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yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK547859_"><span class="title" itemprop="name">Triamterene</span></h1><p class="fm-aai"><a href="#_NBK547859_pubdet_">Publication Details</a></p></div></div><div class="body-content whole_rhythm" itemprop="text"><div id="Triamterene.OVERVIEW"><h2 id="_Triamterene_OVERVIEW_">OVERVIEW</h2><div id="Triamterene.Introduction"><h3>Introduction</h3><p>Triamterene is a potassium-sparing diuretic widely used in the therapy of edema. Triamterene has been linked to rare cases of clinically apparent drug induced liver disease.</p></div><div id="Triamterene.Background"><h3>Background</h3><p>Triamterene (trye am' ter een) is an inhibitor of renal epithelial sodium channels in the late distal tubule and collecting ducts of the kidney. As a result, triamterene promotes a mild sodium diuresis, but maintains body potassium levels. Triamterene is used largely in therapy of edema and can be safely used in patients with cirrhosis. Because of its potassium-sparing actions, triamterene is also used in combination with thiazide or loop diuretics in an attempt to prevent hypokalemia. Triamterene was approved for use in the United States in 1964 and continues to be widely used with more than 20 million prescriptions filled yearly. Triamterene is available in tablets and capsules of 50 and 100 mg in generic forms and under the brand name of Dyrenium. The typical dose of triamterene is 50 to 200 mg daily in one or two divided doses. Triamterene is also available in fixed dose combinations with hydrochlorothiazide (Maxide, Dyazide and generically). Triamterene is usually well tolerated but side effects can include dizziness, fatigue, headache, dry mouth, hyperkalemia and dehydration. Rare but potentially severe adverse events include rash, photosensitivity, and anaphylaxis.</p></div><div id="Triamterene.Hepatotoxicity"><h3>Hepatotoxicity</h3><p>Triamterene therapy has been associated with rare instances of idiosyncratic, clinically apparent liver injury which have invariably been mild and anicteric. The liver injury typically arises after 4 to 12 weeks of therapy and the pattern of serum enzyme elevations is usually hepatocellular or mixed. Fever is a prominent symptom and the reaction is often more typical of drug-fever than hepatotoxicity (Case 1). Rash and eosinophilia can occur, but are usually not prominent. Autoantibodies are rare. All published cases of triamterene associated liver injury have been self-limited in course and resolved rapidly upon withdrawal.</p><p>Likelihood score: D (possible rare cause of clinically apparent liver injury).</p></div><div id="Triamterene.Mechanism_of_Injury"><h3>Mechanism of Injury</h3><p>The mechanism of triamterene hepatic injury is unknown, but it likely to be due to hypersensitivity.</p></div><div id="Triamterene.Outcome_and_Management"><h3>Outcome and Management</h3><p>Most instances of triamterene associated liver injury have been mild and rapidly reversible upon drug withdrawal. Rapid recurrence upon rechallenge has been reported. There is no evidence of cross reactivity to the hepatic injury with other diuretics.</p><p>Drug Class: <a href="/books/n/livertox/Diuretics/?report=reader">Diuretics</a>, Potassium-Sparing Diuretics</p><p>Other Drugs in the Subclass: <a href="/books/n/livertox/Amiloride/?report=reader">Amiloride</a>, <a href="/books/n/livertox/Eplerenone/?report=reader">Eplerenone</a>, <a href="/books/n/livertox/Spironolactone/?report=reader">Spironolactone</a></p></div></div><div id="Triamterene.CASE_REPORT"><h2 id="_Triamterene_CASE_REPORT_">CASE REPORT</h2><div id="Triamterene.Case_1_Triamterene_induced_f"><h3>Case 1. Triamterene induced fever and liver injury.(<a class="bibr" href="#Triamterene.REF.1" rid="Triamterene.REF.1">1</a>)</h3><p>A 44 year old woman developed fever, malaise and right upper quadrant pain one month after starting triamterene (100 mg daily) for peripheral edema. On examination, she was febrile (39<sup>o</sup> C) and had hepatic tenderness, but no rash or lymphadenopathy. Laboratory tests showed elevations in serum enzymes with AST 428 U/L and Alk P 170 U/L and slightly elevated total white blood cell count (12,000/µL). Abdominal ultrasound showed fatty liver, but no evidence of biliary obstruction. Serum bilirubin levels, prothrombin time, hepatitis A or B markers and autoantibodies were not mentioned. Triamterene was stopped and her fever abated. She was discharged but presented 1 day later with recurrence of symptoms and fever. The white blood cell count was again raised and was accompanied by eosinophilia (2,520/µL). Serum enzymes were more elevated than before. Careful history revealed that she had restarted triamterene six hours before the reappearance of fever. Withholding further triamterene therapy was followed by resolution of fever and fall of white count and liver test abnormalities to normal levels within 6 days.