch2.apph.tab22_1_1_1_4 hd_h_ch2.apph.tab22_1_1_1_5 hd_h_ch2.apph.tab22_1_1_1_6 hd_h_ch2.apph.tab22_1_1_1_7 hd_h_ch2.apph.tab22_1_1_1_8 hd_h_ch2.apph.tab22_1_1_1_9 hd_h_ch2.apph.tab22_1_1_1_10 hd_h_ch2.apph.tab22_1_1_1_11" id="hd_b_ch2.apph.tab22_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab22_1_1_1_1 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab22_1_1_1_2 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab22_1_1_1_3 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">100</td><td headers="hd_h_ch2.apph.tab22_1_1_1_4 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.56</p>
|
|
<p>(0.11, 2.94)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab22_1_1_1_5 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab22_1_1_1_6 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8 per 100</td><td headers="hd_h_ch2.apph.tab22_1_1_1_7 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>4 per 100</p>
|
|
<p>(1, 22)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab22_1_1_1_8 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_9 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab22_1_1_1_10 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab22_1_1_1_11 hd_b_ch2.apph.tab22_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab22_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab22_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab23"><div id="ch2.apph.tab23" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab23/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab23_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab23_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab23_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab23_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab23_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab23_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group mindfulness</th><th id="hd_h_ch2.apph.tab23_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group CBT (95% CI)</th><th id="hd_h_ch2.apph.tab23_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab23_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab23_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab23_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab23_1_1_1_1 hd_h_ch2.apph.tab23_1_1_1_2 hd_h_ch2.apph.tab23_1_1_1_3 hd_h_ch2.apph.tab23_1_1_1_4 hd_h_ch2.apph.tab23_1_1_1_5 hd_h_ch2.apph.tab23_1_1_1_6 hd_h_ch2.apph.tab23_1_1_1_7 hd_h_ch2.apph.tab23_1_1_1_8 hd_h_ch2.apph.tab23_1_1_1_9 hd_h_ch2.apph.tab23_1_1_1_10 hd_h_ch2.apph.tab23_1_1_1_11" id="hd_b_ch2.apph.tab23_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CES-D (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab23_1_1_1_1 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>)</td><td headers="hd_h_ch2.apph.tab23_1_1_1_2 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab23_1_1_1_3 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_ch2.apph.tab23_1_1_1_4 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD 0.80</p>
|
|
<p>(0.09, 1.51)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab23_1_1_1_5 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
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<p>6.93</p>
|
|
<p>(0.78, 13.09)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab23_1_1_1_6 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab23_1_1_1_7 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab23_1_1_1_8 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_9 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_10 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_11 hd_b_ch2.apph.tab23_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab23_1_1_1_1 hd_h_ch2.apph.tab23_1_1_1_2 hd_h_ch2.apph.tab23_1_1_1_3 hd_h_ch2.apph.tab23_1_1_1_4 hd_h_ch2.apph.tab23_1_1_1_5 hd_h_ch2.apph.tab23_1_1_1_6 hd_h_ch2.apph.tab23_1_1_1_7 hd_h_ch2.apph.tab23_1_1_1_8 hd_h_ch2.apph.tab23_1_1_1_9 hd_h_ch2.apph.tab23_1_1_1_10 hd_h_ch2.apph.tab23_1_1_1_11" id="hd_b_ch2.apph.tab23_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CES-D (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab23_1_1_1_1 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>)</td><td headers="hd_h_ch2.apph.tab23_1_1_1_2 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab23_1_1_1_3 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_ch2.apph.tab23_1_1_1_4 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.80</p>
|
|
<p>(0.08, 1.51)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab23_1_1_1_5 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>6.93</p>
|
|
<p>(0.69, 13.09)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab23_1_1_1_6 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab23_1_1_1_7 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab23_1_1_1_8 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_9 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_10 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_11 hd_b_ch2.apph.tab23_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab23_1_1_1_1 hd_h_ch2.apph.tab23_1_1_1_2 hd_h_ch2.apph.tab23_1_1_1_3 hd_h_ch2.apph.tab23_1_1_1_4 hd_h_ch2.apph.tab23_1_1_1_5 hd_h_ch2.apph.tab23_1_1_1_6 hd_h_ch2.apph.tab23_1_1_1_7 hd_h_ch2.apph.tab23_1_1_1_8 hd_h_ch2.apph.tab23_1_1_1_9 hd_h_ch2.apph.tab23_1_1_1_10 hd_h_ch2.apph.tab23_1_1_1_11" id="hd_b_ch2.apph.tab23_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 0 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab23_1_1_1_1 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>)</td><td headers="hd_h_ch2.apph.tab23_1_1_1_2 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab23_1_1_1_3 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_ch2.apph.tab23_1_1_1_4 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.15</p>
|
|
<p>(0.08, 16.67)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab23_1_1_1_5 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab23_1_1_1_6 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7 per 100</td><td headers="hd_h_ch2.apph.tab23_1_1_1_7 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>8 per 100</p>
|
|
<p>(1, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab23_1_1_1_8 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_9 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_10 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab23_1_1_1_11 hd_b_ch2.apph.tab23_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab23_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab23_2"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab23_3"><p class="no_margin">>33.3% of weighted data from studies which are partially directly applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab23_4"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab24"><div id="ch2.apph.tab24" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab24/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab24_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab24_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab24_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab24_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab24_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab24_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab24_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab24_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab24_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab24_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab24_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_h_ch2.apph.tab24_1_1_1_2 hd_h_ch2.apph.tab24_1_1_1_3 hd_h_ch2.apph.tab24_1_1_1_4 hd_h_ch2.apph.tab24_1_1_1_5 hd_h_ch2.apph.tab24_1_1_1_6 hd_h_ch2.apph.tab24_1_1_1_7 hd_h_ch2.apph.tab24_1_1_1_8 hd_h_ch2.apph.tab24_1_1_1_9 hd_h_ch2.apph.tab24_1_1_1_10 hd_h_ch2.apph.tab24_1_1_1_11" id="hd_b_ch2.apph.tab24_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group and computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab24_1_1_1_2 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab24_1_1_1_3 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch2.apph.tab24_1_1_1_4 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.00</p>
|
|
<p>(−0.38, 0.38)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_5 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.01</p>
|
|
<p>(−3.28, 3.29)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_6 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab24_1_1_1_7 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab24_1_1_1_8 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_9 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_10 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab24_1_1_1_11 hd_b_ch2.apph.tab24_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_h_ch2.apph.tab24_1_1_1_2 hd_h_ch2.apph.tab24_1_1_1_3 hd_h_ch2.apph.tab24_1_1_1_4 hd_h_ch2.apph.tab24_1_1_1_5 hd_h_ch2.apph.tab24_1_1_1_6 hd_h_ch2.apph.tab24_1_1_1_7 hd_h_ch2.apph.tab24_1_1_1_8 hd_h_ch2.apph.tab24_1_1_1_9 hd_h_ch2.apph.tab24_1_1_1_10 hd_h_ch2.apph.tab24_1_1_1_11" id="hd_b_ch2.apph.tab24_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group and computer CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab24_1_1_1_2 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab24_1_1_1_3 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch2.apph.tab24_1_1_1_4 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.00</p>
|
|
<p>(−0.38, 0.38)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_5 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>0.03</p>
|
|
<p>(−3.26, 3.32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_6 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab24_1_1_1_7 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab24_1_1_1_8 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_9 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_10 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab24_1_1_1_11 hd_b_ch2.apph.tab24_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_h_ch2.apph.tab24_1_1_1_2 hd_h_ch2.apph.tab24_1_1_1_3 hd_h_ch2.apph.tab24_1_1_1_4 hd_h_ch2.apph.tab24_1_1_1_5 hd_h_ch2.apph.tab24_1_1_1_6 hd_h_ch2.apph.tab24_1_1_1_7 hd_h_ch2.apph.tab24_1_1_1_8 hd_h_ch2.apph.tab24_1_1_1_9 hd_h_ch2.apph.tab24_1_1_1_10 hd_h_ch2.apph.tab24_1_1_1_11" id="hd_b_ch2.apph.tab24_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, RADS-2 (values lower than 0 favour group and computer CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab24_1_1_1_2 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab24_1_1_1_3 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch2.apph.tab24_1_1_1_4 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.04</p>
|
|
<p>(−0.42, 0.34)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_5 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.35</p>
|
|
<p>(−3.64, 2.95)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_6 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab24_1_1_1_7 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab24_1_1_1_8 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_9 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_10 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab24_1_1_1_11 hd_b_ch2.apph.tab24_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_h_ch2.apph.tab24_1_1_1_2 hd_h_ch2.apph.tab24_1_1_1_3 hd_h_ch2.apph.tab24_1_1_1_4 hd_h_ch2.apph.tab24_1_1_1_5 hd_h_ch2.apph.tab24_1_1_1_6 hd_h_ch2.apph.tab24_1_1_1_7 hd_h_ch2.apph.tab24_1_1_1_8 hd_h_ch2.apph.tab24_1_1_1_9 hd_h_ch2.apph.tab24_1_1_1_10 hd_h_ch2.apph.tab24_1_1_1_11" id="hd_b_ch2.apph.tab24_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, CDI item 9 score 2 (values lower than 1 favour group and computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab24_1_1_1_2 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab24_1_1_1_3 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_ch2.apph.tab24_1_1_1_4 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.73</p>
|
|
<p>(0.29, 25.44)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_5 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab24_1_1_1_6 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 per 100</td><td headers="hd_h_ch2.apph.tab24_1_1_1_7 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>5 per 100</p>
|
|
<p>(1, 50)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_8 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_9 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_10 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab24_1_1_1_11 hd_b_ch2.apph.tab24_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_h_ch2.apph.tab24_1_1_1_2 hd_h_ch2.apph.tab24_1_1_1_3 hd_h_ch2.apph.tab24_1_1_1_4 hd_h_ch2.apph.tab24_1_1_1_5 hd_h_ch2.apph.tab24_1_1_1_6 hd_h_ch2.apph.tab24_1_1_1_7 hd_h_ch2.apph.tab24_1_1_1_8 hd_h_ch2.apph.tab24_1_1_1_9 hd_h_ch2.apph.tab24_1_1_1_10 hd_h_ch2.apph.tab24_1_1_1_11" id="hd_b_ch2.apph.tab24_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group and computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab24_1_1_1_1 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref53" rid="ch2.appo.ref53">Poppelaars 2016</a>)</td><td headers="hd_h_ch2.apph.tab24_1_1_1_2 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab24_1_1_1_3 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">103</td><td headers="hd_h_ch2.apph.tab24_1_1_1_4 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 8.50</p>
|
|
<p>(0.47, 153.95)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_5 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab24_1_1_1_6 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 per 100</td><td headers="hd_h_ch2.apph.tab24_1_1_1_7 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>9 per 100</p>
|
|
<p>(0, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab24_1_1_1_8 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_9 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab24_1_1_1_10 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab24_1_1_1_11 hd_b_ch2.apph.tab24_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab24_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab24_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab25"><div id="ch2.apph.tab25" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab25/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab25_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab25_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab25_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab25_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab25_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab25_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab25_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab25_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab25_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab25_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab25_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_h_ch2.apph.tab25_1_1_1_2 hd_h_ch2.apph.tab25_1_1_1_3 hd_h_ch2.apph.tab25_1_1_1_4 hd_h_ch2.apph.tab25_1_1_1_5 hd_h_ch2.apph.tab25_1_1_1_6 hd_h_ch2.apph.tab25_1_1_1_7 hd_h_ch2.apph.tab25_1_1_1_8 hd_h_ch2.apph.tab25_1_1_1_9 hd_h_ch2.apph.tab25_1_1_1_10 hd_h_ch2.apph.tab25_1_1_1_11" id="hd_b_ch2.apph.tab25_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI-II (values lower than 0 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref17" rid="ch2.appo.ref17">Diamond 2010</a>)</td><td headers="hd_h_ch2.apph.tab25_1_1_1_2 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab25_1_1_1_3 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66</td><td headers="hd_h_ch2.apph.tab25_1_1_1_4 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.45</p>
|
|
<p>(−0.94, 0.04)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_5 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.9</p>
|
|
<p>(−8.15, 0.35)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_6 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_7 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_8 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_9 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab25_1_1_1_10 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_11 hd_b_ch2.apph.tab25_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_h_ch2.apph.tab25_1_1_1_2 hd_h_ch2.apph.tab25_1_1_1_3 hd_h_ch2.apph.tab25_1_1_1_4 hd_h_ch2.apph.tab25_1_1_1_5 hd_h_ch2.apph.tab25_1_1_1_6 hd_h_ch2.apph.tab25_1_1_1_7 hd_h_ch2.apph.tab25_1_1_1_8 hd_h_ch2.apph.tab25_1_1_1_9 hd_h_ch2.apph.tab25_1_1_1_10 hd_h_ch2.apph.tab25_1_1_1_11" id="hd_b_ch2.apph.tab25_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI-II (values lower than 0 favour family therapy) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref17" rid="ch2.appo.ref17">Diamond 2010</a>)</td><td headers="hd_h_ch2.apph.tab25_1_1_1_2 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab25_1_1_1_3 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66</td><td headers="hd_h_ch2.apph.tab25_1_1_1_4 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.28</p>
|
|
<p>(−0.77, 0.20)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_5 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>2.43 (−6.67, 1.73)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_6 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_7 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_8 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_9 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab25_1_1_1_10 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_11 hd_b_ch2.apph.tab25_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_h_ch2.apph.tab25_1_1_1_2 hd_h_ch2.apph.tab25_1_1_1_3 hd_h_ch2.apph.tab25_1_1_1_4 hd_h_ch2.apph.tab25_1_1_1_5 hd_h_ch2.apph.tab25_1_1_1_6 hd_h_ch2.apph.tab25_1_1_1_7 hd_h_ch2.apph.tab25_1_1_1_8 hd_h_ch2.apph.tab25_1_1_1_9 hd_h_ch2.apph.tab25_1_1_1_10 hd_h_ch2.apph.tab25_1_1_1_11" id="hd_b_ch2.apph.tab25_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref17" rid="ch2.appo.ref17">Diamond 2010</a>)</td><td headers="hd_h_ch2.apph.tab25_1_1_1_2 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab25_1_1_1_3 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26</td><td headers="hd_h_ch2.apph.tab25_1_1_1_4 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.77</p>
|
|
<p>(0.94, 3.32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_5 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_6 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31 per 100</td><td headers="hd_h_ch2.apph.tab25_1_1_1_7 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>55 per 100</p>
|
|
<p>(29, 103)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_8 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_9 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab25_1_1_1_10 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_11 hd_b_ch2.apph.tab25_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_h_ch2.apph.tab25_1_1_1_2 hd_h_ch2.apph.tab25_1_1_1_3 hd_h_ch2.apph.tab25_1_1_1_4 hd_h_ch2.apph.tab25_1_1_1_5 hd_h_ch2.apph.tab25_1_1_1_6 hd_h_ch2.apph.tab25_1_1_1_7 hd_h_ch2.apph.tab25_1_1_1_8 hd_h_ch2.apph.tab25_1_1_1_9 hd_h_ch2.apph.tab25_1_1_1_10 hd_h_ch2.apph.tab25_1_1_1_11" id="hd_b_ch2.apph.tab25_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour family therapy) – <6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref17" rid="ch2.appo.ref17">Diamond 2010</a>)</td><td headers="hd_h_ch2.apph.tab25_1_1_1_2 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab25_1_1_1_3 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_ch2.apph.tab25_1_1_1_4 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.51</p>
|
|
<p>(0.85, 2.67)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_5 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_6 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38 per 100</td><td headers="hd_h_ch2.apph.tab25_1_1_1_7 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>58 per 100</p>
|
|
<p>(33, 103)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_8 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_9 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab25_1_1_1_10 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_11 hd_b_ch2.apph.tab25_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_h_ch2.apph.tab25_1_1_1_2 hd_h_ch2.apph.tab25_1_1_1_3 hd_h_ch2.apph.tab25_1_1_1_4 hd_h_ch2.apph.tab25_1_1_1_5 hd_h_ch2.apph.tab25_1_1_1_6 hd_h_ch2.apph.tab25_1_1_1_7 hd_h_ch2.apph.tab25_1_1_1_8 hd_h_ch2.apph.tab25_1_1_1_9 hd_h_ch2.apph.tab25_1_1_1_10 hd_h_ch2.apph.tab25_1_1_1_11" id="hd_b_ch2.apph.tab25_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, SIQ-JR (values lower than 0 favour family therapy) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab25_1_1_1_1 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref17" rid="ch2.appo.ref17">Diamond 2010</a>)</td><td headers="hd_h_ch2.apph.tab25_1_1_1_2 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab25_1_1_1_3 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_ch2.apph.tab25_1_1_1_4 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −14.80</p>
|
|
<p>(−22.86, −6.74)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab25_1_1_1_5 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_6 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_7 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab25_1_1_1_8 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_9 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab25_1_1_1_10 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab25_1_1_1_11 hd_b_ch2.apph.tab25_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab25_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab25_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab25_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab26"><div id="ch2.apph.tab26" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab26/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab26_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab26_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab26_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab26_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab26_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab26_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab26_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab26_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab26_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab26_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab26_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab26_1_1_1_1 hd_h_ch2.apph.tab26_1_1_1_2 hd_h_ch2.apph.tab26_1_1_1_3 hd_h_ch2.apph.tab26_1_1_1_4 hd_h_ch2.apph.tab26_1_1_1_5 hd_h_ch2.apph.tab26_1_1_1_6 hd_h_ch2.apph.tab26_1_1_1_7 hd_h_ch2.apph.tab26_1_1_1_8 hd_h_ch2.apph.tab26_1_1_1_9 hd_h_ch2.apph.tab26_1_1_1_10 hd_h_ch2.apph.tab26_1_1_1_11" id="hd_b_ch2.apph.tab26_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour guided self-help) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab26_1_1_1_1 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref2" rid="ch2.appo.ref2">Ackerson 1998</a>)</td><td headers="hd_h_ch2.apph.tab26_1_1_1_2 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab26_1_1_1_3 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_ch2.apph.tab26_1_1_1_4 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −8.80</p>
|
|
<p>(−15.02, −2.58)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab26_1_1_1_5 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab26_1_1_1_6 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab26_1_1_1_7 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab26_1_1_1_8 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab26_1_1_1_9 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab26_1_1_1_10 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab26_1_1_1_11 hd_b_ch2.apph.tab26_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab26_1_1_1_1 hd_h_ch2.apph.tab26_1_1_1_2 hd_h_ch2.apph.tab26_1_1_1_3 hd_h_ch2.apph.tab26_1_1_1_4 hd_h_ch2.apph.tab26_1_1_1_5 hd_h_ch2.apph.tab26_1_1_1_6 hd_h_ch2.apph.tab26_1_1_1_7 hd_h_ch2.apph.tab26_1_1_1_8 hd_h_ch2.apph.tab26_1_1_1_9 hd_h_ch2.apph.tab26_1_1_1_10 hd_h_ch2.apph.tab26_1_1_1_11" id="hd_b_ch2.apph.tab26_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour guided self-help)</th></tr><tr><td headers="hd_h_ch2.apph.tab26_1_1_1_1 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref2" rid="ch2.appo.ref2">Ackerson 1998</a>)</td><td headers="hd_h_ch2.apph.tab26_1_1_1_2 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab26_1_1_1_3 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch2.apph.tab26_1_1_1_4 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.60</p>
|
|
<p>(0.17, 2.07)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab26_1_1_1_5 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab26_1_1_1_6 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33 per 100</td><td headers="hd_h_ch2.apph.tab26_1_1_1_7 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>20 per 100</p>
|
|
<p>(6, 69)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab26_1_1_1_8 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab26_1_1_1_9 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab26_1_1_1_10 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab26_1_1_1_11 hd_b_ch2.apph.tab26_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab26_1"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab26_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab27"><div id="ch2.apph.tab27" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab27/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab27_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab27_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab27_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab27_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab27_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab27_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab27_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab27_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab27_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab27_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab27_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab27_1_1_1_1 hd_h_ch2.apph.tab27_1_1_1_2 hd_h_ch2.apph.tab27_1_1_1_3 hd_h_ch2.apph.tab27_1_1_1_4 hd_h_ch2.apph.tab27_1_1_1_5 hd_h_ch2.apph.tab27_1_1_1_6 hd_h_ch2.apph.tab27_1_1_1_7 hd_h_ch2.apph.tab27_1_1_1_8 hd_h_ch2.apph.tab27_1_1_1_9 hd_h_ch2.apph.tab27_1_1_1_10 hd_h_ch2.apph.tab27_1_1_1_11" id="hd_b_ch2.apph.tab27_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour guided self-help) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab27_1_1_1_1 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref34" rid="ch2.appo.ref34">Jacob 2016</a>, <a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab27_1_1_1_2 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab27_1_1_1_3 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">194</td><td headers="hd_h_ch2.apph.tab27_1_1_1_4 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.85</p>
|
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<p>(−2.37, 0.68)</p>
|
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</td><td headers="hd_h_ch2.apph.tab27_1_1_1_5 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−7.37</p>
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<p>(−20.54, 5.89)</p>
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|
</td><td headers="hd_h_ch2.apph.tab27_1_1_1_6 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab27_1_1_1_7 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab27_1_1_1_8 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab27_1_1_1_9 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab27_1_1_1_10 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab27_1_1_1_11 hd_b_ch2.apph.tab27_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab27_1_1_1_1 hd_h_ch2.apph.tab27_1_1_1_2 hd_h_ch2.apph.tab27_1_1_1_3 hd_h_ch2.apph.tab27_1_1_1_4 hd_h_ch2.apph.tab27_1_1_1_5 hd_h_ch2.apph.tab27_1_1_1_6 hd_h_ch2.apph.tab27_1_1_1_7 hd_h_ch2.apph.tab27_1_1_1_8 hd_h_ch2.apph.tab27_1_1_1_9 hd_h_ch2.apph.tab27_1_1_1_10 hd_h_ch2.apph.tab27_1_1_1_11" id="hd_b_ch2.apph.tab27_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour guided self-help) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab27_1_1_1_1 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice, 2008</a>)</td><td headers="hd_h_ch2.apph.tab27_1_1_1_2 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab27_1_1_1_3 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">164</td><td headers="hd_h_ch2.apph.tab27_1_1_1_4 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.01</p>
|
|
<p>(−0.32, 0.30)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab27_1_1_1_5 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−0.09</p>
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|
<p>(−2.77, 2.6)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab27_1_1_1_6 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab27_1_1_1_7 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab27_1_1_1_8 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab27_1_1_1_9 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab27_1_1_1_10 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab27_1_1_1_11 hd_b_ch2.apph.tab27_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab27_1_1_1_1 hd_h_ch2.apph.tab27_1_1_1_2 hd_h_ch2.apph.tab27_1_1_1_3 hd_h_ch2.apph.tab27_1_1_1_4 hd_h_ch2.apph.tab27_1_1_1_5 hd_h_ch2.apph.tab27_1_1_1_6 hd_h_ch2.apph.tab27_1_1_1_7 hd_h_ch2.apph.tab27_1_1_1_8 hd_h_ch2.apph.tab27_1_1_1_9 hd_h_ch2.apph.tab27_1_1_1_10 hd_h_ch2.apph.tab27_1_1_1_11" id="hd_b_ch2.apph.tab27_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour guided self-help) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab27_1_1_1_1 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice, 2008</a>)</td><td headers="hd_h_ch2.apph.tab27_1_1_1_2 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab27_1_1_1_3 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">164</td><td headers="hd_h_ch2.apph.tab27_1_1_1_4 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.05</p>
|
|
<p>(−0.36, 0.26)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab27_1_1_1_5 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.78</p>
|
|
<p>(−24.01, 22.53)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab27_1_1_1_6 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab27_1_1_1_7 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab27_1_1_1_8 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab27_1_1_1_9 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab27_1_1_1_10 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab27_1_1_1_11 hd_b_ch2.apph.tab27_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab27_1_1_1_1 hd_h_ch2.apph.tab27_1_1_1_2 hd_h_ch2.apph.tab27_1_1_1_3 hd_h_ch2.apph.tab27_1_1_1_4 hd_h_ch2.apph.tab27_1_1_1_5 hd_h_ch2.apph.tab27_1_1_1_6 hd_h_ch2.apph.tab27_1_1_1_7 hd_h_ch2.apph.tab27_1_1_1_8 hd_h_ch2.apph.tab27_1_1_1_9 hd_h_ch2.apph.tab27_1_1_1_10 hd_h_ch2.apph.tab27_1_1_1_11" id="hd_b_ch2.apph.tab27_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour guided self-help)</th></tr><tr><td headers="hd_h_ch2.apph.tab27_1_1_1_1 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice, 2008</a>)</td><td headers="hd_h_ch2.apph.tab27_1_1_1_2 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab27_1_1_1_3 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">164</td><td headers="hd_h_ch2.apph.tab27_1_1_1_4 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.92</p>
|
|
<p>(1.02, 3.63)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab27_1_1_1_5 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab27_1_1_1_6 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 per 100</td><td headers="hd_h_ch2.apph.tab27_1_1_1_7 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>27 per 100</p>
|
|
<p>(15, 52)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab27_1_1_1_8 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab27_1_1_1_9 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab27_1_1_1_10 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab27_1_1_1_11 hd_b_ch2.apph.tab27_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab27_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab27_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab27_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab27_4"><p class="no_margin">I<sup>2</sup> is greater than 66.7%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab28"><div id="ch2.apph.tab28" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab28/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab28_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab28_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab28_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab28_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab28_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab28_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab28_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group IPT (95% CI)</th><th id="hd_h_ch2.apph.tab28_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab28_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab28_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab28_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab28_1_1_1_1 hd_h_ch2.apph.tab28_1_1_1_2 hd_h_ch2.apph.tab28_1_1_1_3 hd_h_ch2.apph.tab28_1_1_1_4 hd_h_ch2.apph.tab28_1_1_1_5 hd_h_ch2.apph.tab28_1_1_1_6 hd_h_ch2.apph.tab28_1_1_1_7 hd_h_ch2.apph.tab28_1_1_1_8 hd_h_ch2.apph.tab28_1_1_1_9 hd_h_ch2.apph.tab28_1_1_1_10 hd_h_ch2.apph.tab28_1_1_1_11" id="hd_b_ch2.apph.tab28_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group IPT)</th></tr><tr><td headers="hd_h_ch2.apph.tab28_1_1_1_1 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref6" rid="ch2.appo.ref6">Bolton 2007</a>)</td><td headers="hd_h_ch2.apph.tab28_1_1_1_2 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab28_1_1_1_3 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">209</td><td headers="hd_h_ch2.apph.tab28_1_1_1_4 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>RR 0.50</p>
|
|
<p>(0.21, 1.18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab28_1_1_1_5 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab28_1_1_1_6 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.46 per 100</td><td headers="hd_h_ch2.apph.tab28_1_1_1_7 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>6.73 per 100</p>
|
|
<p>(2.83, 15.88)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab28_1_1_1_8 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab28_1_1_1_9 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab28_1_1_1_10 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab28_1_1_1_11 hd_b_ch2.apph.tab28_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab28_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab28_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab29"><div id="ch2.apph.tab29" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab29/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab29_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab29_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab29_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab29_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab29_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab29_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: play therapy</th><th id="hd_h_ch2.apph.tab29_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group IPT (95% CI)</th><th id="hd_h_ch2.apph.tab29_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab29_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab29_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab29_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab29_1_1_1_1 hd_h_ch2.apph.tab29_1_1_1_2 hd_h_ch2.apph.tab29_1_1_1_3 hd_h_ch2.apph.tab29_1_1_1_4 hd_h_ch2.apph.tab29_1_1_1_5 hd_h_ch2.apph.tab29_1_1_1_6 hd_h_ch2.apph.tab29_1_1_1_7 hd_h_ch2.apph.tab29_1_1_1_8 hd_h_ch2.apph.tab29_1_1_1_9 hd_h_ch2.apph.tab29_1_1_1_10 hd_h_ch2.apph.tab29_1_1_1_11" id="hd_b_ch2.apph.tab29_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group IPT)</th></tr><tr><td headers="hd_h_ch2.apph.tab29_1_1_1_1 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref6" rid="ch2.appo.ref6">Bolton 2007</a>)</td><td headers="hd_h_ch2.apph.tab29_1_1_1_2 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab29_1_1_1_3 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">210</td><td headers="hd_h_ch2.apph.tab29_1_1_1_4 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.64</p>
|
|
<p>(0.26, 1.58)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab29_1_1_1_5 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.apph.tab29_1_1_1_6 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10.48 per 100</td><td headers="hd_h_ch2.apph.tab29_1_1_1_7 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>6.70 per 100</p>
|
|
<p>(2.72, 16.55)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab29_1_1_1_8 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab29_1_1_1_9 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab29_1_1_1_10 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab29_1_1_1_11 hd_b_ch2.apph.tab29_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab29_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab29_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab30"><div id="ch2.apph.tab30" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab30/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab30_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab30_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab30_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab30_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab30_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab30_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab30_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab30_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab30_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab30_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab30_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab30_1_1_1_1 hd_h_ch2.apph.tab30_1_1_1_2 hd_h_ch2.apph.tab30_1_1_1_3 hd_h_ch2.apph.tab30_1_1_1_4 hd_h_ch2.apph.tab30_1_1_1_5 hd_h_ch2.apph.tab30_1_1_1_6 hd_h_ch2.apph.tab30_1_1_1_7 hd_h_ch2.apph.tab30_1_1_1_8 hd_h_ch2.apph.tab30_1_1_1_9 hd_h_ch2.apph.tab30_1_1_1_10 hd_h_ch2.apph.tab30_1_1_1_11" id="hd_b_ch2.apph.tab30_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group IPT)</th></tr><tr><td headers="hd_h_ch2.apph.tab30_1_1_1_1 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref6" rid="ch2.appo.ref6">Bolton 2007</a>)</td><td headers="hd_h_ch2.apph.tab30_1_1_1_2 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab30_1_1_1_3 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">209</td><td headers="hd_h_ch2.apph.tab30_1_1_1_4 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.78</p>
|
|
<p>(0.37, 1.63)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab30_1_1_1_5 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.apph.tab30_1_1_1_6 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13.46 per 100</td><td headers="hd_h_ch2.apph.tab30_1_1_1_7 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>10.50 per 100</p>
|
|
<p>(4.98, 21.94)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab30_1_1_1_8 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab30_1_1_1_9 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab30_1_1_1_10 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab30_1_1_1_11 hd_b_ch2.apph.tab30_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab30_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab30_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab31"><div id="ch2.apph.tab31" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab31/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab31_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab31_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab31_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab31_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab31_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab31_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group NDST</th><th id="hd_h_ch2.apph.tab31_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group IPT (95% CI)</th><th id="hd_h_ch2.apph.tab31_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab31_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab31_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab31_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr><tr><th headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_1_11" id="hd_h_ch2.apph.tab31_1_1_2_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour group IPT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref82" rid="ch2.appo.ref82">Young 2006</a>, <a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>, <a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>)</td><td headers="hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">280</td><td headers="hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 1.44</p>
|
|
<p>(−2.31, 5.18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_11 hd_h_ch2.apph.tab31_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_1_11" id="hd_h_ch2.apph.tab31_1_1_4_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour group IPT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref82" rid="ch2.appo.ref82">Young 2006</a>, <a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>, <a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>)</td><td headers="hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">267</td><td headers="hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 1.50</p>
|
|
<p>(−3.51, 6.51)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_11 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_1_11" id="hd_h_ch2.apph.tab31_1_1_6_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour group IPT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>, <a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>)</td><td headers="hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">203</td><td headers="hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 0.10</p>
|
|
<p>(−1.75, 1.94)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_11 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_1_11" id="hd_h_ch2.apph.tab31_1_1_8_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group IPT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref82" rid="ch2.appo.ref82">Young 2006</a>, <a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>, <a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>)</td><td headers="hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">280</td><td headers="hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.51</p>
|
|
<p>(−0.93, −0.09)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−4.42</p>
|
|
<p>(−8.06, −0.78)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_11 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_1_11" id="hd_h_ch2.apph.tab31_1_1_10_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group IPT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref82" rid="ch2.appo.ref82">Young 2006</a>, <a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>, <a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>)</td><td headers="hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">280</td><td headers="hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.57</p>
|
|
<p>(−0.81, −0.32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−4.94</p>
|
|
<p>(−7.02, −2.77)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_11 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_1_11" id="hd_b_ch2.apph.tab31_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group IPT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref82" rid="ch2.appo.ref82">Young 2006</a>, <a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>, <a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>)</td><td headers="hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">245</td><td headers="hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.09</p>
|
|
<p>(−0.35, 0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.78</p>
|
|
<p>(−3.03, 1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_11 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_1_11" id="hd_b_ch2.apph.tab31_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group IPT)</th></tr><tr><td headers="hd_h_ch2.apph.tab31_1_1_1_1 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref82" rid="ch2.appo.ref82">Young 2006</a>, <a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>, <a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>)</td><td headers="hd_h_ch2.apph.tab31_1_1_1_2 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab31_1_1_1_3 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">280</td><td headers="hd_h_ch2.apph.tab31_1_1_1_4 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.78</p>
|
|
<p>(0.42, 1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_5 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab31_1_1_1_6 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 per 100</td><td headers="hd_h_ch2.apph.tab31_1_1_1_7 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>11 per 100</p>
|
|
<p>(6, 20)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab31_1_1_1_8 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab31_1_1_1_9 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_10 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab31_1_1_1_11 hd_h_ch2.apph.tab31_1_1_2_1 hd_h_ch2.apph.tab31_1_1_4_1 hd_h_ch2.apph.tab31_1_1_6_1 hd_h_ch2.apph.tab31_1_1_8_1 hd_h_ch2.apph.tab31_1_1_10_1 hd_b_ch2.apph.tab31_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab31_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab31_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab31_3"><p class="no_margin">I<sup>2</sup> is greater than 33.3%.</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab31_4"><p class="no_margin">I<sup>2</sup> is greater than 66.7%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab32"><div id="ch2.apph.tab32" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab32/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab32_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab32_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab32_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab32_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab32_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab32_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab32_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab32_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab32_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab32_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab32_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab32_1_1_1_1 hd_h_ch2.apph.tab32_1_1_1_2 hd_h_ch2.apph.tab32_1_1_1_3 hd_h_ch2.apph.tab32_1_1_1_4 hd_h_ch2.apph.tab32_1_1_1_5 hd_h_ch2.apph.tab32_1_1_1_6 hd_h_ch2.apph.tab32_1_1_1_7 hd_h_ch2.apph.tab32_1_1_1_8 hd_h_ch2.apph.tab32_1_1_1_9 hd_h_ch2.apph.tab32_1_1_1_10 hd_h_ch2.apph.tab32_1_1_1_11" id="hd_b_ch2.apph.tab32_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group non-directive supportive therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab32_1_1_1_1 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab32_1_1_1_2 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab32_1_1_1_3 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">172</td><td headers="hd_h_ch2.apph.tab32_1_1_1_4 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.27</p>
|
|
<p>(−0.57, 0.03)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab32_1_1_1_5 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.34</p>
|
|
<p>(−4.94, 0.26)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab32_1_1_1_6 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab32_1_1_1_7 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab32_1_1_1_8 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab32_1_1_1_9 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab32_1_1_1_10 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab32_1_1_1_11 hd_b_ch2.apph.tab32_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab32_1_1_1_1 hd_h_ch2.apph.tab32_1_1_1_2 hd_h_ch2.apph.tab32_1_1_1_3 hd_h_ch2.apph.tab32_1_1_1_4 hd_h_ch2.apph.tab32_1_1_1_5 hd_h_ch2.apph.tab32_1_1_1_6 hd_h_ch2.apph.tab32_1_1_1_7 hd_h_ch2.apph.tab32_1_1_1_8 hd_h_ch2.apph.tab32_1_1_1_9 hd_h_ch2.apph.tab32_1_1_1_10 hd_h_ch2.apph.tab32_1_1_1_11" id="hd_b_ch2.apph.tab32_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group non-directive supportive therapy) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab32_1_1_1_1 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab32_1_1_1_2 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab32_1_1_1_3 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">172</td><td headers="hd_h_ch2.apph.tab32_1_1_1_4 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.47</p>
|
|
<p>(−0.77, −0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab32_1_1_1_5 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−4.07</p>
|
|
<p>(−6.67, −1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab32_1_1_1_6 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab32_1_1_1_7 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab32_1_1_1_8 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab32_1_1_1_9 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab32_1_1_1_10 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab32_1_1_1_11 hd_b_ch2.apph.tab32_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab32_1_1_1_1 hd_h_ch2.apph.tab32_1_1_1_2 hd_h_ch2.apph.tab32_1_1_1_3 hd_h_ch2.apph.tab32_1_1_1_4 hd_h_ch2.apph.tab32_1_1_1_5 hd_h_ch2.apph.tab32_1_1_1_6 hd_h_ch2.apph.tab32_1_1_1_7 hd_h_ch2.apph.tab32_1_1_1_8 hd_h_ch2.apph.tab32_1_1_1_9 hd_h_ch2.apph.tab32_1_1_1_10 hd_h_ch2.apph.tab32_1_1_1_11" id="hd_b_ch2.apph.tab32_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group non-directive supportive therapy) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab32_1_1_1_1 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab32_1_1_1_2 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab32_1_1_1_3 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">172</td><td headers="hd_h_ch2.apph.tab32_1_1_1_4 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.32</p>
|
|
<p>(−0.62, −0.02)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab32_1_1_1_5 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.77</p>
|
|
<p>(−5.37, −0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab32_1_1_1_6 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab32_1_1_1_7 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab32_1_1_1_8 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab32_1_1_1_9 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab32_1_1_1_10 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab32_1_1_1_11 hd_b_ch2.apph.tab32_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab32_1_1_1_1 hd_h_ch2.apph.tab32_1_1_1_2 hd_h_ch2.apph.tab32_1_1_1_3 hd_h_ch2.apph.tab32_1_1_1_4 hd_h_ch2.apph.tab32_1_1_1_5 hd_h_ch2.apph.tab32_1_1_1_6 hd_h_ch2.apph.tab32_1_1_1_7 hd_h_ch2.apph.tab32_1_1_1_8 hd_h_ch2.apph.tab32_1_1_1_9 hd_h_ch2.apph.tab32_1_1_1_10 hd_h_ch2.apph.tab32_1_1_1_11" id="hd_b_ch2.apph.tab32_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group non-directive supportive therapy)</th></tr><tr><td headers="hd_h_ch2.apph.tab32_1_1_1_1 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab32_1_1_1_2 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab32_1_1_1_3 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">159</td><td headers="hd_h_ch2.apph.tab32_1_1_1_4 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.15</p>
|
|
<p>(1.15, 4.01)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab32_1_1_1_5 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab32_1_1_1_6 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 per 100</td><td headers="hd_h_ch2.apph.tab32_1_1_1_7 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>31 per 100</p>
|
|
<p>(16, 57)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab32_1_1_1_8 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab32_1_1_1_9 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab32_1_1_1_10 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab32_1_1_1_11 hd_b_ch2.apph.tab32_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab32_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab32_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab32_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab33"><div id="ch2.apph.tab33" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab33/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab33_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab33_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab33_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab33_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab33_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab33_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: guided self-help</th><th id="hd_h_ch2.apph.tab33_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group NDST (95% CI)</th><th id="hd_h_ch2.apph.tab33_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab33_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab33_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab33_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab33_1_1_1_1 hd_h_ch2.apph.tab33_1_1_1_2 hd_h_ch2.apph.tab33_1_1_1_3 hd_h_ch2.apph.tab33_1_1_1_4 hd_h_ch2.apph.tab33_1_1_1_5 hd_h_ch2.apph.tab33_1_1_1_6 hd_h_ch2.apph.tab33_1_1_1_7 hd_h_ch2.apph.tab33_1_1_1_8 hd_h_ch2.apph.tab33_1_1_1_9 hd_h_ch2.apph.tab33_1_1_1_10 hd_h_ch2.apph.tab33_1_1_1_11" id="hd_b_ch2.apph.tab33_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group non-directive supportive therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab33_1_1_1_1 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab33_1_1_1_2 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab33_1_1_1_3 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">168</td><td headers="hd_h_ch2.apph.tab33_1_1_1_4 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.17</p>
|
|
<p>(−0.48, 0.13)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab33_1_1_1_5 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.47</p>
|
|
<p>(−4.16, 1.13)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab33_1_1_1_6 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab33_1_1_1_7 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab33_1_1_1_8 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab33_1_1_1_9 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab33_1_1_1_10 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab33_1_1_1_11 hd_b_ch2.apph.tab33_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab33_1_1_1_1 hd_h_ch2.apph.tab33_1_1_1_2 hd_h_ch2.apph.tab33_1_1_1_3 hd_h_ch2.apph.tab33_1_1_1_4 hd_h_ch2.apph.tab33_1_1_1_5 hd_h_ch2.apph.tab33_1_1_1_6 hd_h_ch2.apph.tab33_1_1_1_7 hd_h_ch2.apph.tab33_1_1_1_8 hd_h_ch2.apph.tab33_1_1_1_9 hd_h_ch2.apph.tab33_1_1_1_10 hd_h_ch2.apph.tab33_1_1_1_11" id="hd_b_ch2.apph.tab33_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group non-directive supportive therapy) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab33_1_1_1_1 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab33_1_1_1_2 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab33_1_1_1_3 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">168</td><td headers="hd_h_ch2.apph.tab33_1_1_1_4 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.48</p>
|
|
<p>(−0.79, −0.18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab33_1_1_1_5 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−4.16</p>
|
|
<p>(−6.85, −1.56)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab33_1_1_1_6 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab33_1_1_1_7 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab33_1_1_1_8 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab33_1_1_1_9 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab33_1_1_1_10 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab33_1_1_1_11 hd_b_ch2.apph.tab33_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab33_1_1_1_1 hd_h_ch2.apph.tab33_1_1_1_2 hd_h_ch2.apph.tab33_1_1_1_3 hd_h_ch2.apph.tab33_1_1_1_4 hd_h_ch2.apph.tab33_1_1_1_5 hd_h_ch2.apph.tab33_1_1_1_6 hd_h_ch2.apph.tab33_1_1_1_7 hd_h_ch2.apph.tab33_1_1_1_8 hd_h_ch2.apph.tab33_1_1_1_9 hd_h_ch2.apph.tab33_1_1_1_10 hd_h_ch2.apph.tab33_1_1_1_11" id="hd_b_ch2.apph.tab33_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group non-directive supportive therapy) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab33_1_1_1_1 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab33_1_1_1_2 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab33_1_1_1_3 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">168</td><td headers="hd_h_ch2.apph.tab33_1_1_1_4 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.28</p>
|
|
<p>(−0.59, 0.02)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab33_1_1_1_5 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.43</p>
|
|
<p>(−5.11, 0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab33_1_1_1_6 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab33_1_1_1_7 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab33_1_1_1_8 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab33_1_1_1_9 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab33_1_1_1_10 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab33_1_1_1_11 hd_b_ch2.apph.tab33_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab33_1_1_1_1 hd_h_ch2.apph.tab33_1_1_1_2 hd_h_ch2.apph.tab33_1_1_1_3 hd_h_ch2.apph.tab33_1_1_1_4 hd_h_ch2.apph.tab33_1_1_1_5 hd_h_ch2.apph.tab33_1_1_1_6 hd_h_ch2.apph.tab33_1_1_1_7 hd_h_ch2.apph.tab33_1_1_1_8 hd_h_ch2.apph.tab33_1_1_1_9 hd_h_ch2.apph.tab33_1_1_1_10 hd_h_ch2.apph.tab33_1_1_1_11" id="hd_b_ch2.apph.tab33_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group non-directive supportive therapy)</th></tr><tr><td headers="hd_h_ch2.apph.tab33_1_1_1_1 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>)</td><td headers="hd_h_ch2.apph.tab33_1_1_1_2 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab33_1_1_1_3 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45</td><td headers="hd_h_ch2.apph.tab33_1_1_1_4 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.12</p>
|
|
<p>(0.68, 1.82)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab33_1_1_1_5 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab33_1_1_1_6 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28 per 100</td><td headers="hd_h_ch2.apph.tab33_1_1_1_7 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>31 per 100</p>
|
|
<p>(19, 50)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab33_1_1_1_8 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab33_1_1_1_9 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab33_1_1_1_10 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab33_1_1_1_11 hd_b_ch2.apph.tab33_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab33_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab33_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab33_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab34"><div id="ch2.apph.tab34" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab34/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab34_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab34_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab34_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab34_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab34_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab34_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab34_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab34_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab34_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab34_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab34_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab34_1_1_1_1 hd_h_ch2.apph.tab34_1_1_1_2 hd_h_ch2.apph.tab34_1_1_1_3 hd_h_ch2.apph.tab34_1_1_1_4 hd_h_ch2.apph.tab34_1_1_1_5 hd_h_ch2.apph.tab34_1_1_1_6 hd_h_ch2.apph.tab34_1_1_1_7 hd_h_ch2.apph.tab34_1_1_1_8 hd_h_ch2.apph.tab34_1_1_1_9 hd_h_ch2.apph.tab34_1_1_1_10 hd_h_ch2.apph.tab34_1_1_1_11" id="hd_b_ch2.apph.tab34_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour relaxation) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab34_1_1_1_1 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>)</td><td headers="hd_h_ch2.apph.tab34_1_1_1_2 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab34_1_1_1_3 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18</td><td headers="hd_h_ch2.apph.tab34_1_1_1_4 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −1.64</p>
|
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<p>(−2.75, −0.53)</p>
|
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</td><td headers="hd_h_ch2.apph.tab34_1_1_1_5 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
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<p>−14.21</p>
|
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<p>(−23.83, −4.59)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab34_1_1_1_6 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab34_1_1_1_7 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab34_1_1_1_8 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab34_1_1_1_9 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab34_1_1_1_10 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab34_1_1_1_11 hd_b_ch2.apph.tab34_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab34_1_1_1_1 hd_h_ch2.apph.tab34_1_1_1_2 hd_h_ch2.apph.tab34_1_1_1_3 hd_h_ch2.apph.tab34_1_1_1_4 hd_h_ch2.apph.tab34_1_1_1_5 hd_h_ch2.apph.tab34_1_1_1_6 hd_h_ch2.apph.tab34_1_1_1_7 hd_h_ch2.apph.tab34_1_1_1_8 hd_h_ch2.apph.tab34_1_1_1_9 hd_h_ch2.apph.tab34_1_1_1_10 hd_h_ch2.apph.tab34_1_1_1_11" id="hd_b_ch2.apph.tab34_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour relaxation) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab34_1_1_1_1 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>, <a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>)</td><td headers="hd_h_ch2.apph.tab34_1_1_1_2 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab34_1_1_1_3 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49</td><td headers="hd_h_ch2.apph.tab34_1_1_1_4 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.71</p>
|
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<p>(−1.30, −0.12)</p>
|
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</td><td headers="hd_h_ch2.apph.tab34_1_1_1_5 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
|
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<p>−6.15</p>
|
|
<p>(−11.27, −1.04)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab34_1_1_1_6 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab34_1_1_1_7 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab34_1_1_1_8 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab34_1_1_1_9 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab34_1_1_1_10 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab34_1_1_1_11 hd_b_ch2.apph.tab34_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab34_1_1_1_1 hd_h_ch2.apph.tab34_1_1_1_2 hd_h_ch2.apph.tab34_1_1_1_3 hd_h_ch2.apph.tab34_1_1_1_4 hd_h_ch2.apph.tab34_1_1_1_5 hd_h_ch2.apph.tab34_1_1_1_6 hd_h_ch2.apph.tab34_1_1_1_7 hd_h_ch2.apph.tab34_1_1_1_8 hd_h_ch2.apph.tab34_1_1_1_9 hd_h_ch2.apph.tab34_1_1_1_10 hd_h_ch2.apph.tab34_1_1_1_11" id="hd_b_ch2.apph.tab34_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour relaxation)</th></tr><tr><td headers="hd_h_ch2.apph.tab34_1_1_1_1 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref55" rid="ch2.appo.ref55">Reynolds 1986</a>)</td><td headers="hd_h_ch2.apph.tab34_1_1_1_2 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab34_1_1_1_3 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_ch2.apph.tab34_1_1_1_4 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>RR 4.55</p>
|
|
<p>(0.63, 32.56)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab34_1_1_1_5 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab34_1_1_1_6 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10 per 100</td><td headers="hd_h_ch2.apph.tab34_1_1_1_7 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>46 per 100</p>
|
|
