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stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style"><div class="fm-sec bkr_bottom_sep"><div class="bkr_thumb"><a href="https://www.nice.org.uk" title="National Institute for Health and Care Excellence (NICE)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-niceng154er18-lrg.png" alt="Cover of Service design" /></a></div><div class="bkr_bib"><h1 id="_NBK555673_"><span itemprop="name">Service design</span></h1><div class="subtitle">Neonatal parenteral nutrition</div><p><b>Evidence review H</b></p><p><i>NICE Guideline, No. 154</i></p><p class="contrib-group"><h4>Authors</h4><span itemprop="author">National Guideline Alliance (UK)</span>.</p><div class="half_rhythm">London: <a href="https://www.nice.org.uk" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Institute for Health and Care Excellence (NICE)</span></a>; <span itemprop="datePublished">2020 Feb</span>.<div class="small">ISBN-13: <span itemprop="isbn">978-1-4731-3673-1</span></div></div><div><a href="/books/about/copyright/">Copyright</a> © NICE 2020.</div></div><div class="bkr_clear"></div></div><div id="niceng154er18.s1"><h2 id="_niceng154er18_s1_">Service Design</h2><div id="niceng154er18.s1.1"><h3>Review question</h3><p>Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</p><div id="niceng154er18.s1.1.1"><h4>Introduction</h4><p>Due to the complexity of providing parenteral nutrition (PN) to babies, multidisciplinary care teams that have a special understanding of their nutritional requirements could offer added expertise in ensuring adequate nutrition to avoid deficits and promote growth, whilst reducing the risks associated with PN. The aim of this review is to determine whether multidisciplinary teams (MDTS) are effective, safe and decrease the risk of PN complications.</p></div><div id="niceng154er18.s1.1.2"><h4>Summary of the protocol</h4><p>Please see <a class="figpopup" href="/books/NBK555673/table/niceng154er18.tab1/?report=objectonly" target="object" rid-figpopup="figniceng154er18tab1" rid-ob="figobniceng154er18tab1">Table 1</a> for a summary of the Population, Intervention, Comparison and Outcome (PICO) characteristics of this review.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figniceng154er18tab1"><a href="/books/NBK555673/table/niceng154er18.tab1/?report=objectonly" target="object" title="Table 1" class="img_link icnblk_img figpopup" rid-figpopup="figniceng154er18tab1" rid-ob="figobniceng154er18tab1"><img class="small-thumb" src="/books/NBK555673/table/niceng154er18.tab1/?report=thumb" src-large="/books/NBK555673/table/niceng154er18.tab1/?report=previmg" alt="Table 1. Summary of the protocol (PICO table)." /></a><div class="icnblk_cntnt"><h4 id="niceng154er18.tab1"><a href="/books/NBK555673/table/niceng154er18.tab1/?report=objectonly" target="object" rid-ob="figobniceng154er18tab1">Table 1</a></h4><p class="float-caption no_bottom_margin">Summary of the protocol (PICO table). </p></div></div><p>For full details see the review protocol in <a href="#niceng154er18.appa">appendix A</a>.</p></div><div id="niceng154er18.s1.1.3"><h4>Clinical evidence</h4><div id="niceng154er18.s1.1.3.1"><h5>Included studies</h5><p>No randomised controlled trials (RCTs) were identified; therefore, observational studies were included to inform decision making.</p><p>Four observational studies (Furtado 2015, <a class="bibr" href="#niceng154er18.s1.1.ref2" rid="niceng154er18.s1.1.ref2">Gover 2014</a>, <a class="bibr" href="#niceng154er18.s1.1.ref3" rid="niceng154er18.s1.1.ref3">Jeong 2016</a>, <a class="bibr" href="#niceng154er18.s1.1.ref4" rid="niceng154er18.s1.1.ref4">Sneve 2008</a>) were identified for this review.</p><p>One study (Furtado 2015) compared the outcomes of infants with intestinal failure who were managed by an MDT (professionals from gastroenterology, neonatology, general surgery, nursing, nutrition, pharmacy, social work, and occupational therapy) to infants from a historic cohort who had not been treated by an MDT.</p><p>One study (<a class="bibr" href="#niceng154er18.s1.1.ref2" rid="niceng154er18.s1.1.ref2">Gover 2014</a>) compared the outcomes of infants with gastroschisis who were managed by an MDT (professionals from three or more disciplines, e.g. neonatology, gastroenterology, dietetics)) to a control group of babies who had not been treated by an MDT</p><p>One study (<a class="bibr" href="#niceng154er18.s1.1.ref3" rid="niceng154er18.s1.1.ref3">Jeong 2016</a>) compared improvements in clinical and nutritional outcomes in preterm infants managed by a multidisciplinary nutritional support team to a historical cohort who had not received treatment from an MDT.</p><p>One study (<a class="bibr" href="#niceng154er18.s1.1.ref4" rid="niceng154er18.s1.1.ref4">Sneve 2008</a>) compared the outcomes of neonates ≤1500g who were managed by an MDT, which included a registered dietitian, to a historical cohort of babies managed before the introduction of the MDT.</p><p>It was not considered appropriate to pool the data from the Furtado 2015 and <a class="bibr" href="#niceng154er18.s1.1.ref2" rid="niceng154er18.s1.1.ref2">Gover 2014</a> studies with the <a class="bibr" href="#niceng154er18.s1.1.ref3" rid="niceng154er18.s1.1.ref3">Jeong 2016</a> and <a class="bibr" href="#niceng154er18.s1.1.ref4" rid="niceng154er18.s1.1.ref4">Sneve 2008</a> studies (which were considered similar inough to combine where outcomes align) due to the heterogeneous nature of the populations. The babies included in the Furtado 2015 and <a class="bibr" href="#niceng154er18.s1.1.ref2" rid="niceng154er18.s1.1.ref2">Gover 2014</a> studies had different complex needs and were therefore also not combined with each other; intestinal failure and gastroschisis respectively.</p><p>The included studies are summarised in <a class="figpopup" href="/books/NBK555673/table/niceng154er18.tab2/?report=objectonly" target="object" rid-figpopup="figniceng154er18tab2" rid-ob="figobniceng154er18tab2">Table 2</a>.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figniceng154er18tab2"><a href="/books/NBK555673/table/niceng154er18.tab2/?report=objectonly" target="object" title="Table 2" class="img_link icnblk_img figpopup" rid-figpopup="figniceng154er18tab2" rid-ob="figobniceng154er18tab2"><img class="small-thumb" src="/books/NBK555673/table/niceng154er18.tab2/?report=thumb" src-large="/books/NBK555673/table/niceng154er18.tab2/?report=previmg" alt="Table 2. Summary of included studies." /></a><div class="icnblk_cntnt"><h4 id="niceng154er18.tab2"><a href="/books/NBK555673/table/niceng154er18.tab2/?report=objectonly" target="object" rid-ob="figobniceng154er18tab2">Table 2</a></h4><p class="float-caption no_bottom_margin">Summary of included studies. </p></div></div><p>See the literature search strategy in <a href="#niceng154er18.appb">appendix B</a>, study selection flow chart in <a href="#niceng154er18.appc">appendix C</a>, study evidence tables in <a href="#niceng154er18.appd">appendix D</a>, forest plots in <a href="#niceng154er18.appe">appendix E</a>, and GRADE tables in <a href="#niceng154er18.appf">appendix F</a>.</p></div><div id="niceng154er18.s1.1.3.2"><h5>Excluded studies</h5><p>Studies not included in this review are listed, and reasons for their exclusions are provided in <a href="#niceng154er18.appk">appendix K</a>.</p></div></div><div id="niceng154er18.s1.1.4"><h4>Summary of clinical studies included in the evidence review</h4><p>Summaries of the studies that were included in this review are presented <a class="figpopup" href="/books/NBK555673/table/niceng154er18.tab2/?report=objectonly" target="object" rid-figpopup="figniceng154er18tab2" rid-ob="figobniceng154er18tab2">Table 2</a></p><p>See <a href="#niceng154er18.appd">appendix D</a> for the full evidence tables.</p></div><div id="niceng154er18.s1.1.5"><h4>Quality assessment of clinical outcomes included in the evidence review</h4><p>GRADE was conducted to assess the quality of outcomes. Evidence was identified for critical and important outcomes. The clinical evidence profiles can be found in <a href="#niceng154er18.appf">appendix F</a>.</p></div><div id="niceng154er18.s1.1.6"><h4>Economic evidence</h4><div id="niceng154er18.s1.1.6.1"><h5>Included studies</h5><p>A systematic review of the economic literature was conducted but no economic studies were identified which were applicable to this review question. A single economic search was undertaken for all topics included in the scope of this guideline. Please see <a href="/books/NBK555673/bin/niceng154er18_bm4.pdf">supplementary material D</a> for details.</p></div><div id="niceng154er18.s1.1.6.2"><h5>Excluded studies</h5><p>Studies not included in this review are listed, and reasons for their exclusions are provided in <a href="#niceng154er18.appk">appendix K</a>.</p></div></div><div id="niceng154er18.s1.1.7"><h4>Summary of studies included in the economic evidence review</h4><p>No economic evaluations were identified which were applicable to this review question.</p></div><div id="niceng154er18.s1.1.8"><h4>Economic model</h4><p>This topic was identified as a priority for economic modelling. However, the clinical evidence was of poor quality and insufficient to inform an economic model that would be useful for decision making in this area.</p></div><div id="niceng154er18.s1.1.9"><h4>Clinical evidence statements</h4><div id="niceng154er18.s1.1.9.1"><h5>Weight z-score (discharge)</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=229) showed no clinically important difference in weight at discharge of non-complex babies who received support from a nutrition support team as compared to those who did not have a nutrition support team; Mean difference (MD): 0.16 (95% CI −0.01 to 0.42).</div></li></ul></div><div id="niceng154er18.s1.1.9.2"><h5>Weight at discharge</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=105) showed a clinically important difference in weight at discharge of non-complex babies who received support from a nutrition support team as compared to those who did not have a nutrition support team; with an MDT resulting in greater weight: MD 503g (95% CI 327.23 to 678.77).</div></li></ul></div><div id="niceng154er18.s1.1.9.3"><h5>Weight change z-score (during hospital stay)</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=229) showed no clinically important difference in the weight change during hospital stay of non-complex babies who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team; MD 0.22 (95% CI −0.01 to 0.45).</div></li></ul></div><div id="niceng154er18.s1.1.9.4"><h5>Weight gained</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=105) showed a clinically important difference in the weight gained between non-complex babies who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team, an MDT resulted in greater weight gain. However, there was uncertainty around the effect: MD 358g (95% CI 212.27 to 743.73).</div></li></ul></div><div id="niceng154er18.s1.1.9.5"><h5>Head circumference growth</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=105) showed a clinically important difference in the growth of non-complex babies head circumference between those who received support from a nutrition/care support team as compared to those who did not, the MDT resulted in better growth. However, there was uncertainty around the effect: MD 2cm (95% CI 0.91 to 3.09).</div></li></ul></div><div id="niceng154er18.s1.1.9.6"><h5>Head circumference at discharge</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=105) showed a clinically important difference in the total head circumference between non-complex babies who received support from a nutrition/care support team as compared to those who did, an MDT resulted in greater head circumference at discharge: MD 2cm (95% CI 1.46 to 2.54).</div></li></ul></div><div id="niceng154er18.s1.1.9.7"><h5>Total length growth</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=105) showed no clinically important difference in the length of non-complex babies between those who received support from a nutrition/care support team as compared to those who did not; MD 1cm (95% CI −1.08 to 3.08).</div></li></ul></div><div id="niceng154er18.s1.1.9.8"><h5>Length at discharge</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=105) showed a clinically important difference in the length of non-complex babies at discharge between those who received support from a nutrition/care support team as compared to those who did not, an MDT resulted in greater length of babies at discharge. However, there was uncertainty around the effect; MD 2cm (95% CI 0.77 to 3.23).</div></li></ul></div><div id="niceng154er18.s1.1.9.9"><h5>Length of stay in NICU</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=55) showed no clinically important difference in the mean number of days spent in NICU of babies with intestinal failure who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team. However, there was uncertainty around the effect; MD −10.00 (95% CI −49.73 to 29.73).</div></li><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=396) showed no clinically important difference in the mean number of days spent in NICU of babies with gastroschisis who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team; MD 13.00 (95% CI 2.34 to 23.66).</div></li><li class="half_rhythm"><div>Very low quality evidence from 2 observational studies (n=334 ) showed no clinically important difference in the mean number of days spent in NICU of non-complex babies who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team. However, there was uncertainty around the effect; MD −1.57 days (95% CI −17.74 to 14.60).</div></li></ul></div><div id="niceng154er18.s1.1.9.10"><h5>Achievement of 80kcal/kg on day 7</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=229) showed a clinically important difference in the number of non-complex babies who achieved 80kcal/kg on day 7 in those who received support from a nutrition support team as compared to those who did not have a nutrition support team, with more babies cared for by an MDT achieving this target. However, there was uncertainty around the effect: Relative risk (RR) 1.5 (95% CI 1.16 to 1.95).</div></li></ul></div><div id="niceng154er18.s1.1.9.11"><h5>PN duration</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=55) showed a clinically important difference in the duration that babies with intestinal failure were on PN between those who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team, those babies cared for by an MDT were on PN for a longer duration. However, there was uncertainty around the effect: MD 63.70 (95%CI 20.34 to 107.06).</div></li><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=396) showed no clinically important difference in the duration that babies with gastroschisis were on PN between babies who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team. However, there was uncertainty around the effect; MD 13.00 (95%CI 4.59 to 21.41).</div></li><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=229) showed no clinically important difference in duration of PN between non-complex babies who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team; MD −4.4 (95%CI −9.31 to 0.51)</div></li></ul></div><div id="niceng154er18.s1.1.9.12"><h5>Mortality</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=55) showed a clinically important difference in mortality of babies with intestinal failure who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team, fewer occurrences of mortality were observed in those babies cared for by an MDT. However, there was high uncertainty around the effect: RR 0.48 (95% CI 0.10 to 2.42).