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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]" /><meta name="citation_title" content="Doxylamine" /><meta name="citation_publisher" content="National Institute of Diabetes and Digestive and Kidney Diseases" /><meta name="citation_date" content="2017/01/16" /><meta name="citation_pmid" content="31644135" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK548828/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Doxylamine" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Diabetes and Digestive and Kidney Diseases" /><meta name="DC.Date" content="2017/01/16" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK548828/" /><meta name="description" content="Doxylamine is a first generation antihistamine that is used for symptoms of allergic rhinitis and the common cold and as a short acting sedative. Doxylamine has not been linked to instances of clinically apparent acute liver injury." /><meta name="og:title" content="Doxylamine" /><meta name="og:type" content="book" /><meta name="og:description" content="Doxylamine is a first generation antihistamine that is used for symptoms of allergic rhinitis and the common cold and as a short acting sedative. Doxylamine has not been linked to instances of clinically apparent acute liver injury." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK548828/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/livertox/Doxylamine/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK548828/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK548828_"><span class="title" itemprop="name">Doxylamine</span></h1><p class="small">Last Update: <span itemprop="dateModified">January 16, 2017</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="Doxylamine.OVERVIEW"><h2 id="_Doxylamine_OVERVIEW_">OVERVIEW</h2><div id="Doxylamine.Introduction"><h3>Introduction</h3><p>Doxylamine is a first generation antihistamine that is used for symptoms of allergic rhinitis and the common cold and as a short acting sedative. Doxylamine has not been linked to instances of clinically apparent acute liver injury.</p></div><div id="Doxylamine.Background"><h3>Background</h3><p>Doxylamine (dox il' a meen) is a first generation antihistamine that is used to treat the symptoms of allergic rhinitis and the common cold, including sneezing, cough, runny note, watery eyes and itching. Because of its sedating side effects, it is also used as a mild sleeping aid and sedative. Doxylamine belongs to the ethanolamine class of antihistamines (with clemastine and dimenhydrinate) and was approved for use in the United States in 1948. It is still widely used today, largely in combination with other agents such as dextromethorphan, pseudoephedrine, aspirin and acetaminophen in over-the-counter products for relief of symptoms of the common cold and allergic rhinitis. Representative brand names of products that include doxylamine include Alka-Seltzer Plus, Night Time Cold/Flu Relief, NyQuil, and Sleep Aid. The recommended adult oral dose is 25 to 50 mg. Common side effects include sedation, impairment of motor function, confusion, dizziness, blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache. Antihistamines can worsen urinary retention and glaucoma.</p></div><div id="Doxylamine.Hepatotoxicity"><h3>Hepatotoxicity</h3><p>Despite widespread use over many decades, doxylamine has not been linked to liver test abnormalities or to clinically apparent liver injury. The reason for its safety may relate its short half-life and limited duration of use.</p><p>Likelihood score: E (unlikely to be a cause of clinically apparent liver injury).</p><p>References on the safety and potential hepatotoxicity of antihistamines are given together after the Overview section on Antihistamines.</p><p>Drug Class: <a href="/books/n/livertox/Antihistamines/">Antihistamines</a></p></div></div><div id="Doxylamine.PRODUCT_INFORMATION"><h2 id="_Doxylamine_PRODUCT_INFORMATION_">PRODUCT INFORMATION</h2><div id="Doxylamine.BPI" class="box"><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Doxylamine – Generic, Sleep Aid®, Unisom®</p><p>
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<b>DRUG CLASS</b>
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</p><p>Antihistamines</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Doxylamine" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div></div><div id="Doxylamine.CHEMICAL_FORMULA_AND_STRUCTUR"><h2 id="_Doxylamine_CHEMICAL_FORMULA_AND_STRUCTUR_">CHEMICAL FORMULA AND STRUCTURE</h2><div id="Doxylamine.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK548828/table/Doxylamine.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Doxylamine.T1_lrgtbl__"><table><thead><tr><th id="hd_h_Doxylamine.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">DRUG</th><th id="hd_h_Doxylamine.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">CAS REGISTRY NUMBER</th><th id="hd_h_Doxylamine.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">MOLECULAR FORMULA</th><th id="hd_h_Doxylamine.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">STRUCTURE</th></tr></thead><tbody><tr><td headers="hd_h_Doxylamine.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">Doxylamine</td><td headers="hd_h_Doxylamine.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">469-21-6</td><td headers="hd_h_Doxylamine.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">C17-H22-N2-O</td><td headers="hd_h_Doxylamine.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">
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<div class="graphic"><img src="/books/NBK548828/bin/Doxylamine_Structure.jpg" alt="Doxylamine Chemical Structure" /></div>
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