<p>(6, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab34_1_1_1_8 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab34_1_1_1_9 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab34_1_1_1_10 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab34_1_1_1_11 hd_b_ch2.apph.tab34_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab34_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab34_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab34_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab35"><div id="ch2.apph.tab35" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab35/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab35_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab35_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab35_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab35_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab35_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab35_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: self-modelling</th><th id="hd_h_ch2.apph.tab35_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: relaxation (95% CI)</th><th id="hd_h_ch2.apph.tab35_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab35_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab35_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab35_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab35_1_1_1_1 hd_h_ch2.apph.tab35_1_1_1_2 hd_h_ch2.apph.tab35_1_1_1_3 hd_h_ch2.apph.tab35_1_1_1_4 hd_h_ch2.apph.tab35_1_1_1_5 hd_h_ch2.apph.tab35_1_1_1_6 hd_h_ch2.apph.tab35_1_1_1_7 hd_h_ch2.apph.tab35_1_1_1_8 hd_h_ch2.apph.tab35_1_1_1_9 hd_h_ch2.apph.tab35_1_1_1_10 hd_h_ch2.apph.tab35_1_1_1_11" id="hd_b_ch2.apph.tab35_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour relaxation) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab35_1_1_1_1 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>)</td><td headers="hd_h_ch2.apph.tab35_1_1_1_2 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab35_1_1_1_3 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_ch2.apph.tab35_1_1_1_4 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −2.43</p>
|
|
<p>(−10.23, 5.37)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab35_1_1_1_5 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab35_1_1_1_6 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab35_1_1_1_7 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab35_1_1_1_8 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab35_1_1_1_9 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab35_1_1_1_10 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab35_1_1_1_11 hd_b_ch2.apph.tab35_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab35_1_1_1_1 hd_h_ch2.apph.tab35_1_1_1_2 hd_h_ch2.apph.tab35_1_1_1_3 hd_h_ch2.apph.tab35_1_1_1_4 hd_h_ch2.apph.tab35_1_1_1_5 hd_h_ch2.apph.tab35_1_1_1_6 hd_h_ch2.apph.tab35_1_1_1_7 hd_h_ch2.apph.tab35_1_1_1_8 hd_h_ch2.apph.tab35_1_1_1_9 hd_h_ch2.apph.tab35_1_1_1_10 hd_h_ch2.apph.tab35_1_1_1_11" id="hd_b_ch2.apph.tab35_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour relaxation) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab35_1_1_1_1 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>)</td><td headers="hd_h_ch2.apph.tab35_1_1_1_2 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab35_1_1_1_3 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_ch2.apph.tab35_1_1_1_4 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −2.44</p>
|
|
<p>(−10.75, 5.87)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab35_1_1_1_5 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab35_1_1_1_6 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab35_1_1_1_7 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab35_1_1_1_8 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab35_1_1_1_9 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab35_1_1_1_10 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab35_1_1_1_11 hd_b_ch2.apph.tab35_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab35_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab35_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab36"><div id="ch2.apph.tab36" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab36/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab36_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab36_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab36_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab36_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab36_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab36_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab36_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab36_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab36_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab36_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab36_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab36_1_1_1_1 hd_h_ch2.apph.tab36_1_1_1_2 hd_h_ch2.apph.tab36_1_1_1_3 hd_h_ch2.apph.tab36_1_1_1_4 hd_h_ch2.apph.tab36_1_1_1_5 hd_h_ch2.apph.tab36_1_1_1_6 hd_h_ch2.apph.tab36_1_1_1_7 hd_h_ch2.apph.tab36_1_1_1_8 hd_h_ch2.apph.tab36_1_1_1_9 hd_h_ch2.apph.tab36_1_1_1_10 hd_h_ch2.apph.tab36_1_1_1_11" id="hd_b_ch2.apph.tab36_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour self-modelling) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab36_1_1_1_1 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>)</td><td headers="hd_h_ch2.apph.tab36_1_1_1_2 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab36_1_1_1_3 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_ch2.apph.tab36_1_1_1_4 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>MD −6.24</p>
|
|
<p>(−16.99, 4.51)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab36_1_1_1_5 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab36_1_1_1_6 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab36_1_1_1_7 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab36_1_1_1_8 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab36_1_1_1_9 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab36_1_1_1_10 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab36_1_1_1_11 hd_b_ch2.apph.tab36_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab36_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab36_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab37"><div id="ch2.apph.tab37" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab37/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab37_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab37_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab37_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab37_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab37_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab37_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab37_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab37_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab37_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab37_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab37_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab37_1_1_1_1 hd_h_ch2.apph.tab37_1_1_1_2 hd_h_ch2.apph.tab37_1_1_1_3 hd_h_ch2.apph.tab37_1_1_1_4 hd_h_ch2.apph.tab37_1_1_1_5 hd_h_ch2.apph.tab37_1_1_1_6 hd_h_ch2.apph.tab37_1_1_1_7 hd_h_ch2.apph.tab37_1_1_1_8 hd_h_ch2.apph.tab37_1_1_1_9 hd_h_ch2.apph.tab37_1_1_1_10 hd_h_ch2.apph.tab37_1_1_1_11" id="hd_b_ch2.apph.tab37_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, SCL-90-R (values lower than 0 favour dance therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab37_1_1_1_1 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref35" rid="ch2.appo.ref35">Jeong 2005</a>)</td><td headers="hd_h_ch2.apph.tab37_1_1_1_2 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab37_1_1_1_3 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_ch2.apph.tab37_1_1_1_4 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.87</p>
|
|
<p>(−1.52, −0.22)</p>
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|
</td><td headers="hd_h_ch2.apph.tab37_1_1_1_5 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−7.54</p>
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<p>(−13.17, −1.91)</p>
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|
</td><td headers="hd_h_ch2.apph.tab37_1_1_1_6 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab37_1_1_1_7 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab37_1_1_1_8 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab37_1_1_1_9 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab37_1_1_1_10 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab37_1_1_1_11 hd_b_ch2.apph.tab37_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab37_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab37_2"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab37_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab38"><div id="ch2.apph.tab38" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab38/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab38_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab38_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab38_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab38_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab38_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab38_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab38_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab38_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab38_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab38_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab38_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab38_1_1_1_1 hd_h_ch2.apph.tab38_1_1_1_2 hd_h_ch2.apph.tab38_1_1_1_3 hd_h_ch2.apph.tab38_1_1_1_4 hd_h_ch2.apph.tab38_1_1_1_5 hd_h_ch2.apph.tab38_1_1_1_6 hd_h_ch2.apph.tab38_1_1_1_7 hd_h_ch2.apph.tab38_1_1_1_8 hd_h_ch2.apph.tab38_1_1_1_9 hd_h_ch2.apph.tab38_1_1_1_10 hd_h_ch2.apph.tab38_1_1_1_11" id="hd_b_ch2.apph.tab38_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour individual CBT) – Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab38_1_1_1_1 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref78" rid="ch2.appo.ref78">Weisz (2009)</a></td><td headers="hd_h_ch2.apph.tab38_1_1_1_2 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab38_1_1_1_3 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44</td><td headers="hd_h_ch2.apph.tab38_1_1_1_4 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>MD −0.06</p>
|
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<p>(−4.71, 4.59)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab38_1_1_1_5 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab38_1_1_1_6 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab38_1_1_1_7 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab38_1_1_1_8 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab38_1_1_1_9 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab38_1_1_1_10 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab38_1_1_1_11 hd_b_ch2.apph.tab38_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab38_1"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab38_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab39"><div id="ch2.apph.tab39" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab39/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab39_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab39_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab39_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab39_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab39_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab39_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab39_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab39_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab39_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab39_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab39_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab39_1_1_1_1 hd_h_ch2.apph.tab39_1_1_1_2 hd_h_ch2.apph.tab39_1_1_1_3 hd_h_ch2.apph.tab39_1_1_1_4 hd_h_ch2.apph.tab39_1_1_1_5 hd_h_ch2.apph.tab39_1_1_1_6 hd_h_ch2.apph.tab39_1_1_1_7 hd_h_ch2.apph.tab39_1_1_1_8 hd_h_ch2.apph.tab39_1_1_1_9 hd_h_ch2.apph.tab39_1_1_1_10 hd_h_ch2.apph.tab39_1_1_1_11" id="hd_b_ch2.apph.tab39_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour group CBT)– Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab39_1_1_1_1 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref42" rid="ch2.appo.ref42">Liddle (1990)</a></td><td headers="hd_h_ch2.apph.tab39_1_1_1_2 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab39_1_1_1_3 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_ch2.apph.tab39_1_1_1_4 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −3.55</p>
|
|
<p>(−8.69, 1.59)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab39_1_1_1_5 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab39_1_1_1_6 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab39_1_1_1_7 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab39_1_1_1_8 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab39_1_1_1_9 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab39_1_1_1_10 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab39_1_1_1_11 hd_b_ch2.apph.tab39_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab39_1_1_1_1 hd_h_ch2.apph.tab39_1_1_1_2 hd_h_ch2.apph.tab39_1_1_1_3 hd_h_ch2.apph.tab39_1_1_1_4 hd_h_ch2.apph.tab39_1_1_1_5 hd_h_ch2.apph.tab39_1_1_1_6 hd_h_ch2.apph.tab39_1_1_1_7 hd_h_ch2.apph.tab39_1_1_1_8 hd_h_ch2.apph.tab39_1_1_1_9 hd_h_ch2.apph.tab39_1_1_1_10 hd_h_ch2.apph.tab39_1_1_1_11" id="hd_b_ch2.apph.tab39_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab39_1_1_1_1 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref42" rid="ch2.appo.ref42">Liddle (1990)</a></td><td headers="hd_h_ch2.apph.tab39_1_1_1_2 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab39_1_1_1_3 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_ch2.apph.tab39_1_1_1_4 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −1.56</p>
|
|
<p>(−6.73, 3.61)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab39_1_1_1_5 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab39_1_1_1_6 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab39_1_1_1_7 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab39_1_1_1_8 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab39_1_1_1_9 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab39_1_1_1_10 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab39_1_1_1_11 hd_b_ch2.apph.tab39_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab39_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab39_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab40"><div id="ch2.apph.tab40" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab40/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab40_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab40_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab40_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab40_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab40_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab40_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab40_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab40_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab40_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab40_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab40_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab40_1_1_1_1 hd_h_ch2.apph.tab40_1_1_1_2 hd_h_ch2.apph.tab40_1_1_1_3 hd_h_ch2.apph.tab40_1_1_1_4 hd_h_ch2.apph.tab40_1_1_1_5 hd_h_ch2.apph.tab40_1_1_1_6 hd_h_ch2.apph.tab40_1_1_1_7 hd_h_ch2.apph.tab40_1_1_1_8 hd_h_ch2.apph.tab40_1_1_1_9 hd_h_ch2.apph.tab40_1_1_1_10 hd_h_ch2.apph.tab40_1_1_1_11" id="hd_b_ch2.apph.tab40_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour group CBT)– Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab40_1_1_1_1 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref42" rid="ch2.appo.ref42">Liddle (1990)</a></td><td headers="hd_h_ch2.apph.tab40_1_1_1_2 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab40_1_1_1_3 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_ch2.apph.tab40_1_1_1_4 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −2.75</p>
|
|
<p>(−7.81, 2.31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab40_1_1_1_5 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab40_1_1_1_6 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab40_1_1_1_7 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab40_1_1_1_8 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab40_1_1_1_9 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab40_1_1_1_10 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab40_1_1_1_11 hd_b_ch2.apph.tab40_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab40_1_1_1_1 hd_h_ch2.apph.tab40_1_1_1_2 hd_h_ch2.apph.tab40_1_1_1_3 hd_h_ch2.apph.tab40_1_1_1_4 hd_h_ch2.apph.tab40_1_1_1_5 hd_h_ch2.apph.tab40_1_1_1_6 hd_h_ch2.apph.tab40_1_1_1_7 hd_h_ch2.apph.tab40_1_1_1_8 hd_h_ch2.apph.tab40_1_1_1_9 hd_h_ch2.apph.tab40_1_1_1_10 hd_h_ch2.apph.tab40_1_1_1_11" id="hd_b_ch2.apph.tab40_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab40_1_1_1_1 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref42" rid="ch2.appo.ref42">Liddle (1990)</a></td><td headers="hd_h_ch2.apph.tab40_1_1_1_2 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab40_1_1_1_3 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_ch2.apph.tab40_1_1_1_4 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −1.56</p>
|
|
<p>(−6.12, 3.00)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab40_1_1_1_5 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab40_1_1_1_6 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab40_1_1_1_7 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab40_1_1_1_8 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab40_1_1_1_9 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab40_1_1_1_10 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab40_1_1_1_11 hd_b_ch2.apph.tab40_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab40_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab40_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab41"><div id="ch2.apph.tab41" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab41/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab41_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab41_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab41_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab41_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab41_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab41_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab41_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab41_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab41_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab41_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab41_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab41_1_1_1_1 hd_h_ch2.apph.tab41_1_1_1_2 hd_h_ch2.apph.tab41_1_1_1_3 hd_h_ch2.apph.tab41_1_1_1_4 hd_h_ch2.apph.tab41_1_1_1_5 hd_h_ch2.apph.tab41_1_1_1_6 hd_h_ch2.apph.tab41_1_1_1_7 hd_h_ch2.apph.tab41_1_1_1_8 hd_h_ch2.apph.tab41_1_1_1_9 hd_h_ch2.apph.tab41_1_1_1_10 hd_h_ch2.apph.tab41_1_1_1_11" id="hd_b_ch2.apph.tab41_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS-R (values lower than 0 favour family psychoeducation with CBT) – Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab41_1_1_1_1 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref24" rid="ch2.appo.ref24">Fristad (2016)</a></td><td headers="hd_h_ch2.apph.tab41_1_1_1_2 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab41_1_1_1_3 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_ch2.apph.tab41_1_1_1_4 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD 0.09</p>
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<p>(−0.55, 0.74)</p>
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</td><td headers="hd_h_ch2.apph.tab41_1_1_1_5 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>CDI scale<sup>*</sup></p>
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<p>MD 0.78</p>
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<p>(−4.77, 6.41)</p>
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</td><td headers="hd_h_ch2.apph.tab41_1_1_1_6 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab41_1_1_1_7 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab41_1_1_1_8 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab41_1_1_1_9 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab41_1_1_1_10 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab41_1_1_1_11 hd_b_ch2.apph.tab41_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab41_1_1_1_1 hd_h_ch2.apph.tab41_1_1_1_2 hd_h_ch2.apph.tab41_1_1_1_3 hd_h_ch2.apph.tab41_1_1_1_4 hd_h_ch2.apph.tab41_1_1_1_5 hd_h_ch2.apph.tab41_1_1_1_6 hd_h_ch2.apph.tab41_1_1_1_7 hd_h_ch2.apph.tab41_1_1_1_8 hd_h_ch2.apph.tab41_1_1_1_9 hd_h_ch2.apph.tab41_1_1_1_10 hd_h_ch2.apph.tab41_1_1_1_11" id="hd_b_ch2.apph.tab41_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour family psychoeducation with CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab41_1_1_1_1 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref24" rid="ch2.appo.ref24">Fristad (2016)</a></td><td headers="hd_h_ch2.apph.tab41_1_1_1_2 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab41_1_1_1_3 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_ch2.apph.tab41_1_1_1_4 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>RR 1.14</p>
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<p>(0.66, 1.95)</p>
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</td><td headers="hd_h_ch2.apph.tab41_1_1_1_5 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab41_1_1_1_6 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56 per 100</td><td headers="hd_h_ch2.apph.tab41_1_1_1_7 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>63 per 100</p>
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<p>(37, 100)</p>
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</td><td headers="hd_h_ch2.apph.tab41_1_1_1_8 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab41_1_1_1_9 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab41_1_1_1_10 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab41_1_1_1_11 hd_b_ch2.apph.tab41_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab41_1_1_1_1 hd_h_ch2.apph.tab41_1_1_1_2 hd_h_ch2.apph.tab41_1_1_1_3 hd_h_ch2.apph.tab41_1_1_1_4 hd_h_ch2.apph.tab41_1_1_1_5 hd_h_ch2.apph.tab41_1_1_1_6 hd_h_ch2.apph.tab41_1_1_1_7 hd_h_ch2.apph.tab41_1_1_1_8 hd_h_ch2.apph.tab41_1_1_1_9 hd_h_ch2.apph.tab41_1_1_1_10 hd_h_ch2.apph.tab41_1_1_1_11" id="hd_b_ch2.apph.tab41_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour family psychoeducation with CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab41_1_1_1_1 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref24" rid="ch2.appo.ref24">Fristad (2016)</a></td><td headers="hd_h_ch2.apph.tab41_1_1_1_2 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab41_1_1_1_3 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_ch2.apph.tab41_1_1_1_4 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>RR 0.63</p>
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<p>(0.12, 3.35)</p>
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</td><td headers="hd_h_ch2.apph.tab41_1_1_1_5 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab41_1_1_1_6 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17 per 100</td><td headers="hd_h_ch2.apph.tab41_1_1_1_7 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>11 per 100</p>
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<p>(2, 56)</p>
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</td><td headers="hd_h_ch2.apph.tab41_1_1_1_8 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab41_1_1_1_9 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab41_1_1_1_10 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab41_1_1_1_11 hd_b_ch2.apph.tab41_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab41_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab41_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab41_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab42"><div id="ch2.apph.tab42" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab42/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab42_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab42_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab42_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab42_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab42_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab42_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: NDST</th><th id="hd_h_ch2.apph.tab42_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: family therapy (95% CI)</th><th id="hd_h_ch2.apph.tab42_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab42_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab42_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab42_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab42_1_1_1_1 hd_h_ch2.apph.tab42_1_1_1_2 hd_h_ch2.apph.tab42_1_1_1_3 hd_h_ch2.apph.tab42_1_1_1_4 hd_h_ch2.apph.tab42_1_1_1_5 hd_h_ch2.apph.tab42_1_1_1_6 hd_h_ch2.apph.tab42_1_1_1_7 hd_h_ch2.apph.tab42_1_1_1_8 hd_h_ch2.apph.tab42_1_1_1_9 hd_h_ch2.apph.tab42_1_1_1_10 hd_h_ch2.apph.tab42_1_1_1_11" id="hd_b_ch2.apph.tab42_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab42_1_1_1_1 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref70" rid="ch2.appo.ref70">Tompson (2017)</a></td><td headers="hd_h_ch2.apph.tab42_1_1_1_2 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab42_1_1_1_3 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">134</td><td headers="hd_h_ch2.apph.tab42_1_1_1_4 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>MD −0.14</p>
|
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<p>(−3.14, 2.86)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab42_1_1_1_5 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab42_1_1_1_6 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab42_1_1_1_7 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab42_1_1_1_8 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab42_1_1_1_9 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab42_1_1_1_10 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab42_1_1_1_11 hd_b_ch2.apph.tab42_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab42_1_1_1_1 hd_h_ch2.apph.tab42_1_1_1_2 hd_h_ch2.apph.tab42_1_1_1_3 hd_h_ch2.apph.tab42_1_1_1_4 hd_h_ch2.apph.tab42_1_1_1_5 hd_h_ch2.apph.tab42_1_1_1_6 hd_h_ch2.apph.tab42_1_1_1_7 hd_h_ch2.apph.tab42_1_1_1_8 hd_h_ch2.apph.tab42_1_1_1_9 hd_h_ch2.apph.tab42_1_1_1_10 hd_h_ch2.apph.tab42_1_1_1_11" id="hd_b_ch2.apph.tab42_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour family therapy) – Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab42_1_1_1_1 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref70" rid="ch2.appo.ref70">Tompson (2017)</a></td><td headers="hd_h_ch2.apph.tab42_1_1_1_2 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab42_1_1_1_3 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">134</td><td headers="hd_h_ch2.apph.tab42_1_1_1_4 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD −2.54 (−6.49, 1.41)</td><td headers="hd_h_ch2.apph.tab42_1_1_1_5 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab42_1_1_1_6 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab42_1_1_1_7 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab42_1_1_1_8 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab42_1_1_1_9 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab42_1_1_1_10 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab42_1_1_1_11 hd_b_ch2.apph.tab42_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab42_1_1_1_1 hd_h_ch2.apph.tab42_1_1_1_2 hd_h_ch2.apph.tab42_1_1_1_3 hd_h_ch2.apph.tab42_1_1_1_4 hd_h_ch2.apph.tab42_1_1_1_5 hd_h_ch2.apph.tab42_1_1_1_6 hd_h_ch2.apph.tab42_1_1_1_7 hd_h_ch2.apph.tab42_1_1_1_8 hd_h_ch2.apph.tab42_1_1_1_9 hd_h_ch2.apph.tab42_1_1_1_10 hd_h_ch2.apph.tab42_1_1_1_11" id="hd_b_ch2.apph.tab42_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab42_1_1_1_1 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref70" rid="ch2.appo.ref70">Tompson (2017)</a></td><td headers="hd_h_ch2.apph.tab42_1_1_1_2 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab42_1_1_1_3 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">134</td><td headers="hd_h_ch2.apph.tab42_1_1_1_4 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.40</p>
|
|
<p>(0.95, 2.06)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab42_1_1_1_5 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab42_1_1_1_6 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37.31 per 100</td><td headers="hd_h_ch2.apph.tab42_1_1_1_7 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>52.24 per 100</p>
|
|
<p>(35.45, 76.87)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab42_1_1_1_8 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab42_1_1_1_9 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab42_1_1_1_10 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab42_1_1_1_11 hd_b_ch2.apph.tab42_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab42_1_1_1_1 hd_h_ch2.apph.tab42_1_1_1_2 hd_h_ch2.apph.tab42_1_1_1_3 hd_h_ch2.apph.tab42_1_1_1_4 hd_h_ch2.apph.tab42_1_1_1_5 hd_h_ch2.apph.tab42_1_1_1_6 hd_h_ch2.apph.tab42_1_1_1_7 hd_h_ch2.apph.tab42_1_1_1_8 hd_h_ch2.apph.tab42_1_1_1_9 hd_h_ch2.apph.tab42_1_1_1_10 hd_h_ch2.apph.tab42_1_1_1_11" id="hd_b_ch2.apph.tab42_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour family therapy)</th></tr><tr><td headers="hd_h_ch2.apph.tab42_1_1_1_1 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref70" rid="ch2.appo.ref70">Tompson (2017)</a></td><td headers="hd_h_ch2.apph.tab42_1_1_1_2 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab42_1_1_1_3 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">134</td><td headers="hd_h_ch2.apph.tab42_1_1_1_4 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.60</p>
|
|
<p>(0.98, 6.89)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab42_1_1_1_5 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab42_1_1_1_6 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7.46 per 100</td><td headers="hd_h_ch2.apph.tab42_1_1_1_7 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>19.40 per 100</p>
|
|
<p>(7.31, 51.42)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab42_1_1_1_8 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab42_1_1_1_9 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab42_1_1_1_10 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab42_1_1_1_11 hd_b_ch2.apph.tab42_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab42_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab42_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab42_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab43"><div id="ch2.apph.tab43" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab43/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab43_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab43_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab43_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab43_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab43_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab43_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: NDST</th><th id="hd_h_ch2.apph.tab43_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: FB-IPT (95% CI)</th><th id="hd_h_ch2.apph.tab43_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab43_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab43_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab43_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab43_1_1_1_1 hd_h_ch2.apph.tab43_1_1_1_2 hd_h_ch2.apph.tab43_1_1_1_3 hd_h_ch2.apph.tab43_1_1_1_4 hd_h_ch2.apph.tab43_1_1_1_5 hd_h_ch2.apph.tab43_1_1_1_6 hd_h_ch2.apph.tab43_1_1_1_7 hd_h_ch2.apph.tab43_1_1_1_8 hd_h_ch2.apph.tab43_1_1_1_9 hd_h_ch2.apph.tab43_1_1_1_10 hd_h_ch2.apph.tab43_1_1_1_11" id="hd_b_ch2.apph.tab43_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour family based IPT) – Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab43_1_1_1_1 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref18" rid="ch2.appo.ref18">Dietz 2015</a>)</td><td headers="hd_h_ch2.apph.tab43_1_1_1_2 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab43_1_1_1_3 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38</td><td headers="hd_h_ch2.apph.tab43_1_1_1_4 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −4.90</p>
|
|
<p>(−10.76, 0.96)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab43_1_1_1_5 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab43_1_1_1_6 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab43_1_1_1_7 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab43_1_1_1_8 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab43_1_1_1_9 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab43_1_1_1_10 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab43_1_1_1_11 hd_b_ch2.apph.tab43_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab43_1_1_1_1 hd_h_ch2.apph.tab43_1_1_1_2 hd_h_ch2.apph.tab43_1_1_1_3 hd_h_ch2.apph.tab43_1_1_1_4 hd_h_ch2.apph.tab43_1_1_1_5 hd_h_ch2.apph.tab43_1_1_1_6 hd_h_ch2.apph.tab43_1_1_1_7 hd_h_ch2.apph.tab43_1_1_1_8 hd_h_ch2.apph.tab43_1_1_1_9 hd_h_ch2.apph.tab43_1_1_1_10 hd_h_ch2.apph.tab43_1_1_1_11" id="hd_b_ch2.apph.tab43_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour family based IPT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab43_1_1_1_1 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref18" rid="ch2.appo.ref18">Dietz 2015</a>)</td><td headers="hd_h_ch2.apph.tab43_1_1_1_2 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab43_1_1_1_3 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38</td><td headers="hd_h_ch2.apph.tab43_1_1_1_4 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.08</p>
|
|
<p>(0.87, 4.95)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab43_1_1_1_5 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab43_1_1_1_6 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30.77 per 100</td><td headers="hd_h_ch2.apph.tab43_1_1_1_7 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>64.00 per 100</p>
|
|
<p>(26.77, 152.31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab43_1_1_1_8 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab43_1_1_1_9 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab43_1_1_1_10 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab43_1_1_1_11 hd_b_ch2.apph.tab43_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab43_1_1_1_1 hd_h_ch2.apph.tab43_1_1_1_2 hd_h_ch2.apph.tab43_1_1_1_3 hd_h_ch2.apph.tab43_1_1_1_4 hd_h_ch2.apph.tab43_1_1_1_5 hd_h_ch2.apph.tab43_1_1_1_6 hd_h_ch2.apph.tab43_1_1_1_7 hd_h_ch2.apph.tab43_1_1_1_8 hd_h_ch2.apph.tab43_1_1_1_9 hd_h_ch2.apph.tab43_1_1_1_10 hd_h_ch2.apph.tab43_1_1_1_11" id="hd_b_ch2.apph.tab43_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour family based IPT)</th></tr><tr><td headers="hd_h_ch2.apph.tab43_1_1_1_1 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref18" rid="ch2.appo.ref18">Dietz 2015</a>)</td><td headers="hd_h_ch2.apph.tab43_1_1_1_2 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab43_1_1_1_3 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_ch2.apph.tab43_1_1_1_4 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.50</p>
|
|
<p>(0.13, 48.62)</p>
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|
</td><td headers="hd_h_ch2.apph.tab43_1_1_1_5 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab43_1_1_1_6 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-calculable<sup>3</sup></td><td headers="hd_h_ch2.apph.tab43_1_1_1_7 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-calculable<sup>3</sup></td><td headers="hd_h_ch2.apph.tab43_1_1_1_8 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab43_1_1_1_9 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab43_1_1_1_10 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab43_1_1_1_11 hd_b_ch2.apph.tab43_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab43_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab43_2"><p class="no_margin">Study at moderate risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab43_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab43_4"><p class="no_margin">Non calculable as there were zero events in the NDST arm</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab44"><div id="ch2.apph.tab44" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab44/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab44_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab44_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab44_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab44_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab44_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab44_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: family therapy</th><th id="hd_h_ch2.apph.tab44_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: psychodynamic psychotherapy (95% CI)</th><th id="hd_h_ch2.apph.tab44_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab44_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab44_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab44_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_h_ch2.apph.tab44_1_1_1_2 hd_h_ch2.apph.tab44_1_1_1_3 hd_h_ch2.apph.tab44_1_1_1_4 hd_h_ch2.apph.tab44_1_1_1_5 hd_h_ch2.apph.tab44_1_1_1_6 hd_h_ch2.apph.tab44_1_1_1_7 hd_h_ch2.apph.tab44_1_1_1_8 hd_h_ch2.apph.tab44_1_1_1_9 hd_h_ch2.apph.tab44_1_1_1_10 hd_h_ch2.apph.tab44_1_1_1_11" id="hd_b_ch2.apph.tab44_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour psychodynamic psychotherapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell (2007)</a></td><td headers="hd_h_ch2.apph.tab44_1_1_1_2 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab44_1_1_1_3 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab44_1_1_1_4 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.92</p>
|
|
<p>(−5.15, 3.31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_5 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_6 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_7 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_8 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_9 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab44_1_1_1_10 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_11 hd_b_ch2.apph.tab44_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_h_ch2.apph.tab44_1_1_1_2 hd_h_ch2.apph.tab44_1_1_1_3 hd_h_ch2.apph.tab44_1_1_1_4 hd_h_ch2.apph.tab44_1_1_1_5 hd_h_ch2.apph.tab44_1_1_1_6 hd_h_ch2.apph.tab44_1_1_1_7 hd_h_ch2.apph.tab44_1_1_1_8 hd_h_ch2.apph.tab44_1_1_1_9 hd_h_ch2.apph.tab44_1_1_1_10 hd_h_ch2.apph.tab44_1_1_1_11" id="hd_b_ch2.apph.tab44_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour psychodynamic psychotherapy) – ≤6months</th></tr><tr><td headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell (2007)</a></td><td headers="hd_h_ch2.apph.tab44_1_1_1_2 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab44_1_1_1_3 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab44_1_1_1_4 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 0.89</p>
|
|
<p>(−2.94, 4.72)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_5 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_6 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_7 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_8 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_9 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab44_1_1_1_10 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_11 hd_b_ch2.apph.tab44_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_h_ch2.apph.tab44_1_1_1_2 hd_h_ch2.apph.tab44_1_1_1_3 hd_h_ch2.apph.tab44_1_1_1_4 hd_h_ch2.apph.tab44_1_1_1_5 hd_h_ch2.apph.tab44_1_1_1_6 hd_h_ch2.apph.tab44_1_1_1_7 hd_h_ch2.apph.tab44_1_1_1_8 hd_h_ch2.apph.tab44_1_1_1_9 hd_h_ch2.apph.tab44_1_1_1_10 hd_h_ch2.apph.tab44_1_1_1_11" id="hd_b_ch2.apph.tab44_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour psychodynamic psychotherapy) – Post treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell (2007)</a></td><td headers="hd_h_ch2.apph.tab44_1_1_1_2 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab44_1_1_1_3 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab44_1_1_1_4 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 5.20</p>
|
|
<p>(1.45, 8.95)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_5 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_6 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_7 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_8 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_9 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab44_1_1_1_10 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_11 hd_b_ch2.apph.tab44_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_h_ch2.apph.tab44_1_1_1_2 hd_h_ch2.apph.tab44_1_1_1_3 hd_h_ch2.apph.tab44_1_1_1_4 hd_h_ch2.apph.tab44_1_1_1_5 hd_h_ch2.apph.tab44_1_1_1_6 hd_h_ch2.apph.tab44_1_1_1_7 hd_h_ch2.apph.tab44_1_1_1_8 hd_h_ch2.apph.tab44_1_1_1_9 hd_h_ch2.apph.tab44_1_1_1_10 hd_h_ch2.apph.tab44_1_1_1_11" id="hd_b_ch2.apph.tab44_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour psychodynamic psychotherapy) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell (2007)</a></td><td headers="hd_h_ch2.apph.tab44_1_1_1_2 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab44_1_1_1_3 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab44_1_1_1_4 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 1.40</p>
|
|
<p>(−1.94, 4.74)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_5 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_6 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_7 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_8 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_9 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab44_1_1_1_10 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_11 hd_b_ch2.apph.tab44_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_h_ch2.apph.tab44_1_1_1_2 hd_h_ch2.apph.tab44_1_1_1_3 hd_h_ch2.apph.tab44_1_1_1_4 hd_h_ch2.apph.tab44_1_1_1_5 hd_h_ch2.apph.tab44_1_1_1_6 hd_h_ch2.apph.tab44_1_1_1_7 hd_h_ch2.apph.tab44_1_1_1_8 hd_h_ch2.apph.tab44_1_1_1_9 hd_h_ch2.apph.tab44_1_1_1_10 hd_h_ch2.apph.tab44_1_1_1_11" id="hd_b_ch2.apph.tab44_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour psychodynamic psychotherapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell (2007)</a></td><td headers="hd_h_ch2.apph.tab44_1_1_1_2 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab44_1_1_1_3 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab44_1_1_1_4 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.98</p>
|
|
<p>(0.75, 1.28)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_5 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_6 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76 per 100</td><td headers="hd_h_ch2.apph.tab44_1_1_1_7 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>74 per 100</p>
|
|
<p>(57, 97)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_8 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_9 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab44_1_1_1_10 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_11 hd_b_ch2.apph.tab44_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_h_ch2.apph.tab44_1_1_1_2 hd_h_ch2.apph.tab44_1_1_1_3 hd_h_ch2.apph.tab44_1_1_1_4 hd_h_ch2.apph.tab44_1_1_1_5 hd_h_ch2.apph.tab44_1_1_1_6 hd_h_ch2.apph.tab44_1_1_1_7 hd_h_ch2.apph.tab44_1_1_1_8 hd_h_ch2.apph.tab44_1_1_1_9 hd_h_ch2.apph.tab44_1_1_1_10 hd_h_ch2.apph.tab44_1_1_1_11" id="hd_b_ch2.apph.tab44_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour psychodynamic psychotherapy) – ≤6months</th></tr><tr><td headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell (2007)</a></td><td headers="hd_h_ch2.apph.tab44_1_1_1_2 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab44_1_1_1_3 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab44_1_1_1_4 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.23</p>
|
|
<p>(1.04, 1.45)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_5 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_6 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81 per 100</td><td headers="hd_h_ch2.apph.tab44_1_1_1_7 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>99 per 100</p>
|
|
<p>(84, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_8 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_9 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab44_1_1_1_10 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_11 hd_b_ch2.apph.tab44_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_h_ch2.apph.tab44_1_1_1_2 hd_h_ch2.apph.tab44_1_1_1_3 hd_h_ch2.apph.tab44_1_1_1_4 hd_h_ch2.apph.tab44_1_1_1_5 hd_h_ch2.apph.tab44_1_1_1_6 hd_h_ch2.apph.tab44_1_1_1_7 hd_h_ch2.apph.tab44_1_1_1_8 hd_h_ch2.apph.tab44_1_1_1_9 hd_h_ch2.apph.tab44_1_1_1_10 hd_h_ch2.apph.tab44_1_1_1_11" id="hd_b_ch2.apph.tab44_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour psychodynamic psychotherapy)</th></tr><tr><td headers="hd_h_ch2.apph.tab44_1_1_1_1 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell (2007)</a></td><td headers="hd_h_ch2.apph.tab44_1_1_1_2 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab44_1_1_1_3 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab44_1_1_1_4 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.12</p>
|
|
<p>(0.01, 2.10)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab44_1_1_1_5 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab44_1_1_1_6 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11 per 100</td><td headers="hd_h_ch2.apph.tab44_1_1_1_7 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 per 100 (0, 23)</td><td headers="hd_h_ch2.apph.tab44_1_1_1_8 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_9 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab44_1_1_1_10 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab44_1_1_1_11 hd_b_ch2.apph.tab44_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab44_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab44_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab45"><div id="ch2.apph.tab45" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab45/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab45_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab45_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab45_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab45_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab45_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab45_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab45_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab45_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab45_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab45_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab45_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab45_1_1_1_1 hd_h_ch2.apph.tab45_1_1_1_2 hd_h_ch2.apph.tab45_1_1_1_3 hd_h_ch2.apph.tab45_1_1_1_4 hd_h_ch2.apph.tab45_1_1_1_5 hd_h_ch2.apph.tab45_1_1_1_6 hd_h_ch2.apph.tab45_1_1_1_7 hd_h_ch2.apph.tab45_1_1_1_8 hd_h_ch2.apph.tab45_1_1_1_9 hd_h_ch2.apph.tab45_1_1_1_10 hd_h_ch2.apph.tab45_1_1_1_11" id="hd_b_ch2.apph.tab45_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab45_1_1_1_1 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref3" rid="ch2.appo.ref3">Alavi 2013</a>, <a class="bibr" href="#ch2.appo.ref9" rid="ch2.appo.ref9">Charkhandeh 2016</a>, <a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rosello 1999</a>)</td><td headers="hd_h_ch2.apph.tab45_1_1_1_2 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab45_1_1_1_3 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">194</td><td headers="hd_h_ch2.apph.tab45_1_1_1_4 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −1.77</p>
|
|
<p>(−3.13, −0.41)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab45_1_1_1_5 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−15.34</p>
|
|
<p>(−27.13, −3.55)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab45_1_1_1_6 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab45_1_1_1_7 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab45_1_1_1_8 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab45_1_1_1_9 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab45_1_1_1_10 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab45_1_1_1_11 hd_b_ch2.apph.tab45_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab45_1_1_1_1 hd_h_ch2.apph.tab45_1_1_1_2 hd_h_ch2.apph.tab45_1_1_1_3 hd_h_ch2.apph.tab45_1_1_1_4 hd_h_ch2.apph.tab45_1_1_1_5 hd_h_ch2.apph.tab45_1_1_1_6 hd_h_ch2.apph.tab45_1_1_1_7 hd_h_ch2.apph.tab45_1_1_1_8 hd_h_ch2.apph.tab45_1_1_1_9 hd_h_ch2.apph.tab45_1_1_1_10 hd_h_ch2.apph.tab45_1_1_1_11" id="hd_b_ch2.apph.tab45_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, SSI (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab45_1_1_1_1 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref3" rid="ch2.appo.ref3">Alavi 2013</a>)</td><td headers="hd_h_ch2.apph.tab45_1_1_1_2 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab45_1_1_1_3 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch2.apph.tab45_1_1_1_4 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −17.00</p>
|
|
<p>(−20.35, −13.65)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab45_1_1_1_5 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab45_1_1_1_6 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab45_1_1_1_7 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab45_1_1_1_8 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab45_1_1_1_9 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab45_1_1_1_10 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab45_1_1_1_11 hd_b_ch2.apph.tab45_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab45_1_1_1_1 hd_h_ch2.apph.tab45_1_1_1_2 hd_h_ch2.apph.tab45_1_1_1_3 hd_h_ch2.apph.tab45_1_1_1_4 hd_h_ch2.apph.tab45_1_1_1_5 hd_h_ch2.apph.tab45_1_1_1_6 hd_h_ch2.apph.tab45_1_1_1_7 hd_h_ch2.apph.tab45_1_1_1_8 hd_h_ch2.apph.tab45_1_1_1_9 hd_h_ch2.apph.tab45_1_1_1_10 hd_h_ch2.apph.tab45_1_1_1_11" id="hd_b_ch2.apph.tab45_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab45_1_1_1_1 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rosello 1999</a>)</td><td headers="hd_h_ch2.apph.tab45_1_1_1_2 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab45_1_1_1_3 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch2.apph.tab45_1_1_1_4 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.74</p>
|
|
<p>(0.22, 2.41)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab45_1_1_1_5 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab45_1_1_1_6 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22 per 100</td><td headers="hd_h_ch2.apph.tab45_1_1_1_7 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>16 per 100</p>
|
|
<p>(5, 52)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab45_1_1_1_8 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab45_1_1_1_9 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab45_1_1_1_10 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>3</sup></td><td headers="hd_h_ch2.apph.tab45_1_1_1_11 hd_b_ch2.apph.tab45_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab45_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab45_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab45_3"><p class="no_margin">I<sup>2</sup> >66.7%</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab45_4"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab46"><div id="ch2.apph.tab46" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab46/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab46_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab46_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab46_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab46_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab46_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab46_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab46_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab46_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab46_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab46_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab46_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_h_ch2.apph.tab46_1_1_1_2 hd_h_ch2.apph.tab46_1_1_1_3 hd_h_ch2.apph.tab46_1_1_1_4 hd_h_ch2.apph.tab46_1_1_1_5 hd_h_ch2.apph.tab46_1_1_1_6 hd_h_ch2.apph.tab46_1_1_1_7 hd_h_ch2.apph.tab46_1_1_1_8 hd_h_ch2.apph.tab46_1_1_1_9 hd_h_ch2.apph.tab46_1_1_1_10 hd_h_ch2.apph.tab46_1_1_1_11" id="hd_b_ch2.apph.tab46_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March/TADS 2004</a>)</td><td headers="hd_h_ch2.apph.tab46_1_1_1_2 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab46_1_1_1_3 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">223</td><td headers="hd_h_ch2.apph.tab46_1_1_1_4 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>MD −0.20</p>
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<p>(−2.98, 2.58)</p>
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</td><td headers="hd_h_ch2.apph.tab46_1_1_1_5 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_6 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_7 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_8 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_9 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab46_1_1_1_10 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_11 hd_b_ch2.apph.tab46_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_h_ch2.apph.tab46_1_1_1_2 hd_h_ch2.apph.tab46_1_1_1_3 hd_h_ch2.apph.tab46_1_1_1_4 hd_h_ch2.apph.tab46_1_1_1_5 hd_h_ch2.apph.tab46_1_1_1_6 hd_h_ch2.apph.tab46_1_1_1_7 hd_h_ch2.apph.tab46_1_1_1_8 hd_h_ch2.apph.tab46_1_1_1_9 hd_h_ch2.apph.tab46_1_1_1_10 hd_h_ch2.apph.tab46_1_1_1_11" id="hd_b_ch2.apph.tab46_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS-R (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March/TADS 2004</a>)</td><td headers="hd_h_ch2.apph.tab46_1_1_1_2 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab46_1_1_1_3 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">223</td><td headers="hd_h_ch2.apph.tab46_1_1_1_4 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD 0.24</p>
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<p>(−0.02, 0.51)</p>
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</td><td headers="hd_h_ch2.apph.tab46_1_1_1_5 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup> CDI scale</p>
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<p>2.08</p>
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<p>(−0.17, 4.42)</p>
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</td><td headers="hd_h_ch2.apph.tab46_1_1_1_6 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_7 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_8 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_9 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab46_1_1_1_10 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_11 hd_b_ch2.apph.tab46_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_h_ch2.apph.tab46_1_1_1_2 hd_h_ch2.apph.tab46_1_1_1_3 hd_h_ch2.apph.tab46_1_1_1_4 hd_h_ch2.apph.tab46_1_1_1_5 hd_h_ch2.apph.tab46_1_1_1_6 hd_h_ch2.apph.tab46_1_1_1_7 hd_h_ch2.apph.tab46_1_1_1_8 hd_h_ch2.apph.tab46_1_1_1_9 hd_h_ch2.apph.tab46_1_1_1_10 hd_h_ch2.apph.tab46_1_1_1_11" id="hd_b_ch2.apph.tab46_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, HoNOSCA (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March/TADS 2004</a>)</td><td headers="hd_h_ch2.apph.tab46_1_1_1_2 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab46_1_1_1_3 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">163</td><td headers="hd_h_ch2.apph.tab46_1_1_1_4 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>MD 0.90</p>
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<p>(−0.90, 2.70)</p>
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</td><td headers="hd_h_ch2.apph.tab46_1_1_1_5 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_6 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_7 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_8 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_9 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab46_1_1_1_10 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_11 hd_b_ch2.apph.tab46_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_h_ch2.apph.tab46_1_1_1_2 hd_h_ch2.apph.tab46_1_1_1_3 hd_h_ch2.apph.tab46_1_1_1_4 hd_h_ch2.apph.tab46_1_1_1_5 hd_h_ch2.apph.tab46_1_1_1_6 hd_h_ch2.apph.tab46_1_1_1_7 hd_h_ch2.apph.tab46_1_1_1_8 hd_h_ch2.apph.tab46_1_1_1_9 hd_h_ch2.apph.tab46_1_1_1_10 hd_h_ch2.apph.tab46_1_1_1_11" id="hd_b_ch2.apph.tab46_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide-related adverse events (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March/TADS 2004</a>)</td><td headers="hd_h_ch2.apph.tab46_1_1_1_2 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab46_1_1_1_3 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">123</td><td headers="hd_h_ch2.apph.tab46_1_1_1_4 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>RR 1.26</p>
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<p>(0.35, 4.57)</p>
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</td><td headers="hd_h_ch2.apph.tab46_1_1_1_5 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_6 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4 per 100</td><td headers="hd_h_ch2.apph.tab46_1_1_1_7 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>5 per 100</p>
|
|
<p>(1, 16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab46_1_1_1_8 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_9 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab46_1_1_1_10 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_11 hd_b_ch2.apph.tab46_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_h_ch2.apph.tab46_1_1_1_2 hd_h_ch2.apph.tab46_1_1_1_3 hd_h_ch2.apph.tab46_1_1_1_4 hd_h_ch2.apph.tab46_1_1_1_5 hd_h_ch2.apph.tab46_1_1_1_6 hd_h_ch2.apph.tab46_1_1_1_7 hd_h_ch2.apph.tab46_1_1_1_8 hd_h_ch2.apph.tab46_1_1_1_9 hd_h_ch2.apph.tab46_1_1_1_10 hd_h_ch2.apph.tab46_1_1_1_11" id="hd_b_ch2.apph.tab46_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, SIQ-JR (values lower than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March/TADS 2004</a>)</td><td headers="hd_h_ch2.apph.tab46_1_1_1_2 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab46_1_1_1_3 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">123</td><td headers="hd_h_ch2.apph.tab46_1_1_1_4 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>MD −1.32</p>
|
|
<p>(−5.10, 2.46)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab46_1_1_1_5 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_6 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_7 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_8 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_9 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab46_1_1_1_10 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_11 hd_b_ch2.apph.tab46_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_h_ch2.apph.tab46_1_1_1_2 hd_h_ch2.apph.tab46_1_1_1_3 hd_h_ch2.apph.tab46_1_1_1_4 hd_h_ch2.apph.tab46_1_1_1_5 hd_h_ch2.apph.tab46_1_1_1_6 hd_h_ch2.apph.tab46_1_1_1_7 hd_h_ch2.apph.tab46_1_1_1_8 hd_h_ch2.apph.tab46_1_1_1_9 hd_h_ch2.apph.tab46_1_1_1_10 hd_h_ch2.apph.tab46_1_1_1_11" id="hd_b_ch2.apph.tab46_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation (values lower than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March/TADS 2004</a>)</td><td headers="hd_h_ch2.apph.tab46_1_1_1_2 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab46_1_1_1_3 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">123</td><td headers="hd_h_ch2.apph.tab46_1_1_1_4 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>RR 1.35</p>
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<p>(0.31, 5.87)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab46_1_1_1_5 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_6 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 per 100</td><td headers="hd_h_ch2.apph.tab46_1_1_1_7 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>4 per 100</p>
|
|
<p>(1, 16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab46_1_1_1_8 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_9 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab46_1_1_1_10 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_11 hd_b_ch2.apph.tab46_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_h_ch2.apph.tab46_1_1_1_2 hd_h_ch2.apph.tab46_1_1_1_3 hd_h_ch2.apph.tab46_1_1_1_4 hd_h_ch2.apph.tab46_1_1_1_5 hd_h_ch2.apph.tab46_1_1_1_6 hd_h_ch2.apph.tab46_1_1_1_7 hd_h_ch2.apph.tab46_1_1_1_8 hd_h_ch2.apph.tab46_1_1_1_9 hd_h_ch2.apph.tab46_1_1_1_10 hd_h_ch2.apph.tab46_1_1_1_11" id="hd_b_ch2.apph.tab46_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab46_1_1_1_1 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March/TADS 2004</a>)</td><td headers="hd_h_ch2.apph.tab46_1_1_1_2 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab46_1_1_1_3 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">123</td><td headers="hd_h_ch2.apph.tab46_1_1_1_4 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.05</p>
|
|
<p>(0.63, 1.75)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab46_1_1_1_5 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab46_1_1_1_6 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21 per 100</td><td headers="hd_h_ch2.apph.tab46_1_1_1_7 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>22 per 100</p>
|
|
<p>(13, 36)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab46_1_1_1_8 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_9 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab46_1_1_1_10 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab46_1_1_1_11 hd_b_ch2.apph.tab46_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab46_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab46_2"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab46_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab47"><div id="ch2.apph.tab47" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab47/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab47_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab47_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab47_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab47_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab47_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab47_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab47_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab47_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab47_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab47_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab47_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 4.27</p>
|
|
<p>(1.99, 6.55)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 1.84</p>
|
|
<p>(−0.49, 4.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.03</p>
|
|
<p>(−2.62, 2.56)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>, <a class="bibr" href="#ch2.appo.ref39" rid="ch2.appo.ref39">Kobak 2015</a>, Shirk 2013)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">220</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.13</p>
|
|
<p>(−0.61, 0.34)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.13</p>
|
|
<p>(−5.29, 2.95)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS-R (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.11</p>
|
|
<p>(−0.38, 0.16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.95</p>
|
|
<p>(−3.29, 1.39)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS-R (values lower than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.14</p>
|
|
<p>(−0.41, 0.13)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.21</p>
|
|
<p>(−3.55, 1.13)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (Shirk 2013)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.05</p>
|
|
<p>(0.57, 1.93)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47.8 per 100</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>50.22 per 100</p>
|
|
<p>(27.3, 92.3)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_15_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, PEDS-QL (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.44</p>
|
|
<p>(−0.71, −0.17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>***</sup>HoNOSCA scale</p>
|
|
<p>−2.85</p>
|
|
<p>(−4.6, −1.1)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_17_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, PEDS-QL (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.29</p>
|
|
<p>(−0.56, −0.02)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>***</sup>HoNOSCA scale</p>
|
|
<p>−1.88</p>
|
|
<p>(−3.63, −0.13)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_19_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, PEDS-QL (values lower than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.01</p>
|
|
<p>(−0.28, 0.26)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>***</sup>HoNOSCA scale</p>
|
|
<p>−0.06</p>
|
|
<p>(−1.81, 1.68)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_21_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, KSAD suicide behaviour (values lower than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.20</p>
|
|
<p>(0.04, 0.89)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 per 100</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2 per 100</p>
|
|
<p>(0, 8)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_23_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, KSAD suicide behaviour (values lower than 1 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.50</p>
|
|
