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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]" /><meta name="citation_title" content="Methocarbamol" /><meta name="citation_publisher" content="National Institute of Diabetes and Digestive and Kidney Diseases" /><meta name="citation_date" content="2017/01/30" /><meta name="citation_pmid" content="31643609" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK548286/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Methocarbamol" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Diabetes and Digestive and Kidney Diseases" /><meta name="DC.Date" content="2017/01/30" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK548286/" /><meta name="description" content="Methocarbamol is a commonly used, centrally acting muscle relaxant and has not been linked to instances of liver injury." /><meta name="og:title" content="Methocarbamol" /><meta name="og:type" content="book" /><meta name="og:description" content="Methocarbamol is a commonly used, centrally acting muscle relaxant and has not been linked to instances of liver injury." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK548286/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-livertox-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/livertox/Methocarbamol/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK548286/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK548286_"><span class="title" itemprop="name">Methocarbamol</span></h1><p class="small">Last Update: <span itemprop="dateModified">January 30, 2017</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="Methocarbamol.OVERVIEW"><h2 id="_Methocarbamol_OVERVIEW_">OVERVIEW</h2><div id="Methocarbamol.Introduction"><h3>Introduction</h3><p>Methocarbamol is a commonly used, centrally acting muscle relaxant and has not been linked to instances of liver injury.</p></div><div id="Methocarbamol.Background"><h3>Background</h3><p>Methocarbamol (meth" oh kar' ba mol) is a guaifenesin derivative and acts centrally as a muscle relaxant by an unknown mechanism. Methocarbamol was approved for use in the United States in 1957, and currently more than 3 million prescriptions are filled yearly. Methocarbamol is indicated for the relief of acute, painful musculoskeletal conditions. Methocarbamol is available in 500 and 750 mg tablets in several generic formulations, both alone and in combination with other drugs and under the brand names of Robaxin and Marbaxin. The recommended dosage is 1500 mg orally three to four times daily. The most common side effects of methocarbamol are drowsiness blurred vision, headache, nausea and skin rash.</p></div><div id="Methocarbamol.Hepatotoxicity"><h3>Hepatotoxicity</h3><p>While the product label for methocarbamol states that it can cause jaundice (including cholestatic jaundice), there is little published evidence to suggest that methocarbamol is a cause of hepatic injury or clinically apparent drug induced liver disease. During clinical trials of methocarbamol, some patients had to stop treatment because of nausea, dizziness, or other nonspecific complaints, but no serum aminotransferase levels or other laboratory results were reported. Methocarbamol appears to be well tolerated, but the lack of monitoring of serum aminotransferase levels during clinical trials with methocarbamol makes it impossible to rule out the possibility of mild liver injury occurring with treatment.</p><p>Likelihood score: E (Unlikely cause of clinically apparent liver injury).</p><p>Drug Class: <a href="/books/n/livertox/MuscleRelaxants/">Muscle Relaxants</a></p></div></div><div id="Methocarbamol.PRODUCT_INFORMATION_Muscle"><h2 id="_Methocarbamol_PRODUCT_INFORMATION_Muscle_">PRODUCT INFORMATION</h2><div id="Methocarbamol.BPI" class="box"><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Methocarbamol – Generic, Robaxin®</p><p>
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<b>DRUG CLASS</b>
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</p><p>Autonomic Agents: Muscle Relaxants, Central</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=methocarbamol" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div></div><div id="Methocarbamol.CHEMICAL_FORMULA_AND_STRUC"><h2 id="_Methocarbamol_CHEMICAL_FORMULA_AND_STRUC_">CHEMICAL FORMULA AND STRUCTURE</h2><div id="Methocarbamol.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK548286/table/Methocarbamol.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Methocarbamol.T1_lrgtbl__"><table><thead><tr><th id="hd_h_Methocarbamol.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">DRUG</th><th id="hd_h_Methocarbamol.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">CAS REGISTRY NO</th><th id="hd_h_Methocarbamol.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">MOLECULAR FORMULA</th><th id="hd_h_Methocarbamol.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">STRUCTURE</th></tr></thead><tbody><tr><td headers="hd_h_Methocarbamol.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">Methocarbamol</td><td headers="hd_h_Methocarbamol.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134976672" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">532-03-6</a>
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</td><td headers="hd_h_Methocarbamol.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">C11-H15-N-O5</td><td headers="hd_h_Methocarbamol.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">
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<div class="graphic"><img src="/books/NBK548286/bin/Methocarbamol_Structure.jpg" alt="Methocarbamol chemical structure" /></div>
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</td></tr></tbody></table></div></div></div><div id="Methocarbamol.ANNOTATED_BIBLIOGRAPHY"><h2 id="_Methocarbamol_ANNOTATED_BIBLIOGRAPHY_">ANNOTATED BIBLIOGRAPHY</h2><p>References updated: 30 January 2017</p><ul class="first-line-outdent"><li><div class="bk_ref" id="Methocarbamol.R1">Zimmerman HJ. Muscle spasmolytics. In, Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. 2nd Ed. Philadelphia: Lippincott, 1999. p. 544-45. <div><i>(Expert review of hepatotoxicity published in 1999; discussed dantrolene, chlorzoxazone and baclofen, but not methocaramol).</i></div></div></li><li><div class="bk_ref" id="Methocarbamol.R2">Hibbs RE, Zambon AC. Agents acting at the neuromuscular junction and autonomic ganglia. In, Brunton LL, Chabner BA, Knollman BC, eds. Goodman & Gilman’s The pharmacological basis of therapeutics, 12th ed. New York: McGraw-Hill, 2011. p. 255-76.<div><i>(Textbook of pharmacology and therapeutics).</i></div></div></li><li><div class="bk_ref" id="Methocarbamol.R3">Chou R, Peterson K, Helfand M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage 2004; 28: 140-75. [<a href="https://pubmed.ncbi.nlm.nih.gov/15276195" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15276195</span></a>]<div><i> (Thorough review of the pharmacology, efficacy and side effects of the muscle relaxants).</i></div></div></li><li><div class="bk_ref" id="Methocarbamol.R4">Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, et al.; United States Drug Induced Liver Injury Network. Features and outcomes of 899 patients with drug-induced liver injury: The DILIN Prospective Study. Gastroenterology 2015; 148: 1340-1352.e7. [<a href="/pmc/articles/PMC4446235/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4446235</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25754159" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25754159</span></a>]<div><i>(Among 899 cases of drug induced liver injury enrolled in a US prospective study between 2004 and 2013, 5 [0.7%] were attributed to muscle relaxants, including dantrolene, baclofen, chlorzoxazone and metaxalone, but none were linked to use of methocarbamol).</i></div></div></li></ul></div><div id="bk_toc_contnr"></div></div></div>
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