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<title>Anatomy, Head and Neck: Eye, Superior Tarsal Muscle (Müller Muscle) - StatPearls - NCBI Bookshelf</title>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK540964_"><span class="title" itemprop="name">Anatomy, Head and Neck: Eye, Superior Tarsal Muscle (Müller Muscle)</span></h1><p class="contrib-group"><h4>Authors</h4><span itemprop="author">Tushar Dave</span><sup>1</sup>; <span itemprop="author">Saama Sabeti</span><sup>2</sup>; <span itemprop="author">Bhupendra C. Patel</span><sup>3</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup> Precision Cornea Centre, Ottawa, Canada</div><div class="affiliation"><sup>2</sup> Precision Cornea Centre, Ottawa, Canada</div><div class="affiliation"><sup>3</sup> University of Utah</div><p class="small">Last Update: <span itemprop="dateModified">October 5, 2024</span>.</p></div><div class="body-content whole_rhythm" itemprop="text"><div id="article-38200.s1"><h2 id="_article-38200_s1_">Introduction</h2><p>The superior tarsal muscle, also known as the Müller muscle, is an accessory smooth muscle that allows for the retraction and elevation of the upper eyelid. This muscle receives sympathetic innervation from fibers originating from the sympathetic cervical ganglion, and vascular supply from the superior branches of the ophthalmic artery.</p><p>The superior tarsal muscle is often affected in thyroid eye disease-associated ophthalmopathy as the disease-mediated inflammation and fibrosis occurring within the muscle cause further upper lid retraction. Injury to the innervation of the superior tarsal muscle, as seen in Horner Syndrome, results in ptosis. </p><p>The superior tarsal muscle is routinely encountered in oculoplastic surgery, including ptosis-correcting procedures. Different approaches can be used to correct ptosis, but the Müller muscle-conjunctival resection involves removing a portion of the superior tarsal muscle to remedy the ptosis (see <b>Image</b>. Eye—Superior Tarsal Muscle).<a class="bk_pop" href="#article-38200.r1">[1]</a><a class="bk_pop" href="#article-38200.r2">[2]</a> Understanding the anatomy and function of the superior tarsal muscle is essential in managing conditions that affect upper eyelid movement.</p></div><div id="article-38200.s2"><h2 id="_article-38200_s2_">Structure and Function</h2><p>The superior tarsal muscle is composed of thin fibers of smooth muscle tissue and is approximately 15 mm wide and 10 mm long. The muscle originates from the inferior aspect of the levator palpebrae superioris and inserts onto the superior tarsal plate of the upper eyelid.<a class="bk_pop" href="#article-38200.r3">[3]</a> The superior tarsal plate is made of dense connective tissue and functions to support the upper eyelid and maintain its shape. </p><p>The superior tarsal muscle has the unique function of assisting the levator palpebrae superioris by maintaining upper eyelid elevation after being raised by the levator palpebrae superioris.<a class="bk_pop" href="#article-38200.r4">[4]</a> The superior tarsal muscle also lifts the upper eyelid to an additional 2 mm beyond the range of the levator palpebrae superioris, following a sympathetic nervous system response.<a class="bk_pop" href="#article-38200.r5">[5]</a> </p><p>The superior tarsal muscle has a much more significant role in levator action when compared to the levator palpebrae superioris than previously thought. Research has determined that the superior tarsal muscle transmits considerable power to the levator palpebrae superioris when elevating the eyelid, furthering the synergistic interaction between itself and the levator palpebrae superioris.<a class="bk_pop" href="#article-38200.r6">[6]</a></p></div><div id="article-38200.s3"><h2 id="_article-38200_s3_">Embryology</h2><p>The eyelid develops as a whole from a combination of secondary mesenchymal (mesoderm invaded by cranial neural crest cells) and surface ectodermal tissues. The superior tarsal muscle, along with the orbital septum, the tarsal plate, and the levator palpebrae superioris, develop from secondary mesenchymal tissues.</p><p>Eyelid formation is first seen at the 5-week mark, and the levator aponeurosis (point of origin of the superior tarsal muscle) is first seen at week 12. The superior tarsal muscle is then seen at week 14.<a class="bk_pop" href="#article-38200.r7">[7]</a></p></div><div id="article-38200.s4"><h2 id="_article-38200_s4_">Blood Supply and Lymphatics</h2><p>Although considerable variation exists in the arterial supply of the eyelid, the superior tarsal muscle is most commonly supplied by the superior (lateral) branch of the ophthalmic artery. This branch also provides blood flow to the levator muscle, superior rectus, superior oblique, and lateral rectus. The ophthalmic artery also has a medial muscular branch that supplies blood to the remaining extraocular muscles.<a class="bk_pop" href="#article-38200.r8">[8]</a></p><p>Venous drainage of the superior tarsal muscle occurs through the vortex veins, which originate from the posterior aspect of the eye. Blood from the vortex veins then flows into the superior and inferior orbital veins before reaching the cavernous sinus.</p></div><div id="article-38200.s5"><h2 id="_article-38200_s5_">Nerves</h2><p>The sympathetic nervous system innervates the superior tarsal muscle. More specifically, the muscle is innervated by postganglionic sympathetic fibers that have synapses in the superior sympathetic cervical ganglia. These fibers wrap around the internal carotid artery, forming the internal carotid plexus, and enter the skull. From here, the plexus fibers reach the orbit via the ophthalmic artery and subsequently innervate the superior tarsal muscle <a class="bk_pop" href="#article-38200.r9">[9]</a>.