<p>(0.05, 5.43)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 per 100</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>1 per 100</p>
|
|
<p>(0, 10)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_25_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, KSAD suicide behaviour (values lower than 1 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">212</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.67</p>
|
|
<p>(0.11, 3.91)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 per 100</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>2 per 100</p>
|
|
<p>(0, 11)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_h_ch2.apph.tab47_1_1_1_2 hd_h_ch2.apph.tab47_1_1_1_3 hd_h_ch2.apph.tab47_1_1_1_4 hd_h_ch2.apph.tab47_1_1_1_5 hd_h_ch2.apph.tab47_1_1_1_6 hd_h_ch2.apph.tab47_1_1_1_7 hd_h_ch2.apph.tab47_1_1_1_8 hd_h_ch2.apph.tab47_1_1_1_9 hd_h_ch2.apph.tab47_1_1_1_10 hd_h_ch2.apph.tab47_1_1_1_11" id="hd_b_ch2.apph.tab47_1_1_27_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab47_1_1_1_1 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>, <a class="bibr" href="#ch2.appo.ref39" rid="ch2.appo.ref39">Kobak 2015</a>, Shirk 2013)</td><td headers="hd_h_ch2.apph.tab47_1_1_1_2 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab47_1_1_1_3 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">321</td><td headers="hd_h_ch2.apph.tab47_1_1_1_4 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.62</p>
|
|
<p>(0.33, 1.16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_5 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab47_1_1_1_6 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 per 100</td><td headers="hd_h_ch2.apph.tab47_1_1_1_7 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>8.7 per 100</p>
|
|
<p>(4.6, 16.3)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab47_1_1_1_8 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab47_1_1_1_9 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_10 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab47_1_1_1_11 hd_b_ch2.apph.tab47_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab47_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>***</dt><dd><div id="ch2.apph.tab47_2"><p class="no_margin">SMD to MD conversion on HoNOSCA scale using pooled SD for all studies using this scale (6.4787)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab47_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab47_4"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab47_5"><p class="no_margin">I<sup>2</sup> >66.7%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab48"><div id="ch2.apph.tab48" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab48/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab48_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab48_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab48_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab48_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab48_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab48_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab48_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab48_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab48_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab48_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab48_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab48_1_1_1_1 hd_h_ch2.apph.tab48_1_1_1_2 hd_h_ch2.apph.tab48_1_1_1_3 hd_h_ch2.apph.tab48_1_1_1_4 hd_h_ch2.apph.tab48_1_1_1_5 hd_h_ch2.apph.tab48_1_1_1_6 hd_h_ch2.apph.tab48_1_1_1_7 hd_h_ch2.apph.tab48_1_1_1_8 hd_h_ch2.apph.tab48_1_1_1_9 hd_h_ch2.apph.tab48_1_1_1_10 hd_h_ch2.apph.tab48_1_1_1_11" id="hd_b_ch2.apph.tab48_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab48_1_1_1_1 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>, Shirk 2013)</td><td headers="hd_h_ch2.apph.tab48_1_1_1_2 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab48_1_1_1_3 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">255</td><td headers="hd_h_ch2.apph.tab48_1_1_1_4 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.11</p>
|
|
<p>(−0.92, 0.69)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab48_1_1_1_5 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.95</p>
|
|
<p>(−7.97, 5.98)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab48_1_1_1_6 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab48_1_1_1_7 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab48_1_1_1_8 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab48_1_1_1_9 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab48_1_1_1_10 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab48_1_1_1_11 hd_b_ch2.apph.tab48_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab48_1_1_1_1 hd_h_ch2.apph.tab48_1_1_1_2 hd_h_ch2.apph.tab48_1_1_1_3 hd_h_ch2.apph.tab48_1_1_1_4 hd_h_ch2.apph.tab48_1_1_1_5 hd_h_ch2.apph.tab48_1_1_1_6 hd_h_ch2.apph.tab48_1_1_1_7 hd_h_ch2.apph.tab48_1_1_1_8 hd_h_ch2.apph.tab48_1_1_1_9 hd_h_ch2.apph.tab48_1_1_1_10 hd_h_ch2.apph.tab48_1_1_1_11" id="hd_b_ch2.apph.tab48_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab48_1_1_1_1 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke 2016</a>, Shirk 2013)</td><td headers="hd_h_ch2.apph.tab48_1_1_1_2 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab48_1_1_1_3 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">245</td><td headers="hd_h_ch2.apph.tab48_1_1_1_4 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>RR 0.66</p>
|
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<p>(0.31, 1.40)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab48_1_1_1_5 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab48_1_1_1_6 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12.60 per 100</td><td headers="hd_h_ch2.apph.tab48_1_1_1_7 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>8.31 per 100</p>
|
|
<p>(3.91, 17.64)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab48_1_1_1_8 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab48_1_1_1_9 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab48_1_1_1_10 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab48_1_1_1_11 hd_b_ch2.apph.tab48_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab48_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab48_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab48_3"><p class="no_margin">I<sup>2</sup> >66.7%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab49"><div id="ch2.apph.tab49" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab49/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab49_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab49_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab49_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab49_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab49_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab49_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: family therapy</th><th id="hd_h_ch2.apph.tab49_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: CBT (95% CI)</th><th id="hd_h_ch2.apph.tab49_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab49_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab49_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab49_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_h_ch2.apph.tab49_1_1_1_2 hd_h_ch2.apph.tab49_1_1_1_3 hd_h_ch2.apph.tab49_1_1_1_4 hd_h_ch2.apph.tab49_1_1_1_5 hd_h_ch2.apph.tab49_1_1_1_6 hd_h_ch2.apph.tab49_1_1_1_7 hd_h_ch2.apph.tab49_1_1_1_8 hd_h_ch2.apph.tab49_1_1_1_9 hd_h_ch2.apph.tab49_1_1_1_10 hd_h_ch2.apph.tab49_1_1_1_11" id="hd_b_ch2.apph.tab49_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab49_1_1_1_2 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab49_1_1_1_3 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66</td><td headers="hd_h_ch2.apph.tab49_1_1_1_4 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −2.40</p>
|
|
<p>(−6.61, 1.81)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab49_1_1_1_5 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab49_1_1_1_6 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab49_1_1_1_7 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab49_1_1_1_8 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_9 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab49_1_1_1_10 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_11 hd_b_ch2.apph.tab49_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_h_ch2.apph.tab49_1_1_1_2 hd_h_ch2.apph.tab49_1_1_1_3 hd_h_ch2.apph.tab49_1_1_1_4 hd_h_ch2.apph.tab49_1_1_1_5 hd_h_ch2.apph.tab49_1_1_1_6 hd_h_ch2.apph.tab49_1_1_1_7 hd_h_ch2.apph.tab49_1_1_1_8 hd_h_ch2.apph.tab49_1_1_1_9 hd_h_ch2.apph.tab49_1_1_1_10 hd_h_ch2.apph.tab49_1_1_1_11" id="hd_b_ch2.apph.tab49_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab49_1_1_1_2 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab49_1_1_1_3 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_ch2.apph.tab49_1_1_1_4 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.59</p>
|
|
<p>(−1.10, −0.09)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab49_1_1_1_5 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
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<p>−5.11</p>
|
|
<p>(−9.53, −0.78)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab49_1_1_1_6 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab49_1_1_1_7 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab49_1_1_1_8 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_9 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab49_1_1_1_10 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_11 hd_b_ch2.apph.tab49_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_h_ch2.apph.tab49_1_1_1_2 hd_h_ch2.apph.tab49_1_1_1_3 hd_h_ch2.apph.tab49_1_1_1_4 hd_h_ch2.apph.tab49_1_1_1_5 hd_h_ch2.apph.tab49_1_1_1_6 hd_h_ch2.apph.tab49_1_1_1_7 hd_h_ch2.apph.tab49_1_1_1_8 hd_h_ch2.apph.tab49_1_1_1_9 hd_h_ch2.apph.tab49_1_1_1_10 hd_h_ch2.apph.tab49_1_1_1_11" id="hd_b_ch2.apph.tab49_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab49_1_1_1_2 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab49_1_1_1_3 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66</td><td headers="hd_h_ch2.apph.tab49_1_1_1_4 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.07</p>
|
|
<p>(1.12, 3.82)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab49_1_1_1_5 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab49_1_1_1_6 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29 per 100</td><td headers="hd_h_ch2.apph.tab49_1_1_1_7 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>60 per 100</p>
|
|
<p>(33, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab49_1_1_1_8 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_9 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab49_1_1_1_10 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_11 hd_b_ch2.apph.tab49_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_h_ch2.apph.tab49_1_1_1_2 hd_h_ch2.apph.tab49_1_1_1_3 hd_h_ch2.apph.tab49_1_1_1_4 hd_h_ch2.apph.tab49_1_1_1_5 hd_h_ch2.apph.tab49_1_1_1_6 hd_h_ch2.apph.tab49_1_1_1_7 hd_h_ch2.apph.tab49_1_1_1_8 hd_h_ch2.apph.tab49_1_1_1_9 hd_h_ch2.apph.tab49_1_1_1_10 hd_h_ch2.apph.tab49_1_1_1_11" id="hd_b_ch2.apph.tab49_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, K-SADS-P/E score >4 (values lower than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab49_1_1_1_2 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab49_1_1_1_3 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66</td><td headers="hd_h_ch2.apph.tab49_1_1_1_4 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.33</p>
|
|
<p>(0.24, 7.44)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab49_1_1_1_5 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab49_1_1_1_6 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6 per 100</td><td headers="hd_h_ch2.apph.tab49_1_1_1_7 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>9 per 100</p>
|
|
<p>(2, 48)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab49_1_1_1_8 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_9 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab49_1_1_1_10 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_11 hd_b_ch2.apph.tab49_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_h_ch2.apph.tab49_1_1_1_2 hd_h_ch2.apph.tab49_1_1_1_3 hd_h_ch2.apph.tab49_1_1_1_4 hd_h_ch2.apph.tab49_1_1_1_5 hd_h_ch2.apph.tab49_1_1_1_6 hd_h_ch2.apph.tab49_1_1_1_7 hd_h_ch2.apph.tab49_1_1_1_8 hd_h_ch2.apph.tab49_1_1_1_9 hd_h_ch2.apph.tab49_1_1_1_10 hd_h_ch2.apph.tab49_1_1_1_11" id="hd_b_ch2.apph.tab49_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab49_1_1_1_1 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab49_1_1_1_2 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab49_1_1_1_3 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_ch2.apph.tab49_1_1_1_4 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>RR 1.42</p>
|
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<p>(0.25, 7.99)</p>
|
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</td><td headers="hd_h_ch2.apph.tab49_1_1_1_5 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab49_1_1_1_6 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6 per 100</td><td headers="hd_h_ch2.apph.tab49_1_1_1_7 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>8 per 100</p>
|
|
<p>(1, 46)</p>
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|
</td><td headers="hd_h_ch2.apph.tab49_1_1_1_8 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_9 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab49_1_1_1_10 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab49_1_1_1_11 hd_b_ch2.apph.tab49_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab49_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab49_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab49_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab50"><div id="ch2.apph.tab50" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab50/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab50_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab50_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab50_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab50_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab50_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab50_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: NDST</th><th id="hd_h_ch2.apph.tab50_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: CBT (95% CI)</th><th id="hd_h_ch2.apph.tab50_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab50_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab50_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab50_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>MD 0.40</p>
|
|
<p>(−4.85, 4.05)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.29</p>
|
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<p>(−0.77, 0.19)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
|
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<p>−2.51</p>
|
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<p>(−6.67, 1.65)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Main analysis: Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>, <a class="bibr" href="#ch2.appo.ref22" rid="ch2.appo.ref22">Feehan 1996</a>, <a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy 2014</a>, <a class="bibr" href="#ch2.appo.ref75" rid="ch2.appo.ref75">Vostanis 1996</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">398</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.14</p>
|
|
<p>(0.99, 1.31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.24 per 100</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>70.96 per 100</p>
|
|
<p>(61.62, 81.54)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup analysis: With comorbidity (IBS), Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy 2014</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">217</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.04</p>
|
|
<p>(0.86, 1.27)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63.55 per 100</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>66.09 per 100</p>
|
|
<p>(54.65, 80.71)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup analysis: Without comorbidity, Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>, <a class="bibr" href="#ch2.appo.ref22" rid="ch2.appo.ref22">Feehan 1996</a>, <a class="bibr" href="#ch2.appo.ref75" rid="ch2.appo.ref75">Vostanis 1996</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">124</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.26</p>
|
|
<p>(1.04, 1.53)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61 per 100</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>76 per 100</p>
|
|
<p>(63, 93)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref75" rid="ch2.appo.ref75">Vostanis 1996</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.95</p>
|
|
<p>(0.69, 1.31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75 per 100</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>71 per 100</p>
|
|
<p>(52, 98)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, K-SADS-P/E score >4 (values lower than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.57</p>
|
|
<p>(0.15, 2.18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 per 100</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>9 per 100</p>
|
|
<p>(2, 33)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_15_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Main analysis: Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>, <a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy 2014</a>, <a class="bibr" href="#ch2.appo.ref75" rid="ch2.appo.ref75">Vostanis 1996</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">319</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.89</p>
|
|
<p>(0.53, 1.49)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15.13 per 100</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>13.47 per 100</p>
|
|
<p>(8.02, 22.55)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_17_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup analysis: With comorbidity (IBS), Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy 2014</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">191</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.92</p>
|
|
<p>(0.52, 1.61)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21.35 per 100</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>19.64 per 100</p>
|
|
<p>(11.10, 34.37)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_h_ch2.apph.tab50_1_1_1_2 hd_h_ch2.apph.tab50_1_1_1_3 hd_h_ch2.apph.tab50_1_1_1_4 hd_h_ch2.apph.tab50_1_1_1_5 hd_h_ch2.apph.tab50_1_1_1_6 hd_h_ch2.apph.tab50_1_1_1_7 hd_h_ch2.apph.tab50_1_1_1_8 hd_h_ch2.apph.tab50_1_1_1_9 hd_h_ch2.apph.tab50_1_1_1_10 hd_h_ch2.apph.tab50_1_1_1_11" id="hd_b_ch2.apph.tab50_1_1_19_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Subgroup analysis: Without comorbidity, Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab50_1_1_1_1 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>, <a class="bibr" href="#ch2.appo.ref75" rid="ch2.appo.ref75">Vostanis 1996</a>)</td><td headers="hd_h_ch2.apph.tab50_1_1_1_2 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab50_1_1_1_3 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">128</td><td headers="hd_h_ch2.apph.tab50_1_1_1_4 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.75</p>
|
|
<p>(0.19, 2.88)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_5 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab50_1_1_1_6 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6 per 100</td><td headers="hd_h_ch2.apph.tab50_1_1_1_7 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>5 per 100</p>
|
|
<p>(1, 18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab50_1_1_1_8 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab50_1_1_1_9 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_10 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab50_1_1_1_11 hd_b_ch2.apph.tab50_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab50_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">IBS: irritable bowel syndrome</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab50_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab50_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab51"><div id="ch2.apph.tab51" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab51/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab51_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab51_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab51_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab51_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab51_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab51_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: psychodynamic psychotherapy</th><th id="hd_h_ch2.apph.tab51_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: CBT (95% CI)</th><th id="hd_h_ch2.apph.tab51_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab51_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab51_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab51_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_h_ch2.apph.tab51_1_1_1_2 hd_h_ch2.apph.tab51_1_1_1_3 hd_h_ch2.apph.tab51_1_1_1_4 hd_h_ch2.apph.tab51_1_1_1_5 hd_h_ch2.apph.tab51_1_1_1_6 hd_h_ch2.apph.tab51_1_1_1_7 hd_h_ch2.apph.tab51_1_1_1_8 hd_h_ch2.apph.tab51_1_1_1_9 hd_h_ch2.apph.tab51_1_1_1_10 hd_h_ch2.apph.tab51_1_1_1_11" id="hd_b_ch2.apph.tab51_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab51_1_1_1_2 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab51_1_1_1_3 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">213</td><td headers="hd_h_ch2.apph.tab51_1_1_1_4 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.23</p>
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<p>(−0.50, 0.04)</p>
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</td><td headers="hd_h_ch2.apph.tab51_1_1_1_5 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−1.99</p>
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<p>(−4.33, 0.35)</p>
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</td><td headers="hd_h_ch2.apph.tab51_1_1_1_6 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_7 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_8 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_9 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_10 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab51_1_1_1_11 hd_b_ch2.apph.tab51_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_h_ch2.apph.tab51_1_1_1_2 hd_h_ch2.apph.tab51_1_1_1_3 hd_h_ch2.apph.tab51_1_1_1_4 hd_h_ch2.apph.tab51_1_1_1_5 hd_h_ch2.apph.tab51_1_1_1_6 hd_h_ch2.apph.tab51_1_1_1_7 hd_h_ch2.apph.tab51_1_1_1_8 hd_h_ch2.apph.tab51_1_1_1_9 hd_h_ch2.apph.tab51_1_1_1_10 hd_h_ch2.apph.tab51_1_1_1_11" id="hd_b_ch2.apph.tab51_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab51_1_1_1_2 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab51_1_1_1_3 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">221</td><td headers="hd_h_ch2.apph.tab51_1_1_1_4 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD 0.08</p>
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<p>(−0.18, 0.34)</p>
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</td><td headers="hd_h_ch2.apph.tab51_1_1_1_5 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>0.69</p>
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<p>(−1.56, 2.95)</p>
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</td><td headers="hd_h_ch2.apph.tab51_1_1_1_6 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_7 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_8 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_9 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_10 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab51_1_1_1_11 hd_b_ch2.apph.tab51_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_h_ch2.apph.tab51_1_1_1_2 hd_h_ch2.apph.tab51_1_1_1_3 hd_h_ch2.apph.tab51_1_1_1_4 hd_h_ch2.apph.tab51_1_1_1_5 hd_h_ch2.apph.tab51_1_1_1_6 hd_h_ch2.apph.tab51_1_1_1_7 hd_h_ch2.apph.tab51_1_1_1_8 hd_h_ch2.apph.tab51_1_1_1_9 hd_h_ch2.apph.tab51_1_1_1_10 hd_h_ch2.apph.tab51_1_1_1_11" id="hd_b_ch2.apph.tab51_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab51_1_1_1_2 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab51_1_1_1_3 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">237</td><td headers="hd_h_ch2.apph.tab51_1_1_1_4 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.02</p>
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<p>(−0.28, 0.23)</p>
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</td><td headers="hd_h_ch2.apph.tab51_1_1_1_5 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−0.17</p>
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<p>(−2.43, 1.99)</p>
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</td><td headers="hd_h_ch2.apph.tab51_1_1_1_6 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_7 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_8 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_9 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_10 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab51_1_1_1_11 hd_b_ch2.apph.tab51_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_h_ch2.apph.tab51_1_1_1_2 hd_h_ch2.apph.tab51_1_1_1_3 hd_h_ch2.apph.tab51_1_1_1_4 hd_h_ch2.apph.tab51_1_1_1_5 hd_h_ch2.apph.tab51_1_1_1_6 hd_h_ch2.apph.tab51_1_1_1_7 hd_h_ch2.apph.tab51_1_1_1_8 hd_h_ch2.apph.tab51_1_1_1_9 hd_h_ch2.apph.tab51_1_1_1_10 hd_h_ch2.apph.tab51_1_1_1_11" id="hd_b_ch2.apph.tab51_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab51_1_1_1_2 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab51_1_1_1_3 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">97</td><td headers="hd_h_ch2.apph.tab51_1_1_1_4 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>RR 1.03</p>
|
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<p>(0.74, 1.44)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab51_1_1_1_5 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_6 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31 per 100</td><td headers="hd_h_ch2.apph.tab51_1_1_1_7 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>31 per 100</p>
|
|
<p>(23, 44)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab51_1_1_1_8 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_9 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_10 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab51_1_1_1_11 hd_b_ch2.apph.tab51_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_h_ch2.apph.tab51_1_1_1_2 hd_h_ch2.apph.tab51_1_1_1_3 hd_h_ch2.apph.tab51_1_1_1_4 hd_h_ch2.apph.tab51_1_1_1_5 hd_h_ch2.apph.tab51_1_1_1_6 hd_h_ch2.apph.tab51_1_1_1_7 hd_h_ch2.apph.tab51_1_1_1_8 hd_h_ch2.apph.tab51_1_1_1_9 hd_h_ch2.apph.tab51_1_1_1_10 hd_h_ch2.apph.tab51_1_1_1_11" id="hd_b_ch2.apph.tab51_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, HoNOSCA (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab51_1_1_1_2 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab51_1_1_1_3 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">169</td><td headers="hd_h_ch2.apph.tab51_1_1_1_4 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.80</p>
|
|
<p>(−2.87, 1.27)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab51_1_1_1_5 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_6 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_7 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_8 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_9 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_10 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab51_1_1_1_11 hd_b_ch2.apph.tab51_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_h_ch2.apph.tab51_1_1_1_2 hd_h_ch2.apph.tab51_1_1_1_3 hd_h_ch2.apph.tab51_1_1_1_4 hd_h_ch2.apph.tab51_1_1_1_5 hd_h_ch2.apph.tab51_1_1_1_6 hd_h_ch2.apph.tab51_1_1_1_7 hd_h_ch2.apph.tab51_1_1_1_8 hd_h_ch2.apph.tab51_1_1_1_9 hd_h_ch2.apph.tab51_1_1_1_10 hd_h_ch2.apph.tab51_1_1_1_11" id="hd_b_ch2.apph.tab51_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, HoNOSCA (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab51_1_1_1_2 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab51_1_1_1_3 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">169</td><td headers="hd_h_ch2.apph.tab51_1_1_1_4 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.30</p>
|
|
<p>(−2.23, 1.63)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab51_1_1_1_5 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_6 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_7 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_8 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_9 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_10 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab51_1_1_1_11 hd_b_ch2.apph.tab51_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_h_ch2.apph.tab51_1_1_1_2 hd_h_ch2.apph.tab51_1_1_1_3 hd_h_ch2.apph.tab51_1_1_1_4 hd_h_ch2.apph.tab51_1_1_1_5 hd_h_ch2.apph.tab51_1_1_1_6 hd_h_ch2.apph.tab51_1_1_1_7 hd_h_ch2.apph.tab51_1_1_1_8 hd_h_ch2.apph.tab51_1_1_1_9 hd_h_ch2.apph.tab51_1_1_1_10 hd_h_ch2.apph.tab51_1_1_1_11" id="hd_b_ch2.apph.tab51_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, HoNOSCA (values lower than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab51_1_1_1_2 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab51_1_1_1_3 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">177</td><td headers="hd_h_ch2.apph.tab51_1_1_1_4 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −1.10</p>
|
|
<p>(−2.95, 0.75)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab51_1_1_1_5 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_6 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_7 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_8 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_9 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_10 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab51_1_1_1_11 hd_b_ch2.apph.tab51_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_h_ch2.apph.tab51_1_1_1_2 hd_h_ch2.apph.tab51_1_1_1_3 hd_h_ch2.apph.tab51_1_1_1_4 hd_h_ch2.apph.tab51_1_1_1_5 hd_h_ch2.apph.tab51_1_1_1_6 hd_h_ch2.apph.tab51_1_1_1_7 hd_h_ch2.apph.tab51_1_1_1_8 hd_h_ch2.apph.tab51_1_1_1_9 hd_h_ch2.apph.tab51_1_1_1_10 hd_h_ch2.apph.tab51_1_1_1_11" id="hd_b_ch2.apph.tab51_1_1_15_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab51_1_1_1_1 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab51_1_1_1_2 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab51_1_1_1_3 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">178</td><td headers="hd_h_ch2.apph.tab51_1_1_1_4 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.68</p>
|
|
<p>(0.34, 1.36)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab51_1_1_1_5 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab51_1_1_1_6 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 per 100</td><td headers="hd_h_ch2.apph.tab51_1_1_1_7 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>9 per 100</p>
|
|
<p>(4, 17)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab51_1_1_1_8 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_9 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab51_1_1_1_10 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab51_1_1_1_11 hd_b_ch2.apph.tab51_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab51_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab51_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab52"><div id="ch2.apph.tab52" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab52/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab52_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab52_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab52_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab52_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab52_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab52_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: psychosocial intervention</th><th id="hd_h_ch2.apph.tab52_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: CBT (95% CI)</th><th id="hd_h_ch2.apph.tab52_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab52_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab52_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab52_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_h_ch2.apph.tab52_1_1_1_2 hd_h_ch2.apph.tab52_1_1_1_3 hd_h_ch2.apph.tab52_1_1_1_4 hd_h_ch2.apph.tab52_1_1_1_5 hd_h_ch2.apph.tab52_1_1_1_6 hd_h_ch2.apph.tab52_1_1_1_7 hd_h_ch2.apph.tab52_1_1_1_8 hd_h_ch2.apph.tab52_1_1_1_9 hd_h_ch2.apph.tab52_1_1_1_10 hd_h_ch2.apph.tab52_1_1_1_11" id="hd_b_ch2.apph.tab52_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab52_1_1_1_2 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab52_1_1_1_3 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">209</td><td headers="hd_h_ch2.apph.tab52_1_1_1_4 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.46</p>
|
|
<p>(−0.73, −0.18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_5 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.99</p>
|
|
<p>(−6.33, −1.56)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_6 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_7 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_8 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_9 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_10 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab52_1_1_1_11 hd_b_ch2.apph.tab52_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_h_ch2.apph.tab52_1_1_1_2 hd_h_ch2.apph.tab52_1_1_1_3 hd_h_ch2.apph.tab52_1_1_1_4 hd_h_ch2.apph.tab52_1_1_1_5 hd_h_ch2.apph.tab52_1_1_1_6 hd_h_ch2.apph.tab52_1_1_1_7 hd_h_ch2.apph.tab52_1_1_1_8 hd_h_ch2.apph.tab52_1_1_1_9 hd_h_ch2.apph.tab52_1_1_1_10 hd_h_ch2.apph.tab52_1_1_1_11" id="hd_b_ch2.apph.tab52_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab52_1_1_1_2 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab52_1_1_1_3 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">216</td><td headers="hd_h_ch2.apph.tab52_1_1_1_4 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.01</p>
|
|
<p>(−0.27, 0.26)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_5 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.09</p>
|
|
<p>(−2.34, 2.25)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_6 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_7 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_8 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_9 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_10 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab52_1_1_1_11 hd_b_ch2.apph.tab52_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_h_ch2.apph.tab52_1_1_1_2 hd_h_ch2.apph.tab52_1_1_1_3 hd_h_ch2.apph.tab52_1_1_1_4 hd_h_ch2.apph.tab52_1_1_1_5 hd_h_ch2.apph.tab52_1_1_1_6 hd_h_ch2.apph.tab52_1_1_1_7 hd_h_ch2.apph.tab52_1_1_1_8 hd_h_ch2.apph.tab52_1_1_1_9 hd_h_ch2.apph.tab52_1_1_1_10 hd_h_ch2.apph.tab52_1_1_1_11" id="hd_b_ch2.apph.tab52_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab52_1_1_1_2 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab52_1_1_1_3 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">239</td><td headers="hd_h_ch2.apph.tab52_1_1_1_4 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.09</p>
|
|
<p>(−0.35, 0.16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_5 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.78</p>
|
|
<p>(−3.03, 1.39)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_6 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_7 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_8 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_9 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_10 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab52_1_1_1_11 hd_b_ch2.apph.tab52_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_h_ch2.apph.tab52_1_1_1_2 hd_h_ch2.apph.tab52_1_1_1_3 hd_h_ch2.apph.tab52_1_1_1_4 hd_h_ch2.apph.tab52_1_1_1_5 hd_h_ch2.apph.tab52_1_1_1_6 hd_h_ch2.apph.tab52_1_1_1_7 hd_h_ch2.apph.tab52_1_1_1_8 hd_h_ch2.apph.tab52_1_1_1_9 hd_h_ch2.apph.tab52_1_1_1_10 hd_h_ch2.apph.tab52_1_1_1_11" id="hd_b_ch2.apph.tab52_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab52_1_1_1_2 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab52_1_1_1_3 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">313</td><td headers="hd_h_ch2.apph.tab52_1_1_1_4 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.04</p>
|
|
<p>(0.75, 1.45)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_5 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_6 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30 per 100</td><td headers="hd_h_ch2.apph.tab52_1_1_1_7 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>32 per 100</p>
|
|
<p>(23, 44)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_8 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_9 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_10 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab52_1_1_1_11 hd_b_ch2.apph.tab52_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_h_ch2.apph.tab52_1_1_1_2 hd_h_ch2.apph.tab52_1_1_1_3 hd_h_ch2.apph.tab52_1_1_1_4 hd_h_ch2.apph.tab52_1_1_1_5 hd_h_ch2.apph.tab52_1_1_1_6 hd_h_ch2.apph.tab52_1_1_1_7 hd_h_ch2.apph.tab52_1_1_1_8 hd_h_ch2.apph.tab52_1_1_1_9 hd_h_ch2.apph.tab52_1_1_1_10 hd_h_ch2.apph.tab52_1_1_1_11" id="hd_b_ch2.apph.tab52_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, HoNOSCA (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab52_1_1_1_2 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab52_1_1_1_3 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">169</td><td headers="hd_h_ch2.apph.tab52_1_1_1_4 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −1.80</p>
|
|
<p>(−3.97, 0.37)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_5 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_6 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_7 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_8 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_9 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_10 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab52_1_1_1_11 hd_b_ch2.apph.tab52_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_h_ch2.apph.tab52_1_1_1_2 hd_h_ch2.apph.tab52_1_1_1_3 hd_h_ch2.apph.tab52_1_1_1_4 hd_h_ch2.apph.tab52_1_1_1_5 hd_h_ch2.apph.tab52_1_1_1_6 hd_h_ch2.apph.tab52_1_1_1_7 hd_h_ch2.apph.tab52_1_1_1_8 hd_h_ch2.apph.tab52_1_1_1_9 hd_h_ch2.apph.tab52_1_1_1_10 hd_h_ch2.apph.tab52_1_1_1_11" id="hd_b_ch2.apph.tab52_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, HoNOSCA (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab52_1_1_1_2 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab52_1_1_1_3 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">169</td><td headers="hd_h_ch2.apph.tab52_1_1_1_4 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.50</p>
|
|
<p>(−2.47, 1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_5 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_6 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_7 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_8 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_9 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_10 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab52_1_1_1_11 hd_b_ch2.apph.tab52_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_h_ch2.apph.tab52_1_1_1_2 hd_h_ch2.apph.tab52_1_1_1_3 hd_h_ch2.apph.tab52_1_1_1_4 hd_h_ch2.apph.tab52_1_1_1_5 hd_h_ch2.apph.tab52_1_1_1_6 hd_h_ch2.apph.tab52_1_1_1_7 hd_h_ch2.apph.tab52_1_1_1_8 hd_h_ch2.apph.tab52_1_1_1_9 hd_h_ch2.apph.tab52_1_1_1_10 hd_h_ch2.apph.tab52_1_1_1_11" id="hd_b_ch2.apph.tab52_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, HoNOSCA (values lower than 0 favour individual CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab52_1_1_1_2 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab52_1_1_1_3 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">190</td><td headers="hd_h_ch2.apph.tab52_1_1_1_4 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.40</p>
|
|
<p>(−2.07, 1.27)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_5 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_6 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_7 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_8 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_9 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_10 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab52_1_1_1_11 hd_b_ch2.apph.tab52_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_h_ch2.apph.tab52_1_1_1_2 hd_h_ch2.apph.tab52_1_1_1_3 hd_h_ch2.apph.tab52_1_1_1_4 hd_h_ch2.apph.tab52_1_1_1_5 hd_h_ch2.apph.tab52_1_1_1_6 hd_h_ch2.apph.tab52_1_1_1_7 hd_h_ch2.apph.tab52_1_1_1_8 hd_h_ch2.apph.tab52_1_1_1_9 hd_h_ch2.apph.tab52_1_1_1_10 hd_h_ch2.apph.tab52_1_1_1_11" id="hd_b_ch2.apph.tab52_1_1_15_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour individual CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab52_1_1_1_1 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab52_1_1_1_2 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab52_1_1_1_3 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">289</td><td headers="hd_h_ch2.apph.tab52_1_1_1_4 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.52</p>
|
|
<p>(0.27, 0.99)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_5 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab52_1_1_1_6 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 per 100</td><td headers="hd_h_ch2.apph.tab52_1_1_1_7 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>8 per 100</p>
|
|
<p>(4, 16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab52_1_1_1_8 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_9 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab52_1_1_1_10 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab52_1_1_1_11 hd_b_ch2.apph.tab52_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab52_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab52_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab53"><div id="ch2.apph.tab53" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab53/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab53_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab53_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab53_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab53_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab53_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab53_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: relaxation</th><th id="hd_h_ch2.apph.tab53_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: CBT (95% CI)</th><th id="hd_h_ch2.apph.tab53_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab53_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab53_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab53_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_h_ch2.apph.tab53_1_1_1_2 hd_h_ch2.apph.tab53_1_1_1_3 hd_h_ch2.apph.tab53_1_1_1_4 hd_h_ch2.apph.tab53_1_1_1_5 hd_h_ch2.apph.tab53_1_1_1_6 hd_h_ch2.apph.tab53_1_1_1_7 hd_h_ch2.apph.tab53_1_1_1_8 hd_h_ch2.apph.tab53_1_1_1_9 hd_h_ch2.apph.tab53_1_1_1_10 hd_h_ch2.apph.tab53_1_1_1_11" id="hd_b_ch2.apph.tab53_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, GAS (values higher than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref80" rid="ch2.appo.ref80">Wood 1996</a>)</td><td headers="hd_h_ch2.apph.tab53_1_1_1_2 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab53_1_1_1_3 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53</td><td headers="hd_h_ch2.apph.tab53_1_1_1_4 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.38</p>
|
|
<p>(−0.16, 0.93)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_5 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>3.6</p>
|
|
<p>(−1.52, 8.81)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_6 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_7 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_8 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_9 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab53_1_1_1_10 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_11 hd_b_ch2.apph.tab53_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_h_ch2.apph.tab53_1_1_1_2 hd_h_ch2.apph.tab53_1_1_1_3 hd_h_ch2.apph.tab53_1_1_1_4 hd_h_ch2.apph.tab53_1_1_1_5 hd_h_ch2.apph.tab53_1_1_1_6 hd_h_ch2.apph.tab53_1_1_1_7 hd_h_ch2.apph.tab53_1_1_1_8 hd_h_ch2.apph.tab53_1_1_1_9 hd_h_ch2.apph.tab53_1_1_1_10 hd_h_ch2.apph.tab53_1_1_1_11" id="hd_b_ch2.apph.tab53_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, GAS (values higher than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref80" rid="ch2.appo.ref80">Wood 1996</a>)</td><td headers="hd_h_ch2.apph.tab53_1_1_1_2 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab53_1_1_1_3 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch2.apph.tab53_1_1_1_4 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.16</p>
|
|
<p>(−0.40, 0.73)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_5 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>1.52</p>
|
|
<p>(−3.79, 6.92)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_6 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_7 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_8 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_9 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab53_1_1_1_10 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_11 hd_b_ch2.apph.tab53_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_h_ch2.apph.tab53_1_1_1_2 hd_h_ch2.apph.tab53_1_1_1_3 hd_h_ch2.apph.tab53_1_1_1_4 hd_h_ch2.apph.tab53_1_1_1_5 hd_h_ch2.apph.tab53_1_1_1_6 hd_h_ch2.apph.tab53_1_1_1_7 hd_h_ch2.apph.tab53_1_1_1_8 hd_h_ch2.apph.tab53_1_1_1_9 hd_h_ch2.apph.tab53_1_1_1_10 hd_h_ch2.apph.tab53_1_1_1_11" id="hd_b_ch2.apph.tab53_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref80" rid="ch2.appo.ref80">Wood 1996</a>)</td><td headers="hd_h_ch2.apph.tab53_1_1_1_2 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab53_1_1_1_3 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch2.apph.tab53_1_1_1_4 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.71</p>
|
|
<p>(−1.27, −0.15)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_5 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−6.15</p>
|
|
<p>(−11.01, −1.3)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_6 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_7 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_8 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_9 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab53_1_1_1_10 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_11 hd_b_ch2.apph.tab53_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_h_ch2.apph.tab53_1_1_1_2 hd_h_ch2.apph.tab53_1_1_1_3 hd_h_ch2.apph.tab53_1_1_1_4 hd_h_ch2.apph.tab53_1_1_1_5 hd_h_ch2.apph.tab53_1_1_1_6 hd_h_ch2.apph.tab53_1_1_1_7 hd_h_ch2.apph.tab53_1_1_1_8 hd_h_ch2.apph.tab53_1_1_1_9 hd_h_ch2.apph.tab53_1_1_1_10 hd_h_ch2.apph.tab53_1_1_1_11" id="hd_b_ch2.apph.tab53_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref80" rid="ch2.appo.ref80">Wood 1996</a>)</td><td headers="hd_h_ch2.apph.tab53_1_1_1_2 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab53_1_1_1_3 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch2.apph.tab53_1_1_1_4 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.12</p>
|
|
<p>(−0.69, 0.45)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_5 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.04</p>
|
|
<p>(−5.98, 3.9)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_6 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_7 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_8 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_9 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab53_1_1_1_10 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_11 hd_b_ch2.apph.tab53_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_h_ch2.apph.tab53_1_1_1_2 hd_h_ch2.apph.tab53_1_1_1_3 hd_h_ch2.apph.tab53_1_1_1_4 hd_h_ch2.apph.tab53_1_1_1_5 hd_h_ch2.apph.tab53_1_1_1_6 hd_h_ch2.apph.tab53_1_1_1_7 hd_h_ch2.apph.tab53_1_1_1_8 hd_h_ch2.apph.tab53_1_1_1_9 hd_h_ch2.apph.tab53_1_1_1_10 hd_h_ch2.apph.tab53_1_1_1_11" id="hd_b_ch2.apph.tab53_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref80" rid="ch2.appo.ref80">Wood 1996</a>)</td><td headers="hd_h_ch2.apph.tab53_1_1_1_2 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab53_1_1_1_3 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch2.apph.tab53_1_1_1_4 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.60</p>
|
|
<p>(1.10, 6.16)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_5 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_6 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21 per 100</td><td headers="hd_h_ch2.apph.tab53_1_1_1_7 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>54 per 100</p>
|
|
<p>(23, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_8 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_9 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab53_1_1_1_10 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_11 hd_b_ch2.apph.tab53_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_h_ch2.apph.tab53_1_1_1_2 hd_h_ch2.apph.tab53_1_1_1_3 hd_h_ch2.apph.tab53_1_1_1_4 hd_h_ch2.apph.tab53_1_1_1_5 hd_h_ch2.apph.tab53_1_1_1_6 hd_h_ch2.apph.tab53_1_1_1_7 hd_h_ch2.apph.tab53_1_1_1_8 hd_h_ch2.apph.tab53_1_1_1_9 hd_h_ch2.apph.tab53_1_1_1_10 hd_h_ch2.apph.tab53_1_1_1_11" id="hd_b_ch2.apph.tab53_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour individual CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref80" rid="ch2.appo.ref80">Wood 1996</a>)</td><td headers="hd_h_ch2.apph.tab53_1_1_1_2 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab53_1_1_1_3 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43</td><td headers="hd_h_ch2.apph.tab53_1_1_1_4 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.43</p>
|
|
<p>(0.74, 2.79)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_5 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_6 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38 per 100</td><td headers="hd_h_ch2.apph.tab53_1_1_1_7 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>54 per 100</p>
|
|
<p>(28, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_8 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_9 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab53_1_1_1_10 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_11 hd_b_ch2.apph.tab53_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_h_ch2.apph.tab53_1_1_1_2 hd_h_ch2.apph.tab53_1_1_1_3 hd_h_ch2.apph.tab53_1_1_1_4 hd_h_ch2.apph.tab53_1_1_1_5 hd_h_ch2.apph.tab53_1_1_1_6 hd_h_ch2.apph.tab53_1_1_1_7 hd_h_ch2.apph.tab53_1_1_1_8 hd_h_ch2.apph.tab53_1_1_1_9 hd_h_ch2.apph.tab53_1_1_1_10 hd_h_ch2.apph.tab53_1_1_1_11" id="hd_b_ch2.apph.tab53_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation (values lower than 1 favour individual CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab53_1_1_1_1 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref80" rid="ch2.appo.ref80">Wood 1996</a>)</td><td headers="hd_h_ch2.apph.tab53_1_1_1_2 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab53_1_1_1_3 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53</td><td headers="hd_h_ch2.apph.tab53_1_1_1_4 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.69</p>
|
|
<p>(0.13, 3.81)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_5 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab53_1_1_1_6 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11 per 100</td><td headers="hd_h_ch2.apph.tab53_1_1_1_7 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>8 per 100</p>
|
|
<p>(1, 42)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab53_1_1_1_8 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_9 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab53_1_1_1_10 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab53_1_1_1_11 hd_b_ch2.apph.tab53_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab53_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab53_2"><p class="no_margin">SMD to MD conversion on CGAS scale using pooled SD for all studies using this scale (9.47517)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab53_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab53_4"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab54"><div id="ch2.apph.tab54" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab54/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab54_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab54_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab54_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab54_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab54_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab54_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab54_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab54_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab54_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab54_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab54_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab54_1_1_1_1 hd_h_ch2.apph.tab54_1_1_1_2 hd_h_ch2.apph.tab54_1_1_1_3 hd_h_ch2.apph.tab54_1_1_1_4 hd_h_ch2.apph.tab54_1_1_1_5 hd_h_ch2.apph.tab54_1_1_1_6 hd_h_ch2.apph.tab54_1_1_1_7 hd_h_ch2.apph.tab54_1_1_1_8 hd_h_ch2.apph.tab54_1_1_1_9 hd_h_ch2.apph.tab54_1_1_1_10 hd_h_ch2.apph.tab54_1_1_1_11" id="hd_b_ch2.apph.tab54_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI-II (values lower than 0 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab54_1_1_1_1 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref71" rid="ch2.appo.ref71">Topooco 2018</a>)</td><td headers="hd_h_ch2.apph.tab54_1_1_1_2 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab54_1_1_1_3 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70</td><td headers="hd_h_ch2.apph.tab54_1_1_1_4 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.68</p>
|
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<p>(−1.16, −0.19)</p>
|
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</td><td headers="hd_h_ch2.apph.tab54_1_1_1_5 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
|
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<p>−5.89</p>
|
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<p>(−10.05, −1.65)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab54_1_1_1_6 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab54_1_1_1_7 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab54_1_1_1_8 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab54_1_1_1_9 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab54_1_1_1_10 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab54_1_1_1_11 hd_b_ch2.apph.tab54_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab54_1_1_1_1 hd_h_ch2.apph.tab54_1_1_1_2 hd_h_ch2.apph.tab54_1_1_1_3 hd_h_ch2.apph.tab54_1_1_1_4 hd_h_ch2.apph.tab54_1_1_1_5 hd_h_ch2.apph.tab54_1_1_1_6 hd_h_ch2.apph.tab54_1_1_1_7 hd_h_ch2.apph.tab54_1_1_1_8 hd_h_ch2.apph.tab54_1_1_1_9 hd_h_ch2.apph.tab54_1_1_1_10 hd_h_ch2.apph.tab54_1_1_1_11" id="hd_b_ch2.apph.tab54_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour computer CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab54_1_1_1_1 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref71" rid="ch2.appo.ref71">Topooco 2018</a>)</td><td headers="hd_h_ch2.apph.tab54_1_1_1_2 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab54_1_1_1_3 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70</td><td headers="hd_h_ch2.apph.tab54_1_1_1_4 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>RR 5.61</p>
|
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<p>(2.13, 14.72)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab54_1_1_1_5 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab54_1_1_1_6 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11 per 100</td><td headers="hd_h_ch2.apph.tab54_1_1_1_7 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>61 per 100</p>
|
|
<p>(23, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab54_1_1_1_8 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab54_1_1_1_9 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab54_1_1_1_10 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab54_1_1_1_11 hd_b_ch2.apph.tab54_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab54_1_1_1_1 hd_h_ch2.apph.tab54_1_1_1_2 hd_h_ch2.apph.tab54_1_1_1_3 hd_h_ch2.apph.tab54_1_1_1_4 hd_h_ch2.apph.tab54_1_1_1_5 hd_h_ch2.apph.tab54_1_1_1_6 hd_h_ch2.apph.tab54_1_1_1_7 hd_h_ch2.apph.tab54_1_1_1_8 hd_h_ch2.apph.tab54_1_1_1_9 hd_h_ch2.apph.tab54_1_1_1_10 hd_h_ch2.apph.tab54_1_1_1_11" id="hd_b_ch2.apph.tab54_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour computer CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab54_1_1_1_1 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref71" rid="ch2.appo.ref71">Topooco 2018</a>)</td><td headers="hd_h_ch2.apph.tab54_1_1_1_2 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab54_1_1_1_3 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70</td><td headers="hd_h_ch2.apph.tab54_1_1_1_4 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 2.80</p>
|
|
<p>(0.58, 13.49)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab54_1_1_1_5 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab54_1_1_1_6 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 per 100</td><td headers="hd_h_ch2.apph.tab54_1_1_1_7 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>15 per 100</p>
|
|
<p>(3, 73)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab54_1_1_1_8 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab54_1_1_1_9 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab54_1_1_1_10 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab54_1_1_1_11 hd_b_ch2.apph.tab54_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab54_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab54_2"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab54_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab55"><div id="ch2.apph.tab55" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab55/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab55_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab55_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab55_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab55_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab55_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab55_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab55_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab55_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab55_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab55_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab55_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab55_1_1_1_1 hd_h_ch2.apph.tab55_1_1_1_2 hd_h_ch2.apph.tab55_1_1_1_3 hd_h_ch2.apph.tab55_1_1_1_4 hd_h_ch2.apph.tab55_1_1_1_5 hd_h_ch2.apph.tab55_1_1_1_6 hd_h_ch2.apph.tab55_1_1_1_7 hd_h_ch2.apph.tab55_1_1_1_8 hd_h_ch2.apph.tab55_1_1_1_9 hd_h_ch2.apph.tab55_1_1_1_10 hd_h_ch2.apph.tab55_1_1_1_11" id="hd_b_ch2.apph.tab55_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, GAF (values higher than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab55_1_1_1_1 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>)</td><td headers="hd_h_ch2.apph.tab55_1_1_1_2 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab55_1_1_1_3 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_ch2.apph.tab55_1_1_1_4 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.42</p>
|
|
<p>(−0.08, 0.93)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab55_1_1_1_5 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>3.98</p>
|
|
<p>(−0.76, 8.81)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab55_1_1_1_6 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab55_1_1_1_7 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab55_1_1_1_8 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab55_1_1_1_9 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab55_1_1_1_10 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab55_1_1_1_11 hd_b_ch2.apph.tab55_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab55_1_1_1_1 hd_h_ch2.apph.tab55_1_1_1_2 hd_h_ch2.apph.tab55_1_1_1_3 hd_h_ch2.apph.tab55_1_1_1_4 hd_h_ch2.apph.tab55_1_1_1_5 hd_h_ch2.apph.tab55_1_1_1_6 hd_h_ch2.apph.tab55_1_1_1_7 hd_h_ch2.apph.tab55_1_1_1_8 hd_h_ch2.apph.tab55_1_1_1_9 hd_h_ch2.apph.tab55_1_1_1_10 hd_h_ch2.apph.tab55_1_1_1_11" id="hd_b_ch2.apph.tab55_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab55_1_1_1_1 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>, <a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab55_1_1_1_2 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab55_1_1_1_3 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">102</td><td headers="hd_h_ch2.apph.tab55_1_1_1_4 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.77</p>
|
|
<p>(−1.18, −0.37)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab55_1_1_1_5 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−6.67</p>
|
|
<p>(−10.23, −3.21)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab55_1_1_1_6 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab55_1_1_1_7 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab55_1_1_1_8 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab55_1_1_1_9 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab55_1_1_1_10 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab55_1_1_1_11 hd_b_ch2.apph.tab55_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab55_1_1_1_1 hd_h_ch2.apph.tab55_1_1_1_2 hd_h_ch2.apph.tab55_1_1_1_3 hd_h_ch2.apph.tab55_1_1_1_4 hd_h_ch2.apph.tab55_1_1_1_5 hd_h_ch2.apph.tab55_1_1_1_6 hd_h_ch2.apph.tab55_1_1_1_7 hd_h_ch2.apph.tab55_1_1_1_8 hd_h_ch2.apph.tab55_1_1_1_9 hd_h_ch2.apph.tab55_1_1_1_10 hd_h_ch2.apph.tab55_1_1_1_11" id="hd_b_ch2.apph.tab55_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab55_1_1_1_1 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab55_1_1_1_2 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab55_1_1_1_3 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch2.apph.tab55_1_1_1_4 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 7.88</p>
|
|
<p>(1.13, 54.66)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab55_1_1_1_5 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab55_1_1_1_6 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7 per 100</td><td headers="hd_h_ch2.apph.tab55_1_1_1_7 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>56 per 100</p>
|
|
<p>(8, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab55_1_1_1_8 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab55_1_1_1_9 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab55_1_1_1_10 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab55_1_1_1_11 hd_b_ch2.apph.tab55_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab55_1_1_1_1 hd_h_ch2.apph.tab55_1_1_1_2 hd_h_ch2.apph.tab55_1_1_1_3 hd_h_ch2.apph.tab55_1_1_1_4 hd_h_ch2.apph.tab55_1_1_1_5 hd_h_ch2.apph.tab55_1_1_1_6 hd_h_ch2.apph.tab55_1_1_1_7 hd_h_ch2.apph.tab55_1_1_1_8 hd_h_ch2.apph.tab55_1_1_1_9 hd_h_ch2.apph.tab55_1_1_1_10 hd_h_ch2.apph.tab55_1_1_1_11" id="hd_b_ch2.apph.tab55_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab55_1_1_1_1 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>, <a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab55_1_1_1_2 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab55_1_1_1_3 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">121</td><td headers="hd_h_ch2.apph.tab55_1_1_1_4 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.65</p>
|
|
<p>(0.32, 1.32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab55_1_1_1_5 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab55_1_1_1_6 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25 per 100</td><td headers="hd_h_ch2.apph.tab55_1_1_1_7 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>17 per 100</p>
|
|
<p>(8, 34)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab55_1_1_1_8 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab55_1_1_1_9 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab55_1_1_1_10 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab55_1_1_1_11 hd_b_ch2.apph.tab55_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab55_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab55_2"><p class="no_margin">SMD to MD conversion on CGAS scale using pooled SD for all studies using this scale (9.47517)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab55_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab55_4"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab56"><div id="ch2.apph.tab56" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab56/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab56_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab56_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab56_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab56_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab56_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab56_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab56_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab56_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab56_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab56_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab56_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_h_ch2.apph.tab56_1_1_1_2 hd_h_ch2.apph.tab56_1_1_1_3 hd_h_ch2.apph.tab56_1_1_1_4 hd_h_ch2.apph.tab56_1_1_1_5 hd_h_ch2.apph.tab56_1_1_1_6 hd_h_ch2.apph.tab56_1_1_1_7 hd_h_ch2.apph.tab56_1_1_1_8 hd_h_ch2.apph.tab56_1_1_1_9 hd_h_ch2.apph.tab56_1_1_1_10 hd_h_ch2.apph.tab56_1_1_1_11" id="hd_b_ch2.apph.tab56_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, GAF (values higher than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref13" rid="ch2.appo.ref13">Clarke 2002</a>)</td><td headers="hd_h_ch2.apph.tab56_1_1_1_2 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab56_1_1_1_3 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86</td><td headers="hd_h_ch2.apph.tab56_1_1_1_4 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.15</p>