</p><div id="Triamterene.Key_Points"><h4>Key Points</h4><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figTriamtereneTc"><a href="/books/NBK547859/table/Triamterene.Tc/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figTriamtereneTc" rid-ob="figobTriamtereneTc"><img class="small-thumb" src="/books/NBK547859/table/Triamterene.Tc/?report=thumb" src-large="/books/NBK547859/table/Triamterene.Tc/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="Triamterene.Tc"><a href="/books/NBK547859/table/Triamterene.Tc/?report=objectonly" target="object" rid-ob="figobTriamtereneTc">Table</a></h4></div></div></div><div id="Triamterene.Comment"><h4>Comment</h4><p>This patient developed drug fever one month after starting triamterene and had an accompanying increase in liver enzyme values. Rechallenge let to a prompt recurrence. These features were compatible with a hypersensitivity reaction with minor hepatic involvement. While rash and drug fever have been described with triamterene therapy, acute liver injury with jaundice has not.</p></div></div></div><div id="Triamterene.PRODUCT_INFORMATION"><h2 id="_Triamterene_PRODUCT_INFORMATION_">PRODUCT INFORMATION</h2><p>
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<b>REPRESENTATIVE TRADE NAMES</b>
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</p><p>Triamterene – Generic, Dyrenium®</p><p>
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<b>DRUG CLASS</b>
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</p><p>Diuretics</p><p>
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<a href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Triamterene" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">COMPLETE LABELING</a>
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</p><p>Product labeling at DailyMed, National Library of Medicine, NIH</p></div><div id="Triamterene.CHEMICAL_FORMULA_AND_STRUCTU"><h2 id="_Triamterene_CHEMICAL_FORMULA_AND_STRUCTU_">CHEMICAL FORMULA AND STRUCTURE</h2><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figTriamtereneTd"><a href="/books/NBK547859/table/Triamterene.Td/?report=objectonly" target="object" title="Table" class="img_link icnblk_img figpopup" rid-figpopup="figTriamtereneTd" rid-ob="figobTriamtereneTd"><img class="small-thumb" src="/books/NBK547859/table/Triamterene.Td/?report=thumb" src-large="/books/NBK547859/table/Triamterene.Td/?report=previmg" alt="Image " /></a><div class="icnblk_cntnt"><h4 id="Triamterene.Td"><a href="/books/NBK547859/table/Triamterene.Td/?report=objectonly" target="object" rid-ob="figobTriamtereneTd">Table</a></h4></div></div></div><div id="Triamterene.CITED_REFERENCES"><h2 id="_Triamterene_CITED_REFERENCES_">CITED REFERENCES</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="Triamterene.REF.1">Nolan PJ, D’Arcy G. Triamterene drug fever and hepatitis. <span><span class="ref-journal">Med J Aust. </span>1987;<span class="ref-vol">147</span>:262.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/3670184" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3670184</span></a>]</div></dd></dl></dl></div><div id="Triamterene.ANNOTATED_BIBLIOGRAPHY"><h2 id="_Triamterene_ANNOTATED_BIBLIOGRAPHY_">ANNOTATED BIBLIOGRAPHY</h2><p>References updated: 13 October 2021</p><ul class="first-line-outdent"><li><div class="bk_ref" id="Triamterene.REF.zimmerman.1999">Zimmerman HJ. Diuretic drugs. Drugs used in cardiovascular disease. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott, 1999, pp. 662-4.<div><i>(Expert review of hepatotoxicity of diuretics published in 1999 mentions that clinically apparent liver injury due to diuretics is rare; hepatocellular jaundice has been reported with triamterene).</i></div></div></li><li><div class="bk_ref" id="Triamterene.REF.de_marzio.2013">De Marzio DH, Navarro VJ. Hepatotoxicity of cardiovascular and antidiabetic drugs. In, Kaplowitz N, DeLeve LD, eds. Drug-induced liver disease. 3rd ed. Amsterdam: Elsevier, 2013, pp. 519-40.<div><i>(Review of hepatotoxicity of cardiovascular agents, mentions that thiazide diuretics can rarely cause cholestatic hepatitis; no mention of potassium sparing diuretics).</i></div></div></li><li><div class="bk_ref" id="Triamterene.REF.jackson.2018">Jackson EK. Drugs affecting renal excretory function. In, Brunton LL, Hilal-Dandan R, Knollman BC, eds. Goodman & Gilman’s the pharmacological basis of therapeutics. 13th ed. New York: McGraw-Hill, 2018, pp. 445-70.<div><i>(Textbook of pharmacology and therapeutics).</i></div></div></li><li><div class="bk_ref" id="Triamterene.REF.safdi.1980.701">Safdi MA. Fever secondary to triamterene therapy. <span><span class="ref-journal">N Engl J Med. </span>1980;<span class="ref-vol">303</span>:701.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/7402257" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7402257</span></a>]<div>
