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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="PDQ Cancer Information Summaries [Internet]" /><meta name="citation_title" content="Childhood Pleuropulmonary Blastoma Treatment (PDQ®)" /><meta name="citation_publisher" content="National Cancer Institute (US)" /><meta name="citation_date" content="2019/10/02" /><meta name="citation_author" content="PDQ Pediatric Treatment Editorial Board" /><meta name="citation_pmid" content="31593389" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK547389/" /><meta name="citation_keywords" content="pleuropulmonary blastoma" /><meta name="citation_keywords" content="childhood pleuropulmonary blastoma" /><meta name="citation_keywords" content="childhood lung cancer" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Childhood Pleuropulmonary Blastoma Treatment (PDQ®)" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Cancer Institute (US)" /><meta name="DC.Contributor" content="PDQ Pediatric Treatment Editorial Board" /><meta name="DC.Date" content="2019/10/02" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK547389/" /><meta name="description" content="Surgery and chemotherapy are used to treat pleuropulmonary blastoma. Learn more about the risk factors, symptoms, tests to diagnose, and treatment of pleuropulmonary blastoma in this expert-reviewed summary." /><meta name="og:title" content="Childhood Pleuropulmonary Blastoma Treatment (PDQ®)" /><meta name="og:type" content="book" /><meta name="og:description" content="Surgery and chemotherapy are used to treat pleuropulmonary blastoma. Learn more about the risk factors, symptoms, tests to diagnose, and treatment of pleuropulmonary blastoma in this expert-reviewed summary." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK547389/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/pdqcis/CDR0000790954/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK547389/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/pdqcis/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" alt="Cover of PDQ Cancer Information Summaries" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>PDQ Cancer Information Summaries [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK547389_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK547389_dtls__"><div>Bethesda (MD): <a href="http://www.cancer.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Cancer Institute (US)</a>; 2002-.</div></div><div class="half_rhythm"></div><div class="bk_noprnt"><form method="get" action="/books/n/pdqcis/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK547389_"><span class="title" itemprop="name">Childhood Pleuropulmonary Blastoma Treatment (PDQ®)</span></h1><div class="subtitle whole_rhythm">Patient Version</div><p class="contrib-group"><span itemprop="author">PDQ Pediatric Treatment Editorial Board</span>.</p><p class="small">Published online: August 20, 2020.</p><p class="small">Created: <span itemprop="datePublished">October 2, 2019</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><p id="CDR0000790954__1">This PDQ cancer information summary has current information about the treatment of a type of childhood lung cancer called pleuropulmonary blastoma. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p><p id="CDR0000790954__2">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change. The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Pediatric Treatment Editorial Board.</p></div><div id="CDR0000790954__1650"><h2 id="_CDR0000790954__1650_">General Information About Pleuropulmonary Blastoma Treatment</h2><div id="CDR0000790954__1650.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000790954__1651">Pleuropulmonary blastoma is a type of childhood lung cancer that forms in the tissues of the lung and pleura or the organs between the lungs. </a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1655">There are three types of pleuropulmonary blastoma.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1659">Having a certain change in the <i>DICER1</i> gene increases the risk of pleuropulmonary blastoma.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1664">Signs and symptoms of pleuropulmonary blastoma include trouble breathing and lung infections.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1669">Tests that examine the chest are used to help diagnose pleuropulmonary blastoma.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1673">Certain factors affect prognosis (chance of recovery).</a></div></li></ul></div><div id="CDR0000790954__1651"><h3>Pleuropulmonary blastoma is a type of childhood lung cancer that forms in the tissues of the lung and pleura or the organs between the lungs. </h3><p id="CDR0000790954__1653"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000446557/" class="def">Pleuropulmonary blastomas</a> form in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a> of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270740/" class="def">lung</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045842/" class="def">pleura</a> (tissue that covers the lungs and lines the inside of the chest). They can also form in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000257523/" class="def">organs</a> between the lungs including the heart, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044527/" class="def">aorta</a>, and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045852/" class="def">pulmonary</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000440100/" class="def">artery</a>, or in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046451/" class="def">diaphragm</a> (the main breathing muscle below the lungs).