|
|
<p>(−0.27, 0.58)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_5 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>**</sup>CGAS scale</p>
|
|
<p>1.42</p>
|
|
<p>(−2.56, 5.5)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_6 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_7 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_8 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_9 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab56_1_1_1_10 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_11 hd_b_ch2.apph.tab56_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_h_ch2.apph.tab56_1_1_1_2 hd_h_ch2.apph.tab56_1_1_1_3 hd_h_ch2.apph.tab56_1_1_1_4 hd_h_ch2.apph.tab56_1_1_1_5 hd_h_ch2.apph.tab56_1_1_1_6 hd_h_ch2.apph.tab56_1_1_1_7 hd_h_ch2.apph.tab56_1_1_1_8 hd_h_ch2.apph.tab56_1_1_1_9 hd_h_ch2.apph.tab56_1_1_1_10 hd_h_ch2.apph.tab56_1_1_1_11" id="hd_b_ch2.apph.tab56_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, GAF (values higher than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref13" rid="ch2.appo.ref13">Clarke 2002</a>)</td><td headers="hd_h_ch2.apph.tab56_1_1_1_2 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab56_1_1_1_3 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73</td><td headers="hd_h_ch2.apph.tab56_1_1_1_4 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.05</p>
|
|
<p>(−0.51, 0.41)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_5 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>−0.47</p>
|
|
<p>(−4.83, 3.88)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_6 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_7 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_8 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_9 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab56_1_1_1_10 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_11 hd_b_ch2.apph.tab56_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_h_ch2.apph.tab56_1_1_1_2 hd_h_ch2.apph.tab56_1_1_1_3 hd_h_ch2.apph.tab56_1_1_1_4 hd_h_ch2.apph.tab56_1_1_1_5 hd_h_ch2.apph.tab56_1_1_1_6 hd_h_ch2.apph.tab56_1_1_1_7 hd_h_ch2.apph.tab56_1_1_1_8 hd_h_ch2.apph.tab56_1_1_1_9 hd_h_ch2.apph.tab56_1_1_1_10 hd_h_ch2.apph.tab56_1_1_1_11" id="hd_b_ch2.apph.tab56_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, HAM-D (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref13" rid="ch2.appo.ref13">Clarke 2002</a>)</td><td headers="hd_h_ch2.apph.tab56_1_1_1_2 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab56_1_1_1_3 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86</td><td headers="hd_h_ch2.apph.tab56_1_1_1_4 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.21</p>
|
|
<p>(−0.64, 0.21)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_5 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−1.82</p>
|
|
<p>(−5.55, 1.82)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_6 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_7 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_8 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_9 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab56_1_1_1_10 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_11 hd_b_ch2.apph.tab56_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_h_ch2.apph.tab56_1_1_1_2 hd_h_ch2.apph.tab56_1_1_1_3 hd_h_ch2.apph.tab56_1_1_1_4 hd_h_ch2.apph.tab56_1_1_1_5 hd_h_ch2.apph.tab56_1_1_1_6 hd_h_ch2.apph.tab56_1_1_1_7 hd_h_ch2.apph.tab56_1_1_1_8 hd_h_ch2.apph.tab56_1_1_1_9 hd_h_ch2.apph.tab56_1_1_1_10 hd_h_ch2.apph.tab56_1_1_1_11" id="hd_b_ch2.apph.tab56_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, HAM-D (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref13" rid="ch2.appo.ref13">Clarke 2002</a>)</td><td headers="hd_h_ch2.apph.tab56_1_1_1_2 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab56_1_1_1_3 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73</td><td headers="hd_h_ch2.apph.tab56_1_1_1_4 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD 0.08</p>
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<p>(−0.38, 0.54)</p>
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|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_5 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>0.69</p>
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|
<p>(−3.29, 4.68)</p>
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|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_6 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_7 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_8 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_9 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab56_1_1_1_10 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_11 hd_b_ch2.apph.tab56_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_h_ch2.apph.tab56_1_1_1_2 hd_h_ch2.apph.tab56_1_1_1_3 hd_h_ch2.apph.tab56_1_1_1_4 hd_h_ch2.apph.tab56_1_1_1_5 hd_h_ch2.apph.tab56_1_1_1_6 hd_h_ch2.apph.tab56_1_1_1_7 hd_h_ch2.apph.tab56_1_1_1_8 hd_h_ch2.apph.tab56_1_1_1_9 hd_h_ch2.apph.tab56_1_1_1_10 hd_h_ch2.apph.tab56_1_1_1_11" id="hd_b_ch2.apph.tab56_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, K-SADS (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref13" rid="ch2.appo.ref13">Clarke 2002</a>)</td><td headers="hd_h_ch2.apph.tab56_1_1_1_2 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab56_1_1_1_3 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">86</td><td headers="hd_h_ch2.apph.tab56_1_1_1_4 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 0.10</p>
|
|
<p>(−0.42, 0.62)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_5 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_6 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_7 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_8 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_9 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab56_1_1_1_10 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_11 hd_b_ch2.apph.tab56_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_h_ch2.apph.tab56_1_1_1_2 hd_h_ch2.apph.tab56_1_1_1_3 hd_h_ch2.apph.tab56_1_1_1_4 hd_h_ch2.apph.tab56_1_1_1_5 hd_h_ch2.apph.tab56_1_1_1_6 hd_h_ch2.apph.tab56_1_1_1_7 hd_h_ch2.apph.tab56_1_1_1_8 hd_h_ch2.apph.tab56_1_1_1_9 hd_h_ch2.apph.tab56_1_1_1_10 hd_h_ch2.apph.tab56_1_1_1_11" id="hd_b_ch2.apph.tab56_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation, K-SADS (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab56_1_1_1_1 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref13" rid="ch2.appo.ref13">Clarke 2002</a>)</td><td headers="hd_h_ch2.apph.tab56_1_1_1_2 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab56_1_1_1_3 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73</td><td headers="hd_h_ch2.apph.tab56_1_1_1_4 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −0.20</p>
|
|
<p>(−0.72, 0.32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab56_1_1_1_5 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_6 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_7 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab56_1_1_1_8 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_9 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab56_1_1_1_10 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab56_1_1_1_11 hd_b_ch2.apph.tab56_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab56_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab56_2"><p class="no_margin">SMD to MD conversion on CGAS scale using pooled SD for all studies using this scale (9.47517)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab56_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab56_4"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab57"><div id="ch2.apph.tab57" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab57/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab57_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab57_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab57_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab57_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab57_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab57_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group CBT + parent</th><th id="hd_h_ch2.apph.tab57_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group CBT (95% CI)</th><th id="hd_h_ch2.apph.tab57_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab57_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab57_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab57_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_h_ch2.apph.tab57_1_1_1_2 hd_h_ch2.apph.tab57_1_1_1_3 hd_h_ch2.apph.tab57_1_1_1_4 hd_h_ch2.apph.tab57_1_1_1_5 hd_h_ch2.apph.tab57_1_1_1_6 hd_h_ch2.apph.tab57_1_1_1_7 hd_h_ch2.apph.tab57_1_1_1_8 hd_h_ch2.apph.tab57_1_1_1_9 hd_h_ch2.apph.tab57_1_1_1_10 hd_h_ch2.apph.tab57_1_1_1_11" id="hd_b_ch2.apph.tab57_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, GAF (values higher than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>)</td><td headers="hd_h_ch2.apph.tab57_1_1_1_2 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab57_1_1_1_3 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69</td><td headers="hd_h_ch2.apph.tab57_1_1_1_4 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.42</p>
|
|
<p>(−0.90, 0.06)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_5 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>−3.98</p>
|
|
<p>(−8.53, 0.57)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_6 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_7 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_8 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_9 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab57_1_1_1_10 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_11 hd_b_ch2.apph.tab57_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_h_ch2.apph.tab57_1_1_1_2 hd_h_ch2.apph.tab57_1_1_1_3 hd_h_ch2.apph.tab57_1_1_1_4 hd_h_ch2.apph.tab57_1_1_1_5 hd_h_ch2.apph.tab57_1_1_1_6 hd_h_ch2.apph.tab57_1_1_1_7 hd_h_ch2.apph.tab57_1_1_1_8 hd_h_ch2.apph.tab57_1_1_1_9 hd_h_ch2.apph.tab57_1_1_1_10 hd_h_ch2.apph.tab57_1_1_1_11" id="hd_b_ch2.apph.tab57_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>, <a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab57_1_1_1_2 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab57_1_1_1_3 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">109</td><td headers="hd_h_ch2.apph.tab57_1_1_1_4 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.06</p>
|
|
<p>(−0.67, 0.54)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_5 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.52</p>
|
|
<p>(−5.81, 4.68)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_6 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_7 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_8 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_9 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab57_1_1_1_10 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_11 hd_b_ch2.apph.tab57_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_h_ch2.apph.tab57_1_1_1_2 hd_h_ch2.apph.tab57_1_1_1_3 hd_h_ch2.apph.tab57_1_1_1_4 hd_h_ch2.apph.tab57_1_1_1_5 hd_h_ch2.apph.tab57_1_1_1_6 hd_h_ch2.apph.tab57_1_1_1_7 hd_h_ch2.apph.tab57_1_1_1_8 hd_h_ch2.apph.tab57_1_1_1_9 hd_h_ch2.apph.tab57_1_1_1_10 hd_h_ch2.apph.tab57_1_1_1_11" id="hd_b_ch2.apph.tab57_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab57_1_1_1_2 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab57_1_1_1_3 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_ch2.apph.tab57_1_1_1_4 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.11</p>
|
|
<p>(−0.60, 0.83)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_5 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>0.95</p>
|
|
<p>(−5.2, 7.19)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_6 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_7 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_8 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_9 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab57_1_1_1_10 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_11 hd_b_ch2.apph.tab57_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_h_ch2.apph.tab57_1_1_1_2 hd_h_ch2.apph.tab57_1_1_1_3 hd_h_ch2.apph.tab57_1_1_1_4 hd_h_ch2.apph.tab57_1_1_1_5 hd_h_ch2.apph.tab57_1_1_1_6 hd_h_ch2.apph.tab57_1_1_1_7 hd_h_ch2.apph.tab57_1_1_1_8 hd_h_ch2.apph.tab57_1_1_1_9 hd_h_ch2.apph.tab57_1_1_1_10 hd_h_ch2.apph.tab57_1_1_1_11" id="hd_b_ch2.apph.tab57_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour group CBT) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab57_1_1_1_2 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab57_1_1_1_3 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29</td><td headers="hd_h_ch2.apph.tab57_1_1_1_4 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.12</p>
|
|
<p>(−0.61, 0.85)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_5 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>1.04</p>
|
|
<p>(−5.29, 7.37)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_6 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_7 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_8 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_9 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab57_1_1_1_10 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_11 hd_b_ch2.apph.tab57_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_h_ch2.apph.tab57_1_1_1_2 hd_h_ch2.apph.tab57_1_1_1_3 hd_h_ch2.apph.tab57_1_1_1_4 hd_h_ch2.apph.tab57_1_1_1_5 hd_h_ch2.apph.tab57_1_1_1_6 hd_h_ch2.apph.tab57_1_1_1_7 hd_h_ch2.apph.tab57_1_1_1_8 hd_h_ch2.apph.tab57_1_1_1_9 hd_h_ch2.apph.tab57_1_1_1_10 hd_h_ch2.apph.tab57_1_1_1_11" id="hd_b_ch2.apph.tab57_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour group CBT) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab57_1_1_1_2 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab57_1_1_1_3 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35</td><td headers="hd_h_ch2.apph.tab57_1_1_1_4 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.34</p>
|
|
<p>(0.68, 2.64)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_5 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_6 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42 per 100</td><td headers="hd_h_ch2.apph.tab57_1_1_1_7 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>56 per 100</p>
|
|
<p>(29, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_8 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_9 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab57_1_1_1_10 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_11 hd_b_ch2.apph.tab57_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_h_ch2.apph.tab57_1_1_1_2 hd_h_ch2.apph.tab57_1_1_1_3 hd_h_ch2.apph.tab57_1_1_1_4 hd_h_ch2.apph.tab57_1_1_1_5 hd_h_ch2.apph.tab57_1_1_1_6 hd_h_ch2.apph.tab57_1_1_1_7 hd_h_ch2.apph.tab57_1_1_1_8 hd_h_ch2.apph.tab57_1_1_1_9 hd_h_ch2.apph.tab57_1_1_1_10 hd_h_ch2.apph.tab57_1_1_1_11" id="hd_b_ch2.apph.tab57_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT)</th></tr><tr><td headers="hd_h_ch2.apph.tab57_1_1_1_1 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>, <a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab57_1_1_1_2 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab57_1_1_1_3 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">127</td><td headers="hd_h_ch2.apph.tab57_1_1_1_4 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.85</p>
|
|
<p>(0.41, 1.78)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_5 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab57_1_1_1_6 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20 per 100</td><td headers="hd_h_ch2.apph.tab57_1_1_1_7 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>17 per 100</p>
|
|
<p>(8, 35)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab57_1_1_1_8 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab57_1_1_1_9 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab57_1_1_1_10 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab57_1_1_1_11 hd_b_ch2.apph.tab57_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab57_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab57_2"><p class="no_margin">SMD to MD conversion on CGAS scale using pooled SD for all studies using this scale (9.47517)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab57_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab57_4"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab57_5"><p class="no_margin">I<sup>2</sup>>33.3%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab58"><div id="ch2.apph.tab58" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab58/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab58_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab58_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab58_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab58_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab58_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab58_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab58_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab58_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab58_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab58_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab58_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab58_1_1_1_1 hd_h_ch2.apph.tab58_1_1_1_2 hd_h_ch2.apph.tab58_1_1_1_3 hd_h_ch2.apph.tab58_1_1_1_4 hd_h_ch2.apph.tab58_1_1_1_5 hd_h_ch2.apph.tab58_1_1_1_6 hd_h_ch2.apph.tab58_1_1_1_7 hd_h_ch2.apph.tab58_1_1_1_8 hd_h_ch2.apph.tab58_1_1_1_9 hd_h_ch2.apph.tab58_1_1_1_10 hd_h_ch2.apph.tab58_1_1_1_11" id="hd_b_ch2.apph.tab58_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, GAF (values higher than 0 favour group CBT and parent sessions) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab58_1_1_1_1 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>)</td><td headers="hd_h_ch2.apph.tab58_1_1_1_2 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab58_1_1_1_3 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59</td><td headers="hd_h_ch2.apph.tab58_1_1_1_4 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.78</p>
|
|
<p>(0.25, 1.31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab58_1_1_1_5 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>**</sup>CGAS scale</p>
|
|
<p>7.39</p>
|
|
<p>(2.37, 12.41)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab58_1_1_1_6 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab58_1_1_1_7 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab58_1_1_1_8 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab58_1_1_1_9 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab58_1_1_1_10 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab58_1_1_1_11 hd_b_ch2.apph.tab58_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab58_1_1_1_1 hd_h_ch2.apph.tab58_1_1_1_2 hd_h_ch2.apph.tab58_1_1_1_3 hd_h_ch2.apph.tab58_1_1_1_4 hd_h_ch2.apph.tab58_1_1_1_5 hd_h_ch2.apph.tab58_1_1_1_6 hd_h_ch2.apph.tab58_1_1_1_7 hd_h_ch2.apph.tab58_1_1_1_8 hd_h_ch2.apph.tab58_1_1_1_9 hd_h_ch2.apph.tab58_1_1_1_10 hd_h_ch2.apph.tab58_1_1_1_11" id="hd_b_ch2.apph.tab58_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour group CBT and parent sessions) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab58_1_1_1_1 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>, <a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab58_1_1_1_2 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab58_1_1_1_3 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">99</td><td headers="hd_h_ch2.apph.tab58_1_1_1_4 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.72</p>
|
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<p>(−1.30, −0.14)</p>
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|
</td><td headers="hd_h_ch2.apph.tab58_1_1_1_5 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
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<p>−6.24</p>
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<p>(−11.27, −1.21)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab58_1_1_1_6 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab58_1_1_1_7 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab58_1_1_1_8 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab58_1_1_1_9 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab58_1_1_1_10 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab58_1_1_1_11 hd_b_ch2.apph.tab58_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab58_1_1_1_1 hd_h_ch2.apph.tab58_1_1_1_2 hd_h_ch2.apph.tab58_1_1_1_3 hd_h_ch2.apph.tab58_1_1_1_4 hd_h_ch2.apph.tab58_1_1_1_5 hd_h_ch2.apph.tab58_1_1_1_6 hd_h_ch2.apph.tab58_1_1_1_7 hd_h_ch2.apph.tab58_1_1_1_8 hd_h_ch2.apph.tab58_1_1_1_9 hd_h_ch2.apph.tab58_1_1_1_10 hd_h_ch2.apph.tab58_1_1_1_11" id="hd_b_ch2.apph.tab58_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour group CBT and parent sessions) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab58_1_1_1_1 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab58_1_1_1_2 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab58_1_1_1_3 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_ch2.apph.tab58_1_1_1_4 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 5.89</p>
|
|
<p>(0.83, 41.89)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab58_1_1_1_5 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab58_1_1_1_6 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7 per 100</td><td headers="hd_h_ch2.apph.tab58_1_1_1_7 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>42 per 100</p>
|
|
<p>(6, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab58_1_1_1_8 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab58_1_1_1_9 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab58_1_1_1_10 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab58_1_1_1_11 hd_b_ch2.apph.tab58_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab58_1_1_1_1 hd_h_ch2.apph.tab58_1_1_1_2 hd_h_ch2.apph.tab58_1_1_1_3 hd_h_ch2.apph.tab58_1_1_1_4 hd_h_ch2.apph.tab58_1_1_1_5 hd_h_ch2.apph.tab58_1_1_1_6 hd_h_ch2.apph.tab58_1_1_1_7 hd_h_ch2.apph.tab58_1_1_1_8 hd_h_ch2.apph.tab58_1_1_1_9 hd_h_ch2.apph.tab58_1_1_1_10 hd_h_ch2.apph.tab58_1_1_1_11" id="hd_b_ch2.apph.tab58_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour group CBT and parent sessions)</th></tr><tr><td headers="hd_h_ch2.apph.tab58_1_1_1_1 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>, <a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewisohn 1990</a>)</td><td headers="hd_h_ch2.apph.tab58_1_1_1_2 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab58_1_1_1_3 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">116</td><td headers="hd_h_ch2.apph.tab58_1_1_1_4 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.76</p>
|
|
<p>(0.38, 1.52)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab58_1_1_1_5 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab58_1_1_1_6 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25 per 100</td><td headers="hd_h_ch2.apph.tab58_1_1_1_7 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>19 per 100</p>
|
|
<p>(10, 39)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab58_1_1_1_8 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab58_1_1_1_9 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab58_1_1_1_10 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab58_1_1_1_11 hd_b_ch2.apph.tab58_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab58_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>**</dt><dd><div id="ch2.apph.tab58_2"><p class="no_margin">SMD to MD conversion on CGAS scale using pooled SD for all studies using this scale (9.47517)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab58_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab58_4"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab58_5"><p class="no_margin">I<sup>2</sup> >33.3%</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab59"><div id="ch2.apph.tab59" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab59/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab59_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab59_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab59_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab59_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab59_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab59_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab59_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab59_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab59_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab59_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab59_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab59_1_1_1_1 hd_h_ch2.apph.tab59_1_1_1_2 hd_h_ch2.apph.tab59_1_1_1_3 hd_h_ch2.apph.tab59_1_1_1_4 hd_h_ch2.apph.tab59_1_1_1_5 hd_h_ch2.apph.tab59_1_1_1_6 hd_h_ch2.apph.tab59_1_1_1_7 hd_h_ch2.apph.tab59_1_1_1_8 hd_h_ch2.apph.tab59_1_1_1_9 hd_h_ch2.apph.tab59_1_1_1_10 hd_h_ch2.apph.tab59_1_1_1_11" id="hd_b_ch2.apph.tab59_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab59_1_1_1_1 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref16" rid="ch2.appo.ref16">Diamond 2002</a>)</td><td headers="hd_h_ch2.apph.tab59_1_1_1_2 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab59_1_1_1_3 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32</td><td headers="hd_h_ch2.apph.tab59_1_1_1_4 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.24</p>
|
|
<p>(−0.94, 0.45)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab59_1_1_1_5 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.08</p>
|
|
<p>(−8.15, 3.9)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab59_1_1_1_6 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab59_1_1_1_7 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab59_1_1_1_8 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab59_1_1_1_9 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab59_1_1_1_10 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab59_1_1_1_11 hd_b_ch2.apph.tab59_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab59_1_1_1_1 hd_h_ch2.apph.tab59_1_1_1_2 hd_h_ch2.apph.tab59_1_1_1_3 hd_h_ch2.apph.tab59_1_1_1_4 hd_h_ch2.apph.tab59_1_1_1_5 hd_h_ch2.apph.tab59_1_1_1_6 hd_h_ch2.apph.tab59_1_1_1_7 hd_h_ch2.apph.tab59_1_1_1_8 hd_h_ch2.apph.tab59_1_1_1_9 hd_h_ch2.apph.tab59_1_1_1_10 hd_h_ch2.apph.tab59_1_1_1_11" id="hd_b_ch2.apph.tab59_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab59_1_1_1_1 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref16" rid="ch2.appo.ref16">Diamond 2002</a>)</td><td headers="hd_h_ch2.apph.tab59_1_1_1_2 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab59_1_1_1_3 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32</td><td headers="hd_h_ch2.apph.tab59_1_1_1_4 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 3.00</p>
|
|
<p>(0.99, 9.08)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab59_1_1_1_5 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab59_1_1_1_6 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19 per 100</td><td headers="hd_h_ch2.apph.tab59_1_1_1_7 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>56 per 100</p>
|
|
<p>(19, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab59_1_1_1_8 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab59_1_1_1_9 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab59_1_1_1_10 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab59_1_1_1_11 hd_b_ch2.apph.tab59_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab59_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab59_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab59_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab60"><div id="ch2.apph.tab60" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab60/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab60_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab60_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab60_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab60_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab60_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab60_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab60_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab60_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab60_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab60_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab60_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab60_1_1_1_1 hd_h_ch2.apph.tab60_1_1_1_2 hd_h_ch2.apph.tab60_1_1_1_3 hd_h_ch2.apph.tab60_1_1_1_4 hd_h_ch2.apph.tab60_1_1_1_5 hd_h_ch2.apph.tab60_1_1_1_6 hd_h_ch2.apph.tab60_1_1_1_7 hd_h_ch2.apph.tab60_1_1_1_8 hd_h_ch2.apph.tab60_1_1_1_9 hd_h_ch2.apph.tab60_1_1_1_10 hd_h_ch2.apph.tab60_1_1_1_11" id="hd_b_ch2.apph.tab60_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms (values lower than 0 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab60_1_1_1_1 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref33" rid="ch2.appo.ref33">Israel 2013</a>, <a class="bibr" href="#ch2.appo.ref52" rid="ch2.appo.ref52">Poole 2018</a>)</td><td headers="hd_h_ch2.apph.tab60_1_1_1_2 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab60_1_1_1_3 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78</td><td headers="hd_h_ch2.apph.tab60_1_1_1_4 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.29</p>
|
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<p>(−0.74, 0.17)</p>
|
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</td><td headers="hd_h_ch2.apph.tab60_1_1_1_5 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−2.51</p>
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<p>(−6.41, 1.47)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab60_1_1_1_6 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab60_1_1_1_7 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab60_1_1_1_8 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab60_1_1_1_9 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab60_1_1_1_10 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab60_1_1_1_11 hd_b_ch2.apph.tab60_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab60_1_1_1_1 hd_h_ch2.apph.tab60_1_1_1_2 hd_h_ch2.apph.tab60_1_1_1_3 hd_h_ch2.apph.tab60_1_1_1_4 hd_h_ch2.apph.tab60_1_1_1_5 hd_h_ch2.apph.tab60_1_1_1_6 hd_h_ch2.apph.tab60_1_1_1_7 hd_h_ch2.apph.tab60_1_1_1_8 hd_h_ch2.apph.tab60_1_1_1_9 hd_h_ch2.apph.tab60_1_1_1_10 hd_h_ch2.apph.tab60_1_1_1_11" id="hd_b_ch2.apph.tab60_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, SMFQ (values lower than 0 favour family therapy) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab60_1_1_1_1 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref52" rid="ch2.appo.ref52">Poole 2018</a>)</td><td headers="hd_h_ch2.apph.tab60_1_1_1_2 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab60_1_1_1_3 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_ch2.apph.tab60_1_1_1_4 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD 0.02</p>
|
|
<p>(−0.47, 0.51)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab60_1_1_1_5 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
|
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<p>0.17</p>
|
|
<p>(−4.07, 4.42)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab60_1_1_1_6 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab60_1_1_1_7 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab60_1_1_1_8 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab60_1_1_1_9 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab60_1_1_1_10 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab60_1_1_1_11 hd_b_ch2.apph.tab60_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab60_1_1_1_1 hd_h_ch2.apph.tab60_1_1_1_2 hd_h_ch2.apph.tab60_1_1_1_3 hd_h_ch2.apph.tab60_1_1_1_4 hd_h_ch2.apph.tab60_1_1_1_5 hd_h_ch2.apph.tab60_1_1_1_6 hd_h_ch2.apph.tab60_1_1_1_7 hd_h_ch2.apph.tab60_1_1_1_8 hd_h_ch2.apph.tab60_1_1_1_9 hd_h_ch2.apph.tab60_1_1_1_10 hd_h_ch2.apph.tab60_1_1_1_11" id="hd_b_ch2.apph.tab60_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab60_1_1_1_1 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2 (<a class="bibr" href="#ch2.appo.ref33" rid="ch2.appo.ref33">Israel 2013</a>, <a class="bibr" href="#ch2.appo.ref52" rid="ch2.appo.ref52">Poole 2018</a>)</td><td headers="hd_h_ch2.apph.tab60_1_1_1_2 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCTs</td><td headers="hd_h_ch2.apph.tab60_1_1_1_3 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73</td><td headers="hd_h_ch2.apph.tab60_1_1_1_4 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.69</p>
|
|
<p>(0.22, 2.22)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab60_1_1_1_5 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab60_1_1_1_6 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 per 100</td><td headers="hd_h_ch2.apph.tab60_1_1_1_7 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>10 per 100</p>
|
|
<p>(3, 32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab60_1_1_1_8 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab60_1_1_1_9 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab60_1_1_1_10 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab60_1_1_1_11 hd_b_ch2.apph.tab60_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab60_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab60_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab60_3"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab61"><div id="ch2.apph.tab61" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab61/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab61_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab61_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab61_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab61_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab61_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab61_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: NDST</th><th id="hd_h_ch2.apph.tab61_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: family therapy (95% CI)</th><th id="hd_h_ch2.apph.tab61_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab61_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab61_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab61_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_h_ch2.apph.tab61_1_1_1_2 hd_h_ch2.apph.tab61_1_1_1_3 hd_h_ch2.apph.tab61_1_1_1_4 hd_h_ch2.apph.tab61_1_1_1_5 hd_h_ch2.apph.tab61_1_1_1_6 hd_h_ch2.apph.tab61_1_1_1_7 hd_h_ch2.apph.tab61_1_1_1_8 hd_h_ch2.apph.tab61_1_1_1_9 hd_h_ch2.apph.tab61_1_1_1_10 hd_h_ch2.apph.tab61_1_1_1_11" id="hd_b_ch2.apph.tab61_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab61_1_1_1_2 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab61_1_1_1_3 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53</td><td headers="hd_h_ch2.apph.tab61_1_1_1_4 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 2.00</p>
|
|
<p>(−2.29, 6.29)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_5 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab61_1_1_1_6 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab61_1_1_1_7 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab61_1_1_1_8 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_9 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab61_1_1_1_10 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_11 hd_b_ch2.apph.tab61_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_h_ch2.apph.tab61_1_1_1_2 hd_h_ch2.apph.tab61_1_1_1_3 hd_h_ch2.apph.tab61_1_1_1_4 hd_h_ch2.apph.tab61_1_1_1_5 hd_h_ch2.apph.tab61_1_1_1_6 hd_h_ch2.apph.tab61_1_1_1_7 hd_h_ch2.apph.tab61_1_1_1_8 hd_h_ch2.apph.tab61_1_1_1_9 hd_h_ch2.apph.tab61_1_1_1_10 hd_h_ch2.apph.tab61_1_1_1_11" id="hd_b_ch2.apph.tab61_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab61_1_1_1_2 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab61_1_1_1_3 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62</td><td headers="hd_h_ch2.apph.tab61_1_1_1_4 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.25</p>
|
|
<p>(−0.25, 0.75)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_5 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>2.17</p>
|
|
<p>(−2.17, 6.5)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_6 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab61_1_1_1_7 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab61_1_1_1_8 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_9 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab61_1_1_1_10 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_11 hd_b_ch2.apph.tab61_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_h_ch2.apph.tab61_1_1_1_2 hd_h_ch2.apph.tab61_1_1_1_3 hd_h_ch2.apph.tab61_1_1_1_4 hd_h_ch2.apph.tab61_1_1_1_5 hd_h_ch2.apph.tab61_1_1_1_6 hd_h_ch2.apph.tab61_1_1_1_7 hd_h_ch2.apph.tab61_1_1_1_8 hd_h_ch2.apph.tab61_1_1_1_9 hd_h_ch2.apph.tab61_1_1_1_10 hd_h_ch2.apph.tab61_1_1_1_11" id="hd_b_ch2.apph.tab61_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab61_1_1_1_2 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab61_1_1_1_3 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_ch2.apph.tab61_1_1_1_4 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.80</p>
|
|
<p>(0.39, 1.63)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_5 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab61_1_1_1_6 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36 per 100</td><td headers="hd_h_ch2.apph.tab61_1_1_1_7 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>29 per 100</p>
|
|
<p>(14, 59)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_8 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_9 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab61_1_1_1_10 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_11 hd_b_ch2.apph.tab61_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_h_ch2.apph.tab61_1_1_1_2 hd_h_ch2.apph.tab61_1_1_1_3 hd_h_ch2.apph.tab61_1_1_1_4 hd_h_ch2.apph.tab61_1_1_1_5 hd_h_ch2.apph.tab61_1_1_1_6 hd_h_ch2.apph.tab61_1_1_1_7 hd_h_ch2.apph.tab61_1_1_1_8 hd_h_ch2.apph.tab61_1_1_1_9 hd_h_ch2.apph.tab61_1_1_1_10 hd_h_ch2.apph.tab61_1_1_1_11" id="hd_b_ch2.apph.tab61_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation (values lower than 1 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab61_1_1_1_2 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab61_1_1_1_3 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_ch2.apph.tab61_1_1_1_4 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.43</p>
|
|
<p>(0.09, 2.04)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_5 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab61_1_1_1_6 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 per 100</td><td headers="hd_h_ch2.apph.tab61_1_1_1_7 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>7 per 100</p>
|
|
<p>(1, 31)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_8 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_9 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab61_1_1_1_10 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_11 hd_b_ch2.apph.tab61_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_h_ch2.apph.tab61_1_1_1_2 hd_h_ch2.apph.tab61_1_1_1_3 hd_h_ch2.apph.tab61_1_1_1_4 hd_h_ch2.apph.tab61_1_1_1_5 hd_h_ch2.apph.tab61_1_1_1_6 hd_h_ch2.apph.tab61_1_1_1_7 hd_h_ch2.apph.tab61_1_1_1_8 hd_h_ch2.apph.tab61_1_1_1_9 hd_h_ch2.apph.tab61_1_1_1_10 hd_h_ch2.apph.tab61_1_1_1_11" id="hd_b_ch2.apph.tab61_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour family therapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab61_1_1_1_1 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>)</td><td headers="hd_h_ch2.apph.tab61_1_1_1_2 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab61_1_1_1_3 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70</td><td headers="hd_h_ch2.apph.tab61_1_1_1_4 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.67</p>
|
|
<p>(0.12, 3.75)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_5 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab61_1_1_1_6 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9 per 100</td><td headers="hd_h_ch2.apph.tab61_1_1_1_7 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>6 per 100</p>
|
|
<p>(1, 32)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab61_1_1_1_8 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_9 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab61_1_1_1_10 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab61_1_1_1_11 hd_b_ch2.apph.tab61_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab61_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab61_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab61_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab62"><div id="ch2.apph.tab62" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab62/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab62_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab62_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab62_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab62_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab62_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab62_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab62_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: online guided self-help (95% CI)</th><th id="hd_h_ch2.apph.tab62_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab62_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab62_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab62_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab62_1_1_1_1 hd_h_ch2.apph.tab62_1_1_1_2 hd_h_ch2.apph.tab62_1_1_1_3 hd_h_ch2.apph.tab62_1_1_1_4 hd_h_ch2.apph.tab62_1_1_1_5 hd_h_ch2.apph.tab62_1_1_1_6 hd_h_ch2.apph.tab62_1_1_1_7 hd_h_ch2.apph.tab62_1_1_1_8 hd_h_ch2.apph.tab62_1_1_1_9 hd_h_ch2.apph.tab62_1_1_1_10 hd_h_ch2.apph.tab62_1_1_1_11" id="hd_b_ch2.apph.tab62_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS-R (values lower than 0 favour online guided self-help) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab62_1_1_1_1 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref56" rid="ch2.appo.ref56">Rickhi 2015</a>)</td><td headers="hd_h_ch2.apph.tab62_1_1_1_2 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab62_1_1_1_3 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31</td><td headers="hd_h_ch2.apph.tab62_1_1_1_4 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.87</p>
|
|
<p>(−1.62, −0.12)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab62_1_1_1_5 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−7.54</p>
|
|
<p>(−14.04, −1.04)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab62_1_1_1_6 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab62_1_1_1_7 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab62_1_1_1_8 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab62_1_1_1_9 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab62_1_1_1_10 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab62_1_1_1_11 hd_b_ch2.apph.tab62_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab62_1_1_1_1 hd_h_ch2.apph.tab62_1_1_1_2 hd_h_ch2.apph.tab62_1_1_1_3 hd_h_ch2.apph.tab62_1_1_1_4 hd_h_ch2.apph.tab62_1_1_1_5 hd_h_ch2.apph.tab62_1_1_1_6 hd_h_ch2.apph.tab62_1_1_1_7 hd_h_ch2.apph.tab62_1_1_1_8 hd_h_ch2.apph.tab62_1_1_1_9 hd_h_ch2.apph.tab62_1_1_1_10 hd_h_ch2.apph.tab62_1_1_1_11" id="hd_b_ch2.apph.tab62_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour online guided self-help) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab62_1_1_1_1 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref56" rid="ch2.appo.ref56">Rickhi 2015</a>)</td><td headers="hd_h_ch2.apph.tab62_1_1_1_2 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab62_1_1_1_3 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31</td><td headers="hd_h_ch2.apph.tab62_1_1_1_4 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 4.33</p>
|
|
<p>(0.59, 31.80)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab62_1_1_1_5 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab62_1_1_1_6 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8 per 100</td><td headers="hd_h_ch2.apph.tab62_1_1_1_7 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>33 per 100</p>
|
|
<p>(5, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab62_1_1_1_8 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab62_1_1_1_9 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab62_1_1_1_10 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab62_1_1_1_11 hd_b_ch2.apph.tab62_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab62_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab62_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab62_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab63"><div id="ch2.apph.tab63" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab63/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab63_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab63_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab63_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab63_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab63_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab63_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab63_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: IPT-A (95% CI)</th><th id="hd_h_ch2.apph.tab63_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab63_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab63_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab63_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab63_1_1_1_1 hd_h_ch2.apph.tab63_1_1_1_2 hd_h_ch2.apph.tab63_1_1_1_3 hd_h_ch2.apph.tab63_1_1_1_4 hd_h_ch2.apph.tab63_1_1_1_5 hd_h_ch2.apph.tab63_1_1_1_6 hd_h_ch2.apph.tab63_1_1_1_7 hd_h_ch2.apph.tab63_1_1_1_8 hd_h_ch2.apph.tab63_1_1_1_9 hd_h_ch2.apph.tab63_1_1_1_10 hd_h_ch2.apph.tab63_1_1_1_11" id="hd_b_ch2.apph.tab63_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab63_1_1_1_1 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rossello 1999</a>)</td><td headers="hd_h_ch2.apph.tab63_1_1_1_2 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab63_1_1_1_3 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_ch2.apph.tab63_1_1_1_4 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>MD −6.12</p>
|
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<p>(−10.48, 1.76)</p>
|
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</td><td headers="hd_h_ch2.apph.tab63_1_1_1_5 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab63_1_1_1_6 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab63_1_1_1_7 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab63_1_1_1_8 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab63_1_1_1_9 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab63_1_1_1_10 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab63_1_1_1_11 hd_b_ch2.apph.tab63_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab63_1_1_1_1 hd_h_ch2.apph.tab63_1_1_1_2 hd_h_ch2.apph.tab63_1_1_1_3 hd_h_ch2.apph.tab63_1_1_1_4 hd_h_ch2.apph.tab63_1_1_1_5 hd_h_ch2.apph.tab63_1_1_1_6 hd_h_ch2.apph.tab63_1_1_1_7 hd_h_ch2.apph.tab63_1_1_1_8 hd_h_ch2.apph.tab63_1_1_1_9 hd_h_ch2.apph.tab63_1_1_1_10 hd_h_ch2.apph.tab63_1_1_1_11" id="hd_b_ch2.apph.tab63_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab63_1_1_1_1 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rossello 1999</a>)</td><td headers="hd_h_ch2.apph.tab63_1_1_1_2 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab63_1_1_1_3 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46</td><td headers="hd_h_ch2.apph.tab63_1_1_1_4 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>RR 0.80</p>
|
|
<p>(0.25, 2.61)</p>
|
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</td><td headers="hd_h_ch2.apph.tab63_1_1_1_5 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab63_1_1_1_6 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22 per 100</td><td headers="hd_h_ch2.apph.tab63_1_1_1_7 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>17 per 100</p>
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<p>(5, 57)</p>
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</td><td headers="hd_h_ch2.apph.tab63_1_1_1_8 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab63_1_1_1_9 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab63_1_1_1_10 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab63_1_1_1_11 hd_b_ch2.apph.tab63_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab63_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab63_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab64"><div id="ch2.apph.tab64" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab64/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab64_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab64_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab64_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab64_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab64_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab64_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab64_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: IPT-A (95% CI)</th><th id="hd_h_ch2.apph.tab64_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab64_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab64_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab64_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab64_1_1_1_1 hd_h_ch2.apph.tab64_1_1_1_2 hd_h_ch2.apph.tab64_1_1_1_3 hd_h_ch2.apph.tab64_1_1_1_4 hd_h_ch2.apph.tab64_1_1_1_5 hd_h_ch2.apph.tab64_1_1_1_6 hd_h_ch2.apph.tab64_1_1_1_7 hd_h_ch2.apph.tab64_1_1_1_8 hd_h_ch2.apph.tab64_1_1_1_9 hd_h_ch2.apph.tab64_1_1_1_10 hd_h_ch2.apph.tab64_1_1_1_11" id="hd_b_ch2.apph.tab64_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab64_1_1_1_1 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref48" rid="ch2.appo.ref48">Mufson 1999</a>)</td><td headers="hd_h_ch2.apph.tab64_1_1_1_2 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab64_1_1_1_3 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch2.apph.tab64_1_1_1_4 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>SMD −0.29</p>
|
|
<p>(−0.86, 0.28)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab64_1_1_1_5 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.51</p>
|
|
<p>(−7.45, 2.43)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab64_1_1_1_6 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab64_1_1_1_7 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab64_1_1_1_8 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab64_1_1_1_9 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab64_1_1_1_10 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab64_1_1_1_11 hd_b_ch2.apph.tab64_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab64_1_1_1_1 hd_h_ch2.apph.tab64_1_1_1_2 hd_h_ch2.apph.tab64_1_1_1_3 hd_h_ch2.apph.tab64_1_1_1_4 hd_h_ch2.apph.tab64_1_1_1_5 hd_h_ch2.apph.tab64_1_1_1_6 hd_h_ch2.apph.tab64_1_1_1_7 hd_h_ch2.apph.tab64_1_1_1_8 hd_h_ch2.apph.tab64_1_1_1_9 hd_h_ch2.apph.tab64_1_1_1_10 hd_h_ch2.apph.tab64_1_1_1_11" id="hd_b_ch2.apph.tab64_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab64_1_1_1_1 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref48" rid="ch2.appo.ref48">Mufson 1999</a>)</td><td headers="hd_h_ch2.apph.tab64_1_1_1_2 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab64_1_1_1_3 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch2.apph.tab64_1_1_1_4 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.23</p>
|
|
<p>(0.08, 0.71)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab64_1_1_1_5 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab64_1_1_1_6 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54 per 100</td><td headers="hd_h_ch2.apph.tab64_1_1_1_7 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>12 per 100</p>
|
|
<p>(4, 38)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab64_1_1_1_8 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab64_1_1_1_9 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab64_1_1_1_10 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab64_1_1_1_11 hd_b_ch2.apph.tab64_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab64_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab64_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch2.apph.tab64_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab65"><div id="ch2.apph.tab65" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab65/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab65_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab65_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab65_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab65_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab65_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab65_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab65_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: IPT-A (95% CI)</th><th id="hd_h_ch2.apph.tab65_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab65_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab65_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab65_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab65_1_1_1_1 hd_h_ch2.apph.tab65_1_1_1_2 hd_h_ch2.apph.tab65_1_1_1_3 hd_h_ch2.apph.tab65_1_1_1_4 hd_h_ch2.apph.tab65_1_1_1_5 hd_h_ch2.apph.tab65_1_1_1_6 hd_h_ch2.apph.tab65_1_1_1_7 hd_h_ch2.apph.tab65_1_1_1_8 hd_h_ch2.apph.tab65_1_1_1_9 hd_h_ch2.apph.tab65_1_1_1_10 hd_h_ch2.apph.tab65_1_1_1_11" id="hd_b_ch2.apph.tab65_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab65_1_1_1_1 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>)</td><td headers="hd_h_ch2.apph.tab65_1_1_1_2 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab65_1_1_1_3 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58</td><td headers="hd_h_ch2.apph.tab65_1_1_1_4 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>MD 7.30</p>
|
|
<p>(1.37, 13.23)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab65_1_1_1_5 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab65_1_1_1_6 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab65_1_1_1_7 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab65_1_1_1_8 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab65_1_1_1_9 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab65_1_1_1_10 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab65_1_1_1_11 hd_b_ch2.apph.tab65_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab65_1_1_1_1 hd_h_ch2.apph.tab65_1_1_1_2 hd_h_ch2.apph.tab65_1_1_1_3 hd_h_ch2.apph.tab65_1_1_1_4 hd_h_ch2.apph.tab65_1_1_1_5 hd_h_ch2.apph.tab65_1_1_1_6 hd_h_ch2.apph.tab65_1_1_1_7 hd_h_ch2.apph.tab65_1_1_1_8 hd_h_ch2.apph.tab65_1_1_1_9 hd_h_ch2.apph.tab65_1_1_1_10 hd_h_ch2.apph.tab65_1_1_1_11" id="hd_b_ch2.apph.tab65_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI (values lower than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab65_1_1_1_1 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>)</td><td headers="hd_h_ch2.apph.tab65_1_1_1_2 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab65_1_1_1_3 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_ch2.apph.tab65_1_1_1_4 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.30</p>
|
|
<p>(−0.80, 0.20)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab65_1_1_1_5 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p><sup>*</sup>CDI scale</p>
|
|
<p>−2.6</p>
|
|
<p>(−6.93, 1.73)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab65_1_1_1_6 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab65_1_1_1_7 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab65_1_1_1_8 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab65_1_1_1_9 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab65_1_1_1_10 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab65_1_1_1_11 hd_b_ch2.apph.tab65_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab65_1_1_1_1 hd_h_ch2.apph.tab65_1_1_1_2 hd_h_ch2.apph.tab65_1_1_1_3 hd_h_ch2.apph.tab65_1_1_1_4 hd_h_ch2.apph.tab65_1_1_1_5 hd_h_ch2.apph.tab65_1_1_1_6 hd_h_ch2.apph.tab65_1_1_1_7 hd_h_ch2.apph.tab65_1_1_1_8 hd_h_ch2.apph.tab65_1_1_1_9 hd_h_ch2.apph.tab65_1_1_1_10 hd_h_ch2.apph.tab65_1_1_1_11" id="hd_b_ch2.apph.tab65_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour IPT-A)</th></tr><tr><td headers="hd_h_ch2.apph.tab65_1_1_1_1 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>)</td><td headers="hd_h_ch2.apph.tab65_1_1_1_2 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab65_1_1_1_3 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_ch2.apph.tab65_1_1_1_4 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.71</p>
|
|
<p>(0.34, 8.65)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab65_1_1_1_5 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab65_1_1_1_6 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7 per 100</td><td headers="hd_h_ch2.apph.tab65_1_1_1_7 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>12 per 100</p>
|
|
<p>(2, 60)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab65_1_1_1_8 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab65_1_1_1_9 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab65_1_1_1_10 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab65_1_1_1_11 hd_b_ch2.apph.tab65_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab65_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab65_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab65_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab66"><div id="ch2.apph.tab66" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab66/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab66_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab66_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab66_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab66_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab66_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab66_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: CBT</th><th id="hd_h_ch2.apph.tab66_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: IPT-A (95% CI)</th><th id="hd_h_ch2.apph.tab66_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab66_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab66_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab66_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab66_1_1_1_1 hd_h_ch2.apph.tab66_1_1_1_2 hd_h_ch2.apph.tab66_1_1_1_3 hd_h_ch2.apph.tab66_1_1_1_4 hd_h_ch2.apph.tab66_1_1_1_5 hd_h_ch2.apph.tab66_1_1_1_6 hd_h_ch2.apph.tab66_1_1_1_7 hd_h_ch2.apph.tab66_1_1_1_8 hd_h_ch2.apph.tab66_1_1_1_9 hd_h_ch2.apph.tab66_1_1_1_10 hd_h_ch2.apph.tab66_1_1_1_11" id="hd_b_ch2.apph.tab66_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab66_1_1_1_1 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rossello 1999</a>)</td><td headers="hd_h_ch2.apph.tab66_1_1_1_2 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab66_1_1_1_3 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_ch2.apph.tab66_1_1_1_4 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −3.58</p>
|
|
<p>(−8.04, 0.88)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab66_1_1_1_5 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab66_1_1_1_6 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab66_1_1_1_7 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab66_1_1_1_8 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab66_1_1_1_9 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab66_1_1_1_10 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab66_1_1_1_11 hd_b_ch2.apph.tab66_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab66_1_1_1_1 hd_h_ch2.apph.tab66_1_1_1_2 hd_h_ch2.apph.tab66_1_1_1_3 hd_h_ch2.apph.tab66_1_1_1_4 hd_h_ch2.apph.tab66_1_1_1_5 hd_h_ch2.apph.tab66_1_1_1_6 hd_h_ch2.apph.tab66_1_1_1_7 hd_h_ch2.apph.tab66_1_1_1_8 hd_h_ch2.apph.tab66_1_1_1_9 hd_h_ch2.apph.tab66_1_1_1_10 hd_h_ch2.apph.tab66_1_1_1_11" id="hd_b_ch2.apph.tab66_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDI (values lower than 0 favour IPT-A) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab66_1_1_1_1 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rossello 1999</a>)</td><td headers="hd_h_ch2.apph.tab66_1_1_1_2 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab66_1_1_1_3 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23</td><td headers="hd_h_ch2.apph.tab66_1_1_1_4 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 3.76</p>
|
|
<p>(−2.63, 10.15)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab66_1_1_1_5 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab66_1_1_1_6 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab66_1_1_1_7 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab66_1_1_1_8 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab66_1_1_1_9 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab66_1_1_1_10 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab66_1_1_1_11 hd_b_ch2.apph.tab66_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab66_1_1_1_1 hd_h_ch2.apph.tab66_1_1_1_2 hd_h_ch2.apph.tab66_1_1_1_3 hd_h_ch2.apph.tab66_1_1_1_4 hd_h_ch2.apph.tab66_1_1_1_5 hd_h_ch2.apph.tab66_1_1_1_6 hd_h_ch2.apph.tab66_1_1_1_7 hd_h_ch2.apph.tab66_1_1_1_8 hd_h_ch2.apph.tab66_1_1_1_9 hd_h_ch2.apph.tab66_1_1_1_10 hd_h_ch2.apph.tab66_1_1_1_11" id="hd_b_ch2.apph.tab66_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour IPT-A)</th></tr><tr><td headers="hd_h_ch2.apph.tab66_1_1_1_1 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rossello 1999</a>)</td><td headers="hd_h_ch2.apph.tab66_1_1_1_2 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab66_1_1_1_3 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_ch2.apph.tab66_1_1_1_4 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 1.09</p>
|
|
<p>(0.31, 3.85)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab66_1_1_1_5 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab66_1_1_1_6 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 per 100</td><td headers="hd_h_ch2.apph.tab66_1_1_1_7 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>17 per 100</p>
|
|
<p>(5, 62)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab66_1_1_1_8 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab66_1_1_1_9 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab66_1_1_1_10 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab66_1_1_1_11 hd_b_ch2.apph.tab66_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab66_1"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab66_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab67"><div id="ch2.apph.tab67" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab67/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab67_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab67_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab67_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab67_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab67_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab67_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: IPT-A + extra parents</th><th id="hd_h_ch2.apph.tab67_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: IPT-A (95% CI)</th><th id="hd_h_ch2.apph.tab67_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab67_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab67_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab67_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab67_1_1_1_1 hd_h_ch2.apph.tab67_1_1_1_2 hd_h_ch2.apph.tab67_1_1_1_3 hd_h_ch2.apph.tab67_1_1_1_4 hd_h_ch2.apph.tab67_1_1_1_5 hd_h_ch2.apph.tab67_1_1_1_6 hd_h_ch2.apph.tab67_1_1_1_7 hd_h_ch2.apph.tab67_1_1_1_8 hd_h_ch2.apph.tab67_1_1_1_9 hd_h_ch2.apph.tab67_1_1_1_10 hd_h_ch2.apph.tab67_1_1_1_11" id="hd_b_ch2.apph.tab67_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab67_1_1_1_1 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel 2016</a>)</td><td headers="hd_h_ch2.apph.tab67_1_1_1_2 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab67_1_1_1_3 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15</td><td headers="hd_h_ch2.apph.tab67_1_1_1_4 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −8.55</p>
|
|