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<i>(53 year old woman with alcoholic liver disease developed fever 10 days after starting triamterene and hydrochlorothiazide, resolving within 3 days of stopping and recurring twice with rechallenge using triamterene alone; no evidence of worsening of liver test abnormalities).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.nolan.1987.262">Nolan PJ, D’Arcy G. Triamterene drug fever and hepatitis. <span><span class="ref-journal">Med J Aust. </span>1987;<span class="ref-vol">147</span>:262.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/3670184" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3670184</span></a>]<div>
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<i>(44 year old woman developed fever, abdominal pain and anorexia ~3 weeks after starting triamterene [AST 428 U/L, Alk P 170 U/L, bilirubin not mentioned], resolving within days upon withdrawal with abrupt recurrence with eosinophilia upon restarting: Case 1, triamterene).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.russo.2004.1018">Russo MW, Galanko JA, Shrestha R, Fried MW, Watkins P. Liver transplantation for acute liver failure from drug-induced liver injury in the United States. <span><span class="ref-journal">Liver Transpl. </span>2004;<span class="ref-vol">10</span>:1018–23.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15390328" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15390328</span></a>]<div>
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<i>(Among ~50,000 liver transplants reported to UNOS between 1990 and 2002, 137 [0.5%] were done for idiosyncratic drug induced acute liver failure, none were attributed to a diuretic).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.andrade.2005.512">Andrade RJ, Lucena MI, Fernández MC, Pelaez G, Pachkoria K, García-Ruiz E, García-Muñoz B, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish Registry over a 10-year period. <span><span class="ref-journal">Gastroenterology. </span>2005;<span class="ref-vol">129</span>:512–21.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16083708" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16083708</span></a>]<div>
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<i>(Reports of drug induced liver injury to a Spanish network found 570 cases; diuretics not mentioned as cause).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.bj_rnsson.2006.33">Björnsson E, Olsson R. Suspected drug-induced liver fatalities reported to the WHO database. <span><span class="ref-journal">Dig Liver Dis. </span>2006;<span class="ref-vol">38</span>:33–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16054882" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16054882</span></a>]<div>
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<i>(Survey of drug induced liver fatalities reported to WHO database between 1968-2003 revealed 4690 reports [89% from the US]; no diuretic found in the 20 most commonly implicated agents).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.sabat_.2007.1401">Sabaté M, Ibáñez L, Pérez E, Vidal X, Buti M, Xiol X, Mas A, et al. Risk of acute liver injury associated with the use of drugs: a multicentre population survey. <span><span class="ref-journal">Aliment Pharmacol Ther. </span>2007;<span class="ref-vol">25</span>:1401–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17539979" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17539979</span></a>]<div>
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<i>(Population based survey of 126 cases of acute liver injury [24 with acute liver failure] due to drugs between 1993-1999 in Spain calculated relative risk of injury compared to the general population: hydrochlorothiazide was being taken by 7 and furosemide by 8 patients, but relative risk was not increased in comparison to a control group).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.chalasani.2008.1924">Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J., Drug Induced Liver Injury Network (DILIN). Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. <span><span class="ref-journal">Gastroenterology. </span>2008;<span class="ref-vol">135</span>:1924–34.</span> [<a href="/pmc/articles/PMC3654244/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3654244</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18955056" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18955056</span></a>]<div>
