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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/pdqcis/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-pdqcis-lrg.png" alt="Cover of PDQ Cancer Information Summaries" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>PDQ Cancer Information Summaries [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK545658_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK545658_dtls__"><div>Bethesda (MD): <a href="http://www.cancer.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Cancer Institute (US)</a>; 2002-.</div></div><div class="half_rhythm"></div><div class="bk_noprnt"><form method="get" action="/books/n/pdqcis/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK545658_"><span class="title" itemprop="name">Hereditary Kidney Cancer Syndromes (PDQ®)</span></h1><div class="subtitle whole_rhythm">Patient Version</div><p class="contrib-group"><span itemprop="author">PDQ Cancer Genetics Editorial Board</span>.</p><p class="small">Published online: June 6, 2024.</p><p class="small">Created: <span itemprop="datePublished">August 23, 2019</span>.</p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><p id="CDR0000797087__1">This PDQ cancer information summary has current information about the genetics of kidney cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p><p id="CDR0000797087__2">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change. The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Genetics Editorial Board.</p></div><div id="CDR0000797087__71"><h2 id="_CDR0000797087__71_">What is kidney cancer?</h2><div id="CDR0000797087__71.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000797087__72">Kidney cancer is a disease in which malignant (cancer) cells form in tubules of the kidney.</a></div></li></ul></div><div id="CDR0000797087__72"><h3>Kidney cancer is a disease in which malignant (cancer) cells form in tubules of the kidney.</h3><p id="CDR0000797087__74"><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000444995/" class="def">Kidney cancer</a> (also called renal cell cancer) is cancer that starts in the lining of very small tubes in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046325/" class="def">kidney</a> called renal tubules. There are two kidneys, one on each side of the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000415915/" class="def">backbone</a>, above the waist. Tubules in the kidneys filter and clean the blood. They take out waste products and make urine. The urine passes from each kidney through a long tube called a ureter into the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046501/" class="def">bladder</a>. The bladder holds the urine until it passes through the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046640/" class="def">urethra</a> and leaves the body.</p><div id="CDR0000797087__75" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Anatomy%20of%20the%20male%20urinary%20system%20(left%20panel)%20and%20female%20urinary%20system%20(right%20panel)%20showing%20the%20kidneys%2C%20ureters%2C%20bladder%2C%20and%20urethra&p=BOOKS&id=604227_CDR0000765031.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK545658.5/bin/CDR0000765031.jpg" alt="Anatomy of the male urinary system (left panel) and female urinary system (right panel); two-panel drawing showing the right and left kidneys, the ureters, the bladder filled with urine, and the urethra. The inside of the left kidney shows the renal pelvis. An inset shows the renal tubules and urine. Also shown are the prostate and penis (left panel) and the uterus (right panel)." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Anatomy of the male urinary system (left panel) and female urinary system (right panel) showing the kidneys, ureters, bladder, and urethra. The inside of the left kidney shows the renal pelvis. An inset shows the renal tubules and urine. Also shown are the prostate and penis (left panel) and the uterus (right panel). Urine is made in the renal tubules and collects in the renal pelvis of each kidney. The urine flows from the kidneys through the ureters to the bladder. The urine is stored in the bladder until it leaves the body through the urethra.</p></div></div><p id="CDR0000797087__76">Cancer that starts in the ureters or the renal pelvis (the part of the kidney that collects urine and drains it to the ureters) is called urothelial cancer. This kind of cancer is different from renal cell cancer and is not associated with the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000797792/" class="def">hereditary cancer syndromes</a> described in this summary. Urothelial cancer of the renal pelvis may be associated with another hereditary condition called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044882/" class="def">Lynch syndrome</a>. To learn more, see the health professional summary on <a href="/books/n/pdqcis/CDR0000062863/">Genetics of Colorectal Cancer</a>.</p></div></div><div id="CDR0000797087__77"><h2 id="_CDR0000797087__77_">What is hereditary kidney cancer?</h2><div id="CDR0000797087__77.