<p>(−15.65, −1.45)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab67_1_1_1_5 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab67_1_1_1_6 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab67_1_1_1_7 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab67_1_1_1_8 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab67_1_1_1_9 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab67_1_1_1_10 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab67_1_1_1_11 hd_b_ch2.apph.tab67_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab67_1_1_1_1 hd_h_ch2.apph.tab67_1_1_1_2 hd_h_ch2.apph.tab67_1_1_1_3 hd_h_ch2.apph.tab67_1_1_1_4 hd_h_ch2.apph.tab67_1_1_1_5 hd_h_ch2.apph.tab67_1_1_1_6 hd_h_ch2.apph.tab67_1_1_1_7 hd_h_ch2.apph.tab67_1_1_1_8 hd_h_ch2.apph.tab67_1_1_1_9 hd_h_ch2.apph.tab67_1_1_1_10 hd_h_ch2.apph.tab67_1_1_1_11" id="hd_b_ch2.apph.tab67_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS-R (values lower than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab67_1_1_1_1 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel 2016</a>)</td><td headers="hd_h_ch2.apph.tab67_1_1_1_2 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab67_1_1_1_3 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15</td><td headers="hd_h_ch2.apph.tab67_1_1_1_4 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.53</p>
|
|
<p>(−0.53, 1.59)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab67_1_1_1_5 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>4.59</p>
|
|
<p>(−4.59, 13.78)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab67_1_1_1_6 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab67_1_1_1_7 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab67_1_1_1_8 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab67_1_1_1_9 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab67_1_1_1_10 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab67_1_1_1_11 hd_b_ch2.apph.tab67_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab67_1_1_1_1 hd_h_ch2.apph.tab67_1_1_1_2 hd_h_ch2.apph.tab67_1_1_1_3 hd_h_ch2.apph.tab67_1_1_1_4 hd_h_ch2.apph.tab67_1_1_1_5 hd_h_ch2.apph.tab67_1_1_1_6 hd_h_ch2.apph.tab67_1_1_1_7 hd_h_ch2.apph.tab67_1_1_1_8 hd_h_ch2.apph.tab67_1_1_1_9 hd_h_ch2.apph.tab67_1_1_1_10 hd_h_ch2.apph.tab67_1_1_1_11" id="hd_b_ch2.apph.tab67_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour IPT-A)</th></tr><tr><td headers="hd_h_ch2.apph.tab67_1_1_1_1 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel 2016</a>)</td><td headers="hd_h_ch2.apph.tab67_1_1_1_2 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab67_1_1_1_3 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15</td><td headers="hd_h_ch2.apph.tab67_1_1_1_4 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.29</p>
|
|
<p>(0.02, 5.08)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab67_1_1_1_5 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab67_1_1_1_6 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22 per 100</td><td headers="hd_h_ch2.apph.tab67_1_1_1_7 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>6 per 100</p>
|
|
<p>(0, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab67_1_1_1_8 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab67_1_1_1_9 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab67_1_1_1_10 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab67_1_1_1_11 hd_b_ch2.apph.tab67_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab67_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab67_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab67_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab68"><div id="ch2.apph.tab68" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab68/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab68_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab68_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab68_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab68_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab68_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab68_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: group IPT</th><th id="hd_h_ch2.apph.tab68_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: IPT-A (95% CI)</th><th id="hd_h_ch2.apph.tab68_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab68_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab68_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab68_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_h_ch2.apph.tab68_1_1_1_2 hd_h_ch2.apph.tab68_1_1_1_3 hd_h_ch2.apph.tab68_1_1_1_4 hd_h_ch2.apph.tab68_1_1_1_5 hd_h_ch2.apph.tab68_1_1_1_6 hd_h_ch2.apph.tab68_1_1_1_7 hd_h_ch2.apph.tab68_1_1_1_8 hd_h_ch2.apph.tab68_1_1_1_9 hd_h_ch2.apph.tab68_1_1_1_10 hd_h_ch2.apph.tab68_1_1_1_11" id="hd_b_ch2.apph.tab68_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>)</td><td headers="hd_h_ch2.apph.tab68_1_1_1_2 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab68_1_1_1_3 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch2.apph.tab68_1_1_1_4 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 6.95</p>
|
|
<p>(−2.37, 16.27)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_5 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_6 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_7 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_8 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_9 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab68_1_1_1_10 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_11 hd_b_ch2.apph.tab68_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_h_ch2.apph.tab68_1_1_1_2 hd_h_ch2.apph.tab68_1_1_1_3 hd_h_ch2.apph.tab68_1_1_1_4 hd_h_ch2.apph.tab68_1_1_1_5 hd_h_ch2.apph.tab68_1_1_1_6 hd_h_ch2.apph.tab68_1_1_1_7 hd_h_ch2.apph.tab68_1_1_1_8 hd_h_ch2.apph.tab68_1_1_1_9 hd_h_ch2.apph.tab68_1_1_1_10 hd_h_ch2.apph.tab68_1_1_1_11" id="hd_b_ch2.apph.tab68_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour IPT-A) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>)</td><td headers="hd_h_ch2.apph.tab68_1_1_1_2 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab68_1_1_1_3 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch2.apph.tab68_1_1_1_4 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −2.25</p>
|
|
<p>(−12.74, 8.24)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_5 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_6 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_7 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_8 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_9 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab68_1_1_1_10 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_11 hd_b_ch2.apph.tab68_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_h_ch2.apph.tab68_1_1_1_2 hd_h_ch2.apph.tab68_1_1_1_3 hd_h_ch2.apph.tab68_1_1_1_4 hd_h_ch2.apph.tab68_1_1_1_5 hd_h_ch2.apph.tab68_1_1_1_6 hd_h_ch2.apph.tab68_1_1_1_7 hd_h_ch2.apph.tab68_1_1_1_8 hd_h_ch2.apph.tab68_1_1_1_9 hd_h_ch2.apph.tab68_1_1_1_10 hd_h_ch2.apph.tab68_1_1_1_11" id="hd_b_ch2.apph.tab68_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI-II (values lower than 0 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>)</td><td headers="hd_h_ch2.apph.tab68_1_1_1_2 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab68_1_1_1_3 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch2.apph.tab68_1_1_1_4 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.03</p>
|
|
<p>(−0.66, 0.60)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_5 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−0.26</p>
|
|
<p>(−5.72, 5.2)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_6 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_7 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_8 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_9 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab68_1_1_1_10 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_11 hd_b_ch2.apph.tab68_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_h_ch2.apph.tab68_1_1_1_2 hd_h_ch2.apph.tab68_1_1_1_3 hd_h_ch2.apph.tab68_1_1_1_4 hd_h_ch2.apph.tab68_1_1_1_5 hd_h_ch2.apph.tab68_1_1_1_6 hd_h_ch2.apph.tab68_1_1_1_7 hd_h_ch2.apph.tab68_1_1_1_8 hd_h_ch2.apph.tab68_1_1_1_9 hd_h_ch2.apph.tab68_1_1_1_10 hd_h_ch2.apph.tab68_1_1_1_11" id="hd_b_ch2.apph.tab68_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, BDI-II (values lower than 0 favour IPT-A) - >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>)</td><td headers="hd_h_ch2.apph.tab68_1_1_1_2 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab68_1_1_1_3 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch2.apph.tab68_1_1_1_4 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD 0.29</p>
|
|
<p>(−0.34, 0.92)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_5 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>2.51</p>
|
|
<p>(−2.95, 7.97)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_6 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_7 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_8 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_9 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab68_1_1_1_10 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_11 hd_b_ch2.apph.tab68_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_h_ch2.apph.tab68_1_1_1_2 hd_h_ch2.apph.tab68_1_1_1_3 hd_h_ch2.apph.tab68_1_1_1_4 hd_h_ch2.apph.tab68_1_1_1_5 hd_h_ch2.apph.tab68_1_1_1_6 hd_h_ch2.apph.tab68_1_1_1_7 hd_h_ch2.apph.tab68_1_1_1_8 hd_h_ch2.apph.tab68_1_1_1_9 hd_h_ch2.apph.tab68_1_1_1_10 hd_h_ch2.apph.tab68_1_1_1_11" id="hd_b_ch2.apph.tab68_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour IPT-A) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>)</td><td headers="hd_h_ch2.apph.tab68_1_1_1_2 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab68_1_1_1_3 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch2.apph.tab68_1_1_1_4 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.82</p>
|
|
<p>(0.60, 1.11)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_5 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_6 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">90 per 100</td><td headers="hd_h_ch2.apph.tab68_1_1_1_7 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>74 per 100</p>
|
|
<p>(54, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_8 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_9 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab68_1_1_1_10 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_11 hd_b_ch2.apph.tab68_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_h_ch2.apph.tab68_1_1_1_2 hd_h_ch2.apph.tab68_1_1_1_3 hd_h_ch2.apph.tab68_1_1_1_4 hd_h_ch2.apph.tab68_1_1_1_5 hd_h_ch2.apph.tab68_1_1_1_6 hd_h_ch2.apph.tab68_1_1_1_7 hd_h_ch2.apph.tab68_1_1_1_8 hd_h_ch2.apph.tab68_1_1_1_9 hd_h_ch2.apph.tab68_1_1_1_10 hd_h_ch2.apph.tab68_1_1_1_11" id="hd_b_ch2.apph.tab68_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour IPT-A) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>)</td><td headers="hd_h_ch2.apph.tab68_1_1_1_2 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab68_1_1_1_3 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch2.apph.tab68_1_1_1_4 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.92</p>
|
|
<p>(0.65, 1.30)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_5 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_6 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80 per 100</td><td headers="hd_h_ch2.apph.tab68_1_1_1_7 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>74 per 100</p>
|
|
<p>(52, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_8 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_9 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab68_1_1_1_10 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_11 hd_b_ch2.apph.tab68_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_h_ch2.apph.tab68_1_1_1_2 hd_h_ch2.apph.tab68_1_1_1_3 hd_h_ch2.apph.tab68_1_1_1_4 hd_h_ch2.apph.tab68_1_1_1_5 hd_h_ch2.apph.tab68_1_1_1_6 hd_h_ch2.apph.tab68_1_1_1_7 hd_h_ch2.apph.tab68_1_1_1_8 hd_h_ch2.apph.tab68_1_1_1_9 hd_h_ch2.apph.tab68_1_1_1_10 hd_h_ch2.apph.tab68_1_1_1_11" id="hd_b_ch2.apph.tab68_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour IPT-A)</th></tr><tr><td headers="hd_h_ch2.apph.tab68_1_1_1_1 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>)</td><td headers="hd_h_ch2.apph.tab68_1_1_1_2 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab68_1_1_1_3 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_ch2.apph.tab68_1_1_1_4 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 7.37</p>
|
|
<p>(1.00, 54.39)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_5 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab68_1_1_1_6 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 per 100</td><td headers="hd_h_ch2.apph.tab68_1_1_1_7 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>37 per 100</p>
|
|
<p>(5, 100)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab68_1_1_1_8 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_9 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab68_1_1_1_10 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab68_1_1_1_11 hd_b_ch2.apph.tab68_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab68_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab68_2"><p class="no_margin">>33.3% of weighted data from studies at moderate or high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab68_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab69"><div id="ch2.apph.tab69" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab69/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab69_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab69_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab69_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab69_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab69_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab69_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: psychosocial intervention</th><th id="hd_h_ch2.apph.tab69_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: Psychodynamic psychotherapy (95% CI)</th><th id="hd_h_ch2.apph.tab69_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab69_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab69_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab69_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_h_ch2.apph.tab69_1_1_1_2 hd_h_ch2.apph.tab69_1_1_1_3 hd_h_ch2.apph.tab69_1_1_1_4 hd_h_ch2.apph.tab69_1_1_1_5 hd_h_ch2.apph.tab69_1_1_1_6 hd_h_ch2.apph.tab69_1_1_1_7 hd_h_ch2.apph.tab69_1_1_1_8 hd_h_ch2.apph.tab69_1_1_1_9 hd_h_ch2.apph.tab69_1_1_1_10 hd_h_ch2.apph.tab69_1_1_1_11" id="hd_b_ch2.apph.tab69_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour psychodynamic psychotherapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab69_1_1_1_2 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab69_1_1_1_3 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">214</td><td headers="hd_h_ch2.apph.tab69_1_1_1_4 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.22</p>
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<p>(−0.49, 0.05)</p>
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</td><td headers="hd_h_ch2.apph.tab69_1_1_1_5 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−1.91</p>
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<p>(−4.25, 0.43)</p>
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</td><td headers="hd_h_ch2.apph.tab69_1_1_1_6 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_7 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_8 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_9 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_10 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab69_1_1_1_11 hd_b_ch2.apph.tab69_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_h_ch2.apph.tab69_1_1_1_2 hd_h_ch2.apph.tab69_1_1_1_3 hd_h_ch2.apph.tab69_1_1_1_4 hd_h_ch2.apph.tab69_1_1_1_5 hd_h_ch2.apph.tab69_1_1_1_6 hd_h_ch2.apph.tab69_1_1_1_7 hd_h_ch2.apph.tab69_1_1_1_8 hd_h_ch2.apph.tab69_1_1_1_9 hd_h_ch2.apph.tab69_1_1_1_10 hd_h_ch2.apph.tab69_1_1_1_11" id="hd_b_ch2.apph.tab69_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour psychodynamic psychotherapy) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab69_1_1_1_2 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab69_1_1_1_3 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">115</td><td headers="hd_h_ch2.apph.tab69_1_1_1_4 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.09</p>
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<p>(−0.36, 0.18)</p>
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</td><td headers="hd_h_ch2.apph.tab69_1_1_1_5 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−0.78</p>
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<p>(−3.12, 1.56)</p>
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</td><td headers="hd_h_ch2.apph.tab69_1_1_1_6 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_7 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_8 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_9 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_10 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab69_1_1_1_11 hd_b_ch2.apph.tab69_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_h_ch2.apph.tab69_1_1_1_2 hd_h_ch2.apph.tab69_1_1_1_3 hd_h_ch2.apph.tab69_1_1_1_4 hd_h_ch2.apph.tab69_1_1_1_5 hd_h_ch2.apph.tab69_1_1_1_6 hd_h_ch2.apph.tab69_1_1_1_7 hd_h_ch2.apph.tab69_1_1_1_8 hd_h_ch2.apph.tab69_1_1_1_9 hd_h_ch2.apph.tab69_1_1_1_10 hd_h_ch2.apph.tab69_1_1_1_11" id="hd_b_ch2.apph.tab69_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, MFQ (values lower than 0 favour psychodynamic psychotherapy), >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab69_1_1_1_2 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab69_1_1_1_3 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">130</td><td headers="hd_h_ch2.apph.tab69_1_1_1_4 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>SMD −0.07</p>
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<p>(−0.33, 0.19)</p>
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</td><td headers="hd_h_ch2.apph.tab69_1_1_1_5 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p><sup>*</sup>CDI scale</p>
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<p>−0.61</p>
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<p>(−2.86, 1.65)</p>
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|
</td><td headers="hd_h_ch2.apph.tab69_1_1_1_6 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_7 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_8 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_9 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_10 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab69_1_1_1_11 hd_b_ch2.apph.tab69_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_h_ch2.apph.tab69_1_1_1_2 hd_h_ch2.apph.tab69_1_1_1_3 hd_h_ch2.apph.tab69_1_1_1_4 hd_h_ch2.apph.tab69_1_1_1_5 hd_h_ch2.apph.tab69_1_1_1_6 hd_h_ch2.apph.tab69_1_1_1_7 hd_h_ch2.apph.tab69_1_1_1_8 hd_h_ch2.apph.tab69_1_1_1_9 hd_h_ch2.apph.tab69_1_1_1_10 hd_h_ch2.apph.tab69_1_1_1_11" id="hd_b_ch2.apph.tab69_1_1_7_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Remission (values higher than 1 favour psychodynamic psychotherapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab69_1_1_1_2 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab69_1_1_1_3 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">315</td><td headers="hd_h_ch2.apph.tab69_1_1_1_4 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>RR 1.01</p>
|
|
<p>(0.72, 1.40)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab69_1_1_1_5 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_6 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30 per 100</td><td headers="hd_h_ch2.apph.tab69_1_1_1_7 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>31 per 100</p>
|
|
<p>(22, 43)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab69_1_1_1_8 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_9 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_10 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab69_1_1_1_11 hd_b_ch2.apph.tab69_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_h_ch2.apph.tab69_1_1_1_2 hd_h_ch2.apph.tab69_1_1_1_3 hd_h_ch2.apph.tab69_1_1_1_4 hd_h_ch2.apph.tab69_1_1_1_5 hd_h_ch2.apph.tab69_1_1_1_6 hd_h_ch2.apph.tab69_1_1_1_7 hd_h_ch2.apph.tab69_1_1_1_8 hd_h_ch2.apph.tab69_1_1_1_9 hd_h_ch2.apph.tab69_1_1_1_10 hd_h_ch2.apph.tab69_1_1_1_11" id="hd_b_ch2.apph.tab69_1_1_9_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of Life, HoNOSCA (values lower than 1 favour psychodynamic psychotherapy) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab69_1_1_1_2 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab69_1_1_1_3 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">176</td><td headers="hd_h_ch2.apph.tab69_1_1_1_4 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD −1.00</p>
|
|
<p>(−3.18, 1.18)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab69_1_1_1_5 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_6 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_7 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_8 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_9 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_10 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab69_1_1_1_11 hd_b_ch2.apph.tab69_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_h_ch2.apph.tab69_1_1_1_2 hd_h_ch2.apph.tab69_1_1_1_3 hd_h_ch2.apph.tab69_1_1_1_4 hd_h_ch2.apph.tab69_1_1_1_5 hd_h_ch2.apph.tab69_1_1_1_6 hd_h_ch2.apph.tab69_1_1_1_7 hd_h_ch2.apph.tab69_1_1_1_8 hd_h_ch2.apph.tab69_1_1_1_9 hd_h_ch2.apph.tab69_1_1_1_10 hd_h_ch2.apph.tab69_1_1_1_11" id="hd_b_ch2.apph.tab69_1_1_11_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of Life, HoNOSCA (values lower than 1 favour psychodynamic psychotherapy) – ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab69_1_1_1_2 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab69_1_1_1_3 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">171</td><td headers="hd_h_ch2.apph.tab69_1_1_1_4 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>MD −0.20</p>
|
|
<p>(−2.08, 1.68)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab69_1_1_1_5 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_6 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_7 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_8 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_9 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_10 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab69_1_1_1_11 hd_b_ch2.apph.tab69_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_h_ch2.apph.tab69_1_1_1_2 hd_h_ch2.apph.tab69_1_1_1_3 hd_h_ch2.apph.tab69_1_1_1_4 hd_h_ch2.apph.tab69_1_1_1_5 hd_h_ch2.apph.tab69_1_1_1_6 hd_h_ch2.apph.tab69_1_1_1_7 hd_h_ch2.apph.tab69_1_1_1_8 hd_h_ch2.apph.tab69_1_1_1_9 hd_h_ch2.apph.tab69_1_1_1_10 hd_h_ch2.apph.tab69_1_1_1_11" id="hd_b_ch2.apph.tab69_1_1_13_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of Life, HoNOSCA (values lower than 1 favour psychodynamic psychotherapy) – >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab69_1_1_1_2 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab69_1_1_1_3 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">183</td><td headers="hd_h_ch2.apph.tab69_1_1_1_4 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 0.70</p>
|
|
<p>(−1.18, 2.58)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab69_1_1_1_5 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_6 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_7 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_8 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_9 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_10 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab69_1_1_1_11 hd_b_ch2.apph.tab69_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr><tr><th headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_h_ch2.apph.tab69_1_1_1_2 hd_h_ch2.apph.tab69_1_1_1_3 hd_h_ch2.apph.tab69_1_1_1_4 hd_h_ch2.apph.tab69_1_1_1_5 hd_h_ch2.apph.tab69_1_1_1_6 hd_h_ch2.apph.tab69_1_1_1_7 hd_h_ch2.apph.tab69_1_1_1_8 hd_h_ch2.apph.tab69_1_1_1_9 hd_h_ch2.apph.tab69_1_1_1_10 hd_h_ch2.apph.tab69_1_1_1_11" id="hd_b_ch2.apph.tab69_1_1_15_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour psychodynamic psychotherapy)</th></tr><tr><td headers="hd_h_ch2.apph.tab69_1_1_1_1 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td><td headers="hd_h_ch2.apph.tab69_1_1_1_2 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab69_1_1_1_3 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">283</td><td headers="hd_h_ch2.apph.tab69_1_1_1_4 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.77</p>
|
|
<p>(0.43, 1.36)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab69_1_1_1_5 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab69_1_1_1_6 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16 per 100</td><td headers="hd_h_ch2.apph.tab69_1_1_1_7 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>13 per 100</p>
|
|
<p>(7, 22)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab69_1_1_1_8 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_9 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab69_1_1_1_10 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>1</sup></td><td headers="hd_h_ch2.apph.tab69_1_1_1_11 hd_b_ch2.apph.tab69_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">High</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab69_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab69_2"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab70"><div id="ch2.apph.tab70" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab70/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab70_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab70_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab70_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab70_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Effect size (95% CI)</th><th id="hd_h_ch2.apph.tab70_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">SMD to MD conversion</th><th id="hd_h_ch2.apph.tab70_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: control</th><th id="hd_h_ch2.apph.tab70_1_1_1_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute risk: intervention (95% CI)</th><th id="hd_h_ch2.apph.tab70_1_1_1_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab70_1_1_1_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab70_1_1_1_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab70_1_1_1_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab70_1_1_1_1 hd_h_ch2.apph.tab70_1_1_1_2 hd_h_ch2.apph.tab70_1_1_1_3 hd_h_ch2.apph.tab70_1_1_1_4 hd_h_ch2.apph.tab70_1_1_1_5 hd_h_ch2.apph.tab70_1_1_1_6 hd_h_ch2.apph.tab70_1_1_1_7 hd_h_ch2.apph.tab70_1_1_1_8 hd_h_ch2.apph.tab70_1_1_1_9 hd_h_ch2.apph.tab70_1_1_1_10 hd_h_ch2.apph.tab70_1_1_1_11" id="hd_b_ch2.apph.tab70_1_1_1_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, CGAS (values higher than 0 favour behavioural activation) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab70_1_1_1_1 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref46" rid="ch2.appo.ref46">McCauley 2016</a>)</td><td headers="hd_h_ch2.apph.tab70_1_1_1_2 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab70_1_1_1_3 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60</td><td headers="hd_h_ch2.apph.tab70_1_1_1_4 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>MD 3.00</p>
|
|
<p>(−2.61, 8.61)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab70_1_1_1_5 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab70_1_1_1_6 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab70_1_1_1_7 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab70_1_1_1_8 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab70_1_1_1_9 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab70_1_1_1_10 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab70_1_1_1_11 hd_b_ch2.apph.tab70_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab70_1_1_1_1 hd_h_ch2.apph.tab70_1_1_1_2 hd_h_ch2.apph.tab70_1_1_1_3 hd_h_ch2.apph.tab70_1_1_1_4 hd_h_ch2.apph.tab70_1_1_1_5 hd_h_ch2.apph.tab70_1_1_1_6 hd_h_ch2.apph.tab70_1_1_1_7 hd_h_ch2.apph.tab70_1_1_1_8 hd_h_ch2.apph.tab70_1_1_1_9 hd_h_ch2.apph.tab70_1_1_1_10 hd_h_ch2.apph.tab70_1_1_1_11" id="hd_b_ch2.apph.tab70_1_1_3_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, CDRS-R (values lower than 0 favour behavioural activation) – Post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab70_1_1_1_1 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref46" rid="ch2.appo.ref46">McCauley 2016</a>)</td><td headers="hd_h_ch2.apph.tab70_1_1_1_2 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab70_1_1_1_3 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60</td><td headers="hd_h_ch2.apph.tab70_1_1_1_4 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>SMD −0.36</p>
|
|
<p>(−0.88, 0.15)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab70_1_1_1_5 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p><sup>*</sup>CDI scale</p>
|
|
<p>−3.12</p>
|
|
<p>(−7.63, 1.3)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab70_1_1_1_6 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab70_1_1_1_7 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab70_1_1_1_8 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab70_1_1_1_9 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab70_1_1_1_10 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab70_1_1_1_11 hd_b_ch2.apph.tab70_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab70_1_1_1_1 hd_h_ch2.apph.tab70_1_1_1_2 hd_h_ch2.apph.tab70_1_1_1_3 hd_h_ch2.apph.tab70_1_1_1_4 hd_h_ch2.apph.tab70_1_1_1_5 hd_h_ch2.apph.tab70_1_1_1_6 hd_h_ch2.apph.tab70_1_1_1_7 hd_h_ch2.apph.tab70_1_1_1_8 hd_h_ch2.apph.tab70_1_1_1_9 hd_h_ch2.apph.tab70_1_1_1_10 hd_h_ch2.apph.tab70_1_1_1_11" id="hd_b_ch2.apph.tab70_1_1_5_1" colspan="11" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason (values lower than 1 favour behavioural activation)</th></tr><tr><td headers="hd_h_ch2.apph.tab70_1_1_1_1 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 (<a class="bibr" href="#ch2.appo.ref46" rid="ch2.appo.ref46">McCauley 2016</a>)</td><td headers="hd_h_ch2.apph.tab70_1_1_1_2 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCT</td><td headers="hd_h_ch2.apph.tab70_1_1_1_3 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53</td><td headers="hd_h_ch2.apph.tab70_1_1_1_4 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>RR 0.21</p>
|
|
<p>(0.05, 0.88)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab70_1_1_1_5 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.apph.tab70_1_1_1_6 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33 per 100</td><td headers="hd_h_ch2.apph.tab70_1_1_1_7 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>7 per 100</p>
|
|
<p>(2, 29)</p>
|
|
</td><td headers="hd_h_ch2.apph.tab70_1_1_1_8 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Very serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab70_1_1_1_9 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not serious</td><td headers="hd_h_ch2.apph.tab70_1_1_1_10 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N/A<sup>2</sup></td><td headers="hd_h_ch2.apph.tab70_1_1_1_11 hd_b_ch2.apph.tab70_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab70_1"><p class="no_margin">SMD to MD conversion on CDI scale using pooled SD for all studies using this scale (8.6663)</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab70_2"><p class="no_margin">>33.3% of weighted data from studies at high risk of bias</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab70_3"><p class="no_margin">Only one study so inconsistency not applicable</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab71"><div id="ch2.apph.tab71" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab71/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab71_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab71_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab71_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab71_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Effect estimates</th><th id="hd_h_ch2.apph.tab71_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab71_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab71_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab71_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_h_ch2.apph.tab71_1_1_1_2 hd_h_ch2.apph.tab71_1_1_1_3 hd_h_ch2.apph.tab71_1_1_1_4 hd_h_ch2.apph.tab71_1_1_1_5 hd_h_ch2.apph.tab71_1_1_1_6 hd_h_ch2.apph.tab71_1_1_1_7 hd_h_ch2.apph.tab71_1_1_1_8" id="hd_b_ch2.apph.tab71_1_1_1_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_b_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">26</td><td headers="hd_h_ch2.apph.tab71_1_1_1_2 hd_b_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab71_1_1_1_3 hd_b_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3,206</td><td headers="hd_h_ch2.apph.tab71_1_1_1_4 hd_b_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab71_1_1_1_5 hd_b_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_6 hd_b_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab71_1_1_1_7 hd_b_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Very serious<sup>2</sup><sup>,</sup><sup>3</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_8 hd_b_ch2.apph.tab71_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_h_ch2.apph.tab71_1_1_1_2 hd_h_ch2.apph.tab71_1_1_1_3 hd_h_ch2.apph.tab71_1_1_1_4 hd_h_ch2.apph.tab71_1_1_1_5 hd_h_ch2.apph.tab71_1_1_1_6 hd_h_ch2.apph.tab71_1_1_1_7 hd_h_ch2.apph.tab71_1_1_1_8" id="hd_b_ch2.apph.tab71_1_1_3_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_b_ch2.apph.tab71_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">22</td><td headers="hd_h_ch2.apph.tab71_1_1_1_2 hd_b_ch2.apph.tab71_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab71_1_1_1_3 hd_b_ch2.apph.tab71_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2,885</td><td headers="hd_h_ch2.apph.tab71_1_1_1_4 hd_b_ch2.apph.tab71_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab71_1_1_1_5 hd_b_ch2.apph.tab71_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_6 hd_b_ch2.apph.tab71_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab71_1_1_1_7 hd_b_ch2.apph.tab71_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>4</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_8 hd_b_ch2.apph.tab71_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_h_ch2.apph.tab71_1_1_1_2 hd_h_ch2.apph.tab71_1_1_1_3 hd_h_ch2.apph.tab71_1_1_1_4 hd_h_ch2.apph.tab71_1_1_1_5 hd_h_ch2.apph.tab71_1_1_1_6 hd_h_ch2.apph.tab71_1_1_1_7 hd_h_ch2.apph.tab71_1_1_1_8" id="hd_b_ch2.apph.tab71_1_1_5_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_b_ch2.apph.tab71_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">9</td><td headers="hd_h_ch2.apph.tab71_1_1_1_2 hd_b_ch2.apph.tab71_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab71_1_1_1_3 hd_b_ch2.apph.tab71_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1,417</td><td headers="hd_h_ch2.apph.tab71_1_1_1_4 hd_b_ch2.apph.tab71_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab71_1_1_1_5 hd_b_ch2.apph.tab71_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_6 hd_b_ch2.apph.tab71_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab71_1_1_1_7 hd_b_ch2.apph.tab71_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab71_1_1_1_8 hd_b_ch2.apph.tab71_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_h_ch2.apph.tab71_1_1_1_2 hd_h_ch2.apph.tab71_1_1_1_3 hd_h_ch2.apph.tab71_1_1_1_4 hd_h_ch2.apph.tab71_1_1_1_5 hd_h_ch2.apph.tab71_1_1_1_6 hd_h_ch2.apph.tab71_1_1_1_7 hd_h_ch2.apph.tab71_1_1_1_8" id="hd_b_ch2.apph.tab71_1_1_7_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Remission, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_b_ch2.apph.tab71_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.apph.tab71_1_1_1_2 hd_b_ch2.apph.tab71_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab71_1_1_1_3 hd_b_ch2.apph.tab71_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">87</td><td headers="hd_h_ch2.apph.tab71_1_1_1_4 hd_b_ch2.apph.tab71_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab71_1_1_1_5 hd_b_ch2.apph.tab71_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Very serious<sup>4</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_6 hd_b_ch2.apph.tab71_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab71_1_1_1_7 hd_b_ch2.apph.tab71_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>4</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_8 hd_b_ch2.apph.tab71_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_h_ch2.apph.tab71_1_1_1_2 hd_h_ch2.apph.tab71_1_1_1_3 hd_h_ch2.apph.tab71_1_1_1_4 hd_h_ch2.apph.tab71_1_1_1_5 hd_h_ch2.apph.tab71_1_1_1_6 hd_h_ch2.apph.tab71_1_1_1_7 hd_h_ch2.apph.tab71_1_1_1_8" id="hd_b_ch2.apph.tab71_1_1_9_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason</th></tr><tr><td headers="hd_h_ch2.apph.tab71_1_1_1_1 hd_b_ch2.apph.tab71_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">22</td><td headers="hd_h_ch2.apph.tab71_1_1_1_2 hd_b_ch2.apph.tab71_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab71_1_1_1_3 hd_b_ch2.apph.tab71_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3,971</td><td headers="hd_h_ch2.apph.tab71_1_1_1_4 hd_b_ch2.apph.tab71_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab71_1_1_1_5 hd_b_ch2.apph.tab71_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_6 hd_b_ch2.apph.tab71_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab71_1_1_1_7 hd_b_ch2.apph.tab71_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab71_1_1_1_8 hd_b_ch2.apph.tab71_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Low</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab71_1"><p class="no_margin">>33.3% of studies in the NMA at moderate or high risk of bias.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab71_2"><p class="no_margin">Meaningful differences between point estimates from direct and indirect evidence.</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab71_3"><p class="no_margin">DIC for a random-effects model lower than the DIC for a fixed-effects model.</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="ch2.apph.tab71_4"><p class="no_margin">>33.3% of studies in the NMA at high risk of bias.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab72"><div id="ch2.apph.tab72" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab72/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab72_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab72_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab72_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab72_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Effect estimates</th><th id="hd_h_ch2.apph.tab72_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab72_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab72_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab72_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab72_1_1_1_1 hd_h_ch2.apph.tab72_1_1_1_2 hd_h_ch2.apph.tab72_1_1_1_3 hd_h_ch2.apph.tab72_1_1_1_4 hd_h_ch2.apph.tab72_1_1_1_5 hd_h_ch2.apph.tab72_1_1_1_6 hd_h_ch2.apph.tab72_1_1_1_7 hd_h_ch2.apph.tab72_1_1_1_8" id="hd_b_ch2.apph.tab72_1_1_1_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab72_1_1_1_1 hd_b_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.apph.tab72_1_1_1_2 hd_b_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab72_1_1_1_3 hd_b_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">244</td><td headers="hd_h_ch2.apph.tab72_1_1_1_4 hd_b_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab72_1_1_1_5 hd_b_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab72_1_1_1_6 hd_b_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab72_1_1_1_7 hd_b_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab72_1_1_1_8 hd_b_ch2.apph.tab72_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab72_1_1_1_1 hd_h_ch2.apph.tab72_1_1_1_2 hd_h_ch2.apph.tab72_1_1_1_3 hd_h_ch2.apph.tab72_1_1_1_4 hd_h_ch2.apph.tab72_1_1_1_5 hd_h_ch2.apph.tab72_1_1_1_6 hd_h_ch2.apph.tab72_1_1_1_7 hd_h_ch2.apph.tab72_1_1_1_8" id="hd_b_ch2.apph.tab72_1_1_3_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab72_1_1_1_1 hd_b_ch2.apph.tab72_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.apph.tab72_1_1_1_2 hd_b_ch2.apph.tab72_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab72_1_1_1_3 hd_b_ch2.apph.tab72_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">206</td><td headers="hd_h_ch2.apph.tab72_1_1_1_4 hd_b_ch2.apph.tab72_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab72_1_1_1_5 hd_b_ch2.apph.tab72_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab72_1_1_1_6 hd_b_ch2.apph.tab72_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab72_1_1_1_7 hd_b_ch2.apph.tab72_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>2</sup></td><td headers="hd_h_ch2.apph.tab72_1_1_1_8 hd_b_ch2.apph.tab72_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab72_1_1_1_1 hd_h_ch2.apph.tab72_1_1_1_2 hd_h_ch2.apph.tab72_1_1_1_3 hd_h_ch2.apph.tab72_1_1_1_4 hd_h_ch2.apph.tab72_1_1_1_5 hd_h_ch2.apph.tab72_1_1_1_6 hd_h_ch2.apph.tab72_1_1_1_7 hd_h_ch2.apph.tab72_1_1_1_8" id="hd_b_ch2.apph.tab72_1_1_5_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Remission, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab72_1_1_1_1 hd_b_ch2.apph.tab72_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.apph.tab72_1_1_1_2 hd_b_ch2.apph.tab72_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab72_1_1_1_3 hd_b_ch2.apph.tab72_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">244</td><td headers="hd_h_ch2.apph.tab72_1_1_1_4 hd_b_ch2.apph.tab72_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab72_1_1_1_5 hd_b_ch2.apph.tab72_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab72_1_1_1_6 hd_b_ch2.apph.tab72_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab72_1_1_1_7 hd_b_ch2.apph.tab72_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab72_1_1_1_8 hd_b_ch2.apph.tab72_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab72_1_1_1_1 hd_h_ch2.apph.tab72_1_1_1_2 hd_h_ch2.apph.tab72_1_1_1_3 hd_h_ch2.apph.tab72_1_1_1_4 hd_h_ch2.apph.tab72_1_1_1_5 hd_h_ch2.apph.tab72_1_1_1_6 hd_h_ch2.apph.tab72_1_1_1_7 hd_h_ch2.apph.tab72_1_1_1_8" id="hd_b_ch2.apph.tab72_1_1_7_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason, end point</th></tr><tr><td headers="hd_h_ch2.apph.tab72_1_1_1_1 hd_b_ch2.apph.tab72_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.apph.tab72_1_1_1_2 hd_b_ch2.apph.tab72_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab72_1_1_1_3 hd_b_ch2.apph.tab72_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">246</td><td headers="hd_h_ch2.apph.tab72_1_1_1_4 hd_b_ch2.apph.tab72_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab72_1_1_1_5 hd_b_ch2.apph.tab72_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab72_1_1_1_6 hd_b_ch2.apph.tab72_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab72_1_1_1_7 hd_b_ch2.apph.tab72_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab72_1_1_1_8 hd_b_ch2.apph.tab72_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab72_1"><p class="no_margin">>33.3% of studies in the NMA at moderate or high risk of bias.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab72_2"><p class="no_margin">DIC for a random-effects model lower than the DIC for a fixed-effects model.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2apphtab73"><div id="ch2.apph.tab73" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apph.tab73/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apph.tab73_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">No. of studies</th><th id="hd_h_ch2.apph.tab73_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Study design</th><th id="hd_h_ch2.apph.tab73_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Sample size</th><th id="hd_h_ch2.apph.tab73_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Effect estimates</th><th id="hd_h_ch2.apph.tab73_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Risk of bias</th><th id="hd_h_ch2.apph.tab73_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Indirectness</th><th id="hd_h_ch2.apph.tab73_1_1_1_7" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Inconsistency</th><th id="hd_h_ch2.apph.tab73_1_1_1_8" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">Quality</th></tr></thead><tbody><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_1_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">22</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1,886</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Very serious<sup>2</sup><sup>,</sup><sup>3</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Very low</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_3_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">703</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_5_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Depression symptoms, >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">706</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_7_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">9</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">926</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_9_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">260</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_11_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Functional status, >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">285</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_13_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Remission, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">8</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">875</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_15_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">632</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_17_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, ≤6 months</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">469</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>3</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Low</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_19_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Quality of life, >6 to ≤18 months</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">487</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_21_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Suicide ideation (dichotomous), post-treatment</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">3<sup>*</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">534</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr><tr><th headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_h_ch2.apph.tab73_1_1_1_2 hd_h_ch2.apph.tab73_1_1_1_3 hd_h_ch2.apph.tab73_1_1_1_4 hd_h_ch2.apph.tab73_1_1_1_5 hd_h_ch2.apph.tab73_1_1_1_6 hd_h_ch2.apph.tab73_1_1_1_7 hd_h_ch2.apph.tab73_1_1_1_8" id="hd_b_ch2.apph.tab73_1_1_23_1" colspan="8" rowspan="1" style="text-align:left;vertical-align:middle;">Discontinuation for any reason, end point</th></tr><tr><td headers="hd_h_ch2.apph.tab73_1_1_1_1 hd_b_ch2.apph.tab73_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">18</td><td headers="hd_h_ch2.apph.tab73_1_1_1_2 hd_b_ch2.apph.tab73_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">RCT</td><td headers="hd_h_ch2.apph.tab73_1_1_1_3 hd_b_ch2.apph.tab73_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1,886</td><td headers="hd_h_ch2.apph.tab73_1_1_1_4 hd_b_ch2.apph.tab73_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">See <a href="#ch2.appg">appendix G</a></td><td headers="hd_h_ch2.apph.tab73_1_1_1_5 hd_b_ch2.apph.tab73_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Serious<sup>1</sup></td><td headers="hd_h_ch2.apph.tab73_1_1_1_6 hd_b_ch2.apph.tab73_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_7 hd_b_ch2.apph.tab73_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Not serious</td><td headers="hd_h_ch2.apph.tab73_1_1_1_8 hd_b_ch2.apph.tab73_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Moderate</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apph.tab73_1"><p class="no_margin">Studies with zero events in both arms removed from analysis.</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="ch2.apph.tab73_2"><p class="no_margin">>33.3% of studies in the NMA at moderate or high risk of bias.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="ch2.apph.tab73_3"><p class="no_margin">Meaningful differences between point estimates from direct and indirect evidence.</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="ch2.apph.tab73_4"><p class="no_margin">DIC for a random-effects model lower than the DIC for a fixed-effects model.</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobch2appifig1"><div id="ch2.appi.fig1" class="figure"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Image%20ch2appif1&p=BOOKS&id=557360_ch2appif1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appif1.jpg" alt="Image ch2appif1" class="tileshop" title="Click on image to zoom" /></a></div></div></article><article data-type="table-wrap" id="figobch2appltab1"><div id="ch2.appl.tab1" class="table"><h3><span class="label">Table 37</span><span class="title">Resource use of interventions (63% attendance assumption highlighted)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appl.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appl.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Interventions</th><th id="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Num. sessions</th><th id="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Duration (minutes)</th><th id="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">N per session</th><th id="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Attendance in study (or assumption)</th><th id="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Selected data source</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Guided self-help</b>
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</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">4 to 8 weeks</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">2 to 3 hours</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;color:#9c0006;text-align:right;vertical-align:bottom;">1.9</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Assumption</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Group NDST</b>
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</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">12 to 16</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">45</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">8</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;color:#9c0006;text-align:right;vertical-align:bottom;">10.1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref65" rid="ch2.appo.ref65">Stice 2008</a>
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>IPT group</b>
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</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">12 to 16</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">90</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">5</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">6.8</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young 2016</a>
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Group mindfulness</b>
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</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">10 to 12</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">60 to 90</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">6</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">6.0</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Computer CBT</b>
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|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">8 Computer + 2 Face to face</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">45 to 60</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">2.0</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref71" rid="ch2.appo.ref71">Topooco 2018</a>
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
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<b>Group CBT</b>
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|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">12 to 16</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">90 - 120</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">8</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;color:#9c0006;text-align:right;vertical-align:bottom;">10.1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref11" rid="ch2.appo.ref11">Clarke 1999</a>
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Group CBT + parents</b>
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</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">12 to 16 + 8</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">90 - 120</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">8</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;color:#9c0006;text-align:right;vertical-align:bottom;">12.7</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref41" rid="ch2.appo.ref41">Lewinsohn 1990</a>
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Dance therapy</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">36</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">45</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">6</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;color:#9c0006;text-align:right;vertical-align:bottom;">22.8</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref35" rid="ch2.appo.ref35">Jeong 2005</a>
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Self-modelling</b>
|
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</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">6 to 8</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">45 to 60</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;color:#9c0006;text-align:right;vertical-align:bottom;">5.1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
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<b>Relaxation</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">12 to 16</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">30 to 60</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;color:#9c0006;text-align:right;vertical-align:bottom;">10.1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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<a class="bibr" href="#ch2.appo.ref36" rid="ch2.appo.ref36">Kahn 1990</a>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>BPI</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">8 child, 4 parents</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">45</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">8.0</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IMPACT</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>Family Therapy</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">10 to 12</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">50 to 60</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">9.71</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
|
|
<a class="bibr" href="#ch2.appo.ref17" rid="ch2.appo.ref17">Diamond 2010</a>
|
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</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>Non-directive supportive therapy (NDST)</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">10 to 20</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">45 to 60</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">11.2</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
|
|
<a class="bibr" href="#ch2.appo.ref7" rid="ch2.appo.ref7">Brent 1997</a>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>CBT (individual)</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">12 to 20 + up to 4 parents</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">55</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">9.7</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IMPACT</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>Interpersonal psychotherapy for adolescents (IPT-A)</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">12 to 16</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">35</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">11.5</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
|
|
<a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>STPP</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">up to 28 + up to 7 parents</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">50</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">13.9</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IMPACT</td></tr><tr><td headers="hd_h_ch2.appl.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>Behavioural Activation</b>
|
|
</td><td headers="hd_h_ch2.appl.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">10 to 20</td><td headers="hd_h_ch2.appl.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">50 to 60</td><td headers="hd_h_ch2.appl.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1</td><td headers="hd_h_ch2.appl.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">14.4</td><td headers="hd_h_ch2.appl.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
|
|
<a class="bibr" href="#ch2.appo.ref46" rid="ch2.appo.ref46">McCauley 2016</a>
|
|
</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appltab2"><div id="ch2.appl.tab2" class="table"><h3><span class="label">Table 38</span><span class="title">Cost estimates for Interventions</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appl.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appl.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interventions</th><th id="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Estimate low</th><th id="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Est high</th><th id="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Average of L + H</th><th id="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Best Estimate (Ave att)</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Guided self-help</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£87</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£257</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #63be7b;text-align:right;vertical-align:bottom;">£172</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #63be7b;text-align:right;vertical-align:bottom;">£119</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group NDST</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£98</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£456</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #7dc57c;text-align:right;vertical-align:bottom;">£277</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #76c37c;text-align:right;vertical-align:bottom;">£175</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">IPT group</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£157</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£365</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #79c47c;text-align:right;vertical-align:bottom;">£261</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #63be7b;text-align:right;vertical-align:bottom;">£120</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group mindfulness</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£145</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£342</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #74c37c;text-align:right;vertical-align:bottom;">£244</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #65be7b;text-align:right;vertical-align:bottom;">£126</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Computer CBT</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£131</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£228</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #64be7b;text-align:right;vertical-align:bottom;">£179</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #76c37c;text-align:right;vertical-align:bottom;">£176</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£196</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£456</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #89c97d;text-align:right;vertical-align:bottom;">£326</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #86c87d;text-align:right;vertical-align:bottom;">£223</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Group CBT + parents</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£261</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£570</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #9fcf7e;text-align:right;vertical-align:bottom;">£416</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #99cd7e;text-align:right;vertical-align:bottom;">£279</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Dance therapy</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£392</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£684</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #bed880;text-align:right;vertical-align:bottom;">£538</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #acd37f;text-align:right;vertical-align:bottom;">£335</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Self-modelling</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£392</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£912</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #dae081;text-align:right;vertical-align:bottom;">£652</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #d3de81;text-align:right;vertical-align:bottom;">£446</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relaxation</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£522</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£1,824</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #fecd7f;text-align:right;vertical-align:bottom;">£1,173</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #fec87e;text-align:right;vertical-align:bottom;">£765</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">BPI</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£522</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£1,368</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #ffdf82;text-align:right;vertical-align:bottom;">£945</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #fed480;text-align:right;vertical-align:bottom;">£701</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Family Therapy</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£653</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£1,368</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #ffda81;text-align:right;vertical-align:bottom;">£1,010</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #fdbe7c;text-align:right;vertical-align:bottom;">£853</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Non-directive supportive therapy (NDST)</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£653</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£2,280</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #fdb57a;text-align:right;vertical-align:bottom;">£1,466</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #fdbe7c;text-align:right;vertical-align:bottom;">£983</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">CBT (individual)</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£783</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£2,736</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #fb9d75;text-align:right;vertical-align:bottom;">£1,760</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #fdb77a;text-align:right;vertical-align:bottom;">£856</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Interpersonal psychotherapy for adolescents (IPT-A)</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£870</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£1,824</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #fdbf7c;text-align:right;vertical-align:bottom;">£1,347</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #fb9173;text-align:right;vertical-align:bottom;">£1,059</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">STPP</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£783</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£3,990</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #f8696b;text-align:right;vertical-align:bottom;">£2,387</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #f9746e;text-align:right;vertical-align:bottom;">£1,218</td></tr><tr><td headers="hd_h_ch2.appl.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Behavioural Activation</td><td headers="hd_h_ch2.appl.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£653</td><td headers="hd_h_ch2.appl.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:right;vertical-align:bottom;">£2,280</td><td headers="hd_h_ch2.appl.tab2_1_1_1_4" rowspan="1" colspan="1" style="background-color: #fdb57a;text-align:right;vertical-align:bottom;">£1,466</td><td headers="hd_h_ch2.appl.tab2_1_1_1_5" rowspan="1" colspan="1" style="background-color: #f96b6c;text-align:right;vertical-align:bottom;">£1,266</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appltab3"><div id="ch2.appl.tab3" class="table"><h3><span class="label">Table 39</span><span class="title">Cost estimates and NMA results (12–18 Severe)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appl.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appl.tab3_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appl.tab3_1_1_1_1" rowspan="2" colspan="2" headers="hd_h_ch2.appl.tab3_1_1_1_1" style="background-color: #28e4ff;text-align:left;vertical-align:middle;">Age 12–18 Severe</th><th id="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="3" colspan="1" headers="hd_h_ch2.appl.tab3_1_1_1_2" style="text-align:left;vertical-align:middle;">Depressive Symptoms Mean NMA Rank (17=bad)</th><th id="hd_h_ch2.appl.tab3_1_1_1_3" colspan="4" rowspan="1" style="text-align:left;vertical-align:middle;">Better than WL/control</th></tr><tr><th headers="hd_h_ch2.appl.tab3_1_1_1_3" id="hd_h_ch2.appl.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Depressive Symptoms Post Tx</th><th headers="hd_h_ch2.appl.tab3_1_1_1_3" id="hd_h_ch2.appl.tab3_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Functional Post Tx</th><th headers="hd_h_ch2.appl.tab3_1_1_1_3" id="hd_h_ch2.appl.tab3_1_1_2_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">QoL 6m</th><th headers="hd_h_ch2.appl.tab3_1_1_1_3" id="hd_h_ch2.appl.tab3_1_1_2_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Remission Post Tx</th></tr><tr><th headers="hd_h_ch2.appl.tab3_1_1_1_1" id="hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Interventions</th><th headers="hd_h_ch2.appl.tab3_1_1_1_1" id="hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Cost</th><th headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1" id="hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Post Tx</th><th headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2" id="hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Post Tx</th><th headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3" id="hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">6m</th><th headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4" id="hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Post Tx</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Guided self-help</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #63be7b;text-align:right;vertical-align:middle;">£119</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>9</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">IPT group</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #63be7b;text-align:right;vertical-align:middle;">£120</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>8</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Computer CBT</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #84c77c;text-align:right;vertical-align:middle;">£176</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>7</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Group CBT</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #84c77c;text-align:right;vertical-align:middle;">£223</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>10</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group CBT + parents</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #96cc7d;text-align:right;vertical-align:middle;">£279</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>10</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Relaxation</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fed781;text-align:right;vertical-align:middle;">£765</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>14</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">BPI</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fec77d;text-align:right;vertical-align:middle;">£701</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>11</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>Family Therapy</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fdb47a;text-align:right;vertical-align:middle;">£853</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>8</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Non-directive supportive therapy (NDST)</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fdb47a;text-align:right;vertical-align:middle;">£983</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>8</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>CBT (individual)</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fcae79;text-align:right;vertical-align:middle;">£856</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>7</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>Interpersonal psychotherapy for adolescents (IPT-A)</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fa8d72;text-align:right;vertical-align:middle;">£1,059</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>7</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>STPP</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #f9736d;text-align:right;vertical-align:middle;">£1,218</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>9</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Behavioural Activation</td><td headers="hd_h_ch2.appl.tab3_1_1_1_1 hd_h_ch2.appl.tab3_1_1_3_2" rowspan="1" colspan="1" style="background-color: #f96b6c;text-align:right;vertical-align:middle;">£1,266</td><td headers="hd_h_ch2.appl.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