</p><p id="CDR0000790954__1654"> In most cases, pleuropulmonary blastomas are linked to a certain change in the <i>DICER1</i>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045693/" class="def">gene</a>.</p></div><div id="CDR0000790954__1655"><h3>There are three types of pleuropulmonary blastoma.</h3><p id="CDR0000790954__1657">The types of pleuropulmonary blastoma include the following:</p><ul id="CDR0000790954__1658"><li class="half_rhythm"><div>Type I <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumors</a> are <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046461/" class="def">cyst</a>-like tumors in the lung. They are most common in children aged 2 years and younger and have a good chance of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454708/" class="def">recovery</a>. Type Ir tumors are Type I tumors that have <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046039/" class="def">regressed</a> (gotten smaller) or have not grown or spread. After treatment, a Type I tumor may <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recur</a> as a Type II or III tumor.</div></li><li class="half_rhythm"><div>Type II tumors are cyst-like with some solid parts. These tumors sometimes spread to the brain or other parts of the body.</div></li><li class="half_rhythm"><div>Type III tumors are solid tumors. These tumors often spread to the brain or other parts of the body.</div></li></ul></div><div id="CDR0000790954__1659"><h3>Having a certain change in the <i>DICER1</i> gene increases the risk of pleuropulmonary blastoma.</h3><p id="CDR0000790954__1661">Anything that increases your chance of getting a disease is called a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045873/" class="def">risk factor</a>. Having a risk factor does not mean that you will get <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>; not having risk factors doesn't mean that you will not get cancer. Talk with your child's doctor if you think your child may be at risk.</p><p id="CDR0000790954__1662">Risk factors for pleuropulmonary blastoma include the following:</p><ul id="CDR0000790954__1663"><li class="half_rhythm"><div>Having a certain change in the <i>DICER1</i> gene.</div></li><li class="half_rhythm"><div>Having a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000302456/" class="def">family history</a> of DICER1 syndrome.</div></li></ul></div><div id="CDR0000790954__1664"><h3>Signs and symptoms of pleuropulmonary blastoma include trouble breathing and lung infections.</h3><p id="CDR0000790954__1666">These and other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000750109/" class="def">signs</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045022/" class="def">symptoms</a> may be caused by pleuropulmonary blastoma or by other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">conditions</a>.</p><p id="CDR0000790954__1667">Check with your child's doctor if your child has any of the following:</p><ul id="CDR0000790954__1668"><li class="half_rhythm"><div>A cough that doesn’t go away.</div></li><li class="half_rhythm"><div>Trouble breathing.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000450108/" class="def">Fever</a>.</div></li><li class="half_rhythm"><div>Lung <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045364/" class="def">infections</a>, such as <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045476/" class="def">pneumonia</a>.</div></li><li class="half_rhythm"><div>Pain in the chest or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045070/" class="def">abdomen</a>.</div></li><li class="half_rhythm"><div>Loss of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454699/" class="def">appetite</a>.</div></li><li class="half_rhythm"><div>Weight loss for no known reason.</div></li></ul></div><div id="CDR0000790954__1669"><h3><div class="milestone-start" id="CDR0000790954__1670"></div>Tests that examine the chest are used to help diagnose pleuropulmonary blastoma.<div class="milestone-end"></div></h3><p id="CDR0000790954__1671">
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The following tests and procedures may be used:</p><ul id="CDR0000790954__1672"><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270871/" class="def">Physical exam</a> and health history</b>: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000304687/" class="def">Chest x-ray</a></b>: An <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045944/" class="def">x-ray</a> of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000257523/" class="def">organs</a> and bones inside the chest. An x-ray is a type of energy beam that can go through the body and onto film, making a picture of areas inside the body.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046033/" class="def">CT scan</a> (CAT scan)</b>: A procedure that makes a series of detailed pictures of areas inside the body, such as the chest and abdomen, taken from different angles. The pictures are made by a computer linked to an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045944/" class="def">x-ray</a> machine. A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000409764/" class="def">dye</a> may be <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044678/" class="def">injected</a> into a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476471/" class="def">vein</a> or swallowed to help the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000257523/" class="def">organs</a> or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissues</a> show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.<div id="CDR0000790954__1732" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Computed%20tomography%20(CT)%20scan%20of%20the%20abdomen&p=BOOKS&id=561185_CDR0000775531.