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000797087__78">Having certain hereditary syndromes can increase the risk of kidney cancer.</a></div></li><li class="half_rhythm"><div><a href="#CDR0000797087__83">Hereditary and non-inherited kidney cancers differ in several ways.</a></div></li></ul></div><div id="CDR0000797087__78"><h3>Having certain hereditary syndromes can increase the risk of kidney cancer.</h3><p id="CDR0000797087__80">Most of the time, kidney cancer risk is not passed down from parent to child. Kidney cancer that affects multiple generations of a family is called hereditary kidney cancer. Hereditary kidney cancer accounts for only 5%‒8% of all kidney cancers. It is usually linked to a hereditary cancer syndrome. A hereditary cancer syndrome is a disorder in which family members have a higher-than-average risk of developing a certain type or types of cancer. Hereditary cancer syndromes are caused by inherited, harmful genetic changes (also called pathogenic variants or mutations) in certain genes. Hereditary cancer syndromes are sometimes called inherited cancer syndromes or family cancer syndromes. People with the hereditary cancer syndromes described in this summary have an increased risk of kidney cancer.</p><p id="CDR0000797087__81">The hereditary cancer syndromes described in this summary are:</p><ul id="CDR0000797087__82"><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000305992/" class="def">hereditary leiomyomatosis and renal cell cancer</a> (HLRCC)</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794341/" class="def">von Hippel-Lindau disease</a> (VHL)</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000256547/" class="def">Birt-Hogg-Dubé syndrome</a> (BHD)</div></li><li class="half_rhythm"><div><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000793854/" class="def">hereditary papillary renal cancer</a> (HPRC)</div></li></ul><p id="CDR0000797087__100">Every person inherits two copies of each gene, one from each parent. These syndromes occur when a person inherits a mutation in one copy of the gene associated with the syndrome. This form of inheritance is called autosomal dominant inheritance.</p><div id="CDR0000797087__101" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Autosomal%20dominant%20inheritance%20is%20a%20way%20a%20genetic%20trait%20or%20condition%20can%20be%20passed%20down%20from%20parent%20to%20child&p=BOOKS&id=604227_CDR0000793768.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK545658.5/bin/CDR0000793768.jpg" alt="Drawing showing an autosomal dominant inheritance pattern between a father, mother, and their four children: a chromosome pair with a normal gene and a mutated gene in an affected father; two normal genes in an unaffected mother; a normal gene and a mutated gene in an affected daughter and in an affected son; and two normal genes in an unaffected daughter and in an unaffected son." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Autosomal dominant inheritance is a way a genetic trait or condition can be passed down from parent to child. One copy of a mutated (changed) gene from one parent can cause the genetic condition. A child who has a parent with the mutated gene has a 50% chance of inheriting that mutated gene. Men and women are equally likely to have these mutations and sons and daughters are equally likely to inherit them.</p></div></div></div><div id="CDR0000797087__83"><h3>Hereditary and non-inherited kidney cancers differ in several ways.</h3><ul id="CDR0000797087__85"><li class="half_rhythm"><div>Hereditary kidney cancer is often diagnosed at an earlier age than <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000339347/" class="def">sporadic</a> kidney cancer.</div></li><li class="half_rhythm"><div>Some types of hereditary kidney cancer can be more or less <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046053/" class="def">aggressive</a> than sporadic kidney cancer.</div></li><li class="half_rhythm"><div>The treatments for hereditary kidney cancer may differ from treatments for sporadic kidney cancer.</div></li><li class="half_rhythm"><div>People with hereditary kidney cancer may have a higher risk of other conditions or types of cancer.</div></li></ul><p id="CDR0000797087__86">This page provides information about hereditary syndromes associated with kidney cancer. It does not cover information about sporadic kidney cancer or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046586/" class="def">somatic mutations</a> found during <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000768570/" class="def">tumor sequencing</a>.</p></div></div><div id="CDR0000797087__87"><h2 id="_CDR0000797087__87_">What is genetic counseling and who should receive it?</h2><div id="CDR0000797087__87.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000797087__88">Genetic counseling is a communication process between a specially trained health professional and a person concerned about the genetic risk of disease. </a></div></li><li class="half_rhythm"><div><a href="#CDR0000797087__92">Whether a person should get tested for hereditary kidney cancer depends on certain factors.