</div></li><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=396) showed a clinically important difference in mortality of babies with gastroschisis who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team, fewer occurrences of mortality were observed in those babies cared for by an MDT. However, there was high uncertainty around the effect: RR 0.47 (95% CI 0.16 to 1.35).</div></li><li class="half_rhythm"><div>Very low quality evidence from 2 observational studies (n=334) showed a clinically important difference in mortality of non-complex babies who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team, greater occurrences of mortality were observed with an MDT. However, there was high uncertainty around the effect: RR 1.94 (95%CI 0.47 to 8.09).</div></li></ul></div><div id="niceng154er18.s1.1.9.13"><h5>Necrotising enterocolitis (NEC)</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 2 observational studies (n=334) showed no clinically important difference in the number of non-complex babies with NEC between those who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team. However, there was high uncertainty around the effect; RR 1.20 (95% CI 0.53 to 2.72).</div></li></ul></div><div id="niceng154er18.s1.1.9.14"><h5>Sepsis</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=229) showed no clinically important difference in the number of non-complex babies with sepsis between those who received support from a nutrition/care support team as compared to those who did not have a nutrition support/care team. However, there was high uncertainty around the effect; RR 1.21 (95%CI 0.79 to 1.87).</div></li><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=55) showed a clinically-important difference in the occurrence of sepsis in babies with intestinal failure, with greater occurrences in babies who received support from a nutrition/care support team as compared to those who did not have a nutrition/care support team. However, there was uncertainty around the effect; RR 1.29 (95%CI 0.95 to 1.75).</div></li></ul></div><div id="niceng154er18.s1.1.9.15"><h5>Mean number of septic episodes per baby</h5><ul><li class="half_rhythm"><div>Very low quality evidence from 1 observational study (n=55) showed no clinically important difference in the number of septic episodes in babies with intestinal failure who received support from a nutrition/care support team as compared to those who did have a nutrition/care support team. However, there was high uncertainty around the effect, MD 0.00 (95%CI −1.35 to 1.35).</div></li></ul></div></div><div id="niceng154er18.s1.1.10"><h4>Economic evidence statements</h4><p>No studies were identified which were applicable to this review question.</p></div><div id="niceng154er18.s1.1.11"><h4>The committee’s discussion of the evidence</h4><div id="niceng154er18.s1.1.11.1"><h5>Interpreting the evidence</h5><div id="niceng154er18.s1.1.11.1.1"><h5>The outcomes that matter most</h5><p>The committee agreed that anthropometric outcomes, prescribing errors and achievement of target intake were the critical outcomes for this review. These outcomes are potentially influenced by the makeup of the team members who determine PN, for instance good oversight from a pharmacist with expertise should reduce prescribing errors. Important outcomes included alteration to PN provision, adherence to monitoring, duration of PN, adverse events, duration of hospital stay and parental satisfaction. These outcomes may all be influenced by an MDT, but would also be influenced by other factors within the NICU (for instance duration of PN may be due to the gestational age of the baby rather than due to the constituency of the MDT).</p></div><div id="niceng154er18.s1.1.11.1.2"><h5>The quality of the evidence</h5><p>The included outcomes were assessed using GRADE methodology, and all evidence presented was considered very low quality, indicating the data is unreliable. The included studies were all retrospective in design, and were downgraded due to serious risk of bias from confounding, deviations from the intended interventions, and unclear bias in measurement of outcomes. There was a high level of heterogeneity in the studies, and as such not all studies were combined (where populations varied considerably), analysis using a random effects model was undertaken to take this heterogeneity into account. In addition, data was considered imprecise; in sum the evidence should be interpreted with caution. None of the studies were from the UK, which also makes the services less generalisable to an NHS setting.</p></div><div id="niceng154er18.s1.1.11.1.3"><h5>Benefits and harms</h5><p>The committee agreed that overall the evidence was very low quality; however the evidence supported their knowledge and experience of when an MDT is likely more effective, for example babies with complex needs. Therefore, the committee considered the evidence and used it to support their clinical experience to make the recommendations by informal consensus.</p><p>Overall the evidence demonstrated that babies had a greater weight gain, greater weight at discharge and greater increase in head circumference when cared for by an MDT. However, some of the data (for example weight z-score at discharge and weight z-score during hospital stay and total length at discharge) showed no difference between groups in these outcomes, and this may be due to high levels of imprecision, making it difficult to draw firm conclusions.</p><p>In general, the included studies did not describe the composition of the non-MDT arm, so it was difficult to determine what effect the newly introduced MDT may be having on overall care. One study showed a significantly greater number of babies who were cared for by an MDT achieved a specific target of intake (80kcal/kg on day 7 [<a class="bibr" href="#niceng154er18.s1.1.ref3" rid="niceng154er18.s1.1.ref3">Jeong 2016</a>]), and another study showed clinical benefits in weight and head circumference for babies who were cared for by an MDT [<a class="bibr" href="#niceng154er18.s1.1.ref4" rid="niceng154er18.s1.1.ref4">Sneve 2008</a>]).</p><p>Two of the included studies (<a class="bibr" href="#niceng154er18.s1.1.ref1" rid="niceng154er18.s1.1.ref1">Furtado 2016</a> and <a class="bibr" href="#niceng154er18.s1.1.ref2" rid="niceng154er18.s1.1.ref2">Gover 2014</a>) included babies with short gut syndrome and intestinal failure respectively; these are not the most frequent indications for PN in neonates, and only account for a small number of babies receiving PN; therefore, these studies were considered in isolation. The studies showed that fewer of these babies died when an MDT provided care. The presence of the MDT also resulted in babies receiving PN for longer. The committee discussed how it is difficult to determine whether it is more beneficial or not for babies to be on PN for longer or shorter time-periods; if a baby stays on PN for longer they may be receiving better nutrition, but they are at risk of line infections; however, the data did not clearly show this; therefore, the longer duration of PN did not appear to be detrimental. The committee agreed that with complex babies more regular MDT team meetings are likely required, and a wider range of specialist should be included (for example a gastroenterologist, who may not normally be included in the MDT).</p><p>The committee agreed that the included evidence, despite the limitations discussed above, demonstrated some benefits related to the clinical MDT. They noted that the evidence did not allow them to exactly determine which health care professionals should make up the MDT, and they agreed that details of the daily work of the MDT could not be defined because that would depend on the case load and the type of babies that are seen in the services that they would oversee or support. Even though the evidence did not directly address this, based on their knowledge of current practice and national reports related to shortcomings of current PN provision (see other considerations below) the committee also recognised that the team should not only provide clinical input but should also provide oversight of services. The committee agreed that policies and protocols are needed as well as the auditing of outcomes to ensure the safety of PN provision. The committee decided that a team of specialists should be accessible to all services providing PN. Such teams should always contain a consultant neonatologist or paediatrician with a special interest in nutrition, pharmacist and dietitian to ensure there is expertise in the clinical, prescribing and nutritional core components of neonatal PN. The committee also recognised that access to other roles may be required, such as neonatal nursing, paediatric gastroenterology or expertise in clinical biochemistry to cover specific clinical or specialist areas of PN. The committee noted that if all core professionals listed in the recommendation and access to additional expertise where needed, to provide governance or clinical support, this would likely result in the provision of optimum PN for neonates. The committee are aware that not all units have all the listed professionals present on their units all the time. They discussed that most babies would not require daily bed-side assessments by all members listed within the MDT but that services need to be set up so that an MDT would have oversight of PN provision. This could mean access to them within a clinical network rather than availability to all of them locally.</p><p>The committee agreed that it is important that all members of the MDT have responsibility for PN governance and supporting delivery of PN. The committee discussed the importance of these professionals having their role within the MDT clearly recognised, and each member of the team would have clear and specific roles and responsibilities defined; however, they agreed this would be aspirational, but hope that these recommendations result in MDT members having dedicated time allocated for them to fulfil this role.</p><p>The committee, based on the evidence which demonstrated better outcomes associated with MDT involvement for babies with short gut syndrome or intestinal failure, agreed by informal consensus that babies with complex needs may require input from professionals other than those they listed for the oversight team. This ‘enhanced’ team could require the expertise of a gastroenterologist or a surgeon but the committee did not want to be prescriptive about these additional specialists. They agreed that the composition of an enhanced team would need to be tailored to each individual baby.</p></div></div><div id="niceng154er18.s1.1.11.2"><h5>Cost effectiveness and resource use</h5><p>No economic studies were identified which were applicable to this review question.</p><p>The committee explained that the question is not whether MDT should be provided or not. MDT input is necessary and the real question is as to the best composition and structure of the MDT. The committee noted that the clinical evidence was poor and insufficient to guide the committee as to the best composition of MDT and how the expertise of the team is used in service provision.</p><p>The committee discussed the role of the MDT i.e. to oversee and support the service to ensure that clinicians involved in the day to day care of the baby adhere to the guidelines and standards. They would also give a steer in the management of complicated cases. The committee also discussed key individuals required for this oversight MDT including consultant paediatrician or neonatologist, pharmacist, dietitian, neonatal nurse, and in some complicated cases a paediatric gastroenterologist. The committee noted that there may be a lack of certain experts in some centres and that there may be procurement issues. The committee explained that the network or regional centres should have such expertise available and individual centres within a network can draw on this expertise to support their local needs. The committee highlighted that these professionals already exist within the NHS and are funded for being part of the paediatric team and so the recommendations in this area would not incur additional resources to the NHS.</p><p>The committee explained that the MDT input would increase with the severity of the baby’s condition. However, this is standard clinical practice and the recommendation pertaining to the enhanced MDT would not incur additional resources to the NHS.</p></div><div id="niceng154er18.s1.1.11.3"><h5>Other factors the committee took into account</h5><p>The committee took into account national reports that highlight inadequacies and safety concerns in the provision of neonatal PN (such as the National Confidential Enquiry into Patient Outcome and Death – <a href="https://www.ncepod.org.uk/2010pn.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PN</a> from 2010 and the report from the Paediatric Chief Pharmacists Group in 2011 - <a href="https://www.rpharms.com/Portals/0/RPS%20document%20library/Open%20access/Hospital%20Pharmacy%20Hub/minimising-risk-pn-children-%286%29.pdf" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">improving practice and reducing risk in the provision of PN for neonates and children</a>). They agreed that strong recommendations in favour of MDT input would help to address the concerns raised in these reports.</p></div></div><div id="niceng154er18.rl.r1"><h4>References</h4><ul class="simple-list"><li class="half_rhythm"><p><div class="bk_ref" id="niceng154er18.s1.1.ref1"><p id="p-165">
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<strong>Furtado 2016</strong>
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</p>Furtado
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S., Ahmed
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N., Forget
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S., Sant’ Anna
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A., Outcomes of patients with intestinal failure after the development and implementation of a multidisciplinary team. Canadian Journal of Gastroenterology and Hepatology, ID 9132134, 2016. [<a href="/pmc/articles/PMC4904660/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4904660</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27446876" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27446876</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="niceng154er18.s1.1.ref2"><p id="p-166">
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<strong>Gover 2014</strong>
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</p>Gover
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A., Albersheim
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S., Sherlock
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R., Claydon
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J., Butterworth
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S., Kuzeljevic
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B., Outcome of patients with gastroschisis managed with and without multidisciplinary teams in Canada. Paediatric Child Health
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19 (3), 128–132, 2014. [<a href="/pmc/articles/PMC3959971/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3959971</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24665222" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24665222</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="niceng154er18.s1.1.ref3"><p id="p-167">
|
|
<strong>Jeong 2016</strong>
|
|
</p>Jeong
|
|
E., Jung
|
|
YH., Shin
|
|
SH., Kim
|
|
MJ., Bae
|
|
HJ., Cho
|
|
YS., Kim
|
|
KS., Kim
|
|
HS., Moon
|
|
JS., Kim
|
|
e-K., Kim
|
|
H-S., Ko
|
|
JS., The successful accomplishment of nutritional and clinical outcomes via the implementation of a multidisciplinary nutrition support team in the neonatal intensive care unit. BMC Paediatrics