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK547389.3/bin/CDR0000775531.jpg" alt="Computed tomography (CT) scan of the abdomen; drawing shows a child lying on a table that slides through the CT scanner, which takes x-ray pictures of the inside of the abdomen." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Computed tomography (CT) scan of the abdomen. The child lies on a table that slides through the CT scanner, which takes x-ray pictures of the inside of the abdomen.</p></div></div></div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046140/" class="def">PET scan</a> (positron emission tomography scan)</b>: A procedure to find <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045772/" class="def">malignant</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> in the body. A small amount of radioactive glucose (sugar) is injected into a vein. The PET <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000386220/" class="def">scanner</a> rotates around the body and makes a picture of where <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044033/" class="def">glucose</a> is being used in the body. Malignant tumor cells show up brighter in the picture because they are more active and take up more glucose than normal cells do.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045788/" class="def">MRI</a> (magnetic resonance imaging)</b>: A procedure that uses a magnet, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651209/" class="def">radio waves</a>, and a computer to make a series of detailed pictures of areas of the body, such as the head. This procedure is also called nuclear magnetic resonance imaging (NMRI).</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046499/" class="def">Bone scan</a></b>: A procedure to check if there are rapidly dividing cells, such as cancer cells, in the bone. A very small amount of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046550/" class="def">radioactive</a> material is injected into a vein and travels through the bloodstream. The radioactive material collects in the bones with cancer and is detected by a scanner.<div id="CDR0000790954__1649" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Bone%20scan&p=BOOKS&id=561185_CDR0000775451.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK547389.3/bin/CDR0000775451.jpg" alt="Bone scan; drawing shows a child lying on a table that slides under the scanner, a technician operating the scanner, and a computer monitor that will show images made during the scan." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Bone scan. A small amount of radioactive material is injected into the child's vein and travels through the blood. The radioactive material collects in the bones. As the child lies on a table that slides under the scanner, the radioactive material is detected and images are made on a computer screen.</p></div></div></div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045628/" class="def">Bronchoscopy</a></b>: A procedure to look inside the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046623/" class="def">trachea</a> and large airways in the lung for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044636/" class="def">abnormal</a> areas. A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046496/" class="def">bronchoscope</a> is inserted through the nose or mouth into the trachea and lungs. A bronchoscope is a thin, tube-like instrument with a light and a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000572035/" class="def">lens</a> for viewing. It may also have a tool to remove tissue samples, which are checked under a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000638184/" class="def">microscope</a> for signs of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>.</div></li><li class="half_rhythm"><div><b><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046119/" class="def">Thoracoscopy</a></b>: A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgical</a> procedure to look at the organs inside the chest to check for abnormal areas. An <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046353/" class="def">incision</a> (cut) is made between two ribs, and a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476929/" class="def">thoracoscope</a> is inserted into the chest. A thoracoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045762/" class="def">lymph node</a> samples, which are checked under a microscope for signs of cancer. In some cases, this procedure is used to remove part of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046408/" class="def">esophagus</a> or lung. If the thoracoscope cannot reach certain tissues, organs, or lymph nodes, a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045926/" class="def">thoracotomy</a> may be done. In this procedure, a larger incision is made between the ribs and the chest is opened.</div></li></ul></div><div id="CDR0000790954__1673"><h3>Certain factors affect prognosis (chance of recovery).</h3><p id="CDR0000790954__1675"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045849/" class="def">Prognosis</a> depends on:</p><ul id="CDR0000790954__1676"><li class="half_rhythm"><div>The type of pleuropulmonary blastoma.</div></li><li class="half_rhythm"><div>Whether the cancer has spread to other parts of the body at the time of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnosis</a>.</div></li><li class="half_rhythm"><div>Whether the cancer was completely removed by <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">surgery</a>.</div></li></ul></div></div><div id="CDR0000790954__1677"><h2 id="_CDR0000790954__1677_">Stages of Pleuropulmonary Blastoma</h2><div id="CDR0000790954__1677.