</a></div></li></ul></div><div id="CDR0000797087__88"><h3>Genetic counseling is a communication process between a specially trained health professional and a person concerned about the genetic risk of disease. </h3><p id="CDR0000797087__91">It is not always easy to determine whether a condition in a family is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045098/" class="def">inherited</a>. Genetic counselors and other specially trained health professionals can help patients understand their <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000642019/" class="def">personal</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000642015/" class="def">family medical history</a>, their options for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046128/" class="def">genetic testing</a>, and the risks and benefits of learning <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046391/" class="def">genetic</a> information. If a patient chooses to get genetic testing, it may be done using a sample of blood, saliva, or skin. Genetic test results can reveal information about other family members and can create tension in the family. Genetic counselors can help people cope with their genetic testing results, including how to discuss the results with family members.</p></div><div id="CDR0000797087__92"><h3>Whether a person should get tested for hereditary kidney cancer depends on certain factors.</h3><p id="CDR0000797087__94">Certain clues in a person's medical history or family history may lead health professionals to think that an individual may have a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000754220/" class="def">hereditary syndrome</a>. With <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000444995/" class="def">kidney cancer</a>, individuals who have one or more of the following criteria may be referred for genetic counseling and testing:</p><ul id="CDR0000797087__95"><li class="half_rhythm"><div>family history of multiple relatives diagnosed with kidney cancer</div></li><li class="half_rhythm"><div>cancer developed at a young age</div></li><li class="half_rhythm"><div>multiple <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumors</a> in one <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046325/" class="def">kidney</a> or cancer in both kidneys</div></li><li class="half_rhythm"><div>diagnosis of a type of kidney cancer that is commonly inherited</div></li></ul></div></div><div id="CDR0000797087__27"><h2 id="_CDR0000797087__27_">What are the major hereditary kidney cancer syndromes?</h2><div id="CDR0000797087__27.kp" class="box"><h4><span class="title">Key Points for This Section</span></h4><ul><li class="half_rhythm"><div><a href="#CDR0000797087__32">Four hereditary kidney cancer syndromes and the genes that cause them have been identified.</a></div></li></ul></div><div id="CDR0000797087__32"><h3>Four hereditary kidney cancer syndromes and the genes that cause them have been identified.</h3></div><div id="CDR0000797087__40"><h3>Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC)</h3><p id="CDR0000797087__42">HLRCC was considered rare, but it may be one of the most common hereditary cancer syndromes. Some people who have HLRCC may not have symptoms. HLRCC is caused by harmful changes (also called mutations or pathogenic variants) in the <i><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794377/" class="def">FH</a></i> gene. People with HLRCC could have an increased risk of kidney cancer. The risk may be higher in males with <i>FH</i> mutations. Black people diagnosed with kidney cancer have more <i>FH</i> mutations than people from other <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000784947/" class="def">racial</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000784950/" class="def">ethnic groups</a>. HLRCC is associated with a unique type of kidney cancer that can be fast growing. People with HLRCC may also develop leiomyomas (<a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045614/" class="def">benign</a> smooth-muscle tumors) in the skin and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046645/" class="def">uterus</a> (fibroids) or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000390305/" class="def">paragangliomas</a> (benign tumors near <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046678/" class="def">adrenal glands</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045020/" class="def">blood vessels</a>, or <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000373935/" class="def">nerves</a>).</p><div id="CDR0000797087__43" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Areas%20of%20the%20body%20affected%20by%20hereditary%20leiomyomatosis%20and%20renal%20cell%20cancer%20(HLRCC)&p=BOOKS&id=604227_CDR0000793769.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK545658.5/bin/CDR0000793769.jpg" alt="Drawing showing areas of the body affected by hereditary leiomyomatosis and renal cell cancer, including the skin, kidneys, and uterus." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Areas of the body affected by hereditary leiomyomatosis and renal cell cancer (HLRCC). HLRCC is an inherited disorder that causes an increased risk of kidney cancer. It can also cause lesions in the skin and uterus (in females).