|
|
16: 113, 2016. [<a href="/pmc/articles/PMC4963950/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4963950</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27465214" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27465214</span></a>]</div></p></li><li class="half_rhythm"><p><div class="bk_ref" id="niceng154er18.s1.1.ref4"><p id="p-168">
|
|
<strong>Sneve 2008</strong>
|
|
</p>Sneve
|
|
J., Kattelmann
|
|
K., Ren
|
|
C., Stevens
|
|
DC., Implementation of a Multidisciplinary team that includes a registered dietitian in a neonatal intensive care unit improved nutrition outcomes. Nutrition in Clinical Practice
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23 (6), 630–634, 2008. [<a href="https://pubmed.ncbi.nlm.nih.gov/19033222" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19033222</span></a>]</div></p></li></ul></div></div></div><div id="appendixesappgroup1"><h2 id="_appendixesappgroup1_">Appendices</h2><div id="niceng154er18.appa"><h3>Appendix A. Review protocols</h3><div id="niceng154er18.appa.s1"><h4>Review protocol for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p id="niceng154er18.appa.tab1"><a href="/books/NBK555673/table/niceng154er18.appa.tab1/?report=objectonly" target="object" rid-ob="figobniceng154er18appatab1" class="figpopup">Table 3. Review protocol for review question: Are nutrition care/support teams effective in providing PN in preterm and term babies?</a></p></div></div><div id="niceng154er18.appb"><h3>Appendix B. Literature search strategies</h3><div id="niceng154er18.appb.s1"><h4>Literature search strategy for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p id="niceng154er18.appb.tab1"><a href="/books/NBK555673/table/niceng154er18.appb.tab1/?report=objectonly" target="object" rid-ob="figobniceng154er18appbtab1" class="figpopup">Databases: Medline; Medline EPub Ahead of Print; and Medline In-Process & Other Non-Indexed Citations</a></p><p id="niceng154er18.appb.tab2"><a href="/books/NBK555673/table/niceng154er18.appb.tab2/?report=objectonly" target="object" rid-ob="figobniceng154er18appbtab2" class="figpopup">Databases: Embase; and Embase Classic</a></p><p id="niceng154er18.appb.tab3"><a href="/books/NBK555673/table/niceng154er18.appb.tab3/?report=objectonly" target="object" rid-ob="figobniceng154er18appbtab3" class="figpopup">Databases: Cochrane Central Register of Controlled Trials; Cochrane Database of Systematic Reviews; Database of Abstracts of Reviews of Effects; and Health Technology Assessment</a></p></div></div><div id="niceng154er18.appc"><h3>Appendix C. Clinical evidence study selection</h3><div id="niceng154er18.appc.s1"><h4>Clinical study selection for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p id="niceng154er18.appc.fig1"><a href="/books/NBK555673/figure/niceng154er18.appc.fig1/?report=objectonly" target="object" rid-ob="figobniceng154er18appcfig1" class="figpopup">Figure 1. PRISMA Flow chart of clinical article selection for review question: Are nutrition care/support teams effective in providing PN in preterm and term babies?</a></p></div></div><div id="niceng154er18.appd"><h3>Appendix D. Clinical evidence tables</h3><div id="niceng154er18.appd.s1"><h4>Clinical evidence tables for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p id="niceng154er18.appd.et1"><a href="/books/NBK555673/bin/niceng154er18-appd-et1.pdf" class="bk_dwnld_icn bk_dwnld_pdf">Table 4. Clinical evidence tables for included studies</a><span class="small"> (PDF, 665K)</span></p></div></div><div id="niceng154er18.appe"><h3>Appendix E. Forest plots</h3><div id="niceng154er18.appe.s1"><h4>Forest plots for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p id="niceng154er18.appe.fig1"><a href="/books/NBK555673/figure/niceng154er18.appe.fig1/?report=objectonly" target="object" rid-ob="figobniceng154er18appefig1" class="figpopup">Figure 2. MDT versus no MDT; length of stay in NICU</a></p><p id="niceng154er18.appe.fig2"><a href="/books/NBK555673/figure/niceng154er18.appe.fig2/?report=objectonly" target="object" rid-ob="figobniceng154er18appefig2" class="figpopup">Figure 3. MDT versus no MDT; mortality of babies</a></p><p id="niceng154er18.appe.fig3"><a href="/books/NBK555673/figure/niceng154er18.appe.fig3/?report=objectonly" target="object" rid-ob="figobniceng154er18appefig3" class="figpopup">Figure 4. MDT versus no MDT; Necrotising enterocolitis</a></p></div></div><div id="niceng154er18.appf"><h3>Appendix F. GRADE tables</h3><div id="niceng154er18.appf.s1"><h4>GRADE tables for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p id="niceng154er18.appf.tab1"><a href="/books/NBK555673/table/niceng154er18.appf.tab1/?report=objectonly" target="object" rid-ob="figobniceng154er18appftab1" class="figpopup">Table 5. Clinical evidence profile for MDT versus no MDT</a></p></div></div><div id="niceng154er18.appg"><h3>Appendix G. Economic evidence study selection</h3><div id="niceng154er18.appg.s1"><h4>Economic evidence study selection for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p>One global search was conducted for all review questions. See <a href="/books/NBK555673/bin/niceng154er18_bm4.pdf">supplementary material D</a> for further information.</p></div></div><div id="niceng154er18.apph"><h3>Appendix H. Economic evidence tables</h3><div id="niceng154er18.apph.s1"><h4>Economic evidence tables for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p>No evidence was identified which was applicable to this review question.</p></div></div><div id="niceng154er18.appi"><h3>Appendix I. Economic evidence profiles</h3><div id="niceng154er18.appi.s1"><h4>Economic evidence profiles for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p>No economic studies were identified which were applicable to this review question.</p></div></div><div id="niceng154er18.appj"><h3>Appendix J. Economic analysis</h3><div id="niceng154er18.appj.s1"><h4>Economic analysis for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p>No economic analysis was undertaken for this review question.</p></div></div><div id="niceng154er18.appk"><h3>Appendix K. Excluded studies</h3><div id="niceng154er18.appk.s1"><h4>Excluded studies for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><div id="niceng154er18.appk.s1.1"><h5>Clinical studies</h5><p id="niceng154er18.appk.tab1"><a href="/books/NBK555673/table/niceng154er18.appk.tab1/?report=objectonly" target="object" rid-ob="figobniceng154er18appktab1" class="figpopup">Table 6. Excluded studies and reasons for their exclusion</a></p></div><div id="niceng154er18.appk.s1.2"><h5>Economic studies</h5><p>No economic evidence was identified for this review question. See <a href="/books/NBK555673/bin/niceng154er18_bm4.pdf">supplementary material D</a> for further information.</p></div></div></div><div id="niceng154er18.appl"><h3>Appendix L. Research recommendations</h3><div id="niceng154er18.appl.s1"><h4>Research recommendations for review question: Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</h4><p>No research recommendations were made for this review question.</p></div></div></div></div><div class="fm-sec"><div><p>Final</p></div><div><p>Evidence reviews</p><p>These evidence reviews were developed by the National Guideline Alliance which is part of the Royal College of Obstetricians and Gynaecologists</p></div><div><p><b>Disclaimer</b>: The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The recommendations in this guideline are not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.</p><p>Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.</p><p>NICE guidelines cover health and care in England. Decisions on how they apply in other UK countries are made by ministers in the <a href="http://wales.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Welsh Government</a>, <a href="http://www.scotland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Scottish Government</a>, and <a href="http://www.northernireland.gov.uk/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Northern Ireland Executive</a>. All NICE guidance is subject to regular review and may be updated or withdrawn.</p></div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © NICE 2020.</div><div class="small"><span class="label">Bookshelf ID: NBK555673</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/32282155" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">32282155</a></span></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article><article data-type="table-wrap" id="figobniceng154er18tab1"><div id="niceng154er18.tab1" class="table"><h3><span class="label">Table 1</span><span class="title">Summary of the protocol (PICO table)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK555673/table/niceng154er18.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__niceng154er18.tab1_lrgtbl__"><table class="no_bottom_margin"><tbody><tr><th id="hd_b_niceng154er18.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population</th><td headers="hd_b_niceng154er18.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul><li class="half_rhythm"><div>Nutrition care/support teams providing PN to babies born preterm, up to 28 days after their due birth date (preterm babies)</div></li><li class="half_rhythm"><div>Nutrition care/support teams providing PN to babies born at term, up to 28 days after their birth (term babies)</div></li></ul></td></tr><tr><th id="hd_b_niceng154er18.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention</th><td headers="hd_b_niceng154er18.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Multidisciplinary team with a specified composition or working arrangements, for example, in relation to inclusion of a pharmacist, dietitian, neonatologist, neonatal nurse or biochemist (or other laboratory specialist).</td></tr><tr><th id="hd_b_niceng154er18.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Comparison</th><td headers="hd_b_niceng154er18.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul><li class="half_rhythm"><div>No nutrition care team</div></li><li class="half_rhythm"><div>An individual (for example, physician alone)</div></li><li class="half_rhythm"><div>A team with a different composition, or different arrangements for working together as compared to the intervention team.</div></li></ul></td></tr><tr><th id="hd_b_niceng154er18.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes</th><td headers="hd_b_niceng154er18.tab1_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Critical</b>
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<ul><li class="half_rhythm"><div>Growth/anthropometric measures</div></li><li class="half_rhythm"><div>Weight gain (g/kg/day)</div></li><li class="half_rhythm"><div>Linear growth (cm)</div></li><li class="half_rhythm"><div>Head circumference (cm)</div></li><li class="half_rhythm"><div>Weight for length</div></li><li class="half_rhythm"><div>Weight z score for age</div></li><li class="half_rhythm"><div>Prescribing error</div></li><li class="half_rhythm"><div>Achievement of target intake</div></li></ul>
|
|
<b>Important</b>
|
|
<ul><li class="half_rhythm"><div>Alteration to PN provision</div></li><li class="half_rhythm"><div>Adherence to monitoring</div></li><li class="half_rhythm"><div>Duration of PN</div></li><li class="half_rhythm"><div>Adverse events (such as infection [including sepsis], mortality)</div></li><li class="half_rhythm"><div>Duration of hospital stay</div></li><li class="half_rhythm"><div>Parental satisfaction (measured by a validated scale)</div></li></ul></td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">PN: Parenteral nutrition</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobniceng154er18tab2"><div id="niceng154er18.tab2" class="table"><h3><span class="label">Table 2</span><span class="title">Summary of included studies</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK555673/table/niceng154er18.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__niceng154er18.tab2_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_niceng154er18.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Study</th><th id="hd_h_niceng154er18.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Population</th><th id="hd_h_niceng154er18.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Intervention</th><th id="hd_h_niceng154er18.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Comparison</th><th id="hd_h_niceng154er18.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Outcomes</th><th id="hd_h_niceng154er18.tab2_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Comments</th></tr></thead><tbody><tr><td headers="hd_h_niceng154er18.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><a class="bibr" href="#niceng154er18.s1.1.ref1" rid="niceng154er18.s1.1.ref1">Furtado 2016</a></p>
|
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<p>Observational study</p>
|
|
<p>Canada</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>N= 55</p>
|
|
<p><u>Mean GA</u></p>
|
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<p>INFANT: 31.1 weeks (SD 4.8)</p>
|
|
<p>Pre-INFANT: 30.1 weeks (SD 4.9)</p>
|
|
<p><u>Mean BW</u></p>
|
|
<p>INFANT: 1736.8g (SD 975)</p>
|
|
<p>Pre-INFANT: 1473g (SD 920)</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><u>INFANT</u> (n=28)</p>
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<p>Included professionals from: gastroenterology, neonatology, general surgery, nursing, nutrition, pharmacy, social work, and occupational therapy</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><u>Pre-INFANT</u> (n= 27)</p>
|
|
<p>A historic cohort, prior to the MDT were introduced. No details on who provided care.</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<ul><li class="half_rhythm"><div>Duration of TPN</div></li><li class="half_rhythm"><div>At least 1 septic episode</div></li><li class="half_rhythm"><div>Septic episodes per patient</div></li><li class="half_rhythm"><div>Mortality</div></li><li class="half_rhythm"><div>Duration of hospital stay</div></li></ul></td><td headers="hd_h_niceng154er18.tab2_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Babies all had short bowel syndrome (defined as the need for PN for more than 42 days after bowel resection or a residual small bowel length of less than 25% expected for GA).</td></tr><tr><td headers="hd_h_niceng154er18.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><a class="bibr" href="#niceng154er18.s1.1.ref2" rid="niceng154er18.s1.1.ref2">Gover, 2014</a></p>
|
|
<p>Observational study</p>
|
|
<p>Canada</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>N = 396</p>
|
|
<p><u>Mean GA</u></p>
|
|
<p>MDT: 36<sup>+2</sup> weeks (SD 2)</p>
|
|
<p>Control: 36<sup>+2</sup> weeks (SD 2)</p>
|
|
<p><u>Mean BW</u></p>
|
|
<p>MDT: 2552g (SD 547)</p>
|
|
<p>Control: 2551g (SD 560)</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><u>MDT</u></p>
|
|
<p>(7 centres, n= 204)</p>
|
|
<p>Included professionals from:</p>
|
|
<p>3 or more disciplines (e.g. neonatology, surgery, gastroenterology, dietetics)</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><u>Control</u></p>
|
|
<p>(9 centres, n=192)</p>
|
|
<p>Centres had no MDT</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul><li class="half_rhythm"><div>Duration of PN</div></li><li class="half_rhythm"><div>Length of stay</div></li><li class="half_rhythm"><div>Mortality</div></li><li class="half_rhythm"><div>At least one infection</div></li></ul></td><td headers="hd_h_niceng154er18.tab2_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Babies with gastroschisis</td></tr><tr><td headers="hd_h_niceng154er18.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><a class="bibr" href="#niceng154er18.s1.1.ref3" rid="niceng154er18.s1.1.ref3">Jeong, 2016</a></p>
|
|
<p>Observational study</p>
|
|