</p></div><div id="article-38200.s6"><h2 id="_article-38200_s6_">Muscles</h2><p>The superior tarsal muscle is made of smooth muscle but displays several characteristics that differentiate it from the smooth muscle found elsewhere in the body. Histological analyses of the muscle reveal an area of gradual transition between the striated skeletal muscle of the levator palpebrae superioris and the smooth muscle of the superior tarsal muscles. Thus, smooth muscle fibers mix with striated muscle fibers beyond this transition zone. Fibers of both muscles are also interspersed with connective tissue.<a class="bk_pop" href="#article-38200.r10">[10]</a></p></div><div id="article-38200.s7"><h2 id="_article-38200_s7_">Physiologic Variants</h2><p>The superior tarsal muscle has specific physiologic variants that differ based on their attachment to the superior tarsal plate. Four variations exist, as listed below.</p><ul><li class="half_rhythm"><div>Pattern 1: The superior tarsal muscle attaches to the upper border of the superior tarsal plate.</div></li><li class="half_rhythm"><div>Pattern 2M (medial): The superior tarsal muscle attaches to the medial aspect of the plate.</div></li><li class="half_rhythm"><div>Pattern 2L (lateral): The superior tarsal muscle attaches to the lateral aspect of the plate.</div></li><li class="half_rhythm"><div>Pattern 3: The superior tarsal muscle attaches along the whole extent of the superior tarsal plate.</div></li></ul><p>Pattern 3 is the most frequently observed variant.<a class="bk_pop" href="#article-38200.r10">[10]</a></p></div><div id="article-38200.s8"><h2 id="_article-38200_s8_">Surgical Considerations</h2><p>Specific surgeries that encounter the superior tarsal muscle include procedures that correct elevation dysfunctions of the upper eyelid. Müller muscle-conjunctival resection is a surgical procedure used to treat blepharoptosis. The surgery is performed using a conjunctival approach where the conjunctiva, the Müller muscle, and sometimes, a portion of the tarsal plate are resected. </p><p>Levator advancement or resection is another surgical procedure used to treat blepharoptosis. Here, the surgery is completed through an external eyelid crease incision, and a portion of the levator palpebrae superioris is imbricated or advanced. Given its proximity to the superior tarsal muscle, care is taken not to damage the superior tarsal muscle, which can result in overcorrection of the blepharoptosis.</p><p>The type of surgery chosen relies on a multitude of factors, including the etiology of the ptosis, the current function of the levator muscle, and the response to sympathomimetic eye drops. </p><p>A recent meta-analysis comparing the outcomes of Müller muscle conjunctival resection with those of external levator advancement in patients undergoing ptosis surgery demonstrated that both procedures were efficacious in treating ptosis. While this study found no statistical difference between the 2 procedures regarding the postoperative marginal reflex distance (the distance from the upper lid margin to the corneal light reflex), it did reveal that rates of overcorrection and reoperations were higher in the levator advancement group.<a class="bk_pop" href="#article-38200.r11">[11]</a> However, the most important factors for determining the type of surgery required include the degree and type of ptosis, the amount of levator function, and the surgeon's experience or comfort with the procedure.<a class="bk_pop" href="#article-38200.r12">[12]</a></p></div><div id="article-38200.s9"><h2 id="_article-38200_s9_">Clinical Significance</h2><p>The superior tarsal muscle plays an accessory but pertinent role in lid elevation and retraction. The clinical significance of this muscle is greatly elevated in conditions such as thyroid eye disease and Horner syndrome.</p><p>In thyroid eye disease, including Graves orbitopathy, lymphocytes infiltrate the extraocular muscles and superior tarsal muscle, causing enlargement of these structures. While chronic infiltration and inflammation in the extraocular muscles lead to proptosis and restrictions in extraocular movements, the same process in the superior tarsal muscle can lead to lid retraction.</p><p>In Horner syndrome, a constellation of upper eyelid ptosis, miosis, and anhidrosis occurs due to lesions along the sympathetic pathway. Ptosis arises from superior tarsal muscle paralysis.<a class="bk_pop" href="#article-38200.r13">[13]</a></p></div><div id="article-38200.s10"><h2 id="_article-38200_s10_">Review Questions</h2><ul><li class="half_rhythm"><div>