</p></div></div><p id="CDR0000797087__44">The <i>FH</i> gene makes a protein called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794427/" class="def">fumarase</a>. Fumarase helps cells use <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000538149/" class="def">oxygen</a> and produce energy. When the <i>FH</i> gene is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044133/" class="def">mutated</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> are not able to use oxygen, which may lead to cancer. HLRCC is inherited in an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000793860/" class="def">autosomal dominant</a> manner. This means that if one parent has HLRCC, there is a 50% (1 in 2) chance their child will inherit the mutation in the <i>FH</i> gene.</p><p id="CDR0000797087__45">Learn more about HLRCC from the <a href="https://rarediseases.info.nih.gov/diseases/10096/hereditary-leiomyomatosis-and-renal-cell-cancer" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCATS Genetic and Rare Diseases Information Center</a>.</p></div><div id="CDR0000797087__34"><h3>Von Hippel-Lindau Disease (VHL)</h3><p id="CDR0000797087__36">VHL is a rare hereditary syndrome that is caused by harmful changes (also called mutations or pathogenic variants) in the <i><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794100/" class="def">VHL</a></i> gene. People with VHL have an increased risk of kidney cancer and renal <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046461/" class="def">cysts</a>. VHL is associated with a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000444982/" class="def">clear-cell</a> type kidney cancer, which is typically slow growing. People with VHL may also develop <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045772/" class="def">malignant</a> (cancer) and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045614/" class="def">benign</a> (noncancer) tumors in many parts of the body, including the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046481/" class="def">central nervous system</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000440115/" class="def">retina</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046254/" class="def">pancreas</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046678/" class="def">adrenal glands</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794890/" class="def">endolymphatic sac</a>, <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000615503/" class="def">epididymis</a> (in males), and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794110/" class="def">broad ligament</a> (in females).</p><div id="CDR0000797087__37" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Areas%20of%20the%20body%20affected%20by%20von%20Hippel-Lindau%20(VHL)%20disease&p=BOOKS&id=604227_CDR0000793775.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK545658.5/bin/CDR0000793775.jpg" alt="Drawing of a male figure and female figure showing areas of the body affected by von Hippel-Lindau disease. These areas include the central nervous system (including the brainstem, cerebellum, and spinal cord), retina, endolymphatic sac in the ear, adrenal glands, pancreas, kidneys, epididymis (in males), and broad ligament (in females)." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Areas of the body affected by von Hippel-Lindau (VHL) disease. VHL disease is an inherited disorder that causes tumors and cysts to grow in certain areas of the body, including the central nervous system (including the brainstem, cerebellum, and spinal cord), retina, endolymphatic sac in the ear, adrenal glands, pancreas, kidneys, epididymis (in males), and broad ligament (in females). VHL disease also causes an increased risk of certain types of cancer, especially kidney cancer and pancreatic cancer.</p></div></div><p id="CDR0000797087__38">The <i>VHL</i> gene is a type of gene called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046657/" class="def">tumor suppressor gene</a>. Normally, the <i>VHL</i> gene prevents <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> from growing and dividing too quickly. When the <i>VHL</i> gene is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044133/" class="def">mutated</a> in certain ways and loses its protective function, uncontrolled cell growth may lead to cancer. VHL is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045098/" class="def">inherited</a> in an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000793860/" class="def">autosomal dominant</a> manner. If one parent has VHL, there is a 50% (1 in 2) chance their child will inherit the harmful genetic change in the <i>VHL</i> gene.</p><p id="CDR0000797087__39">Learn more about VHL from the <a href="https://rarediseases.info.nih.gov/diseases/7855/von-hippel-lindau-disease" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">National Center for Advancing Translational Sciences (NCATS) Genetic and Rare Diseases Information Center</a>.