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000790954__1678">After pleuropulmonary blastoma has been diagnosed, tests are done to find out if cancer cells have spread to nearby areas or to other parts of the body.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1681">There are three ways that cancer spreads in the body.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1683">Cancer may spread from where it began to other parts of the body.</a></div></li></ul></div><div id="CDR0000790954__1678"><h3>After pleuropulmonary blastoma has been diagnosed, tests are done to find out if cancer cells have spread to nearby areas or to other parts of the body.</h3><p id="CDR0000790954__1680">The process used to find out if <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000446557/" class="def">pleuropulmonary blastoma</a> has spread to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissues</a> in the chest or to other parts of the body is called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046597/" class="def">staging</a>. The information gathered from the staging process is used to plan treatment. The results of the <a href="#CDR0000790954__1670">tests and procedures</a> used to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnose</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> are often also used to stage the disease. </p><p id="CDR0000790954__1736">Sometimes childhood pleuropulmonary blastoma <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurs</a> (comes back) after treatment.</p></div><div id="CDR0000790954__1681"><h3>There are three ways that cancer spreads in the body.</h3><p id="CDR0000790954__1681_69">Cancer can spread through <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a>, the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045764/" class="def">lymph system</a>, and the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270735/" class="def">blood</a>:</p><ul id="CDR0000790954__1681_70"><li class="half_rhythm"><div>Tissue. The cancer spreads from where it began by growing into nearby areas.
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</div></li><li class="half_rhythm"><div>Lymph system. The cancer spreads from where it began by getting into the lymph system. The cancer travels through the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000269462/" class="def">lymph vessels</a> to other parts of the body.
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</div></li><li class="half_rhythm"><div>Blood. The cancer spreads from where it began by getting into the blood. The cancer travels through the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045020/" class="def">blood vessels</a> to other parts of the body.
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</div></li></ul></div><div id="CDR0000790954__1683"><h3>Cancer may spread from where it began to other parts of the body.</h3><p id="CDR0000790954__1683_66">When cancer spreads to another part of the body, it is called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046710/" class="def">metastasis</a>. Cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> break away from where they began (the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045847/" class="def">primary tumor</a>) and travel through the lymph system or blood.</p><ul id="CDR0000790954__1683_67"><li class="half_rhythm"><div>Lymph system. The cancer gets into the lymph system, travels through the lymph vessels, and forms a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044058/" class="def">metastatic</a> tumor) in another part of the body.</div></li><li class="half_rhythm"><div>Blood. The cancer gets into the blood, travels through the blood vessels, and forms a tumor (metastatic tumor) in another part of the body.</div></li></ul><p id="CDR0000790954__1685">The <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044058/" class="def">metastatic</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> is the same type of cancer as the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045847/" class="def">primary tumor</a>. For example, if pleuropulmonary blastoma spreads to the brain, the cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> in the brain are actually pleuropulmonary blastoma cells. The disease is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044058/" class="def">metastatic</a> pleuropulmonary blastoma, not brain cancer.</p><div id="CDR0000790954__1733" class="box"><h3><span class="title">metastasis: how cancer spreads</span></h3><div class="caption"><p>Many cancer deaths are caused when cancer moves from the original tumor and spreads to other tissues and organs. This is called metastatic cancer. This animation shows how cancer cells travel from the place in the body where they first formed to other parts of the body.</p></div><p><a href="https://www.youtube.com/watch?v=fQwar_-QdiQ" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">YouTube</a></p></div></div></div><div id="CDR0000790954__1688"><h2 id="_CDR0000790954__1688_">Treatment Option Overview</h2><div id="CDR0000790954__1688.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000790954__1689">There are different types of treatment for children with pleuropulmonary blastoma.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1691">Children with pleuropulmonary blastoma should have their treatment planned by a team of doctors who are experts in treating childhood cancer.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1695">Two types of standard treatment are used for pleuropulmonary blastoma:</a></div><ul><li class="half_rhythm"><div><a href="#CDR0000790954__1697">Surgery</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1700">Chemotherapy</a></div></li></ul></li><li class="half_rhythm"><div><a href="#CDR0000790954__1703">New types of treatment are being tested in clinical trials.