|
|
<b>6</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_1 hd_h_ch2.appl.tab3_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_2 hd_h_ch2.appl.tab3_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7ce;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_3 hd_h_ch2.appl.tab3_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab3_1_1_1_3 hd_h_ch2.appl.tab3_1_1_2_4 hd_h_ch2.appl.tab3_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appltab4"><div id="ch2.appl.tab4" class="table"><h3><span class="label">Table 40</span><span class="title">Cost Estimates and NMA Results (12–18, Mild)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appl.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appl.tab4_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.appl.tab4_1_1_1_1" colspan="2" rowspan="1" style="background-color: #28e4ff;text-align:left;vertical-align:middle;">Population</th><th id="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="4" colspan="1" headers="hd_h_ch2.appl.tab4_1_1_1_2" style="text-align:left;vertical-align:middle;">Depressive symptoms mean NMA rank (14=bad)</th><th id="hd_h_ch2.appl.tab4_1_1_1_3" colspan="5" rowspan="1" style="text-align:left;vertical-align:middle;">Better than waiting list/control</th></tr><tr><th headers="hd_h_ch2.appl.tab4_1_1_1_1" id="hd_h_ch2.appl.tab4_1_1_2_1" colspan="2" rowspan="1" style="background-color: #28e4ff;text-align:left;vertical-align:bottom;">Age 12–18 Mild</th><th headers="hd_h_ch2.appl.tab4_1_1_1_3" id="hd_h_ch2.appl.tab4_1_1_2_2" colspan="3" rowspan="1" style="text-align:left;vertical-align:bottom;">Depressive symptoms</th><th headers="hd_h_ch2.appl.tab4_1_1_1_3" id="hd_h_ch2.appl.tab4_1_1_2_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Functional status</th><th headers="hd_h_ch2.appl.tab4_1_1_1_3" id="hd_h_ch2.appl.tab4_1_1_2_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Remission</th></tr><tr><th headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1" id="hd_h_ch2.appl.tab4_1_1_3_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Interventions</th><th headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1" id="hd_h_ch2.appl.tab4_1_1_3_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Cost</th><th headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2" id="hd_h_ch2.appl.tab4_1_1_3_3" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Post Tx</th><th headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2" id="hd_h_ch2.appl.tab4_1_1_3_4" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">6m</th><th headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2" id="hd_h_ch2.appl.tab4_1_1_3_5" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">18m</th><th headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3" id="hd_h_ch2.appl.tab4_1_1_3_6" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Post Tx</th><th headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4" id="hd_h_ch2.appl.tab4_1_1_3_7" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">Post Tx</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>Guided self-help</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #63be7b;text-align:right;vertical-align:middle;">£119</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>7</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Group NDST</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #74c37c;text-align:right;vertical-align:middle;">£175</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>10</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">IPT group</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #6dc07b;text-align:right;vertical-align:middle;">£120</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>4</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Group mindfulness</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #84c77c;text-align:right;vertical-align:middle;">£126</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;"></td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer CBT</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #84c77c;text-align:right;vertical-align:middle;">£176</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>4</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>Group CBT</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #84c77c;text-align:right;vertical-align:middle;">£223</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>7</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dance therapy</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #a8d17e;text-align:right;vertical-align:middle;">£335</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>7</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Self-modelling</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #cbdc81;text-align:right;vertical-align:middle;">£446</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Relaxation</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fed781;text-align:right;vertical-align:top;">£765</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:top;">
|
|
<b>6</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Family therapy</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fdb47a;text-align:right;vertical-align:middle;">£853</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>4</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Non-directive supportive therapy (NDST)</td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fdb47a;text-align:right;vertical-align:middle;">£983</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>11</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td></tr><tr><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">CBT (individual)<sup>*</sup></td><td headers="hd_h_ch2.appl.tab4_1_1_1_1 hd_h_ch2.appl.tab4_1_1_2_1 hd_h_ch2.appl.tab4_1_1_3_2" rowspan="1" colspan="1" style="background-color: #fcae79;text-align:right;vertical-align:middle;">£856</td><td headers="hd_h_ch2.appl.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:right;vertical-align:middle;">
|
|
<b>7</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_3" rowspan="1" colspan="1" style="background-color: #ffc7c9;text-align:left;vertical-align:middle;">
|
|
<b>✗</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_4" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_2 hd_h_ch2.appl.tab4_1_1_3_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
|
<b>NA</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_3 hd_h_ch2.appl.tab4_1_1_3_6" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td><td headers="hd_h_ch2.appl.tab4_1_1_1_3 hd_h_ch2.appl.tab4_1_1_2_4 hd_h_ch2.appl.tab4_1_1_3_7" rowspan="1" colspan="1" style="background-color: #c6efce;text-align:left;vertical-align:middle;">
|
|
<b>✓</b>
|
|
</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.appl.tab4_1"><p class="no_margin">Individual CBT cost for the mild population and other comparable costs may be over-estimated. See discussion at the start of this section for details.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobch2appmtab1"><div id="ch2.appm.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appm.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appm.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Author (year)</th><th id="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Title</th><th id="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reason for exclusion</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref87" rid="ch2.appo.ref87">Aalbers (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Music therapy for depression</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l213"><li id="ch2.lt901" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref88" rid="ch2.appo.ref88">Abbass (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy for children and adolescents: a meta-analysis of short-term psychodynamic models</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l214"><li id="ch2.lt902" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref89" rid="ch2.appo.ref89">Arnberg (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CBT for children with depressive symptoms: a meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l215"><li id="ch2.lt903" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref90" rid="ch2.appo.ref90">Bernecker (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For whom does interpersonal psychotherapy work? A systematic review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l216"><li id="ch2.lt904" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref91" rid="ch2.appo.ref91">Bevan (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychoeducational interventions in adolescent depression: A systematic review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l217"><li id="ch2.lt905" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref92" rid="ch2.appo.ref92">Chi (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effects of Mindfulness-Based Stress Reduction on Depression in Adolescents and Young Adults: A Systematic Review and Meta-Analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l218"><li id="ch2.lt906" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref93" rid="ch2.appo.ref93">Compton (2004)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive-behavioral psychotherapy for anxiety and depressive disorders in children and adolescents: An evidence-based medicine review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l219"><li id="ch2.lt907" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref94" rid="ch2.appo.ref94">Cook (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dialectical behavior therapy for nonsuicidal self-injury and depression among adolescents: Preliminary meta-analytic evidence</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l220"><li id="ch2.lt908" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref95" rid="ch2.appo.ref95">Crowe (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Efficacy of cognitive-behavioral therapy for childhood anxiety and depression</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l221"><li id="ch2.lt909" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref96" rid="ch2.appo.ref96">Devenish (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The treatment of suicidality in adolescents by psychosocial interventions for depression: A systematic literature review.</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l222"><li id="ch2.lt910" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref97" rid="ch2.appo.ref97">Dolle (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The treatment of depressive disorders in children and adolescents</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l223"><li id="ch2.lt911" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref98" rid="ch2.appo.ref98">Ebert (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Internet and computer-based cognitive behavioral therapy for anxiety and depression in youth: a meta-analysis of randomized controlled outcome trials.</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l224"><li id="ch2.lt912" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref99" rid="ch2.appo.ref99">Erford (2011)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Counselling outcomes from 1990 to 2008 for school-age youth with depression: A meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l225"><li id="ch2.lt913" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref100" rid="ch2.appo.ref100">Fleming (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Serious games for the treatment or prevention of depression: A systematic review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l226"><li id="ch2.lt914" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<a class="bibr" href="#ch2.appo.ref101" rid="ch2.appo.ref101">Forti-Buratti (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychological treatments for depression in pre-adolescent children (12 years and younger): systematic review and meta-analysis of randomised controlled trials.</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l227"><li id="ch2.lt915" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref102" rid="ch2.appo.ref102">Garber (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Treatment and Prevention of Depression and Anxiety in Youth: Test of Cross-Over Effects</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l228"><li id="ch2.lt916" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref103" rid="ch2.appo.ref103">Garcia-Escalera (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Efficacy of transdiagnostic cognitive-behavioral therapy for anxiety and depression in adults, children and adolescents: A meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l229"><li id="ch2.lt917" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<a class="bibr" href="#ch2.appo.ref104" rid="ch2.appo.ref104">Gertler (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-pharmacological interventions for depression in adults and children with traumatic brain injury</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l230"><li id="ch2.lt918" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref105" rid="ch2.appo.ref105">Goodyer (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Practitioner Review: Therapeutics of unipolar major depressions in adolescents</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l231"><li id="ch2.lt919" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref106" rid="ch2.appo.ref106">Grist (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mental Health Mobile Apps for Preadolescents and Adolescents: A Systematic Review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l232"><li id="ch2.lt920" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref107" rid="ch2.appo.ref107">Gualano (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The long-term effects of bibliotherapy in depression treatment: Systematic review of randomized clinical trials</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l233"><li id="ch2.lt921" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref108" rid="ch2.appo.ref108">Hollis (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Annual Research Review: Digital health interventions for children and young people with mental health problems - a systematic and meta-review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l234"><li id="ch2.lt922" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref109" rid="ch2.appo.ref109">Hunnicutt (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Preliminary evidence for the effectiveness of dialectical behavior therapy for adolescents</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l235"><li id="ch2.lt923" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref110" rid="ch2.appo.ref110">Kallapiran (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review: Effectiveness of mindfulness in improving mental health symptoms of children and adolescents: A meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l236"><li id="ch2.lt924" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref111" rid="ch2.appo.ref111">Keles (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A meta-analysis of group Cognitive Behavioral Therapy (CBT) interventions for adolescents with depression</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l237"><li id="ch2.lt925" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref112" rid="ch2.appo.ref112">Livheim (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The effectiveness of Acceptance and Commitment Therapy for adolescent mental health: Swedish and Australian pilot outcomes</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l238"><li id="ch2.lt926" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref113" rid="ch2.appo.ref113">Loades (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Treatment for paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) and comorbid depression: a systematic review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l239"><li id="ch2.lt927" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref114" rid="ch2.appo.ref114">Lockwood (2004)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparing the effectiveness of cognitive behaviour therapy using individual or group therapy in the treatment of depression</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l240"><li id="ch2.lt928" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref115" rid="ch2.appo.ref115">Loucas (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">E-therapies for mental health problems in children and young people: a systematic review and focus group investigation</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l241"><li id="ch2.lt929" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref116" rid="ch2.appo.ref116">Marcotte (1997)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Treating depression in adolescence: A review of the effectiveness of cognitive-behavioral treatments</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l242"><li id="ch2.lt930" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref117" rid="ch2.appo.ref117">Meekums (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dance movement therapy for depression</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l243"><li id="ch2.lt931" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref118" rid="ch2.appo.ref118">Midgley (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychodynamic psychotherapy for children and adolescents: an updated narrative review of the evidence base</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l244"><li id="ch2.lt932" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref119" rid="ch2.appo.ref119">Montgomery (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A systematic and empirical review of mindfulness interventions with adolescents: A potential fit for delinquency intervention</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l245"><li id="ch2.lt933" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref120" rid="ch2.appo.ref120">Morina (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychological interventions for post-traumatic stress disorder and depression in young survivors of mass violence in low- and middle-income countries: meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l246"><li id="ch2.lt934" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref121" rid="ch2.appo.ref121">Muller (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderators of the effects of indicated group and bibliotherapy cognitive behavioral depression prevention programs on adolescents’ depressive symptoms and depressive disorder onset</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l247"><li id="ch2.lt935" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref122" rid="ch2.appo.ref122">Mychailyszyn (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Working through the blues: A meta-analysis on interpersonal psychotherapy for depressed adolescents (IPT-A)</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l248"><li id="ch2.lt936" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref123" rid="ch2.appo.ref123">Pennant (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computerised therapies for anxiety and depression in children and young people: a systematic review and meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l249"><li id="ch2.lt937" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref124" rid="ch2.appo.ref124">Pu (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Efficacy and acceptability of interpersonal psychotherapy for depression in adolescents: A meta-analysis of randomized controlled trials</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l250"><li id="ch2.lt938" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref125" rid="ch2.appo.ref125">Rasing (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression and Anxiety Prevention Based on Cognitive Behavioral Therapy for At-Risk Adolescents: A Meta-Analytic Review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l251"><li id="ch2.lt939" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref126" rid="ch2.appo.ref126">Reyes-Portillo (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Web-based interventions for youth internalizing problems: a systematic review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l252"><li id="ch2.lt940" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref127" rid="ch2.appo.ref127">Rice (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Online and social networking interventions for the treatment of depression in young people: a systematic review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l253"><li id="ch2.lt941" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref128" rid="ch2.appo.ref128">Rodgers (2012)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The clinical effectiveness and cost-effectiveness of low-intensity psychological interventions for the secondary prevention of relapse after depression: A systematic review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l254"><li id="ch2.lt942" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref129" rid="ch2.appo.ref129">Rohde (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Major depression prevention effects for a cognitive-behavioral adolescent indicated prevention group intervention across four trials</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l255"><li id="ch2.lt943" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref130" rid="ch2.appo.ref130">Spinhoven (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The effects of cognitive-behavior therapy for depression on repetitive negative thinking: A meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l256"><li id="ch2.lt944" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref131" rid="ch2.appo.ref131">Stasiak (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Computer-Based and Online Therapy for Depression and Anxiety in Children and Adolescents</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l257"><li id="ch2.lt945" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref132" rid="ch2.appo.ref132">Stein (2006)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interventions for adolescent depression in primary care</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<ul id="ch2.l258"><li id="ch2.lt946" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref133" rid="ch2.appo.ref133">Straub (2014)</a>
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|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychotherapeutic treatment of children and adolescents with depression. Review of the literature on cognitive-behavioral and interpersonal group therapies (Provisional abstract)</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l259"><li id="ch2.lt947" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref134" rid="ch2.appo.ref134">Tindall (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Is behavioural activation effective in the treatment of depression in young people? A systematic review and meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l260"><li id="ch2.lt948" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref135" rid="ch2.appo.ref135">Valimaki (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Web-Based Interventions Supporting Adolescents and Young People With Depressive Symptoms: Systematic Review and Meta-Analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<ul id="ch2.l261"><li id="ch2.lt949" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref136" rid="ch2.appo.ref136">Verdeli (2006)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review of evidence-based psychotherapies for pediatric mood and anxiety disorders</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l262"><li id="ch2.lt950" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref137" rid="ch2.appo.ref137">Wade (2010)</a>
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|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Use of the internet to assist in the treatment of depression and anxiety: A systematic review</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<ul id="ch2.l263"><li id="ch2.lt951" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref138" rid="ch2.appo.ref138">Werner-Seidler (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">School-based depression and anxiety prevention programs for young people: A systematic review and meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l264"><li id="ch2.lt952" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref139" rid="ch2.appo.ref139">Wu (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A gap in the literature: Clinical role for smartphone applications for depression care among adolescents?</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<ul id="ch2.l265"><li id="ch2.lt953" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref140" rid="ch2.appo.ref140">Yang (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Efficacy and Acceptability of Cognitive Behavioral Therapy for Depression in Children: A Systematic Review and Meta-analysis.</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l266"><li id="ch2.lt954" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref141" rid="ch2.appo.ref141">Yatham (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression, anxiety, and post-traumatic stress disorder among youth in low and middle income countries: A review of prevalence and treatment interventions</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l267"><li id="ch2.lt955" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref142" rid="ch2.appo.ref142">Ye (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effectiveness of internet-based interventions for children, youth, and young adults with anxiety and/or depression: a systematic review and meta-analysis</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l268"><li id="ch2.lt956" class="half_rhythm"><div>More recent systematic reviews were checked that covered the same topic</div></li></ul></td></tr><tr><td headers="hd_h_ch2.appm.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref143" rid="ch2.appo.ref143">Yuan (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparative efficacy and acceptability of bibliotherapy for depression and anxiety disorders in children and adolescents: A meta-analysis of randomized clinical trials</td><td headers="hd_h_ch2.appm.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul id="ch2.l269"><li id="ch2.lt957" class="half_rhythm"><div>Systematic review used as a reference for individual RCTs</div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appmtab2"><div id="ch2.appm.tab2" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appm.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appm.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Author (year)</th><th id="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Title</th><th id="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reason for exclusion</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref144" rid="ch2.appo.ref144">Albornoz (2011)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The effects of group improvisational music therapy on depression in adolescents and adults with substance abuse: A randomized controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population does not match review protocol (majority of participants over the age of 18, and no subgroup analysis by age)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref255" rid="ch2.appo.ref255">Anderson (2014)</a>
|
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</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref146" rid="ch2.appo.ref146">Arnarson (2009)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Prevention of depression among Icelandic adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref147" rid="ch2.appo.ref147">Arora (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Components Analyses of a School-Based Cognitive Behavioral Treatment for Youth Depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparator does not match review protocol (paper does not report on comparator)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<a class="bibr" href="#ch2.appo.ref148" rid="ch2.appo.ref148">Barry (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Assessing the effectiveness of a cognitive behavioural group coaching intervention in reducing symptoms of depression among adolescent males in a school setting</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<a class="bibr" href="#ch2.appo.ref149" rid="ch2.appo.ref149">Bounoua (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotion regulation and spillover of interpersonal stressors to postsession insight among depressed and suicidal adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>Data not reported in an extractable format</p>
|
|
<p>
|
|
<i>Pair-review paper only reports baseline data. Follow-up data is only reported in the trial registration but standard deviations are too small. Therefore, it is uncertain whether standard deviation or standard error is reported</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<a class="bibr" href="#ch2.appo.ref150" rid="ch2.appo.ref150">Breland-Noble (2012)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a class="bibr" href="#ch2.appo.ref150" rid="ch2.appo.ref150">AAKOMA Project Adult Advisory Board (2012)</a> Community and treatment engagement for depressed African American youth: the AAKOMA FLOA pilot</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper does not report outcomes specified in review protocol</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref151" rid="ch2.appo.ref151">Brent (1999)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A clinical trial for adolescent depression: predictors of additional treatment in the acute and follow-up phases of the trial.</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Secondary publication of an included study that does not provide any additional relevant information</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<a class="bibr" href="#ch2.appo.ref152" rid="ch2.appo.ref152">Briere (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderators of two indicated cognitive-behavioral depression prevention approaches for adolescents in a school-based effectiveness trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper does not report outcomes specified in review protocol</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref153" rid="ch2.appo.ref153">Brown (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effective Treatment of Depressive Disorders in Medical Clinics for Adolescents and Young Adults living with HIV: A controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adult)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref154" rid="ch2.appo.ref154">Brunwasser (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Youth Cognitive-Behavioral Depression Prevention: Testing Theory in a Randomized Controlled Trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref155" rid="ch2.appo.ref155">Burckhardt (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A randomized controlled trial of strong minds: A school-based mental health program combining acceptance and commitment therapy and positive psychology.</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref156" rid="ch2.appo.ref156">Burton (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Pilot randomised controlled trial of Help4Mood, an embodied virtual agent-based system to support treatment of depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adult)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref157" rid="ch2.appo.ref157">Butler (1980)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The effect of two school-based intervention programs on depressive symptoms in preadolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Not a relevant study design</p>
|
|
<p><i>There was no randomisation</i>.</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref158" rid="ch2.appo.ref158">Chaplin (2006)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression prevention for early adolescent girls: A pilot study of all girls versus co-ed groups</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref160" rid="ch2.appo.ref160">Chen (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effectiveness RCT of a CBT intervention for youths who lost parents in the Sichuan, China, earthquake</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref159" rid="ch2.appo.ref159">Chen (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The effects of Chinese five-element music therapy on nursing students with depressed mood</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population does not match review protocol (mean age ≤18, and no subgroup analysis by age)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref161" rid="ch2.appo.ref161">Cheng (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Do parent mental illness and family living arrangement moderate the effects of the Aussie Optimism Program on depression and anxiety in children?</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref162" rid="ch2.appo.ref162">Chorpita (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Child STEPs in California: A cluster randomized effectiveness trial comparing modular treatment with community implemented treatment for youth with anxiety, depression, conduct problems, or traumatic stress</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes do not match review protocol</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref163" rid="ch2.appo.ref163">Chu (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Transdiagnostic group behavioral activation and exposure therapy for youth anxiety and depression: Initial randomized controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Intervention is aimed at treating both depression and anxiety</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref164" rid="ch2.appo.ref164">Clarke (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive-behavioral treatment of insomnia and depression in adolescents: A pilot randomized trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator in study does not match that specified in protocol</p>
|
|
<p>
|
|
<i>Both groups received CBT for depression. The comparator was for insomnia (sleep hygiene vs CBT for insomnia)</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref165" rid="ch2.appo.ref165">Compas (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Efficacy and moderators of a family group cognitive-behavioral preventive intervention for children of parents with depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref166" rid="ch2.appo.ref166">Curry (2011)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Recovery and recurrence following treatment for adolescent major depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper does not report outcomes specified in review protocol</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref167" rid="ch2.appo.ref167">Davidson (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Feasibility assessment of a brief, web-based behavioral activation intervention for adolescents with depressed mood</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref170" rid="ch2.appo.ref170">de Voogd (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Emotional working memory training as an online intervention for adolescent anxiety and depression: A randomised controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Emotional working memory training</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref170" rid="ch2.appo.ref170">de Voogd (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Online attentional bias modification training targeting anxiety and depression in unselected adolescents: Short- and long-term effects of a randomized controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Attentional bias modification</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref168" rid="ch2.appo.ref168">de Voogd (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Imagine the bright side of life: A randomized controlled trial of two types of interpretation bias modification procedure targeting adolescent anxiety and depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Online interpretation bias modification training</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref168" rid="ch2.appo.ref168">De Voogd (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Online visual search attentional bias modification for adolescents with heightened anxiety and depressive symptoms: A randomized controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Attentional bias modification</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref172" rid="ch2.appo.ref172">de Voogd (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A randomized controlled trial of multi-session online interpretation bias modification training: Short- and long-term effects on anxiety and depression in unselected adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Online interpretation bias modification training</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref173" rid="ch2.appo.ref173">Dickerson (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cost-effectiveness of cognitive behavioral therapy for depressed youth declining antidepressants</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Secondary publication of an included study that does not provide any additional relevant information</p>
|
|
<p><i>Reports cost-effectiveness of</i>
|
|
<a class="bibr" href="#ch2.appo.ref14" rid="ch2.appo.ref14">Clarke (2016)</a></p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref20" rid="ch2.appo.ref20">Duong (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mediators and Moderators of a School-Based Cognitive-Behavioral Depression Prevention Program</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Only reports moderators of treatment effect from previously reported trial</p>
|
|
<p>
|
|
<a class="bibr" href="#ch2.appo.ref45" rid="ch2.appo.ref45">McCarty 2013</a>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref175" rid="ch2.appo.ref175">Eckshtain (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Amelioration of Child Depression Through Behavioral Parent Training: A Preliminary Study</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparator does not match review protocol (paper does not report on comparator)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref176" rid="ch2.appo.ref176">Eckshtain (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Parental depressive symptoms as a predictor of outcome in the treatment of child depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparator does not match review protocol (paper does not report on comparator)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref177" rid="ch2.appo.ref177">Eisen (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Pilot study of implementation of an internet-based depression prevention intervention (CATCH-IT) for adolescents in 12 US primary care practices: Clinical and management/organizational behavioral perspectives</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator in study does not match that specified in protocol</p>
|
|
<p>
|
|
<i>Both groups received the same internet intervention (CATCH-IT: Competent Adulthood Transition with Cognitive-behavioural and Interpersonal Training). The comparators were motivational intervention and brief advice</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref178" rid="ch2.appo.ref178">Garber (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Prevention of Depression in At-Risk Adolescents: Moderators of Long-term Response</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Only reports moderators of treatment effect from previously reported trial</p>
|
|
<p>
|
|
<a class="bibr" href="#ch2.appo.ref45" rid="ch2.appo.ref45">McCarty 2013</a>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref179" rid="ch2.appo.ref179">Gillham (2012)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Evaluation of a Group Cognitive-Behavioral Depression Prevention Program for Young Adolescents: A Randomized Effectiveness Trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref180" rid="ch2.appo.ref180">Gunlicks-Stoessel (2010)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The impact of perceived interpersonal functioning on treatment for adolescent depression: IPT-A versus treatment as usual in school-based health clinics</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Only reports predictors of treatment effect in previously reported trial</p>
|
|
<p>
|
|
<a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref29" rid="ch2.appo.ref29">Gunlicks-Stoessel (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A Pilot SMART for Developing an Adaptive Treatment Strategy for Adolescent Depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Outcomes do not match review protocol</p>
|
|
<p>
|
|
<i>Only reports on patients’ clinical status with treatment using the Clinical Global Impressions scale</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref182" rid="ch2.appo.ref182">Gunlicks-Stoessel (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The role of attachment style in interpersonal psychotherapy for depressed adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data is not reported separately for intervention and comparator</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref183" rid="ch2.appo.ref183">Hassiotis (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Manualised Individual Cognitive Behavioural Therapy for mood disorders in people with mild to moderate intellectual disability: a feasibility randomised controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adult)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref184" rid="ch2.appo.ref184">Hendricks (2011)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Using Music Techniques to Treat Adolescent Depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Data not reported in an extractable format</p>
|
|
<p>
|
|
<i>Only reports means at baseline and follow-up for each arm</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref185" rid="ch2.appo.ref185">Horowitz (2007)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Prevention of depressive symptoms in adolescents: a randomized trial of cognitive-behavioral and interpersonal prevention programs</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref186" rid="ch2.appo.ref186">Jacobs (2010)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Treating depression and oppositional behavior in adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Outcomes do not match review protocol</p>
|
|
<p>
|
|
<i>Only reports on oppositional defiant disorder from previously reported trial (</i>
|
|
<a class="bibr" href="#ch2.appo.ref44" rid="ch2.appo.ref44">March 2004</a>
|
|
<i>, TADS study)</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref187" rid="ch2.appo.ref187">Jacobs (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Targeting Ruminative Thinking in Adolescents at Risk for Depressive Relapse: Rumination-Focused Cognitive Behavior Therapy in a Pilot Randomized Controlled Trial with Resting State fMRI</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Data not reported in an extractable format</p>
|
|
<p>
|
|
<i>Only reports data on mixed-effects regression model</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref188" rid="ch2.appo.ref188">Javanmiri (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The Study of Solution-Focused Group Counseling in Decreasing Depression among Teenage Girls</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not possible to allocate to mild or moderate to severe depression groups</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref189" rid="ch2.appo.ref189">Jones (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not All Masks Are Created Equal: Masking Success in Clinical Trials of Children and Adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports success of masking from previously reported trial (<a class="bibr" href="#ch2.appo.ref24" rid="ch2.appo.ref24">Fristad 2016</a>)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref190" rid="ch2.appo.ref190">Keerthy (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effect of Psychotherapy on Health Care Utilization in Children With Inflammatory Bowel Disease and Depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Data not reported in an extractable format</p>
|
|
<p>
|
|
<i>Only reports depressive severity at 1 year follow-up for both CBT and SNDT groups combined from a previously reported trial (</i>
|
|
<a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy 2014</a>
|
|
<i>)</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref191" rid="ch2.appo.ref191">Kindt (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The effect of a depression prevention program on negative cognitive style trajectories in early adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref192" rid="ch2.appo.ref192">Kolaitis (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-esteem and social adjustment in depressed youths: a randomized trial comparing psychodynamic psychotherapy and family therapy</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Only reports moderators of treatment effect from previously reported trial</p>
|
|
<p>
|
|
<a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref193" rid="ch2.appo.ref193">Kolko (2000)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cognitive and family therapies for adolescent depression: treatment specificity, mediation, and moderation</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper does not report outcomes specified in review protocol (state that depression symptoms were measure using Beck depression inventory, but these data are not reported)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kramer (2014)</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effectiveness of a Web-Based Solution-Focused Brief Chat Treatment for Depressed Adolescents and Young Adults: Randomized Controlled Trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population does not match review protocol (majority of participants over the age of 18, and no subgroup analysis by age)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref196" rid="ch2.appo.ref196">Kuosmanen (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A pilot evaluation of the SPARX-R gaming intervention for preventing depression and improving wellbeing among adolescents in alternative education</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref195" rid="ch2.appo.ref195">Kuosmanen (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The implementation of SPARX-R computerized mental health program in alternative education: Exploring the factors contributing to engagement and dropout</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref197" rid="ch2.appo.ref197">Kwok (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Positive psychology intervention to alleviate child depression and increase life satisfaction: A randomized clinical trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Positive psychology</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref198" rid="ch2.appo.ref198">Layne (2008)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effectiveness of a school-based group psychotherapy program for war-exposed adolescents: a randomized controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Trauma and grief component therapy for adolescents</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref199" rid="ch2.appo.ref199">Lewis (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The Impact on Family Functioning of Social Media Use by Depressed Adolescents: A Qualitative Analysis of the Family Options Study</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Qualitative study from a trial (<a class="bibr" href="#ch2.appo.ref52" rid="ch2.appo.ref52">Poole 2018</a>)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref200" rid="ch2.appo.ref200">Li (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systemic family therapy of comorbidity of anxiety and depression with epilepsy in adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator in study does not match that specified in protocol</p>
|
|
<p>
|
|
<i>Antiepileptic drugs</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref201" rid="ch2.appo.ref201">Luby (2012)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A novel early intervention for preschool depression: findings from a pilot randomized controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Participants were children under and over 5 years old with depression and data was not reported separately for the 5 years and older group</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref202" rid="ch2.appo.ref202">Luby (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Participants were children under and over 5 years old with depression and data was not reported separately for the 5 years and older group</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref203" rid="ch2.appo.ref203">Maina (2005)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomized controlled trial comparing brief dynamic and supportive therapy with waiting list condition in minor depressive disorders.</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adult)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref204" rid="ch2.appo.ref204">Manicavasagar (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Feasibility and effectiveness of a web-based positive psychology program for youth mental health: randomized controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref205" rid="ch2.appo.ref205">Matsuzaka (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Task shifting interpersonal counseling for depression: A pragmatic randomized controlled trial in primary care</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adult)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref206" rid="ch2.appo.ref206">McBain (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Improving outcomes for caregivers through treatment of young people affected by war: a randomized controlled trial in Sierra Leone</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Outcomes do not match review protocol</p>
|
|
<p>
|
|
<i>Only reports outcomes on caregivers</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref207" rid="ch2.appo.ref207">McGlinchey (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Innovations in Practice: The relationship between sleep disturbances, depression, and interpersonal functioning in treatment for adolescent depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Only reports predictors of treatment effect in previously reported trial</p>
|
|
<p>
|
|
<a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref208" rid="ch2.appo.ref208">Mead (2005)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The clinical effectiveness of guided self-help versus waiting-list control in the management of anxiety and depression: a randomized controlled trial.</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adult)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref209" rid="ch2.appo.ref209">Melvin (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Augmenting Cognitive Behavior Therapy for School Refusal with Fluoxetine: A Randomized Controlled Trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator does not match review protocol (paper does not report on comparator)</p>
|
|
<p>
|
|
<i>CBT was compared to 1) CBT plus placebo 2) CBT plus fluoxetine</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref210" rid="ch2.appo.ref210">Miller (2008)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interpersonal psychotherapy with pregnant adolescents: two pilot studies</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Not a relevant study design</p>
|
|
<p>
|
|
<i>Open trial</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref211" rid="ch2.appo.ref211">Moharreri (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Evaluation of the Effectiveness of the Friends for Life Program on Children’s Anxiety and Depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Intervention is aimed at treating both depression and anxiety</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref212" rid="ch2.appo.ref212">O’Leary-Barrett (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Two-year impact of personality-targeted, teacher-delivered interventions on youth internalizing and externalizing problems: a cluster-randomized trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref214" rid="ch2.appo.ref214">Park (2009)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The Efficacy of a Short-Term Group Program for Treating Depressive Disorder in Female Adolescents: a Comparison of the Cognitive-Behavioral and Psychoeducation Programs: a Preliminary Study</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper is not reported in English</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref214" rid="ch2.appo.ref214">Parker (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The effectiveness of simple psychological and physical activity interventions for high prevalence mental health problems in young people: A factorial randomised controlled trial.</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref215" rid="ch2.appo.ref215">Perry (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Preventing Depression in Final Year Secondary Students: School-Based Randomized Controlled Trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref216" rid="ch2.appo.ref216">Possel (2006)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparison of two school based depression prevention programs for adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper is not reported in English</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref217" rid="ch2.appo.ref217">Raes (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">School-based prevention and reduction of depression in adolescents: A cluster-randomized controlled trial of a mindfulness group program</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref218" rid="ch2.appo.ref218">Reed (1994)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Social skills training to reduce depression in adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper does not report outcomes specified in review protocol</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref219" rid="ch2.appo.ref219">Renaud (1998)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rapid response to psychosocial treatment for adolescent depression: a two-year follow-up</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper does not report outcomes separately for interventions and comparators specified in review protocol</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref220" rid="ch2.appo.ref220">Reyes-Portillo (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mediators of interpersonal psychotherapy for depressed adolescents on outcomes in Latinos: The role of peer and family interpersonal functioning</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Secondary publication of an included study that does not provide any additional relevant information</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref221" rid="ch2.appo.ref221">Richardson (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Collaborative care for adolescents with depression in primary care: A randomized clinical trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Collaborative care intervention with a choice of CBT, antidepressant medication, or both</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref222" rid="ch2.appo.ref222">Roberts (2003)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The prevention of depressive symptoms in rural school children: a randomized controlled trial.</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref223" rid="ch2.appo.ref223">Rohde (2012)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reduced substance use as a secondary benefit of an indicated cognitive-behavioral adolescent depression prevention program</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paper does not report outcomes specified in review protocol</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref226" rid="ch2.appo.ref226">Rohde (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sequenced versus coordinated treatment for adolescents with comorbid depressive and substance use disorders</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator in study does not match that specified in protocol</p>
|
|
<p>
|
|
<i>Family therapy focused on treating comorbidity (substance use disorder)</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref224" rid="ch2.appo.ref224">Rohde (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effectiveness trial of an indicated cognitive-behavioral group adolescent depression prevention program versus bibliotherapy and brochure control at 1- and 2-year follow-up</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref129" rid="ch2.appo.ref129">Rohde (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression Change Profiles in Adolescents Treated for Comorbid Depression/Substance Abuse and Profile Membership Predictors</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Outcomes do not match review protocol</p>
|
|
<p>
|
|
<i>Only reports trajectories of change in depression during treatment from a previously reported trial (</i>
|
|
<a class="bibr" href="#ch2.appo.ref226" rid="ch2.appo.ref226">Rohde 2014</a>
|
|
<i>)</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref227" rid="ch2.appo.ref227">Rooney (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reducing depression in 9–10 year old children in low SES schools: a longitudinal universal randomized controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref228" rid="ch2.appo.ref228">Saelid (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rational emotive behaviour therapy in high schools to educate in mental health and empower youth health. A randomized controlled study of a brief intervention</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref229" rid="ch2.appo.ref229">Sanford (2006)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A pilot study of adjunctive family psychoeducation in adolescent major depression: feasibility and treatment effect</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Data not reported in an extractable format</p>
|
|
<p>
|
|
<i>Standard deviations are only reported for baseline data but not for post-treatment or follow-up data. Therefore, we could not use any data in pairwise or NMA analyses</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref230" rid="ch2.appo.ref230">Saulsberry (2013)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomized clinical trial of a primary care Internet-based intervention to prevent adolescent depression: One-year outcomes</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator in study does not match that specified in protocol</p>
|
|
<p><i>One year outcomes of</i>
|
|
<a class="bibr" href="#ch2.appo.ref241" rid="ch2.appo.ref241">Van Voorhees 2009</a></p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref231" rid="ch2.appo.ref231">Schleider (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A single-session growth mindset intervention for adolescent anxiety and depression: 9-month outcomes of a randomized trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Mindset of personality</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref232" rid="ch2.appo.ref232">Shomaker (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A Randomized Controlled Trial to Prevent Depression and Ameliorate Insulin Resistance in Adolescent Girls at Risk for Type 2 Diabetes</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator in study does not match that specified in protocol</p>
|
|
<p>
|
|