</p></div><div id="CDR0000797087__46"><h3>Birt-Hogg-Dubé Syndrome (BHD)</h3><p id="CDR0000797087__48">BHD is a rare hereditary syndrome caused by harmful changes (also called mutations or pathogenic variants) in the <i><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794380/" class="def">FLCN</a></i> gene. People with BHD have an increased risk of multiple types of kidney cancer that are typically slow growing. People with BHD may also develop skin tumors called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000771540/" class="def">fibrofolliculomas</a>, lung <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046461/" class="def">cysts</a>, and spontaneous <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000793866/" class="def">pneumothorax</a> (collapsed lung).</p><div id="CDR0000797087__49" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Areas%20of%20the%20body%20affected%20by%20Birt-Hogg-Dube%20(BHD)%20syndrome&p=BOOKS&id=604227_CDR0000793770.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK545658.5/bin/CDR0000793770.jpg" alt="Drawing showing areas of the body affected by Birt-Hogg-Dube syndrome, including the skin, lungs, and kidneys." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Areas of the body affected by Birt-Hogg-Dube (BHD) syndrome. BHD syndrome is an inherited disorder that causes an increased risk of kidney cancer, benign (not cancer) skin lesions, collapsed lungs, and lung cysts.</p></div></div><p id="CDR0000797087__50">The <i>FLCN</i> gene is a <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046657/" class="def">tumor suppressor gene</a>. Normally, the <i>FLCN</i> gene prevents <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046476/" class="def">cells</a> from growing and dividing too quickly. When the <i>FLCN</i> gene is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044133/" class="def">mutated</a>, uncontrolled cell growth may lead to cancer. BHD is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045098/" class="def">inherited</a> in an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000793860/" class="def">autosomal dominant</a> manner. This means that if one parent has BHD, there is a 50% (1 in 2) chance their child will inherit the mutation in the <i>FLCN</i> gene.</p><p id="CDR0000797087__51">Learn more about BHD from the <a href="https://rarediseases.info.nih.gov/diseases/2322/birt-hogg-dube-syndrome" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCATS Genetic and Rare Diseases Information Center</a>.</p></div><div id="CDR0000797087__52"><h3>Hereditary Papillary Renal Cancer (HPRC)</h3><p id="CDR0000797087__54">HPRC is a rare hereditary syndrome caused by harmful changes (also called mutations or pathogenic variants) in the <i><a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794425/" class="def">MET</a></i> gene. People with HPRC have an increased risk of a type of kidney cancer called <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000794041/" class="def">papillary kidney cancer</a>, which is typically slow growing. Papillary kidney cancer forms in the cells lining the very small tubes in the kidney called renal tubules.</p><div id="CDR0000797087__55" class="figure bk_fig"><div class="graphic"><a href="/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Papillary%20renal%20cancer%20forms%20in%20cells%20that%20line%20the%20renal%20tubules%20in%20the%20kidney&p=BOOKS&id=604227_CDR0000793771.jpg" target="tileshopwindow" class="inline_block pmc_inline_block ts_canvas img_link" title="Click on image to zoom"><div class="ts_bar small" title="Click on image to zoom"></div><img src="/books/NBK545658.5/bin/CDR0000793771.jpg" alt="Papillary renal cancer; drawing showing the left kidney, renal pelvis, and ureter. Also shown is a pullout of the renal tubules, which is where urine is made." class="tileshop" title="Click on image to zoom" /></a></div><div class="caption"><p>Papillary renal cancer forms in cells that line the renal tubules in the kidney. The renal tubules remove waste from the blood and make urine. Urine moves through the renal tubules into the renal pelvis and ureter, which carries urine from the kidney to the bladder.</p></div></div><p id="CDR0000797087__56">The <i>MET</i> gene makes a protein called MET that is involved in <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000798994/" class="def">cell signaling</a> and growth. When the <i>MET</i> gene is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044133/" class="def">mutated</a>, cells may not respond to signals that normally prevent them from growing, causing cancer to develop. HPRC is <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045098/" class="def">inherited</a> in an <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000793860/" class="def">autosomal dominant</a> manner. This means that if one parent has HPRC, there is a 50% (1 in 2) chance their child will inherit the mutation in the <i>MET</i> gene.</p><p id="CDR0000797087__57">Learn more about papillary kidney cancer from the <a href="https://rarediseases.info.nih.gov/diseases/9572/papillary-renal-cell-carcinoma" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCATS Genetic and Rare Diseases Information Center</a>.