<p>South Korea</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>N = 229</p>
|
|
<p><u>Mean GA</u></p>
|
|
<p>NST: 28<sup>+1</sup> weeks (SD 2)</p>
|
|
<p>Pre-NST: 27<sup>+5</sup> weeks (SD 2)</p>
|
|
<p><u>Mean BW</u></p>
|
|
<p>NST: 952g (SD 266)</p>
|
|
<p>Pre-NST: 895g (SD 260)</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><u>Nutritional Support Team</u> (NST) (n= 122)</p>
|
|
<p>Nutritional support through enhanced co-ordination of specialists (pharmacists, dietitians and nurses)</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><u>Pre-NST:</u> (n= 107)</p>
|
|
<p>Support co-ordinated solely by the attending physician, with intermittent consultation with pharmacists.</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<ul><li class="half_rhythm"><div>Weight Z-score (at discharge)</div></li><li class="half_rhythm"><div>Weight change Z-score (during hospital stay)</div></li><li class="half_rhythm"><div>Achievement of 80kcal/kg at day 7</div></li><li class="half_rhythm"><div>PN Duration</div></li><li class="half_rhythm"><div>Length of ICU stay</div></li><li class="half_rhythm"><div>Mortality</div></li><li class="half_rhythm"><div>Sepsis</div></li><li class="half_rhythm"><div>NEC</div></li></ul></td><td headers="hd_h_niceng154er18.tab2_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Babies were less than 30 weeks’ GA and had BW less than 1250g</td></tr><tr><td headers="hd_h_niceng154er18.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><a class="bibr" href="#niceng154er18.s1.1.ref4" rid="niceng154er18.s1.1.ref4">Sneve 2008</a></p>
|
|
<p>Observational study</p>
|
|
<p>USA</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>N = 105</p>
|
|
<p><u>Mean BW</u></p>
|
|
<p>MDT: 1164g (95% CI 1067 – 1217)</p>
|
|
<p>Pre-team: 1099g (95% CI 1003 – 1197)</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><u>MDT</u> (n=63)</p>
|
|
<p>Included a registered dietitian plus a neonatologist, clinical care co-ordinator, health unit co-ordinator, respiratory therapist, social worker, paediatric pharmacist, nursing director, nurses, case manager, nurse practitioner, medial consultants, paediatric development specialist and chaplain.</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p><u>Pre-team</u> (n=42)</p>
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<p>A historical cohort of babies prior to the MDT. No details as to who provided care</p></td><td headers="hd_h_niceng154er18.tab2_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul><li class="half_rhythm"><div>Weight</div></li><li class="half_rhythm"><div>Head circumference</div></li><li class="half_rhythm"><div>Length</div></li><li class="half_rhythm"><div>NEC</div></li><li class="half_rhythm"><div>Mortality</div></li><li class="half_rhythm"><div>Length of stay</div></li></ul></td><td headers="hd_h_niceng154er18.tab2_1_1_1_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">No gestation of babies was provided. All babies weighed less than, or equal to 1500g</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">BW: Birth weight; CI: confidence interval; GA: gestational age; ICU: intensive care unit; INFANT: Intestinal Failure and Advanced Nutrition Team; MDT: Multidisciplinary team; NEC: necrotising enterocolitis; NST: Nutrition support team; VLBW: Very low birth weight; PN: Parenteral nutrition; SD Standard deviation.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobniceng154er18appatab1"><div id="niceng154er18.appa.tab1" class="table"><h3><span class="label">Table 3</span><span class="title">Review protocol for review question: Are nutrition care/support teams effective in providing PN in preterm and term babies?</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK555673/table/niceng154er18.appa.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__niceng154er18.appa.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Field (based on <a href="http://www.prisma-statement.org/Extensions/Protocols.aspx" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PRISMA-P</a></th><th id="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Content</th></tr></thead><tbody><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Review question</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Are nutrition care/support teams effective in providing parenteral nutrition in preterm and term babies?</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Type of review question</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Intervention</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Objective of the review</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Due to the complexity of providing parenteral nutrition (PN) to babies, multidisciplinary care teams are recommended. Determining whether multidisciplinary teams, decrease the risk of PN related complications is required. The aim of this review is to determine if nutrition care teams are effective and safe in providing parenteral nutrition in preterm and term babies.</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – population/disease/condition/issue/domain</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul><li class="half_rhythm"><div>Nutrition care teams providing PN to babies born preterm, up to 28 days after their due birth date (preterm babies)</div></li><li class="half_rhythm"><div>Nutrition care teams providing PN to babies born at term, up to 28 days after their birth (term babies).</div></li></ul></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – intervention(s)/exposure(s)/prognostic factor(s)</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Multidisciplinary team with a specified composition or working arrangements, for example in relation to inclusion of a pharmacist, dietitian, neonatologist, neonatal nurse or biochemist (or other lab specialist).</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – comparator(s)/control or reference (gold) standard</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<ul><li class="half_rhythm"><div>No nutrition care team</div></li><li class="half_rhythm"><div>An individual (for example, physician alone)</div></li><li class="half_rhythm"><div>A team with a different composition, or different arrangements for working together as compared to the intervention team</div></li></ul></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outcomes and prioritisation</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><b>Critical</b>
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<ul><li class="half_rhythm"><div>Growth/anthropometric measures
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<ul class="circle"><li class="half_rhythm"><div>Weight gain (g/kg/day)</div></li><li class="half_rhythm"><div>Linear growth (cm)</div></li><li class="half_rhythm"><div>Head circumference (cm)</div></li><li class="half_rhythm"><div>Weight for length</div></li><li class="half_rhythm"><div>Weight z score for age</div></li><li class="half_rhythm"><div>2<sup>nd</sup> percentile of body mass index</div></li></ul></div></li><li class="half_rhythm"><div>Prescribing error</div></li><li class="half_rhythm"><div>Achievement of target intake</div></li></ul>
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<b>Important</b>
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<ul><li class="half_rhythm"><div>Alteration to PN provision</div></li><li class="half_rhythm"><div>Adherence to monitoring</div></li><li class="half_rhythm"><div>Duration of PN</div></li><li class="half_rhythm"><div>Adverse events (such as infection (including sepsis), mortality)</div></li><li class="half_rhythm"><div>Duration of hospital stay</div></li><li class="half_rhythm"><div>Parental satisfaction (measured by a validated scale)</div></li></ul></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Eligibility criteria – study design</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Published full texts:
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<ul><li class="half_rhythm"><div>Systematic reviews of RCTs</div></li><li class="half_rhythm"><div>RCTs</div></li><li class="half_rhythm"><div>Comparative cohort studies (only if RCTs unavailable or limited data to inform decision making)</div></li></ul>
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Conference abstracts of RCTs will only be considered if no evidence is available from full published RCTs (if no evidence from RCTs or comparative cohort studies available and are recent i.e., in the last 2 years-authors will be contacted for further information).</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other inclusion exclusion criteria</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>No sample size restriction</p>
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<p>No date restriction</p></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Proposed sensitivity/sub-group analysis, or meta-regression</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><u>Stratified analysis</u>
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<ul><li class="half_rhythm"><div>Babies born preterm, up to 28 days after their due birth date (preterm babies)</div></li><li class="half_rhythm"><div>Babies born at term, up to 28 days after their birth (term babies)</div></li></ul>
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Where evidence exists, consideration will be given to the specific needs of population subgroups:
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<ul><li class="half_rhythm"><div>Length of time on PN (first 2 weeks <i>vs</i>. later)</div></li><li class="half_rhythm"><div>Preterm (extremely preterm <28 weeks’ GA; very preterm: 28–31 weeks’ GA; moderately preterm: 32–36 weeks’ GA)</div></li><li class="half_rhythm"><div>Birth weight: Low birth weight (< 2500g); very low birth weight (< 1500g) and extremely low birth weight (< 1000g)</div></li><li class="half_rhythm"><div>Critically ill babies or those requiring surgery (for example, inotropic support, therapeutic hypothermia or fluid restriction)</div></li></ul>
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Important confounders (when comparative observational studies are included for interventional reviews):
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<ul><li class="half_rhythm"><div>Age of baby (first 2 weeks <i>vs</i>. later)</div></li><li class="half_rhythm"><div>Preterm (Very early <28 weeks’ GA; 28–31 weeks’ GA; 32–36 weeks’ GA)</div></li><li class="half_rhythm"><div>Birth weight: Low birth weight (< 2500g); very low birth weight (< 1500g) and extremely low birth weight (< 1000g)</div></li><li class="half_rhythm"><div>EN (in relation to length of hospital stay)</div></li></ul></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Selection process – duplicate screening/selection/analysis</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>Sifting, data extraction, appraisal of methodological quality and GRADE assessment will be performed by the systematic reviewer. Quality control will be performed by the senior systematic reviewer.</p>
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<p>A random sample of the references will be sifted by a second reviewer. This sample size will be 10% of the total, or 100 studies if the search identifies fewer than 1000 studies. All disagreements will be resolved by discussion between the two reviewers. The senior systematic reviewer or guideline lead will act as arbiter where necessary.</p></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data management (software)</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>Pair-wise meta-analysis, if possible, will be performed using Cochrane Review Manager (RevMan5).</p>
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<p>‘GRADEpro’ will be used to assess the quality of evidence for each outcome. Low income countries will be downgraded for indirectness.</p>
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<p>NGA STAR software will be used for generating bibliographies/citations, study sifting, data extraction and recording quality assessment using checklists (ROBIS (systematic reviews and meta-analyses); Cochrane risk of bias tool (RCTs or comparative cohort studies); Cochrane risk of bias tool (Non-randomised studies).</p></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Information sources – databases and dates</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>Sources to be searched: Medline, Medline In-Process, CCTR, CDSR, DARE, HTA, Embase.</p>
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<p>Limits (e.g. date, study design): All study designs. Apply standard animal/non-English language filters. No date limit. Supplementary search techniques: No supplementary search techniques were used.</p>
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<p>See <a href="#niceng154er18.appb">appendix B</a> for full strategies.</p></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Identify if an update</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">This is not an update</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Author contacts</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>Developer: The National Guideline Alliance</p>
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<p><a href="https://www.nice.org.uk/guidance/indevelopment/gid-ng10037" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.nice.org<wbr style="display:inline-block"></wbr>​.uk/guidance/indevelopment/gid-ng10037</a></p></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Highlight if amendment to previous protocol</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 4.5 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>
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<u>2014.</u></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Search strategy – for one database</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see <a href="#niceng154er18.appb">appendix B</a></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data collection process – forms/duplicate</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A standardised evidence table format will be used, and published as <a href="#niceng154er18.appd">appendix D</a> (clinical evidence tables) or <a href="#niceng154er18.apph">H</a> (economic evidence tables).</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Data items – define all variables to be collected</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see <a href="#niceng154er18.appb">appendix B</a>.</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for assessing bias at outcome/study level</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>Standard study checklists were used to critically appraise individual studies. For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>
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<u>2014.</u></p>
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<p>The risk of bias across all available evidence was evaluated for each outcome using an adaptation of the ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) toolbox’ developed by the international GRADE working group <a href="http://www.gradeworkinggroup.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.gradeworkinggroup.org/</a></p></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Criteria for quantitative synthesis (where suitable)</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.4 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>
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<u>2014.</u></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Methods for analysis – combining studies and exploring (in)consistency</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details of methods please see <a href="/books/NBK555673/bin/niceng154er18_bm3.pdf">supplementary material C</a>.</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Meta-bias assessment – publication bias, selective reporting bias</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see section 6.2 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>