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<i>(Among 300 cases of drug induced liver disease in the US collected between 2004 and 2008, no case was attributed to a diuretic).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF12">Drugs for hypertension. <span><span class="ref-journal">Treat Guidel Med Lett. </span>2009;<span class="ref-vol">7</span>:1–10.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19107095" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19107095</span></a>]<div>
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<i>(Brief overview of currently available drugs for hypertension with guidelines on their use and information on prices and toxicities: “thiazide diuretics are the first-line therapy for many patients with hypertension”).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.devarbhavi.2010.2396">Devarbhavi H, Dierkhising R, Kremers WK, Sandeep MS, Karanth D, Adarsh CK. Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality. <span><span class="ref-journal">Am J Gastroenterol. </span>2010;<span class="ref-vol">105</span>:2396–404.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/20648003" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20648003</span></a>]<div>
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<i>(Among 313 cases of drug induced liver injury seen over a 12 year period at a large hospital in Bangalore, India, none were attributed to a diuretic).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.ferrajolo.2010.721">Ferrajolo C, Capuano A, Verhamme KM, Schuemie M, Rossi F, Stricker BH, Sturkenboom MC. Drug-induced hepatic injury in children: a case/non-case study of suspected adverse drug reactions in VigiBase. <span><span class="ref-journal">Br J Clin Pharmacol. </span>2010;<span class="ref-vol">70</span>:721–8.</span> [<a href="/pmc/articles/PMC2997312/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2997312</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/21039766" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21039766</span></a>]<div>
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<i>(Among 624,673 adverse event reports in children between 2000 and 2006 in the WHO VigiBase, no diuretic was mentioned among the 30 most common causes of liver injury).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.reuben.2010.2065">Reuben A, Koch DG, Lee WM., Acute Liver Failure Study Group. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. <span><span class="ref-journal">Hepatology. </span>2010;<span class="ref-vol">52</span>:2065–76.</span> [<a href="/pmc/articles/PMC3992250/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3992250</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20949552" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20949552</span></a>]<div>
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<i>(Among 1198 patients with acute liver failure enrolled in a US prospective study between 1998 and 2007, 133 were attributed to drug induced liver injury, of which none were attributed to a diuretic).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.bj_rnsson.2013.1419">Björnsson ES, Bergmann OM, Björnsson HK, Kvaran RB, Olafsson S. Incidence, presentation and outcomes in patients with drug-induced liver injury in the general population of Iceland. <span><span class="ref-journal">Gastroenterology. </span>2013;<span class="ref-vol">144</span>:1419–25.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/23419359" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23419359</span></a>]<div>
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<i>(In a population based study of drug induced liver injury from Iceland, 96 cases were identified over a 2 year period, none of which were attributed to a diuretic).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.hern_ndez.2014.231">Hernández N, Bessone F, Sánchez A, di Pace M, Brahm J, Zapata R, A, Chirino R, et al. Profile of idiosyncratic drug induced liver injury in Latin America: an analysis of published reports. <span><span class="ref-journal">Ann Hepatol. </span>2014;<span class="ref-vol">13</span>:231–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24552865" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24552865</span></a>]<div>
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<i>(Among 176 reports of drug induced liver injury from Latin America published between 1996 and 2012, none were attributed to a diuretic).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF.chalasani.2015.1340">Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, Talwalkar J, Reddy KR, et al. United States Drug Induced Liver Injury Network. Features and outcomes of 899 patients with drug-induced liver injury: The DILIN Prospective Study. <span><span class="ref-journal">Gastroenterology. </span>2015;<span class="ref-vol">148</span>:1340–52.e7.</span> [<a href="/pmc/articles/PMC4446235/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4446235</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25754159" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25754159</span></a>]<div>