</p></div></div><div id="CDR0000797087__58"><h2 id="_CDR0000797087__58_">What happens after a hereditary kidney cancer syndrome diagnosis?</h2><p id="CDR0000797087__59">Most recommendations for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046171/" class="def">screening</a> and treating people with kidney cancer are based on evidence obtained from <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a>. Because families with these hereditary kidney cancer syndromes are rare, many of these studies did not include these types of hereditary kidney cancer. When studies of families with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000754220/" class="def">hereditary syndromes</a> are not available, guidelines on how to <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000454803/" class="def">monitor</a> and care for patients with <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045098/" class="def">inherited</a> kidney cancer are based on the expert opinion and consensus of health care professionals who have experience in treating families with these syndromes.</p><p id="CDR0000797087__60">Families with these hereditary syndromes are watched closely for <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000750109/" class="def">signs</a> of disease in the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046325/" class="def">kidneys</a> and in other organs. Most kidney <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046634/" class="def">tumors</a> that occur can be removed by surgery, but they may <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046556/" class="def">recur</a> (come back). Other treatment options may be available.</p><p id="CDR0000797087__61">For more information about screening and treatment options for each hereditary syndrome, see <a href="/books/n/pdqcis/CDR0000574548/">Genetics of Renal Cell Carcinoma</a>. For more information about the treatment of kidney cancer in the general population, see <a href="/books/n/pdqcis/CDR0000276462/">Renal Cell Cancer Treatment</a>.</p></div><div id="CDR0000797087__62"><h2 id="_CDR0000797087__62_">Are clinical trials available for hereditary kidney cancer syndromes?</h2><p id="CDR0000797087__70">Use our <a href="https://www.cancer.gov/about-cancer/treatment/clinical-trials/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">clinical trial search</a> to find <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044267/" class="def">NCI</a>-supported cancer <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000045961/" class="def">clinical trials</a> that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. <a href="https://www.cancer.gov/research/participate/clinical-trials" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">General information</a> about clinical trials is also available.</p></div><div id="CDR0000797087__64"><h2 id="_CDR0000797087__64_">Learn more about kidney (renal cell) cancer</h2><p id="CDR0000797087__65">For more information from the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044266/" class="def">National Cancer Institute</a>
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and the <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000044268/" class="def">National Institutes of Health</a> about <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000444995/" class="def">kidney cancer</a> and <a href="/books/n/pdqcis/glossary/def-item/glossary_CDR0000046391/" class="def">genetics</a>, see the following:</p><ul id="CDR0000797087__66"><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/types/kidney" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Kidney Cancer Home Page</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/about-cancer/treatment/drugs/kidney" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Drugs Approved for Kidney Cancer</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/about-cancer/causes-prevention/genetics/genetic-testing-fact-sheet" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Genetic Testing for Inherited Cancer Susceptibility Syndromes</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://rarediseases.info.nih.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Genetic and Rare Diseases Information Center</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://medlineplus.gov/genetics/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">MedlinePlus: Genetics</a>
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</div></li><li class="half_rhythm"><div>
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<a href="/books/n/pdqcis/CDR0000276462/">Renal Cell Cancer Treatment</a>
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</div></li><li class="half_rhythm"><div>
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<a href="/books/n/pdqcis/CDR0000343585/">Transitional Cell Cancer of the Renal Pelvis and Ureter Treatment</a>
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</div></li><li class="half_rhythm"><div>