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<u>2014.</u></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Assessment of confidence in cumulative evidence</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see sections 6.4 and 9.1 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>
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<u>2014.</u></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rationale/context – Current management</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">For details please see the <a href="#niceng154er18.s1.1.1">introduction</a> to the evidence review.</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Describe contributions of authors and guarantor</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"><p>A multidisciplinary committee developed the guideline. The committee was convened by the National Guideline Alliance and chaired by Joe Fawke (Consultant Neonatologist and Honorary Senior Lecturer, University Hospitals Leicester NHS Trust) in line with section 3 of <a href="https://www.nice.org.uk/article/pmg20/chapter/4-Developing-review-questions-and-planning-the-evidence-review#planning-the-evidence-review" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Developing NICE guidelines: the manual</a>
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<u>2014.</u></p>
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<p>Staff from the National Guideline Alliance undertook systematic literature searches, appraised the evidence, conducted meta-analysis and cost-effectiveness analysis where appropriate, and drafted the guideline in collaboration with the committee. For details of the methods please see <a href="/books/NBK555673/bin/niceng154er18_bm3.pdf">supplementary material C</a>.</p></td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sources of funding/support</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The National Guideline Alliance is funded by NICE and hosted by the Royal College of Obstetricians and Gynaecologists.</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Name of sponsor</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The National Guideline Alliance is funded by NICE and hosted by the Royal College of Obstetricians and Gynaecologists.</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Roles of sponsor</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICE funds the National Guideline Alliance to develop guidelines for those working in the NHS, public health, and social care in England.</td></tr><tr><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PROSPERO registration number</td><td headers="hd_h_niceng154er18.appa.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The review is not registered with PROSPERO.</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">CCTR: Cochrane controlled trials register; CDSR: Cochrane database of systematic reviews; DARE: database of abstracts of reviews of effects; GA: Gestational age; GRADE: Grading of Recommendations Assessment, Development and Evaluation; NICE: National Institute of Clinical Excellence; NGA: National Guideline Alliance; NHS: National Health Service; PN: Parenteral nutrition; PROSPERO: International prospective register of systematic reviews; RCT: randomised controlled trial.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobniceng154er18appbtab1"><div id="niceng154er18.appb.tab1" class="table"><h3><span class="title">Databases: Medline; Medline EPub Ahead of Print; and Medline In-Process & Other Non-Indexed Citations</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK555673/table/niceng154er18.appb.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__niceng154er18.appb.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">#</th><th id="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Searches</th></tr></thead><tbody><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INFANT, NEWBORN/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(neonat$ or newborn$ or new-born$ or baby or babies).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PREMATURE BIRTH/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((preterm$ or pre-term$ or prematur$ or pre-matur$) adj5 (birth? or born)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp INFANT, PREMATURE/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((preterm$ or pre-term$ or prematur$ or pre-matur$) adj5 infan$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pre#mie? or premie or premies).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp INFANT, LOW BIRTH WEIGHT/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(low adj3 birth adj3 weigh$ adj5 infan$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((LBW or VLBW) adj5 infan$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INTENSIVE CARE, NEONATAL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INTENSIVE CARE UNITS, NEONATAL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICU?.ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–13</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PARENTERAL NUTRITION/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PARENTERAL NUTRITION, TOTAL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PARENTERAL NUTRITION SOLUTIONS/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ADMINISTRATION, INTRAVENOUS/ and (nutrition$ or feed$ or fed$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INFUSIONS, INTRAVENOUS/ and (nutrition$ or feed$ or fed$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CATHETERIZATION, CENTRAL VENOUS/ and (nutrition$ or feed$ or fed$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp CATHETERIZATION, PERIPHERAL/ and (nutrition$ or feed$ or fed$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((parenteral$ or intravenous$ or intra-venous$ or IV or venous$ or infusion?) adj3 (nutrition$ or feed$ or fed$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((peripheral$ or central$) adj3 line? adj3 (nutrition$ or feed$ or fed$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(catheter$ adj3 (nutrition$ or feed$ or fed$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(drip? adj3 (nutrition$ or feed$ or fed$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/15–25</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PATIENT CARE TEAM/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((patient? or medical or health) adj1 care team).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((multidisciplinary or multi-disciplinary or multiprofession$ or multi-profession$ or integrated or network$) adj3 (team? or staff$ or task force? or approach$ or program$ or system? or panel? or forum? or group? or care or manag$ or service?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((interdisciplinary or inter-disciplinary or interprofession$ or inter-profession$ or integrated or network$) adj3 (team? or staff$ or task force? or approach$ or program$ or system? or panel? or forum? or group? or care or manag$ or service?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((transdisciplinary or trans-disciplinary or transprofession$ or trans-profession$) adj3 (team? or staff$ or task force? or approach$ or program$ or system? or panel? or forum? or group? or care or manag$ or service?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">mdt?.ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">network meeting?.ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/27–33</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INTERDISCIPLINARY COMMUNICATION/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((interdisciplinary or inter-disciplinary or interprofession$ or inter-profession$) adj3 (communic$ or collaborat$ or relation$)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((multidisciplinary or multi-disciplinary or multiprofession$ or multi-profession$) adj3 (communic$ or collaborat$ or relation$)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((transdisciplinary or trans-disciplinary or transprofession$ or trans-profession$) adj3 (communic$ or collaborat$ or relation$)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/35–38</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">COOPERATIVE BEHAVIOR/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((co-operat$ or cooperat$) adj3 (care or service? or practice?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((co-ordinat$ or coordinat$ or network$) adj3 (care or service? or practice?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/40–42</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MODELS, ORGANIZATIONAL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DELIVERY OF HEALTH CARE/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">"DELIVERY OF HEALTH CARE, INTEGRATED"/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or healthcare or organiz$ or organis$) adj3 model?).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(service? adj3 (deliver$ or configure$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/44–48</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(special$ adj2 (team? or approach$ or program$ or care or manag$ or service? or package?)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(compos$ adj3 team?).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pharmacist? or dietician? or neonatologist? or neonatal nurse? or biochemist? or lab$ specialist?).ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pharmacist? or dietician? or neonatologist? or neonatal nurse? or biochemist? or lab$ specialist?).ab. /freq=2</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/50–53</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nutrition$ adj3 (care or support$) adj3 team?).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 and 26 and 34</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 and 26 and 39</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 and 26 and 43</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 and 26 and 49</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 and 26 and 54</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14 and 55</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/56–61</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 62 to english language</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">LETTER/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EDITORIAL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NEWS/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp HISTORICAL ARTICLE/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ANECDOTES AS TOPIC/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">COMMENT/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CASE REPORT/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/64–71</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RANDOMIZED CONTROLLED TRIAL/ or random*.ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72 not 73</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ANIMALS/ not HUMANS/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp ANIMALS, LABORATORY/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp ANIMAL EXPERIMENTATION/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp MODELS, ANIMAL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp RODENTIA/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">80</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">81</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/74–80</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">82</td><td headers="hd_h_niceng154er18.appb.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63 not 81</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobniceng154er18appbtab2"><div id="niceng154er18.appb.tab2" class="table"><h3><span class="title">Databases: Embase; and Embase Classic</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK555673/table/niceng154er18.appb.tab2/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__niceng154er18.appb.tab2_lrgtbl__"><table><thead><tr><th id="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">#</th><th id="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Searches</th></tr></thead><tbody><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NEWBORN/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(neonat$ or newborn$ or new-born$ or baby or babies).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PREMATURITY/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((preterm$ or pre-term$ or prematur$ or pre-matur$) adj5 (birth? or born)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((preterm$ or pre-term$ or prematur$ or pre-matur$) adj5 infan$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pre#mie? or premie or premies).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp LOW BIRTH WEIGHT/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(low adj3 birth adj3 weigh$ adj5 infan$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((LBW or VLBW) adj5 infan$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NEWBORN INTENSIVE CARE/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NEONATAL INTENSIVE CARE UNIT/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICU?.ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/1–12</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PARENTERAL NUTRITION/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TOTAL PARENTERAL NUTRITION/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PERIPHERAL PARENTERAL NUTRITION/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PARENTERAL SOLUTIONS/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INTRAVENOUS FEEDING/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INTRAVENOUS DRUG ADMINISTRATION/ and (nutrition$ or feed$ or fed$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp INTRAVENOUS CATHETER/ and (nutrition$ or feed$ or fed$).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((parenteral$ or intravenous$ or intra-venous$ or IV or venous$ or infusion?) adj3 (nutrition$ or feed$ or fed$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((peripheral$ or central$) adj3 line? adj3 (nutrition$ or feed$ or fed$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(catheter$ adj3 (nutrition$ or feed$ or fed$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(drip? adj3 (nutrition$ or feed$ or fed$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/14–24</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*PATIENT CARE/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((patient? or medical or health) adj1 care team).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((multidisciplinary or multi-disciplinary or multiprofession$ or multi-profession$ or integrated or network$) adj3 (team? or staff$ or task force? or approach$ or program$ or system? or panel? or forum? or group? or care or manag$ or service?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((interdisciplinary or inter-disciplinary or interprofession$ or inter-profession$ or integrated or network$) adj3 (team? or staff$ or task force? or approach$ or program$ or system? or panel? or forum? or group? or care or manag$ or service?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((transdisciplinary or trans-disciplinary or transprofession$ or trans-profession$) adj3 (team? or staff$ or task force? or approach$ or program$ or system? or panel? or forum? or group? or care or manag$ or service?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">mdt?.ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">network meeting?.ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/26–32</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INTERDISCIPLINARY COMMUNICATION/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((interdisciplinary or inter-disciplinary or interprofession$ or inter-profession$) adj3 (communic$ or collaborat$ or relation$)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((multidisciplinary or multi-disciplinary or multiprofession$ or multi-profession$) adj3 (communic$ or collaborat$ or relation$)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((transdisciplinary or trans-disciplinary or transprofession$ or trans-profession$) adj3 (communic$ or collaborat$ or relation$)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/34–37</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*COOPERATION/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((co-operat$ or cooperat$) adj3 (care or service? or practice?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((co-ordinat$ or coordinat$ or network$) adj3 (care or service? or practice?)).ab,ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/39–41</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*NONBIOLOGICAL MODEL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">*HEALTH CARE DELIVERY/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INTEGRATED HEALTH CARE SYSTEM/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or healthcare or organiz$ or organis$) adj3 model?).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(service? adj3 (deliver$ or configure$)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/43–47</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(special$ adj2 (team? or approach$ or program$ or care or manag$ or service? or package?)).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(compos$ adj3 team?).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pharmacist? or dietician? or neonatologist? or neonatal nurse? or biochemist? or lab$ specialist?).ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pharmacist? or dietician? or neonatologist? or neonatal nurse? or biochemist? or lab$ specialist?).ab. /freq=2</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/49–52</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nutrition$ adj3 (care or support$) adj3 team?).ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 and 25 and 33</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 and 25 and 38</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 and 25 and 42</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 and 25 and 48</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 and 25 and 53</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13 and 54</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/55–60</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">limit 61 to english language</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">letter.pt. or LETTER/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">note.pt.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">65</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">editorial.pt.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">66</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CASE REPORT/ or CASE STUDY/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">67</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(letter or comment*).ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/63–67</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">69</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RANDOMIZED CONTROLLED TRIAL/ or random*.ti,ab.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">70</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">68 not 69</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">71</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ANIMAL/ not HUMAN/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">72</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NONHUMAN/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">73</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp ANIMAL EXPERIMENT/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">74</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp EXPERIMENTAL ANIMAL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">75</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ANIMAL MODEL/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">76</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">exp RODENT/</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(rat or rats or mouse or mice).ti.</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">78</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">or/70–77</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">79</td><td headers="hd_h_niceng154er18.appb.tab2_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62 not 78</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobniceng154er18appbtab3"><div id="niceng154er18.appb.tab3" class="table"><h3><span class="title">Databases: Cochrane Central Register of Controlled Trials; Cochrane Database of Systematic Reviews; Database of Abstracts of Reviews of Effects; and Health Technology Assessment</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK555673/table/niceng154er18.appb.tab3/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__niceng154er18.appb.tab3_lrgtbl__"><table><thead><tr><th id="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">#</th><th id="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Searches</th></tr></thead><tbody><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [INFANT, NEWBORN] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(neonat* or newborn* or new-born* or baby or babies):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">3</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [PREMATURE BIRTH] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((preterm* or pre-term* or prematur* or pre-matur*) near/5 (birth? or born)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [INFANT, PREMATURE] explode all trees</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">6</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((preterm* or pre-term* or prematur* or pre-matur*) near/5 infan*):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">7</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pre#mie? or premie or premies):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [INFANT, LOW BIRTH WEIGHT] explode all trees</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(low near/3 birth near/3 weigh* near/5 infan*):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((LBW or VLBW) near/5 infan*):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">11</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [INTENSIVE CARE, NEONATAL] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [INTENSIVE CARE UNITS, NEONATAL] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NICU?:ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">14</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">15</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [PARENTERAL NUTRITION] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">16</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [PARENTERAL NUTRITION, TOTAL] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">17</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [PARENTERAL NUTRITION SOLUTIONS] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [ADMINISTRATION, INTRAVENOUS] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">19</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [INFUSIONS, INTRAVENOUS] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [CATHETERIZATION, CENTRAL VENOUS] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">21</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [CATHETERIZATION, PERIPHERAL] explode all trees</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">22</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#18 or #19 or #20 or #21</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">23</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nutrition* or feed* or fed*):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#22 and #23</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">25</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((parenteral* or intravenous* or intra-venous* or IV or venous* or infusion?) near/3 (nutrition* or feed* or fed*)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((peripheral* or central*) near/3 line? near/3 (nutrition* or feed* or fed*)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(catheter* near/3 (nutrition* or feed* or fed*)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(drip? near/3 (nutrition* or feed* or fed*)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">29</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#15 or #16 or #17 or #24 or #25 or #26 or #27 or #28</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">30</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [PATIENT CARE TEAM] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">31</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((patient? or medical or health) near/1 care team):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">32</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((multidisciplinary or multi-disciplinary or multiprofession* or multi-profession* or integrated or network*) near/3 (team? or staff* or task force? or approach* or program* or system? or panel? or forum? or group? or care or manag* or service?)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">33</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((interdisciplinary or inter-disciplinary or interprofession* or inter-profession* or integrated or network*) near/3 (team? or staff* or task force? or approach* or program* or system? or panel? or forum? or group? or care or manag* or service?)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">34</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((transdisciplinary or trans-disciplinary or transprofession* or trans-profession*) near/3 (team? or staff* or task force? or approach* or program* or system? or panel? or forum? or group? or care or manag* or service?)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">35</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">mdt?:ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">network meeting?:ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">37</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#30 or #31 or #32 or #33 or #34 or #35 or #36</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">38</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [INTERDISCIPLINARY COMMUNICATION] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">39</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((interdisciplinary or inter-disciplinary or interprofession* or inter-profession*) near/3 (communic* or collaborat* or relation*)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">40</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((multidisciplinary or multi-disciplinary or multiprofession* or multi-profession*) near/3 (communic* or collaborat* or relation*)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">41</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((transdisciplinary or trans-disciplinary or transprofession* or trans-profession*) near/3 (communic* or collaborat* or relation*)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#38 or #39 or #40 or #41</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">43</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [COOPERATIVE BEHAVIOR] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">44</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((co-operat* or cooperat*) near/3 (care or service? or practice?)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((co-ordinat* or coordinat* or network*) near/3 (care or service? or practice?)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">46</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#43 or #44 or #45</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">47</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [MODELS, ORGANIZATIONAL] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">48</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [DELIVERY OF HEALTH CARE] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">49</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MeSH descriptor: [DELIVERY OF HEALTH CARE, INTEGRATED] this term only</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">((care or healthcare or organiz* or organis*) near/3 model?):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(service? near/3 (deliver* or configure*)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">52</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#47 or #48 or #49 or #50 or #51</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">53</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(special* near/2 (team? or approach* or program* or care or manag* or service? or package?)):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">54</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(compos* near/3 team?):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">55</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(pharmacist? or dietician? or neonatologist? or neonatal nurse? or biochemist? or lab* specialist?):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">56</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#53 or #54 or #55</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">57</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">(nutrition* near/3 (care or support*) near/3 team?):ti,ab</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">58</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14 and #29 and #37</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">59</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14 and #29 and #42</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">60</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14 and #29 and #46</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">61</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14 and #29 and #52</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">62</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14 and #29 and #56</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#14 and #57</td></tr><tr><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">64</td><td headers="hd_h_niceng154er18.appb.tab3_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">#58 or #59 or #60 or #61 or #62 or #63</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobniceng154er18appcfig1"><div id="niceng154er18.appc.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%201.%20PRISMA%20Flow%20chart%20of%20clinical%20article%20selection%20for%20review%20question%3A%20Are%20nutrition%20care%2Fsupport%20teams%20effective%20in%20providing%20PN%20in%20preterm%20and%20term%20babies%3F&p=BOOKS&id=555673_niceng154er18appcf1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK555673/bin/niceng154er18appcf1.jpg" alt="Figure 1. PRISMA Flow chart of clinical article selection for review question: Are nutrition care/support teams effective in providing PN in preterm and term babies?" class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 1</span><span class="title">PRISMA Flow chart of clinical article selection for review question: Are nutrition care/support teams effective in providing PN in preterm and term babies?