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1710">Treatment for pleuropulmonary blastoma may cause side effects.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1715">Patients may want to think about taking part in a clinical trial.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1717">Patients can enter clinical trials before, during, or after starting their cancer treatment.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000790954__1719">Follow-up tests may be needed.</a></div></li></ul></div><div id="CDR0000790954__1689"><h3>There are different types of treatment for children with pleuropulmonary blastoma.</h3><p id="CDR0000790954__1689_79">Some treatments are <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044930/" class="def">standard</a> (the currently used treatment), and some are being tested in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a>. A treatment clinical trial is a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651211/" class="def">research study</a> meant to help improve current treatments or obtain information on new treatments for patients with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.</p><p id="CDR0000790954__1689_80">Because cancer in children is rare, taking part in a clinical trial should be considered. Some clinical trials are open only to patients who have not started treatment.</p></div><div id="CDR0000790954__1691"><h3>Children with pleuropulmonary blastoma should have their treatment planned by a team of doctors who are experts in treating childhood cancer.</h3><p id="CDR0000790954__1693">Treatment will be overseen by a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000693555/" class="def">pediatric oncologist</a>, a doctor who specializes in treating children with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a>. The pediatric oncologist works with other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046245/" class="def">pediatric</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000650566/" class="def">health professionals</a> who are experts in treating children with cancer and who specialize in certain areas of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000482419/" class="def">medicine</a>. This may include the following <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000478785/" class="def">specialists</a> and others:</p><ul id="CDR0000790954__1694"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000757278/" class="def">Pediatrician</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000318823/" class="def">Pediatric surgeon</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046244/" class="def">Pathologist</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000318821/" class="def">Pediatric nurse specialist</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044730/" class="def">Social worker</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000318825/" class="def">Rehabilitation specialist</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044716/" class="def">Psychologist</a>.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000690737/" class="def">Child-life specialist</a>.</div></li></ul></div><div id="CDR0000790954__1695"><h3><div class="milestone-start" id="CDR0000790954__1696"></div>Two types of standard treatment are used for pleuropulmonary blastoma:<div class="milestone-end"></div></h3><div id="CDR0000790954__1697"><h4>Surgery</h4><p id="CDR0000790954__1699"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">Surgery</a> to remove the whole <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046188/" class="def">lobe</a> of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270740/" class="def">lung</a> with cancer is used to treat <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000446557/" class="def">pleuropulmonary blastoma</a>.</p><div id="CDR0000790954__1735" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Lobectomy&p=BOOKS&id=561185_CDR0000466538.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK547389.3/bin/CDR0000466538.jpg" alt="Lobectomy; drawing shows lobes of both lungs, trachea, bronchi, bronchioles, and lymph nodes. Cancer is shown in one lobe. The removed lobe is shown next to the lung from which it was removed." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Lobectomy. A lobe of the lung is removed.</p></div></div><p id="CDR0000790954__1734"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">Chemotherapy</a> may be given before surgery to remove the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a>. When given before surgery, chemotherapy will shrink the tumor and reduce the amount of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046683/" class="def">tissue</a> that needs to be removed during surgery. Treatment given before surgery is called preoperative therapy or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045800/" class="def">neoadjuvant therapy</a>.</p></div><div id="CDR0000790954__1700"><h4>Chemotherapy</h4><p id="CDR0000790954__1702">Chemotherapy is a cancer treatment that uses <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000348921/" class="def">drugs</a> to stop the growth of cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a>, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044678/" class="def">injected</a> into a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000476471/" class="def">vein</a> or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000301626/" class="def">systemic chemotherapy</a>).</p></div></div><div id="CDR0000790954__1703"><h3>New types of treatment are being tested in clinical trials.