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<a href="/books/n/pdqcis/CDR0000415235/">Wilms Tumor and Other Childhood Kidney Tumors Treatment</a>
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</div></li></ul><p id="CDR0000797087__64_md_40">For general cancer information and other resources from the National Cancer Institute, visit:</p><ul id="CDR0000797087__64_md_41"><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/about-cancer" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">About Cancer</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/about-cancer/diagnosis-staging/staging" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Staging</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/publications/patient-education/chemo-and-you" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Chemotherapy and You: Support for People With Cancer</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/publications/patient-education/radiation-therapy-and-you" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Radiation Therapy and You: Support for People With Cancer</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/about-cancer/coping" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Coping with Cancer</a>
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</div></li><li class="half_rhythm"><div>
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<a href="https://www.cancer.gov/about-cancer/coping/questions" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Questions to Ask Your Doctor about Cancer</a>
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</div></li><li class="half_rhythm"><div><a href="https://cancercontrol.cancer.gov/ocs/resources/survivors.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">For Survivors and Caregivers</a>
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</div></li></ul></div><div id="CDR0000797087__AboutThis_1"><h2 id="_CDR0000797087__AboutThis_1_">About This PDQ Summary</h2><div id="CDR0000797087__AboutThis_2"><h3>About PDQ</h3><p id="CDR0000797087__AboutThis_3">Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in <a href="https://www.cancer.gov/espanol/publicaciones/pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Spanish</a>.</p><p id="CDR0000797087__AboutThis_4">PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.</p></div><div id="CDR0000797087__AboutThis_5"><h3>Purpose of This Summary</h3><p id="CDR0000797087__AboutThis_6">This PDQ cancer information summary has current information about the genetics of kidney cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.</p></div><div id="CDR0000797087__AboutThis_7"><h3>Reviewers and Updates</h3><p id="CDR0000797087__AboutThis_8">Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Updated") is the date of the most recent change.
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</p><p id="CDR0000797087__AboutThis_9">The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the <a href="https://www.cancer.gov/publications/pdq/editorial-boards/genetics" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PDQ Cancer Genetics Editorial Board</a>.
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</p></div><div id="CDR0000797087__AboutThis_10"><h3>Clinical Trial Information</h3><p id="CDR0000797087__AboutThis_11">A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
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</p><p id="CDR0000797087__AboutThis_12">Clinical trials can be found online at <a href="https://www.cancer.gov/research/participate/clinical-trials" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCI's website</a>. For more information, call the <a href="https://www.cancer.gov/contact/contact-center" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Cancer Information Service</a> (CIS), NCI's contact center, at 1-800-4-CANCER (1-800-422-6237).
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</p></div><div id="CDR0000797087__AboutThis_13"><h3>Permission to Use This Summary</h3><p id="CDR0000797087__AboutThis_14">PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”
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</p><p id="CDR0000797087__AboutThis_15">The best way to cite this PDQ summary is:</p><p id="CDR0000797087__AboutThis_21">PDQ® Cancer Genetics Editorial Board. PDQ Hereditary Kidney Cancer Syndromes. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: <a href="https://www.cancer.gov/types/kidney/patient/kidney-genetics-pdq" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">https://www.cancer.gov/types/kidney/patient/kidney-genetics-pdq</a>. Accessed <MM/DD/YYYY>. </p><p id="CDR0000797087__AboutThis_16">Images in this summary are used with permission of the author(s), artist, and/or publisher for use in the PDQ summaries only. If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. It cannot be given by the National Cancer Institute. Information about using the images in this summary, along with many other images related to cancer can be found in <a href="https://visualsonline.cancer.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Visuals Online</a>. Visuals Online is a collection of more than 3,000 scientific images.