</span></h3></div></article><article data-type="fig" id="figobniceng154er18appefig1"><div id="niceng154er18.appe.fig1" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%202.%20MDT%20versus%20no%20MDT%3B%20length%20of%20stay%20in%20NICU.&p=BOOKS&id=555673_niceng154er18appef1.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK555673/bin/niceng154er18appef1.jpg" alt="Figure 2. MDT versus no MDT; length of stay in NICU." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 2</span><span class="title">MDT versus no MDT; length of stay in NICU</span></h3></div></article><article data-type="fig" id="figobniceng154er18appefig2"><div id="niceng154er18.appe.fig2" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%203.%20MDT%20versus%20no%20MDT%3B%20mortality%20of%20babies.&p=BOOKS&id=555673_niceng154er18appef2.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK555673/bin/niceng154er18appef2.jpg" alt="Figure 3. MDT versus no MDT; mortality of babies." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 3</span><span class="title">MDT versus no MDT; mortality of babies</span></h3></div></article><article data-type="fig" id="figobniceng154er18appefig3"><div id="niceng154er18.appe.fig3" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Figure%204.%20MDT%20versus%20no%20MDT%3B%20Necrotising%20enterocolitis.&p=BOOKS&id=555673_niceng154er18appef3.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img data-src="/books/NBK555673/bin/niceng154er18appef3.jpg" alt="Figure 4. MDT versus no MDT; Necrotising enterocolitis." class="tileshop" title="Click on image to zoom" /></a></div><h3><span class="label">Figure 4</span><span class="title">MDT versus no MDT; Necrotising enterocolitis</span></h3></div></article><article data-type="table-wrap" id="figobniceng154er18appftab1"><div id="niceng154er18.appf.tab1" class="table"><h3><span class="label">Table 5</span><span class="title">Clinical evidence profile for MDT versus no MDT</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK555673/table/niceng154er18.appf.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__niceng154er18.appf.tab1_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_niceng154er18.appf.tab1_1_1_1_1" colspan="7" rowspan="1" style="text-align:left;vertical-align:bottom;">Quality assessment</th><th id="hd_h_niceng154er18.appf.tab1_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">No of patients</th><th id="hd_h_niceng154er18.appf.tab1_1_1_1_3" colspan="2" rowspan="1" style="text-align:left;vertical-align:bottom;">Effect</th><th id="hd_h_niceng154er18.appf.tab1_1_1_1_4" rowspan="2" colspan="1" headers="hd_h_niceng154er18.appf.tab1_1_1_1_4" style="text-align:left;vertical-align:bottom;">Quality</th><th id="hd_h_niceng154er18.appf.tab1_1_1_1_5" rowspan="2" colspan="1" headers="hd_h_niceng154er18.appf.tab1_1_1_1_5" style="text-align:left;vertical-align:bottom;">Importance</th></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1" id="hd_h_niceng154er18.appf.tab1_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No of studies</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1" id="hd_h_niceng154er18.appf.tab1_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Design</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1" id="hd_h_niceng154er18.appf.tab1_1_1_2_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Risk of bias</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1" id="hd_h_niceng154er18.appf.tab1_1_1_2_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Inconsistency</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1" id="hd_h_niceng154er18.appf.tab1_1_1_2_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Indirectness</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1" id="hd_h_niceng154er18.appf.tab1_1_1_2_6" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Imprecision</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1" id="hd_h_niceng154er18.appf.tab1_1_1_2_7" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Other considerations</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_2" id="hd_h_niceng154er18.appf.tab1_1_1_2_8" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">MDT</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_2" id="hd_h_niceng154er18.appf.tab1_1_1_2_9" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">No MDT</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_3" id="hd_h_niceng154er18.appf.tab1_1_1_2_10" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Relative (95% CI)</th><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_3" id="hd_h_niceng154er18.appf.tab1_1_1_2_11" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">Absolute</th></tr></thead><tbody><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_1_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Weight: z score at discharge (Better indicated by higher values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>1</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">122</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 0.16 higher (0.1 lower to 0.42 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_3_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Weight at discharge (Better indicated by higher values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 503 higher (327.23 to 678.77 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_5_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Weight: change in z score (Better indicated by higher values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>1</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">122</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 0.22 higher (0.01 lower to 0.45 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_7_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Weight gained (Better indicated by higher values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>3</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 478 higher (212.27 to 743.73 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_7_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_9_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Head circumference growth (Better indicated by higher values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>4</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 2 higher (0.91 to 3.09 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_9_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_11_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Head circumference at discharge (Better indicated by higher values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 2 higher (1.46 to 2.54 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<p>⨁◯◯◯</p>
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|
<p>VERY LOW</p>
|
|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_11_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_13_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Total length growth (Better indicated by higher values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 1 higher (1.08 lower to 3.08 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_13_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_15_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Length at discharge (Better indicated by higher values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>5</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">63</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">42</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 2 higher (0.77 to 3.23 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_15_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_17_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Length of stay - Babies with intestinal failure (Better indicated by lower values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>6</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>7</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 10 lower (49.73 lower to 29.73 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_17_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_19_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Length of stay - Babies with Gastroschisis (Better indicated by lower values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>6</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">204</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">192</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 13 higher (2.34 to 23.66 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_19_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_21_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Length of stay - Non-complex babies (Better indicated by lower values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>8</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>9</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">185</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">149</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 1.57 lower (17.74 lower to 14.6 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_21_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_23_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Energy greater than 80kcal/kg on day 7</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>1</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>10</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77/122 (63.1%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">45/107 (42.1%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.5 (1.16 to 1.95)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">210 more per 1000 (from 67 more to 400 more)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_23_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CRITICAL</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_25_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Duration of PN - Babies with intestinal failure (Better indicated by lower values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>6</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>11</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 63.7 higher (20.34 to 107.06 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_25_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_27_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Duration of PN - Babies with gastroschisis (Better indicated by lower values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>6</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>12</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">204</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">192</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 13 higher (4.59 to 21.41 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_27_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_29_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Duration of PN - Non-complex babies (Better indicated by lower values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>1</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious imprecision</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">122</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">107</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 4.4 lower (9.31 lower to 0.51 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_29_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_31_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Mortality - Babies with intestinal failure</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>6</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>13</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2/28 (7.1%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">4/27 (14.8%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.48 (0.1 to 2.42)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">77 fewer per 1000 (from 133 fewer to 210 more)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_31_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_33_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Mortality - Babies with gastroschisis</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>6</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>13</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">5/204 (2.5%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">10/192 (5.2%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 0.47 (0.16 to 1.35)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28 fewer per 1000 (from 44 fewer to 18 more)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_33_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_35_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Mortality - Non-complex babies</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>13</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">20/185 (10.8%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">8/149 (5.4%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.94 (0.47 to 8.09)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">50 more per 1000 (from 28 fewer to 381 more)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_35_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_37_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">NEC</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">2</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>2</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>13</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">13/185 (7%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">9/149 (6%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.20 (0.53 to 2.72)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">12 more per 1000 (from 29 fewer to 104 more)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_37_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_39_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Sepsis</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>1</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>13</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">36/122 (29.5%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">26/107 (24.3%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.21 (0.79 to 1.87)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">51 more per 1000 (from 51 fewer to 211 more)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
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|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_39_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_41_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Number of babies with at least 1 septic episode</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>6</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">serious<sup>10</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">24/28 (85.7%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">18/27 (66.7%)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">RR 1.29 (0.95 to 1.75)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">193 more per 1000 (from 33 fewer to 500 more)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
|