<i>Health education is not in the list of comparators</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Prevention of insulin resistance in adolescents at risk for type 2 diabetes with depressive symptoms: 1-year follow-up of a randomized trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator in study does not match that specified in protocol</p>
|
|
<p>
|
|
<i>Health education is not in the list of comparators</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref234" rid="ch2.appo.ref234">Spence (2003)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Preventing adolescent depression: an evaluation of the problem solving for life program</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Problem solving for life programme which integrates 2 components: cognitive re-structuring and problem-solving skills training</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref235" rid="ch2.appo.ref235">Spence (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Improvements in interpersonal functioning following interpersonal psychotherapy (IPT) with adolescents and their association with change in depression</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Only reports predictors of treatment effect in previously reported trial</p>
|
|
<p>
|
|
<a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref236" rid="ch2.appo.ref236">Spirito (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Concurrent treatment for adolescent and parent depressed mood and suicidality: feasibility, acceptability, and preliminary findings</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Data not reported in an extractable format</p>
|
|
<p>
|
|
<i>Only reports data from the latent growth models</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref237" rid="ch2.appo.ref237">Stapersma (2018)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effectiveness of Disease-Specific Cognitive Behavioral Therapy on Anxiety, Depression, and Quality of Life in Youth With Inflammatory Bowel Disease: A Randomized Controlled Trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population does not match review protocol (mean age ≤18, and no subgroup analysis by age)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref238" rid="ch2.appo.ref238">Szigethy (2015)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effect of 2 psychotherapies on depression and disease activity in pediatric Crohn’s disease</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Data not reported in an extractable format</p>
|
|
<p><i>From a previously reported trial (</i><a class="bibr" href="#ch2.appo.ref68" rid="ch2.appo.ref68">Szigethy 2014</a><i>) See</i>
|
|
<a class="figpopup" href="/books/NBK557360/table/ch2.tab3/?report=objectonly" target="object" rid-figpopup="figch2tab3" rid-ob="figobch2tab3">table 3</a></p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref239" rid="ch2.appo.ref239">Thurman (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mitigating depression among orphaned and vulnerable adolescents: a randomized controlled trial of interpersonal psychotherapy for groups in South Africa</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref240" rid="ch2.appo.ref240">Trowell (2009)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Childhood depression: An outcome research project</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Secondary publication of an included study that does not provide any additional relevant information</p>
|
|
<p>
|
|
<i>Paper reports on comorbidity from a previously reported trial (</i>
|
|
<a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a>
|
|
<i>)</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref241" rid="ch2.appo.ref241">Van Voorhees (2009)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomized clinical trial of an Internet-based depression prevention program for adolescents (Project CATCH-IT) in primary care: 12-week outcomes</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Comparator in study does not match that specified in protocol</p>
|
|
<p>
|
|
<i>Both groups received the same internet intervention (CATCH-IT: Competent Adulthood Transition with Cognitive-behavioural and Interpersonal Training). The comparators were motivational intervention and brief advice</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref243" rid="ch2.appo.ref243">Weersing (2016)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Prevention of Depression in At-Risk Adolescents: Predictors and Moderators of Acute Effects</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Incorrect population (symptoms of depression not a criteria for inclusion in the study)</p>
|
|
<p>
|
|
<i>Reports on a trial excluded in the 2015 NICE update of this guideline (Garber 2009)</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref242" rid="ch2.appo.ref242">Weersing (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care: A Randomized Clinical Trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Intervention does not match interventions specified in review protocol</p>
|
|
<p>
|
|
<i>Intervention is aimed at treating both depression and anxiety</i>
|
|
</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref244" rid="ch2.appo.ref244">Whittaker (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MEMO: an mHealth intervention to prevent the onset of depression in adolescents: a double-blind, randomised, placebo-controlled trial</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref245" rid="ch2.appo.ref245">Wong (2014)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Preventing anxiety and depression in adolescents: A randomised controlled trial of two school based Internet-delivered cognitive behavioural therapy programmes</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref82" rid="ch2.appo.ref82">Young (2006)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Impact of comorbid anxiety in an effectiveness study of interpersonal psychotherapy for depressed adolescents</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>Secondary publication of an included study that does not provide any additional relevant information</p>
|
|
<p>
|
|
<i>Paper reports on depressive symptoms and level of function in participants with/without anxiety at baseline from a previously reported trial (</i>
|
|
<a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>
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<i>)</i>
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</p>
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</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref248" rid="ch2.appo.ref248">Young (2012)</a>
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</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interpersonal Psychotherapy-Adolescent Skills Training: Effects on School and Social Functioning</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Outcomes do not match review protocol</p>
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<p>
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<i>This paper reports on school and social functioning outcomes from a previously reported trial (</i>
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<a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a>
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<i>)</i>
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</p>
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</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref248" rid="ch2.appo.ref248">Young (2012)</a>
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</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interpersonal Psychotherapy-Adolescent skills training: Anxiety outcomes and impact of comorbidity</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Secondary publication of an included study that does not provide any additional relevant information</p>
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<p><i>Paper reports combined results from Young 2006a and</i>
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<a class="bibr" href="#ch2.appo.ref84" rid="ch2.appo.ref84">Young 2010</a></p>
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</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref85" rid="ch2.appo.ref85">Young (2016)</a>
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</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Predicting Therapeutic Effects of Psychodiagnostic Assessment Among Children and Adolescents Participating in Randomized Controlled Trials</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>Data not reported in an extractable format</p>
|
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<p>
|
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<i>Data on CDRS-R is only reported on a graph</i>
|
|
</p>
|
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</td></tr><tr><td headers="hd_h_ch2.appm.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<a class="bibr" href="#ch2.appo.ref246" rid="ch2.appo.ref246">Young (2017)</a>
|
|
</td><td headers="hd_h_ch2.appm.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Psychoeducational Psychotherapy and Omega-3 Supplementation Improve Co-Occurring Behavioral Problems in Youth with Depression: Results from a Pilot RCT</td><td headers="hd_h_ch2.appm.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<p>Outcomes do not match review protocol</p>
|
|
<p>
|
|
<i>Paper only reports on behaviour problems (</i>
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<a class="bibr" href="#ch2.appo.ref24" rid="ch2.appo.ref24">Fristad 2016</a>
|
|
<i>)</i>
|
|
</p>
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|
</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appmtab3"><div id="ch2.appm.tab3" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appm.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appm.tab3_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reference</th><th id="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reason for exclusion</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anon (2012) Computer therapy found effective treatment for depression in adolescents. Pediatric Annals 41: 217.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (Commentary)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Anon (2010) Randomised controlled trial of brief psychodynamic psychotherapy, cognitive behaviour therapy and treatment as usual in adolescents with moderate to severe depression attending routine child and adolescent mental health clinics (Project record). Health Technology Assessment Database</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only (no full text article)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ahmead M, Bower P (2008) The effectiveness of self-help technologies for emotional problems in adolescents: A systematic review. Child and Adolescent Psychiatry and Mental Health 2</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match protocol (population includes mix of adolescents and young adults, with no subgroup analysis by age)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Araya R, Fritsch R, Spears M et al. (2013) School intervention to improve mental health of students in Santiago, Chile: a randomized clinical trial. JAMA Pediatrics 167: 1004–10.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Participants were not selected because of symptoms of depression (universal intervention in schools)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Asarnow JR, Jaycox LH, Tang L et al. (2009) Long-term benefits of short-term quality improvement interventions for depressed youths in primary care. American Journal of Psychiatry 166: 1002–10.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention does not match interventions specified in review protocol</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Baas KD, Koeter MW, van Weert HC et al. (2010) Brief cognitive behavioral therapy compared to general practitioners care for depression in primary care: a randomized trial. Trials [Electronic Resource] 11: 96.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Barbe RP, Bridge J, Birmaher B et al. (2004) Suicidality and its relationship to treatment outcome in depressed adolescents. Suicide & Life-Threatening Behavior 34: 44–55.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports on predictive factors for treatment response from previously reported trial (Brent 1997)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Beardslee WR, Brent DA, Weersing VR et al. (2013) Prevention of depression in at-risk adolescents: longer-term effects. JAMA Psychiatry 70: 1161–70.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (current symptoms of depression not required for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Becker BJ, Gusrae R, Macnicol E (1963) A clinical study of a group psychotherapy program for adolescents. Psychiatric Quarterly 37: 685–703.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study type (case series)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Betancourt T (2012) A Feasibility Trial of the Youth Readiness Intervention: A Group Psychosocial Intervention for War-affected Youth in Sierra Leone. <a href="http://ClinicalTrials.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ClinicalTrials<wbr style="display:inline-block"></wbr>​.gov</a> [<a href="http://www.clinicaltrials.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">www<wbr style="display:inline-block"></wbr>​.clinicaltrials.gov</a>]</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Betancourt TS, Newnham EA, Brennan RT et al. (2012) Moderators of treatment effectiveness for war-affected youth with depression in northern Uganda. Journal of Adolescent Health 51: 544–50.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reports moderators of treatment effectiveness in previously reported trial (Bolton et al 2007). No additional effectiveness data reported.</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Birmaher B, Brent DA, Kolko D et al. (2000) Clinical outcome after short-term psychotherapy for adolescents with major depressive disorder. Archives of General Psychiatry 57: 29–36.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports moderators of treatment effect from previously reported trial (Brent 1997)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Boogar IR (2012) Effectiveness of the Teasdale Cognitive Therapy on depression reduction in guidance and high school students. [Farsi (Iranian)]. [References]. Psychological research 14: 25–40.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Article not obtainable (likely not in English)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Boylan K, Macpherson HA, Fristad MA (2013) Examination of disruptive behavior outcomes and moderation in a randomized psychotherapy trial for mood disorders. Journal of the American Academy of Child and Adolescent Psychiatry 52: 699–708.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population includes children with bipolar disorder</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Boylan MB (2006) Psychological mindedness as a predictor of treatment outcome with depressed adolescents. Dissertation Abstracts International: Section B: the Sciences and Engineering 67: 3479.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article: abstract only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Brent D (1997) A clinical trial comparing three psychotherapies for adolescent depression: differential efficacy and predictors of outcome. WPA Thematic Conf; 1997 Nov; Jerusalem : 9.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not full text article (conference report)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Brent DA, Kolko DJ, Birmaher B et al. (1998) Predictors of treatment efficacy in a clinical trial of three psychosocial treatments for adolescent depression. Journal of the American Academy of Child & Adolescent Psychiatry 37: 906–14.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports predictors of treatment response from previously reported trial (Brent 1997)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Brent DA, Roth CM, Holder DP et al. (1996) Psychosocial interventions for treating adolescent suicidal depression: A comparison of three psychosocial interventions. [References]. Hibbs, Euthymia D [Ed]; Jensen, Peter S [Ed] : 761–206.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol with preliminary results from individual participants only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Brook DW (2001) Group therapy with children and adolescents. International Journal of Group Psychotherapy 51: 437–41.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (narrative review)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Brown RA, Lewinsohn PM (1984) A psychoeducational approach to the treatment of depression: comparison of group, individual, and minimal contact procedures. Journal of Consulting & Clinical Psychology 52: 774–83.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adults)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bru L, Solholm R, Idsoe T (2013) Participants’ experiences of an early cognitive behavioral intervention for adolescents with symptoms of depression. Emotional and behavioural difficulties 18: 24–43.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population does not match review protocol (majority of participants over the age of 18, and no subgroup analysis by age)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Brunwasser SM, Gillham JE, Kim ES (2009) A meta-analytic review of the Penn Resiliency Program’s effect on depressive symptoms. Journal of Consulting & Clinical Psychology 77: 1042–54.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match review protocol (only includes subset of specified interventions) Use for cross checking</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bursuk LI (1998) The effects of a school-based cognitive-behavioral intervention program on the depression scores of sixth-grade students: A comparison outcome study. Dissertation Abstracts International Section A: Humanities and Social Sciences 59: 1065.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article (abstract only)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Calear AL, Christensen H (2010) Systematic review of school-based prevention and early intervention programs for depression. [Review] [80 refs]. Journal of Adolescence 33: 429–38.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match review protocol (only includes subset of specified interventions) Use for cross checking</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Calear AL, Christensen H, Mackinnon A et al. (2009) The Youth Mood Project: a cluster randomized controlled trial of an online cognitive behavioral program with adolescents. Journal of Consulting & Clinical Psychology 77: 1021–32.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not inclusion criteria for study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Chorpita BF, Weisz JR, Daleiden EL et al. (2013) Long-term outcomes for the Child STEPs randomized effectiveness trial: A comparison of modular and standard treatment designs with usual care. Journal of Consulting and Clinical Psychology 81: 999–1009.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not inclusion criteria for study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Christensen H, Pallister E, Smale S et al. (2010) Community-based prevention programs for anxiety and depression in youth: a systematic review. Journal of Primary Prevention 31: 139–70.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match review protocol (population not required to have symptoms of depression)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Clarizio HF (1985) Cognitive-behavioral treatment of childhood depression. Psychology in the schools 22: 308–22.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (narrative review)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Clarke G, Hops H, Lewinsohn PM et al. (1992) Cognitive-behavioral group treatment of adolescent depression: Prediction of outcome. Behavior Therapy 23: 341–54.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports on moderators of treatment efficacy in previously reported trial (Lewinsohn 1990)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Congleton AB (1996) The effect of a cognitive-behavioral group intervention on the locus of control, attributional style, and depressive symptoms of middle school students. Dissertation Abstracts International Section A: Humanities and Social Sciences 56: 3507.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article (abstract only)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cornelius JR, Douaihy A, Bukstein OG et al. (2011) Evaluation of cognitive behavioral therapy/motivational enhancement therapy (CBT/MET) in a treatment trial of comorbid MDD/AUD adolescents. Addictive Behaviors 36: 843–8.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not a randomised controlled trial</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cox GR, Fisher CA, De SS et al. (2012) Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents. Cochrane Database of Systematic Reviews 11: CD007504.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match protocol (population includes mix of adolescents and young adults)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cox GR, Callahan P, Churchill R et al. (2012) Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents. Cochrane Database of Systematic Reviews 11: CD008324.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match protocol (different psychological therapies not compared). NB forms the basis of the systematic review for review question 2</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Curry J, Rohde P, Simons A et al. (2006) Predictors and moderators of acute outcome in the Treatment for Adolescents with Depression Study (TADS). Journal of the American Academy of Child & Adolescent Psychiatry 45: 1427–39.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports moderators of treatment effect for previously reported study (TADS study, March et. al 2004)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Diamond G, Creed T, Gillham J et al. (2012) Sexual trauma history does not moderate treatment outcome in attachment-based family therapy (ABFT) for adolescents with suicidal ideation. Journal of Family Psychology 26: 595–605.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reports factors predicting outcomes in previously reported trial (Diamond et al. 2010)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dietz LJ, Marshal MP, Burton CM et al. (2014) Social problem solving among depressed adolescents is enhanced by structured psychotherapies. Journal of Consulting and Clinical Psychology 82: 202–11.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports predictors of treatment effects from results of previous trial (Brent et al. 1997)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Dolle K, Schulte-Korne G (2013) The treatment of depressive disorders in children and adolescents. Deutsches Arzteblatt International 110: 854–60.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Article not in English</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Domino ME, Burns BJ, Silva SG et al. (2008) Cost-effectiveness of treatments for adolescent depression: results from TADS. American Journal of Psychiatry 165: 588–96.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Secondary publication of an included study that does not provide any additional relevant information</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Donker T, Batterham PJ, Warmerdam L et al. (2013) Predictors and moderators of response to internet-delivered Interpersonal Psychotherapy and Cognitive Behavior Therapy for depression. Journal of Affective Disorders 151: 343–51.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adults)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eskin M, Ertekin K, Demir H (2008) Efficacy of a problem-solving therapy for depression and suicide potential in adolescents and young adults. Cognitive Therapy and Research 32: 227–45.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (study included young adults as well as adolescents and mean age was > 18)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Esposito-Smythers C, Spirito A, Kahler CW et al. (2011) Treatment of co-occurring substance abuse and suicidality among adolescents: a randomized trial. Journal of Consulting & Clinical Psychology 79: 728–39.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population not required to have symptoms of depression to participate</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ettelson RG (2003) The treatment of adolescent depression. Dissertation Abstracts International: Section B: the Sciences and Engineering 64: 1899.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article (abstract only)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fine S, Forth A, Gilbert M et al. (1991) Group therapy for adolescent depressive disorder: A comparison of social skills and therapeutic support. Journal of the American Academy of Child and Adolescent Psychiatry 30: 79–85.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study type (assignment to groups was not at random)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fischer G, Brunner R, Parzer P et al. (2013) Short-term psychotherapeutic treatment in adolescents engaging in non-suicidal self-injury: a randomized controlled trial. Trials [Electronic Resource] 14: 294.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fristad MA, Verducci JS, Walters K et al. (2009) Impact of multifamily psychoeducational psychotherapy in treating children aged 8 to 12 years with mood disorders. Archives of General Psychiatry 66: 1013–21.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population included children/young people with bipolar disorder</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Garber J, Clarke GN, Weersing VR et al. (2009) Prevention of depression in at-risk adolescents: a randomized controlled trial. JAMA 301: 2215–24.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (current symptoms of depression not required for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gau JM, Stice E, Rohde P et al. (2012) Negative life events and substance use moderate cognitive behavioral adolescent depression prevention intervention. Cognitive Behaviour Therapy 41: 241–50.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports the effect of moderators on treatment effects in previously reported trial (Stice et al 2008)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gordon MS, Tonge B, Melvin GA (2011) Outcome of adolescent depression: 6 months after treatment. Australian & New Zealand Journal of Psychiatry 45: 232–9.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports predictors of depression remission in participants from two previously-reported randomised controlled trials.</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Gunlicks-Stoessel M, Mufson L (2011) Early patterns of symptom change signal remission with interpersonal psychotherapy for depressed adolescents. Depression & Anxiety 28: 525–31.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports predictors of treatment effect in previously reported trial (Mufson et al 2004)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Guo X, Slesnick N, Feng X (2014) Reductions in depressive symptoms among substance-abusing runaway adolescents and their primary caretakers: a randomized clinical trial. Journal of Family Psychology 28: 98–105.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Symptoms of depression not inclusion criteria for study</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Harrington R, Campbell F, Shoebridge P et al. (1998) Meta-analysis of CBT for depression in adolescents. Journal of the American Academy of Child & Adolescent Psychiatry 37: 1005–7.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (letter/comment)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Harrington R, Whittaker J, Shoebridge P et al. (1998) Systematic review of efficacy of cognitive behaviour therapies in childhood and adolescent depressive disorder. BMJ 316: 1559–63.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (letter/comment)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Harrington R, Whittaker J, Shoebridge P et al. (1998) Systematic review of efficacy of cognitive behaviour therapies in childhood and adolescent depressive disorder. BMJ 316: 1559–63.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match the review protocol (only includes a subset of the specified interventions). Use for cross checking</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hazell P (2011) Depression in children and adolescents. Clinical Evidence 2011, 2011.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (narrative review)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hetrick SE, Cox GR, Merry SN (2011) Treatment-resistant depression in adolescents: is the addition of cognitive behavioral therapy of benefit? Psychology Research & Behavior Management 4: 97–112.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match the review protocol (only includes a subset of the specified interventions). Use for cross checking</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hickman KA (1995) Effects of social skills training on depressed children attending a behavioural day treatment program. Dissertation abstracts international 56: 1699.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article available, abstract only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hoek W, Schuurmans J, Koot HM et al. (2012) Effects of Internet-based guided self-help problem-solving therapy for adolescents with depression and anxiety: a randomized controlled trial. PLoS ONE [Electronic Resource] 7: e43485.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression were not required for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hoek W, Schuurmans J, Koot HM et al. (2009) Prevention of depression and anxiety in adolescents: a randomized controlled trial testing the efficacy and mechanisms of Internet-based self-help problem-solving therapy. Trials [Electronic Resource] 10: 93.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Horn H, Geiser-Elze A, Reck C et al. (2005) [Efficacy of psychodynamic short-term psychotherapy for children and adolescents with depression]. Praxis der Kinderpsychologie und Kinderpsychiatrie 54: 578–97.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclude: Article not in English</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hyun MS, Nam KA, Kim MA (2010) Randomized controlled trial of a cognitive-behavioral therapy for at-risk Korean male adolescents. Archives of Psychiatric Nursing 24: 202–11.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Symptoms of depression was not inclusion criteria for population</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ingram D, Moreno M (2012) A computerized self-help intervention is as effective as face-to-face counselling for adolescents seeking help for depression. Journal of Pediatrics 161: 967–8.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (commentary on Merry et al 2012)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Jaycox LH, Reivich KJ, Gillham J et al. (1994) Prevention of depressive symptoms in school children. Behaviour Research & Therapy 32: 801–16.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Symptoms of depression was not inclusion criteria for population</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kaufman NK, Rohde P, Seeley JR et al. (2005) Potential mediators of cognitive-behavioral therapy for adolescents with comorbid major depression and conduct disorder. Journal of Consulting & Clinical Psychology 73: 38–46.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparator does not match review protocol (life skills training)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kennard BD, Silva SG, Mayes TL et al. (2009) Assessment of safety and long-term outcomes of initial treatment with placebo in TADS. American Journal of Psychiatry 166: 337–44.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Invention and and comparator do not match review protcol (part of the TADS study - compares all active treatment groups combined to placebo group)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Klein JB, Jacobs RH, Reinecke MA (2007) Cognitive-behavioral therapy for adolescent depression: a meta-analytic investigation of changes in effect-size estimates. Journal of the American Academy of Child & Adolescent Psychiatry 46: 1403–13.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match review protocol (only includes subset of specified interventions) Use for cross checking</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kolaitis G, Pomini V, Tomaras V et al. (2011) Psychodynamic and family psychotherapy for young people with major depression: Preliminary findings on their psychosocial adjustment. Childhood depression: A place for psychotherapy: 221–5.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Secondary publication of an included study that does not provide any additional relevant information</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kovacs M (2001) Psychotherapy for young dysthymic children. <a href="http://crisp.cit.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://crisp<wbr style="display:inline-block"></wbr>​.cit.nih.gov/</a></td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Unobtainable by information services (incomplete database record, does not appear to be journal publication)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kowalenko N, Rapee RM, Simmons J et al. (2005) Short-term effectiveness of a school-based early intervention program for adolescent depression. Clinical Child Psychology and Psychiatry 10: 493–507.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study type (allocated to groups was not randomised)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kratochvil C, Emslie G, Silva S et al. (2006) Acute time to response in the Treatment for Adolescents with Depression Study (TADS). Journal of the American Academy of Child & Adolescent Psychiatry 45: 1412–8.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (narrative review)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kratochvil CJ, May DE, Silva SG et al. (2009) Treatment response in depressed adolescents with and without co-morbid attention-deficit/hyperactivity disorder in the Treatment for Adolescents with Depression Study. Journal of Child & Adolescent Psychopharmacology 19: 519–27.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports moderators of treatment effect in previously reported trial (March et al. 2004)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kroll L, Harrington R, Jayson D et al. (1996) Pilot study of continuation cognitive-behavioral therapy for major depression in adolescent psychiatric patients. Journal of the American Academy of Child & Adolescent Psychiatry 35: 1156–61.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study type (not a randomised controlled trial)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lee J (2007) Mindfulness-based cognitive therapy for children: Feasibility, acceptability, and effectiveness of a controlled clinical trial. Dissertation Abstracts International: Section B: the Sciences and Engineering 67: 6064.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article - abstract only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lewis CC, Simons AD, Nguyen LJ et al. (2010) Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS). Journal of the American Academy of Child & Adolescent Psychiatry 49: 132–40.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports moderators of treatment effect in previously reported trial (March et al. 2004)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lewis CC, Simons AD, Silva SG et al. (2009) The role of readiness to change in response to treatment of adolescent depression. Journal of Consulting & Clinical Psychology 77: 422–8.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports moderators of treatment effect in previously reported trial (March et al. 2004)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Liehr P, Diaz N (2010) A pilot study examining the effect of mindfulness on depression and anxiety for minority children. Archives of Psychiatric Nursing 24: 69–71.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Symptoms of depression was not criteria for inclusion in population</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lillevoll KR, Vangberg HC, Griffiths KM et al. (2014) Uptake and adherence of a self-directed internet-based mental health intervention with tailored e-mail reminders in senior high schools in Norway. BMC Psychiatry 14: 14.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not required for inclusion in study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Listug-Lunde LB (2005) A cognitive-behavioral treatment for depression in Native American middle-school students. Dissertation Abstracts International: Section B: the Sciences and Engineering 66: 1176.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article (abstract only)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lynch FL, Hornbrook M, Clarke GN et al. (2005) Cost-effectiveness of an intervention to prevent depression in at-risk teens. Archives of General Psychiatry 62: 1241–8.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports costeffectiveness analysis of previously reported trial (Clarke et al. 2001)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Maag JW, Swearer SM, Toland MD (2009) Cognitive-behavioral interventions for depression in children and adolescents: meta-analysis, promising programs, and implications for school personnel (Structured abstract). Database of Abstracts of Reviews of Effects Chapter 9: 235–65.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not meet quality standards outlined in NICE methods handbook (only small subset of relevant databases searched)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mahoney JR, Kennard BD, Mayes TL (2011) Cognitive behavioral treatment of depression in youth. Pediatric Annals 40: 307–13.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (narrative review/instructional article)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Manassis K, Wilansky-Traynor P, Farzan N et al. (2010) The feelings club: randomized controlled evaluation of school-based CBT for anxious or depressive symptoms. Depression & Anxiety 27: 945–52.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Symptoms of depression was not criteria for inclusion in population</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">March J, Silva S, Petrycki S et al. (2005) The Treatment for Adolescents with Depression Study (TADS): Demographic and clinical characteristics. Journal of the American Academy of Child and Adolescent Psychiatry 44: 28–40.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study protocol/demographic analysis only, no results presented</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">March JS, Silva S, Petrycki S et al. (2007) The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes.[Erratum appears in Arch Gen Psychiatry. 2008 Jan;65(1):101]. Archives of General Psychiatry 64: 1132–43.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No valid comparator (part of TADS study reporting outcomes after 12 weeks, after which placebo group did not continue)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Merry SN (2009) Cognitive behavioral therapy prevents depression in at-risk adolescents. Journal of Pediatrics 155: 758.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (Narrative review/comment)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Midgley N, Kennedy E (2011) Psychodynamic psychotherapy for children and adolescents: A critical review of the evidence base. Journal of Child Psychotherapy 37: 232–60.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match review protocol (only includes subset of specified interventions) Use for cross checking</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moldenhauer Z (2004) Adolescent depression: A primary care pilot intervention study. Dissertation Abstracts International: Section B: the Sciences and Engineering 65: 656.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article (abstract only)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mufson LH, Collins K (2006) Group interpersonal psychotherapy for depressed adolescents (IPT-AG) in school-based clinics [<a href="https://clinicaltrials.gov/show/NCT00270244" title="Study NCT00270244" ref="pagearea=body&targetsite=external&targetcat=link&targettype=clinical-trial">NCT00270244</a>]. <a href="http://ClinicalTrials.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ClinicalTrials<wbr style="display:inline-block"></wbr>​.gov</a> [<a href="http://www.clinicaltrials.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">www<wbr style="display:inline-block"></wbr>​.clinicaltrials.gov</a>]</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nauta MH, Festen H, Reichart CG et al. (2012) Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients. BMC Psychiatry 12: 31.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nobel R, Manassis K, Wilansky-Traynor P (2012) The role of perfectionism in relation to an intervention to reduce anxious and depressive symptoms in children. Journal of Rational-Emotive & Cognitive-Behavior Therapy 30: 77–90.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">O’Kearney R, Kang K, Christensen H et al. (2009) A controlled trial of a school-based Internet program for reducing depressive symptoms in adolescent girls. Depression & Anxiety 26: 65–72.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">O’Kearney R, Gibson M, Christensen H et al. (2006) Effects of a cognitive-behavioural internet program on depression, vulnerability to depression and stigma in adolescent males: a school-based controlled trial. Cognitive Behaviour Therapy 35: 43–54.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">O’Kearney R, Kang K, Gibson M et al. (2007) A CBT internet program for depression in adolescents (MoodGYM): Effects on depressive symptoms, attributional style, self-esteem and beliefs about depression. 197–204.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (narrative review/summary of previous studies)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Parraga J (1984) Psychological treatments in childhood depression: cognitive therapy, skinner therapy and mixed therapy. A comparative study. Revista De Neuropsiquiatría Infantil 2: 107–35.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Commentary on previously reported trial (TADS)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Platania-Solazzo A, Field TM, Blank J et al. (1992) Relaxation therapy reduces anxiety in child and adolescent psychiatric patients. Acta Paedopsychiatrica: 115–20.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Punamaki RL, Paavonen J, Toikka S et al. (2013) Effectiveness of preventive family intervention in improving cognitive attributions among children of depressed parents: a randomized study. Journal of Family Psychology 27: 683–90.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression no required for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reinecke MA, Ryan NE, DuBois DL (1998) Cognitive-behavioral therapy of depression and depressive symptoms during adolescence: a review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry 37: 26–34</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match review protocol (only includes subset of specified interventions) Use for cross checking</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Richardson T, Stallard P, Velleman S (2010) Computerised cognitive behavioural therapy for the prevention and treatment of depression and anxiety in children and adolescents: a systematic review. [Review]. Clinical Child & Family Psychology Review 13: 275–90.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that does not match the review protocol (includes studies on prevention, as well as treatment of depression)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rohde P, Silva SG, Tonev ST et al. (2008) Achievement and maintenance of sustained response during the Treatment for Adolescents With Depression Study continuation and maintenance therapy. Archives of General Psychiatry 65: 447–55.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No valid comparator (part of TADS study reporting outcomes after 12 weeks, after which placebo group did not continue)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rohde P, Clarke GN, Mace DE et al. (2004) An efficacy/effectiveness study of cognitive-behavioral treatment for adolescents with comorbid major depression and conduct disorder. Journal of the American Academy of Child & Adolescent Psychiatry 43: 660–8.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparator does not match review protocol (life skills training)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rohde P, Seeley JR, Clarke GN et al. (2006) Predicting time to recovery among depressed adolescents treated in two psychosocial group interventions. Journal of Consulting and Clinical Psychology 74: 80–8.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports moderators of treatment effect in previously reported trial (Rohde 2004)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rohde P, Stice E, Gau JM (2012) Effects of three depression prevention interventions on risk for depressive disorder onset in the context of depression risk factors. Prevention Science 13: 584–93.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports predictors of treatment effect in previously reported trial (Stice et al. 2008, 2010)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rohde P, Clarke GN, Lewinsohn PM et al. (2001) Impact of comorbidity on a cognitive-behavioral group treatment for adolescent depression. [References]. Journal of the American Academy of Child & Adolescent Psychiatry 40: 795–802.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only reports moderators of treatment effect in previously reported trial (Lewisohn 1990, Clarke 1999)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rohde P, Stice E, Shaw H et al. (2014) Indicated cognitive behavioral group depression prevention compared to bibliotherapy and brochure control: Acute effects of an effectiveness trial with adolescents. [References]. Journal of Consulting and Clinical Psychology 82: 65–74.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression were not an inclusion criteria for the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rose K, Hawes DJ, Hunt CJ (2014) Randomized controlled trial of a friendship skills intervention on adolescent depressive symptoms. Journal of Consulting and Clinical Psychology 82: 510–20.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression were not an inclusion criteria for the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rossello J, Bernal G, Rivera-Medina C (2008) Individual and group CBT and IPT for Puerto Rican adolescents with depressive symptoms. Cultural Diversity & Ethnic Minority Psychology 14: 234–45.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Compared individual and group cognitive behavioural therapy (CBT) with individual and group interpersonal psychotherapy (IPT) but results not reported for each group separately (only presented for individual vs group or CBT vs IPT)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rossouw TI, Fonagy P (2012) Mentalization-based treatment for self-harm in adolescents: a randomized controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry 51: 1304–13.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Salsman NL, Arthur R (2011) Adapting dialectical behavior therapy to help suicidal adolescents. Current Psychiatry 10: 18–33.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (narrative review)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schaik AM (2008) No added value of cognitive behavior therapy in adolescents with depression. Nederlands tijdschrift voor geneeskunde 152: 56.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Article not in English</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schramm E, Zobel I, Dykierek P et al. (2011) Cognitive behavioral analysis system of psychotherapy versus interpersonal psychotherapy for early-onset chronic depression: a randomized pilot study. Journal of Affective Disorders 129: 109–16.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adult)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Scott CV (1999) Evaluation of cognitive-behavioral group therapy in treating depressive symptoms in prepubertal children: A pilot study. Dissertation Abstracts International: Section B: the Sciences and Engineering 60: 2960.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article (abstract only)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Semple RJ (2006) Mindfulness-Based Cognitive Therapy for children: A randomized group psychotherapy trial developed to enhance attention and reduce anxiety. Dissertation Abstracts International: Section B: the Sciences and Engineering 66: 5105.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No full text article (abstract only)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sethi S, Campbell AJ, Ellis LA (2010) The use of computerized self-help packages to treat adolescent depression and anxiety. Journal of Technology in Human Services 28: 144–60.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (aged up to 25 years)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sethi S (2013) Treating youth depression and anxiety: A randomised controlled trial examining the efficacy of computerised versus face-to-face cognitive behaviour therapy. Australian Psychologist 48: 249–57.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (18–25 year olds)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sheffield JK, Spence SH, Rapee RM et al. (2006) Evaluation of universal, indicated, and combined cognitive-behavioral approaches to the prevention of depression among adolescents. Journal of Consulting & Clinical Psychology 74: 66–79.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Spinhoven P, Slee N, Garnefski N et al. (2009) Childhood sexual abuse differentially predicts outcome of cognitive-behavioral therapy for deliberate self-harm. Journal of Nervous & Mental Disease 197: 455–7.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (adult)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Stallard P (2010) A single blind randomised controlled trial to determine the effectiveness of group Cognitive Behaviour Therapy (CBT) in the prevention of depression in high risk adolescents [ISRCTN19083628]. Health Technology Research Projects <a href="http://www.hta.ac.uk/1667" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">www<wbr style="display:inline-block"></wbr>​.hta.ac.uk/1667</a> (accessed 7 August 2013)</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Stallard P, Richardson T, Velleman S et al. (2011) Computerized CBT (Think, Feel, Do) for depression and anxiety in children and adolescents: outcomes and feedback from a pilot randomized controlled trial. Behavioural & Cognitive Psychotherapy 39: 273–84.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Steinberg EB, Sayger TV, Szykula SA (1997) The effects of strategic and behavioral family therapies on child behavior and depression. Contemporary Family Therapy: An International Journal 19: 537–51.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Stice E, Burton E, Bearman SK et al. (2007) Randomized trial of a brief depression prevention program: an elusive search for a psychosocial placebo control condition. Behaviour Research & Therapy 45: 863–76.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (included participants up to the age of 22)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Stikkelbroek Y, Bodden DH, Dekovic M et al. (2013) Effectiveness and cost effectiveness of cognitive behavioral therapy (CBT) in clinically depressed adolescents: individual CBT versus treatment as usual (TAU). BMC Psychiatry 13: 314.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Trial protocol only</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tang TC, Jou SH, Ko CH et al. (2009) Randomized study of school-based intensive interpersonal psychotherapy for depressed adolescents with suicidal risk and parasuicide behaviors. Psychiatry & Clinical Neurosciences 63: 463–70.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (participants were not required to have symptoms of depression)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Treatment for Adolescents With Depression Study (TADS) Team, March J, Silva S et al. (2009) The Treatment for Adolescents With Depression Study (TADS): outcomes over 1 year of naturalistic follow-up. American Journal of Psychiatry 166: 1141–9.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparator does not match review protocol (part of TADS study reporting 1 year follow up, but placebo control group only included up to 12 weeks)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">van der Zanden R, Kramer J, Gerrits R et al. (2012) Effectiveness of an online group course for depression in adolescents and young adults: a randomized trial. Journal of Medical Internet Research 14: e86.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (included participants up to the age of 25)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Vitiello B (2008) Treatment for Adolescents with Depression Study (TADS). BMJ 337: 890.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (letter/comment)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Vostanis P, Feehan C, Grattan E (1998) Two-year outcome of children treated for depression. European Child & Adolescent Psychiatry 7: 12–8.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study type (not a randomised controlled trial as subjects were allocated to interventions alternately)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Weisz JR, McCarty CA, Valeri SM (2006) Effects of psychotherapy for depression in children and adolescents: a meta-analysis. Psychological Bulletin 132: 132–49.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review with insufficient details to judge whether meets quality criteria specified in the NICE clinical guidelines manual. Use for cross checking.</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Weisz JR, Weiss B, Han SS et al. (1995) Effects of psychotherapy with children and adolescents revisited: a meta-analysis of treatment outcome studies. Psychological Bulletin 117: 450–68.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review that did not meet criteria specified in review protocol (population was children with all psychological problems, not specifically depression)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Weitkamp K, Daniels JK, Hofmann H et al. (2014) Psychoanalytic psychotherapy for children and adolescents with severe depressive psychopathology: preliminary results of an effectiveness trial. Psychotherapy: Theory, Research, Practice, Training 51: 138–47.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect study type (non-randomised controlled study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Wood A, Trainor G, Rothwell J et al. (2001) Randomized trial of group therapy for repeated deliberate self-harm in adolescents. Journal of the American Academy of Child & Adolescent Psychiatry 40: 1246–53.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Incorrect population (symptoms of depression not a criteria for inclusion in the study)</td></tr><tr><td headers="hd_h_ch2.appm.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Zuckerbrot RA (2007) Combined fluoxetine plus cognitive behavioural therapy is more effective than monotherapy or placebo for adolescents with depression. Evidence-Based Mental Health 10: 84.</td><td headers="hd_h_ch2.appm.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not primary research (summary of previously reported study)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appmtab4"><div id="ch2.appm.tab4" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appm.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appm.tab4_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Short Title</th><th id="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Title</th><th id="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reason for exclusion</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref145" rid="ch2.appo.ref145">Anderson (2014)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention delivered to a general population of scholar age children with no formal diagnosis of depression. The results of the analysis are not presented separately for high risk individuals.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref89" rid="ch2.appo.ref89">Arnberg (2014)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Internet-delivered psychological treatments for mood and anxiety disorders: a systematic review of their efficacy, safety, and cost-effectiveness</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Not an economic evaluation.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref257" rid="ch2.appo.ref257">Bee (2014)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The clinical effectiveness, cost-effectiveness and acceptability of community-based interventions aimed at improving or maintaining quality of life in children of parents with serious mental illness: A systematic review</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interventions destined to children of parents with psychiatric disease, not necessarily depressed children.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref258" rid="ch2.appo.ref258">Brettschneider (2015)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cost-utility analyses of cognitive-behavioural therapy of depression: a systematic review</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Systematic review of economics evaluations. Checked for relevant references.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref260" rid="ch2.appo.ref260">Lee (2017)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The population cost-effectiveness of delivering universal and indicated school-based interventions to prevent the onset of major depression among youth in Australia</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interventions in the context of prevention not treatment. Results expressed in $/DALY.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref261" rid="ch2.appo.ref261">Macdonald (2016)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The effectiveness, acceptability and cost-effectiveness of psychosocial interventions for maltreated children and adolescents: an evidence synthesis</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cost-effectiveness analysis of CBT for children with depression and posttraumatic stress disorder (PTSD) who were victims of sexual abuse. Results reported for PTSD and anxiety.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meuldijk (2015)</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Economic Evaluation of Concise Cognitive Behavioural Therapy and/or Pharmacotherapy for Depressive and Anxiety Disorders</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Interventions destined to children who were maltreated, not necessarily depressed children.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref262" rid="ch2.appo.ref262">Philipsson (2013)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cost-utility analysis of a dance intervention for adolescent girls with internalizing problems</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention targeted at adolescent girls with internalising problems. Not specific to depression in children and adolescents.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref128" rid="ch2.appo.ref128">Rodgers (2012)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The clinical effectiveness and cost-effectiveness of low-intensity psychological interventions for the secondary prevention of relapse after depression: A systematic review</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention in adults.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref264" rid="ch2.appo.ref264">Stafford (2018)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effectiveness and cost-effectiveness of humanistic counselling in schools for young people with emotional distress (ETHOS): study protocol for a randomised controlled trial</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study protocol.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref62" rid="ch2.appo.ref62">Stallard (2013)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A cluster randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of classroom-based cognitive-behavioural therapy (CBT) in reducing symptoms of depression in high-risk adolescents</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Same as <a class="bibr" href="#ch2.appo.ref145" rid="ch2.appo.ref145">Anderson 2014</a>.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref266" rid="ch2.appo.ref266">Stikkelbroek (2013)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Effectiveness and cost effectiveness of cognitive behavioral therapy (CBT) in clinically depressed adolescents: individual CBT versus treatment as usual (TAU)</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study protocol.</td></tr><tr><td headers="hd_h_ch2.appm.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a class="bibr" href="#ch2.appo.ref267" rid="ch2.appo.ref267">Wellander (2016)</a>
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</td><td headers="hd_h_ch2.appm.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Does Prevention Pay? Costs and Potential Cost-savings of School Interventions Targeting Children with Mental Health Problems</td><td headers="hd_h_ch2.appm.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cost-offset analysis.</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appntab1"><div id="ch2.appn.tab1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appn.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appn.tab1_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.appn.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO</th><td headers="hd_b_ch2.appn.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Population:</b>
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<ul id="ch2.l270"><li id="ch2.lt958" class="half_rhythm"><div>Young people aged 5–11 years with mild depression</div></li><li id="ch2.lt959" class="half_rhythm"><div>Young people aged 5–11 years with moderate to severe depression</div></li></ul>
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<b>Interventions:</b>
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<ul id="ch2.l271"><li id="ch2.lt960" class="half_rhythm"><div>Psychological therapies</div></li></ul>
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<b>Comparators:</b>
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<ul id="ch2.l272"><li id="ch2.lt961" class="half_rhythm"><div>Control intervention (waiting list, no treatment, monitoring or usual care)</div></li><li id="ch2.lt962" class="half_rhythm"><div>Other psychological therapies</div></li></ul>
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<b>Outcomes:</b>
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<ul id="ch2.l273"><li id="ch2.lt963" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt964" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt965" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt966" class="half_rhythm"><div>Quality of life</div></li><li id="ch2.lt967" class="half_rhythm"><div>Suicide ideation</div></li></ul></td></tr><tr><th id="hd_b_ch2.appn.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch2.appn.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a class="bibr" href="#ch2.appo.ref42" rid="ch2.appo.ref42">Lidle 1990</a>, <a class="bibr" href="#ch2.appo.ref63" rid="ch2.appo.ref63">Stark 1987</a>, <a class="bibr" href="#ch2.appo.ref77" rid="ch2.appo.ref77">Weisz 1997</a>, <a class="bibr" href="#ch2.appo.ref78" rid="ch2.appo.ref78">Weisz 2009</a>, <a class="bibr" href="#ch2.appo.ref18" rid="ch2.appo.ref18">Dietz 2015</a>, <a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a> and <a class="bibr" href="#ch2.appo.ref70" rid="ch2.appo.ref70">Tompson 2017</a></td></tr><tr><th id="hd_b_ch2.appn.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch2.appn.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised controlled trial</td></tr><tr><th id="hd_b_ch2.appn.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch2.appn.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l274"><li id="ch2.lt968" class="half_rhythm"><div>This RCT should be carried out within the UK.</div></li><li id="ch2.lt969" class="half_rhythm"><div>The study should be powered to detect the superiority of the interventions over the comparators.