</h3><p id="CDR0000790954__1705">This summary section describes treatments that are being studied in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a>. It may not mention every new treatment being studied. Information about clinical trials is available from the <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCI website</a>.</p><div id="CDR0000790954__1706"><h4>Targeted therapy</h4><p id="CDR0000790954__1708"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270742/" class="def">Targeted therapy</a> is a type of treatment that uses drugs or other substances to attack cancer cells. Targeted therapies usually cause less harm to normal cells than chemotherapy or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044971/" class="def">radiation therapy</a> do.</p><p id="CDR0000790954__1709">Targeted therapy is being studied for the treatment of pleuropulmonary blastoma that has <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurred</a> (come back).</p></div></div><div id="CDR0000790954__1710"><h3>Treatment for pleuropulmonary blastoma may cause side effects.</h3><p id="CDR0000790954__1710_76">For information about <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> that begin during treatment for cancer, see our <a href="https://www.cancer.gov/about-cancer/treatment/side-effects" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Side Effects</a> page.</p><p id="CDR0000790954__1712">Side effects from cancer treatment that begin after treatment and continue for months or years are called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390292/" class="def">late effects</a>. Late effects of cancer treatment may include:</p><ul id="CDR0000790954__1713"><li class="half_rhythm"><div>Physical problems.</div></li><li class="half_rhythm"><div>Changes in mood, feelings, thinking, learning, or memory.</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046658/" class="def">Second cancers</a> (new types of cancer) or other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">conditions</a>.</div></li></ul><p id="CDR0000790954__1714">Some late effects may be treated or controlled. It is important to talk with your child's doctors about the possible late effects caused by some treatments.</p></div><div id="CDR0000790954__1715"><h3>Patients may want to think about taking part in a clinical trial.</h3><p id="CDR0000790954__1715_23">For some patients, taking part in a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trial</a> may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044930/" class="def">standard treatment</a>.</p><p id="CDR0000790954__1715_24">Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.</p><p id="CDR0000790954__1715_25">Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.</p></div><div id="CDR0000790954__1717"><h3>Patients can enter clinical trials before, during, or after starting their cancer treatment.</h3><p id="CDR0000790954__1717_29">Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurring</a> (coming back) or reduce the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046580/" class="def">side effects</a> of cancer treatment.</p><p id="CDR0000790954__1717_30">Clinical trials are taking place in many parts of the country. Information about clinical trials supported by NCI can be found on NCI’s <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trials search</a> webpage. Clinical trials supported by other organizations can be found on the <a href="https://clinicaltrials.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ClinicalTrials.gov</a> website.</p></div><div id="CDR0000790954__1719"><h3>Follow-up tests may be needed.</h3><p id="CDR0000790954__1719_55">Some of the tests that were done to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnose</a> the cancer or to find out the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045885/" class="def">stage</a> of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.</p><p id="CDR0000790954__1719_56">Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your child's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000651193/" class="def">condition</a> has changed or if the cancer has <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recurred</a> (come back). These tests are sometimes called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044671/" class="def">follow-up</a> tests or check-ups.</p></div></div><div id="CDR0000790954__1721"><h2 id="_CDR0000790954__1721_">Treatment of Pleuropulmonary Blastoma</h2><p id="CDR0000790954__1722">For information about the treatments listed below, see the <a href="#CDR0000790954__1696">Treatment Option Overview</a> section.</p><p id="CDR0000790954__1723">Treatment of newly <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046450/" class="def">diagnosed</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000446557/" class="def">pleuropulmonary blastoma</a> may include the following:</p><ul id="CDR0000790954__1724"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045570/" class="def">Surgery</a> to remove the whole <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046188/" class="def">lobe</a> of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270740/" class="def">lung</a> the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> is in, for Type I and Type Ir pleuropulmonary blastoma.</div></li><li class="half_rhythm"><div>Surgery to remove the whole lobe of the lung the cancer is in, with or without <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045214/" class="def">chemotherapy</a>, for Type II and Type III pleuropulmonary blastoma.</div></li></ul><p id="CDR0000790954__TrialSearch_1721_19">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div><div id="CDR0000790954__1725"><h2 id="_CDR0000790954__1725_">Treatment of Recurrent Pleuropulmonary Blastoma</h2><p id="CDR0000790954__1726">For information about the treatments listed below, see the <a href="#CDR0000790954__1696">Treatment Option Overview</a> section.</p><p id="CDR0000790954__1727">Treatment of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045862/" class="def">recurrent</a>