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</p></div><div id="CDR0000797087__AboutThis_17"><h3>Disclaimer</h3><p id="CDR0000797087__AboutThis_18">The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the <a href="https://www.cancer.gov/about-cancer/managing-care" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Managing Cancer Care</a> page.</p></div><div id="CDR0000797087__AboutThis_19"><h3>Contact Us</h3><p id="CDR0000797087__AboutThis_20">More information about contacting us or receiving help with the Cancer.gov website can be found on our <a href="https://www.cancer.gov/contact" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Contact Us for Help</a> page. Questions can also be submitted to Cancer.gov through the website’s <a href="https://www.cancer.gov/contact/email-us" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">E-mail Us</a>.</p></div></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK545658.5/?report=reader">PubReader</a></li><li><a href="/books/NBK545658.5/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK545658" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK545658" style="display:none" title="Cite this Page"><div class="bk_tt">PDQ Cancer Genetics Editorial Board. Hereditary Kidney Cancer Syndromes (PDQ®): Patient Version. 2024 Jun 6. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. <span class="bk_cite_avail"></span></div></div></li><li><a href="#" class="toggle-glossary-link" title="Enable/disable links to the glossary">Disable Glossary Links</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Version History</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter shutter_closed" title="Show/hide content" remembercollapsed="true" pgsec_name="version_history" id="Shutter"></a></div><div class="portlet_content" style="display: none;"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><span class="bk_col_itm"><a href="/books/NBK545658.6/">NBK545658.6</a></span> December 2, 2024</li><li><span class="bk_col_itm">NBK545658.5</span> June 6, 2024 (Displayed Version)</li><li><span class="bk_col_itm"><a href="/books/NBK545658.4/">NBK545658.4</a></span> April 17, 2024</li><li><span class="bk_col_itm"><a href="/books/NBK545658.3/">NBK545658.3</a></span> September 5, 2023</li><li><span class="bk_col_itm"><a href="/books/NBK545658.2/">NBK545658.2</a></span> March 11, 2021</li><li><span class="bk_col_itm"><a href="/books/NBK545658.1/">NBK545658.1</a></span> August 23, 2019</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>In this Page</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="page-toc" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="#CDR0000797087__71" ref="log$=inpage&link_id=inpage">What is kidney cancer?</a></li><li><a href="#CDR0000797087__77" ref="log$=inpage&link_id=inpage">What is hereditary kidney cancer?</a></li><li><a href="#CDR0000797087__87" ref="log$=inpage&link_id=inpage">What is genetic counseling and who should receive it?</a></li><li><a href="#CDR0000797087__27" ref="log$=inpage&link_id=inpage">What are the major hereditary kidney cancer syndromes?</a></li><li><a href="#CDR0000797087__58" ref="log$=inpage&link_id=inpage">What happens after a hereditary kidney cancer syndrome diagnosis?</a></li><li><a href="#CDR0000797087__62" ref="log$=inpage&link_id=inpage">Are clinical trials available for hereditary kidney cancer syndromes?</a></li><li><a href="#CDR0000797087__64" ref="log$=inpage&link_id=inpage">Learn more about kidney (renal cell) cancer</a></li><li><a href="#CDR0000797087__AboutThis_1" ref="log$=inpage&link_id=inpage">About This PDQ Summary</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related publications</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK169222/">Health Professional Version</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/26389448" ref="ordinalpos=1&linkpos=1&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Renal Cell Cancer Treatment (PDQ®): Patient Version.</a><span class="source">[PDQ Cancer Information Summari...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Renal Cell Cancer Treatment (PDQ®): Patient Version.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">PDQ Adult Treatment Editorial Board. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">PDQ Cancer Information Summaries. 2002</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/26389239" ref="ordinalpos=1&linkpos=2&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Myelodysplastic Syndromes Treatment (PDQ®): Patient Version.</a><span class="source">[PDQ Cancer Information Summari...]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Myelodysplastic Syndromes Treatment (PDQ®): Patient Version.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">PDQ Adult Treatment Editorial Board. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">PDQ Cancer Information Summaries. 2002</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/26389225" ref="ordinalpos=1&linkpos=3&log$=relatedreviews&logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Adrenocortical 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