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<ul id="ch2.l275"><li id="ch2.lt970" class="half_rhythm"><div>Subgroup analyses should include:
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<ul id="ch2.l276" class="circle"><li id="ch2.lt971" class="half_rhythm"><div>Sex</div></li><li id="ch2.lt972" class="half_rhythm"><div>Environment and family situation (for example, young people with chaotic family lives compared to those without; young people in prison or those who are looked after)</div></li><li id="ch2.lt973" class="half_rhythm"><div>Neurodevelopmental disorders</div></li></ul></div></li></ul></div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appntab2"><div id="ch2.appn.tab2" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appn.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appn.tab2_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.appn.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO</th><td headers="hd_b_ch2.appn.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><b>Population:</b></p><p>Young people aged 12 to 18 with mild depression</p><p><b>Interventions:</b>
|
|
<ul id="ch2.l277"><li id="ch2.lt974" class="half_rhythm"><div>Supported digital CBT</div></li></ul></p>
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<b>Comparator:</b>
|
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<ul id="ch2.l278"><li id="ch2.lt975" class="half_rhythm"><div>Unsupported digital CBT</div></li></ul>
|
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<b>Outcomes:</b>
|
|
<ul id="ch2.l279"><li id="ch2.lt976" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt977" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt978" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt979" class="half_rhythm"><div>Quality of life</div></li><li id="ch2.lt980" class="half_rhythm"><div>Suicide ideation</div></li></ul></td></tr><tr><th id="hd_b_ch2.appn.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch2.appn.tab2_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No evidence was identified that addressed this research question</td></tr><tr><th id="hd_b_ch2.appn.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch2.appn.tab2_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised controlled trial</td></tr><tr><th id="hd_b_ch2.appn.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch2.appn.tab2_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l280"><li id="ch2.lt981" class="half_rhythm"><div>This RCT should be carried out within the UK.</div></li><li id="ch2.lt982" class="half_rhythm"><div>The study should be powered to detect the superiority of supported CBT compared to unsupported CBT.</div></li><li id="ch2.lt983" class="half_rhythm"><div>Subgroup analyses should include:
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<ul id="ch2.l281" class="circle"><li id="ch2.lt984" class="half_rhythm"><div>Sex</div></li><li id="ch2.lt985" class="half_rhythm"><div>Environment and family situation (for example, young people with chaotic family lives compared to those without; young people in prison or those who are looked after)</div></li><li id="ch2.lt986" class="half_rhythm"><div>Neurodevelopmental disorders</div></li></ul></div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appntab3"><div id="ch2.appn.tab3" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appn.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appn.tab3_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.appn.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO</th><td headers="hd_b_ch2.appn.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><b>Population:</b></p><p>Young people aged 12 to 18 years with moderate to severe depression</p><p><b>Interventions:</b>
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<ul id="ch2.l282"><li id="ch2.lt987" class="half_rhythm"><div>IPT-A (IPT for adolescents)</div></li><li id="ch2.lt988" class="half_rhythm"><div>psychodynamic psychotherapy</div></li><li id="ch2.lt989" class="half_rhythm"><div>family therapy</div></li></ul></p>
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<p><b>Comparators:</b>
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<ul id="ch2.l283"><li id="ch2.lt990" class="half_rhythm"><div>Each other</div></li><li id="ch2.lt991" class="half_rhythm"><div>Individual CBT</div></li></ul></p>
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<p><b>Outcomes:</b>
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<ul id="ch2.l284"><li id="ch2.lt992" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt993" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt994" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt995" class="half_rhythm"><div>Quality of life</div></li><li id="ch2.lt996" class="half_rhythm"><div>Suicide ideation</div></li></ul></p></td></tr><tr><th id="hd_b_ch2.appn.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch2.appn.tab3_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><a class="bibr" href="#ch2.appo.ref72" rid="ch2.appo.ref72">Trowell 2007</a>, <a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>, <a class="bibr" href="#ch2.appo.ref48" rid="ch2.appo.ref48">Mufson 1999</a>, <a class="bibr" href="#ch2.appo.ref49" rid="ch2.appo.ref49">Mufson 2004</a>, <a class="bibr" href="#ch2.appo.ref57" rid="ch2.appo.ref57">Rossello 1999</a> and <a class="bibr" href="#ch2.appo.ref51" rid="ch2.appo.ref51">O’Shea 2015</a></td></tr><tr><th id="hd_b_ch2.appn.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch2.appn.tab3_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised controlled trial</td></tr><tr><th id="hd_b_ch2.appn.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch2.appn.tab3_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l285"><li id="ch2.lt997" class="half_rhythm"><div>This RCT should be carried out within the UK.</div></li><li id="ch2.lt998" class="half_rhythm"><div>The study should be powered to detect the superiority of the interventions over the comparators.</div></li><li id="ch2.lt999" class="half_rhythm"><div>Subgroup analyses should include:
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<ul id="ch2.l286" class="circle"><li id="ch2.lt1000" class="half_rhythm"><div>Gender</div></li><li id="ch2.lt1001" class="half_rhythm"><div>Environment and family situation (for example, young people with chaotic family lives compared to those without; young people in prison or those who are looked after)</div></li><li id="ch2.lt1002" class="half_rhythm"><div>Neurodevelopmental disorders</div></li></ul></div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appntab4"><div id="ch2.appn.tab4" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appn.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appn.tab4_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.appn.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO</th><td headers="hd_b_ch2.appn.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Population:</b>
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<ul id="ch2.l287"><li id="ch2.lt1003" class="half_rhythm"><div>Young people aged 12 to 18 years with mild depression</div></li><li id="ch2.lt1004" class="half_rhythm"><div>Young people aged 12 to 18 years moderate to severe depression</div></li></ul>
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<b>Interventions:</b>
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<ul id="ch2.l288"><li id="ch2.lt1005" class="half_rhythm"><div>Brief psychosocial intervention delivered by practitioners outside the specialist setting (including primary care)</div></li></ul>
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<b>Comparators:</b>
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<ul id="ch2.l289"><li id="ch2.lt1006" class="half_rhythm"><div>Control intervention (waiting list, no treatment, monitoring or usual care)</div></li><li id="ch2.lt1007" class="half_rhythm"><div>Other psychological therapies</div></li></ul>
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<b>Outcomes:</b>
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<ul id="ch2.l290"><li id="ch2.lt1008" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt1009" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt1010" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt1011" class="half_rhythm"><div>Quality of life</div></li><li id="ch2.lt1012" class="half_rhythm"><div>Suicide ideation</div></li></ul></td></tr><tr><th id="hd_b_ch2.appn.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch2.appn.tab4_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This research question is based on the findings of 1 RCT (IMPACT trial, <a class="bibr" href="#ch2.appo.ref27" rid="ch2.appo.ref27">Goodyer 2017</a>)</td></tr><tr><th id="hd_b_ch2.appn.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch2.appn.tab4_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised controlled trial</td></tr><tr><th id="hd_b_ch2.appn.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch2.appn.tab4_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l291"><li id="ch2.lt1013" class="half_rhythm"><div>This RCT should be carried out within the UK.</div></li><li id="ch2.lt1014" class="half_rhythm"><div>The study should be powered to detect the superiority of BPI over the comparators.</div></li><li id="ch2.lt1015" class="half_rhythm"><div>Subgroup analyses should include:
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<ul id="ch2.l292" class="circle"><li id="ch2.lt1016" class="half_rhythm"><div>Sex</div></li><li id="ch2.lt1017" class="half_rhythm"><div>Environment and family situation (for example, young people with chaotic family lives compared to those without; young people in prison or those who are looked after)</div></li><li id="ch2.lt1018" class="half_rhythm"><div>Neurodevelopmental disorders</div></li></ul></div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appntab5"><div id="ch2.appn.tab5" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appn.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appn.tab5_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.appn.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO</th><td headers="hd_b_ch2.appn.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Population:</b>
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|
<ul id="ch2.l293"><li id="ch2.lt1019" class="half_rhythm"><div>Children aged 5–11 years with mild depression</div></li><li id="ch2.lt1020" class="half_rhythm"><div>Children aged 5–11 years with moderate to severe depression</div></li><li id="ch2.lt1021" class="half_rhythm"><div>Young people aged 12 to 18 years with mild depression</div></li><li id="ch2.lt1022" class="half_rhythm"><div>Young people aged 12 to 18 years with moderate to severe depression</div></li></ul>
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<b>Interventions:</b>
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|
<ul id="ch2.l294"><li id="ch2.lt1023" class="half_rhythm"><div>Behavioural activation</div></li></ul>
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<b>Comparator:</b>
|
|
<ul id="ch2.l295"><li id="ch2.lt1024" class="half_rhythm"><div>Other psychological therapies</div></li></ul>
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<b>Outcomes:</b>
|
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<ul id="ch2.l296"><li id="ch2.lt1025" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt1026" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt1027" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt1028" class="half_rhythm"><div>Quality of life</div></li><li id="ch2.lt1029" class="half_rhythm"><div>Suicide ideation</div></li></ul></td></tr><tr><th id="hd_b_ch2.appn.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch2.appn.tab5_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This research question is based on the findings of 1 RCT (<a class="bibr" href="#ch2.appo.ref46" rid="ch2.appo.ref46">McCauley 2016</a>)</td></tr><tr><th id="hd_b_ch2.appn.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch2.appn.tab5_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised controlled trial</td></tr><tr><th id="hd_b_ch2.appn.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch2.appn.tab5_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l297"><li id="ch2.lt1030" class="half_rhythm"><div>This RCT should be carried out within the UK.</div></li><li id="ch2.lt1031" class="half_rhythm"><div>The study should be powered to detect the superiority of behavioural activation over the comparators.</div></li><li id="ch2.lt1032" class="half_rhythm"><div>Subgroup analyses should include:
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<ul id="ch2.l298" class="circle"><li id="ch2.lt1033" class="half_rhythm"><div>Gender</div></li><li id="ch2.lt1034" class="half_rhythm"><div>Environment and family situation (for example, young people with chaotic family lives compared to those without; young people in prison or those who are looked after)</div></li><li id="ch2.lt1035" class="half_rhythm"><div>Neurodevelopmental disorders</div></li></ul></div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appntab6"><div id="ch2.appn.tab6" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appn.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appn.tab6_lrgtbl__"><table><tbody><tr><th id="hd_b_ch2.appn.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PICO</th><td headers="hd_b_ch2.appn.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Population:</b>
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|
<ul id="ch2.l299"><li id="ch2.lt1036" class="half_rhythm"><div>Young people aged 12 to 18 years with mild depression</div></li></ul>
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<b>Interventions:</b>
|
|
<ul id="ch2.l300"><li id="ch2.lt1037" class="half_rhythm"><div>Group mindfulness</div></li></ul>
|
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<b>Comparator:</b>
|
|
<ul id="ch2.l301"><li id="ch2.lt1038" class="half_rhythm"><div>Other psychological therapies</div></li></ul>
|
|
<b>Outcomes:</b>
|
|
<ul id="ch2.l302"><li id="ch2.lt1039" class="half_rhythm"><div>Depression symptoms</div></li><li id="ch2.lt1040" class="half_rhythm"><div>Functional status</div></li><li id="ch2.lt1041" class="half_rhythm"><div>Remission</div></li><li id="ch2.lt1042" class="half_rhythm"><div>Quality of life</div></li><li id="ch2.lt1043" class="half_rhythm"><div>Suicide ideation</div></li></ul></td></tr><tr><th id="hd_b_ch2.appn.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Current evidence base</th><td headers="hd_b_ch2.appn.tab6_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This research question is based on the findings of 1 RCT (<a class="bibr" href="#ch2.appo.ref59" rid="ch2.appo.ref59">Shomaker 2017</a>)</td></tr><tr><th id="hd_b_ch2.appn.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design</th><td headers="hd_b_ch2.appn.tab6_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Randomised controlled trial</td></tr><tr><th id="hd_b_ch2.appn.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other comments</th><td headers="hd_b_ch2.appn.tab6_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul id="ch2.l303"><li id="ch2.lt1044" class="half_rhythm"><div>This RCT should be carried out within the UK.</div></li><li id="ch2.lt1045" class="half_rhythm"><div>The study should be powered to detect the superiority of group mindfulness over the comparators.</div></li><li id="ch2.lt1046" class="half_rhythm"><div>Subgroup analyses should include:
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<ul id="ch2.l304" class="circle"><li id="ch2.lt1047" class="half_rhythm"><div>Gender</div></li><li id="ch2.lt1048" class="half_rhythm"><div>Environment and family situation (for example, young people with chaotic family lives compared to those without; young people in prison or those who are looked after)</div></li><li id="ch2.lt1049" class="half_rhythm"><div>Neurodevelopmental disorders</div></li></ul></div></li></ul></td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appptab1"><div id="ch2.appp.tab1" class="table"><h3><span class="label">Table 41</span><span class="title">Rating scales used in included studies</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appp.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appp.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Outcome assessed</th><th id="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Scale</th><th id="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Variants</th><th id="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Description</th><th id="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Intended age range</th><th id="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Rating scale</th></tr></thead><tbody><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Practitioner and parent tool, self-rated tool</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life measure focusing on general health and social functioning for use in child and adolescent mental health services.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>5–18 years</p>
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<p>13–18 years</p>
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<p>(self-rated tool)</p>
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</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>0–52</p>
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<p>or</p>
|
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<p>0–60</p>
|
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</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Functional status</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Global assessment of function (GAF)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rating of social, occupational, and psychological functioning (not specific to depression). Higher scores indicate better function.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adults</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 to 100</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Functional status</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Children’s global assessment scale (CGAS)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adaptation of the adult global assessment of function. Higher scores indicate better function.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Under 18</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>1 to 90</p>
|
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<p>or</p>
|
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<p>1 to 100</p>
|
|
</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Beck depression inventory (BDI)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BDI-1A, BDI-II</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-report measure of depression severity at current time. Higher scores indicate more depression symptoms.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13+</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 to 63</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Child depression inventory (CDI)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CDI-II, long, short, parent and teacher versions</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adaptation of the adult Beck depression inventory. Higher scores indicate more depression symptoms.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7–17</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 to 54</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reynolds adolescent depression scale (RADS)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RADS-2, RADS-short form</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-report questionnaire that aims to identify and quantify depressive symptoms in adolescents (gives score representing severity of depressive symptoms). Higher scores indicate more depression symptoms.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13–18</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30 to 120</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mood and feelings questionnaire (MFQ)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Short-MFQ, Parent MFQ-P, Child MFQ-C</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-report questionnaire that aims to assess depressive symptoms. Higher scores indicate more depression symptoms.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8–17</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>Short version: 0 to 26</p>
|
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<p>Long version: 0 to 66</p>
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</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Center for epidemiological studies depression scale (CES-D)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CES-D-R (revised version)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Self-report questionnaire designed to measure depressive symptoms in the past week in the general population (designed for epidemiological studies). Higher scores indicate more depression symptoms.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adults</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 to 60</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms, remission</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schedule for Affective disorders and Schizophrenia for school-age children (K-SADS)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Present and lifetime version (K-SADS-PL); K-SADS-E interview</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Structured diagnostic interview for range of psychiatric disorders including major depressive disorder. Can also be used to assess symptom severity, but is time consuming so may be inefficient as a way of measuring changes in symptoms. Higher scores indicate more depression symptoms.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6–17</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 to 3 (rating scale unclear).</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms, remission</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hamilton rating scale for depression (HAM-D)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Also abbreviated to HDRS or HRSD</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Structured interview that determines the presence and severity of depression. Higher scores indicate more depression symptoms.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adults</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17 to 29 items depending on the version; scored either on a 3-point or 5-point Likert-scale</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms, remission</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Child depression rating scale (CDRS)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CDRS-R (revised version)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adaptation of the Hamilton rating scale for depression for adults. Higher scores indicate more depression symptoms.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6–12</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CDRS-R: 17 to 113 (rating scale unclear).</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bellevue index of depression, BID</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Scale developed at Bellevue psychiatric hospital</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6 to 12 ½</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 to 120</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Suicidal ideation</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">K-SADS suicide symptom total score</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">See entry for K-SADS under depression symptoms, remission</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6–17</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rating scale unclear)</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Suicidal ideation</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Suicidal ideation questionnaire - Junior version (SIQ-JR)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15-item questionnaire to assess suicidal ideation. Higher scores indicate greater suicidal ideation.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adolescents</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15 items (rating scale unclear).</td></tr><tr><td headers="hd_h_ch2.appp.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Suicidal ideation</td><td headers="hd_h_ch2.appp.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Scale for suicidal ideation (SSI)</td><td headers="hd_h_ch2.appp.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_ch2.appp.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19 item clinician rating scale to assess suicidal ideation. Higher scores indicate greater suicidal ideation.</td><td headers="hd_h_ch2.appp.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Adults</td><td headers="hd_h_ch2.appp.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0 to 38</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appqtab1"><div id="ch2.appq.tab1" class="table"><h3><span class="label">Table 42</span><span class="title"><b>List scales used in included studies with ranking for data extraction.</b> Results for depression symptoms were back converted onto the Child Depression Inventory (CDI), the Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA) was used for quality of life and the Children’s Global Assessment Scale (CGAS) was used for level of function</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.appq.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.appq.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.appq.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">List of scales per outcome</th><th id="hd_h_ch2.appq.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Abbreviation</th><th id="hd_h_ch2.appq.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Number of studies</th><th id="hd_h_ch2.appq.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Ranking</th><th id="hd_h_ch2.appq.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Clinician or self-reported</th><th id="hd_h_ch2.appq.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Direction of scale</th></tr></thead><tbody><tr><th headers="hd_h_ch2.appq.tab1_1_1_1_1" id="hd_b_ch2.appq.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<i>Level of function</i>
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</th><th headers="hd_h_ch2.appq.tab1_1_1_1_2" id="hd_b_ch2.appq.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_3" id="hd_b_ch2.appq.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_4" id="hd_b_ch2.appq.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_5" id="hd_b_ch2.appq.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_6" id="hd_b_ch2.appq.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Children’s global assessment scale</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CGAS</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Higher values better level of function</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Global assessment of functioning</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">GAF</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Higher values better level of function</td></tr><tr><th headers="hd_h_ch2.appq.tab1_1_1_1_1" id="hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<i>Depression</i>
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</th><th headers="hd_h_ch2.appq.tab1_1_1_1_2" id="hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_3" id="hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_4" id="hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_5" id="hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_6" id="hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Child depression rating scale-revised</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CDRS-R</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Child depression Inventory</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CDI</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> CDI-child reported</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CDI-C</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> CDI-parent reported</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CDI-P</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Beck Depression inventory</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BDI</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> BDI in line with DSM-IV</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BDI-II</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hamilton rating scale for depression also known as HRSD</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HAM-D/HRSD</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Centre for epidemiological studies depression scale</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CES-D</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> CESD-children</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CESD-C</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> CESD-parent</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CESD-P</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> CESD-revised</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CESD-R</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> CESD-youth</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CESD-Y</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mood and feelings questionnaire</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MFQ</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> MFQ-child</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MFQ-C</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> MFQ-parent</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MFQ-P</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Short-MFQ</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SMFQ</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reynolds adolescent depression scale</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RADS</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> RADS-version 2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RADS-2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> RADS-short form</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RCADS</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schedule for Affective disorders and Schizophrenia for schoolage children</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">K-SADS</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Preschool Feelings Checklist-scale version 21-item adaptation</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PFC-S</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quick inventory of depressive symptomatology-adolescent version</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_4_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">QIDS-A-Pat</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_4_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_4_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_4_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_4_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values fewer depression symptoms</td></tr><tr><th headers="hd_h_ch2.appq.tab1_1_1_1_1" id="hd_b_ch2.appq.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<i>Quality of life</i>
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</th><th headers="hd_h_ch2.appq.tab1_1_1_1_2" id="hd_b_ch2.appq.tab1_1_1_27_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_3" id="hd_b_ch2.appq.tab1_1_1_27_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_4" id="hd_b_ch2.appq.tab1_1_1_27_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_5" id="hd_b_ch2.appq.tab1_1_1_27_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_6" id="hd_b_ch2.appq.tab1_1_1_27_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Health of the nation outcome scales for children and adolescents</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_27_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">HoNOSCA</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_27_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_27_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_27_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_27_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values better quality of life</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paediatric Quality of Life Enjoyment and Satisfaction Questionnaire</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_27_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PQ-LES-Q</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_27_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_27_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_27_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_27_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Higher values better quality of life</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paediatric Quality of Life Inventory</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_27_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PEDS-QL</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_27_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_27_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_27_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_27_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Higher values better quality of life</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EuroQol five dimensions questionnaire</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_27_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EQ-5D</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_27_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_27_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_27_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_27_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Higher values better quality of life</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> EQ-5D-youth</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_27_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EQ-5D-Y</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_27_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_27_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_27_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_27_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Higher values better quality of life</td></tr><tr><th headers="hd_h_ch2.appq.tab1_1_1_1_1" id="hd_b_ch2.appq.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<i>Suicidal ideation – continuous</i>
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</th><th headers="hd_h_ch2.appq.tab1_1_1_1_2" id="hd_b_ch2.appq.tab1_1_1_33_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_3" id="hd_b_ch2.appq.tab1_1_1_33_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_4" id="hd_b_ch2.appq.tab1_1_1_33_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_5" id="hd_b_ch2.appq.tab1_1_1_33_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_6" id="hd_b_ch2.appq.tab1_1_1_33_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Suicide ideation questionnaire</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_33_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SIQ</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_33_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_33_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_33_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_33_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values less suicidal ideation</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> SIQ-junior version</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_33_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SIQ-JR</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_33_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_33_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_33_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_33_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values less suicidal ideation</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Scale for suicidal ideation</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_33_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SSI</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_33_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_33_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_33_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_33_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values less suicidal ideation</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Only item 9 of BDI</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_33_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BDI (item 9)</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_33_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_33_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_33_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_33_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values less suicidal ideation</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schedule for Affective disorders and Schizophrenia for schoolage children</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_33_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">K-SADS</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_33_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_33_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_33_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_33_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values less suicidal ideation</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> K-SADS-interview version</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_33_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">K-SADS-E</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_33_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_33_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_33_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_33_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values less suicidal ideation</td></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> K-SADS-present and lifetime version</td><td headers="hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_33_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">K-SADS-P/E</td><td headers="hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_33_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_33_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_33_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td><td headers="hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_33_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lower values less suicidal ideation</td></tr><tr><th headers="hd_h_ch2.appq.tab1_1_1_1_1" id="hd_b_ch2.appq.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<i>Self-harm</i>
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</th><th headers="hd_h_ch2.appq.tab1_1_1_1_2" id="hd_b_ch2.appq.tab1_1_1_41_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_3" id="hd_b_ch2.appq.tab1_1_1_41_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_4" id="hd_b_ch2.appq.tab1_1_1_41_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_5" id="hd_b_ch2.appq.tab1_1_1_41_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th><th headers="hd_h_ch2.appq.tab1_1_1_1_6" id="hd_b_ch2.appq.tab1_1_1_41_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></th></tr><tr><td headers="hd_h_ch2.appq.tab1_1_1_1_1 hd_b_ch2.appq.tab1_1_1_41_1 hd_h_ch2.appq.tab1_1_1_1_2 hd_b_ch2.appq.tab1_1_1_41_2 hd_h_ch2.appq.tab1_1_1_1_3 hd_b_ch2.appq.tab1_1_1_41_3 hd_h_ch2.appq.tab1_1_1_1_4 hd_b_ch2.appq.tab1_1_1_41_4 hd_h_ch2.appq.tab1_1_1_1_5 hd_b_ch2.appq.tab1_1_1_41_5 hd_h_ch2.appq.tab1_1_1_1_6 hd_b_ch2.appq.tab1_1_1_41_6" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">Only 1 study reported self-harm as a dichotomous outcome: thoughts of deliberate self-harm (Y/N); deliberate self-harm behaviour (Y/N)</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appstab1"><div id="ch2.apps.tab1" class="table"><h3><span class="label">Table 43</span><span class="title">Networks where inconsistency checks were not possible</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apps.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apps.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcome</th><th id="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Age Group</th><th id="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Severity of Depression</th></tr></thead><tbody><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms, post-treatment</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 to 11 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms, ≤ 6 months</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Depression symptoms, >6 to ≤ 18 months</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mild</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">Functional status, post-treatment</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 to 11 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mild</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">Functional status, ≤ 6 months</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mild</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Functional status, >6 to ≤ 18 months</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">Remission, post-treatment</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 to 11 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mild</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life, post-treatment</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life, ≤ 6 months</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Quality of life, >6 to ≤ 18 months</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="3" colspan="1" style="text-align:left;vertical-align:top;">Suicide ideation, post-treatment</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 to 11 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:top;">12 to 18 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mild</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr><tr><td headers="hd_h_ch2.apps.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Discontinuation, endpoint</td><td headers="hd_h_ch2.apps.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5 to 11 years</td><td headers="hd_h_ch2.apps.tab1_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Moderate to severe</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobch2appstab2"><div id="ch2.apps.tab2" class="table"><h3><span class="label">Table 44</span><span class="title">Model fit statistics for ‘Depression symptoms, post-treatment’, 12 to 18 year olds with mild depression</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apps.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apps.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apps.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Model</th><th id="hd_h_ch2.apps.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Between Study Heterogeneity - Standard Deviation (95% CrI<sup>a</sup>)</th><th id="hd_h_ch2.apps.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Posterior total residual deviance<sup>b</sup></th><th id="hd_h_ch2.apps.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DIC<sup>c</sup></th></tr></thead><tbody><tr><td headers="hd_h_ch2.apps.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Consistency model - RE</td><td headers="hd_h_ch2.apps.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.35 (0.19, 0.59)</td><td headers="hd_h_ch2.apps.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.13</td><td headers="hd_h_ch2.apps.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">263.690</td></tr><tr><td headers="hd_h_ch2.apps.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency model - RE</td><td headers="hd_h_ch2.apps.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.23 (0.06, 0.48)</td><td headers="hd_h_ch2.apps.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62.97</td><td headers="hd_h_ch2.apps.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">263.258</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.apps.tab2_1"><p class="no_margin">Credible Interval (CrI)</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.apps.tab2_2"><p class="no_margin">Posterior mean residual deviance compared to 60 total data points</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.apps.tab2_3"><p class="no_margin">Deviance information criteria (DIC) – lower values preferred</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobch2appsfig1"><div id="ch2.apps.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20121.%20Deviance%20contributions%20for%20the%20random%20effects%20consistency%20and%20inconsistency%20models.&p=BOOKS&id=557360_ch2appsf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appsf1.jpg" alt="Figure 121. Deviance contributions for the random effects consistency and inconsistency models." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 121</span><span class="title">Deviance contributions for the random effects consistency and inconsistency models</span></h3></div></article><article data-type="table-wrap" id="figobch2appstab3"><div id="ch2.apps.tab3" class="table"><h3><span class="label">Table 45</span><span class="title">Model fit statistics for ‘Depression symptoms, post-treatment’, 12 to 18 year olds with moderate to severe depression</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apps.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apps.tab3_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apps.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Model</th><th id="hd_h_ch2.apps.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Between Study Heterogeneity - Standard Deviation (95% CrI<sup>a</sup>)</th><th id="hd_h_ch2.apps.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Posterior total residual deviance<sup>b</sup></th><th id="hd_h_ch2.apps.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DIC<sup>c</sup></th></tr></thead><tbody><tr><td headers="hd_h_ch2.apps.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Consistency model - RE</td><td headers="hd_h_ch2.apps.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.54 (0.29, 1.04)</td><td headers="hd_h_ch2.apps.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.63</td><td headers="hd_h_ch2.apps.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">250.859</td></tr><tr><td headers="hd_h_ch2.apps.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency model - RE</td><td headers="hd_h_ch2.apps.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.65 (0.34, 1.43)</td><td headers="hd_h_ch2.apps.tab3_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51.02</td><td headers="hd_h_ch2.apps.tab3_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">251.007</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.apps.tab3_1"><p class="no_margin">Credible Interval (CrI)</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.apps.tab3_2"><p class="no_margin">Posterior mean residual deviance compared to 51 total data points</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.apps.tab3_3"><p class="no_margin">Deviance information criteria (DIC) – lower values preferred</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobch2appsfig2"><div id="ch2.apps.fig2" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20122.%20Deviance%20contributions%20for%20the%20random%20effects%20consistency%20and%20inconsistency%20models.&p=BOOKS&id=557360_ch2appsf2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appsf2.jpg" alt="Figure 122. Deviance contributions for the random effects consistency and inconsistency models." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 122</span><span class="title">Deviance contributions for the random effects consistency and inconsistency models</span></h3></div></article><article data-type="table-wrap" id="figobch2appstab4"><div id="ch2.apps.tab4" class="table"><h3><span class="label">Table 46</span><span class="title">Model fit statistics for ‘Depression symptoms, ≤ 6 months’, 12 to 18 year olds with mild depression</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apps.tab4/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apps.tab4_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apps.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Model</th><th id="hd_h_ch2.apps.tab4_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Between Study Heterogeneity - Standard Deviation (95% CrI<sup>a</sup>)</th><th id="hd_h_ch2.apps.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Posterior total residual deviance<sup>b</sup></th><th id="hd_h_ch2.apps.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DIC<sup>c</sup></th></tr></thead><tbody><tr><td headers="hd_h_ch2.apps.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Consistency model - FE</td><td headers="hd_h_ch2.apps.tab4_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">N/A</td><td headers="hd_h_ch2.apps.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68.37</td><td headers="hd_h_ch2.apps.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">239.540</td></tr><tr><td headers="hd_h_ch2.apps.tab4_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency model - FE</td><td headers="hd_h_ch2.apps.tab4_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64.0</td><td headers="hd_h_ch2.apps.tab4_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">238.184</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.apps.tab4_1"><p class="no_margin">Credible Interval (CrI)</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.apps.tab4_2"><p class="no_margin">Posterior mean residual deviance compared to 52 total data points</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.apps.tab4_3"><p class="no_margin">Deviance information criteria (DIC) – lower values preferred</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobch2appsfig3"><div id="ch2.apps.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20123.%20Deviance%20contributions%20for%20the%20fixed%20effect%20consistency%20and%20inconsistency%20models.&p=BOOKS&id=557360_ch2appsf3.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appsf3.jpg" alt="Figure 123. Deviance contributions for the fixed effect consistency and inconsistency models." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 123</span><span class="title">Deviance contributions for the fixed effect consistency and inconsistency models</span></h3></div></article><article data-type="table-wrap" id="figobch2appstab5"><div id="ch2.apps.tab5" class="table"><h3><span class="label">Table 47</span><span class="title">Model fit statistics for ‘Functional status >6 to ≤ 18 months’, 12 to 18 year olds with mild depression</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apps.tab5/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apps.tab5_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apps.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Model</th><th id="hd_h_ch2.apps.tab5_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Between Study Heterogeneity - Standard Deviation (95% CrI<sup>a</sup>)</th><th id="hd_h_ch2.apps.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Posterior total residual deviance<sup>b</sup></th><th id="hd_h_ch2.apps.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DIC<sup>c</sup></th></tr></thead><tbody><tr><td headers="hd_h_ch2.apps.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Consistency model - FE</td><td headers="hd_h_ch2.apps.tab5_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">N/A</td><td headers="hd_h_ch2.apps.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.135</td><td headers="hd_h_ch2.apps.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25.902</td></tr><tr><td headers="hd_h_ch2.apps.tab5_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency model - FE</td><td headers="hd_h_ch2.apps.tab5_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5.971</td><td headers="hd_h_ch2.apps.tab5_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27.707</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.apps.tab5_1"><p class="no_margin">Credible Interval (CrI)</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.apps.tab5_2"><p class="no_margin">Posterior mean residual deviance compared to 6 total data points</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.apps.tab5_3"><p class="no_margin">Deviance information criteria (DIC) – lower values preferred</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobch2appsfig4"><div id="ch2.apps.fig4" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20124.%20Deviance%20contributions%20for%20the%20fixed%20effect%20consistency%20and%20inconsistency%20models.&p=BOOKS&id=557360_ch2appsf4.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appsf4.jpg" alt="Figure 124. Deviance contributions for the fixed effect consistency and inconsistency models." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 124</span><span class="title">Deviance contributions for the fixed effect consistency and inconsistency models</span></h3></div></article><article data-type="table-wrap" id="figobch2appstab6"><div id="ch2.apps.tab6" class="table"><h3><span class="label">Table 48</span><span class="title">Model fit statistics for ‘Discontinuation for any reason, end point’, 12 to 18 year olds with mild depression</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apps.tab6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apps.tab6_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apps.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Model<sup>*</sup></th><th id="hd_h_ch2.apps.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Between Study Heterogeneity - Standard Deviation (95% CrI<sup>a</sup>)</th><th id="hd_h_ch2.apps.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Posterior total residual deviance<sup>b</sup></th><th id="hd_h_ch2.apps.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DIC<sup>c</sup></th></tr></thead><tbody><tr><td headers="hd_h_ch2.apps.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Consistency model - RE</td><td headers="hd_h_ch2.apps.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.77 (0.17, 1.78)</td><td headers="hd_h_ch2.apps.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54.36</td><td headers="hd_h_ch2.apps.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">255.066</td></tr><tr><td headers="hd_h_ch2.apps.tab6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency model - RE</td><td headers="hd_h_ch2.apps.tab6_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">0.96 (0.29, 2.42)</td><td headers="hd_h_ch2.apps.tab6_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50.71</td><td headers="hd_h_ch2.apps.tab6_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">252.876</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.apps.tab6_1"><p class="no_margin">Credible Interval (CrI)</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.apps.tab6_2"><p class="no_margin">Posterior mean residual deviance compared to 48 total data points</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.apps.tab6_3"><p class="no_margin">Deviance information criteria (DIC) – lower values preferred</p></div></dd></dl><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apps.tab6_4"><p class="no_margin">Thin = 10</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobch2appsfig5"><div id="ch2.apps.fig5" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20125.%20Deviance%20contributions%20for%20the%20random%20effects%20consistency%20and%20inconsistency%20models.&p=BOOKS&id=557360_ch2appsf5.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appsf5.jpg" alt="Figure 125. Deviance contributions for the random effects consistency and inconsistency models." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 125</span><span class="title">Deviance contributions for the random effects consistency and inconsistency models</span></h3></div></article><article data-type="table-wrap" id="figobch2appstab7"><div id="ch2.apps.tab7" class="table"><h3><span class="label">Table 49</span><span class="title">Model fit statistics for ‘Discontinuation for any reason, end point, 12 to 18 year olds with moderate to severe depression</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK557360/table/ch2.apps.tab7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__ch2.apps.tab7_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_ch2.apps.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Model<sup>*</sup></th><th id="hd_h_ch2.apps.tab7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Between Study Heterogeneity - Standard Deviation (95% CrI<sup>a</sup>)</th><th id="hd_h_ch2.apps.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Posterior total residual deviance<sup>b</sup></th><th id="hd_h_ch2.apps.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DIC<sup>c</sup></th></tr></thead><tbody><tr><td headers="hd_h_ch2.apps.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Consistency model - FE</td><td headers="hd_h_ch2.apps.tab7_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">N/A</td><td headers="hd_h_ch2.apps.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42.24</td><td headers="hd_h_ch2.apps.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">218.248</td></tr><tr><td headers="hd_h_ch2.apps.tab7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inconsistency model - FE</td><td headers="hd_h_ch2.apps.tab7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43.96</td><td headers="hd_h_ch2.apps.tab7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">221.901</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="ch2.apps.tab7_1"><p class="no_margin">Credible Interval (CrI)</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="ch2.apps.tab7_2"><p class="no_margin">Posterior mean residual deviance compared to 45 total data points</p></div></dd></dl><dl class="bkr_refwrap"><dt>c</dt><dd><div id="ch2.apps.tab7_3"><p class="no_margin">Deviance information criteria (DIC) – lower values preferred</p></div></dd></dl><dl class="bkr_refwrap"><dt>*</dt><dd><div id="ch2.apps.tab7_4"><p class="no_margin">Continuity correction applied. Thin = 10.</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobch2appsfig6"><div id="ch2.apps.fig6" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%20126.%20Deviance%20contributions%20for%20the%20fixed%20effect%20consistency%20and%20inconsistency%20models.&p=BOOKS&id=557360_ch2appsf6.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK557360/bin/ch2appsf6.jpg" alt="Figure 126. Deviance contributions for the fixed effect consistency and inconsistency models." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 126</span><span class="title">Deviance contributions for the fixed effect consistency and inconsistency models</span></h3></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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