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<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000446557/" class="def">pleuropulmonary blastoma</a> in children may include the following:</p><ul id="CDR0000790954__1728"><li class="half_rhythm"><div>A <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trial</a> that checks a sample of the patient's <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumor</a> for certain <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045693/" class="def">gene</a> changes. The type of <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000270742/" class="def">targeted therapy</a> that will be given to the patient depends on the type of gene change.</div></li></ul></div><div id="CDR0000790954__1729"><h2 id="_CDR0000790954__1729_">To Learn More About Pleuropulmonary Blastoma</h2><p id="CDR0000790954__1730">For more information from the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044266/" class="def">National Cancer Institute</a> about pleuropulmonary blastoma, see the following:</p><ul id="CDR0000790954__1731"><li class="half_rhythm"><div><a href="https://www.cancer.gov/types/lung" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Lung Cancer Home Page</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/diagnosis-staging/ct-scans-fact-sheet" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Computed Tomography (CT) Scans and Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Targeted Cancer Therapies</a></div></li></ul><p id="CDR0000790954__1729_44">For more childhood <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045333/" class="def">cancer</a> information and other general cancer resources, see the following:</p><ul id="CDR0000790954__1729_45"><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">About Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/types/childhood-cancers" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Childhood Cancers</a>
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</div></li><li class="half_rhythm"><div><a href="http://www.curesearch.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">CureSearch for Children's Cancer</a>
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</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/CDR0000373791/">Late Effects of Treatment for Childhood Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/types/aya" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Adolescents and Young Adults with Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/publications/patient-education/guide-for-parents" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Children with Cancer: A Guide for Parents</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/types/childhood-cancers/child-adolescent-cancers-fact-sheet" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cancer in Children and Adolescents</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/diagnosis-staging/staging" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Staging</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/coping" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Coping with Cancer</a></div></li><li class="half_rhythm"><div><a href="https://www.cancer.gov/about-cancer/coping/questions" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Questions to Ask Your Doctor about Cancer</a></div></li><li class="half_rhythm"><div><a href="https://cancercontrol.cancer.gov/ocs/resources/survivors.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">For Survivors and Caregivers</a>
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</div></li></ul></div><div id="CDR0000790954__AboutThis_1"><h2 id="_CDR0000790954__AboutThis_1_">About This PDQ Summary</h2><div id="CDR0000790954__AboutThis_2"><h3>About PDQ</h3><p id="CDR0000790954__AboutThis_3">Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in <a href="https://www.cancer.gov/espanol/publicaciones/pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Spanish</a>.</p><p id="CDR0000790954__AboutThis_4">PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.</p></div><div id="CDR0000790954__AboutThis_5"><h3>Purpose of This Summary</h3><p id="CDR0000790954__AboutThis_6">This PDQ cancer information summary has current information about the treatment of childhood pleuropulmonary blastoma. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p></div><div id="CDR0000790954__AboutThis_7"><h3>Reviewers and Updates</h3><p id="CDR0000790954__AboutThis_8">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change.
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</p><p id="CDR0000790954__AboutThis_9">The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the <a href="https://www.cancer.gov/publications/pdq/editorial-boards/pediatric-treatment" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PDQ Pediatric Treatment Editorial Board</a>.
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</p></div><div id="CDR0000790954__AboutThis_10"><h3>Clinical Trial Information</h3><p id="CDR0000790954__AboutThis_11">A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
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</p><p id="CDR0000790954__AboutThis_12">Clinical trials can be found online at <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCI's website</a>. For more information, call the <a href="https://www.cancer.gov/contact/contact-center" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cancer Information Service</a> (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237).
