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<meta name="citation_inbook_title" content="LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]">
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yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK547935_"><span class="title" itemprop="name">Loperamide</span></h1><p class="fm-aai"><a href="#_NBK547935_pubdet_">Publication Details</a></p></div></div><div class="body-content whole_rhythm" itemprop="text"><div id="Loperamide.OVERVIEW"><h2 id="_Loperamide_OVERVIEW_">OVERVIEW</h2><div id="Loperamide.Introduction"><h3>Introduction</h3><p>Loperamide is synthetic opioid that primarily affects opiate receptors in the intestine and is used to treat diarrhea. Loperamide has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.</p></div><div id="Loperamide.Background"><h3>Background</h3><p>Loperamide (loe per’ a mide) is a synthetic piperidine derivative that acts as a mild opiate receptor agonist (predominant µ type receptors), but is used largely for the treatment of diarrhea rather than pain. Loperamide is not structurally related to morphine or codeine and has minimal or no euphoric or analgesic effects, apparently because it is poorly absorbed orally and is actively transported out of the central nervous system. Loperamide acts as a potent opiate agonist in the intestine and reduces intestinal motility, causing a slowing of intestinal transport and increased resorption of water and electrolytes, actions that are helpful in treating diarrhea. Loperamide was approved for use in the United States in 1976 and is still widely used to treat acute diarrhea caused by gastroenteritis, as well as the chronic diarrhea of inflammatory bowel disease. Loperamide is available as tablets and capsules of 2 mg and solution of 1 mg/5 mL generically and under the brand name Imodium. The usual dose of loperamide in adults is 4 mg initially, followed by 2 mg after each unformed stool, not to exceed 16 mg daily. Side effects of loperamide include abdominal bloating and pain, nausea and vomiting and constipation. Rare side effects include hypersensitivity reactions and paralytic ileus. Loperamide is not classified as a controlled substance and several formulations are available without prescription.</p></div><div id="Loperamide.Hepatotoxicity"><h3>Hepatotoxicity</h3><p>As with most opiates in current use, therapy with loperamide has not been linked to serum enzyme elevations. There have been no convincing cases of idiosyncratic acute, clinically apparent liver injury attributed to either agent. The reason for its lack of hepatotoxicity may relate to the low doses used and lack of significant systemic absorption. What loperamide is absorbed is metabolized in the liver.</p><p>References on the safety and potential hepatotoxicity of loperamide are given in the overview section of the Opioids. Last updated: 20 May 2019</p><p>Drug Class: <a href="/books/n/livertox/GastrointestinalAgen/?report=reader">Gastrointestinal Agents</a>; <a href="/books/n/livertox/Opioids/?report=reader">Opioids</a></p></div></div><div id="Loperamide.PRODUCT_INFORMATION"><h2 id="_Loperamide_PRODUCT_INFORMATION_">PRODUCT INFORMATION</h2><div id="Loperamide.BPI" class="box boxed-text-box whole_rhythm hide-overflow"><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Loperamide – Generic, Imodium®</p><p>
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<b>DRUG CLASS</b>
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</p><p>Gastrointestinal Agents; Opioids</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Loperamide" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div></div><div id="Loperamide.CHEMICAL_FORMULA_AND_STRUCTUR"><h2 id="_Loperamide_CHEMICAL_FORMULA_AND_STRUCTUR_">CHEMICAL FORMULA AND STRUCTURE</h2><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figLoperamideT1"><a href="/books/NBK547935/table/Loperamide.T1/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figLoperamideT1" rid-ob="figobLoperamideT1"><img class="small-thumb" src="/books/NBK547935/table/Loperamide.T1/?report=thumb" src-large="/books/NBK547935/table/Loperamide.T1/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="Loperamide.T1"><a href="/books/NBK547935/table/Loperamide.T1/?report=objectonly" target="object" rid-ob="figobLoperamideT1">Table</a></h4></div></div></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK547935_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Update: <span itemprop="dateModified">April 25, 2019</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="https://www.niddk.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Diabetes and Digestive and Kidney Diseases</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Loperamide. [Updated 2019 Apr 25].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/livertox/LoopDiuretics/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/livertox/Lopinavir/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="boxed-text" id="figobLoperamideBPI"><div id="Loperamide.BPI" class="box boxed-text-box whole_rhythm hide-overflow"><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Loperamide – Generic, Imodium®</p><p>
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<b>DRUG CLASS</b>
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</p><p>Gastrointestinal Agents; Opioids</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Loperamide" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div></article><article data-type="table-wrap" id="figobLoperamideT1"><div id="Loperamide.T1" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK547935/table/Loperamide.T1/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Loperamide.T1_lrgtbl__"><table><thead><tr><th id="hd_h_Loperamide.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">DRUG</th><th id="hd_h_Loperamide.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">CAS REGISTRY NO.</th><th id="hd_h_Loperamide.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">MOLECULAR FORMULA</th><th id="hd_h_Loperamide.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">STRUCTURE</th></tr></thead><tbody><tr><td headers="hd_h_Loperamide.T1_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">Loperamide</td><td headers="hd_h_Loperamide.T1_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">53179-11-6</td><td headers="hd_h_Loperamide.T1_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">C29-H33-Cl-N2-O2</td><td headers="hd_h_Loperamide.T1_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">
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<div class="graphic"><img src="/books/NBK547935/bin/Loperamide_Structure.jpg" alt="Loperamide Chemical Structure" /></div>
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