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<meta name="citation_keywords" content="1-(4-(1,1-Dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-1-butanone">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK556368_"><span class="title" itemprop="name">Ebastine</span></h1><p class="fm-aai"><a href="#_NBK556368_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 90729-43-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/403483390" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=403483390" alt="image 403483390 in the ncbi pubchem database" /></a><div id="ebastine.Drug_Levels_and_Effects"><h2 id="_ebastine_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="ebastine.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Ebastine is a nonsedating antihistamine that is not available in the United States, but is available in other countries. Preliminary evidence indicates that the amounts in milk are unlikely to affect a breastfed infant.</p></div><div id="ebastine.Drug_Levels"><h3>Drug Levels</h3><p>Ebastine is a pro-drug that is metabolized to the active metabolite, carebastine, which has a much longer half-life than ebastine.</p><p><i>Maternal Levels.</i> A woman with chronic urticaria was taking ebastine 10 mg daily during pregnancy and postpartum. On day 5 postpartum, the highest measured ebastine concentration in breastmilk was 6.3 mcg/L at 3.9 hours after the dose. The highest measured breastmilk carebastine concentration of 5.4 mcg/L occurred at 11.3 hours after administration. At 24.3 hours after the dose, the ebastine concentration was 1.1 mcg/L and the carebastine concentration was 4.4 mcg/L. Based on milk samples obtained at 11.3 hours after the dose, the authors estimated that a fully breastfed infant would receive daily dosages of 0.3 mcg/kg of ebastine and 0.2 mcg/kg of carebastine.[<a class="bibr" href="#ebastine.REF.1" rid="ebastine.REF.1">1</a>]</p><p><i>Infant Levels.</i> A woman with chronic urticaria was taking ebastine 10 mg daily during pregnancy and postpartum. At 24 hours after birth, her breastfed infant had an undetectable serum (<0.2 mcg/L) ebastine concentration and a carebastine concentration of 46.8 mcg/L, probably obtained via placental transfer. At 2 days postpartum, both ebastine and carebastine were undetectable in the infant’s serum.[<a class="bibr" href="#ebastine.REF.1" rid="ebastine.REF.1">1</a>]</p></div><div id="ebastine.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>A woman with chronic urticaria was taking ebastine 10 mg daily during pregnancy and postpartum. Her infant was exclusively breastfed until the age of 6 months. He showed normal development at 1 and 3 months of age.[<a class="bibr" href="#ebastine.REF.1" rid="ebastine.REF.1">1</a>]</p></div><div id="ebastine.Effects_on_Lactation_and_Breast"><h3>Effects on Lactation and Breastmilk</h3><p>Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[<a class="bibr" href="#ebastine.REF.2" rid="ebastine.REF.2">2</a>,<a class="bibr" href="#ebastine.REF.3" rid="ebastine.REF.3">3</a>] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[<a class="bibr" href="#ebastine.REF.2" rid="ebastine.REF.2">2</a>] Whether lower oral doses of antihistamines or ebastine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="ebastine.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM82/?report=reader">Desloratadine</a>, <a href="/books/n/lactmed/LM111/?report=reader">Fexofenadine</a>, <a href="/books/n/lactmed/LM163/?report=reader">Loratadine</a></p></div><div id="ebastine.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="ebastine.REF.1">Saito J, Yakuwa N, Sandaiji N, et al. Ebastine during pregnancy and lactation in a patient with chronic urticaria: Ebastine and carebastine levels in maternal serum, cord blood, breast milk, and the infant's serum. <span><span class="ref-journal">J Eur Acad Dermatol Venereol. </span>2020;<span class="ref-vol">34</span>:e496–e7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/32249465" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32249465</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="ebastine.REF.2">Messinis IE, Souvatzoglou A, Fais N, et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. <span><span class="ref-journal">J Endocrinol Invest. </span>1985;<span class="ref-vol">8</span>:143–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/3928731" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3928731</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="ebastine.REF.3">Pontiroli AE, De Castro e Silva E, Mazzoleni F, et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: Sex differences and the role of stress. <span><span class="ref-journal">J Clin Endocrinol Metab. </span>1981;<span class="ref-vol">52</span>:924–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7228996" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7228996</span></a>]</div></dd></dl></dl></div></div><div id="ebastine.Substance_Identification"><h2 id="_ebastine_Substance_Identification_">Substance Identification</h2><div id="ebastine.Substance_Name"><h3>Substance Name</h3><p>Ebastine</p></div><div id="ebastine.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>90729-43-4</p></div><div id="ebastine.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Antihistamines</p><p>Nonsedating Antihistamines</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK556368_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">September 20, 2021</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Ebastine. [Updated 2021 Sep 20].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM590/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/Ebola_vaccine/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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