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</p></div><div id="CDR0000790954__AboutThis_13"><h3>Permission to Use This Summary</h3><p id="CDR0000790954__AboutThis_14">PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”
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</p><p id="CDR0000790954__AboutThis_15">The best way to cite this PDQ summary is:</p><p id="CDR0000790954__AboutThis_21">PDQ® Pediatric Treatment Editorial Board. PDQ Childhood Pleuropulmonary Blastoma Treatment. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: <a href="https://www.cancer.gov/types/lung/patient/child-pleuropulmonary-blastoma-treatment-pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www.cancer.gov/types/lung/patient/child-pleuropulmonary-blastoma-treatment-pdq</a>. Accessed <MM/DD/YYYY>. </p><p id="CDR0000790954__AboutThis_16">Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in <a href="https://visualsonline.cancer.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Visuals Online</a>. Visuals Online is a collection of more than 3,000 scientific images.
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</p></div><div id="CDR0000790954__AboutThis_17"><h3>Disclaimer</h3><p id="CDR0000790954__AboutThis_18">The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the <a href="https://www.cancer.gov/about-cancer/managing-care" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Managing Cancer Care</a> page.</p></div><div id="CDR0000790954__AboutThis_19"><h3>Contact Us</h3><p id="CDR0000790954__AboutThis_20">More information about contacting us or receiving help with the Cancer.gov website can be found on our <a href="https://www.cancer.gov/contact" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Contact Us for Help</a> page. Questions can also be submitted to Cancer.gov through the website’s <a href="https://www.cancer.gov/contact/email-us" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">E-mail Us</a>.</p></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK547389.3/?report=reader">PubReader</a></li><li><a href="/books/NBK547389.3/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK547389" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK547389" style="display:none" title="Cite this Page"><div class="bk_tt">PDQ Pediatric Treatment Editorial Board. Childhood Pleuropulmonary Blastoma Treatment (PDQ®): Patient Version. 2020 Aug 20. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. <span class="bk_cite_avail"></span></div></div></li><li><a href="#" class="toggle-glossary-link" title="Enable/disable links to the glossary">Disable Glossary Links</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Version History</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter shutter_closed" title="Show/hide content" remembercollapsed="true" pgsec_name="version_history" id="Shutter"></a></div><div class="portlet_content" style="display: none;"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><span class="bk_col_itm"><a href="/books/NBK547389.7/">NBK547389.7</a></span> October 17, 2024</li><li><span class="bk_col_itm"><a href="/books/NBK547389.6/">NBK547389.6</a></span> May 3, 2024</li><li><span class="bk_col_itm"><a href="/books/NBK547389.5/">NBK547389.5</a></span> April 26, 2024</li><li><span class="bk_col_itm"><a href="/books/NBK547389.4/">NBK547389.4</a></span> April 15, 2021</li><li><span class="bk_col_itm">NBK547389.3</span> August 20, 2020 (Displayed Version)</li><li><span class="bk_col_itm"><a href="/books/NBK547389.2/">NBK547389.2</a></span> February 20, 2020</li><li><span class="bk_col_itm"><a href="/books/NBK547389.1/">NBK547389.1</a></span> October 3, 2019</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this Page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#CDR0000790954__1650" ref="log$=inpage&link_id=inpage">General Information About Pleuropulmonary Blastoma Treatment</a></li><li><a href="#CDR0000790954__1677" ref="log$=inpage&link_id=inpage">Stages of Pleuropulmonary Blastoma</a></li><li><a href="#CDR0000790954__1688" ref="log$=inpage&link_id=inpage">Treatment Option Overview</a></li><li><a href="#CDR0000790954__1721" ref="log$=inpage&link_id=inpage">Treatment of Pleuropulmonary Blastoma</a></li><li><a href="#CDR0000790954__1725" ref="log$=inpage&link_id=inpage">Treatment of Recurrent Pleuropulmonary Blastoma</a></li><li><a href="#CDR0000790954__1729" ref="log$=inpage&link_id=inpage">To Learn More About Pleuropulmonary Blastoma</a></li><li><a href="#CDR0000790954__AboutThis_1" ref="log$=inpage&link_id=inpage">About This PDQ Summary</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related publications</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" id="Shutter"></a></div><div 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