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<i>(Among 899 cases of drug induced liver injury enrolled in a US prospective study between 2004 and 2013, none were attributed to a diuretic).</i>
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</div></div></li><li><div class="bk_ref" id="Triamterene.REF19">Drugs for hypertension. <span><span class="ref-journal">Med Lett Drugs Ther. </span>2020;<span class="ref-vol">62</span>(1598):73–80.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/32555118" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 32555118</span></a>]<div>
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<i>(Concise summary of efficacy, safety and costs of drug therapy of hypertension including the diuretics, focusing upon relative usefulness; no mention of hepatic adverse events).</i>
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</div></div></li></ul></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK547859_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Update: <span itemprop="dateModified">October 13, 2021</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="https://www.niddk.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Diabetes and Digestive and Kidney Diseases</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Triamterene. [Updated 2021 Oct 13].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/livertox/Tremelimumab/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/livertox/Triazolam/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobTriamtereneTc"><div id="Triamterene.Tc" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK547859/table/Triamterene.Tc/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Triamterene.Tc_lrgtbl__"><table><tbody><tr><th id="hd_b_Triamterene.Tc_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Medication:</th><td headers="hd_b_Triamterene.Tc_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Triamterene (100 mg daily)</td></tr><tr><th id="hd_b_Triamterene.Tc_1_1_2_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Pattern:</th><td headers="hd_b_Triamterene.Tc_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hepatocellular (R=6.8)</td></tr><tr><th id="hd_b_Triamterene.Tc_1_1_3_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Severity:</th><td headers="hd_b_Triamterene.Tc_1_1_3_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mild (enzyme elevations without jaundice)</td></tr><tr><th id="hd_b_Triamterene.Tc_1_1_4_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Latency:</th><td headers="hd_b_Triamterene.Tc_1_1_4_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1 month initially, 1 day on rechallenge</td></tr><tr><th id="hd_b_Triamterene.Tc_1_1_5_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Recovery:</th><td headers="hd_b_Triamterene.Tc_1_1_5_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">1-2 weeks</td></tr><tr><th id="hd_b_Triamterene.Tc_1_1_6_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Other medications:</th><td headers="hd_b_Triamterene.Tc_1_1_6_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">None</td></tr></tbody></table></div></div></article><article data-type="table-wrap" id="figobTriamtereneTd"><div id="Triamterene.Td" class="table"><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK547859/table/Triamterene.Td/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__Triamterene.Td_lrgtbl__"><table><thead><tr><th id="hd_h_Triamterene.Td_1_1_1_1" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DRUG</th><th id="hd_h_Triamterene.Td_1_1_1_2" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CAS REGISTRY NUMBER</th><th id="hd_h_Triamterene.Td_1_1_1_3" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MOLECULAR FORMULA</th><th id="hd_h_Triamterene.Td_1_1_1_4" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">STRUCTURE</th></tr></thead><tbody><tr><td headers="hd_h_Triamterene.Td_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Triamterene</td><td headers="hd_h_Triamterene.Td_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134973115" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem">396-01-0</a>
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</td><td headers="hd_h_Triamterene.Td_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">C12-H11-N7</td><td headers="hd_h_Triamterene.Td_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<a href="https://pubchem.ncbi.nlm.nih.gov/substance/134973115" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134973115" alt="image 134973115 in the ncbi pubchem database" /></a>
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