</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_41_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr><tr><th headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_h_niceng154er18.appf.tab1_1_1_1_5" id="hd_b_niceng154er18.appf.tab1_1_1_43_1" colspan="13" rowspan="1" style="text-align:left;vertical-align:middle;">Mean number of septic episodes per baby (Better indicated by lower values)</th></tr><tr><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_1 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_2 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">observational studies</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_3 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>6</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_4 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious inconsistency</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_5 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">no serious indirectness</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_6 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">very serious<sup>14</sup></td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_1 hd_h_niceng154er18.appf.tab1_1_1_2_7 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">none</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_8 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">28</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_2 hd_h_niceng154er18.appf.tab1_1_1_2_9 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">27</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_10 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">-</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_3 hd_h_niceng154er18.appf.tab1_1_1_2_11 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MD 0 higher (1.35 lower to 1.35 higher)</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_4 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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|
<p>⨁◯◯◯</p>
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<p>VERY LOW</p>
|
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</td><td headers="hd_h_niceng154er18.appf.tab1_1_1_1_5 hd_b_niceng154er18.appf.tab1_1_1_43_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">IMPORTANT</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_margin">CI: confidence interval; MD: mean difference; MDT: multidisciplinary team; PN: parenteral nutrition; RR: risk ratio.</p></div></dd></dl><dl class="bkr_refwrap"><dt>1</dt><dd><div id="niceng154er18.appf.tab1_1"><p class="no_margin">Very serious risk of bias due to moderate risk of confounding bias, and deviations from intended interventions, plus unclear risk of measurement bias.</p></div></dd></dl><dl class="bkr_refwrap"><dt>2</dt><dd><div id="niceng154er18.appf.tab1_2"><p class="no_margin">Very serious risk of bias due to serious risk of confounding bias, deviations from intended interventions, and selection of reported results. Unclear risk of bias from measurement bias.</p></div></dd></dl><dl class="bkr_refwrap"><dt>3</dt><dd><div id="niceng154er18.appf.tab1_3"><p class="no_margin">Evidence was downgraded by 1 due to serious imprecision, 95% confidence interval crosses one default MID for continuous outcomes, calculated as 0.5 × SD control at baseline (359).</p></div></dd></dl><dl class="bkr_refwrap"><dt>4</dt><dd><div id="niceng154er18.appf.tab1_4"><p class="no_margin">Evidence was downgraded by 1 due to serious imprecision, 95% confidence interval crosses one default MID for continuous outcomes, calculated as 0.5 × SD control at baseline (1.6).</p></div></dd></dl><dl class="bkr_refwrap"><dt>5</dt><dd><div id="niceng154er18.appf.tab1_5"><p class="no_margin">Evidence was downgraded by 1 due to serious imprecision, 95% confidence interval crosses one default MID for continuous outcomes, calculated as 0.5 × SD control at baseline (1.61).</p></div></dd></dl><dl class="bkr_refwrap"><dt>6</dt><dd><div id="niceng154er18.appf.tab1_6"><p class="no_margin">Very serious risk of bias due to serious risk of confounding bias, serious risk of classification bias, moderate risk of deviations from intended interventions, plus unclear risk of measurement bias.</p></div></dd></dl><dl class="bkr_refwrap"><dt>7</dt><dd><div id="niceng154er18.appf.tab1_7"><p class="no_margin">Evidence was downgraded by 1 due to serious imprecision, 95% confidence interval crosses one default MID for continuous outcomes, calculated as 0.5 × SD control at baseline (−30.4).</p></div></dd></dl><dl class="bkr_refwrap"><dt>8</dt><dd><div id="niceng154er18.appf.tab1_8"><p class="no_margin">Evidence downgraded due to heterogeneity in the data; I squared greater than 80%.</p></div></dd></dl><dl class="bkr_refwrap"><dt>9</dt><dd><div id="niceng154er18.appf.tab1_9"><p class="no_margin">Evidence was downgraded by 1 due to serious imprecision, 95% confidence interval crosses one default MID for continuous outcomes, calculated as 0.5 × SD control at baseline (17.66).</p></div></dd></dl><dl class="bkr_refwrap"><dt>10</dt><dd><div id="niceng154er18.appf.tab1_10"><p class="no_margin">Evidence was downgraded by 1 due to serious imprecision, 95% confidence interval crosses one default MID for dichotomous data (0.8 or 1.25).</p></div></dd></dl><dl class="bkr_refwrap"><dt>11</dt><dd><div id="niceng154er18.appf.tab1_11"><p class="no_margin">Evidence was downgraded by 1 due to serious imprecision, 95% confidence interval crosses one default MID for continuous outcomes, calculated as 0.5 × SD control at baseline (34.45).</p></div></dd></dl><dl class="bkr_refwrap"><dt>12</dt><dd><div id="niceng154er18.appf.tab1_12"><p class="no_margin">Evidence was downgraded by 1 due to serious imprecision, 95% confidence interval crosses one default MID for continuous outcomes, calculated as 0.5 × SD control at baseline (16.50).</p></div></dd></dl><dl class="bkr_refwrap"><dt>13</dt><dd><div id="niceng154er18.appf.tab1_13"><p class="no_margin">Evidence was downgraded by 2 due to very serious imprecision, 95% confidence interval crosses two default MID for dichotomous outcomes (0.8 and 1.25).</p></div></dd></dl><dl class="bkr_refwrap"><dt>14</dt><dd><div id="niceng154er18.appf.tab1_14"><p class="no_margin">Evidence was downgraded by 2 due to very serious imprecision, 95% confidence interval crosses both default MID for continuous outcomes, calculated as 0.5 × SD control at baseline (−1.33 and 1.33).</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobniceng154er18appktab1"><div id="niceng154er18.appk.tab1" class="table"><h3><span class="label">Table 6</span><span class="title">Excluded studies and reasons for their exclusion</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK555673/table/niceng154er18.appk.tab1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__niceng154er18.appk.tab1_lrgtbl__"><table><thead><tr><th id="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Study</th><th id="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Reason for Exclusion</th></tr></thead><tbody><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Arumugam, V., Arunan, S. K., Balasubramanian, G. P., Paruchuri, S., A prospective study on medication and total parenteral nutrition practices at a Neonatal Intensive Care Unit, Archives of Pharmacy Practice, 7, 142–148, 2016
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design and intervention do not meet protocol eligibility criteria; non-comparative, does not compare different nutrition care teams/individuals/no nutrition care team</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Cooke, R. J., Improving growth in preterm infants during initial hospital stay: Principles into practice, Archives of Disease in Childhood: Fetal and Neonatal Edition, 101, F366–F370, 2016 [<a href="https://pubmed.ncbi.nlm.nih.gov/26867763" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26867763</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-systematic review</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Fisher, A. A., Poole, R. L., Machie, R., Tsang, C., Baugh, N., Utley, K., Kerner, J. A., Jr., Clinical pathway for pediatric parenteral nutrition, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 12, 76–80, 1997 [<a href="https://pubmed.ncbi.nlm.nih.gov/9155406" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9155406</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design does not meet protocol eligibility criteria - no comparator; assesses implementation of a clinical pathway in single institution</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Geukers, V. G., de Neef, M., Dijsselhof, M. E., Sauerwein, H. P., Bos, A. P., Effect of a nurse-driven feeding algorithm and the institution of a nutritional support team on energy and macronutrient intake in critically ill children, e-SPEN Journal, 7, e35–e40, 2012
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study intervention does not meet protocol eligibility criteria; main nutrition from EN</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Gongwer, R. C., Gauvreau, K., Huh, S. Y., Sztam, K. A., Jenkins, K. J., Impact of a Standardized Clinical Assessment and Management Plan (SCAMP) on growth in infants with CHD, Cardiology in the Young, 28, 1093–1098, 2018 [<a href="https://pubmed.ncbi.nlm.nih.gov/30175701" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30175701</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population outside scope - older infants</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Gurgueira, G. L., Leite, H. P., Taddei, J. A., de Carvalho, W. B., Outcomes in a pediatric intensive care unit before and after the implementation of a nutrition support team, Jpen, Journal of parenteral and enteral nutrition. 29, 176–185, 2005 [<a href="https://pubmed.ncbi.nlm.nih.gov/15837777" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15837777</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study population do not meet protocol eligibility criteria; Mean age greater than 3 months</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Haddock, C., Al Maawali, A. G., Ting, J., Bedford, J., Afshar, K., Skarsgard, E. D., Impact of Multidisciplinary Standardization of Care for Gastroschisis: Treatment, Outcomes, and Cost, Journal of Pediatric Surgery, 53, 892–897, 2018 [<a href="https://pubmed.ncbi.nlm.nih.gov/29499843" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29499843</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study intervention does not meet protocol eligibility criteria; care for gastroschisis, focus not on PN</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Johnson, Mark J., Leaf, Alison A., Pearson, Freya, Clark, Howard W., Dimitrov, Borislav D., Pope, Catherine, May, Carl R., Successfully implementing and embedding guidelines to improve the nutrition and growth of preterm infants in neonatal intensive care: a prospective interventional study, BMJ open, 7, e017727, 2017 [<a href="/pmc/articles/PMC5728292/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5728292</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/29217722" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29217722</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Insufficient presentation of results for analysis</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Johnson, T., Sexton, E., Managing children and adolescents on parenteral nutrition: Challenges for the nutritional support team, Proceedings of the Nutrition Society, 65, 217–221, 2006 [<a href="https://pubmed.ncbi.nlm.nih.gov/16923305" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16923305</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Non-systematic review</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Kaufman, Jon, Vichayavilas, Piyagarnt, Rannie, Michael, Peyton, Christine, Carpenter, Esther, Hull, Danielle, Alpern, Jennifer, Barrett, Cindy, da Cruz, Eduardo M., Roosevelt, Genie, Improved nutrition delivery and nutrition status in critically ill children with heart disease, Pediatrics, 135, e717–25, 2015 [<a href="https://pubmed.ncbi.nlm.nih.gov/25687139" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25687139</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Population do not meet the inclusion criteria; median age of 1.6 months</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Koehler, A. N., Yaworski, J. A., Gardner, M., Kocoshis, S., Reyes, J., Barksdale, E. M., Jr., Coordinated interdisciplinary management of pediatric intestinal failure: a 2-year review, Journal of Pediatric Surgery, 35, 380–5, 2000 [<a href="https://pubmed.ncbi.nlm.nih.gov/10693701" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10693701</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design does not meet protocol eligibility criteria; non-comparative study</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Kuzma-O’Reilly, Barbara, Duenas, Maria L., Greecher, Coleen, Kimberlin, Lois, Mujsce, Dennis, Miller, Debra, Walker, Donna Jean, Evaluation, development, and implementation of potentially better practices in neonatal intensive care nutrition, Pediatrics, 111, e461–70, 2003 [<a href="https://pubmed.ncbi.nlm.nih.gov/12671166" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12671166</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design and intervention do not meet protocol eligibility criteria; non-comparative study with a focus on enteral nutrition</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Merras-Salmio, L., Pakarinen, M. P., Refined Multidisciplinary Protocol-Based Approach to Short Bowel Syndrome Improves Outcomes, Journal of Pediatric Gastroenterology and Nutrition, 61, 24–29, 2015 [<a href="https://pubmed.ncbi.nlm.nih.gov/25729889" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25729889</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study intervention does not meet protocol eligibility criteria; changes in EN protocol</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Modi, Biren P., Langer, Monica, Ching, Y. Avery, Valim, Clarissa, Waterford, Stephen D., Iglesias, Julie, Duro, Debora, Lo, Clifford, Jaksic, Tom, Duggan, Christopher, Improved survival in a multidisciplinary short bowel syndrome program, Journal of Pediatric Surgery, 43, 20–4, 2008 [<a href="/pmc/articles/PMC3253359/" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3253359</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18206449" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18206449</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design does not meet protocol eligibility criteria; non-comparative study</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Muir, A., Holden, C., Sexton, E., Gray, J. W., Preventing bloodstream infection in patients receiving home parenteral nutrition, Journal of Pediatric Gastroenterology and Nutrition, 59, 177–181, 2014 [<a href="https://pubmed.ncbi.nlm.nih.gov/24796804" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24796804</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study intervention does not meet protocol eligibility criteria; enhanced clinical pathway that does not focus on PN</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Olsen, Irene E., Richardson, Douglas K., Schmid, Christopher H., Ausman, Lynne M., Dwyer, Johanna T., Dietitian involvement in the neonatal intensive care unit: more is better, Journal of the American Dietetic Association, 105, 1224–30, 2005 [<a href="https://pubmed.ncbi.nlm.nih.gov/16182638" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16182638</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study design does not meet inclusion criteria - cross sectional study</td></tr><tr><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Sigalet, David, Boctor, Dana, Brindle, Mary, Lam, Viona, Robertson, Marli, Elements of successful intestinal rehabilitation, Journal of Pediatric Surgery, 46, 150–6, 2011 [<a href="https://pubmed.ncbi.nlm.nih.gov/21238657" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21238657</span></a>]
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</td><td headers="hd_h_niceng154er18.appk.tab1_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Study intervention does not meet protocol eligibility criteria; study assesses pre- and post-implementation of standardised protocol</td></tr></tbody></table></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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