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</div></li></ul></div><div class="floats-group" id="article-38200.s11"></div><div id="article-38200.s12"><h2 id="_article-38200_s12_">References</h2><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="article-38200.r1">Koka K, Patel BC. <span class="ref-journal">StatPearls [Internet].</span> StatPearls Publishing; Treasure Island (FL): Jul 10, 2023. Ptosis Correction. [<a href="https://pubmed.ncbi.nlm.nih.gov/30969650" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30969650</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="article-38200.r2">Osaki TH, Monteiro LG, Osaki MH. Management of eyelid retraction related to thyroid eye disease. <span><span class="ref-journal">Taiwan J Ophthalmol. </span>2022 Jan-Mar;<span class="ref-vol">12</span>(1):12-21.</span> [<a href="/pmc/articles/PMC8988987/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8988987</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/35399960" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35399960</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="article-38200.r3">Kakizaki H, Madge SN, Selva D. Insertion of the levator aponeurosis and Müller's muscle on the tarsus: a cadaveric study in Caucasians. <span><span class="ref-journal">Clin Exp Ophthalmol. </span>2010 Aug;<span class="ref-vol">38</span>(6):635-7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/20584021" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20584021</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="article-38200.r4">Putterman AM, Fett DR. Müller's muscle in the treatment of upper eyelid ptosis: a ten-year study. <span><span class="ref-journal">Ophthalmic Surg. </span>1986 Jun;<span class="ref-vol">17</span>(6):354-60.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/3737107" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3737107</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="article-38200.r5">Beard C. 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BRANCHES. <span><span class="ref-journal">Br J Ophthalmol. </span>1962 Apr;<span class="ref-vol">46</span>(4):212-47.</span> [<a href="/pmc/articles/PMC510187/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC510187</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/18170772" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18170772</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="article-38200.r9">Pan E, Nie YF, Wang ZJ, Peng LX, Wu YH, Li Q. 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The human superior tarsal muscle (Müller's muscle): a morphological classification with surgical correlations. <span><span class="ref-journal">Anat Sci Int. </span>2010 Mar;<span class="ref-vol">85</span>(1):1-7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/19373523" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19373523</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="article-38200.r11">Karam M, Alsaif A, Abul A, Alkhabbaz A, Alotaibi A, Shareef E, Behbehani R. Muller's muscle conjunctival resection versus external levator advancement for ptosis repair: systematic review and meta-analysis. <span><span class="ref-journal">Int Ophthalmol. </span>2023 Jul;<span class="ref-vol">43</span>(7):2563-2573.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/36692699" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 36692699</span></a>]</div></dd><dt>12.</dt><dd><div class="bk_ref" id="article-38200.r12">Aakalu VK, Setabutr P. Current ptosis management: a national survey of ASOPRS members. <span><span class="ref-journal">Ophthalmic Plast Reconstr Surg. </span>2011 Jul-Aug;<span class="ref-vol">27</span>(4):270-6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21346664" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21346664</span></a>]</div></dd><dt>13.</dt><dd><div class="bk_ref" id="article-38200.r13">Martin TJ. Horner Syndrome: A Clinical Review. <span><span class="ref-journal">ACS Chem Neurosci. </span>2018 Feb 21;<span class="ref-vol">9</span>(2):177-186.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/29260849" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 29260849</span></a>]</div></dd></dl></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin">
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<b>Disclosure: </b>Tushar Dave declares no relevant financial relationships with ineligible companies.</p></div></dd><dt></dt><dd><div><p class="no_top_margin">
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<b>Disclosure: </b>Saama Sabeti declares no relevant financial relationships with ineligible companies.</p></div></dd><dt></dt><dd><div><p class="no_top_margin">
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<b>Disclosure: </b>Bhupendra Patel declares no relevant financial relationships with ineligible companies.</p></div></dd></dl></div><div class="bk_prnt_sctn"><h2>Figures</h2><div class="whole_rhythm bk_prnt_obj bk_first_prnt_obj"><div id="article-38200.image.f1" class="figure bk_fig"><div class="graphic"><img src="/books/NBK540964/bin/Eye__Superior__Tarsal__Muscle-01.jpg" alt="Eye—Superior Tarsal Muscle" /></div><div class="caption"><p>Eye—Superior Tarsal Muscle. The illustration shows the tarsal gland, levator palpebrae superioris muscle, sebaceous gland of an eyelash, tarsus, conjunctiva, superior conjunctival fornix, tendon of levator palpebrae superioris muscle, orbital septum, superior tarsal muscle (smooth muscle), orbicularis oculi muscle, and periosteum. StatPearls Publishing Illustration</p></div></div></div></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © 2025, StatPearls Publishing LLC.<p class="small">
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</a>), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not required to obtain permission to distribute this article, provided that you credit the author and journal.
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</p></div><div class="small"><span class="label">Bookshelf ID: NBK540964</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31082008" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">31082008</a></span></div></div></div>
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